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JaLCDOI 10.18926/AMO/68722
フルテキストURL 79_3_147.pdf
著者 Watanabe, Haruki| Matsumoto, Yoshinori| Wada, Jun|
抄録 Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to “training” for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes.
キーワード systemic lupus erythematosus interferon tricarboxylic acid cycle innate immune memory trained immunity
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2025-06
79巻
3号
出版者 Okayama University Medical School
開始ページ 147
終了ページ 155
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン publisher
査読 有り
フルテキストURL fulltext.pdf
著者 Maruo, Yukinori| Kuwahara, Miho| Yoshihara, Kumiko| Irie, Masao| Nagaoka, Noriyuki| Yoshizane, Mai| Matsumoto, Takuya| Akiyama, Kentaro|
キーワード silane coupling bond strength ceramic feldspathic lithium polymer-infiltrated ceramic CAD/CAM
発行日 2025-04-27
出版物タイトル Materials
18巻
9号
出版者 MDPI
開始ページ 1983
ISSN 1996-1944
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2025 by the authors.
論文のバージョン publisher
PubMed ID 40363487
DOI 10.3390/ma18091983
Web of Science KeyUT 001486402200001
関連URL isVersionOf https://doi.org/10.3390/ma18091983
タイトル(別表記) The 62nd Annual Meeting of Japan Society of Clinical Oncology
著者 藤原 俊義|
出版物タイトル 岡山医学会雑誌
発行日 2025-04-01
137巻
1号
開始ページ 36
終了ページ 38
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.137.36
言語 日本語
著作権者 Copyright (c) 2025 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.137.36
タイトル(別表記) Questionnaire survey of junior and mid-career otolaryngologists' attitudes towards clinical research
著者 浦口 健介| 頼藤 貴志| 高尾 総司| 菅谷 明子| 安藤 瑞生|
抄録  Introduction : Clinical research is crucial for the advancement of medicine, but modern otolaryngologists' attitudes regarding clinical research have not been known. This study was conducted to survey the background, knowledge, and interest in clinical research among junior and mid-career otolaryngologists.
 Methods : A questionnaire survey was distributed to 34 otolaryngologists with ≤15 years' clinical experience working at Okayama University and its affiliated facilities. The respondents were divided into junior (non-specialists) and mid-career otolaryngologists (specialists) based on whether they were board-certified otolaryngologists. The survey assessed their background, understanding, and interest in clinical research.
 Results : Twenty-nine otolaryngologists (83%) responded (10 junior and 19 mid-career otolaryngologists). There was significant individual variation in their interest and knowledge of clinical research. However, approximately half of the respondents indicated that they were not interested in and/or had never engaged in clinical research.
 Conclusion : The data collected by this survey contribute to our understanding of the current state of clinical research engagement among junior and mid-career otolaryngologists, and they can serve as a basis for exploring future strategies to increase this engagement.
キーワード 臨床研究 (clinical research) 統計解析 (statistical analysis) ビッグデータ (bigdata) 質問紙調査 (questionnaire survey)
出版物タイトル 岡山医学会雑誌
発行日 2025-04-01
137巻
1号
開始ページ 20
終了ページ 24
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.137.20
言語 日本語
著作権者 Copyright (c) 2025 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.137.20
タイトル(別表記) Understanding the pathogenesis of rare monogenic disorders and the social implementation of genomic medicine
著者 武内 俊樹|
キーワード 病態解明 希少遺伝性疾患 社会実装
出版物タイトル 岡山医学会雑誌
発行日 2025-04-01
137巻
1号
開始ページ 10
終了ページ 14
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.137.10
言語 日本語
著作権者 Copyright (c) 2025 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.137.10
フルテキストURL fulltext.pdf
著者 Fukao, Takashi| Fujiwara, Masaki| Yamada, Yuto| Asada, Kazushi| Asada, Takahiro| Ri, Hirotoshi| Sakamoto, Shinji| Takaki, Manabu|
キーワード chronic pain electroconvulsive therapy pain disorder somatic symptom disorder
発行日 2025-04-21
出版物タイトル Psychiatry and Clinical Neurosciences Reports
4巻
2号
出版者 Wiley
開始ページ e70108
ISSN 2769-2558
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2025 The Author(s).
論文のバージョン publisher
PubMed ID 40265150
DOI 10.1002/pcn5.70108
Web of Science KeyUT 001472473500001
関連URL isVersionOf https://doi.org/10.1002/pcn5.70108
フルテキストURL fulltext.pdf
著者 Honda, Manami| Iwamuro, Masaya| Tanaka, Takehiro| Yamasaki, Yasushi| Kawano, Seiji| Hiraoka, Sakiko| Kawahara, Yoshiro| Otsuka, Motoyuki|
キーワード colonoscopy esophagogastroduodenoscopy gastrointestinal neoplasms gastrointestinal stromal tumor neurofibromatosis
発行日 2025-04-16
出版物タイトル JGH Open
9巻
4号
出版者 Wiley
開始ページ e70151
ISSN 2397-9070
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2025 The Author(s).
論文のバージョン publisher
PubMed ID 40247846
DOI 10.1002/jgh3.70151
Web of Science KeyUT 001468535400001
関連URL isVersionOf https://doi.org/10.1002/jgh3.70151
JaLCDOI 10.18926/AMO/68654
フルテキストURL 79_2_139.pdf
著者 Takeda, Yasushige| Noma, Kazuhiro| Maeda, Naoaki| Mizusawa, Yohei| Matsumoto, Hijiri| Kondo, Yuhei| Kunitomo, Tomoyoshi| Tanoue, Yukinori| Hashimoto, Masashi| Tanabe, Shunsuke| Fujiwara, Toshiyoshi|
抄録 In thoracic esophageal cancer, lymph node dissection around the recurrent laryngeal nerve is crucial but poses a risk of nerve palsy, affecting postoperative quality of life. In cases with an aberrant right subclavian artery (ARSA), the right recurrent laryngeal nerve is absent, and the non-recurrent inferior laryngeal nerve (NRILN) enters the larynx directly from the vagus nerve in the cervical region. Identifying the course of the NRILN is vital to avoid injury. A case of esophageal cancer with an ARSA, in which the course of the NRILN was preserved using the Nerve Integrity Monitoring (NIM) system during surgery, is described.
キーワード esophageal cancer intraoperative nerve monitoring aberrant right subclavian artery non-recurrent inferior laryngeal nerve thoracoscopic esophagectomy
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2025-04
79巻
2号
出版者 Okayama University Medical School
開始ページ 139
終了ページ 144
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 40302287
Web of Science KeyUT 001485501900001
JaLCDOI 10.18926/AMO/68653
フルテキストURL 79_2_135.pdf
著者 Fujita, Yasufumi| Shimizu, Shuji| Mohri, Makoto|
抄録 Cardiac calcified amorphous tumor (CAT) is a rare, benign non-neoplastic mass of the heart that is sometimes found due to embolic events. Most cases of CAT are treated with surgical removal to prevent future embolic events. However, the treatment strategy for CAT complicated by atrial fibrillation has remained to be determined. Here we report a case of left ventricular CAT complicated by paroxysmal atrial fibrillation (PAF) that was successfully treated with surgical removal and pulmonary vein isolation. Pulmonary vein isolation can be a simple and effective procedure for PAF, even during surgical removal of CAT.
キーワード calcified amorphous tumor surgical removal embolic stroke paroxysmal atrial fibrillation pulmonary vein isolation
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2025-04
79巻
2号
出版者 Okayama University Medical School
開始ページ 135
終了ページ 138
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 40302286
Web of Science KeyUT 001485501000001
JaLCDOI 10.18926/AMO/68649
フルテキストURL 79_2_109.pdf
著者 Awai, Kyoko| Nakatsuka, Mikiya|
抄録 The status of postpartum depression was elucidated herein with the use of the Edinburgh Postnatal Depression Scale (EPDS) in women in Shikoku, Japan who became pregnant and gave birth after undergoing infertility treatment, including assisted reproductive technology (ART). The assessment was performed during their children’s 4-month health examination. The relationships between postpartum depression and the mothers’ background factors and scores on the Big Five personality traits scale were also examined. Of the Big Five personality traits, the scores for neuroticism were significantly higher in the ART group (n=71) than in the general infertility treatment (n=118) and natural pregnancy (n=872) groups. No significant differences in EPDS scores were seen among these three groups. A logistic regression analysis showed that neuroticism was associated with an EPDS score ≧9 points, (which is suggestive of postpartum depression, ) in all groups. Moreover, although a long-standing marriage had an inhibitory effect on postpartum depression in the natural pregnancy group, no such trend was seen in the ART group, which included many women with long-standing marriages. Particularly for women who become pregnant by ART, an individualized response that pays close attention to the woman’s personality traits is needed.
キーワード infertility treatment assisted reproductive technology postpartum postpartum depression personality trait
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2025-04
79巻
2号
出版者 Okayama University Medical School
開始ページ 109
終了ページ 116
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 40302282
Web of Science KeyUT 001485544200006
JaLCDOI 10.18926/AMO/68648
フルテキストURL 79_2_101.pdf
著者 Isozaki, Hiroshi| Matsumoto, Sasau| Takama, Takehiro| Isozaki, Yuka|
抄録 To evaluate the effectiveness of postoperative irradiation (POI) for patients with cN0 early breast cancer, we retrospectively analyzed the cases of 650 consecutive breast cancer patients who underwent sentinel lymph node (SLN)-guided surgery (2005-2022) at our hospital. In this cohort, 53% (278/521) of the patients who underwent breast conservative surgery (BCS) and 96% (124/129) of those treated with mastectomy did not receive POI. The patients who underwent BCS were treated with POI using opposing tangential field irradiation. A false negative (FN) SLN was retrospectively defined as a negative metastasis in SLN plus positive recurrence in the axillary lymph nodes. Recurrence was detected in 83 patients. A logistic regression analysis revealed that the nuclear grade (odds ratio [OR] 1.69), POI (OR 0.41), and postoperative hormone therapy (OR 0.40) were each significantly related to recurrence. The 26.1% (12/46) FN rate of the non-POI patients decreased to 5.8% (1/17) compared to those treated with POI. The rate of axillary recurrence was significantly lower in the POI group (0.4%) versus the non-POI group (2.7%) (p=0.0355). The rate of locoregional recurrence was also significantly lower in the POI group (2.0%) versus the non-POI group (13.4%) (p<0.0001). No significant difference was observed in the rate of distant recurrence between the POI (4.0%) and non-POI (3.3%) (p=0.831) groups. These results indicated that the postoperative opposing tangential field irradiation of conserved breast tissue inhibited recurrence in the axillary lymph nodes.
キーワード breast cancer postoperative irradiation radiation therapy sentinel lymph nodes recurrence
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2025-04
79巻
2号
出版者 Okayama University Medical School
開始ページ 101
終了ページ 107
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 40302281
Web of Science KeyUT 001485544200005
JaLCDOI 10.18926/AMO/68647
フルテキストURL 79_2_093.pdf
著者 Tsuchie, Rina| Fukuda, Mari| Tsumura, Hideki| Kinuta, Minako| Hisamatsu, Takashi| Kanda, Hideyuki|
抄録 School teachers are subject to both physical and mental health problems. We examined cross-sectional relationships between work engagement and major health outcomes among junior and senior high school teachers in Japan via a nationwide survey in 2019-2020. A total of 3,160 respondents were included in the analyses (19.9% response rate). Work engagement was assessed with the Utrecht Work Engagement Scale-9 (UWES-9), and we thus divided the teachers into quartiles according to their UWES-9 scores. Based on validated questionnaires, we assessed insomnia, psychological distress, and neck pain as health outcomes. A binomial logistic regression adjusted for age, gender, school type, teacher’s roles, involvement in club activities, division of duties, employment status, and whether they lived with family demonstrated that the teachers with lower UWES-9 scores had higher burdens of insomnia, psychological distress, and neck pain (odds ratios [95% confidence intervals] in 4th vs. 1st quartile, 2.92 (2.34-3.65), 3.70 (2.81-4.88), and 2.12 (1.68-2.68), respectively; all trend p<0.001). There were no significant differences in these associations between full-time and part-time teachers. Our findings indicate that low work engagement may contribute to physical and mental health issues among junior and senior high school teachers, thus providing insights for preventing health problems in this profession.
キーワード work engagement school teachers insomnia psychological distress neck pain
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2025-04
79巻
2号
出版者 Okayama University Medical School
開始ページ 93
終了ページ 100
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 40302280
Web of Science KeyUT 001485544200004
JaLCDOI 10.18926/AMO/68644
フルテキストURL 79_2_065.pdf
著者 Maki, Masatoshi| Takada, Ryo| Ishigo, Tomoyuki| Fujiwara, Miki| Takahashi, Yoko| Otsuka, Shinya| Tamura, Koji| Hamaoka, Terutaka|
抄録 Anamorelin (ANAM) is used to treat cancer-associated cachexia, a syndrome involving muscle loss and anorexia. The timing of the initiation of ANAM treatment is crucial to its efficacy. Although the body mass index (BMI) is a diagnostic criterion for cancer cachexia, no studies have explored its association with ANAM efficacy. We conducted a single-center, retrospective cohort study to investigate the association between the pre-treatment BMI and ANAM efficacy in patients with cancer-associated cachexia (n=47). The ANAM treatment was considered effective if the patient’s appetite improved within 30 days of treatment initiation. We calculated a BMI cutoff value (19.5 kg/m2) and used it to divide the patients into high- and low-BMI groups. Their background, clinical laboratory values, cancer types, and treatment lines were investigated. Twenty (42.6%) had a high BMI (≥ 19.5 kg/m2) and 27 (57.4%) had a low BMI (< 19.5 kg/m2). High BMI was significantly associated with ANAM effectiveness (odds ratio 7.86, 95% confidence interval 1.99-31.00, p=0.003). Together these results indicate that it is beneficial to initiate ANAM treatment before a patient’s BMI drops below 19.5 kg/m2. Our findings will help advance cancer cachexia treatment and serve as a reference for clinicians to predict ANAM’s efficacy.
キーワード anamorelin cancer-associated cachexia body mass index albumin efficacy rate
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2025-04
79巻
2号
出版者 Okayama University Medical School
開始ページ 65
終了ページ 73
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 40302277
Web of Science KeyUT 001485544200001
フルテキストURL fulltext.pdf
著者 Yamaguchi, Saki| Ishikawa, Kazuya| Furuta, Kazuyuki| Kaito, Chikara|
キーワード wzxE flippase enterobacterial common antigen low pH low temperature hyperosmotic stress
発行日 2025-04-10
出版物タイトル Applied and Environmental Microbiology
出版者 American Society for Microbiology
ISSN 0099-2240
NCID AA00543249
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2025 Yamaguchi et al.
論文のバージョン publisher
PubMed ID 40207904
DOI 10.1128/aem.02595-24
Web of Science KeyUT 001462873400001
関連URL isVersionOf https://doi.org/10.1128/aem.02595-24
フルテキストURL interdisciplinary_5_contents_e.pdf
出版物タイトル 統合科学
発行日 2025-03-31
5巻
ISSN 2436-3227
言語 日本語
論文のバージョン publisher
フルテキストURL fulltext.pdf
著者 Tamura, Masanori| Furumatsu, Takayuki| Kitayama, Takahiro| Yokoyama, Yusuke| Okazaki, Yuki| Kawada, Koki| Ozaki, Toshifumi|
キーワード Medial meniscus Posterior root tear Distance Pullout repair Second-look arthroscopy
発行日 2025-04-03
出版物タイトル Knee Surgery & Related Research
37巻
1号
出版者 Springer Nature
開始ページ 16
ISSN 2234-2451
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2025.
論文のバージョン publisher
PubMed ID 40181486
DOI 10.1186/s43019-025-00264-7
Web of Science KeyUT 001459123500001
関連URL isVersionOf https://doi.org/10.1186/s43019-025-00264-7
フルテキストURL fulltext.pdf
著者 Al-Hammad, Wlla E.| Kuroda, Masahiro| Al Jamal, Jamal, Ghaida| Fujikura, Mamiko| Kamizaki, Ryo| Kuroda, Kazuhiro| Yoshida, Suzuka| Nakamura, Yoshihide| Oita, Masataka| Tanabe, Yoshinori| Sugimoto, Kohei| Sugianto, Irfan| Barham, Majd| Tekiki, Nouha| Hisatomi, Miki| Asaumi, Junichi|
キーワード breast cancer radiation therapy heart dose cut-off value machine learning robustness instability F2 score deep inspiration breath-hold technique computed tomography
発行日 2025-03-10
出版物タイトル Diagnostics
15巻
6号
出版者 MDPI
開始ページ 668
ISSN 2075-4418
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2025 by the authors.
論文のバージョン publisher
PubMed ID 40150011
DOI 10.3390/diagnostics15060668
Web of Science KeyUT 001452220400001
関連URL isVersionOf https://doi.org/10.3390/diagnostics15060668
フルテキストURL fulltext.pdf
著者 Miyai, Hisataka| Tomofuji, Takaaki| Mizuno, Hirofumi| Morita, Manabu| Nakahara, Momoko| Kataoka, Kota| Sumita, Ichiro| Uchida, Yurika| Toyama, Naoki| Yokoi, Aya| Yamanaka-Kohno, Reiko| Takeuchi, Noriko| Maruyama, Takayuki| Ekuni, Daisuke|
キーワード halitosis trehalose oral dryness cross-over study randomized trial
発行日 2025-03-13
出版物タイトル Healthcare
13巻
6号
出版者 MDPI
開始ページ 619
ISSN 2227-9032
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2025 by the authors.
論文のバージョン publisher
PubMed ID 40150469
DOI 10.3390/healthcare13060619
Web of Science KeyUT 001452703300001
関連URL isVersionOf https://doi.org/10.3390/healthcare13060619
タイトル(別表記) Summary of Research Activities : Okayama Administrative Law Research Group
フルテキストURL orl_026_143_144.pdf
出版物タイトル 臨床法務研究
発行日 2025-03
26巻
開始ページ 143
終了ページ 144
ISSN 1881-1485
言語 日本語
論文のバージョン publisher
JaLCDOI 10.18926/bgeou/68560
タイトル(別表記) Student Evaluation of a Revised Course of Sociology Lectures in the Liberal-arts Education
フルテキストURL bgeou_109_115_130.pdf
著者 野邊 政雄|
抄録  私は平成10年度の前期に一般科目(一般教養科目)の「社会学」の授業を担当した。本稿では,受講学生の授業評価などにより,その授業を検討し,次の3点を明らかにした。(1)私は,映画やドキュメンタリーを上映したり「講義ノート」を配布することで,社会学の授業を理解しやすくするように努めた。また,書評レポートを学生に書かせ論文作成の基礎を学ばせようとした。学生は,これらの授業改善をかなり評価していた。それから,授業のやり方や講義内容でとりたてて問題点はなかった。(2)多くの学生は,映画を上映したとき,授業時間が延長になることに苦情を持っていた。私は学生があげた苦情を解決しようと授業中に努力したが,大部分の苦情は私の努力ではどうにもできないものであった。(3)大学の当局や事務担当者には,次の2つが望まれる。第1に, 2時限連続の授業を設けることができるようにするなど,授業の性格に応じてより柔軟に,授業を開講できるようすべきだ。もしこれが可能であれば,私の授業に対する学生の苦情はほとんどなかった。第2に,シラバスを全学部の学生に配布するとか,インターネットで誰でも簡単に閲覧できるようにすべきだ。
 次に,授業の改善として,私は次の3点を提案した。(1)研究の方法を一般教育課程で学生に組織的に教えること。(2)大学の授業を他の教官に公開することによって,授業の改善に努めること。(3)教官の授業負担を軽減し,授業の充実をはかること。
キーワード 社会学 授業改善 授業評価
出版物タイトル 岡山大学教育学部研究集録
発行日 1998-11-13
109巻
開始ページ 115
終了ページ 130
ISSN 0471-4008
言語 日本語
論文のバージョン publisher