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フルテキストURL fulltext.pdf
著者 Yokoyama, Sho| Honda, Hiroyuki| Otsuka, Yuki| Tokumasu, Kazuki| Nakano, Yasuhiro| Sakurada, Yasue| Matsuda, Yui| Sunada, Naruhiko| Hasegawa, Toru| Takase, Ryosuke| Omura, Daisuke| Soejima, Yoshiaki| Ueda, Keigo| Kishida, Masayuki| Otsuka, Fumio|
キーワード blood glucose diabetes mellitus long COVID omicron variant post-COVID-19 condition
発行日 2024-07-13
出版物タイトル Journal of Clinical Medicine
13巻
14号
出版者 MDPI
開始ページ 4099
ISSN 2077-0383
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2024 by the authors.
論文のバージョン publisher
PubMed ID 39064139
DOI 10.3390/jcm13144099
Web of Science KeyUT 001278836700001
関連URL isVersionOf https://doi.org/10.3390/jcm13144099
フルテキストURL fulltext.pdf
著者 Nagao, Shoji| Nishio, Shin| Takehara, Kazuhiro| Sato, Shinya| Satoh, Toyomi| Shimada, Muneaki| Yamaguchi, Satoshi| Tanabe, Hiroshi| Takano, Masashi| Horie, Kouji| Takei, Yuji| Imai, Yuichi| Hibino, Yumi| Hasegawa, Kosei| Takekuma, Munetaka| Nakamura, Kazuto| Takano, Hirokuni| Fujiwara, Keiichi| Masuyama, Hisashi|
キーワード Recurrent endometrial cancer Re-administration of platinum-based chemotherapy Platinum-free interval Secondary platinum response
備考 The version of record of this article, first published in International Journal of Clinical Oncology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10147-024-02585-1|
発行日 2024-07-13
出版物タイトル International Journal of Clinical Oncology
29巻
10号
出版者 Springer Science and Business Media LLC
開始ページ 1594
終了ページ 1601
ISSN 1341-9625
NCID AA11086579
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2024
論文のバージョン publisher
PubMed ID 39001945
DOI 10.1007/s10147-024-02585-1
Web of Science KeyUT 001272243200001
関連URL isVersionOf https://doi.org/10.1007/s10147-024-02585-1
フルテキストURL fulltext20240723-01.pdf
著者 Fukui, Yusuke| Tadokoro, Koh| Hamada, Minaki| Asada, Kyoichi| Lee, Lyang-Ja| Tachiki, Hidehisa| Morihara, Ryuta| Abe, Koji| Yamashita, Toru|
キーワード Alzheimer’s disease biochemical marker dementia risk test liquid chromatography-MS/MS mild cognitive impairment peptidome selected reaction monitoring
備考 This is an Accepted Manuscript of an article published by IOS Press.|
発行日 2024-06-25
出版物タイトル Journal of Alzheimer's Disease
100巻
1号
出版者 IOS Press
開始ページ 219
終了ページ 228
ISSN 1387-2877
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 38848173
DOI 10.3233/jad-230915
Web of Science KeyUT 001265662600015
関連URL isVersionOf https://doi.org/10.3233/jad-230915
JaLCDOI 10.18926/AMO/67199
フルテキストURL 78_3_245.pdf
著者 Akagawa, Manabu| Saito, Hidetomo| Takahashi, Yasuhiro| Iwamoto, Yosuke| Iida, Junpei| Yoshikawa, Takayuki| Abe, Toshiki| Saito, Kimio| Kijima, Hiroaki| Kasukawa, Yuji| Hongo, Michio| Miyakoshi, Naohisa|
抄録 Although several studies have suggested a possible association between sarcopenia and knee osteoarthritis (OA) in the elderly, there remains no definitive evidence. Recently, however, the serum creatinine/cystatin C ratio (sarcopenia index: SI) was reported to correlate with skeletal muscle mass. The present retrospective study therefore investigated the impact of reduced skeletal muscle mass on advanced knee OA using SI. In 55 individuals scheduled for knee osteotomy or knee arthroplasty, correlations between SI and patient-reported outcomes such as the Knee Society Score (KSS), Knee Injury and Osteoarthritis Outcome Score (KOOS), and Oxford Knee Score (OKS) were explored. Significant associations were found between SI and the KSS functional activity score (β=0.37; p=0.022), KOOS subscale for activities of daily living (β=0.42; p=0.0096), and OKS (β=0.42; p=0.0095). This study underscores the role of reduced muscle mass in functional outcomes and introduces SI as a valuable marker for assessing muscle loss in knee OA patients.
キーワード knee osteoarthritis sarcopenia index reduced muscle mass activities of daily living functional activity
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-06
78巻
3号
出版者 Okayama University Medical School
開始ページ 245
終了ページ 250
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38902212
Web of Science KeyUT 001267351000005
フルテキストURL fulltext20240531-01.pdf
著者 Tanaka, Takaaki| Taoka, Masataka| Makimoto, Go| Ninomiya, Kiichiro| Higo, Hisao| Fujii, Masanori| Ichihara, Eiki| Ohashi, Kadoaki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu|
キーワード immune checkpoint inhibitor nivolumab ipilimumab cytokine release syndrome immune effector cell-associated neurotoxicity syndrome
発行日 2024-05-01
出版物タイトル Internal Medicine
63巻
9号
出版者 Japanese Society of Internal Medicine
開始ページ 1261
終了ページ 1267
ISSN 0918-2918
NCID AA10827774
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2024 by The Japanese Society of Internal Medicine
論文のバージョン publisher
PubMed ID 37722894
DOI 10.2169/internalmedicine.2429-23
Web of Science KeyUT 001223220900001
関連URL isVersionOf https://doi.org/10.2169/internalmedicine.2429-23
フルテキストURL K0007083_abstract_review.pdf K0007083_summary.pdf
著者 長宗 武司|
発行日 2024-03-25
資料タイプ 学位論文
学位授与番号 甲第7083号
学位授与年月日 2024-03-25
学位・専攻分野 博士(経済学)
授与大学 岡山大学
言語 日本語
フルテキストURL fulltext.pdf
著者 Kobayashi, Keiko| Atarashi, Hironori| Yamazaki, Shinichi| Kimura, Kunio|
備考 The version of record of this article, first published in Polymer Journal, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41428-023-00833-1|
発行日 2023-08-18
出版物タイトル Polymer Journal
55巻
12号
出版者 Springer Science and Business Media LLC
開始ページ 1393
終了ページ 1398
ISSN 0032-3896
NCID AA00777013
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2023.
論文のバージョン publisher
DOI 10.1038/s41428-023-00833-1
Web of Science KeyUT 001050641100001
関連URL isVersionOf https://doi.org/10.1038/s41428-023-00833-1
JaLCDOI 10.18926/AMO/66912
フルテキストURL 78_2_095.pdf
著者 Itano, Junko| Kiura, Katsuyuki| Maeda, Yoshinobu| Miyahara, Nobuaki|
抄録 The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases.
キーワード neuropeptide y Y1 receptor airway immune response bronchial epithelial cells respiratory disease
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2024-04
78巻
2号
出版者 Okayama University Medical School
開始ページ 95
終了ページ 106
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38688827
Web of Science KeyUT 001229151800001
JaLCDOI 10.18926/CTED/66771
タイトル(別表記) Implementation and Evaluation of Teacher Training on Food Allergy Education in Kindergarten ― Aiming to Foster Children Leading Healthy Lives, Regardless of the Presence of Food Allergies ―
フルテキストURL cted_014_047.pdf
著者 新宅 由実子| 井山 房子| 黒住 知代| 阿部 耕平| 小谷 香代| 鷹取 万友美| 岡田 恵太| 田中 真帆| 三木 彩織|
抄録  本研究の目的は,幼稚園において食物アレルギーと共に生活する子供を育む方策を検討することである。本研究では,食物アレルギー教育に関する教員研修を行い,研修中の教員の反応と研修前後のアンケート調査の結果を基に,その効果を評価した。
 研修後には,食物アレルギーやその対応によって生じる子供達の心境へも目を向ける必要性の理解が深まった。また事例検討を通して,幼稚園においても幼児なりに食物アレルギーを理解して対応できるように伝える必要性があると明らかになり,実際に指導できそうな具体的な場面も挙げられた。さらに研修中,脈々と受け継がれてきた“教育観”と,現在の多様化した時代背景や子供達の実態,社会的なつながりを踏まえて更新される“教育観”の中で揺れ動く教員の姿が見られ,その揺らぎや葛藤自体が,個別のニーズを適切に受け入れ,多様性を尊重する教師の観念を磨くことにつながっていると考えられた。
キーワード 食物アレルギー教育 (Food Allergy Education) 食物アレルギー研修 (Food Allergy Training) 幼稚園 (Kindergarten) 教員研修 (Teacher Training) 多様性 (Diversity)
出版物タイトル 岡山大学教師教育開発センター紀要
発行日 2024-03-29
14巻
開始ページ 47
終了ページ 55
ISSN 2186-1323
言語 日本語
著作権者 Copyright © 2024 岡山大学教師教育開発センター
論文のバージョン publisher
フルテキストURL oer_055_3_contents_e.pdf
出版物タイトル 岡山大学経済学会雑誌
発行日 2024-03-21
55巻
3号
ISSN 2433-4146
言語 日本語
著作権者 Copyright © 2024 岡山大学経済学会
論文のバージョン publisher
JaLCDOI 10.18926/OER/66736
タイトル(別表記) Die Grundlagen der wirtschaftlichen Entwicklung des Königreichs Sachsen(4)
フルテキストURL oer_055_3_041_061.pdf
著者 松尾 展成|
出版物タイトル 岡山大学経済学会雑誌
発行日 2024-03-21
55巻
3号
開始ページ 41
終了ページ 61
ISSN 2433-4146
言語 日本語
著作権者 Copyright © 2024 岡山大学経済学会
論文のバージョン publisher
JaLCDOI 10.18926/OER/66735
タイトル(別表記) Considering the Tax Equity Principle: The ‘Road Reflector’ Case Revisited
フルテキストURL oer_055_3_033_040.pdf
著者 普家 弘行|
出版物タイトル 岡山大学経済学会雑誌
発行日 2024-03-21
55巻
3号
開始ページ 33
終了ページ 40
ISSN 2433-4146
言語 日本語
著作権者 Copyright © 2024 岡山大学経済学会
論文のバージョン publisher
JaLCDOI 10.18926/OER/66734
フルテキストURL oer_055_3_025_031.pdf
著者 Niimura, Satoshi|
抄録 Adam Smith has advocated laissez-faire: however, many of Smith’s interpreters have pointed out that Smith discusses several exceptions to laissez-faire. Most of the important exceptions are not in Lectures on Jurisprudence (LJ); rather, they first appear in The Wealth of Nations (WN). These references seem to reflect a conscious shift in Smith’s policy principle from laissez-faire with small government to state intervention under big government. To compare small government with big, i.e. laissez-faire with government intervention, we must historically distinguish between two types of government intervention. The older type predated laissez-faire and included feudal governments, absolute governments and mercantilism, whereas the newer type includes various primitive forms of modern social or welfare states.
 Smith’s primary purpose in LJ is to criticise the older type of big government. In WN, he criticises the older big government in Books I, III and IV and promotes a newer type of government intervention in Books II and V, particularly regarding three important fields. First, he proposes regulating banking and financial markets in Book II of WN. Second, in contrast to LJ, where he gave little attention to public works and institutions, he considers them among the government’s three major duties in Book V of WN. Third, Smith drastically changes his views on taxation. He argues that they should be as light as possible in LJ, but in Book V of WN, he insists on increasing land taxes and abolishing taxes on necessaries; he also recommends introducing progressive taxes and abolishing regressive ones to achieve income redistribution.
 This paper considers the shifts in Smith’s position from endorsing the laissez-faire role of government in LJ to promoting government intervention in WN, particularly regarding financial regulation, public works and institutions and taxation.
出版物タイトル 岡山大学経済学会雑誌
発行日 2024-03-21
55巻
3号
開始ページ 25
終了ページ 31
ISSN 2433-4146
言語 英語
著作権者 Copyright © 2024 岡山大学経済学会
論文のバージョン publisher
JaLCDOI 10.18926/OER/66733
タイトル(別表記) Analysis of Regional Multiplier of Knowledge Intensive Industries and Creative Jobs based on Economic Base Model: Benefit of Municipal Collaboration
フルテキストURL oer_055_3_001_024.pdf
著者 中村 良平|
抄録  The traditional economic base model in the field of regional science contributes to identifying regional income producing industries and labor absorption. The economic base model has some conditional assumptions while it is quite tractable.
 Recently, papers by Moretti and others show significant regional multiplier effects of innovative jobs. They refocused on the traditional economic base model. However, their approach has several deficiencies concerning the identification of basic/non-basic industries and ambiguity of multiplier generating mechanisms.
 This paper focuses on regional specialization of knowledge intensive industries and creative jobs which are the driving forces of regional development in the framework of the economic base model. The estimations of regional economic multiplier in terms of employment are carried out using two-digit employment and three-digit job classification data at local municipality level with two-period data. Using these data, I explain regional differences by degree of specialization of knowledge intensive industries and creative workers. By doing this, I propose contemporary regional economic policy. Furthermore, by comparing multiplier effects at local municipality level and regional employment area level, benefits of municipal consolidation are shown.
出版物タイトル 岡山大学経済学会雑誌
発行日 2024-03-21
55巻
3号
開始ページ 1
終了ページ 24
ISSN 2433-4146
言語 日本語
著作権者 Copyright © 2024 岡山大学経済学会
論文のバージョン publisher
フルテキストURL oer_055_3_contents.pdf
出版物タイトル 岡山大学経済学会雑誌
発行日 2024-03-21
55巻
3号
ISSN 2433-4146
言語 日本語
著作権者 Copyright © 2024 岡山大学経済学会
論文のバージョン publisher
JaLCDOI 10.18926/AMO/66670
フルテキストURL 78_1_047.pdf
著者 Shimomura, Manabu| Shinozaki, Katsunori| Yano, Takuya| Akabane, Shintaro| Ohdan, Hideki| Hiroshima Surgical study group of Clinical Oncology (HiSCO)|
抄録 Oral fluoropyrimidines (FUs) have certain advantages over intravenous FUs, such as longer intervals between outpatient visits, no requirement for central venous port (CVP) implantation, and lower incidence of neutropenia. We previously reported the efficacy of S-1/oxaliplatin (SOX) with bevacizumab therapy as a first-line treatment for advanced colorectal cancer (CRC) in a prospective phase-II multi-institutional clinical trial (HiSCO-02 study). However, our prognostic data at the time lacked a sufficient observation period. Herein, we analyze the longer-term follow-up data, focusing on the status of eventual CVP implantation via an open-label, non-randomized, multicenter study. This study enrolled 55 patients (mean age, 64 years), of whom 43 died (41 of primary cancer). The median overall survival was 22.7 months (95% CI: 20.1-34.7 months). Post-treatment regimens after failure of first-line treatment were initiated in 43 patients; CPT11-based regimens were selected in most cases, and other oral FU combinations in nine. CVP was implanted in 35 patients prior to first-line treatment; eleven of the remaining 20 patients did not require CVP implantation. In conclusion, we report here the final prognostic update of the Phase II clinical trial examining the efficacy of SOX plus bevacizumab therapy, the results of which confirm the clinical efficacy of this regimen.
キーワード metastatic colorectal cancer chemotherapy S-1 prospective phase II study
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-02
78巻
1号
出版者 Okayama University Medical School
開始ページ 47
終了ページ 52
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38419314
Web of Science KeyUT 001203658200005
JaLCDOI 10.18926/AMO/66664
フルテキストURL 78_1_001.pdf
著者 Sun, Cuiming| Matsukawa, Akihiro|
抄録 Liver fibrosis, which ultimately leads to liver cirrhosis and hepatocellular carcinoma, is a major health burden worldwide. The progression of liver fibrosis is the result of the wound-healing response of liver to repeated injury. Hepatic macrophages are cells with high heterogeneity and plasticity and include tissue-resident macrophages termed Kupffer cells, and recruited macrophages derived from circulating monocytes, spleen and peritoneal cavity. Studies have shown that hepatic macrophages play roles in the initiation and progression of liver fibrosis by releasing inflammatory cytokines/chemokines and pro-fibrogenic factors. Furthermore, the development of liver fibrosis has been shown to be reversible. Hepatic macrophages have been shown to alternately regulate both the regression and turnover of liver fibrosis by changing their phenotypes during the dynamic progression of liver fibrosis. In this review, we summarize the role of hepatic macrophages in the progression and regression of liver fibrosis.
キーワード ERK-MAPK SPRED2 fibrosis macrophages
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2024-02
78巻
1号
出版者 Okayama University Medical School
開始ページ 1
終了ページ 8
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38419308
Web of Science KeyUT 001203658200006
フルテキストURL fulltext20240221-01.pdf
著者 Iijima, Yuta| Miki, Ryohei| Fujimura, Masatake| Oyadomari, Seiichi| Uehara, Takashi|
キーワード Methylmercury Neuronal cell death Apoptosis CHOP Knockout mouse
発行日 2024
出版物タイトル The Journal of Toxicological Sciences
49巻
2号
出版者 Japanese Society of Toxicology
開始ページ 55
終了ページ 60
ISSN 0388-1350
NCID AN00002808
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2024 The Japanese Society of Toxicology
論文のバージョン publisher
PubMed ID 38296529
DOI 10.2131/jts.49.55
Web of Science KeyUT 001157348600004
関連URL isVersionOf https://doi.org/10.2131/jts.49.55
フルテキストURL fulltext.pdf
著者 Nishimura, Ayumu| Miyoshi, Tomoko| Otsuka, Fumio| Matsukawa, Akihiro|
キーワード COVID-19 pandemic Medical students Career path Training hospitals
備考 The version of record of this article, first published in [Journal name], is available online at Publisher’s website: http://dx.doi.org/10.1186/s12909-023-05021-6|
発行日 2024-01-10
出版物タイトル BMC Medical Education
24巻
1号
出版者 BMC
開始ページ 55
ISSN 1472-6920
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2024.
論文のバージョン publisher
PubMed ID 38200534
DOI 10.1186/s12909-023-05021-6
Web of Science KeyUT 001140938300007
関連URL isVersionOf https://doi.org/10.1186/s12909-023-05021-6
タイトル(別表記) Application of grafting-induced flowering to the breeding and seed production of cruciferous crops
フルテキストURL srfa_113_055_059.pdf
著者 元木 航|
抄録 Grafting-induced flowering has the potential to be applied to plant breeding and seed production, to shorten the time needed for floral induction, and to expand the environment in which seed production is possible. However, it is difficult to induce flowering by grafting in some crop species, which currently limits the use of this technique to specific plant species. We have established a technique for inducing flowering in cabbage (Brassica oleracea L.) by grafting, which had hitherto been considered difficult, by clarifying the causes of different flowering responses caused by various rootstocks. This article introduces the key factors for the floral induction of cabbage by grafting and its potential application to the breeding and seed production of cruciferous crops. It was observed that cabbage grafted onto B. oleracea rootstocks did not flower at all, while cabbage grafted onto some accessions of Raphanus sativus rootstocks did flower. Furthermore, the ability of R. sativus to induce flowering of grafted cabbage varied even within the species. Immunoblotting analysis of the FLOWERING LOCUS T (FT) protein, a main component of florigen, revealed that floral induction was quantitatively correlated with the level of accumulated FT protein in the grafted scion. It was concluded that increasing the total amount of FT protein produced in the rootstock is important for the stable floral induction of the grafted cabbage, and this can be accomplished by increasing FT transcription and the leaf area of the rootstock. Field cultivation experiments with cabbage progenies obtained by the grafting method indicated the direct applicability of this method to breeding and seed production in cruciferous crops.
キーワード Brassica oleracea Raphanus sativus grafting rapid flowering induction florigen
出版物タイトル 岡山大学農学部学術報告
発行日 2024-02-01
113巻
開始ページ 55
終了ページ 59
ISSN 2186-7755
言語 日本語
論文のバージョン publisher