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JaLCDOI 10.18926/AMO/66928
フルテキストURL 78_2_193.pdf
著者 Kashima, Hajime| Teraishi, Fuminori| Matsumi, Yuki| Shimamura, Hiroshi| Fujiwara, Toshiyoshi|
抄録 Tailgut cyst is a rare cystic disease of the anterior sacral surface and the remains of an embryonic tail gut. Tailgut cysts have a potential for malignancy, and complete resection with an adequate surgical margin is necessary. Even if incomplete resection does not result in recurrence of malignant disease, there is a risk of local infection leading to refractory fistulas. The optimal treatment for such refractory recurrent lesions has not been reported. We describe a case in which the combination of laparoscopic and transsacral approaches was effective for resecting a recurrent refractory fistula after incomplete resection of a tail gut cyst.
キーワード tailgut cyst laparoscopic resection fistula formation
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2024-04
78巻
2号
出版者 Okayama University Medical School
開始ページ 193
終了ページ 196
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38688837
Web of Science KeyUT 001227932200003
JaLCDOI 10.18926/AMO/66915
フルテキストURL 78_2_123.pdf
著者 Saeki, Kyosuke| Fujiwara, Hideaki| Seike, Keisuke| Kuroi, Taiga| Nishimori, Hisakazu| Tanaka, Takehiro| Matsuoka, Ken-ichi| Fujii, Nobuharu| Maeda, Yoshinobu|
抄録 Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT.
キーワード GVHD posttransplant cyclophosphamide hematopoietic cell transplantation HLA-identical
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-04
78巻
2号
出版者 Okayama University Medical School
開始ページ 123
終了ページ 134
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38688830
Web of Science KeyUT 001229151800004
JaLCDOI 10.18926/AMO/66675
フルテキストURL 78_1_085.pdf
著者 Miyake, Keisuke| Tanikawa, Tomohiro| Haruma, Ken| Kawada, Mayuko| Ishii, Katsunori| Urata, Noriyo| Nishino, Ken| Suehiro, Mitsuhiko| Kawanaka, Miwa| Manabe, Noriaki| Kawamoto, Hirofumi|
抄録 A 30-year-old man with idiopathic peptic ulcer disease (IPUD) experienced repeated recurrence of ulcerative bleeding despite treatment with lansoprazole and then vonoprazan. Further evaluation suggested that the cause of the ulcer was strong contractile movements of the antrum. This prompted the co-administration of trimebutine maleate (TM) and vonoprazan to relieve the stomach contractions. TM was effective in preventing the recurrence of ulcerative bleeding, and the patient has remained in remission for 4 years. This case highlights the potential efficacy of TM in treating IPUD and the importance of considering hypercontractility as the underlying cause in cases of IPUD.
キーワード gastric ulcer idiopathic peptic ulcerative disease trimebutine maleate
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2024-02
78巻
1号
出版者 Okayama University Medical School
開始ページ 85
終了ページ 88
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38419319
Web of Science KeyUT 001204421300002
JaLCDOI 10.18926/AMO/66149
フルテキストURL 77_6_577.pdf
著者 Liu, Siyu| Athurupana, Rukmali| Han, Hongmei| Yang, Titi| Nakatsuka, Mikiya|
抄録 Bereavement care is conducted to meet the emotional needs of grieving couples who are devastated by the experience of a miscarriage or stillbirth. From January to April 2022, we distributed a questionnaire that assessed the knowledge and attitudes of Japanese nursing staff (nurses and midwives) in Japan’s Chugoku-Shikoku region toward bereavement care for couples with miscarriage/stillbirth. The 370 survey respondents’ answers revealed that the nursing staff’s knowledge regarding recurrent pregnancy loss and subsequent bereavement care was insufficient. About 41.1% and 64.1% of the respondents had received school and on-the-job education in bereavement care, respectively, and 79.2% expressed willingness to provide such care. Our analyses revealed that the following factors were associated with the nursing staff’s knowledge level: parent status, age, reproductive history, midwifery license, work experience and environment, and on-the-job education. The following were correlated with the staff’s willingness to provide bereavement care: work environment, midwifery license, bereavement care knowledge, and on-the-job education. Together our findings indicate that education plays a significant role in equipping caregivers to provide effective bereavement care for couples who have experienced a miscarriage or stillbirth.
キーワード midwife nurse miscarriage bereavement knowledge
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-12
77巻
6号
出版者 Okayama University Medical School
開始ページ 577
終了ページ 587
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38145931
Web of Science KeyUT 001164631200002
JaLCDOI 10.18926/AMO/65968
フルテキストURL 77_5_461.pdf
著者 Homma, Daisuke| Minato, Izumi| Imai, Norio| Miyasaka, Dai| Sakai, Yoshinori| Horigome, Yoji| Suzuki, Hayato| Dohmae, Yoichiro| Endo, Naoto|
抄録 This study aimed to determine which muscle the gluteus maximus, gluteus medius, gluteus minimus (Gmin), or tensor fasciae latae (TFL) contributes most to hip abduction strength and to identify effective sites for cross-sectional area (CSA) Gmin and TFL measurement in hip osteoarthritis (OAhip) patients. Twenty-eight patients with OAhip were included. The muscle CSA and volume were determined using magnetic resonance imaging. Peak isometric strength was determined using hand-held dynamometry. Muscle volumes were normalized to the total muscle volume of hip abductors. Multiple regression analysis was performed. The difference between the CSA of Gmin and TFL was calculated, and correlations with volume and muscle strength were determined. Gmin volume was related to abductor muscle strength (p=0.042). The peak CSA of the Gmin correlated with muscle volume and strength. The CSA of the TFL correlated with volume, with no difference between the CSA of the most protruding part of the lesser trochanter and peak CSA. Gmin volume was strongly related to abductor muscle strength. Peak CSA is a useful parameter for assessing the CSA of the Gmin among patients with OAhip. The CSA of the TFL should be measured at the most protruding part of the lesser trochanter.
キーワード gluteus minimus tensor fasciae latae cross-sectional area muscle volume hip osteoarthritis
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-10
77巻
5号
出版者 Okayama University Medical School
開始ページ 461
終了ページ 469
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37899257
Web of Science KeyUT 001108661600003
JaLCDOI 10.18926/AMO/65750
フルテキストURL 77_4_395.pdf
著者 Pavlovic, Marko| Babic, Dragan| Rastovic, Pejana| Arapovic, Jurica| Martinac, Marko| Jakovac, Sanja| Barbaric, Romana|
抄録 We investigated the relationship between serum tumor necrosis factor-alpha (TNF-α) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-α levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-α levels were detected between the patients and controls (p=0.736). TNF-α levels were not correlated with total, positive, negative, general, or composite PANSS scores (all p>0.05). A significant negative correlation was observed between TNF-α levels and the PANSS cognitive factor (ρ=−0.222, p=0.035). A hierarchical regression analysis identified the cognitive factor as a significant predictor of the TNF-α level (beta=−0.258, t=−2.257, p=0.027). There were no significant differences in TNF-α levels among patients treated with different types of antipsychotics (p=0.596). TNF-α levels correlated positively with the age of onset (ρ=0.233, p=0.027) and negatively with illness duration (ρ=−0.247, p=0.019) and antipsychotic treatment duration (ρ=−0.256, p=0.015). These results indicate that TNF-α may be involved in cognitive impairment in schizophrenia, and would be a potential clinical-state marker in schizophrenia.
キーワード tumor necrosis factor-alpha schizophrenia psychopathology immune system
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-08
77巻
4号
出版者 Okayama University Medical School
開始ページ 395
終了ページ 405
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37635140
Web of Science KeyUT 001163659800010
フルテキストURL K0006791_abstract_review.pdf K0006791_fulltext.pdf K0006791_summary.pdf
著者 千田 真友子|
発行日 2023-03-24
資料タイプ 学位論文
学位授与番号 甲第6791号
学位授与年月日 2023-03-24
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
JaLCDOI 10.18926/AMO/65142
フルテキストURL 77_2_131.pdf
著者 Senda, Mayuko| Terada, Seishi| Fujiwara, Masaki| Yamada, Norihito|
抄録 Eating disorders (EDs) are associated with a high mortality rate. Patients with EDs often experience severe dehydration due to food restriction and/or vomiting. Severely underweight patients are often prescribed bed rest during inpatient care to reduce their energy consumption, and they may thus develop multiple risk factors for venous thromboembolism (VTE). We compared the clinical features of ED inpatients with VTE to those of ED inpatients without VTE. Seventy-one inpatients with ED were treated at Okayama University Hospital’s psychiatric ward in 2016-2020; five were experienced a VTE. Compared to the non-VTE group, the VTE group’s median age and disease duration were greater and the median body mass index (BMI) was lower. The VTE group’s D-dimer peak values were > 5 mg/L. Physical restraint and central venous catheter use were associated with VTE. Longer ED duration and lower BMI might be risk factors for VTE. To make inpatient treatment for ED safer, it is important to avoid the use of physical restraints and central venous catheters. Continuous D-dimer monitoring is necessary for the early detection of VTE in ED patients at high risk of VTE.
キーワード eating disorder anorexia nervosa venous thromboembolism deep vein thrombosis
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-04
77巻
2号
出版者 Okayama University Medical School
開始ページ 131
終了ページ 137
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37094950
Web of Science KeyUT 000982503800002
JaLCDOI 10.18926/AMO/64357
フルテキストURL 77_1_21.pdf
著者 Homma, Daisuke| Minato, Izumi| Imai, Norio| Miyasaka, Dai| Sakai, Yoshinori| Horigome, Yoji| Suzuki, Hayato| Dohmae, Yoichiro| Endo, Naoto|
抄録 We measured the muscle mass and phase angle of each body part to evaluate the relationship between balance and gait functions in individuals with a pre-frailty status. This cross-sectional observational study determined the skeletal muscle mass-to-body weight ratio and phase angles of 21 control (robust) and 29 pre-frail subjects. Their Brief-Balance Evaluation Systems Test, Timed Up-and-Go (TUG) test, Life-Space Assessment, and Modified Fall Efficacy Scale scores plus the relationship between muscle mass, phase angle, and motor function were evaluated. In the pre-frailty group (three males, 26 females, aged 75.58±7.60 years), significant correlations were noted between the Brief-Balance Evaluation Systems Test score and lower-limb (r=0.614) and wholebody (r=0.557) phase angles, and between the TUG test score and lower-limb muscle mass-to-body weight ratio (r=−0.616), lower-limb phase angle (r=−0.616), and whole-body phase angle (r=−0.527). Evaluating the phase angle of the lower extremities of pre-frail patients and intervening accordingly may help clinicians maintain and improve these patients’ balance and gait functions.
キーワード bioelectrical impedance analysis motor function muscle quality muscle volume
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-02
77巻
1号
出版者 Okayama University Medical School
開始ページ 21
終了ページ 27
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 36849142
Web of Science KeyUT 000953663800003
フルテキストURL fulltext20230207-2.pdf
著者 Chau, Tran Thi Minh| Someya, Takashi| Akao, Satoshi| Nakamura, Masato| Oritate, Fumiko| Somura, Hiroaki| Yamane, Shinzo| Maeda, Morihiro|
キーワード Aerobic conditions greenhouse gas emissions kitchen waste compost
備考 This is an Accepted Manuscript of an article published by Taylor & Francis in [Soil Science and Plant Nutrition] on 10 Jan 2023, available at: http://www.tandfonline.com/10.1080/00380768.2022.2160622| This full-text file will be available in Jan. 2024.|
発行日 2023-01-10
出版物タイトル Soil Science and Plant Nutrition
69巻
2号
出版者 Informa UK Limited
開始ページ 137
終了ページ 147
ISSN 0038-0768
NCID AA00844314
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2023 Japanese Society of Soil Science and Plant Nutrition
論文のバージョン author
DOI 10.1080/00380768.2022.2160622
Web of Science KeyUT 000912052500001
関連URL isVersionOf https://doi.org/10.1080/00380768.2022.2160622
JaLCDOI 10.18926/64300
タイトル(別表記) Effects of Time Attitude, Time Frequency, and Time Orientation on Depressive Tendency
フルテキストURL hss_054_137.pdf
著者 張 澤| 堀内 孝|
出版物タイトル 岡山大学大学院社会文化科学研究科紀要
発行日 2022-12-23
54巻
開始ページ 137
終了ページ 151
ISSN 1881-1671
言語 日本語
著作権者 Copyright (c) 2022 岡山大学大学院社会文化科学研究科
論文のバージョン publisher
JaLCDOI 10.18926/AMO/64121
フルテキストURL 76_6_705.pdf
著者 Higashikawa, Toshihiro| Ito, Tomohiko| Mizuno, Takurou| Ishigami, Keiichiro| Kuroki, Kengo| Maekawa, Naoto| Usuda, Daisuke| Izumida, Toshihide| Yamada, Shinya| Sangen, Ryusho| Hamada, Kazu| Kiyosawa, Jun| Saito, Atsushi| Iguchi, Masaharu| Kasamaki, Yuji| Nakahashi, Takeshi| Fukuda, Akihiro| Saito, Hitoshi| Kanda, Tsugiyasu| Okuro, Masashi|
抄録 The sodium glucose transporter 2 (SGLT2) inhibitor tofogliflozin is a glucose-lowering drug that causes the excretion of surplus glucose by inhibiting SGLT2. Because of tofogliflozin’s osmotic diuresis mechanism, patients’ serum electrolytes, body fluid levels, and cardiac function must be monitored. We retrospectively analyzed the cases of 64 elderly Japanese patients with type 2 diabetes mellitus (T2DM) who received tofogliflozin for 3 months. Their HbA1c, serum electrolytes (sodium, potassium, chloride), hematocrit, brain natriuretic peptide (cardiac volume load marker) and renin and aldosterone (RAA; an index of regulatory hormones involved in body fluid retention) were continuously monitored during the investigation period. Renal function and cardiac function (by echocardiography) were assessed throughout the period. HbA1c significantly decreased (β1=−0.341, p<0.0001, linear regression analysis [LRA]). Most of the hormonal, electrolyte, and physiological parameters were maintained throughout the study period. In these circumstances, E/e’ tended to decrease (β1=−0.382, p=0.13, LRA). Compared to the baseline, E/e’ was significantly decreased at 1 and 3 months (p<0.01, p<0.05). In the higher E/e’ group (E/e’≥10, n=34), E/e’ decreased significantly (β1=−0.63, p<0.05, LRA). ΔE/e’ was correlated with body-weight change during treatment (r=0.64, p<0.01). The 3-month tofogliflozin treatment improved glycemic control and diastolic function represented by E/e’ in T2DM patients, without affecting serum electrolytes, renal function, or RAA. No negative impacts on the patients were observed. Three-month tofogliflozin treatment lowered glucose and improved cardiac diastolic function.
キーワード tofogliflozin SGLT2 inhibitor elderly patient HbA1c cardiac diastolic function
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-12
76巻
6号
出版者 Okayama University Medical School
開始ページ 705
終了ページ 713
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 36549773
Web of Science KeyUT 000905195100011
JaLCDOI 10.18926/AMO/63903
フルテキストURL 76_4_439.pdf
著者 Miyaji, Chikara| Takao, Soshi| Noguchi, Masayuki| Okazaki, Tsubasa| Sato, Shunsuke| Yorifuji, Takashi|
抄録 This study examined the relationship between cognitive/structural social capital and post-traumatic stress disorder (PTSD) among victims of heavy rain and flood. Participants were individuals aged≥18 years affected by the July 2018 heavy rainfall in the cities of Kurashiki and Soja, Japan, and living in temporary housing. We distributed five copies of a questionnaire to 1,991 households and received responses from 1,927 individuals (907 men, 1,008 women, 12 respondents of unspecified sex) in 1,029 households (51.7%). We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between high (vs. low) social capital and PTSD or other outcomes. After covariate adjustment, the odds of having PTSD were lower in participants with high cognitive social capital than those with low cognitive social capital (OR=0.346, 95%CI: 0.263-0.456). Elderly women with higher structural social capital tended to have lower PTSD odds than those with lower structural social capital (OR=0.671, 95%CI: 0.431-1.046). The opposite pattern was observed for elderly men (OR=1.315, 95%CI: 0.792-2.183). Cognitive social capital is a protective factor that may reduce PTSD or promote a favorable PTSD prognosis after heavy rainfall and flood events. The associations between structural social capital and PTSD differ by age and sex.
キーワード social capital post-traumatic stress disorder disaster flooding
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-08
76巻
4号
出版者 Okayama University Medical School
開始ページ 439
終了ページ 446
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 36123159
Web of Science KeyUT 000882167300010
JaLCDOI 10.18926/AMO/63902
フルテキストURL 76_4_429.pdf
著者 Yamadori, Yusuke| Hirao, Tomohiro| Nlandu R. Ngatu| Kanda, Kanae| Syed Mahfuz Al Hasan| Murakami, Akitsu| Mashima, Yukinori| Shirakami, Gotaro|
抄録 Blood pressure (BP) often rises before surgery. This study investigated whether BP elevation immediately before surgery was associated with adverse outcomes. Medical records of 11,732 patients (average age: 61 years; male: 47.4%) who underwent non-cardiac elective inpatient surgery under general anesthesia at Kagawa University Hospital between January 2011 and June 2019 were reviewed. Differences between the first BP values measured on the day before surgery and the first BP values in the operating room were defined as Δ systolic BP (ΔSBP) and Δ diastolic BP (ΔDBP). The relationships between ΔSBP/ΔDBP and 30-day mortality, 30-day readmission, and over-the-standard length of hospital stay (OSLOS) were assessed. OSLOS was defined as a hospital stay longer than mean+2 standard deviations and was calculated using the Japanese Diagnosis Procedure Combination data. In univariate analysis, the differences in ΔSBP and ΔDBP between the OSLOS and standard LOS groups were both 2 mmHg. In multivariate logistic regression analysis, only ΔDBP was associated with OSLOS. The adjusted odds ratio (95% confidence interval) for the largest quartile was 1.31 (1.02-1.69) (p<0.05). ΔDBP was associated with OSLOS; however, there may be little need to worry about large ΔSBPs and ΔDBPs in clinical practice.
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-08
76巻
4号
出版者 Okayama University Medical School
開始ページ 429
終了ページ 437
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 36123158
Web of Science KeyUT 000882167300009
JaLCDOI 10.18926/AMO/63745
フルテキストURL 76_3_339.pdf
著者 Yano, Akihiko| Sada, Ken-ei| Sawada, Tsutomu| Ito, Hideki| Yano, Hiroko| Ikeda, Tatsuya|
抄録 A 90-year-old man presented with muscle weakness, difficulty concentrating, and dysphagia. About eighteen months prior to presentation, lansoprazole had been initiated to prevent stress ulcers; he also had a history of total thyroidectomy due to papillary thyroid cancer ten years prior. Laboratory findings were as follows: K 2.4 mEq/L, Ca 3.7 mg/dL, Mg 1.3 mg/dL, CK 5386 U/L, and intact PTH (iPTH) 14 pg/mL. Rhabdomyolysis with multiple electrolyte imbalances under proton pump inhibitor (PPI) treatment was diagnosed. We initiated intravenous hydration and electrolyte supplementation with discontinuation of PPI. After discontinuing PPI, the patient’s serum magnesium, potassium, and calcium levels normalised with oral vitamin D and calcium supplementation. PPIs can cause hypocalcaemia and hypokalaemia via hypomagnesemia; hypocalcaemia is also a common postoperative complication of thyroidectomy. Careful monitoring of electrolyte levels is required in patients with long-term PPI treatment, especially in post-thyroidectomy cases.
キーワード hypocalcaemia thyroidectomy proton pump inhibitors hypomagnesemia rhabdomyolysis
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 339
終了ページ 342
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790366
Web of Science KeyUT 000823568300014
JaLCDOI 10.18926/AMO/63744
フルテキストURL 76_3_333.pdf
著者 Akagawa, Manabu| Miyakoshi, Naohisa| Tsuchie, Hiroyuki| Kasukawa, Yuji| Kawaragi, Takashi| Nagahata, Itsuki| Suzuki, Masazumi| Yoshikawa, Takayuki| Abe, Toshiki| Shimada, Yoichi|
抄録 We report a case of atypical femoral fracture achieving early fracture union with combination therapy comprising contralateral nail and immediate teriparatide injection. Fracture union of atypical fractures is often delayed due to bowing deformity and bone metabolic disorders. Combination treatment that takes both problems into consideration represents a useful treatment option for atypical femoral fracture.
キーワード atypical femoral fracture bowing deformity intramedullary nail teriparatide cephalomedullary screw
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 333
終了ページ 338
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790365
Web of Science KeyUT 000823568300013
JaLCDOI 10.18926/AMO/63738
フルテキストURL 76_3_291.pdf
著者 Miyake, Yoshiaki| Mitani, Shigeru| Namba, Yoshifumi| Umehara, Norifumi| Kawamoto, Toyohiro| Furuichi, Shuro|
抄録 Total hip arthroplasty (THA) provides relief from hip pain and improves hip function. However, periprosthetic joint infection (PJI) remains an area of concern. We examined the detection rate of bacteria from surgical fields in wound closure, along with the relationship between bacterial detection rate and type of antiseptic, surgery time, and surgeon experience for 500 patients who underwent THA at our department. The mean age at surgery was 64.3 (± 27.3) years. The bacterial detection rate was 4.6%. None of the cases revealed PJI. No significant association between the detection rate and type of antiseptic used or surgery time was observed. However, for patients treated by surgeons with < 10 years of orthopedic experience, a detection rate of 7.3% was found, while a rate of 1.3% was observed for those treated by surgeons with ≥ 10 years of orthopedic experience. This finding indicated that orthopedic experience of less than 10 years was significantly associated with an increased bacterial detection rate (chi-square test, p=0.002). The detection rate was associated with surgeon experience but not with antiseptic type or surgery time. It is possible that intraoperative handling may increase the number of bacteria in surgical fields in wound closure.
キーワード total hip arthroplasty bacterial contamination periprosthetic joint infection
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 291
終了ページ 295
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790359
Web of Science KeyUT 000823568300008
JaLCDOI 10.18926/AMO/63407
フルテキストURL 76_2_137.pdf
著者 Tsukahara, Masaru| So, Ryuhei| Yada, Yuji| Kodama, Masafumi| Kishi, Yoshiki| Yamada, Norihito|
抄録 Although reported for Caucasians, changes in plasma clozapine levels after smoking cessation in East Asians remain unclear. We here investigated plasma clozapine levels before and after smoking cessation in Japanese inpatients with schizophrenia. We conducted a retrospective chart review of 14 inpatients with schizophrenia who were being treated with clozapine between June 1, 2019, and July 31, 2019 and who were smokers as of July 1, 2019, the day on which a smoking ban was instituted in the tertiary public psychiatric hospital. The primary outcome was individual differences in plasma clozapine levels between before and after the smoking ban, which were compared using paired t-tests. The mean plasma clozapine level was significantly increased, by 213.4 ng/mL (95% CI 119.9-306.8; p<0.01) or 53.2%. Four of the 14 inpatients experienced clinically significant side effects, such as myoclonus, drooling, and amnesia, due to the development of high plasma clozapine levels. Our findings indicated that close monitoring of plasma clozapine levels before and after smoking cessation and prior dose adjustment of clozapine may be necessary, to prevent a significant risk of developing high plasma clozapine levels, even in Japanese patients.
キーワード Asian clozapine schizophrenia smoking
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-04
76巻
2号
出版者 Okayama University Medical School
開始ページ 137
終了ページ 143
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35503441
Web of Science KeyUT 000792374900005
JaLCDOI 10.18926/bgeou/63248
タイトル(別表記) High School Japanese Language Class Aimed at Developing the Power of Words That Can Be “Critics”
フルテキストURL bgeou_179_137_156.pdf
著者 槇野 滋子|
抄録 本稿は,令和2年度岡山県立総社高等学校家政科1年生を対象とする「国語総合」の授業の実践報告である。稿者は,現在の高等学校国語科の課題克服に向けた指導者の姿勢は「教材への依存度の高さからの脱却」「生徒を真の意味で「主体的な学び」に誘う学習活動の実践」であるとの私見を持っており,本稿では私見にもとづく姿勢で行った1年間の授業について,その概要と教科書所収の文章を「依存から脱出」して教材文として用いた単元の内容を報告した。コロナ禍の影響や評価の面での現場の実態との乖離,稿者の授業作りの「甘さ」等により,成果以上に課題も多く見出せたものの,私見の方向性に間違いがないことが実感できた。
キーワード 「批評者」たり得る言葉の力 「教材への依存度の高さ」からの脱却
出版物タイトル 岡山大学大学院教育学研究科研究集録
発行日 2022-02-24
179巻
開始ページ 137
終了ページ 156
ISSN 1883-2423
言語 日本語
論文のバージョン publisher
JaLCDOI 10.18926/AMO/63213
フルテキストURL 76_1_63.pdf
著者 Zhang, Bei| Pei, Zhixin| Wang, Hongxia| Wu, Huimin| Wang, Junjie| Bai, Junjun| Song, Qinglin|
抄録 We analyzed the treatment effects of chidamide and decitabine in combination with a HAG (homoharringtonine, cytarabine, G-CSF) priming regimen (CDHAG) in acute myeloid leukemia (AML) patients with TP53 mutation. Seven TP53 mutated AML patients were treated with CDHAG. The treatment effects were assessed using hemogram detection and bone marrow aspirate. The possible side effects were evaluated based on both hematological and non-hematological toxicity. Four of the seven patients were classified as having achieved complete remission after CDHAG treatment; one patient was considered to have achieved partial remission, and the remaining two patients were considered in non-remission. The overall response rate (ORR) to CDHAG was 71.4%. Regarding the side effects, the hematological toxicity level of the seven patients ranged from level III to level IV, and infections that occurred at lung, blood, and skin were recorded. Nausea, vomiting, liver injury, and kidney injury were also detected. However, all side effects were attenuated by proper management. The CDHAG regimen clearly improved the ORR (71.4%) of TP53-mutated AML patients, with no severe side effects.
キーワード acute myeloid leukemia chidamide decitabine HAG TP53 mutation
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-02
76巻
1号
出版者 Okayama University Medical School
開始ページ 63
終了ページ 70
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35237000
Web of Science KeyUT 000762812700009