検索結果 1420 件
| JaLCDOI | 10.18926/AMO/69847 |
|---|---|
| フルテキストURL | 79_6_445.pdf |
| 著者 | Matsumi, Junya| |
| 抄録 | Our hospital began a PERIO program (perioperative patient management by a multi-disciplinary team from multiple departments) in 2016 to improve patient outcomes. We retrospectively analyzed the clinical effects of the PERIO program regarding the postoperative hospital stay (PHS) in the patients aged ≥ 18 years who underwent long lower-abdominal surgery at our hospital during the period April 2019 to March 2023. We excluded the cases of patients whose general anesthesia use was < 8 h, those for whom another surgery was performed simultaneously at another site, and emergency surgeries. The outcome was prolonged PHS, defined as exceeding the scheduled number of days specified in the patient’s clinical pathway. Among the 480 patients, prolonged PHS was observed for 270 patients (56.3%). In a multivariate logistic regression using advanced age, sex, high-risk general state, surgery requiring colon resection, serious adverse events (SAEs), and PERIO use, the following were associated with prolonged PHS: advance age (odds ratio [OR] 4.91, 95% confidence interval [CI]: 2.68-8.99, p=0.01), surgery requiring colon resection (OR 4.91, 95%CI: 2.68-8.99, p<0.001), SAE (OR 18.7, 95%CI: 7.22-48.2, p<0.001), and PERIO (OR 0.25, 95%CI: 0.13-0.47, p<0.001). The use of the PERIO program was thus beneficially associated with PHS after long lower-abdominal surgery. |
| キーワード | hospital stay ERAS surgery cancer perioperative management |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-12 |
| 巻 | 79巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 445 |
| 終了ページ | 449 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 41443806 |
| Web of Science KeyUT | 001674277500006 |
| JaLCDOI | 10.18926/AMO/69844 |
|---|---|
| フルテキストURL | 79_6_421.pdf |
| 著者 | Tanaka, Ayumi| Naoe, Shota| Takenaka, Reiju| Kanzaki, Norie| Sakoda, Akihiro| Yamaoka, Kiyonori| Kataoka, Takahiro| |
| 抄録 | Radon (222Rn; Rn) and thoron (220Rn; Tn) inhalation have been reported to enhance antioxidant activity in various organs. However, the effects of Tn on the colon have not been investigated. This study aimed to clarify the effects of Tn inhalation, alone and in combination with cyclosporin A (CsA), on dextran sulfate sodium (DSS)-induced colitis, and the accompanying oxidative stress, in mice. Male BALB/c mice were subjected to continuous 8-day Tn inhalation (c-Tn, 533±128 Bq/m3) or alternate-day Tn inhalation over the same period (f-Tn, 577±63Bq/m3), followed by treatment with 3% DSS and either CsA or vehicle for 7 days. Although the disease activity index (DAI) decreased significantly by day 2 in the c-Tn group, scores remained significantly higher than those in the f-Tn group. In the c-Tn group, superoxide dismutase and catalase activity in the colon were significantly elevated compared with those in sham controls. Thus, DSS-induced damage was effectively inhibited in the earlier stages by the c-Tn mode of inhalation than by the f-Tn mode. These findings suggest that continuous Tn inhalation more effectively attenuated early colitis symptoms than alternate-day inhalation, potentially through upregulation of antioxidant defenses. Tn and CsA showed no combined effects. |
| キーワード | thoron DSS antioxidant activity CsA colon |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-12 |
| 巻 | 79巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 421 |
| 終了ページ | 429 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 41443803 |
| Web of Science KeyUT | 001674277500003 |
| JaLCDOI | 10.18926/AMO/69843 |
|---|---|
| フルテキストURL | 79_6_413.pdf |
| 著者 | Jiang, Zhiyun| Xi, Ying| |
| 抄録 | Several observational studies suggested that migraine headache attacks were associated with coronavirus disease 2019 (COVID-19). We investigated genetic causal links between COVID-19 phenotypes and the development of headache and migraine, including migraine with aura (MA) and migraine without aura (MO). We conducted a two-sample Mendelian randomization (MR) analysis to estimate the genetic association in European populations. The inverse-variance weighted (IVW) method was used as the main approach in the MR analyses, together with weighted median and MR-Egger methods. We also performed a series of sensitivity tests to assess the robustness of the MR results. The MR results demonstrated that COVID-19 severity, hospitalization, and susceptibility had no causal effect on the risks of headache, migraine, MA, or MO. No horizontal pleiotropy was detected, and the results were robust as supported by the sensitivity analysis findings. Our analyses identified no casual effect of COVID-19 severity, hospitalization, or susceptibility on the risks of headache or migraine in European populations. |
| キーワード | headache migraine Mendelian randomization COVID-19 |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-12 |
| 巻 | 79巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 413 |
| 終了ページ | 419 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 41443802 |
| Web of Science KeyUT | 001674277500002 |
| JaLCDOI | 10.18926/AMO/69842 |
|---|---|
| フルテキストURL | 79_6_405.pdf |
| 著者 | Ouchi, Chihiro| Morizane Hosokawa, Mio| Kimura, Shuhei| Shiode, Yusuke| Matoba, Ryo| Morita, Tetsuro| Morizane, Yuki| |
| 抄録 | We investigated the treatment outcomes of patients aged ≥85 years with neovascular age-related macular degeneration (nAMD) who received anti-vascular endothelial growth factor (anti-VEGF) therapy using either treat-and-extend (TAE) or pro re nata (PRN) regimens for 1 year in real-world clinical practice. Eighty-five eyes from 85 patients were included. Among them, types 1, 2, and 3 macular neovascularization and polypoidal choroidal vasculopathy were present in 27.1%, 17.6%, 18.8%, and 36.5%, respectively. TAE and PRN regimens were used in 43.5% and 56.5% of patients, respectively. At baseline, the PRN group was older and had worse best-corrected visual acuity (BCVA), greater central retinal thickness, and more intraretinal fluid than the TAE group. In the TAE group, the mean number of injections was 7.6, BCVA improved significantly, and all retinal fluid rates decreased. In the PRN group, the mean number of injections was 3.9, BCVA remained unchanged, and the rates of macular fibrosis and atrophy increased. No serious adverse events were observed in either group. Anti-VEGF therapy was safe for patients aged ≥ 85 years with nAMD, and the TAE regimen effectively improved BCVA in this population. BCVA remained unchanged in the PRN-treated patients, with baseline disease severity and/or undertreatment potentially influencing the outcomes. |
| キーワード | anti-vascular endothelial growth factor therapy neovascular age-related macular degeneration age treat-and-extend pro re nata |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-12 |
| 巻 | 79巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 405 |
| 終了ページ | 412 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 41443801 |
| Web of Science KeyUT | 001674277500001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Arakawa, Kyosuke| Nakagawa, Masayuki| Abe, Yoichiro| Morimatsu, Hiroshi| |
| キーワード | Herpes zoster Magnetic resonance imaging Postherpetic neuralgia Refractory zoster-associated pain Temporary spinal cord stimulation |
| 発行日 | 2025-02-20 |
| 出版物タイトル | Journal of Anesthesia |
| 巻 | 39巻 |
| 号 | 2号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 273 |
| 終了ページ | 281 |
| ISSN | 0913-8668 |
| NCID | AA10852931 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2025 |
| 論文のバージョン | publisher |
| PubMed ID | 39976687 |
| DOI | 10.1007/s00540-025-03458-1 |
| Web of Science KeyUT | 001427457500001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s00540-025-03458-1 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nukaya, Takuhisa| Takahara, Kiyoshi| Toyoda, Shingo| Inoki, Lan| Fukuokaya, Wataru| Mori, Keiichiro| Iwata, Takehiro| Bekku, Kensuke| Maenosono, Ryoichi| Tsujino, Takuya| Hirasawa, Yosuke| Yanagisawa, Takafumi| Hashimoto, Takeshi| Komura, Kazumasa| Araki, Motoo| Fujita, Kazutoshi| Ohno, Yoshio| Shiroki, Ryoichi| |
| キーワード | cytoreductive nephrectomy IMDC classification immune checkpoint inhibitor neutrophil-to- lymphocyte ratio sarcomatoid differentiation |
| 発行日 | 2025-08-19 |
| 出版物タイトル | International Journal of Urology |
| 巻 | 32巻 |
| 号 | 11号 |
| 出版者 | Wiley |
| 開始ページ | 1677 |
| 終了ページ | 1685 |
| ISSN | 0919-8172 |
| NCID | AA11042471 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 40831087 |
| DOI | 10.1111/iju.70207 |
| Web of Science KeyUT | 001610691000032 |
| 関連URL | isVersionOf https://doi.org/10.1111/iju.70207 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Sako, Hidefumi| Omori, Kazuhiro| Shinoda-Ito, Yuki| Takabatake, Kiyofumi| Nagatsuka, Hitoshi| Takashiba, Shogo| |
| キーワード | calcium hydroxide immature permanent teeth pulp necrosis regenerative endodontic therapy revascularization |
| 発行日 | 2025-10-29 |
| 出版物タイトル | Cureus |
| 巻 | 17巻 |
| 号 | 10号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | e95647 |
| ISSN | 2168-8184 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © Copyright 2025 Sako et al. |
| 論文のバージョン | publisher |
| DOI | 10.7759/cureus.95647 |
| 関連URL | isVersionOf https://doi.org/10.7759/cureus.95647 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yasui, Kazuya| Takagi, Kosei| Fuji, Tomokazu| Nishiyama, Takeyoshi| Nagai, Yasuo| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Fujii, Yuki| Otsuka, Motoyuki| Fujiwara, Toshiyoshi| |
| キーワード | neoadjuvant chemotherapy pancreatic cancer resectable textbook outcome |
| 発行日 | 2025-10-10 |
| 出版物タイトル | Cancers |
| 巻 | 17巻 |
| 号 | 20号 |
| 出版者 | MDPI AG |
| 開始ページ | 3287 |
| ISSN | 2072-6694 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 by the authors. |
| 論文のバージョン | publisher |
| DOI | 10.3390/cancers17203287 |
| 関連URL | isVersionOf https://doi.org/10.3390/cancers17203287 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nagamine, Masanori| Nakao, Tomoyo| van Bergen, Leo| Shigemura, Jun| Saito, Taku| van der Does, Florentine H.S.| Kitano, Masato| Giltay, Erik J.| van der Wee, Nic J.| Vermetten, Eric| |
| キーワード | Psychotrauma World War II Japan Europe KZ syndrome Post-traumatic stress disorder |
| 発行日 | 2025-06 |
| 出版物タイトル | Asian Journal of Psychiatry |
| 巻 | 108巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 104508 |
| ISSN | 1876-2018 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 40287989 |
| DOI | 10.1016/j.ajp.2025.104508 |
| Web of Science KeyUT | 001482303000001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.ajp.2025.104508 |
| JaLCDOI | 10.18926/AMO/69442 |
|---|---|
| フルテキストURL | 79_5_399.pdf |
| 著者 | Isozaki, Hiroshi| Matsumoto, Sasau| Takama, Takehiro| Isozaki, Yuka| Murakami, Shigeki| |
| 抄録 | Gastric cancer with lymphoid stroma (GCLS) accounts for 1%-7% of gastric cancers; ~80% are Epstein-Barr virus (EBV)-positive. The rate of lymph node metastasis is relatively low, even when an early GCLS has invaded the submucosa. We report an early GCLS with massive submucosal invasion mimicking a submucosal tumor (SMT), diagnosed by endoscopic submucosal resection (ESD) and treated with local resection and sentinel node navigation surgery (SNNS). The patient was a 40-year-old Japanese man. A protruding lesion on the greater curvature of the middle part of his stomach was detected by X-ray, and an endoscopic examination revealed a 2.5-cm protruding tumor covered with a normal mucosa and small ulcers at the apex. ESD was performed for a diagnosis. The pathological diagnosis was lymphoepithelioma-like gastric cancer (GCLS), pT1b(SM2), Ly0, V0, pHM1, pVM1. EBV infection in the cancer cells was confirmed pathologically by EBV-encoded RNA. The local resection was performed using SNNS. The patient has had no recurrence or post-gastrectomy syndrome 4 years postsurgery. EBV-associated early GCLS resembling an SMT is relatively rare, and clinicians need to be aware of this disease. Local resection using SNNS may be a surgical option for GCLS cases with a low rate of lymphatic metastasis. |
| キーワード | gastric cancer gastric cancer with lymphoid stroma lymphoepithelioma-like carcinoma Epstein Barr virus sentinel node navigation surgery |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-10 |
| 巻 | 79巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 399 |
| 終了ページ | 404 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 41126472 |
| Web of Science KeyUT | 001606012000001 |
| JaLCDOI | 10.18926/AMO/69440 |
|---|---|
| フルテキストURL | 79_5_387.pdf |
| 著者 | Mori, Yusuke| Otani, Yoshihiro| Omae, Ryo| Hirano, Shuichiro| Ishida, Joji| Fujii, Kentaro| Haruma, Jun| Hiramatsu, Masafumi| Matsushita, Toshi| Higaki, Fumiyo| Sugiu, Kenji| Tanaka, Shota| |
| 抄録 | Trigonal meningiomas are rare and pose surgical challenges due to their deep location and proximity to critical neuroanatomical structures. We present the case of a 67-year-old woman with a growing trigonal meningioma successfully resected with guidance by a preoperative 3D imaging analysis system. Integration of CT and MRI including diffusion tensor imaging (DTI) enabled precise mapping of the optic radiation, guiding a middle temporal gyrus approach. Preoperative embolization reduced tumor vascularity, facilitating gross total resection with minimal blood loss. This case highlights the effectiveness of preoperative 3D imaging systems in optimizing surgical planning and improving outcomes in complex neurosurgical cases. |
| キーワード | trigonal meningioma imaging analysis diffusion tensor imaging |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-10 |
| 巻 | 79巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 387 |
| 終了ページ | 392 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 41126470 |
| Web of Science KeyUT | 001606011100001 |
| JaLCDOI | 10.18926/AMO/69439 |
|---|---|
| フルテキストURL | 79_5_381.pdf |
| 著者 | Sakurai, Atsunobu| Yabuki, Takayuki| Aoki, Hideki| Iseki, Akiko| |
| 抄録 | We report the case of a 72-year-old Japanese man with an incidental portal vein mass that was surgically resected and diagnosed as immunoglobulin G4 (IgG4)-related disease. The mass was discovered during an atrial fibrillation examination. The patient had a history of gastric cancer and was also diagnosed with rectal cancer, raising concerns about metastasis. Due to technical challenges, a biopsy was not feasible. Imaging findings suggested portal vein tumor thrombosis, complicating the diagnosis. This case highlights a rare presentation of IgG4-related disease mimicking portal vein tumor thrombus. |
| キーワード | immunoglobulin G4-related disease inflammatory pseudotumor mass portal vein pericarditis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-10 |
| 巻 | 79巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 381 |
| 終了ページ | 385 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 41126469 |
| Web of Science KeyUT | 001606015100001 |
| JaLCDOI | 10.18926/AMO/69438 |
|---|---|
| フルテキストURL | 79_5_369.pdf |
| 著者 | Hisamatsu, Takashi| Kinuta, Minako| Munetomo, Sosuke| Fukuda, Mari| Kojima, Katsuhide| Taniguchi, Kaori| Nakahata, Noriko| Kanda, Hideyuki| |
| 抄録 | We applied unsupervised machine learning to analyze blood pressure (BP) and resting heart rate (HR) patterns measured during a 1-year period to assess their cross-sectional relationships with subclinical cerebral and renal target damage. Dimension reduction via uniform manifold approximation and projection, followed by K-means++ clustering, was used to categorize 362 community-dwelling participants (mean age, 56.2 years; 54.9% women) into three groups: Low BP and Low HR (Lo-BP/Lo-HR), High BP and High HR (Hi-BP/Hi-HR), and Low BP and High HR (Lo-BP/Hi-HR). Cerebral vessel lesions were defined as the presence of at least one of the following magnetic resonance imaging findings: lacunar infarcts, white matter hyperintensities, cerebral microbleeds, or intracranial artery stenosis. A high urinary albumin-to-creatinine ratio (UACR) was defined as the top 10% (≥ 12 mg/g) of the mean value from ≥2 measurements. Poisson regression with robust error variance, adjusted for demographics, lifestyle, and medical history, showed that the Hi-BP/Hi-HR group had relative risks of 3.62 (95% confidence interval, 1.75-7.46) for cerebral vessel lesions and 3.58 (1.33-9.67) for high UACR, and the Lo-BP/Hi-HR group had a relative risk of 3.09 (1.12-8.57) for high UACR, compared with the Lo-BP/Lo-HR group. These findings demonstrate the utility of an unsupervised, data-driven approach for identifying physiological patterns associated with subclinical target organ damage. |
| キーワード | blood pressure heart rate subclinical disease uniform manifold approximation and projection unsupervised machine learning |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-10 |
| 巻 | 79巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 369 |
| 終了ページ | 379 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 41126468 |
| Web of Science KeyUT | 001606013200007 |
| JaLCDOI | 10.18926/AMO/69437 |
|---|---|
| フルテキストURL | 79_5_359.pdf |
| 著者 | Hirose, Tomohiko| Ikuma, Hisanori| Otsuka, Kazutoshi| Kawasaki, Keisuke| |
| 抄録 | Single-position surgery with lateral lumbar interbody fusion (LLIF) and percutaneous pedicle screws (PPSs) is gaining attention for its reduced invasiveness. We developed SPAPS, a technique allowing two surgeons to perform anterior LLIF and posterior PPS insertion simultaneously in a single lateral decubitus position. This retrospective study compared SPAPS (SPAPS-LLIF, Group SL) and minimally invasive posterior/transforaminal lumbar interbody fusion (MIS-PLIF/TLIF, Group PT) in patients treated between 2016 and 2019 with a two-year follow-up. Operative time, estimated blood loss (EBL), length of hospital stay (LOS), JOABPEQ and VAS scores, segmental lordotic angle, lumbar lordotic angle, segmental Cobb’s angle, PPS misplacement, PPS loosening, fusion status, and muscle cross-sectional areas were compared. Fifty-two patients were analyzed (Group SL: 25; Group PT: 27). SPAPS significantly reduced operative time (118.0 vs. 165.3 min, p <0.01) and estimated blood loss (8.6 vs. 164.1 mL, p<0.01). While clinical outcomes and hospital stay were comparable, Group SL had significantly lower PPS loosening (0% vs. 13%, p<0.01) and non-union rates (0% vs. 22.2%, p=0.02). Multifidus muscle atrophy was also less in Group SL (−14.3 vs. −121.5 mm2, p<0.01). SPAPS demonstrated advantages in reducing surgical invasiveness without compromising clinical efficacy, offering a promising alternative to conventional posterior fusion surgery. |
| キーワード | single-position surgery simultaneous lateral decubitus positioning lateral lumbar interbody fusion posterior lumbar interbody fusion |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-10 |
| 巻 | 79巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 359 |
| 終了ページ | 368 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 41126467 |
| Web of Science KeyUT | 001606013200006 |
| JaLCDOI | 10.18926/AMO/69436 |
|---|---|
| フルテキストURL | 79_5_353.pdf |
| 著者 | Chihara, Yuki| Hamasaki, Ichiro| Shibata, Kiyo| Morisawa, Shin| Kono, Reika| Kanenaga, Keisuke| Morizane, Yuki| |
| 抄録 | To analyze and characterize the medial and lateral rectus muscles in patients with exotropia using anterior segment optical coherence tomography (AS-OCT). This study included 24 patients with exotropia (48 eyes) and 25 healthy individuals (50 eyes). Anterior segment optical coherence tomography was used to construct the en face images. The anterior chamber angle to the extraocular muscle insertion distance, muscle width, and muscle fiber angle from the muscle insertion sites were compared between the exotropia and the control groups. The correlation between these parameters and age or angle of deviation was evaluated. The mean ages were 13.2±4.1 years for the exotropia group and 17.6±7.2 years for the control group. The lateral rectus angle was significantly more inwardly rotated in the exotropia group than in the control group (1.6±6.3°, −1.4±4.0°, p=0.014). With increasing angle of deviation, the width of the lateral rectus increased (p=0.002). Our results indicate that the lateral rectus angle is significantly more inwardly rotated in patients with exotropia. These findings should contribute to a deeper understanding of the extraocular muscles in patients with this condition. |
| キーワード | exotropia AS-OCT anterior chamber angle to extraocular muscle insertion distance muscle width muscle fiber angle |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-10 |
| 巻 | 79巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 353 |
| 終了ページ | 358 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 41126466 |
| Web of Science KeyUT | 001606013200005 |
| JaLCDOI | 10.18926/AMO/69435 |
|---|---|
| フルテキストURL | 79_5_345.pdf |
| 著者 | Matsunaga, Nozomu| Egusa, Seira| Aono, Riyo| Tamai, Eiji| Hitusmoto, Yasuo| Katayama, Seiichi| |
| 抄録 | Clostridium perfringens is a pathogenic anaerobe that causes gas gangrene and food poisoning. Although autolysin-mediated reorganization of the bacterial cell wall is crucial for cell division, excessive autolysin activity induced by stressors can lead to cell lysis. In C. perfringens, air exposure is a significant stressor that causes cell lysis, and Acp (N-acetylglucosaminidase) is known to be a major autolysin. To further facilitate C. perfringens research, a technology to prevent air-induced cell lysis must be developed. This study investigated the role of Acp in air-induced autolysis and explored potential inhibitors that would prevent cell lysis during experimental procedures. Morphological analyses confirmed that Acp functions as an autolysin in C. perfringens, as acpdeficient strains exhibited filamentous growth. The mutants exhibited negligible autolysis under air-exposure stress, confirming the involvement of Acp in the autolytic process. We also evaluated the effects of various divalent cations on Acp activity in vitro and identified Zn2+ as a potent inhibitor. Brief treatment with a Zn2+- containing buffer induced dose-dependent cell elongation and autolysis inhibition in C. perfringens. These findings demonstrate that simple Zn2+ treatment before experiments stabilizes C. perfringens cells, reducing autolysis under aerobic conditions and facilitating various biological studies, except morphological analyses. |
| キーワード | Clostridium perfringens autolysin zinc air-exposure autolysis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-10 |
| 巻 | 79巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 345 |
| 終了ページ | 352 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 41126465 |
| Web of Science KeyUT | 001606013200004 |
| JaLCDOI | 10.18926/AMO/69433 |
|---|---|
| フルテキストURL | 79_5_329.pdf |
| 著者 | Matsubara, Kei| Miyoshi, Kentaroh| Toyooka, Shinichi| |
| 抄録 | Primary graft dysfunction (PGD) is one of the major risk factors affecting patients’ short- and long-term survival after lung transplantation. No particular management strategy has been established for PGD; supportive care is the mainstay of PGD treatment. When a supportive strategy fails, the patient may require the introduction of extracorporeal membrane oxygenation (ECMO) as the last-resort measure for severe PGD. A variety of study of ECMO as a PGD treatment was reported and the management of PGD patients developed so far. Early recognition of a patient’s need for ECMO and its prompt initiation are critical to improved outcomes. The use of venovenous-ECMO became the preferred procedure for PGD rather than venoarterial-ECMO. However, the current ECMO strategy has limitations, and using ECMO to manage patients with PGD is not sufficiently effective. Further studies are required to develop this promising technology. |
| キーワード | lung transplantation primary graft dysfunction extracorporeal membrane oxygenation ex vivo lung perfusion |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-10 |
| 巻 | 79巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 329 |
| 終了ページ | 337 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 41126463 |
| Web of Science KeyUT | 001606013200002 |
| JaLCDOI | 10.18926/AMO/69432 |
|---|---|
| フルテキストURL | 79_5_321.pdf |
| 著者 | Obata, Taisuke| Matsumoto, Kazuyuki| Otsuka, Motoyuki| |
| 抄録 | Bile leak occurs in 2-25% of liver transplant, 3-27% of hepatic resection, and 0.1-4% of cholecystectomy cases. The clinical course of bile leak varies depending on the type of surgery that caused the fistula, as well as the type, severity, and timing of bile duct injury. Although infections resulting from bile leak can be life-threatening, the introduction of endoscopic treatment has enabled some patients to avoid reoperation and has reduced the negative impact on quality of life associated with external fistulas for percutaneous drainage. Endoscopic interventions, such as sphincterotomy and stent placement, reduce the pressure gradient between the bile duct and duodenum, facilitating bile drainage through the papilla and promoting the closure of the leak. We reviewed the literature from 2004 to 2024 regarding bile leak following cholecystectomy and liver surgery, examining recommended techniques, timing, and treatment outcomes. In cases of bile leak following cholecystectomy, clinical success was achieved in 72-96% of cases, while success rates for bile leak following liver surgery ranged from 50% to 100%. Although endoscopic treatment is effective, it is not universally applicable, and its limitations must be carefully considered. |
| キーワード | bile leak cholecystectomy hepatic surgery endoscopic retrograde cholangiography bridging stent placement |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-10 |
| 巻 | 79巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 321 |
| 終了ページ | 328 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 41126462 |
| Web of Science KeyUT | 001606013200001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Iwai, Komei| Ekuni, Daisuke| Azuma, Tetsuji| Yonenaga, Takatoshi| Tabata, Koichiro| Toyama, Naoki| Kataoka, Kota| Maruyama, Takayuki| Tomofuji, Takaaki| |
| キーワード | oral health liver diseases longitudinal studies mastication physical examination surveys and questionnaires |
| 発行日 | 2025-06-11 |
| 出版物タイトル | Healthcare |
| 巻 | 13巻 |
| 号 | 12号 |
| 出版者 | MDPI AG |
| 開始ページ | 1399 |
| ISSN | 2227-9032 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 40565426 |
| DOI | 10.3390/healthcare13121399 |
| Web of Science KeyUT | 001514847500001 |
| 関連URL | isVersionOf https://doi.org/10.3390/healthcare13121399 |
| フルテキストURL | fulltext.pdf suppl.docx |
|---|---|
| 著者 | Shien, Tadahiko| Hara, Fumikata| Aogi, Kenjiro| Yanagida, Yasuhiro| Tsuneizumi, Michiko| Yamamoto, Naohito| Matsumoto, Hiroshi| Suto, Akihiko| Watanabe, Kenichi| Harao, Michiko| Kanbayashi, Chizuko| Itoh, Mitsuya| Kadoya, Takayuki| Anan, Keisei| Maeda, Shigeto| Sasaki, Keita| Ogawa, Gakuto| Saji, Shigehira| Fukuda, Haruhiko| Iwata, Hiroji| |
| 発行日 | 2025-07-04 |
| 出版物タイトル | British Journal of Cancer |
| 出版者 | Springer Science and Business Media LLC |
| ISSN | 0007-0920 |
| NCID | AA00574355 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2025 |
| 論文のバージョン | publisher |
| PubMed ID | 40615712 |
| DOI | 10.1038/s41416-025-03097-z |
| Web of Science KeyUT | 001523009900001 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41416-025-03097-z |