start-ver=1.4 cd-journal=joma no-vol=4 cd-vols= no-issue= article-no= start-page=287 end-page=293 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=FURUMATSU Takashi Multipolarity in eastern Eurasia kn-title=古松崇志著『ユーラシア東方の多極共存時代』 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WATANABEKenya en-aut-sei=WATANABE en-aut-mei=Kenya kn-aut-name=渡辺健哉 kn-aut-sei=渡辺 kn-aut-mei=健哉 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=大阪公立大学 END start-ver=1.4 cd-journal=joma no-vol=136 cd-vols= no-issue=3 article-no= start-page=91 end-page=93 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20241202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 2023 Incentive Award of the Okayama Medical Association in General Medical Science (2023 Yuuki Prize) kn-title=令和５年度岡山医学会賞　総合研究奨励賞（結城賞） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeHaruki en-aut-sei=Watanabe en-aut-mei=Haruki kn-aut-name=渡辺晴樹 kn-aut-sei=渡辺 kn-aut-mei=晴樹 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝学 END start-ver=1.4 cd-journal=joma no-vol=3 cd-vols= no-issue= article-no= start-page=308 end-page=314 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=WATANABE Shinichiro The study of ancient Chinese state kn-title=渡辺信一郎著『中国古代国家論』 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TSUCHIGUCHIFuminori en-aut-sei=TSUCHIGUCHI en-aut-mei=Fuminori kn-aut-name=土口史記 kn-aut-sei=土口 kn-aut-mei=史記 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=17 cd-vols= no-issue=6 article-no= start-page=e0270569 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Real-world data on vitamin D supplementation and its impacts in systemic lupus erythematosus: Cross-sectional analysis of a lupus registry of nationwide institutions (LUNA) en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background Although vitamin D concentration is reportedly associated with the pathogenesis and pathology of systemic lupus erythematosus (SLE), benefits of vitamin D supplementation in SLE patients have not been elucidated, to our knowledge. We investigated the clinical impacts of vitamin D supplementation in SLE. Methods A cross-sectional analysis was performed using data from a lupus registry of nationwide institutions. We evaluated vitamin D supplementation status associated with diseaserelated Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) as a parameter of long-term disease activity control. Results Of the enrolled 870 patients (mean age: 45 years, mean disease duration: 153 months), 426 (49%) received vitamin D supplementation. Patients with vitamin D supplementation were younger (43.2 vs 47.5 years, P < 0.0001), received higher doses of prednisolone (7.6 vs 6.8 mg/day, P= 0.002), and showed higher estimated glomerular filtration rates (79.3 vs 75.3 mL/min/1.73m(2), P= 0.02) than those without supplementation. Disease-related SDI (0.73 +/- 1.12 vs 0.73 +/- 1.10, P = 0.75), total SDI, and SLE Disease Activity Index (SLEDAI) did not significantly differ between patients receiving and not receiving vitamin D supplementation. Even after excluding 136 patients who were highly recommended vitamin D supplementation (with age >= 75 years, history of bone fracture or avascular necrosis, denosumab use, and end-stage renal failure), disease-related SDI, total SDI, and SLEDAI did not significantly differ between the two groups. Conclusions Even with a possible Vitamin D deficiency and a high risk of bone fractures in SLE patients, only half of our cohort received its supplementation. The effect of vitamin D supplementation for disease activity control was not observed. en-copyright= kn-copyright= en-aut-name=HayashiKeigo en-aut-sei=Hayashi en-aut-mei=Keigo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SadaKen-Ei en-aut-sei=Sada en-aut-mei=Ken-Ei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AsanoYosuke en-aut-sei=Asano en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KatayamaYu en-aut-sei=Katayama en-aut-mei=Yu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OhashiKeiji en-aut-sei=Ohashi en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MorishitaMichiko en-aut-sei=Morishita en-aut-mei=Michiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MiyawakiYoshia en-aut-sei=Miyawaki en-aut-mei=Yoshia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=WatanabeHaruki en-aut-sei=Watanabe en-aut-mei=Haruki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KatsuyamaTakayuki en-aut-sei=Katsuyama en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NarazakiMariko en-aut-sei=Narazaki en-aut-mei=Mariko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MatsumotoYoshinori en-aut-sei=Matsumoto en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YajimaNobuyuki en-aut-sei=Yajima en-aut-mei=Nobuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=YoshimiRyusuke en-aut-sei=Yoshimi en-aut-mei=Ryusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=ShimojimaYasuhiro en-aut-sei=Shimojima en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=OhnoShigeru en-aut-sei=Ohno en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=KajiyamaHiroshi en-aut-sei=Kajiyama en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=IchinoseKunihiro en-aut-sei=Ichinose en-aut-mei=Kunihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=SatoShuzo en-aut-sei=Sato en-aut-mei=Shuzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=FujiwaraMichio en-aut-sei=Fujiwara en-aut-mei=Michio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Medicine, Division of Rheumatology, Showa University School of Medicine kn-affil= affil-num=13 en-affil=Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine kn-affil= affil-num=14 en-affil=Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine kn-affil= affil-num=15 en-affil=Center for Rheumatic Diseases, Yokohama City University Medical Center kn-affil= affil-num=16 en-affil=Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University kn-affil= affil-num=17 en-affil=Department of Immunology and Rheumatology, Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences kn-affil= affil-num=18 en-affil=Department of Rheumatology, Fukushima Medical University School of Medicine kn-affil= affil-num=19 en-affil=Department of Rheumatology, Yokohama Rosai Hospital kn-affil= affil-num=20 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=7 article-no= start-page=1055 end-page=1060 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Acute Kidney Injury Caused by Evans Syndrome with Systemic Lupus Erythematosus and Systemic Sclerosis en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 65-year-old woman with systemic sclerosis and systemic lupus erythematosus developed acute kidney injury (AKI), Coombs-positive autoimmune hemolytic anemia and autoimmune thrombocytopenia; therefore, she was diagnosed with Evans syndrome (ES). Intravascular hemolysis was suggested as the cause of AKI based on the presence of acute tubular injury and trace hemosiderin deposits on the renal biopsy. The renal function, hemolytic anemia and thrombocytopenia were restored by an increased dose of glucocorticoids, hemodialysis, and plasma exchange. Although ES with severe hemolytic anemia is very rare, it is important to detect possible renal dysfunction when encountering patients with severe hemolysis. en-copyright= kn-copyright= en-aut-name=MatsuokaNatsumi en-aut-sei=Matsuoka en-aut-mei=Natsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WatanabeHaruki en-aut-sei=Watanabe en-aut-mei=Haruki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KurookaNaoko en-aut-sei=Kurooka en-aut-mei=Naoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KatoSumari en-aut-sei=Kato en-aut-mei=Sumari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HigashiChika en-aut-sei=Higashi en-aut-mei=Chika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TanabeKatsuyuki en-aut-sei=Tanabe en-aut-mei=Katsuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KinomuraMasaru en-aut-sei=Kinomura en-aut-mei=Masaru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=FujiiNobuharu en-aut-sei=Fujii en-aut-mei=Nobuharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SadaKen-Ei en-aut-sei=Sada en-aut-mei=Ken-Ei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=SugiyamaHitoshi en-aut-sei=Sugiyama en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Division of Hemodialysis and Apheresis, Okayama University Hospital kn-affil= affil-num=7 en-affil=Division of Hemodialysis and Apheresis, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Transfusion Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Human Resource Development of Dialysis Therapy for Kidney Disease, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=acute kidney injury kn-keyword=acute kidney injury en-keyword=Evans syndrome kn-keyword=Evans syndrome en-keyword=autoimmune hemolytic anemia kn-keyword=autoimmune hemolytic anemia END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue=1 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210304 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Exploratory classification of clinical phenotypes in Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis using cluster analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=A novel patient cluster in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) may be identified in Japan. We performed multiple correspondence and cluster analysis regarding 427 clinically diagnosed AAV patients excluding eosinophilic granulomatosis with polyangiitis. Model 1 included the ANCA phenotype, items of the Birmingham Vasculitis Activity Score, and interstitial lung disease; model 2 included serum creatinine (s-Cr) and C-reactive protein (CRP) levels with model 1 components. In seven clusters determined in model 1, the ANCA-negative (n=8) and proteinase 3-ANCA-positive (n=41) groups emerged as two distinct clusters. The other five myeloperoxidase-ANCA-positive clusters were characterized by ear, nose, and throat (ENT) (n=47); cutaneous (n=36); renal (n=256), non-renal (n=33); and both ENT and cutaneous symptoms (n=6). Four clusters in model 2 were characterized by myeloperoxidase-ANCA negativity (n=42), without s-Cr elevation (<1.3 mg/dL) (n=157), s-Cr elevation (1.3 mg/dL) with high CRP (>10 mg/dL) (n=71), or s-Cr elevation (>= 1.3 mg/dL) without high CRP (<= 10 mg/dL) (n=157). Overall, renal, and relapse-free survival rates were significantly different across the four clusters in model 2. ENT, cutaneous, and renal symptoms may be useful in characterization of Japanese AAV patients with myeloperoxidase-ANCA. The combination of s-Cr and CRP levels may be predictive of prognosis. en-copyright= kn-copyright= en-aut-name=WatanabeHaruki en-aut-sei=Watanabe en-aut-mei=Haruki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SadaKen-ei en-aut-sei=Sada en-aut-mei=Ken-ei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HarigaiMasayoshi en-aut-sei=Harigai en-aut-mei=Masayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AmanoKoichi en-aut-sei=Amano en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=DobashiHiroaki en-aut-sei=Dobashi en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakasakiYoshinari en-aut-sei=Takasaki en-aut-mei=Yoshinari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=FujimotoShouichi en-aut-sei=Fujimoto en-aut-mei=Shouichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=AtsumiTatsuya en-aut-sei=Atsumi en-aut-mei=Tatsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamagataKunihiro en-aut-sei=Yamagata en-aut-mei=Kunihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HommaSakae en-aut-sei=Homma en-aut-mei=Sakae kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=ArimuraYoshihiro en-aut-sei=Arimura en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=Research Committee of Intractable Vasculitis Syndrome (JPVAS) & Research Committee of Intractable Renal Disease of the Ministry of Health, Labour, and Welfare of Japan en-aut-sei=Research Committee of Intractable Vasculitis Syndrome (JPVAS) & Research Committee of Intractable Renal Disease of the Ministry of Health, Labour, and Welfare of Japan en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Rheumatology, Tokyo Women’s Medical University School of Medicine kn-affil= affil-num=4 en-affil=Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University kn-affil= affil-num=5 en-affil=Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University kn-affil= affil-num=6 en-affil=Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine kn-affil= affil-num=7 en-affil=Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki kn-affil= affil-num=8 en-affil=Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University kn-affil= affil-num=9 en-affil=Department of Nephrology, Faculty of Medicine, University of Tsukuba kn-affil= affil-num=10 en-affil=Department of Advanced and Integrated Interstitial Lung Diseases Research, School of Medicine, Toho University kn-affil= affil-num=11 en-affil=Department of Nephrology and Rheumatology, Kyorin University School of Medicine kn-affil= affil-num=12 en-affil=Okayama University kn-affil= affil-num=13 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=1 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Association of glucocorticoid doses and emotional health in lupus low disease activity state (LLDAS): a cross-sectional study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background While survival of systemic lupus erythematosus (SLE) patients has improved substantially, problems remain in the management of their emotional health. Medium to high-dose glucocorticoid doses are known to worsen emotional health; the effect is unclear among patients receiving relatively low-dose glucocorticoids. This study aims to investigate the association between low glucocorticoid doses and emotional health in lupus low disease activity state (LLDAS). Methods This cross-sectional study drew on data from SLE patients in 10 Japanese institutions. The participants were adult patients with SLE duration of >= 1 year who met LLDAS criteria at the study visit from April 2018 through September 2019. The exposure was the daily glucocorticoid dose (mg oral prednisolone). The outcome was the emotional health score of the lupus patient-reported outcome scale (range: 0 to 100). Multiple linear regression analysis was performed with adjustment for confounders including disease-related damage, activity, and psychotropic drug use. Results Of 192 patients enrolled, 175 were included in the analysis. Their characteristics were as follows: female, 89.7%; median age, 47 years (interquartile range (IQR): 37.0, 61.0). Median glucocorticoid dose was 4.0 mg (IQR 2.0, 5.0), and median emotional health score 79.2 (IQR 58.3, 91.7). Multiple linear regression analysis showed daily glucocorticoid doses to be associated with worse emotional health (beta coefficient = - 2.54 [95% confidence interval - 4.48 to - 0.60], P = 0.01). Conclusions Daily glucocorticoid doses were inversely associated with emotional health among SLE patients in LLDAS. Further studies are needed to determine whether glucocorticoid tapering leads to clinically significant improvements in emotional health. en-copyright= kn-copyright= en-aut-name=MiyawakiYoshia en-aut-sei=Miyawaki en-aut-mei=Yoshia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShimizuSayaka en-aut-sei=Shimizu en-aut-mei=Sayaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OgawaYusuke en-aut-sei=Ogawa en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SadaKen-Ei en-aut-sei=Sada en-aut-mei=Ken-Ei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KatayamaYukitoshi en-aut-sei=Katayama en-aut-mei=Yukitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AsanoYosuke en-aut-sei=Asano en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HayashiKeigo en-aut-sei=Hayashi en-aut-mei=Keigo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamamuraYuriko en-aut-sei=Yamamura en-aut-mei=Yuriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=Hiramatsu-AsanoSumie en-aut-sei=Hiramatsu-Asano en-aut-mei=Sumie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OhashiKeiji en-aut-sei=Ohashi en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MorishitaMichiko en-aut-sei=Morishita en-aut-mei=Michiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=WatanabeHaruki en-aut-sei=Watanabe en-aut-mei=Haruki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=Takano-NarazakiMariko en-aut-sei=Takano-Narazaki en-aut-mei=Mariko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=MatsumotoYoshinori en-aut-sei=Matsumoto en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=YajimaNobuyuki en-aut-sei=Yajima en-aut-mei=Nobuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=YoshimiRyusuke en-aut-sei=Yoshimi en-aut-mei=Ryusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=ShimojimaYasuhiro en-aut-sei=Shimojima en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=OhnoShigeru en-aut-sei=Ohno en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=KajiyamaHiroshi en-aut-sei=Kajiyama en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=IchinoseKunihiro en-aut-sei=Ichinose en-aut-mei=Kunihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=SatoShuzo en-aut-sei=Sato en-aut-mei=Shuzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=FujiwaraMichio en-aut-sei=Fujiwara en-aut-mei=Michio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= en-aut-name=YamazakiHajime en-aut-sei=Yamazaki en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=23 ORCID= en-aut-name=YamamotoYosuke en-aut-sei=Yamamoto en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=24 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=25 ORCID= en-aut-name=FukuharaShunichi en-aut-sei=Fukuhara en-aut-mei=Shunichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=26 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Institute for Health Outcome & Process Evaluation Research (i-Hope International) kn-affil= affil-num=3 en-affil=Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University kn-affil= affil-num=4 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Ushimado Marine Institute, Faculty of Science, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=13 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=14 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=15 en-affil=Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University kn-affil= affil-num=16 en-affil=Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine kn-affil= affil-num=17 en-affil=Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine kn-affil= affil-num=18 en-affil=Center for Rheumatic Diseases, Yokohama City University Medical Center kn-affil= affil-num=19 en-affil=Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University kn-affil= affil-num=20 en-affil=Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences kn-affil= affil-num=21 en-affil=Department of Rheumatology, Fukushima Medical University School of Medicine kn-affil= affil-num=22 en-affil=Department of Rheumatology, Yokohama Rosai Hospital kn-affil= affil-num=23 en-affil=Section of Clinical Epidemiology, Department of Community Medicine, Graduate School of Medicine, Kyoto University kn-affil= affil-num=24 en-affil=Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University kn-affil= affil-num=25 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=26 en-affil=Section of Clinical Epidemiology, Department of Community Medicine, Graduate School of Medicine, Kyoto University kn-affil= en-keyword=Systemic lupus erythematosus kn-keyword=Systemic lupus erythematosus en-keyword=Glucocorticoid kn-keyword=Glucocorticoid en-keyword=Emotional health kn-keyword=Emotional health en-keyword=Patient-reported outcome kn-keyword=Patient-reported outcome en-keyword=Depression kn-keyword=Depression en-keyword=Anxiety kn-keyword=Anxiety en-keyword=Cross-sectional study kn-keyword=Cross-sectional study END start-ver=1.4 cd-journal=joma no-vol=100 cd-vols= no-issue=3 article-no= start-page=e24028 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210122 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Granulomatosis with polyangiitis with obstructive pneumonia progressing to hypertrophic pachymeningitis A case report en-subtitle= kn-subtitle= en-abstract= kn-abstract=Rationale:
Bronchial involvement alone is a rare initial manifestation of granulomatosis with polyangiitis (GPA). Herein, we report a case of refractory GPA with obstructive pneumonia caused by bronchial involvement.
Patient concerns:
A 65-year-old man complained of a 2-week cough and fever.
Diagnoses:
Considering the presence of opacities and multiple consolidations in both lungs due to obstruction or stenosis on the bronchus, which did not respond to antibiotics, and proteinase-3-antineutrophil cytoplasmic autoantibody positivity, he was diagnosed with GPA. Positron emission tomography- computed tomography scan revealed no abnormal findings in the upper respiratory tract.
Interventions:
He was treated with prednisolone (PSL, 50 mg/d) and intravenous cyclophosphamide.
Outcomes:
His general and respiratory symptoms improved. However, 8 weeks after PSL treatment at 20 mg/d, he developed a relapse of vasculitis along with sinusitis and hypertrophic pachymeningitis. Hence, PSL treatment was resumed to 50 mg/d, and weekly administration of rituximab was initiated. Consequently, the symptoms gradually mitigated.
Lessons:
GPA with bronchial involvement is often intractable and requires careful follow-up, which should include upper respiratory tract and hypertrophic pachymeningitis assessment. en-copyright= kn-copyright= en-aut-name=HayashiKeigo en-aut-sei=Hayashi en-aut-mei=Keigo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WatanabeHaruki en-aut-sei=Watanabe en-aut-mei=Haruki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamamuraYuriko en-aut-sei=Yamamura en-aut-mei=Yuriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AsanoYosuke en-aut-sei=Asano en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KatayamaYukitoshi en-aut-sei=Katayama en-aut-mei=Yukitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=Hiramatsu-AsanoSumie en-aut-sei=Hiramatsu-Asano en-aut-mei=Sumie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OhashiKeiji en-aut-sei=Ohashi en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MorishitaMichiko en-aut-sei=Morishita en-aut-mei=Michiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NarazakiMariko en-aut-sei=Narazaki en-aut-mei=Mariko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MatsumotoYoshinori en-aut-sei=Matsumoto en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=SadaKen-Ei en-aut-sei=Sada en-aut-mei=Ken-Ei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=bronchial stenosis kn-keyword=bronchial stenosis en-keyword=granulomatosis with polyangiitis kn-keyword=granulomatosis with polyangiitis en-keyword=hypertrophic pachymeningitis kn-keyword=hypertrophic pachymeningitis en-keyword=rituximab kn-keyword=rituximab END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=1 article-no= start-page=95 end-page=101 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202102 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Minimally Invasive Spinal Stabilization with Denosumab before Total Spondylectomy for a Collapsing Lower Lumbar Spinal Giant Cell Tumor en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 21-year-old man consulted our hospital for treatment of a spinal giant cell tumor (GCT) of Enneking stage III. Lower lumbar-spine tumors and severe spinal canal stenosis are associated with high risk for surgical mor-bidity. Stability was temporarily secured with a percutaneous pedicle screw fixation in combination with deno-sumab, which shrank the tumor. Total en bloc spondylectomy was then performed 6 months after initiation of denosumab, and the patient was followed for 3 years. There was no local recurrence, and bony fusion was obtained. Minimally invasive surgery and denosumab allowed safer and easier treatment of a collapsing lower lumbar extra-compartmental GCT. en-copyright= kn-copyright= en-aut-name=MinatoKeitaro en-aut-sei=Minato en-aut-mei=Keitaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HiranoToru en-aut-sei=Hirano en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KawashimaHiroyuki en-aut-sei=Kawashima en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamagishiTetsuro en-aut-sei=Yamagishi en-aut-mei=Tetsuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=WatanabeKeigo en-aut-sei=Watanabe en-aut-mei=Keigo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OhashiMasayuki en-aut-sei=Ohashi en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OgoseAkira en-aut-sei=Ogose en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=EndoNaoto en-aut-sei=Endo en-aut-mei=Naoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=2 en-affil=Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=3 en-affil=Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=4 en-affil=Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=5 en-affil=Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=6 en-affil=Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=7 en-affil=Department of Orthopedic Surgery, Uonuma Kikan Hospital kn-affil= affil-num=8 en-affil=Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= en-keyword=spinal stabilization kn-keyword=spinal stabilization en-keyword=denosumab kn-keyword=denosumab en-keyword=spondylectomy kn-keyword=spondylectomy en-keyword=giant cell tumor kn-keyword=giant cell tumor END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue=1 article-no= start-page=18715 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20201030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Risk of higher dose methotrexate for renal impairment in patients with rheumatoid arthritis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Renal impairment is a major concern in patients taking high-dose methotrexate (MTX) for malignancy, but it has not been fully explored in rheumatoid arthritis (RA) patients taking low-dose MTX. This study aimed to elucidate the dose-dependent effects of MTX on the renal function of patients with RA. We retrospectively reviewed 502 consecutive RA patients who were prescribed MTX for >= 1 year at Okayama University Hospital between 2006 and 2018. The primary outcome was the change in estimated glomerular filtration rate (eGFR) over 1 year. The association between MTX dosage (<8, 8-12, and >= 12 mg/week) and the change in eGFR was evaluated using multiple linear regression analysis with adjustment for possible confounding factors including age, sex, disease duration, body weight, comorbidity, baseline eGFR, concomitant treatment, and disease activity. Mean patient age was 63 years; 394 (78%) were female. Median disease duration was 77 months, while mean MTX dosage was 8.6 mg/week. The last 1-year change of eGFR (mean +/- SD) in patients treated with MTX<8 (n=186), 8-12 (n=219),>= 12 mg/week (n=97) decreased by 0.2 +/- 7.3, 0.6 +/- 8.6, and 4.5 +/- 7.9 mL/min/1.73 m(2)/year, respectively (p<0.0001). After adjustment for the confounding factors, MTX >= 12 mg/week was still correlated with a decrease in 1-year eGFR (beta-coefficient:-2.5; 95% confidence interval,-4.3 to-0.6; p=0.0089) in contrast to MTX 8-12 mg/week. Careful monitoring of renal function is required in patients with MTX >= 12 mg/week over the course of RA treatment regardless of disease duration. en-copyright= kn-copyright= en-aut-name=HayashiKeigo en-aut-sei=Hayashi en-aut-mei=Keigo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SadaKen-Ei en-aut-sei=Sada en-aut-mei=Ken-Ei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AsanoYosuke en-aut-sei=Asano en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name= Hiramatsu AsanoSumie en-aut-sei= Hiramatsu Asano en-aut-mei=Sumie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamamuraYuriko en-aut-sei=Yamamura en-aut-mei=Yuriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OhashiKeiji en-aut-sei=Ohashi en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MorishitaMichiko en-aut-sei=Morishita en-aut-mei=Michiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=WatanabeHaruki en-aut-sei=Watanabe en-aut-mei=Haruki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NarazakiMariko en-aut-sei=Narazaki en-aut-mei=Mariko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MatsumotoYoshinori en-aut-sei=Matsumoto en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Nephrology kn-keyword=Nephrology en-keyword=Rheumatology kn-keyword=Rheumatology END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=14 article-no= start-page=1 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=譬喩の要因――万葉集第八・一五〇〇番歌について―― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺護 kn-aut-sei=渡辺 kn-aut-mei=護 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学文学部 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=19 article-no= start-page=8 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=19910331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=万葉集の一回的素材 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺護 kn-aut-sei=渡辺 kn-aut-mei=護 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学文学部 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=23 article-no= start-page=13 end-page=22 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=19950331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=紫式部３２－３５番歌についての考察――「文散らし」をめぐって―― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺健 kn-aut-sei=渡辺 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学文学研究科修士課程 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=30 article-no= start-page=82 end-page=91 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=後鳥羽院の『遠島御歌合』「忍恋」題歌について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺健 kn-aut-sei=渡辺 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院文化科学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=35 article-no= start-page=24 end-page=35 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=後鳥羽院『千五百番歌合』判歌の最終歌について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺健 kn-aut-sei=渡辺 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=関西高校 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=38 article-no= start-page=28 end-page=41 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=後鳥羽院の『千五百番歌合』百首歌について―同時代歌人からの影響を中心に― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺健 kn-aut-sei=渡辺 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=関西高校 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=39 article-no= start-page=70 end-page=82 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=後鳥羽院の『千五百番歌合』百首歌について　続考―同時代歌人からの摂取の意図― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺健 kn-aut-sei=渡辺 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=関西高校 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=41 article-no= start-page=1 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=後鳥羽院の『千五百番歌合』秋二・秋三判歌について　補遺―その制作時期・意図と建久期速詠歌からの影響― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺健 kn-aut-sei=渡辺 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=関西高校 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=42 article-no= start-page=15 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=後鳥羽院の『千五百番歌合』秋二・秋三判歌について―その秀句志向と藤原定家からの影響― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺健 kn-aut-sei=渡辺 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=関西高校 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=43 article-no= start-page=1 end-page=17 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=『時代不同歌合』の歌人の選定について―その歌人的評価から― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺健 kn-aut-sei=渡辺 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=関西高校 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=45 article-no= start-page=38 end-page=50 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=門脇重綾と和歌――その長歌の表現の特質―― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺健 kn-aut-sei=渡辺 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=米子工業高等専門学校 END start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue=1 article-no= start-page=208 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Association of explanatory histological findings and urinary protein and serum creatinine levels at renal biopsy in lupus nephritis: a cross-sectional study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background
The aim of the present study was to evaluate the association between the histology of active and chronic lesions and urinary protein and serum creatinine (SCr) levels, as common clinical endpoints in clinical trials for lupus nephritis (LN).
Methods
In total, 119 patients diagnosed with LN class III, IV, and V, as defined by the International Society of Nephrology/Renal Pathology Society, between 1990 and 2015, were enrolled in the present study. Multiple regression analysis was performed to explore semi-quantitative histological variables associated with urinary protein and SCr levels.
Results
The mean age of the enrolled patients was 45 years, and 79% were female. The mean SCr and mean urinary protein levels at the time of renal biopsy were 0.87 mg/dl and 3.00 g/gCr, respectively. Class IV (71%) was the most common type of LN followed by class III (17%), and class V (13%). Multicollinearity was confirmed between monocellular infiltration (variance inflation factor [VIF] = 10.22) and interstitial fibrosis (VIF = 10.29), and between karyorrhexis (VIF = 4.14) and fibrinoid necrosis (VIF = 4.29). Fibrinoid necrosis and monocellular infiltration were subsequently excluded, and multiple regression analysis revealed that only the urinary protein level was correlated with wire loop lesions (β-coefficient [β]: 1.09 and confidence interval [CI]: 0.35 to 1.83), and that the SCr level was correlated with glomerular sclerosis (β: 1.08 and CI: 0.43 to 1.74).
Conclusion
As urinary protein and SCr levels were not quantitatively associated with active lesions, they may not accurately reflect the response to remission induction therapy in patients with LN. en-copyright= kn-copyright= en-aut-name=KatsuyamaEri en-aut-sei=Katsuyama en-aut-mei=Eri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyawakiYoshia en-aut-sei=Miyawaki en-aut-mei=Yoshia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SadaKen-Ei en-aut-sei=Sada en-aut-mei=Ken-Ei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AsanoYosuke en-aut-sei=Asano en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HayashiKeigo en-aut-sei=Hayashi en-aut-mei=Keigo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamamuraYuriko en-aut-sei=Yamamura en-aut-mei=Yuriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=Hiramatsu-AsanoSumie en-aut-sei=Hiramatsu-Asano en-aut-mei=Sumie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MorishitaMichiko en-aut-sei=Morishita en-aut-mei=Michiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OhashiKeiji en-aut-sei=Ohashi en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=WatanabeHaruki en-aut-sei=Watanabe en-aut-mei=Haruki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KatsuyamaTakayuki en-aut-sei=Katsuyama en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NarazakiMariko en-aut-sei=Narazaki en-aut-mei=Mariko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=MatsumotoYoshinori en-aut-sei=Matsumoto en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=13 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=14 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Lupus nephritis kn-keyword=Lupus nephritis en-keyword=Active lesions kn-keyword=Active lesions en-keyword=Chronic lesions kn-keyword=Chronic lesions en-keyword=Urinary protein kn-keyword=Urinary protein en-keyword=Serum creatinine kn-keyword=Serum creatinine END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=3 article-no= start-page=191 end-page=198 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202006 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Risk Factors for Chronic Damage Accumulation Across Different Onset Eras in Systemic Lupus Erythematosus: A Cross-sectional Analysis of a Lupus Registry of Nationwide Institutions (LUNA) en-subtitle= kn-subtitle= en-abstract= kn-abstract=Chronic damage accumulation affects not only mortality but also quality of life in patients with systemic lupus erythematosus (SLE). Risk factors for chronic damage were explored in SLE through different onset eras. Two hundred forty-five patients at Okayama University Hospital and Showa University Hospital were divided into three groups based on the onset era: a past-onset group (onset before 1995; n=83), middle-onset group (1996-2009; n=88), and recent-onset group (after 2010; n=74). The mean Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) score as an index of chronic damage was 1.93, 1.24, and 0.53 in the past-, middle-, and recent-onset groups, respectively. In the pastonset group, the total SDI score was significantly associated with glucocorticoid monotherapy by linear regression analysis (β-coefficient [β]=0.63; 95% confidence interval [CI], 0.21-1.05) and C-reactive protein levels (β=0.67; 95% CI, 0.27-1.07). In the middle-onset group, the total SDI score was significantly associated with the SLE Disease Activity Index at registration (β=0.09; 95% CI, 0.03-0.12). Reducing the accumulation of chronic damage in SLE patients might be possible with the concomitant use of immunosuppressants and tight control of disease activity. en-copyright= kn-copyright= en-aut-name=OhashiKeiji en-aut-sei=Ohashi en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SadaKen-Ei en-aut-sei=Sada en-aut-mei=Ken-Ei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AsanoYosuke en-aut-sei=Asano en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HayashiKeigo en-aut-sei=Hayashi en-aut-mei=Keigo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamamuraYuriko en-aut-sei=Yamamura en-aut-mei=Yuriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AsanoSumie Hiramatsu en-aut-sei=Asano en-aut-mei=Sumie Hiramatsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MiyawakiYoshia en-aut-sei=Miyawaki en-aut-mei=Yoshia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MorishitaMichiko en-aut-sei=Morishita en-aut-mei=Michiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KatsuyamaEri en-aut-sei=Katsuyama en-aut-mei=Eri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=WatanabeHaruki en-aut-sei=Watanabe en-aut-mei=Haruki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TatebeNoriko en-aut-sei=Tatebe en-aut-mei=Noriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NarazakiMariko en-aut-sei=Narazaki en-aut-mei=Mariko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=MatsumotoYoshinori en-aut-sei=Matsumoto en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=Sunahori-WatanabeKatsue en-aut-sei=Sunahori-Watanabe en-aut-mei=Katsue kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=KawabataTomoko en-aut-sei=Kawabata en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=YajimaNobuyuki en-aut-sei=Yajima en-aut-mei=Nobuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=13 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=14 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=15 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=16 en-affil=Division of Rheumatology, Department of Medicine, Showa University School of Medicine kn-affil= affil-num=17 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=systemic lupus erythematosus kn-keyword=systemic lupus erythematosus en-keyword=chronic damage kn-keyword=chronic damage en-keyword=glucocorticoids, disease activity kn-keyword=glucocorticoids, disease activity en-keyword=disease duration kn-keyword=disease duration END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190329 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=鹿田遺跡13 ー第26次調査ー (医学部動物実験施設改修に伴う発掘調査) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YamaguchiYuji en-aut-sei=Yamaguchi en-aut-mei=Yuji kn-aut-name=山口雄治 kn-aut-sei=山口 kn-aut-mei=雄治 aut-affil-num=1 ORCID= en-aut-name=MinamiKentaro en-aut-sei=Minami en-aut-mei=Kentaro kn-aut-name=南健太郎 kn-aut-sei=南 kn-aut-mei=健太郎 aut-affil-num=2 ORCID= en-aut-name=IwasakiShiho en-aut-sei=Iwasaki en-aut-mei=Shiho kn-aut-name=岩﨑志保 kn-aut-sei=岩﨑 kn-aut-mei=志保 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺正巳 kn-aut-sei=渡辺 kn-aut-mei=正巳 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=能城修一 kn-aut-sei=能城 kn-aut-mei=修一 aut-affil-num=5 ORCID= en-aut-name=OkiYoko en-aut-sei=Oki en-aut-mei=Yoko kn-aut-name=沖陽子 kn-aut-sei=沖 kn-aut-mei=陽子 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=江川達也 kn-aut-sei=江川 kn-aut-mei=達也 aut-affil-num=7 ORCID= affil-num=1 en-affil= Archaeological Research Center, Okayama University kn-affil=岡山大学埋蔵文化財調査研究センター affil-num=2 en-affil=Archaeological Research Center, Okayama University kn-affil=岡山大学埋蔵文化財調査研究センター affil-num=3 en-affil=Archaeological Research Center, Okayama University kn-affil=岡山大学埋蔵文化財調査研究センター affil-num=4 en-affil= kn-affil= affil-num=5 en-affil= kn-affil=明治大学 affil-num=6 en-affil= kn-affil=岡山大学 affil-num=7 en-affil= kn-affil=笠岡市教育委員会 END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue=4 article-no= start-page=45 end-page=47 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Cavernous Transformation and Granulomatous Epididymis in Behçet Disease en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MotokuraYumi en-aut-sei=Motokura en-aut-mei=Yumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WatanabeHaruki en-aut-sei=Watanabe en-aut-mei=Haruki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamamuraYuriko en-aut-sei=Yamamura en-aut-mei=Yuriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KanoYuzuki en-aut-sei=Kano en-aut-mei=Yuzuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MatsumotoYoshinori en-aut-sei=Matsumoto en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KawabataTomoko en-aut-sei=Kawabata en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SadaKen-ei en-aut-sei=Sada en-aut-mei=Ken-ei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology Endocrinology and Metabolism Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology Endocrinology and Metabolism Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Nephrology, Rheumatology Endocrinology and Metabolism Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Nephrology, Rheumatology Endocrinology and Metabolism Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Nephrology, Rheumatology Endocrinology and Metabolism Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Nephrology, Rheumatology Endocrinology and Metabolism Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Nephrology, Rheumatology Endocrinology and Metabolism Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Nephrology, Rheumatology Endocrinology and Metabolism Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue= article-no= start-page=3054 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=2019228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+T cells en-subtitle= kn-subtitle= en-abstract= kn-abstract=Global DNA hypomethylation in CD4+ cells in systemic lupus erythematosus (SLE) was suggested to play a key role in the pathogenesis. To identify new methylation-sensitive genes, we integrated genome-wide DNA methylation and mRNA profiling data in CD4+ cells of MRL/lpr (MRL) and C57BL6/J (B6) mice. We identified Cathepsin E (Ctse), in which 13 methyl-CpGs within 583 bp region of intron 1 were hypomethylated, and Ctse mRNA upregulated in MRL compared with B6 mice. One of methyl-CpGs, mCGCG was 93.3 +/- 2.05% methylated in B6 mice, while 80.0 +/- 6.2% methylated and mutated to CGGG in MRL mice. Kaiso is known to bind to mCGCG and we hypothesized that it represses expression of Ctse in B6 mice. The binding of Kaiso to mCGCG site in B6 mice was reduced in MRL mice revealed by ChIP-PCR. EL4 cells treated with 5-azaC and/or Trichostatin A showed the suppression of binding of Kaiso to mCGCG motif by ChIP-PCR and the overexpression of Ctse was demonstrated by qPCR. Ctse gene silencing by siRNA in EL4 cells resulted in reduction of IL-10 secretion. The hypomethylation of mCGCG motif, reduced recruitment of Kaiso, and increased expression of Ctse and Il-10 in CD4+ cells may be involved in the pathogenesis of SLE. en-copyright= kn-copyright= en-aut-name=HiramatsuSumie en-aut-sei=Hiramatsu en-aut-mei=Sumie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WatanabeKatsue S. en-aut-sei=Watanabe en-aut-mei=Katsue S. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ZeggarSonia en-aut-sei=Zeggar en-aut-mei=Sonia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AsanoYosuke en-aut-sei=Asano en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyawakiYoshia en-aut-sei=Miyawaki en-aut-mei=Yoshia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamamuraYuriko en-aut-sei=Yamamura en-aut-mei=Yuriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KatsuyamaEri en-aut-sei=Katsuyama en-aut-mei=Eri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KatsuyamaTakayuki en-aut-sei=Katsuyama en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=WatanabeHaruki en-aut-sei=Watanabe en-aut-mei=Haruki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=Takano-NarazakiMariko en-aut-sei=Takano-Narazaki en-aut-mei=Mariko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MatsumotoYoshinori en-aut-sei=Matsumoto en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=KawabataTomoko en-aut-sei=Kawabata en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=SadaKen-Ei en-aut-sei=Sada en-aut-mei=Ken-Ei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=13 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=14 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=抗High Mobility Group Box 1抗体は全身性エリトマトーデスモデルマウスにおいてアルブミン尿を軽減する kn-title=Anti-High Mobility Group Box 1 Antibody Ameliorates Albuminuria in MRL/lpr Lupus-Prone Mice en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeHaruki en-aut-sei=Watanabe en-aut-mei=Haruki kn-aut-name=渡辺晴樹 kn-aut-sei=渡辺 kn-aut-mei=晴樹 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=1707 cd-vols= no-issue= article-no= start-page=050013 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=2016 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Mathematical Formulation and Numerical Simulation of Bird Flu Infection Process within a Poultry Farm en-subtitle= kn-subtitle= en-abstract= kn-abstract= Bird flu infection processes within a poultry farm are formulated mathematically. A spatial effect is taken into account for the virus concentration with a diffusive term. An infection process is represented in terms of a traveling wave solutions. For a small removal rate, a singular perturbation analysis lead to existence of traveling wave solutions, that correspond to progressive infection in one direction. en-copyright= kn-copyright= en-aut-name=PutriArrival Rince en-aut-sei=Putri en-aut-mei=Arrival Rince kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NovaTertia Delia en-aut-sei=Nova en-aut-mei=Tertia Delia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WatanabeMasaji en-aut-sei=Watanabe en-aut-mei=Masaji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School Environmental and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Andalas University kn-affil= affil-num=3 en-affil=Graduate School Environmental and Life Science, Okayama University kn-affil= en-keyword=bird flu kn-keyword=bird flu en-keyword=spatial effect kn-keyword=spatial effect en-keyword=traveling wave solutions kn-keyword=traveling wave solutions en-keyword=singular perturbation kn-keyword=singular perturbation END start-ver=1.4 cd-journal=joma no-vol=1707 cd-vols= no-issue= article-no= start-page=050017 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=2016 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Numerical study on anaerobic digestion of fruit and vegetable waste: Biogas generation en-subtitle= kn-subtitle= en-abstract= kn-abstract= The study provides experimental results and numerical results concerning anaerobic digestion of fruit and vegetable waste. Experiments were carried out by using batch floating drum type digester without mixing and temperature setting. The retention time was 30 days. Numerical results based on Monod type model with influence of temperature is introduced. Initial value problems were analyzed numerically, while kinetic parameters were analyzed by using trial error methods. The numerical results for the first five days seems appropriate in comparison with the experimental outcomes. However, numerical results shows that the model is inappropriate for 30 days of fermentation. This leads to the conclusion that Monod type model is not suitable for describe the mixture degradation of fruit and vegetable waste and horse dung. en-copyright= kn-copyright= en-aut-name=WardhaniPuteri Kusuma en-aut-sei=Wardhani en-aut-mei=Puteri Kusuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WatanabeMasaji en-aut-sei=Watanabe en-aut-mei=Masaji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= en-keyword=Anaerobic digestion kn-keyword=Anaerobic digestion en-keyword=monod model kn-keyword=monod model en-keyword=numerical simulation kn-keyword=numerical simulation END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=2 article-no= start-page=111 end-page=114 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Adenocarcinoma in the jejunum 20 years after surgery for familial adenomatous polyposis kn-title=家族性大腸腺腫症術後20年後に小腸癌を発症した1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 58-year-old Japanese man visited a local clinic for the evaluation of a stomachache. He was diagnosed with intestinal obstruction. His medical history included a proctocolectomy at the age of 38 years, due to familial adenomatous polyposis (FAP). He was referred to our institution, where he underwent a computed tomography examination and endoscopy of the small intestine. The pathological diagnosis was adenocarcinoma. No invasive or metastatic lesions were observed. Therefore, partial resection of the ileum with lymphadenectomy and reconstruction of the ileostomy were performed. Pathological examination revealed that the tumor was type 2, pT3 (SS) , pN1, pPM0, pDM0, pRM0, INFb, ly1, v1, pEX0, PN0. Twenty-nine days after the surgery, the patient was diagnosed with lung metastasis and he underwent lung radiofrequency ablation. We suggest that long-term follow-up is necessary for patients after surgery for FAP, because of the risk of malignant disease developing in other organs. en-copyright= kn-copyright= en-aut-name=SugiharaYuusaku en-aut-sei=Sugihara en-aut-mei=Yuusaku kn-aut-name=杉原雄策 kn-aut-sei=杉原 kn-aut-mei=雄策 aut-affil-num=1 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name=川野誠司 kn-aut-sei=川野 kn-aut-mei=誠司 aut-affil-num=2 ORCID= en-aut-name=HaradaKeita en-aut-sei=Harada en-aut-mei=Keita kn-aut-name=原田馨太 kn-aut-sei=原田 kn-aut-mei=馨太 aut-affil-num=3 ORCID= en-aut-name=TakashimaShiho en-aut-sei=Takashima en-aut-mei=Shiho kn-aut-name=高嶋志保 kn-aut-sei=高嶋 kn-aut-mei=志保 aut-affil-num=4 ORCID= en-aut-name=TakeiDaisuke en-aut-sei=Takei en-aut-mei=Daisuke kn-aut-name=竹井大介 kn-aut-sei=竹井 kn-aut-mei=大介 aut-affil-num=5 ORCID= en-aut-name=InokuchiToshihiro en-aut-sei=Inokuchi en-aut-mei=Toshihiro kn-aut-name=井口俊博 kn-aut-sei=井口 kn-aut-mei=俊博 aut-affil-num=6 ORCID= en-aut-name=TakaharaMasahiro en-aut-sei=Takahara en-aut-mei=Masahiro kn-aut-name=高原政宏 kn-aut-sei=高原 kn-aut-mei=政宏 aut-affil-num=7 ORCID= en-aut-name=HiraokaSakiko en-aut-sei=Hiraoka en-aut-mei=Sakiko kn-aut-name=平岡佐規子 kn-aut-sei=平岡 kn-aut-mei=佐規子 aut-affil-num=8 ORCID= en-aut-name=MoriYoshiko en-aut-sei=Mori en-aut-mei=Yoshiko kn-aut-name=母里淑子 kn-aut-sei=母里 kn-aut-mei=淑子 aut-affil-num=9 ORCID= en-aut-name=KishimotoHiroyuki en-aut-sei=Kishimoto en-aut-mei=Hiroyuki kn-aut-name=岸本浩行 kn-aut-sei=岸本 kn-aut-mei=浩行 aut-affil-num=10 ORCID= en-aut-name=NagasakaTakeshi en-aut-sei=Nagasaka en-aut-mei=Takeshi kn-aut-name=永坂岳司 kn-aut-sei=永坂 kn-aut-mei=岳司 aut-affil-num=11 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=3 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=5 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=7 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=8 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=9 en-affil=Division of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 affil-num=10 en-affil=Division of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 affil-num=11 en-affil=Division of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 affil-num=12 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 en-keyword=家族性大腸腺腫症 (familial adenomatous polyposis) kn-keyword=家族性大腸腺腫症 (familial adenomatous polyposis) en-keyword=小腸癌 (jejunal cancer) kn-keyword=小腸癌 (jejunal cancer) en-keyword=小腸内視鏡検査 (small intestine endoscope) kn-keyword=小腸内視鏡検査 (small intestine endoscope) END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=1 article-no= start-page=23 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Changes of colonic mucosa caused by long-term use and discontinuation of anthraquinone kn-title=アントラキノンの長期連用，及び摂取中止が大腸粘膜に与える影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= Anthraquinone, an anthracene derivatives, is widely used as a purgative medicine. The long-term use of anthraquinone is known to cause melanosis coli and elevated lesions in the colon. However, the clinical course of patients who take anthraquinone over a long term and those who discontinue the drug has not been fully investigated. Here we investigated 22 patients who had colonic mucosal changes ( i.e., melanosis coli and elevated lesions) who had been taking anthraquinone for at least one year and discontinued it. We classified the elevated lesions into two subtypes:the small-lesion, which included multiple small nodules that were ＜ 2 mm in dia., and the large-lesion, which included a single or multiple nodules of ≥ 2-mm dia. We used colonoscopy to investigate the changes of colonic lesions between before and after the discontinuation of anthraquinone. The results indicated that the nodules of the small-lesion group were lymphoid follicle hyperplasia. In the large-lesion group, adenoma was most frequently observed ( n＝118) , followed by hyperplastic polyp ( n＝52) and inflammatory changes with edema ( n＝22) . Melanosis coli and elevated lesions were decreased or invisible after the discontinuation of anthraquinone. Our findings thus suggest that the long-term use of anthraquinone may cause some type of elevated lesions due to chronic inflammation. It is recommended that the use of anthraquinone be limited to a short term. en-copyright= kn-copyright= en-aut-name=IwanoEiji en-aut-sei=Iwano en-aut-mei=Eiji kn-aut-name=岩野英二 kn-aut-sei=岩野 kn-aut-mei=英二 aut-affil-num=1 ORCID= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name=岩室雅也 kn-aut-sei=岩室 kn-aut-mei=雅也 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=3 ORCID= affil-num=1 en-affil=Kamogata Clinic kn-affil=鴨方クリニック affil-num=2 en-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学 affil-num=3 en-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学 en-keyword=アントラセン誘導体（anthracene derivatives) kn-keyword=アントラセン誘導体（anthracene derivatives) en-keyword=アントラキノン（anthraquinone） kn-keyword=アントラキノン（anthraquinone） en-keyword=大腸黒皮症（melanosis coli） kn-keyword=大腸黒皮症（melanosis coli） en-keyword=大腸メラノーシス（pseudomelanosis coli） kn-keyword=大腸メラノーシス（pseudomelanosis coli） en-keyword=リンパ濾胞過形成（lymphoid follicle hyperplasia） kn-keyword=リンパ濾胞過形成（lymphoid follicle hyperplasia） END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=1 article-no= start-page=27 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Behçetʼs disease complicated by ileocecal and esophageal perforation kn-title=回盲部潰瘍穿孔，食道潰瘍穿孔をきたした腸管Behçet 病の1 手術例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 36-year-old Japanese man known to have incomplete Behçet’s disease (oral aphthous ulcers, genital ulcers, skin lesions, and esophageal and ileocecal ulcers) was admitted to our hospital in January 2011 for abdominal pain. We administered corticosteroids and immunosuppressants. Two months later, we performed an ileocecal resection to control gastrointestinal bleeding from the ileocecal ulcers. High fever persisted after this surgery, and upper gastrointestinal endoscopy demonstrated ulcer penetration between the lower and abdominal esophagus. Eighteen days after the initial ileocecal resection, we performed a lower esophagus resection, gastric tube reconstruction and enterostomy, during which we confirmed a 5-mm-dia. perforated site at the posterior wall of the abdominal esophagus. Postoperative anastomotic leakage and empyema occurred, but they were relieved by thoracic drainage and empyema dissection. en-copyright= kn-copyright= en-aut-name=TsukumoYuta en-aut-sei=Tsukumo en-aut-mei=Yuta kn-aut-name=九十九悠太 kn-aut-sei=九十九 kn-aut-mei=悠太 aut-affil-num=1 ORCID= en-aut-name=KawamotoKazuyuki en-aut-sei=Kawamoto en-aut-mei=Kazuyuki kn-aut-name=河本和幸 kn-aut-sei=河本 kn-aut-mei=和幸 aut-affil-num=2 ORCID= en-aut-name=TakagiKosei en-aut-sei=Takagi en-aut-mei=Kosei kn-aut-name=高木弘誠 kn-aut-sei=高木 kn-aut-mei=弘誠 aut-affil-num=3 ORCID= en-aut-name=ChinKai en-aut-sei=Chin en-aut-mei=Kai kn-aut-name=陳開 kn-aut-sei=陳 kn-aut-mei=開 aut-affil-num=4 ORCID= en-aut-name=MatsubaYuri en-aut-sei=Matsuba en-aut-mei=Yuri kn-aut-name=松葉優里 kn-aut-sei=松葉 kn-aut-mei=優里 aut-affil-num=5 ORCID= en-aut-name=NagahisaYoshio en-aut-sei=Nagahisa en-aut-mei=Yoshio kn-aut-name=長久吉雄 kn-aut-sei=長久 kn-aut-mei=吉雄 aut-affil-num=6 ORCID= en-aut-name=OkabeMichio en-aut-sei=Okabe en-aut-mei=Michio kn-aut-name=岡部道雄 kn-aut-sei=岡部 kn-aut-mei=道雄 aut-affil-num=7 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name=白川靖博 kn-aut-sei=白川 kn-aut-mei=靖博 aut-affil-num=8 ORCID= en-aut-name=ItohTadashi en-aut-sei=Itoh en-aut-mei=Tadashi kn-aut-name=伊藤雅 kn-aut-sei=伊藤 kn-aut-mei=雅 aut-affil-num=9 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=2 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=4 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=5 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=6 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=7 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=9 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 en-keyword=ベーチェット病（Behçet’s disease） kn-keyword=ベーチェット病（Behçet’s disease） en-keyword=食道（esophagus） kn-keyword=食道（esophagus） en-keyword=回盲部（ileocecal） kn-keyword=回盲部（ileocecal） en-keyword=穿孔（perforation） kn-keyword=穿孔（perforation） en-keyword=手術（surgery） kn-keyword=手術（surgery） END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=1 article-no= start-page=21 end-page=25 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of mucinous adenocarcinoma of the duodenum and literature review of 16 cases reported in Japan kn-title=原発性十二指腸粘液癌の一例― 本邦報告16例の検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=　Primary mucinous adenocarcinoma of the duodenum is rare. Here we report a case we recently encountered, and we review 16 cases reported in Japan. An 82-year-old Japanese woman was admitted to our hospital complaining of abdominal pain and heartburn. An endoscopic examination revealed a Type 2 tumor in the descending limb of the duodenum, and endoscopically obtained specimens revealed a poorly differentiated adenocarcinoma. We performed a curative pancreatoduodenectomy with lymph node resection, and the surgical specimen revealed that the duodenum was the primary site of the mucinous adenocarcinoma. The patient is currently alive ＞ 1 year after the operation without any evidence of recurrence. Of the 16 patients reviewed, all patients had advanced tumors those depth were T3-T4. 9 patients had lymph node metastasis and 4 patients had peritoneal dissemination at the time of surgery. Since mucinous adenocarcinoma of the duodenum is often progressive cancer at a diagnosis, which is tend to have a worse prognosis than other histological types. en-copyright= kn-copyright= en-aut-name=HamanoIkumi en-aut-sei=Hamano en-aut-mei=Ikumi kn-aut-name=浜野郁美 kn-aut-sei=浜野 kn-aut-mei=郁美 aut-affil-num=1 ORCID= en-aut-name=MatsumotoYusuke en-aut-sei=Matsumoto en-aut-mei=Yusuke kn-aut-name=松本祐介 kn-aut-sei=松本 kn-aut-mei=祐介 aut-affil-num=2 ORCID= en-aut-name=EndoYoshikatsu en-aut-sei=Endo en-aut-mei=Yoshikatsu kn-aut-name=遠藤芳克 kn-aut-sei=遠藤 kn-aut-mei=芳克 aut-affil-num=3 ORCID= en-aut-name=WatanabeNaoki en-aut-sei=Watanabe en-aut-mei=Naoki kn-aut-name=渡邊直樹 kn-aut-sei=渡邊 kn-aut-mei=直樹 aut-affil-num=4 ORCID= en-aut-name=KaiKyouhei en-aut-sei=Kai en-aut-mei=Kyouhei kn-aut-name=甲斐恭平 kn-aut-sei=甲斐 kn-aut-mei=恭平 aut-affil-num=5 ORCID= en-aut-name=SatoShizou en-aut-sei=Sato en-aut-mei=Shizou kn-aut-name=佐藤四三 kn-aut-sei=佐藤 kn-aut-mei=四三 aut-affil-num=6 ORCID= en-aut-name=WaniYoji en-aut-sei=Wani en-aut-mei=Yoji kn-aut-name=和仁洋治 kn-aut-sei=和仁 kn-aut-mei=洋治 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=2 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=3 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=4 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=5 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=6 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=7 en-affil= kn-affil=姫路赤十字病院　病理診断科 en-keyword=原発性十二指腸癌（primary duodenal cancer） kn-keyword=原発性十二指腸癌（primary duodenal cancer） en-keyword=粘液癌（mucinous carcinoma） kn-keyword=粘液癌（mucinous carcinoma） en-keyword=膵頭十二指腸切除（pancreatoduodenectomy） kn-keyword=膵頭十二指腸切除（pancreatoduodenectomy） END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=3 article-no= start-page=219 end-page=222 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20151201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Drug-induced liver injury due to the long-term oral administration of rosuvastatin kn-title=長期のロスバスタチンカルシウム服用にて発症したと考えられる薬物性肝障害の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 67-year-old man was admitted to our hospital presenting with a liver injury. He had used several types of oral medication for the prior 2 years, including rosuvastatin calcium for hypertension, hyperlipidemia, and prostatic hypertrophy. His liver dysfunction was noted for the first time in February 2013, and at re-examination in March 2013 he showed exacerbation of the liver dysfunction, he was admitted to our hospital at that time. We stopped all of his oral medications, and his liver function improved steadily. We conducted a drug-induced lymphocyte transformation test (DLST), and the rosuvastatin calcium result was positive. He was diagnosed as having a drug-induced (by rosvastatin calcium) liver injury. He resumed oral medications other than rosuvastatin calcium from the time of discharge, with no exacerbation of liver dysfunction since then. Reports of drug-induced liver injury due to drugs with a long-term oral administration are extremely rare. We discuss the relevant literature herein. en-copyright= kn-copyright= en-aut-name=OonishiAyano en-aut-sei=Oonishi en-aut-mei=Ayano kn-aut-name=大西理乃 kn-aut-sei=大西 kn-aut-mei=理乃 aut-affil-num=1 ORCID= en-aut-name=KariyamaKazuya en-aut-sei=Kariyama en-aut-mei=Kazuya kn-aut-name=狩山和也 kn-aut-sei=狩山 kn-aut-mei=和也 aut-affil-num=2 ORCID= en-aut-name=WakutaAkiko en-aut-sei=Wakuta en-aut-mei=Akiko kn-aut-name=湧田暁子 kn-aut-sei=湧田 kn-aut-mei=暁子 aut-affil-num=3 ORCID= en-aut-name=NishimuraMamoru en-aut-sei=Nishimura en-aut-mei=Mamoru kn-aut-name=西村守 kn-aut-sei=西村 kn-aut-mei=守 aut-affil-num=4 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name=能祖一裕 kn-aut-sei=能祖 kn-aut-mei=一裕 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山市立市民病院 affil-num=2 en-affil= kn-affil=岡山市立市民病院 affil-num=3 en-affil= kn-affil=岡山市立市民病院 affil-num=4 en-affil= kn-affil=岡山市立市民病院 affil-num=5 en-affil= kn-affil=岡山市立市民病院 en-keyword=薬物性肝障害（drug induced liver injury） kn-keyword=薬物性肝障害（drug induced liver injury） en-keyword=ロスバスタチンカルシウム（Rosuvastatin） kn-keyword=ロスバスタチンカルシウム（Rosuvastatin） en-keyword=スタチン（statin） kn-keyword=スタチン（statin） en-keyword=DLST kn-keyword=DLST END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=3 article-no= start-page=203 end-page=207 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20151201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Non-high-output cardiac failure in patients undergoing hemodialysis through an arteriovenous shunt kn-title=透析シャント心不全―非過大シャント心不全 “Non-High-Output Cardiac Failure”の病態― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Hemodialysis-related heart failure has been considered to be associated with excessive blood flow through the arteriovenous (AV) shunt used for vascular access. However, some patients undergoing dialysis have heart failure in the absence of an increase in cardiac output (CO) related to shunt blood-flow loading because the loading cannot be compensated for by increasing CO. This condition may be challenging to manage ; thus, early diagnosis is important. Methods and Results: Twelve patients (mean age, 71 years ; 9 men) with end-stage renal disease, dialysis-related heart failure, a high brain natriuretic peptide (BNP) level, and a mean New York Heart Association (NYHA) class of II underwent AV shunt closure. Their cardiac index (CI), pre- and post-dialysis BNP levels, and several cardiac variables were assessed pre- and postoperatively. All patients achieved relief of heart failure symptoms and a reduction in NYHA class after AV closure, but six patients had a postoperative increase in CI (the "non-high-output" cardiac failure group), whereas the other six had a decrease in CI (the "high-output" cardiac failure group). The high-output patients had greater improvements in BNP levels and most cardiac variables compared to the non-high-output group ; therefore, the heart failure in the non-high-output patients was considered more serious than that in the high-output group. Conclusions: The selection of effective strategies for treating dialysis-related heart failure may depend partly on identifying which patients have non-high-output failure. Such identification requires serial measurements of BNP levels and evaluations of cardiac variables other than the ejection fraction. en-copyright= kn-copyright= en-aut-name=UgawaToyomu en-aut-sei=Ugawa en-aut-mei=Toyomu kn-aut-name=鵜川豊世武 kn-aut-sei=鵜川 kn-aut-mei=豊世武 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 en-keyword=心拍出量（cardiac output） kn-keyword=心拍出量（cardiac output） en-keyword=心不全（heart failure） kn-keyword=心不全（heart failure） en-keyword=脳性ナトリウム利尿ペプチド（brain natriuretic peptide） kn-keyword=脳性ナトリウム利尿ペプチド（brain natriuretic peptide） en-keyword=非過大シャント心不全（non-high-output cardiac failure） kn-keyword=非過大シャント心不全（non-high-output cardiac failure） en-keyword=腎臓（kidney） kn-keyword=腎臓（kidney） END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue=15 article-no= start-page=1147 end-page=1160 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130722 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Positioning device for outdoor mobile robots using optical sensors and lasers en-subtitle= kn-subtitle= en-abstract= kn-abstract=We propose a novel method for positioning a mobile robot in an outdoor environment using lasers and optical sensors. Position estimation via a noncontact optical method is useful because the information from the wheel odometer and the global positioning system in a mobile robot is unreliable in some situations. Contact optical sensors such as computer mouse are designed to be in contact with a surface and do not function well in strong ambient light conditions. To mitigate the challenges of an outdoor environment, we developed an optical device with a bandpass filter and a pipe to restrict solar light and to detect translation. The use of two devices enables sensing of the mobile robot’s position, including posture. Furthermore, employing a collimated laser beam allows measurements against a surface to be invariable with the distance to the surface. In this paper, we describe motion estimation, device configurations, and several tests for performance evaluation. We also present the experimental positioning results from a vehicle equipped with our optical device on an outdoor path. Finally, we discuss an improvement in postural accuracy by combining an optical device with precise gyroscopes. en-copyright= kn-copyright= en-aut-name=NagaiIsaku en-aut-sei=Nagai en-aut-mei=Isaku kn-aut-name=永井伊作 kn-aut-sei=永井 kn-aut-mei=伊作 aut-affil-num=1 ORCID= en-aut-name=YamauchiGenki en-aut-sei=Yamauchi en-aut-mei=Genki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NagataniKeiji en-aut-sei=Nagatani en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=WatanabeKeigo en-aut-sei=Watanabe en-aut-mei=Keigo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YoshidaKazuya en-aut-sei=Yoshida en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=自然科学研究科 affil-num=2 en-affil= kn-affil=Graduate School of Engineering, Tohoku University affil-num=3 en-affil= kn-affil=Graduate School of Engineering, Tohoku University affil-num=4 en-affil= kn-affil=Department of Intelligent Mechanical Systems , Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Engineering, Tohoku University en-keyword=mobile robot kn-keyword=mobile robot en-keyword=position estimation kn-keyword=position estimation en-keyword=laser speckle pattern kn-keyword=laser speckle pattern en-keyword=optical sensor kn-keyword=optical sensor END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=6053 end-page=6058 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150928 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Path Tracking by a Mobile Robot Equipped with Only a Downward Facing Camera en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper presents a practical path-tracking method for a mobile robot with only a downward camera facing the passage plane. A unique algorithm for tracking and searching ground images with natural texture is used to localize the robot without a feature-point extraction scheme commonly used in other visual odometry methods. In our tracking algorithm, groups of reference pixels are used to detect the relative translation and rotation between frames. Furthermore, a reference pixel group of another shape is registered both to record a path and to correct errors accumulated during localization. All image processing and robot control operations are carried out with low memory consumption for image registration and fast calculation times for completing the searches on a laptop PC. We also describe experimental results in which a vehicle developed by the proposed method repeatedly performed precise path tracking under indoor and outdoor environments. en-copyright= kn-copyright= en-aut-name=NagaiIsaku en-aut-sei=Nagai en-aut-mei=Isaku kn-aut-name=永井伊作 kn-aut-sei=永井 kn-aut-mei=伊作 aut-affil-num=1 ORCID= en-aut-name=WatanabeKeigo en-aut-sei=Watanabe en-aut-mei=Keigo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院自然科学研究科 affil-num=2 en-affil= kn-affil=岡山大学大学院自然科学研究科 END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=2 article-no= start-page=117 end-page=121 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150803 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Successful laparoscopic resection of a cecal tumor in a 95-year-old man kn-title=超高齢者（95歳）の進行盲腸癌に対して腹腔鏡下回盲部切除を施行した1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report a successful laparoscopic resection of a cecal tumor in a 95-year-old Japanese man. The patient visited an initial hospital with a complaint of constipation in March 2014. Computed tomography scan and colonoscopy showed a stenotic ileocecal cancer with pericolic lymph node metastases, and he was referred to our department for management. Since his general condition was maintained, we performed a laparoscopic ileocecal resection with regional lymph node dissection for the patient. The operation achieved curative resection, and the tumor was diagnosed as a moderately differentiated adenocarcinoma and graded as pStage IIIa (pT3, pN0, pM0) according to the Japanese Classification of Colorectal Carcinoma, eighth edition. He was discharged on the 11th postoperative day without perioperative complications. Several large-scale randomized controlled trials （RCTs） revealed that laparoscopic surgeries for colorectal cancers have some advantages compared to open surgeries, including superior short-term outcomes and comparable long-term outcomes. Unfortunately, since these RCTs did not include enough elderly patients, the safety and feasibility of laparoscopic surgery for extremely elderly patients are still unknown. With respect to less-invasive procedures, these advantages of laparoscopic surgery are also thought to be the advantages for elderly colorectal cancer patients. en-copyright= kn-copyright= en-aut-name=WatanabeAyako en-aut-sei=Watanabe en-aut-mei=Ayako kn-aut-name=渡邉彩子 kn-aut-sei=渡邉 kn-aut-mei=彩子 aut-affil-num=1 ORCID= en-aut-name=InadaRyo en-aut-sei=Inada en-aut-mei=Ryo kn-aut-name=稲田涼 kn-aut-sei=稲田 kn-aut-mei=涼 aut-affil-num=2 ORCID= en-aut-name=NagasakaTakeshi en-aut-sei=Nagasaka en-aut-mei=Takeshi kn-aut-name=永坂岳司 kn-aut-sei=永坂 kn-aut-mei=岳司 aut-affil-num=3 ORCID= en-aut-name=YagiTomohiko en-aut-sei=Yagi en-aut-mei=Tomohiko kn-aut-name=八木朝彦 kn-aut-sei=八木 kn-aut-mei=朝彦 aut-affil-num=4 ORCID= en-aut-name=MatsumotoHijiri en-aut-sei=Matsumoto en-aut-mei=Hijiri kn-aut-name=松本聖 kn-aut-sei=松本 kn-aut-mei=聖 aut-affil-num=5 ORCID= en-aut-name=ToshimaToshiaki en-aut-sei=Toshima en-aut-mei=Toshiaki kn-aut-name=戸嶋俊明 kn-aut-sei=戸嶋 kn-aut-mei=俊明 aut-affil-num=6 ORCID= en-aut-name=KikuchiSatoru en-aut-sei=Kikuchi en-aut-mei=Satoru kn-aut-name=菊池覚次 kn-aut-sei=菊池 kn-aut-mei=覚次 aut-affil-num=7 ORCID= en-aut-name=KurodaShinshi en-aut-sei=Kuroda en-aut-mei=Shinshi kn-aut-name=黒田新士 kn-aut-sei=黒田 kn-aut-mei=新士 aut-affil-num=8 ORCID= en-aut-name=KondoYoshitaka en-aut-sei=Kondo en-aut-mei=Yoshitaka kn-aut-name=近藤喜太 kn-aut-sei=近藤 kn-aut-mei=喜太 aut-affil-num=9 ORCID= en-aut-name=MoriYoshiko en-aut-sei=Mori en-aut-mei=Yoshiko kn-aut-name=母里淑子 kn-aut-sei=母里 kn-aut-mei=淑子 aut-affil-num=10 ORCID= en-aut-name=KishimotoHiroyuki en-aut-sei=Kishimoto en-aut-mei=Hiroyuki kn-aut-name=岸本浩行 kn-aut-sei=岸本 kn-aut-mei=浩行 aut-affil-num=11 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=12 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 en-keyword=超高齢者（extremely elderly patient） kn-keyword=超高齢者（extremely elderly patient） en-keyword=大腸癌（colorectal cancer） kn-keyword=大腸癌（colorectal cancer） en-keyword=腹腔鏡手術（laparoscopic surgery） kn-keyword=腹腔鏡手術（laparoscopic surgery） END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=３歳児う蝕罹患にかかわる生活習慣の要因に関する分析 kn-title=The Influence of Lifestyle on the Incidence of Dental Caries among 3-Year-Old Japanese Children en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeMasako en-aut-sei=Watanabe en-aut-mei=Masako kn-aut-name=渡辺雅子 kn-aut-sei=渡辺 kn-aut-mei=雅子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=1 article-no= start-page=13 end-page=17 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Okayama University Survey of the current situation of community-based medical facilities supported by part-time work by physicians kn-title=岡山大学勤務医師による非常勤勤務を通した地域医療支援の現状調査 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　We investigated the situation of how physicians at Okayama University support local medical institutions by serving as a part-time worker, and analyzed the difference between the five medical districts of Okayama prefecture and other prefectures. Many physicians (actual number of physicians, full-time equivalent number of physicians) served in the southeastern region of the Okayama prefecture (339, 82.2). On the other hand, fewer physicians (42, 11.4) served in Takahashi・Niimi in the northwestern region of Okayama. Many physicians also served in Hiroshima prefecture (193, 48.8), Hyogo prefecture (109, 26.7), and the four prefectures of Shikoku Island (81, 23.6). 　It has been clarified that many physicians at Okayama University are working on a part-time basis to support local and community medical institutions in the wide area of Okayama prefecture, Hiroshima prefecture, Hyogo prefecture and the four prefectures of Shikoku Island. en-copyright= kn-copyright= en-aut-name=TeshigawaraSanae en-aut-sei=Teshigawara en-aut-mei=Sanae kn-aut-name=勅使川早苗 kn-aut-sei=勅使川 kn-aut-mei=早苗 aut-affil-num=1 ORCID= en-aut-name=IwaseToshihide en-aut-sei=Iwase en-aut-mei=Toshihide kn-aut-name=岩瀬敏秀 kn-aut-sei=岩瀬 kn-aut-mei=敏秀 aut-affil-num=2 ORCID= en-aut-name=KanamoriTatsuya en-aut-sei=Kanamori en-aut-mei=Tatsuya kn-aut-name=金森達也 kn-aut-sei=金森 kn-aut-mei=達也 aut-affil-num=3 ORCID= en-aut-name=KawabataTomoko en-aut-sei=Kawabata en-aut-mei=Tomoko kn-aut-name=川畑智子 kn-aut-sei=川畑 kn-aut-mei=智子 aut-affil-num=4 ORCID= en-aut-name=SatoMasaru en-aut-sei=Sato en-aut-mei=Masaru kn-aut-name=佐藤勝 kn-aut-sei=佐藤 kn-aut-mei=勝 aut-affil-num=5 ORCID= en-aut-name=Usui KataokaHitomi en-aut-sei=Usui Kataoka en-aut-mei=Hitomi kn-aut-name=片岡仁美 kn-aut-sei=片岡 kn-aut-mei=仁美 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　地域医療人材育成 affil-num=2 en-affil= kn-affil=岡山県地域医療支援センター　岡山大学支部 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　地域医療人材育成 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　地域医療人材育成 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　地域医療人材育成 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　地域医療人材育成 en-keyword=岡山大学勤務医師（physicians at Okayama University） kn-keyword=岡山大学勤務医師（physicians at Okayama University） en-keyword=非常勤勤務（part-time worker） kn-keyword=非常勤勤務（part-time worker） en-keyword=地域医療機関支援（community-based medical facilities） kn-keyword=地域医療機関支援（community-based medical facilities） END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=109 end-page=115 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Comprehensive treatment for gender identity disorder kn-title=性同一性障害に対する包括的治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NambaYuzaburo en-aut-sei=Namba en-aut-mei=Yuzaburo kn-aut-name=難波祐三郎 kn-aut-sei=難波 kn-aut-mei=祐三郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　ジェンダーセンター en-keyword=性同一性障害 kn-keyword=性同一性障害 en-keyword=包括的治療 kn-keyword=包括的治療 en-keyword=性別適合手術 kn-keyword=性別適合手術 END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=1 article-no= start-page=17 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Concept and management of pancreaticobiliary maljunction kn-title=膵・胆管合流異常症―その概念と治療― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NodaTakuo en-aut-sei=Noda en-aut-mei=Takuo kn-aut-name=野田卓男 kn-aut-sei=野田 kn-aut-mei=卓男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　小児外科 en-keyword=膵・胆管合流異常 kn-keyword=膵・胆管合流異常 en-keyword=先天性胆道拡張症 kn-keyword=先天性胆道拡張症 en-keyword=分流手術胆道癌 kn-keyword=分流手術胆道癌 END start-ver=1.4 cd-journal=joma no-vol=3 cd-vols= no-issue= article-no= start-page=1 end-page=5 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960608 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=10の合成・分解の理解と習熟を図るための十面体のサイコロの効果的な使い方 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺美智子 kn-aut-sei=渡辺 kn-aut-mei=美智子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山市立御南小学校 END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue= article-no= start-page=101 end-page=103 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=高等学校学習指導要領の改訂について ―高等学校普通科の現場から― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺哲夫 kn-aut-sei=渡辺 kn-aut-mei=哲夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山県立総社南高等学校 END start-ver=1.4 cd-journal=joma no-vol=43 cd-vols= no-issue=3 article-no= start-page=134 end-page=143 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19551125 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the biological control of plant diseases by utilization of antagonistic organisms on the pathogens. X. Control of plant diseases by Trichoderma species. 3. Ruslts of experiments in pots and in fields. kn-title=拮抗微生物による作物病害防除研究 第10報 Trichoderma属菌利用による植物病害の防除 (その3) ポットおよび圃場試験 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NisikadoY. en-aut-sei=Nisikado en-aut-mei=Y. kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=1 ORCID= en-aut-name=WatanabeK. en-aut-sei=Watanabe en-aut-mei=K. kn-aut-name=渡辺淸志 kn-aut-sei=渡辺 kn-aut-mei=淸志 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=43 cd-vols= no-issue=3 article-no= start-page=126 end-page=133 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19551125 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the biological control of plant diseases by utilization of antagonistic organisms on the pathogens. IX. Control of plant diseases by Trichoderma species. 2. On the propagation of Trichoderma spp. in soil and the effect of acid substance on massproduction of culture. kn-title=拮抗微生物による作物病害防除研究 第9報 Trichoderma属菌利用による植物病害の防除 (その2) 土壤中でのTrichoderma属菌の増殖,およびその大量培養と酸性物質との関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NisikadoY. en-aut-sei=Nisikado en-aut-mei=Y. kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=1 ORCID= en-aut-name=WatanabeK. en-aut-sei=Watanabe en-aut-mei=K. kn-aut-name=渡辺淸志 kn-aut-sei=渡辺 kn-aut-mei=淸志 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue=2 article-no= start-page=115 end-page=119 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the rhizome rot of rotus, Nelumbo nucifera Gaertn.，caused by a new Fusarium, F. bulbigenum Wr. var. nelumbicolum N. et W. kn-title=蓮根の腐敗病に就いて 第一報 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NisikadoY. en-aut-sei=Nisikado en-aut-mei=Y. kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=1 ORCID= en-aut-name=WatanabeK. en-aut-sei=Watanabe en-aut-mei=K. kn-aut-name=渡辺淸志 kn-aut-sei=渡辺 kn-aut-mei=淸志 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=153 cd-vols= no-issue= article-no= start-page=59 end-page=69 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130725 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Consideration of a Choral Warm-up II ―from a Viewpoint of “Physical Relaxation”― kn-title=合唱のウォームアップに関する考察(2)身体のリラックスの視点から en-subtitle= kn-subtitle= en-abstract= kn-abstract=合唱のウォームアップについて，合唱指導者の取り組みや合唱団の事例を通して，身体の リラックスの視点から考察した。野口体操や体ほぐしを取り入れた合唱指導者渡辺，岩崎， 橋本ら３者は，身体の柔軟性が良好な発声を導くという考えに基づいていることを示してお り，また，岩崎，橋本は，心理的柔軟性もその条件に付加していることが明らかになった。 次に，合唱団の実践例から，全体的に，身体的な観点からは「呼吸」と「姿勢」を大切にし た指導が行われ，上肢部分のストレッチに重点が置かれていることがわかった。他方，心理 的観点からは仲間との触れ合いを取り入れて心をほぐすなどの工夫が見られた。さらに，呼 吸と運動（動き）を同時に行う，合唱団員の年齢に応じた活動を取り入れるなどの工夫も見 られ，これらの活動が，息が自然に声につながるための手立てとなる示唆を得た。 en-copyright= kn-copyright= en-aut-name=MushiakiMasako en-aut-sei=Mushiaki en-aut-mei=Masako kn-aut-name=虫明眞砂子 kn-aut-sei=虫明 kn-aut-mei=眞砂子 aut-affil-num=1 ORCID= en-aut-name=KuroiKaori en-aut-sei=Kuroi en-aut-mei=Kaori kn-aut-name=黒井かおり kn-aut-sei=黒井 kn-aut-mei=かおり aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= en-keyword=体ほぐし kn-keyword=体ほぐし en-keyword=リラックス kn-keyword=リラックス en-keyword=呼吸 kn-keyword=呼吸 en-keyword=合唱 kn-keyword=合唱 en-keyword=ウォームアップ kn-keyword=ウォームアップ END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=少量のミダゾラム投与による高血圧歯科患者の血圧安定化効果—二重盲検ランダム化比較試験— en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeYoshihisa en-aut-sei=Watanabe en-aut-mei=Yoshihisa kn-aut-name=渡辺禎久 kn-aut-sei=渡辺 kn-aut-mei=禎久 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue=4 article-no= start-page=206 end-page=217 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=195903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ヤマハンノキ芽枯病 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺淸志 kn-aut-sei=渡辺 kn-aut-mei=淸志 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=井上成信 kn-aut-sei=井上 kn-aut-mei=成信 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=44 cd-vols= no-issue=2 article-no= start-page=56 end-page=64 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=195610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=蓮根腐敗病防除試験 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺淸志 kn-aut-sei=渡辺 kn-aut-mei=淸志 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=43 cd-vols= no-issue=2 article-no= start-page=103 end-page=112 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550620 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=拮抗微生物による作物病害防除硏究　第8報　Trichoderma属菌の利用による植物病害防除（その一）　Trichoderma菌の各種菌核に対する抗菌作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺淸志 kn-aut-sei=渡辺 kn-aut-mei=淸志 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=4 article-no= start-page=133 end-page=141 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550125 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=コムギ赤カビ病の第一次発生に関する硏究　第2報　子囊殻の形成について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=井上成信 kn-aut-sei=井上 kn-aut-mei=成信 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺淸志 kn-aut-sei=渡辺 kn-aut-mei=淸志 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=3 article-no= start-page=89 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19541225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=蓮根の新病害炭疽病について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺淸志 kn-aut-sei=渡辺 kn-aut-mei=淸志 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=2 article-no= start-page=49 end-page=56 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=蓮根の腐敗病について　第2報　病原Fusarium菌の生態 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺淸志 kn-aut-sei=渡辺 kn-aut-mei=淸志 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue=1 article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=1951 dt-pub=19511020 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=クリの葉枯病に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺淸志 kn-aut-sei=渡辺 kn-aut-mei=淸志 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=1 article-no= start-page=73 end-page=75 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Drug interaction(26. combination with therapeutic drugs used to treat hyperuricemia) kn-title=薬物相互作用(26―高尿酸血症治療薬の薬物相互作用） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MakitaTakashi en-aut-sei=Makita en-aut-mei=Takashi kn-aut-name=槇田崇志 kn-aut-sei=槇田 kn-aut-mei=崇志 aut-affil-num=1 ORCID= en-aut-name=KitamuraYoshihisa en-aut-sei=Kitamura en-aut-mei=Yoshihisa kn-aut-name=北村佳久 kn-aut-sei=北村 kn-aut-mei=佳久 aut-affil-num=2 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name=千堂年昭 kn-aut-sei=千堂 kn-aut-mei=年昭 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=2 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=3 en-affil= kn-affil=岡山大学病院　薬剤部 END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=3 article-no= start-page=243 end-page=247 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20121203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of intracystic carcinoma of the breast showing pathological complete response by neoadjuvant chemotherapy kn-title=術前化学療法により壁が菲薄化し組織学的寛解（pCR）となった巨大嚢胞内乳癌の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 31-year-old woman presented to our hospital because of a lump 5cm in diameter in her right breast. Ultrasonography revealed a multilocular cystic mass with partial thickening of the wall and the septum. Core needle biopsy (CNB) of the septum confirmed invasive ductal carcinoma. The patient was administered neoadjuvant chemotherapy consisting of 12 cycles of weekly paclitaxel followed by 4 cycles of FEC (5FU, Epilubicin and cyclophosphamide). While the thickness of the wall and septum became thinner, the tumor size did not change in diameter. She underwent right mastectomy and sentinel node biopsy. Post-surgical histopathological findings showed a pathological complete response (pCR).
　We report a rare case of invasive ductal carcinoma presenting a multilobular phenotype which showed pCR by neoadjuvant chemotherapy despite no size reduction of the tumor. en-copyright= kn-copyright= en-aut-name=ImadaTakako en-aut-sei=Imada en-aut-mei=Takako kn-aut-name=今田孝子 kn-aut-sei=今田 kn-aut-mei=孝子 aut-affil-num=1 ORCID= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=2 ORCID= en-aut-name=MotokiTakayuki en-aut-sei=Motoki en-aut-mei=Takayuki kn-aut-name=元木崇之 kn-aut-sei=元木 kn-aut-mei=崇之 aut-affil-num=3 ORCID= en-aut-name=IwamotoTakayuki en-aut-sei=Iwamoto en-aut-mei=Takayuki kn-aut-name=岩本高行 kn-aut-sei=岩本 kn-aut-mei=高行 aut-affil-num=4 ORCID= en-aut-name=OomoriMasako en-aut-sei=Oomori en-aut-mei=Masako kn-aut-name=大森昌子 kn-aut-sei=大森 kn-aut-mei=昌子 aut-affil-num=5 ORCID= en-aut-name=IhaSigemichi en-aut-sei=Iha en-aut-mei=Sigemichi kn-aut-name=伊波茂道 kn-aut-sei=伊波 kn-aut-mei=茂道 aut-affil-num=6 ORCID= en-aut-name=HongoToshie en-aut-sei=Hongo en-aut-mei=Toshie kn-aut-name=本後登志江 kn-aut-sei=本後 kn-aut-mei=登志江 aut-affil-num=7 ORCID= en-aut-name=HenmiNoriko en-aut-sei=Henmi en-aut-mei=Noriko kn-aut-name=逸見典子 kn-aut-sei=逸見 kn-aut-mei=典子 aut-affil-num=8 ORCID= en-aut-name=MakabeMikio en-aut-sei=Makabe en-aut-mei=Mikio kn-aut-name=真壁幹夫 kn-aut-sei=真壁 kn-aut-mei=幹夫 aut-affil-num=9 ORCID= en-aut-name=NogamiHiromi en-aut-sei=Nogami en-aut-mei=Hiromi kn-aut-name=野上浩實 kn-aut-sei=野上 kn-aut-mei=浩實 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=5 en-affil= kn-affil=岡山大学病院　病理診断科 affil-num=6 en-affil= kn-affil=岡山大福クリニック affil-num=7 en-affil= kn-affil=岡山大福クリニック affil-num=8 en-affil= kn-affil=岡山大福クリニック affil-num=9 en-affil= kn-affil=岡山中央病院 affil-num=10 en-affil= kn-affil=野上病院 en-keyword=嚢胞内乳癌（intracystic breast cancer） kn-keyword=嚢胞内乳癌（intracystic breast cancer） en-keyword=術前化学療法（neoadjuvant chemotherapy） kn-keyword=術前化学療法（neoadjuvant chemotherapy） en-keyword=組織学的完全奏功（pahthological CR） kn-keyword=組織学的完全奏功（pahthological CR） END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=2 article-no= start-page=141 end-page=144 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Japanese guideline for management of lateral epicondylitis kn-title=上腕骨外側上顆炎の診療ガイドライン en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ShimamuraYasunori en-aut-sei=Shimamura en-aut-mei=Yasunori kn-aut-name=島村安則 kn-aut-sei=島村 kn-aut-mei=安則 aut-affil-num=1 ORCID= en-aut-name=InoueMadoka en-aut-sei=Inoue en-aut-mei=Madoka kn-aut-name=井上円加 kn-aut-sei=井上 kn-aut-mei=円加 aut-affil-num=2 ORCID= en-aut-name=OzawaMasatugu en-aut-sei=Ozawa en-aut-mei=Masatugu kn-aut-name=小澤正嗣 kn-aut-sei=小澤 kn-aut-mei=正嗣 aut-affil-num=3 ORCID= en-aut-name=KanazawaTomoko en-aut-sei=Kanazawa en-aut-mei=Tomoko kn-aut-name=金澤智子 kn-aut-sei=金澤 kn-aut-mei=智子 aut-affil-num=4 ORCID= en-aut-name=SaitouTaiichi en-aut-sei=Saitou en-aut-mei=Taiichi kn-aut-name=斎藤太一 kn-aut-sei=斎藤 kn-aut-mei=太一 aut-affil-num=5 ORCID= en-aut-name=NakaharaRyuichi en-aut-sei=Nakahara en-aut-mei=Ryuichi kn-aut-name=中原龍一 kn-aut-sei=中原 kn-aut-mei=龍一 aut-affil-num=6 ORCID= en-aut-name=NodaTomoyuki en-aut-sei=Noda en-aut-mei=Tomoyuki kn-aut-name=野田知之 kn-aut-sei=野田 kn-aut-mei=知之 aut-affil-num=7 ORCID= en-aut-name=NishidaKeiichiro en-aut-sei=Nishida en-aut-mei=Keiichiro kn-aut-name=西田圭一郎 kn-aut-sei=西田 kn-aut-mei=圭一郎 aut-affil-num=8 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name=尾﨑敏文 kn-aut-sei=尾﨑 kn-aut-mei=敏文 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　整形外科 affil-num=2 en-affil= kn-affil=岡山大学病院　整形外科 affil-num=3 en-affil= kn-affil=岡山大学病院　整形外科 affil-num=4 en-affil= kn-affil=岡山大学病院　整形外科 affil-num=5 en-affil= kn-affil=岡山大学病院　整形外科 affil-num=6 en-affil= kn-affil=岡山大学病院　整形外科 affil-num=7 en-affil= kn-affil=岡山大学病院　整形外科 affil-num=8 en-affil= kn-affil=岡山大学病院　整形外科 affil-num=9 en-affil= kn-affil=岡山大学病院　整形外科 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=2 article-no= start-page=103 end-page=109 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Radiosensitization by telomerase-dependent oncolytic adenovirus kn-title=テロメラーゼ依存的腫瘍融解アデノウイルス製剤による 放射線感受性増強作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=DNA修復機能阻害は放射線感受性を増強させるため，DNA修復に関与する因子の阻害剤は放射線増感剤となり得る．我々の開発したテロメラーゼ依存的腫瘍融解アデノウイルス製剤OBP-301（テロメライシン）は，アデノウイルスE1B55kDaタンパクを介して細胞のDNA修復に重要な役割を果たすMRN複合体（Mre11，Rad50，NBS1）を分解する機能を有する．このMRN複合体の分解によりATM（ataxia-telangiectasia mutated）の活性化が抑制され結果的にDNA修復機構が阻害される．我々はOBP-301と放射線との併用が強力な相乗効果を生み出すことをマウスの皮下腫瘍モデルおよび食道癌同所性モデルにおいて証明した．これらの結果はOBP-301が将来有望な放射線増感剤となり得ることだけでなく，E1B55kDaタンパクを産生する腫瘍融解アデノウイルス製剤と放射線との併用が悪性腫瘍に対する有力な治療戦略となり得ることを示す． en-copyright= kn-copyright= en-aut-name=KurodaShinji en-aut-sei=Kuroda en-aut-mei=Shinji kn-aut-name=黒田新士 kn-aut-sei=黒田 kn-aut-mei=新士 aut-affil-num=1 ORCID= en-aut-name=FujiwaraToshiya en-aut-sei=Fujiwara en-aut-mei=Toshiya kn-aut-name=藤原俊哉 kn-aut-sei=藤原 kn-aut-mei=俊哉 aut-affil-num=2 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name=白川靖博 kn-aut-sei=白川 kn-aut-mei=靖博 aut-affil-num=3 ORCID= en-aut-name=YamasakiYasumoto en-aut-sei=Yamasaki en-aut-mei=Yasumoto kn-aut-name=山崎泰源 kn-aut-sei=山崎 kn-aut-mei=泰源 aut-affil-num=4 ORCID= en-aut-name=YanoSyuya en-aut-sei=Yano en-aut-mei=Syuya kn-aut-name=矢野修也 kn-aut-sei=矢野 kn-aut-mei=修也 aut-affil-num=5 ORCID= en-aut-name=UnoFutoshi en-aut-sei=Uno en-aut-mei=Futoshi kn-aut-name=宇野太 kn-aut-sei=宇野 kn-aut-mei=太 aut-affil-num=6 ORCID= en-aut-name=TazawaHiroshi en-aut-sei=Tazawa en-aut-mei=Hiroshi kn-aut-name=田澤大 kn-aut-sei=田澤 kn-aut-mei=大 aut-affil-num=7 ORCID= en-aut-name=HashimotoYuuri en-aut-sei=Hashimoto en-aut-mei=Yuuri kn-aut-name=橋本悠里 kn-aut-sei=橋本 kn-aut-mei=悠里 aut-affil-num=8 ORCID= en-aut-name=WatanabeYuichi en-aut-sei=Watanabe en-aut-mei=Yuichi kn-aut-name=渡辺雄一 kn-aut-sei=渡辺 kn-aut-mei=雄一 aut-affil-num=9 ORCID= en-aut-name=NomaKazuhiro en-aut-sei=Noma en-aut-mei=Kazuhiro kn-aut-name=野間和広 kn-aut-sei=野間 kn-aut-mei=和広 aut-affil-num=10 ORCID= en-aut-name=UrataYasuo en-aut-sei=Urata en-aut-mei=Yasuo kn-aut-name=浦田泰生 kn-aut-sei=浦田 kn-aut-mei=泰生 aut-affil-num=11 ORCID= en-aut-name=KagawaShunsuke en-aut-sei=Kagawa en-aut-mei=Shunsuke kn-aut-name=香川俊輔 kn-aut-sei=香川 kn-aut-mei=俊輔 aut-affil-num=12 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=7 en-affil= kn-affil=岡山大学病院　遺伝子・細胞治療センター affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=11 en-affil= kn-affil=オンコリスバイオファーマ株式会社 affil-num=12 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=13 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 en-keyword=アデノウイルス kn-keyword=アデノウイルス en-keyword=E1B55kDa kn-keyword=E1B55kDa en-keyword=MRN複合体 kn-keyword=MRN複合体 en-keyword=DNA修復 kn-keyword=DNA修復 en-keyword=放射線感受性 kn-keyword=放射線感受性 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=1 article-no= start-page=39 end-page=43 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Investigation of laparoscopic therapy in 56 cases of duodenal ulcer perforation kn-title=成人先天性胆道拡張症の6例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report six patients with adult congenital biliary dilatation treated by surgery. Of the six cases, five were female and the patients' age at diagnosis ranged from 19 to 51 years old. By Todani's classification for bile duct dilatation, three were categorized as Ⅰa, one as Ⅰb, and two as Ⅳa. All six cases had anomalous arrangement of the pancreatobiliary duct. Resection of the cystic portion and hepaticojejunostomy (Roux-Y) were performed in all. After surgery, one patient classified as Ⅰa and one as Ⅳa had complications of cholangitis and intrahepatic stones. We removed the stones by the percutaneous transhepatic route with dilatation of the stenotic anastomosis, but cholangitis recurred in the Ⅳa patient. Although surgical resection of the cystic portion and reconstruction of biliary tract is considered to be a standard treatment for adult congenital biliary dilatation, this Ⅳa case had complications after surgical treatment. Thus short-term follow-up is necessary to prevent or diagnose stenotic anastomosis following the operation. en-copyright= kn-copyright= en-aut-name=TakashimaHirotoshi en-aut-sei=Takashima en-aut-mei=Hirotoshi kn-aut-name=高嶌寛年 kn-aut-sei=高嶌 kn-aut-mei=寛年 aut-affil-num=1 ORCID= en-aut-name=SasakiAkira en-aut-sei=Sasaki en-aut-mei=Akira kn-aut-name=佐々木明 kn-aut-sei=佐々木 kn-aut-mei=明 aut-affil-num=2 ORCID= en-aut-name=SasakiKaoru en-aut-sei=Sasaki en-aut-mei=Kaoru kn-aut-name=佐々木薫 kn-aut-sei=佐々木 kn-aut-mei=薫 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=医療法人社団曙会　佐々木外科病院 affil-num=2 en-affil= kn-affil=医療法人社団曙会　佐々木外科病院 affil-num=3 en-affil= kn-affil=医療法人社団曙会　佐々木外科病院 en-keyword=先天性胆道拡張症 (congenital biliary dilatation) kn-keyword=先天性胆道拡張症 (congenital biliary dilatation) en-keyword=膵胆管合流異常 (anomalous arrangement of pancreaticobiliary ducts) kn-keyword=膵胆管合流異常 (anomalous arrangement of pancreaticobiliary ducts) END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=1 article-no= start-page=33 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Investigation of laparoscopic therapy in 56 cases of duodenal ulcer perforation kn-title=十二指腸潰瘍穿孔に対する治療法の適応についての検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Although conservative therapy has been acceptable as the first-line therapy for duodenal ulcer (DU) perforations, surgical therapies are known to have certain advantages. We investigated the indications for laparoscopic (LS) or open surgery (OS) or conservative therapy (CoT) among 56 DU perforation cases over 5 years. Methods: 31 LSs, 22 OSs and 5 CoTs were analyzed for patient's physical and surgical factors and clinical course. Results: Mean age was 51.6. Male/female ratio was 49/9. Survival ratio was 98%. Although the hospital stay (10.9 vs 19.5 days) and analgesic administrations (1.9 vs 4.6 days) were significantly shorter in LS than OS, almost all OS patients were in serious condition as evidenced by longer waiting time before treatment, stronger pain, bigger hole of perforation, more ascites accumulation and higher morbidity of complications. Two cases of multisurgery were experienced in both LS and OS groups due to leakage of seam, abscess formation, relapsed ulcer or idiopathic intestinal perforation. LS is a therapy more widely usable and more beneficial than the other two. Conclusion: LS, a minimally invasive surgery for DU perforation, should be considered as a first-line standard therapy because of significant advantages such as shorter hospital stay. OS or CoT may be selected when appropriate. en-copyright= kn-copyright= en-aut-name=IshidoNobuhiro en-aut-sei=Ishido en-aut-mei=Nobuhiro kn-aut-name=石堂展宏 kn-aut-sei=石堂 kn-aut-mei=展宏 aut-affil-num=1 ORCID= en-aut-name=TamuraRyuji en-aut-sei=Tamura en-aut-mei=Ryuji kn-aut-name=田村竜二 kn-aut-sei=田村 kn-aut-mei=竜二 aut-affil-num=2 ORCID= en-aut-name=OkamotoTakahiro en-aut-sei=Okamoto en-aut-mei=Takahiro kn-aut-name=岡本貴大 kn-aut-sei=岡本 kn-aut-mei=貴大 aut-affil-num=3 ORCID= en-aut-name=KadowakiYoshihiko en-aut-sei=Kadowaki en-aut-mei=Yoshihiko kn-aut-name=門脇嘉彦 kn-aut-sei=門脇 kn-aut-mei=嘉彦 aut-affil-num=4 ORCID= en-aut-name=MoriTakashi en-aut-sei=Mori en-aut-mei=Takashi kn-aut-name=森隆 kn-aut-sei=森 kn-aut-mei=隆 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=神戸赤十字病院　外科 affil-num=2 en-affil= kn-affil=神戸赤十字病院　外科 affil-num=3 en-affil= kn-affil=神戸赤十字病院　外科 affil-num=4 en-affil= kn-affil=神戸赤十字病院　外科 affil-num=5 en-affil= kn-affil=神戸赤十字病院　外科 en-keyword=十二指腸潰瘍穿孔 (duodenal ulcer perforation) kn-keyword=十二指腸潰瘍穿孔 (duodenal ulcer perforation) en-keyword=腹腔鏡手術 (laparoscopic surgery) kn-keyword=腹腔鏡手術 (laparoscopic surgery) en-keyword=保存療法 (conservative therapy) kn-keyword=保存療法 (conservative therapy) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=2 article-no= start-page=193 end-page=200 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520229 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=外科領域に於ける血液プロトロンビンに関する臨牀的研究 第4篇 ビタミンK投与の血液プロトロンビン指数に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺章三 kn-aut-sei=渡辺 kn-aut-mei=章三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所外科 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=2 article-no= start-page=172 end-page=184 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520229 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=外科領域に於ける血液プロトロンビンに関する臨牀的研究 第二篇 2～3外科的疾患に於ける血液プロトロンビン指数に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺章三 kn-aut-sei=渡辺 kn-aut-mei=章三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所外科 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=2 article-no= start-page=165 end-page=171 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520229 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=外科領域に於ける血液プロトロンビンに関する臨牀的研究 第1篇 血液プロトロンビン測定に関する基礎的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺章三 kn-aut-sei=渡辺 kn-aut-mei=章三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所外科 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=3 article-no= start-page=737 end-page=743 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Statistical Study on Chorioepithelioma kn-title=悪性絨毛上皮腫の統計的観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Statistical studies were carried out on seventy eight in-patients with chorioepithelioma at the Gynecological Dept. of Okayama University Medical School during the period from 1945 to 1955. The following results were obtained. The frequency of chorioepithelioma cases was 0.5 per cent, of gynecological in-patients during the said period, and average ages of these in-patients were thirty five years. Cases caused by hydatidiform moles were 57, 69 per cent and by artificial abortions, which have been remarkably prevailing after the end of the last World War, formed 10.25 per cent, of these in-patients. As for the latency period, it was less than six months on 90.75 per cent of these in-patients. Further, the followings were observed that most of these in-patients presented the symptoms of anemia, and 92.75 per cent of them had abnormally big uterus and on 42.62 per cent of these in-patients, cystic swells in the ovaries were seen. Besides, 44.87 per cent of them were subjected to metastasis, particularly on their vaginas and lungs, and on the external genitals, cerebrum, abdomen and bladder in frequent order. Methods of treatment, applied on these in-patients, were as follows. Operation (total hysterectomy has been adopted in principle at this Dept): 39.74 per cent Combined method of operation and radiotherapy: 46.15 per cent Radiotherapy method: 11.53 per cent Chemotheraphy method: 2.56 per cent The prognosis of these in-patients, after the foresaid treatment, were as follows. Primary death during treatment: 15.28 per cent In-patients, concluded to be incurable at the time of leaving of this Dept: 7.67 per cent In-patients, favourably recovered: 26.92 per cent In-patients, recovered temporarily: 50.00 per cent en-copyright= kn-copyright= en-aut-name=WatanabeIchiro en-aut-sei=Watanabe en-aut-mei=Ichiro kn-aut-name=渡辺一郎 kn-aut-sei=渡辺 kn-aut-mei=一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産婦人科教室 END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue=1 article-no= start-page=1 end-page=26 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780720 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on the Formation of Contemporary Multiple Farming in Japan and its Implication kn-title=「現代複合経営」の成立条件とその意義について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeM. en-aut-sei=Watanabe en-aut-mei=M. kn-aut-name=渡辺基 kn-aut-sei=渡辺 kn-aut-mei=基 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学教養部 END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=3 article-no= start-page=87 end-page=121 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19831130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Development of the Labour Market in the Southern Industrial Areas and its Influence on the Changes of the Farming Systems and the Organizations of Agriculture in the Mountainous and IIilly Districts of Okayama Prefecture 〔II〕 kn-title=岡山県南工業地帯における労働市場の展開と中山間部農業の変貌〔II〕―農業のシステム化と農法問題― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeMotoi en-aut-sei=Watanabe en-aut-mei=Motoi kn-aut-name=渡辺基 kn-aut-sei=渡辺 kn-aut-mei=基 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=2 article-no= start-page=1 end-page=45 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19830910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Development of the Labour Market in the Soutern Industrial Areas and its Influence on the Changes of the Farming Systems and the Organizations of Agriculture in the Mountainous and Hilly District of Okayama Prefecture. 〔I〕 kn-title=岡山県南工業地帯における労働市場の展開と中山間部農業の変貌〔I〕―農業のシステム化と農法問題― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeMotoi en-aut-sei=Watanabe en-aut-mei=Motoi kn-aut-name=渡辺基 kn-aut-sei=渡辺 kn-aut-mei=基 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=3 article-no= start-page=179 end-page=187 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19841220 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=K. Shimono, Coal- Chemical Industry in Postwar Japan kn-title=下野克己著『戦後日本石炭化学工業史』への若干の問題提起 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeTokuji en-aut-sei=Watanabe en-aut-mei=Tokuji kn-aut-name=渡辺徳二 kn-aut-sei=渡辺 kn-aut-mei=徳二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=城西大学 END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=1 article-no= start-page=1 end-page=26 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840623 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Position and the Role of the Agricultural Cooperative Food Processing Industry in the National Food Production kn-title=国民食糧の生産と農協加工事業，その地位と役割 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeMotoi en-aut-sei=Watanabe en-aut-mei=Motoi kn-aut-name=渡辺基 kn-aut-sei=渡辺 kn-aut-mei=基 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=2 article-no= start-page=31 end-page=75 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=19870910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Trend of Business Carried on by Federations of Agricultural Cooperations A Comparative Case Study of Kagoshima and Yamaguchi kn-title=農協経済連事業の動向―鹿児島・山口を対比して― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeMotoi en-aut-sei=Watanabe en-aut-mei=Motoi kn-aut-name=渡辺基 kn-aut-sei=渡辺 kn-aut-mei=基 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue=4 article-no= start-page=267 end-page=302 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Relevance, Reflexibility and Context of the Cost Accounting System : A Viewpoint of Cost Accounting Change kn-title=原価計算システムの目的適合性，写像性，およびコンテクスト―原価計算システム変化論の視座― en-subtitle= kn-subtitle= en-abstract= kn-abstract=We have argued that cost accounting system should be modified in accordance with the purpose for using them and the context. Because no cost accounting system that is relevant in every business or environment exists. Relevant cost accounting system is determined in a particular environment and context. This mode of thought relates directly to proposition which develops to explain the theory of 'cost accounting change'. This paper examines the relationships among the purpose, reflexibility and contexts of cost accounting system. The analysis based on reflexibility theory and some previous studies for activity-based costing and contingency theory indicated that: 1) Actual reflexibility about existing cost accounting was associated with two contextual variables: product diversity and process complexity. 2) A reflexibility required mainly through the purpose for using cost accounting was associated with two contextual variables: competitive strategy and perceived environment uncertainty. Finally, we concluded that the relevance of cost accounting was lost and 'cost accounting change' became necessary when the level of actual reflexibility didn't fit that of required reflexibility. en-copyright= kn-copyright= en-aut-name=WatanabeTakeo en-aut-sei=Watanabe en-aut-mei=Takeo kn-aut-name=渡辺岳夫 kn-aut-sei=渡辺 kn-aut-mei=岳夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-2 article-no= start-page=6967 end-page=6975 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Quantitative Determination of Urobilin Body Part II Studies on the Aldehyde Reaction in Heating kn-title=Urobilin体の定量に関する研究 第2篇 加熱時のAldehyde反応 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1. The comparative studies were photometrically observed on the reacting solution after the aldehyde reaction of each proportion separated from urine by the Weiss's method at the room temperature or in heating and it was clarified, that the pigment occupied the important region of increasing the red tone was the II proportion of histidin and the origin of it's pigment was indican, by the paperchromatography. The substance of indole system was contained in the urochrom proportion and histidinel L proportion and it increased the red tone in heating, but the rate of increasing the color was low as compared with indican. 2. The combined substance of indoxyl-aldehyde i. e. Goessner's pigment became red in the polar solvent and yellowish brown in the unpolar solvent, and it changed to red over the pH 4 and yellowish brown below the pH 4. Therefore, it was yellowish brown with the absorption maximum at 474 mμ under the condition in the aldehyde reaction of urine, but it became having a red tone on the density of indican over 3mg dl. 3. The relation of urobilinogen was often observed on the red tone appeared at the first period, in heating after the addition of aldehyde reagent into urine. en-copyright= kn-copyright= en-aut-name=WatanabeHaruo en-aut-sei=Watanabe en-aut-mei=Haruo kn-aut-name=渡辺春生 kn-aut-sei=渡辺 kn-aut-mei=春生 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-2 article-no= start-page=6953 end-page=6965 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Quantitative Determination of Urobilin Body Part 1 Studies on the Quantitative Methods of Urobilin Body kn-title=Urobilin体の定量に関する研究 第1篇 Urobilin体定量法の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The Terwen's reduction method and the methods reported by Heilmeyer, Krebs and Watson were fully observed. And the results were as follows. 1. Urobilin was completely reduced to urobilinogen within 2 hours by the Terwen's method, and the highest uroblinogen value was observed on the mixed rate of the materials and the reducing agents in 40:5:5. The materials should be stored, under the isolation of air and light, at the low temperature as possible and there was a limitation for the preserved time. 2. The optimal range of pH for the extraction of urobilinogen into the solvont. 3. It was demonstrated that petroleum ether was the best solvent for the extraction of urobilinogen since the comparative studies on the various solvent, especially between ether and petroleum ether. 4. The composition of regent needed the concentration of 0.3% P-dimethylaminobenzaldehyde on the use of 60% hydrochloric acid and of 1% P-dimethylaminobenzaldehyde on the use of 50% hydrochloric acid. 5. The shaking process for one minute was needed till the addition of sodium acetate after the addition of regents, urobilinogen in the solvent was extracted into hydrochloric acid in the regent and the reaction was performed in the water layer by the above treatment. The progress of aldehyde reaction on this occasion was considerably quantitative. 6. The significance of adding sodium acetate was to shift to nearly the pH 4 after the terminal reaction and was to remove the coloration by indole body, with bringing the coloration of urobilinogen up to the highest and keeping the stability of it. 7. The influence of indole, indican, P.A.S. and sulfonamid derivatives shown the similar reaction in the qualitative test could be eliminated on the quantitive method. en-copyright= kn-copyright= en-aut-name=WatanabeHaruo en-aut-sei=Watanabe en-aut-mei=Haruo kn-aut-name=渡辺春生 kn-aut-sei=渡辺 kn-aut-mei=春生 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=9-2 article-no= start-page=5911 end-page=5920 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Acatalasemia from the Viewpoint of Oral Surgery I. Exfoliative Cytology kn-title=無カタラーゼ血液症における歯科学的研究 I. 剥離細胞学的検索 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Exfoliative cytologic findings of the oral mucosa in three cases of Acatalasemia (Takahara's disease) were investigated by means of Papanicolaou's method. Three cases were sisters of the same family, 19, 22, and 15 years of age. Oroantral fistula was noticed in the left molar area in Case 2 and Case 3 complained of loosening of anterior lower teeth with marginal gingivitis in the left lower molar ares. Smears were prepared by the following technics: 1) Scraping four different areas of the oral mucosa---hard palate, gingiva, radix linguae and buccal mucosa without causing bleeding. 2) Sediment taken from centrifuged mouth washings by physiologic saline solution. 3) Cells caught by membrane filter or both of them. All the smears were stained by Papanicolaou's technic and histologic examination of the gingiva was made in comparison with cytologic smears in Case 3. Thus keratinization of the epithelial cells were studied. 1) Keratinizing tendency was the same as those of normal mucosa in Cases 1 and 3. In the ulcerating area of Case 3 keratinized cells showed an increase as healing was going on, while they showed a marked decrease in Case 2, which might be due to the decrease of local resitance associated with ulcerative changes and the influence of partial denture. 2) Exfoliated cells of the whole oral mucosa in case of mouth washings Cases 1 and 3 showed the same findings as normal cases and Case 2 showed a marked decrease of keratinized cells. These findings were same as those of four different areas of the oral mucosa. 3) Gingiva of Case 3 showed little difference from normal mucosa in histopathologic findings. en-copyright= kn-copyright= en-aut-name=WatanabeYoshio en-aut-sei=Watanabe en-aut-mei=Yoshio kn-aut-name=渡辺義男 kn-aut-sei=渡辺 kn-aut-mei=義男 aut-affil-num=1 ORCID= en-aut-name=MatsuiToshiyuki en-aut-sei=Matsui en-aut-mei=Toshiyuki kn-aut-name=松井儇行 kn-aut-sei=松井 kn-aut-mei=儇行 aut-affil-num=2 ORCID= en-aut-name=ShiraishiYoshio en-aut-sei=Shiraishi en-aut-mei=Yoshio kn-aut-name=白石好夫 kn-aut-sei=白石 kn-aut-mei=好夫 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部歯科口腔外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部歯科口腔外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部歯科口腔外科学教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=7-2 article-no= start-page=4479 end-page=4485 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590710 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Enzymatic Properties of Freezing-dried Cells Part II Staphy. aureus and albus kn-title=凍結乾燥菌の酵素的性状について 第2編 Staphy. aureus, albus en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using the standard strains of Staphy. aureus and albus stocked in author's department, the author carried out the investigations just in same way as preceeding paper (Part I). The results obtained are following. 1) The freezing-dried cells of both strains showed increased permeability to inhibitors, namely, KCN, NaN(3), NaF, and HXA, compared with the fresh cells of these bacteria. 2) The oxydation of succinate by the freezing-dried cells of both strains were not inhibited in the presence of malonate, while that oxydation by Sal. typhi was inhibited. 3) The oxydation capacity for pyruvate were markedly decreased on the freezing-dried cells of both strains. 4) In the sight of stoichiometrical studies, it could be postulated that the oxydative degradation of glucose by freezing-dried cells of Staphy. aureus might be carried out mainly through the Embden-Myerhof's pathway; and the Warburg-Dickens' shunt was also supposed to be present in the fresh cells of that bacteria. The other pathway for the degradation was thought to be exist in Staphy. albus in either case, fresh or freezing-dried. en-copyright= kn-copyright= en-aut-name=WatanabeSyunsuke en-aut-sei=Watanabe en-aut-mei=Syunsuke kn-aut-name=渡辺俊介 kn-aut-sei=渡辺 kn-aut-mei=俊介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=7-2 article-no= start-page=4471 end-page=4478 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590710 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Enzymatic Properties of Freezing-dried Cells Part I Sal. typhi 57 S and R kn-title=凍結乾燥菌の酵素的性状について 第1編 Sal. typhi 57S, R en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using the standard strains of Sal. typhi 57 S and R taken from the departmental stock, the author investigated the effects of freezing-drying treatment of bacteria on the specificity of their substrates, the permeability of inhibitors, and the properties of enzyme system, and also observed the differences in enzymatic properties of two strains. The following results were obtained. 1) It was observed the increased permeability of the surface of cells treated by freezing-drying method to inhibitors; NaN3, NaF and HXA. 2) Both strains of bacteria tested could not oxydize gluconate and citrate in fresh state, whil the freezing-dried cells of Sal. typhi 57 R could that in some extent. 3) There was marked decrease of the oxydation capacity for pyruvate by the freezing-dried cells of both strains. 4) From the viewpoint of stoichiometrical studies, it could posturate the presence of different pathway for the degradation of glucose besides Embden-Myerhof's pathway, presumably Warburg-Dicken's shunt, in the fresh cells of Sal. typhi 57 R. But in the freezing-dried cells of both strains the degradation might be carried out through Embden-Myerhof's pathway. en-copyright= kn-copyright= en-aut-name=WatanabeSyunsuke en-aut-sei=Watanabe en-aut-mei=Syunsuke kn-aut-name=渡辺俊介 kn-aut-sei=渡辺 kn-aut-mei=俊介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=101 cd-vols= no-issue=11-12 article-no= start-page=977 end-page=989 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies of guanidinoethanesulfonic acid induced convulsions - Effect of guanidinoethanesulfonic acid on monoamines in the mouse brain - kn-title=Guanidinoethanesulfonic acid誘発痙攣に関する研究―特に脳内モノアミンにおよぼす影響― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Guanidinoethanesulfonic acid (GES) is known to induce convulsive seizures when administered intracisternally into rabbits and cats. I examined the effects of GES on behavior, electroencephalogram and brain monoamine levels after intraventricular injection into mice. When GES was intraventricularly injected into mice, focal clonic movements of the face, vibrissae and ears, as well as twitchings of limbs were observed 0.5-1 min after injection. Hypersensitivity was observed until 7 min after the injection, after which the mice behaved in a normal way. It is also observed that GES induced sporadic spike discharges in the electroencephalogram. The latency and duration of the appearence of spike discharges showed considerable individual variation. The latency was from 0 to 5 min, and the duration was from 5 to 90 min. No spike discharge was observed in the saline injected animals. The 5-hydroxytryptamine (5-HT) level decreased in the hippocampus, diencephalon, pons-medulla oblongata and cerebellum 5 min after injection, and recovered to the control level 10 min after the injection. No change in the norepinephrine (NE) and dopamine (DA) levels was found after GES injection. 5-hydroxyindoleacetic acid increased in the striatum and cerebellum 5 min after injection. It is thought that the GES injection enhances the release of 5-HT in the striatum and cerebellum, although the mechanism of the decrease of 5-HT in the hippocampus, diencephalon and pons-medulla oblongata is unclear. These results indicate that the GES induced convulsive seizure is related to 5-HT neurons, not NE or DA neurons. en-copyright= kn-copyright= en-aut-name=WatanabeShunji en-aut-sei=Watanabe en-aut-mei=Shunji kn-aut-name=渡辺駿二 kn-aut-sei=渡辺 kn-aut-mei=駿二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳代謝研究施設機能生化学部門教室 en-keyword=guanidinoethanesulfonic acid kn-keyword=guanidinoethanesulfonic acid en-keyword=convulsion kn-keyword=convulsion en-keyword=brain monoamines kn-keyword=brain monoamines en-keyword=5-hydroxytryptamine kn-keyword=5-hydroxytryptamine END start-ver=1.4 cd-journal=joma no-vol=101 cd-vols= no-issue=5-6 article-no= start-page=487 end-page=494 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Echocardiography in congenital pericardial defect - Alterations of cardiac motion induced by posture changes - kn-title=先天性心膜欠損症における心臓超音波所見（体位変換による所見の変化） en-subtitle= kn-subtitle= en-abstract= kn-abstract=The true incidence of congenital pericardial defects is unknown, but it is more common than generally supposed. Because of the variance of chest X-rays, ECG and symptoms according to the degree of the defect, it is still not easy to diagnose a pericardial defect. Recently, we experienced four patients with congenital pericardial defects. Three cases were absence of the left pericardium and one was an absence of the right. In these patients, the view with echocardiography was characteristically altered by posture changes. All three patients with left-sided defect showed an enlarged right ventricular cavity, paradoxycal motion of the interventricular septum and hyperkinetic motion of the posterior wall in the left lateral decubitus position. These findings were not present in the right decubitus position. On the other hand, in a case with a right-sided defect, the view was almost normal in the left decubitus position. In the right decubitus position, the right ventricular cavity enlarged and the interventricular septum moved hyperkineticaly. These alterations of echocardiographic findings by posture changes were specific to the side of the pericardial defect, and were caused by a change in cardiac restraint. Therefore, an echocardiogram recorded with posture changes is useful in the diagnosis of congenital pericardial defects. en-copyright= kn-copyright= en-aut-name=HinaKazuyoshi en-aut-sei=Hina en-aut-mei=Kazuyoshi kn-aut-name=日名一誠 kn-aut-sei=日名 kn-aut-mei=一誠 aut-affil-num=1 ORCID= en-aut-name=UeedaMasayuki en-aut-sei=Ueeda en-aut-mei=Masayuki kn-aut-name=上枝正幸 kn-aut-sei=上枝 kn-aut-mei=正幸 aut-affil-num=2 ORCID= en-aut-name=UchidaShinji en-aut-sei=Uchida en-aut-mei=Shinji kn-aut-name=内田真司 kn-aut-sei=内田 kn-aut-mei=真司 aut-affil-num=3 ORCID= en-aut-name=HasuiMasahiro en-aut-sei=Hasui en-aut-mei=Masahiro kn-aut-name=蓮井雅浩 kn-aut-sei=蓮井 kn-aut-mei=雅浩 aut-affil-num=4 ORCID= en-aut-name=MimaTsutomu en-aut-sei=Mima en-aut-mei=Tsutomu kn-aut-name=美馬敦 kn-aut-sei=美馬 kn-aut-mei=敦 aut-affil-num=5 ORCID= en-aut-name=WatanabeHirofumi en-aut-sei=Watanabe en-aut-mei=Hirofumi kn-aut-name=渡辺博史 kn-aut-sei=渡辺 kn-aut-mei=博史 aut-affil-num=6 ORCID= en-aut-name=SaitoDaiji en-aut-sei=Saito en-aut-mei=Daiji kn-aut-name=斉藤大治 kn-aut-sei=斉藤 kn-aut-mei=大治 aut-affil-num=7 ORCID= en-aut-name=TsujiTakao en-aut-sei=Tsuji en-aut-mei=Takao kn-aut-name=辻孝夫 kn-aut-sei=辻 kn-aut-mei=孝夫 aut-affil-num=8 ORCID= en-aut-name=MatubaraKatashi en-aut-sei=Matubara en-aut-mei=Katashi kn-aut-name=松原堅 kn-aut-sei=松原 kn-aut-mei=堅 aut-affil-num=9 ORCID= en-aut-name=YoshidaHidenori en-aut-sei=Yoshida en-aut-mei=Hidenori kn-aut-name=吉田英紀 kn-aut-sei=吉田 kn-aut-mei=英紀 aut-affil-num=10 ORCID= en-aut-name=HaraokaShoichi en-aut-sei=Haraoka en-aut-mei=Shoichi kn-aut-name=原岡昭一 kn-aut-sei=原岡 kn-aut-mei=昭一 aut-affil-num=11 ORCID= en-aut-name=IwasakiKohichiro en-aut-sei=Iwasaki en-aut-mei=Kohichiro kn-aut-name=岩崎孝一郎 kn-aut-sei=岩崎 kn-aut-mei=孝一郎 aut-affil-num=12 ORCID= en-aut-name=KusachiShozo en-aut-sei=Kusachi en-aut-mei=Shozo kn-aut-name=草地省蔵 kn-aut-sei=草地 kn-aut-mei=省蔵 aut-affil-num=13 ORCID= en-aut-name=KitaToshimasa en-aut-sei=Kita en-aut-mei=Toshimasa kn-aut-name=喜多利正 kn-aut-sei=喜多 kn-aut-mei=利正 aut-affil-num=14 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学教室 affil-num=12 en-affil= kn-affil=心臓病センター榊原病院 affil-num=13 en-affil= kn-affil=心臓病センター榊原病院 affil-num=14 en-affil= kn-affil=心臓病センター榊原病院 en-keyword=心膜欠損症 kn-keyword=心膜欠損症 en-keyword=心臓超音波 kn-keyword=心臓超音波 en-keyword=心室中隔奇異性運動 kn-keyword=心室中隔奇異性運動 END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue= article-no= start-page=52 end-page=56 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=195709 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=花崗岩に関する諸問題　（9）　日本の花崗岩と鉱床との関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡辺武男 kn-aut-sei=渡辺 kn-aut-mei=武男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=東京大学理学部地質学教室 END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue= article-no= start-page=7 end-page=19 dt-received= dt-revised= dt-accepted= dt-pub-year=1961 dt-pub=19610625 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on the Separation of Uranium by Ion Exchage kn-title=陰イオン交換樹脂によるウランの分離に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=UmemotoShunji en-aut-sei=Umemoto en-aut-mei=Shunji kn-aut-name=梅本春次 kn-aut-sei=梅本 kn-aut-mei=春次 aut-affil-num=1 ORCID= en-aut-name=SakanoueMasanobu en-aut-sei=Sakanoue en-aut-mei=Masanobu kn-aut-name=渡辺昌介 kn-aut-sei=渡辺 kn-aut-mei=昌介 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所化学部門 affil-num=2 en-affil= kn-affil=岡山大学温泉研究所 END start-ver=1.4 cd-journal=joma no-vol=36 cd-vols= no-issue= article-no= start-page=23 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=1966 dt-pub=19661025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Minor elements of the Nanbu Kotai of Nakatsugo Deposits, Ningyo Toge Uranium Mine kn-title=人形峠ウラン鉱山，中津河鉱床南部鉱体の微量元素について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The Nakatsugo Deposits are the main deposits of the Ningyo Toge Mine which is located in the northern part of Okayama Prefecture. Nakatsugo Deposits consists of the two main ore body, namely, Nanbu Kotai (southern ore body) and Hon Kotai (main ore body). Nanbu Kotai is occupied mostly by the unoxidized zone and high grade ores containing ningyoite (n% U) are widely found in the basal conglomerates. Minor elements in the common rocks such as basal granites, conglomerates, sandstones, dikes, and shales as well as the uraniferous ores were determined quantatively by fluorescent X-ray spectrometric analysis (for U, Zr, Y, Sr, As, and Fe) and spectrophotometric analysis (for Ni and Co). As the results of this study, it is found that the uraniferous ores are characterised by extremely high contents of Zr, Y, Sr, and As, which show positive and linear correlation with the U contents. It is confirmed that As is concentrated in pyrite which is usually associated with the uraniferous ores. Elements such as Ni and Co are slightly concentrated both in the uraniferous ores and andesite dikes. This fact may suggest some genetic relationship among them. However, it does not seem to be plausible to draw any definite conclusion on the origin of the uranium deposits from these relationships. As to the minor element distribution in common rocks, no systematic variation was found except for the rock samples closely associated with the ore deposits. en-copyright= kn-copyright= en-aut-name=WatanabeKoji en-aut-sei=Watanabe en-aut-mei=Koji kn-aut-name=渡辺晃二 kn-aut-sei=渡辺 kn-aut-mei=晃二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所地質学部門 END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue= article-no= start-page=9 end-page=12 dt-received= dt-revised= dt-accepted= dt-pub-year=1972 dt-pub=19720325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the measurement of oxygen and carbon isotopic ratios of carbonates kn-title=炭酸塩の酸素および炭素同位体比の測定について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Oxygen and carbon isotopic ratios of two working standards of our laboratory and three other standards were measured by McCrea's technique and the new McKINNEY type mass spectrometer in this Institute. The reproducibility of δ(13)C measurement is about ±0.2‰. Some systematic differences in δ(18)O values were observed among the three measurements in Apr.-May, July, and Aug., 1971. Because these systematic differences are supposed to be caused by the imperfection in the processes of decomposition of carbonates by phosphoric acid, the reproducibility of δ(18)O measurement may be ±O.2‰ in most cases. The calibrations of our working standard, CK-13, against the PDB standard were carried out on the assumption that δ(18)O and δ(13)C of CK-13 are -1.75‰ and +O.54‰ relative to PDB, respectively. The accuracy of these calibrations is about ±O.2‰ as shown by the interlaboratory comparison of some standards (Table 3). The δ(18)O values of the two working standards relative to PDB are independently recalculated relative to SMOW based on the two assumptions (Table 4). One of which is that a standard water MSA-2 is -8.20‰ relative to SMOW, and the other is that the δ(18)O of CK-13 is -1.75‰ relative to PDB. The results of both calculations agree within 0.4‰. en-copyright= kn-copyright= en-aut-name=WatanabeMakoto en-aut-sei=Watanabe en-aut-mei=Makoto kn-aut-name=渡辺洵 kn-aut-sei=渡辺 kn-aut-mei=洵 aut-affil-num=1 ORCID= en-aut-name=MatsubayaOsamu en-aut-sei=Matsubaya en-aut-mei=Osamu kn-aut-name=松葉谷治 kn-aut-sei=松葉谷 kn-aut-mei=治 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=東京大学理学部地質学教室 affil-num=2 en-affil= kn-affil=岡山大学温泉研究所温泉化学部門 END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=2 article-no= start-page=175 end-page=176 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=西宮渡辺病院 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=佐々木恭子 kn-aut-sei=佐々木 kn-aut-mei=恭子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=西宮渡辺病院 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=歯科臨床における感染予防対策意識と行動についての現状と課題　－某県歯科衛生士会会員に対する意識調査から－ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeAkari en-aut-sei=Watanabe en-aut-mei=Akari kn-aut-name=渡辺朱理 kn-aut-sei=渡辺 kn-aut-mei=朱理 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=53 end-page=62 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19641025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Determination of Dissolved Gases in the Ground Water at Mt. Daisen kn-title=大山の地下水の溶存ガスの定量 en-subtitle= kn-subtitle= en-abstract=The contents of the dissolved gases in the ground waters at the north west of the piedmont district of Daisen volcano, Tottori prefecture, are determined as follows. Ar: 0.34～0.40 (cc/l) 1.48～1.64 (%) O(2) : 6.69～9.08 (cc/l) 27.92～35.30 (%) N(2) : 15.16～17.23 (cc/l) 63.22～67.92 (%) The calculated degree of saturation of these ground waters with O(2) and N ranges as shown below : O(2) : 87.8～113.9 (%) N(2) : 110.5～123.2 (%) In this district, the ground water is generally of a shallow type. The degree of oxygen consumption of the water has a tendency to decrease as its pass under the ground is shorter. From the results obtained here, it is concluded that these ground water have intermediate properties of the surface and general ground water. kn-abstract=鳥取県大山火山の西北麓の地下水中に潜存するガス成分比は Ar : 0.34～0.40 (cc/l) 1.48～1.64 (%) O(2) : 6.69～9.08 (cc/l) 27.92～35.30 (%) N(2) : 15.16～17.23 (cc/l) 63.22～67.92 (%) の範囲内で定量できる.また,飽和度は次の如くである. O(2) : 87.8～113.9 (%) N(2) : 110.5～123.2 (%) この結果を地表水と比較して,O(2)の飽和度は小さいが,量的な差異はあまりみられず,地表水と地下水の中間的な性質を示している.地質構造,地形が溶存ガス成分比に及ぼす影響は,地下水の流通経路が長距離とみなされる場合に若干のO(2)の消費が認められ,短距離で湧出したと思われるものにはO(2)の飽和度が大きい傾向がある.また,水理地質的にみて,地質と湧出量には密接な関連を見出せるが,ガス成分には影響を与へてはいない. en-copyright= kn-copyright= en-aut-name=WatanabeKoji en-aut-sei=Watanabe en-aut-mei=Koji kn-aut-name=渡辺晃二 kn-aut-sei=渡辺 kn-aut-mei=晃二 aut-affil-num=1 ORCID= en-aut-name=OkunoTakaharu en-aut-sei=Okuno en-aut-mei=Takaharu kn-aut-name=奥野孝晴 kn-aut-sei=奥野 kn-aut-mei=孝晴 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所地質学部門 affil-num=2 en-affil= kn-affil=岡山大学温泉研究所 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=41 end-page=52 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19641025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Mineral Composition of Boring Core at Tottori Hot Spring kn-title=鳥取温泉におけるボーリング･コアの組成鉱物について en-subtitle= kn-subtitle= en-abstract=The boring coreS of Tottori Hot Spring, Tottori city were investigated by means of X-ray powder method and differential thermal analysis. Near this district, the Quarternary sediments are perceived until at a depth of 54 meters, and they show some striking differences from the Tertiary sediments which lies under-neath the former. In the Quarternary sediments, small amounts of chlorite coexist with ilIte. Kaolinite is found only in the top soil, and montmorillonite is present just above the unconformity with the Tertiary sediments. The clays from the Tertiary sediments contain abundant amounts of chlorite that exibits regional propylitization. The amounts of the rock forming minerals, quartz and feldspars, in these sediments regularly decrease with increasing amounts of clay minerals. The pH of the thermal water at the pit bottom ranges from 7 to 8, and the maximum water temperature, 57.2℃, is observed. The secondary minerals, montmorillonite and calcite, are thought to be the alteration products by the thermal water. kn-abstract=鳥取温泉の深度300mに及ぶ試錐のボーリング･コアを検討した結果,主成分鉱物として,石英,長石類(斜長石,加里長石,)と二次的生成鉱物としてモンモリロナイト,カオリナイト,イライト,緑泥石,黄鉄鉱などを認めた.このうち,イライトは堆積岩中に普遍的に存在し,更に緑泥石も全般的にしかも第三紀層で多量に認められている.モンモリロナイトは方解石と共に温泉による生成が考へられ,また,カオリナイトは表土層にのみ認める事ができる.一方,加里長石,黄鉄鉱,緑泥石の産出状態,及びコアが示す粒度,酸化状態からして第四紀層の堆積環境が推定され,25mを境として下部は数回の陸化を含む浅い堆積層であるのに対し,上部は比較的深い.背後供給地から離れた海成層を示唆する. en-copyright= kn-copyright= en-aut-name=WatanabeKoji en-aut-sei=Watanabe en-aut-mei=Koji kn-aut-name=渡辺晃二 kn-aut-sei=渡辺 kn-aut-mei=晃二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所地質学部門 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=21 end-page=40 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19641025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Bed Rock and Wall Rock Alteration of the Uranium Deposits at the Togo Mine, Tottori Prefecture (1) Katamo and Asabatake Deposits kn-title=鳥取県東郷鉱山ウラン鉱床の基盤岩ならびに母岩の変質 (1)方面･麻畑鉱床 en-subtitle= kn-subtitle= en-abstract=The Katamo and Asabatake Uranium Deposits, Togo Mine, about 5 Km south east of the lake Togo, central Tottori prefecture, is investigated to understand the nature of the bed rock and wall rock alterations. These alterations are remarkable and characterized as follows. (1) Both the clay mineral species and their relative amounts are closely related to the "oxidation-reduction enviroment" of the deposits. (2) The degree of alteration depends on the nature of the mother rocks and differs from an area to another. The most remarkable alteration is realized in the secondary oxidation zone. (3) Although the secondary uranium minerals are confined in the oxidation zone, there is no apparent relationship between the total amounts of clay minerals and uranium contents of the deposits. But the amounts of montmorillonite seems to decrease as uranium content goes up within some limited areas. The principal clay mineral in the deposits is montmorillonite. Kaolinite is also present in a small amount. Sericite is found only in some of the veins as an accessory mineral. Hydrothermal solutions seems to have played an important role for the formation of montmorillonite, as it is found in a well crystallized form in altered acidic pyroclastic sediments. Kaolinite, on the other hand, has a tendency to increase in its amount in arkose sediments which are sandwiched in volcanic sediments. This seems to show that kaolinite is a weathered product of the bed rocks of this region. The results presented in this paper could be a help in considering the origin of the Uranium deposits in this area. kn-abstract=東郷鉱山,方面･麻畑ウラン鉱床の基盤岩および母岩は粘土化が著しく,その特徴として次のことが挙げられる. (a)粘土鉱物の種類,存在量は,鉱床の酸化帯･非酸化帯にはゞ規制されている.(b)粘土化の程度は原岩の種類により異なり,同一種数の岩石では酸化帯における変質が特に顕著である.(c)粘土量とウラン含有量との間には明確な相関は見出せないが,モンモリロナイトの量についてのみ観察すると,おおよそ負の相関がみられる.また,粘土化の主体をなすモンモリロナイトは,結晶度が良好で熱水変質が示唆きれる.化学分析の結果,SiO(2)の量が少ないので珪ばん比が異常に小さいが,ウラン鉱床近辺においてモンモリロナイト化に伴なう珪化帯が認められず,珪酸の逸脱が考えられる.鉱量的にみて,両鉱床の主体をなすウラン鉱物が燐顧塩鉱物であり,珪酸塩鉱物が少ないことなどから,モンモリロナイト化作用と鉱化作用との間には,直接関連がないものと考察される. en-copyright= kn-copyright= en-aut-name=WatanabeKoji en-aut-sei=Watanabe en-aut-mei=Koji kn-aut-name=渡辺晃二 kn-aut-sei=渡辺 kn-aut-mei=晃二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所地質学部門 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=1 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19641025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Radioactive Anomaly in the Okutsu Kaoline Mine, Okayama Prefecture kn-title=岡山県奥津カオリン鉱床の放射能異常 en-subtitle= kn-subtitle= en-abstract=The Okutsu Kaolin Mine. producing about 450 tons of clay a month, is located 25 Km north of Tsuyama, northern Okayama Prefecture. The massive hydrothermal clay deposits, present in granodiorite, is vertical1y and horizontally zoned. A white clay core, hal10ysite and hydrated halloysite, is surrounded by a laumontite-quartz zone. A epidote-quartz zone comes next and the outermost is a slightly altered granodiorite associated with epidote. The epidote-quartz zone is usually of radioactivity which is due to minor amounts of a reddish brown amorphous mineral, containg thorium. However, Uranium has never been detected in materials from the radioactive zone. The other zones are normal or low radioactivity. During hydrothermal alteration, the granodiorite changed to clay deposits and all the original components except Al(2)O(3) and TiO(2) were leached out. The leached CaO and Fe(2)O(3) were repricipitated around the deposits forming the epidote-quartz zone. The leached thorium behaved similarly with the two elements and waS concentrated together with them. The concept of the concentration of thorium discussed in this paper may help in solving questions on the alteration of the basal granite and the origin of radioactive elements in the neighbouring Ningyo Toge Uranium Fields. kn-abstract=奥津カオリン鉱床は花崗緑岩中の熱水交代性の塊状粘土鉱床であって, 中心部に白色粘土鉱体, それをとりまいて石英沸石帯,更にその外側に緑簾石帯からなる変質の帯状分布が存在する. 放射能異常は外側変質帯の緑簾石帯に集中しており, そこにトリウムの濃集が認められる. 本鉱床の放射性元素の濃集は変質帯形成の機構と密接に関連するものとみられる. en-copyright= kn-copyright= en-aut-name=OkunoTakahara en-aut-sei=Okuno en-aut-mei=Takahara kn-aut-name=奥野孝晴 kn-aut-sei=奥野 kn-aut-mei=孝晴 aut-affil-num=1 ORCID= en-aut-name=WatanabeKoji en-aut-sei=Watanabe en-aut-mei=Koji kn-aut-name=渡辺晃二 kn-aut-sei=渡辺 kn-aut-mei=晃二 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所 affil-num=2 en-affil= kn-affil=岡山大学温泉研究所地質学部門 END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=10 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198707 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=グッピー集団の一過性過剰移動 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeMunetaka en-aut-sei=Watanabe en-aut-mei=Munetaka kn-aut-name=渡辺宗孝 kn-aut-sei=渡辺 kn-aut-mei=宗孝 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学教養部生物学教室 END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue= article-no= start-page=25 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=200308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of polymeric biodegradability based on experimental results and numerical simulation kn-title=実験結果と数値シミュレーションによるポリマー生分解性解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We describe techniques that we developed previously in studies of biodegradation of polymeric compounds. We present some experimental results concerning biodegradation of polyethylene. We introduce a mathematical model that govern the evolution of the weight distribution, and show how its inverse problem can be analyzed. We also introduce a mathematical model that governs the evolution of the weight distribution of polymeric compound subjected to enzymatic degradation, and present some numerical results concerning enzymatic degradation of polyvinyl alcohol. en-copyright= kn-copyright= en-aut-name=WatanabeMasaji en-aut-sei=Watanabe en-aut-mei=Masaji kn-aut-name=渡辺雅二 kn-aut-sei=渡辺 kn-aut-mei=雅二 aut-affil-num=1 ORCID= en-aut-name=KawaiFusako en-aut-sei=Kawai en-aut-mei=Fusako kn-aut-name=河合富佐子 kn-aut-sei=河合 kn-aut-mei=富佐子 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学環境理工学部環境数理学科 affil-num=2 en-affil= kn-affil=岡山大学資源生物科学研究所 en-keyword=biodegradation kn-keyword=biodegradation en-keyword=mathematical model kn-keyword=mathematical model en-keyword=numerical simulation kn-keyword=numerical simulation en-keyword=polyethylene kn-keyword=polyethylene en-keyword=polyvinyl alcohol kn-keyword=polyvinyl alcohol END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue= article-no= start-page=17 end-page=22 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=200411 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of biodegradability for polyethylene glycol via numerical simulation kn-title=数値シミュレーションによるポリエチレングリコール生分解性解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We examined the biodegradability of polyethylene glycol by analyzing gel permeation chromatography patterns, which were obtained before and after cultivation of a microbial consortium E-1 in culture media containing polyethylene glycol as its sole carbon source. We solved an inverse problem of the initial value problem, which consists of an exogenous depolymerization model and the initial weight distribution, in order to determine an oxidation rate, for which the solution of the initial value problem also satisfies the final condition. Given the oxidation rate, we simulated the transition of the weight distribution solving the initial value problem. We interpret the result that reflects a physical significance of the molecular weight on the oxidation rate, and reach a conclusion concerning the role of the membrane transport in exogenous depolymerization processes. en-copyright= kn-copyright= en-aut-name=WatanabeMasaji en-aut-sei=Watanabe en-aut-mei=Masaji kn-aut-name=渡辺雅二 kn-aut-sei=渡辺 kn-aut-mei=雅二 aut-affil-num=1 ORCID= en-aut-name=KawaiFusako en-aut-sei=Kawai en-aut-mei=Fusako kn-aut-name=河合富佐子 kn-aut-sei=河合 kn-aut-mei=富佐子 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学環境理工学部 affil-num=2 en-affil= kn-affil=岡山大学資源生物科学研究所 en-keyword=biodegradation kn-keyword=biodegradation en-keyword=polyethylene glycol kn-keyword=polyethylene glycol en-keyword=exogenous depolymerization kn-keyword=exogenous depolymerization en-keyword=mathematical model kn-keyword=mathematical model en-keyword=numerical simulation kn-keyword=numerical simulation END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=1 article-no= start-page=17 end-page=25 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Dual tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-I receptor exhibits an anticancer effect in esophageal adenocarcinoma in vitro and in vivo kn-title=Focal adhesion kinase (FAK) と Insulin-like growth factor-I receptor (IGF-IR) に対するデュアルチロシンキナーゼ阻害剤の食道腺癌における抗腫瘍効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeNobuyuki en-aut-sei=Watanabe en-aut-mei=Nobuyuki kn-aut-name=渡辺信之 kn-aut-sei=渡辺 kn-aut-mei=信之 aut-affil-num=1 ORCID= en-aut-name=TakaokaMunenori en-aut-sei=Takaoka en-aut-mei=Munenori kn-aut-name=髙岡宗徳 kn-aut-sei=髙岡 kn-aut-mei=宗徳 aut-affil-num=2 ORCID= en-aut-name=SakuramaKazufumi en-aut-sei=Sakurama en-aut-mei=Kazufumi kn-aut-name=櫻間一史 kn-aut-sei=櫻間 kn-aut-mei=一史 aut-affil-num=3 ORCID= en-aut-name=TomonoYasuko en-aut-sei=Tomono en-aut-mei=Yasuko kn-aut-name=友野靖子 kn-aut-sei=友野 kn-aut-mei=靖子 aut-affil-num=4 ORCID= en-aut-name=HatakeyamaShinji en-aut-sei=Hatakeyama en-aut-mei=Shinji kn-aut-name=畠山慎二 kn-aut-sei=畠山 kn-aut-mei=慎二 aut-affil-num=5 ORCID= en-aut-name=OhmoriOsamu en-aut-sei=Ohmori en-aut-mei=Osamu kn-aut-name=大森修 kn-aut-sei=大森 kn-aut-mei=修 aut-affil-num=6 ORCID= en-aut-name=MotokiTakayuki en-aut-sei=Motoki en-aut-mei=Takayuki kn-aut-name=元木崇之 kn-aut-sei=元木 kn-aut-mei=崇之 aut-affil-num=7 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name=白川靖博 kn-aut-sei=白川 kn-aut-mei=靖博 aut-affil-num=8 ORCID= en-aut-name=YamatsujiTomoki en-aut-sei=Yamatsuji en-aut-mei=Tomoki kn-aut-name=山辻知樹 kn-aut-sei=山辻 kn-aut-mei=知樹 aut-affil-num=9 ORCID= en-aut-name=HaisaMinoru en-aut-sei=Haisa en-aut-mei=Minoru kn-aut-name=羽井佐実 kn-aut-sei=羽井佐 kn-aut-mei=実 aut-affil-num=10 ORCID= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=11 ORCID= en-aut-name=BeerDavid G. en-aut-sei=Beer en-aut-mei=David G. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=NagatsukaHitoshi en-aut-sei=Nagatsuka en-aut-mei=Hitoshi kn-aut-name=長塚仁 kn-aut-sei=長塚 kn-aut-mei=仁 aut-affil-num=13 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=14 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=4 en-affil= kn-affil=重井医学研究所 affil-num=5 en-affil= kn-affil=ノバルティスファーマ　筑波研究所 affil-num=6 en-affil= kn-affil=ノバルティスファーマ　筑波研究所 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=10 en-affil= kn-affil=岡山市立市民病院　外科 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=12 en-affil= kn-affil=ミシガン大学　胸部外科 affil-num=13 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　口腔病理学 affil-num=14 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=15 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 en-keyword=focal adhesion kinase (FAK) kn-keyword=focal adhesion kinase (FAK) en-keyword=バレット食道癌 kn-keyword=バレット食道癌 en-keyword=FAK阻害剤 kn-keyword=FAK阻害剤 END start-ver=1.4 cd-journal=joma no-vol=4 cd-vols= no-issue=1 article-no= start-page=147 end-page=158 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990226 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Photoconductive and Photovoltaic Properties in Cadmium Bismuth Aluminate Glasses en-subtitle= kn-subtitle= en-abstract= kn-abstract=Photo-induced phenomena such as photoconductive and photovoltaic effects were investigated for the glasses in CdO-Bi(2)O(3)-Al(2)O(3) system. Photoconductive effect was characterized by a slow decay of photocurrent (persitent photoconductivity). The decay rate decreased with increasing CdO content and decreasing Bi(2)O(3) content. Photovoltage was very small at room temperature but increased to an obvious value on heating. The photoconductivity and photovoltage were increased with CdO content and enhanced by heat treatment in air. The valence band spectra of X-ray photoelectron spectroscopy showed that the hybridization of Cd 4d and O 2p orbitals increases with decreasing Bi(2)O(3) content and increasing CdO content in the glasses. As the results maximum tends to flat. This type of band structure inhibits the rapid recombination of electrons and holes. The persistent photoconductivity of the glasses may be attributed to deep energy level of DX centers. Deep energy levels of the glasses are able to prevent the recombination because they have a repulsive barrier for both electron emission and capture. en-copyright= kn-copyright= en-aut-name=ChenDanping en-aut-sei=Chen en-aut-mei=Danping kn-aut-name=陳丹平 kn-aut-sei=陳 kn-aut-mei=丹平 aut-affil-num=1 ORCID= en-aut-name=WatanabeTomohiro en-aut-sei=Watanabe en-aut-mei=Tomohiro kn-aut-name=渡辺智大 kn-aut-sei=渡辺 kn-aut-mei=智大 aut-affil-num=2 ORCID= en-aut-name=MiuraYoshinari en-aut-sei=Miura en-aut-mei=Yoshinari kn-aut-name=三浦嘉也 kn-aut-sei=三浦 kn-aut-mei=嘉也 aut-affil-num=3 ORCID= en-aut-name=NanbaTokuro en-aut-sei=Nanba en-aut-mei=Tokuro kn-aut-name=難波徳郎 kn-aut-sei=難波 kn-aut-mei=徳郎 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Wuhan University of Technology affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 en-keyword=Photoconductivity kn-keyword=Photoconductivity en-keyword=Photovoltage kn-keyword=Photovoltage en-keyword=Persistent photoconductivity kn-keyword=Persistent photoconductivity en-keyword=CdO-Bi(2)O(3)-Al(2)O(3) glasses kn-keyword=CdO-Bi(2)O(3)-Al(2)O(3) glasses en-keyword=Electronic state kn-keyword=Electronic state END start-ver=1.4 cd-journal=joma no-vol=4 cd-vols= no-issue=1 article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990226 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Circadian Oscillations in Systems of Biochemical Oscillators Coupled to Stationary Systems en-subtitle= kn-subtitle= en-abstract= kn-abstract=According ot previous studies, we may expect that slow oscillations can occur in dynamics of a parameterized family of systems in which a biochemical oscillator is coupled to a stationary systems. We introduce some numerical results that confirm our expectation. The results suggest that it is possible for slow oscillations to occur in dynamics of a system in which an active oscillatory unit is coupled to a passive medium, and that it is possible for circadian oscillations to arise from fast glycolytic oscillations in such a coupled system. en-copyright= kn-copyright= en-aut-name=WatanabeMasaji en-aut-sei=Watanabe en-aut-mei=Masaji kn-aut-name=渡辺雅二 kn-aut-sei=渡辺 kn-aut-mei=雅二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=circadian rhythm kn-keyword=circadian rhythm en-keyword=glycolytic oscillation kn-keyword=glycolytic oscillation en-keyword=nonlinear oscillator kn-keyword=nonlinear oscillator END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=7 article-no= start-page=2497 end-page=2504 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental and Clinical Studies on Effects of Intraarticular Injection of Phenolcamphor Part Ⅲ. Clinical Experiences with Intraarticular Injection of Phenolcamphor kn-title=Phenolkampfer関節内注入の実験的並びに臨床的研究 第3編 Phenolkampfer関節内注入の臨床的経験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) Satisfactory results were obtained in the treatment of 22 patients of rheumatoid arthritis with intractable pain, who were not benefitted by general and local application of steroid hormone or who were not suitable for hormone therapy for side effects or associated diseases. 2) Pain on intraarticular injection of Phenolcamphor is alleviated by gradual increasing of dosage, because of its toleration. 3) Other drugs should not be injected even in which pain increases following injection of Phenolcamphor and Phenolcamphor should be injected repeatedly after evacuation of intraarticular fluid until the pain subsides. 4) Decrease of pain was marked and swelling of joint completely subsided in a chronic case with fluid accumulation in joints. There was found no relationship between severity of symptoms and of functional disturbance and effects of Phenolcamphor. 5) Effects of Phenolcamphor were persistent and neither pain, swelling and accumulation of fluid in joint recurred nor functional disturbance and adhesion developed in the case in which effects of Phenolcamphor were noted. 6) Intraarticular injection of Phenolcamphor should be attempted as a kind of local stimulant therapy in cases which hormone therapy was not effective or contraindicated and no choice of treatment was left except orthopedic method. en-copyright= kn-copyright= en-aut-name=WatanabeTakashi en-aut-sei=Watanabe en-aut-mei=Takashi kn-aut-name=渡辺高 kn-aut-sei=渡辺 kn-aut-mei=高 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=7 article-no= start-page=2487 end-page=2495 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental and Clinical Studies on Effects of Intraarticular Injection of Phenolcamphor Part Ⅱ. Experimental Studies on Skin Surface and Intraarticular Temperature in Intraarticular Injection of Phenolcamphor kn-title=Phenolkampfer関節内注入の実験的並びに臨床的研究 第2編 Phenolkampfer関節内注入時皮膚及び関節内温度についての実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Correlations between intraarticular changes and local findings and skin surface and intraarticular temperature following Phenolcamphor injection were studied to assure the possibilities of anticipating its effects and courses following Phenolcamphor injection by measurement of temperature. Phenolcamphor were injected into knee joints of three groups of normal rabbits in which 0.25 cc and 0.5 cc of Phenolcamphor, and mixed solution of 0.25 cc of Phenolcamphor and 0.25 cc of water as control were given. Temperature was measured with electric thermometer. 1) Close relationship were found between intraarticular changes and local findings, and skin surface and intraarticular temperature following intraarticular injection of Phenolcamphor. Temperature rose with increase of local inflammatory signs and falls with its regression and stabilized after two or three weeks. 2) Parallel correlation was found between skin surface and intraarticular temperature with a little high level in the latter. 3) No difference in changes of temperature was found in different amount of injected Phenolcamphor, though the Peak of temperature rise was noted slightly later in the case of a small amount of injected material than in the large amount. 4) It is of significance for observation of effects and course of Phenolcamphor injection to measure skin surface and intraarticular temperature. However, it is not feasible to measure frequently intraarticular temperature and also it is hardly acceptable to inject procaine into joint for the relief of pain in measurement of intraarticular temperature. It is not applicable to clinical use, hence measurement of skin temperature should be used as substitute for it. en-copyright= kn-copyright= en-aut-name=WatanabeTakashi en-aut-sei=Watanabe en-aut-mei=Takashi kn-aut-name=渡辺高 kn-aut-sei=渡辺 kn-aut-mei=高 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=7 article-no= start-page=2473 end-page=2486 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental and Clinical Studies on Effects of Intraarticular Injection of Phenolcamphor Part, Ⅰ. Experimental Studies on Intraarticular Injection of Phenolcamphor in Normal Rabbits kn-title=Phenolkampfer関節内注入の実験的並びに臨床的研究 第1編 正常家兎膝関節内Phenolkampfer注入実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Phenolcamphor has been used for prevention of infection and for treatment of injury and suppurative inflammation of knee joint since the World War Ⅰ. Effects of Phenolcamphor in joint, especially regarding its corrosive action, were studied. Anatomical changes developing in joint were studied macroscopically and histologically by means of Hematoxylin-Eosin and PAS stain in two groups of rabbits in which 0.25 cc and 0.5 cc of Phenolcamphor were injected into knee joint, respectively. 1) Phenolcamphor properly prepared after original method neither produces necrosis of synovial membrane and articular cartilage nor has corrosive action. 2) Phenolcamphor must be carefully injected, for arthritis deformans would be caused by technical error, and its possibility is enhanced by presence of injury of articular cartilage. 3) Effects of Phenolcamphor continues so that persistent congestion is present in synovial membrane, and dilatation of small vessels, round cell infiltration and hyperplasia of connective tissue are histologically barely noticeable. A small amonnt of serous exudate accumulates, however, neither adhesion nor functional disturbances are produced. en-copyright= kn-copyright= en-aut-name=WatanabeTakashi en-aut-sei=Watanabe en-aut-mei=Takashi kn-aut-name=渡辺高 kn-aut-sei=渡辺 kn-aut-mei=高 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=4 article-no= start-page=1191 end-page=1215 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on the Mottled Deciduous Tooth kn-title=乳歯斑状歯の研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Attention has been paid to the mottled tooth since the report of Black and McKay in 1916. Thereafter the developing mechanism of mottled teeth has been made clear to some extent by many examinations and studies, but the majority of them is that of the permanent tooth and very few works have been made on the deciduous tooth. What these few works agree in their opinions with each other is that incidence of mottled deciduous teeth is lower than that of permanent ones, but the reason for this difference is still in the stage of speculation. The results of clinical and experimental studies on the mechanism of development of mottled deciduous teeth are described in this paper. Material and Methods: The Th-Neo-Thorin Method was used for determination of fluorine. All the materials used were distilled and only the fluorine ion was isolated. 1) Numerous cases of mottled deciduous teeth were discovered when investigation of mottled teeth had been carried out in Tomita District, Tamashima City and Konko Town in Okayama Pref. in 1953. The results obtained from the studies on the relationship between their incidence and caries of deciduous teeth and on determination of the fluorine content in drinking water are as follows: a) Average number of the persons with mottled teeth was 47.84 per cent in the permanent teeth and 15.23 per cent in the deciduous teeth, in the ratio 3 to 1. And the degree of mottled teeth was M(1) in most cases and M(2) in few cases and no M(3) could be found. b) Minimal threshold of fluorine in the incidence of mottled teeth was approxiamtely 1.0 ppm. in the deciduous teeth, while 0.5 ppm. of fluorine caused mottled teeth of degree of M(1). c) Caries incidence of the deciduous teeth was as low as that of the permanent teeth; and caries incidence in case of mottled deciduous teeth was lower than that in case of permanent ones. 2) The following experiments were performed for the purpose of investigating the role the placenta played in the fluorine metabolism during pregnancy: First, the fluorine content in the placenta of pregnant women and in the drinking water taken by them selves during the pregnancy were determined both in fluorine and non-fluorine districts. Then oral examinations of the children of the mothers in the fluorine district were conducted. And the rationship of incidence of the mottled deciduous teeth to the content of fluorine in the placenta and in the drinking water was investigated and the fluorine content of the deciduous teeth was determined at the same time. The results obteined were as follows: a) When the mother took a large amount of fluoride, some of fluorine was retained in her placenta, while the rest pessed through the placenta and had an effect on the embryo. b) The higher was the content of fluorine in drinking water, the larger was the amount of fluorine retained in the placenta. c) A small amount of fluorine could be recognized in the control placenta taken from the non-fluorine district. d) Incidence of mottled deciduous teeth was dependent upon the fluorine content of drinking water. e) The larger the content of fluorine in drinking water, the more frequently seen the incidence of mottled deciduous teeth with its minimal threshold of 1.0 ppm. f) Fluorine of 334.4 ppm. on average was contained in the mottled deciduous teeth, i.e. about one third of fluorine in the mottled deciduous teeth. 3) The following animal experiments were performed in order to confirm those results mentioned above in human: Rabbits were used as experimental animals to investigate what amount of fluorine was retained in the placenta and to what extent it was transmitted to her embryo and, moreover, to determine whether there was any limit in the retention of fluorine within the placenta. a) When 0.5 mg./kg. or 1.0 mg/kg. of NaF was administered, no significant change was noticed in the fluorine content of the placenta as compared with that of the control, but maked retention of fluorine was seen, when 5.0 mg./kg. or more of NaF was given. b) When a large amount of NaF, ranging 10.0 mg./kg. to 20.0 mg./kg. was administered, fluorine passed through the placenta and was transmitted to the embryo. From the results obtained by these experiments it could be concluded that the placenta plays a definite role in fluorine metabolism during the pregnancy and its retention has an influence on the incidence of mottled deciduous teeth. en-copyright= kn-copyright= en-aut-name=WatanabeShimpei en-aut-sei=Watanabe en-aut-mei=Shimpei kn-aut-name=渡辺信平 kn-aut-sei=渡辺 kn-aut-mei=信平 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部歯科学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=11-12 article-no= start-page=2137 end-page=2144 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Case of Cushing's Syndrom kn-title=Cushing氏症候群の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The authors report a case of Cushing's syndrom with typical clinical pictures, that is, generalized adipositas, full moon face, cutaneous striae, hypertension, osteoporosis, hyperglycemia and excessive secretion of 17-ketosteroid and 17-hydrooxycorticoid. Although the patient had various clinical examination, the primary pathologic site was not found. It might be thought that the site is benign, since no general symptoms became worse during long course. en-copyright= kn-copyright= en-aut-name=WatanabeHaruo en-aut-sei=Watanabe en-aut-mei=Haruo kn-aut-name=渡辺春生 kn-aut-sei=渡辺 kn-aut-mei=春生 aut-affil-num=1 ORCID= en-aut-name=MonobeTaisei en-aut-sei=Monobe en-aut-mei=Taisei kn-aut-name=物部大成 kn-aut-sei=物部 kn-aut-mei=大成 aut-affil-num=2 ORCID= en-aut-name=NakagawaShoso en-aut-sei=Nakagawa en-aut-mei=Shoso kn-aut-name=中川昌壮 kn-aut-sei=中川 kn-aut-mei=昌壮 aut-affil-num=3 ORCID= en-aut-name=ShindoMinoru en-aut-sei=Shindo en-aut-mei=Minoru kn-aut-name=進藤稔 kn-aut-sei=進藤 kn-aut-mei=稔 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1119 end-page=1132 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Fluorescence-Microscopic Studies on Various Bone Marrow Cells by Tissue Culture Part 3. A Study on Degeneration of Leucocytes and on the Relationship between Cell Function and Fluorescence kn-title=組織培養による骨髄諸細胞の螢光顕微鏡学的研究 第3編 白血球の変性並に細胞機能と螢光との関係に関する研究 附.全編の総括 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By performing the simple method of fluorochrominized bone marrow tissue culture the author observed the degeneration picture of leucccytes, and also studied changes in fluorescence in the cells cultured under an adverse condition but added with acridine orange. The following are the results of the present experiment. 1. It has been found that the majority of commonly-known findings by supravital staining are proven to be degeneration picture of cells. 2. As for the degeneration signs, the swelling and fading of reddish orange granules can be pointed out, while in cytoplasma vacuoles either stained or unstained with acridine orange, abnormal processes, the reddening or green swelling of cytoplasma can be recognized: The nuclei have agglutinated chromatin and have become yellow, red, and swollen in green color, and in nucleoles green swelling or reddening can be observed. 3. In the degeneration picture likewise each cell type present different fluorescence. 4. When cells become shrunk, the fluorescence is red, while when cells are swollen, it is green. 5. In the cells with decreased function reddish orange granules fade quickly and their nuclei turn yellow. 6. Those cells that have lost the fluorescence of their granules, and those that have red cytoplasma and red nuclei as well as those with their nuclei green and swollen as all-dead cells. en-copyright= kn-copyright= en-aut-name=WatanabeSusumu en-aut-sei=Watanabe en-aut-mei=Susumu kn-aut-name=渡辺晋 kn-aut-sei=渡辺 kn-aut-mei=晋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1107 end-page=1117 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Flucrescence-Microscopic Studies on Various Bone Marrow Cells by Tissue Culture Part 2. Vital observations on Blood Cells of Normal Persons by Means of Fluorochrominized Bone Marrow Tissue Culture kn-title=組織培養による骨髄諸細胞の螢光顕微鏡学的研究 第2編 螢光培養法（Fluorochrominized Bone Marrow Tissue Culture）による正常人血液細胞の生態観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the present experiment the author conducted the bone marrow tissue of normal persons by the simple method of fluorochrominized bone marrow tissue culture as established in Report 1, and observed the growth zone and various bone marrow cells appearing in the zone. 1. The cells are dense in the central part of the growth zone, and the density gradually decreases towards the periphery, giving off reddish orange fluorescence diffusely with yellow and green fluorescent spots scattered in this zone. 2. Cytoplasma, is green, while mitochondria and various granules give off yellowish green or reddish orange fluorescence. However, the fluorescence of mitochondria is quite trivial, and the nuclei and nucleoles are green but nucleoles give off fluorescence earler than the nuclei. 3, In young cells green fluorescence of cytoplasma is marked, and it grows less distinct as they mature whereas reddish orange granules tend to increase along with the maturation of cells and their size is variegated. 4. In myelogenous cells reddish orange fluorescence of granules is characteristic while yellowish green fluorescence of the nuclei in lymphocytic cells. In mouocytic cells a variety of fluorescence such as green cytoplsama and reddish orange granules agglomerating around the nucleus can be recognized, and likewise fluorescence specific to each cell type can be observed in other cells. 5. The green fluorescence of cytoplasma of erythroblasts is gradually lost along with maturation, and no fluorescence can be recognized in erythrocytes, while substantia reticulofilamentosa of reticulocytes present red fluorescence. 6. When two barrier filters, GG 4 and OG 4 are used together, it is easy to differentiate cells of the erythroblast series from cells of the leucocyte series. en-copyright= kn-copyright= en-aut-name=WatanabeSusumu en-aut-sei=Watanabe en-aut-mei=Susumu kn-aut-name=渡辺晋 kn-aut-sei=渡辺 kn-aut-mei=晋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1097 end-page=1106 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Fluorescence-Microscopic Studies on Various Bone Marrow Cells by Tissue Culture Part 1. Fundamental Study on Fluorochrominized Bone Marrow Tissue Culture kn-title=組織培養による骨髄諸細胞の螢光顕微鏡学的研究 第1編 螢光培養法（Fluorochrominized Bone Marrow Tissue Culture）に関する基礎的実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Of late many investigators have come to study blood cells with fluorescence microscope, but most of these works are carried out by supravital staining method only. Therefore, the author has attempted vital observations of bone marrow cells under the fluorescence microscope by adding fluorescent dye, acridine orange, to the medium of the simple tissue culture, the method devised in our department. For this study some fundamental studies have been conducted concerning the toxicity of dye, the selection of barrier filters, the secondary fluorescence of cells, and the influence of exciting rays on the cell growth; and obtained the following results. 1. After studying the relative growth rate, the cell density index, and the wandering velocity of neutrophils it has been found that. tissue culture is possible at low concentration, under 10(-4) of the medium with acridine orange. 2. Barrier filter, OG5 , is the most suitable one for the observation of the secondary fluorescence of the cell. 3. The concentration of the acridine orange medium at which the most distinct picture of fluorescence obtainable is at 10(-4) , and the concentration at 10(-5) is the minimum at which fluorescence can be recognized. 4. The ill effect on cells due to exciting rays may be eliminated by avoiding successive exposure to the rays. 5. The author has devised a medium for the bone marrow tissue culture, consisted of a drop of serum and a drop of physiological saline solution containing 80 γ / cc vitamin B(12) and 0.2 mg / cc acridine orange, and has designated this as the simple method of fluorochrominized bone marrow tissue culture. en-copyright= kn-copyright= en-aut-name=WatanabeSusumu en-aut-sei=Watanabe en-aut-mei=Susumu kn-aut-name=渡辺晋 kn-aut-sei=渡辺 kn-aut-mei=晋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=2006 cd-vols= no-issue=1 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=奥付 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeMamoru en-aut-sei=Watanabe en-aut-mei=Mamoru kn-aut-name=渡辺護 kn-aut-sei=渡辺 kn-aut-mei=護 aut-affil-num=1 ORCID= en-aut-name=TachibanaHidenori en-aut-sei=Tachibana en-aut-mei=Hidenori kn-aut-name=橘英範 kn-aut-sei=橘 kn-aut-mei=英範 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=2006 cd-vols= no-issue=1 article-no= start-page=3 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=万葉集の秋山 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeMamoru en-aut-sei=Watanabe en-aut-mei=Mamoru kn-aut-name=渡辺護 kn-aut-sei=渡辺 kn-aut-mei=護 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=2006 cd-vols= no-issue=1 article-no= start-page=1 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=はじめに en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeMamoru en-aut-sei=Watanabe en-aut-mei=Mamoru kn-aut-name=渡辺護 kn-aut-sei=渡辺 kn-aut-mei=護 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=2006 cd-vols= no-issue=1 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeMamoru en-aut-sei=Watanabe en-aut-mei=Mamoru kn-aut-name=渡辺護 kn-aut-sei=渡辺 kn-aut-mei=護 aut-affil-num=1 ORCID= en-aut-name=TachibanaHidenori en-aut-sei=Tachibana en-aut-mei=Hidenori kn-aut-name=橘英憲 kn-aut-sei=橘 kn-aut-mei=英憲 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=11-12 article-no= start-page=503 end-page=509 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19701230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Differential Diagnosis by Scintigram of Thyroid Gland kn-title=甲状腺腫瘍のシンチグラムについて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Possiblity of differential diagnosis by means of the scintigram of thyroid gland was investigated with 15 cases with chronic inflammation, 54 with benign tumor, 22 with malignant tumor as the subjects of the study. The results are briefly summarized as follows. 1) In chronic inflammatory diseases most cases show an irregularity of the color band, and the lesion site is mostly located in the upper pole followed by the lower pole. 2) In cases of benign tumor warm nodules are decidedly predominant as compared with other diseases, and the margin is mostly either sharp or diffuse, especially sharp one in benign tumor than in malignant one. The peripheral contour is mostly concave. Enlargement of the lesion area is more often observed than in other diseases, and this tendency is especially marked in warm nodule. There can be often observed oppressive deformation. There is no difference of the color level between the right and the left sides. Lesion site does not differ from the right to the left side and it is mostly on the right exterior side and the left lower pole. 3) In malignant tumor, most cases show a large lesion. Ones with irregular margin are more numerous than in other diseases, but here it requires differentiation from inflammation. There is no swelling on the sideof lesion. The oppressive deformity is not so frequent as in benign cases. The affected side in most cases shows a lower color level as compared with healthy side. The lesion site in this case is mostly located in the upper pole. en-copyright= kn-copyright= en-aut-name=TanabeMasatada en-aut-sei=Tanabe en-aut-mei=Masatada kn-aut-name=田辺正忠 kn-aut-sei=田辺 kn-aut-mei=正忠 aut-affil-num=1 ORCID= en-aut-name=SugitaKatsuhiko en-aut-sei=Sugita en-aut-mei=Katsuhiko kn-aut-name=杉田勝彦 kn-aut-sei=杉田 kn-aut-mei=勝彦 aut-affil-num=2 ORCID= en-aut-name=MorinoYasuo en-aut-sei=Morino en-aut-mei=Yasuo kn-aut-name=森野靖雄 kn-aut-sei=森野 kn-aut-mei=靖雄 aut-affil-num=3 ORCID= en-aut-name=WatanabeSetsuo en-aut-sei=Watanabe en-aut-mei=Setsuo kn-aut-name=渡辺節生 kn-aut-sei=渡辺 kn-aut-mei=節生 aut-affil-num=4 ORCID= en-aut-name=HaisaYoshio en-aut-sei=Haisa en-aut-mei=Yoshio kn-aut-name=羽井佐芳雄 kn-aut-sei=羽井佐 kn-aut-mei=芳雄 aut-affil-num=5 ORCID= en-aut-name=KumadaYasumasa en-aut-sei=Kumada en-aut-mei=Yasumasa kn-aut-name=久万田泰昌 kn-aut-sei=久万田 kn-aut-mei=泰昌 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=79 cd-vols= no-issue=3-4 article-no= start-page=219 end-page=226 dt-received= dt-revised= dt-accepted= dt-pub-year=1967 dt-pub=19670430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Anti-tumor activity of an unsaturated fatty acid extractedfrom rabbit liver after irradiation Part. Ⅱ. Efeci on lymphatic ascites leukemia in CBA mice kn-title=X線照射後家兎肝不飽和脂肪酸の抗癌作用 第2編 CBA系マウス腫水型白血病株について附,成熟家兎末梢血液に及ぼす影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Anti-tumor activity of OX substance was studied in the lymphatic ascites leukemia in　CBA mice, induved by successive trantation of ascitescell of DBA mice. Same investigations mentioned in the previous paper were carried out and following conclusions were obtained. 1) Administration of OX substance gave arise prevention of anemia and suppression of develpment of leukemia in DBA mice with ascites leukemia. 2) OX substance gave no influence to changes of the body weiht of DBA mice with ascites leukemia 3) Life span of DBA mica was remarkably prolonged by OX substance administration. 4) OX substance inhibited the infiltration of leukemia cells in the lung, liver, speen and other organs of DBA mice. 5) OX substance schowed the strong cytotoxic effect on the ascites leukemia cells in DBA mice. 6) OX substance gave no influence to the blood picture of the normal rabbit. en-copyright= kn-copyright= en-aut-name=WatanabeTerutugu en-aut-sei=Watanabe en-aut-mei=Terutugu kn-aut-name=渡辺晃次 kn-aut-sei=渡辺 kn-aut-mei=晃次 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=79 cd-vols= no-issue=3-4 article-no= start-page=211 end-page=217 dt-received= dt-revised= dt-accepted= dt-pub-year=1967 dt-pub=19670430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Anti-tumor activity of an unsaturated fatty acid extractedfrom rabbit liver irradiation Part. I. Effect on lymphatic ascites leukemia in DBA mice kn-title=X線照射後家兎肝不飽和脂肪酸の抗癌作用 第1編 DBA系マウス腹水型白血病株について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Aanti-tumor activity of OX substance, an unsaturated fatty acid extracted from rabbit liver 24 hours after 3,000γ irradiation, was studied in lymphatic asites leukemia in methyl cholanthren induced DBA mice. OX substance was administered intravenoulsy from the tail vein of mice. Red blood cell and white blood cell count of the peripheral blood, character of ascites and morphalogical changes of ascites cells, pathalogical findings of the visceral organs, body weight and survival period of mice were observed and following results were obtained. 1) Administration of OX substance gave arise prevention of anemia and suppression of development of leukemia in DBA mice with ascites leukemia. 2) OX substance gave no influence to changes of the body weight of DBA mice with acites leukemia. 3) Life span of DBA mice was remarkably prolonged by OX substance administration. 4) OX substance inhibited the infiltration of leukemia cells in the lung, liver, spleen and other organs of DBA mice. 5) OX substznce schowed the strong cytotoxic effect on the ascites leukemia cells in DBA mice. en-copyright= kn-copyright= en-aut-name=WatanabeTerutugu en-aut-sei=Watanabe en-aut-mei=Terutugu kn-aut-name=渡辺晃次 kn-aut-sei=渡辺 kn-aut-mei=晃次 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=5-6 article-no= start-page=249 end-page=255 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Discussion on Pancreatic Calculus from Aspects of Roentgenology kn-title=膵臓結石症のレ線学的考察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The diagnosis of disseminated parapancreatic calculus is relatively easy from its specific roentgenogram, but in those cases with little roentgenographic shadow or with a solitary shadow it becomes quite difficult. Hence in the latter cases it is necessary to distinguish it from bilestone, kidney stone, peritoneal calcified lymph node, splenic venous thrombus, or duodenal diverticulosis. Therefore, for the diagnosis of the parapancreatic calculus it is important to take a single roentgenogram of the entire abdomen as well as lateral views of the abdomen, the combination of which would afford us to identify the parapancreatic calculus from the density of its shadow, its site and its size. We have recently encountered three patients with pancreatic calculus and present our observations of the cases as well as some remarks on them from the aspects of roentgenology. en-copyright= kn-copyright= en-aut-name=YamamotoMichio en-aut-sei=Yamamoto en-aut-mei=Michio kn-aut-name=山本道夫 kn-aut-sei=山本 kn-aut-mei=道夫 aut-affil-num=1 ORCID= en-aut-name=TanabeMasatada en-aut-sei=Tanabe en-aut-mei=Masatada kn-aut-name=田辺正忠 kn-aut-sei=田辺 kn-aut-mei=正忠 aut-affil-num=2 ORCID= en-aut-name=AonoKaname en-aut-sei=Aono en-aut-mei=Kaname kn-aut-name=青野要 kn-aut-sei=青野 kn-aut-mei=要 aut-affil-num=3 ORCID= en-aut-name=KumadaYasumasa en-aut-sei=Kumada en-aut-mei=Yasumasa kn-aut-name=久萬田泰昌 kn-aut-sei=久萬田 kn-aut-mei=泰昌 aut-affil-num=4 ORCID= en-aut-name=MorinoYasuo en-aut-sei=Morino en-aut-mei=Yasuo kn-aut-name=森野靖雄 kn-aut-sei=森野 kn-aut-mei=靖雄 aut-affil-num=5 ORCID= en-aut-name=WatanabeSetsuo en-aut-sei=Watanabe en-aut-mei=Setsuo kn-aut-name=渡辺節生 kn-aut-sei=渡辺 kn-aut-mei=節生 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=86 cd-vols= no-issue=3-4 article-no= start-page=133 end-page=138 dt-received= dt-revised= dt-accepted= dt-pub-year=1974 dt-pub=19740430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Case with Esophageal Leiomyoma kn-title=食道平滑筋腫の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Leiomyoma of the esophagus is a rare lesion. On this case that we reported, the right oblique chest radiogram showed the soft tissue mass in the mediastinum. The diagnosis was made by the barium swallow study. In this report, we chiefly discussed about the radiologic findings of the esophageal leiomyoma and differential diagnosis with extraesophageal tumors. en-copyright= kn-copyright= en-aut-name=MorinoYasuo en-aut-sei=Morino en-aut-mei=Yasuo kn-aut-name=森野靖雄 kn-aut-sei=森野 kn-aut-mei=靖雄 aut-affil-num=1 ORCID= en-aut-name=WatanabeSetsuo en-aut-sei=Watanabe en-aut-mei=Setsuo kn-aut-name=渡辺節生 kn-aut-sei=渡辺 kn-aut-mei=節生 aut-affil-num=2 ORCID= en-aut-name=TakagiHisao en-aut-sei=Takagi en-aut-mei=Hisao kn-aut-name=高木寿生 kn-aut-sei=高木 kn-aut-mei=寿生 aut-affil-num=3 ORCID= en-aut-name=EbaraKazuhiko en-aut-sei=Ebara en-aut-mei=Kazuhiko kn-aut-name=江原一彦 kn-aut-sei=江原 kn-aut-mei=一彦 aut-affil-num=4 ORCID= en-aut-name=TamaiToyosato en-aut-sei=Tamai en-aut-mei=Toyosato kn-aut-name=玉井豊理 kn-aut-sei=玉井 kn-aut-mei=豊理 aut-affil-num=5 ORCID= en-aut-name=TanabeMasatada en-aut-sei=Tanabe en-aut-mei=Masatada kn-aut-name=田辺正忠 kn-aut-sei=田辺 kn-aut-mei=正忠 aut-affil-num=6 ORCID= en-aut-name=IidaSosuke en-aut-sei=Iida en-aut-mei=Sosuke kn-aut-name=飯田荘介 kn-aut-sei=飯田 kn-aut-mei=荘介 aut-affil-num=7 ORCID= en-aut-name=FujiwaraKanzi en-aut-sei=Fujiwara en-aut-mei=Kanzi kn-aut-name=藤原幹治 kn-aut-sei=藤原 kn-aut-mei=幹治 aut-affil-num=8 ORCID= en-aut-name=HaisaYoshio en-aut-sei=Haisa en-aut-mei=Yoshio kn-aut-name=羽井佐芳雄 kn-aut-sei=羽井佐 kn-aut-mei=芳雄 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=83 cd-vols= no-issue=11-12 article-no= start-page=531 end-page=536 dt-received= dt-revised= dt-accepted= dt-pub-year=1971 dt-pub=19711230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Case with Myxoma Accompanying pericardial Cyst kn-title=心膜憩室に合併せる粘液腫の一症例について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Disease exhibiting an abnormal tumorous shadow on the pericardium in x-ray picture is rare, and that with pericardial cyst is still more scarce. Having encountered a case, suspected of pericardial cyst, which on surgical operation proved to be of pericardial diveaticle accompanied by myxoma, we presented details of our findings on this very rare case. en-copyright= kn-copyright= en-aut-name=YamamotoMichio en-aut-sei=Yamamoto en-aut-mei=Michio kn-aut-name=山本道夫 kn-aut-sei=山本 kn-aut-mei=道夫 aut-affil-num=1 ORCID= en-aut-name=AonoKaname en-aut-sei=Aono en-aut-mei=Kaname kn-aut-name=青野要 kn-aut-sei=青野 kn-aut-mei=要 aut-affil-num=2 ORCID= en-aut-name=TanabeMasatada en-aut-sei=Tanabe en-aut-mei=Masatada kn-aut-name=田辺正忠 kn-aut-sei=田辺 kn-aut-mei=正忠 aut-affil-num=3 ORCID= en-aut-name=MorinoYasuo en-aut-sei=Morino en-aut-mei=Yasuo kn-aut-name=森野靖雄 kn-aut-sei=森野 kn-aut-mei=靖雄 aut-affil-num=4 ORCID= en-aut-name=WatanabeSetsuo en-aut-sei=Watanabe en-aut-mei=Setsuo kn-aut-name=渡辺節生 kn-aut-sei=渡辺 kn-aut-mei=節生 aut-affil-num=5 ORCID= en-aut-name=EbaraKazuhiko en-aut-sei=Ebara en-aut-mei=Kazuhiko kn-aut-name=江原一彦 kn-aut-sei=江原 kn-aut-mei=一彦 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学敎室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学敎室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学敎室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学敎室 affil-num=5 en-affil= kn-affil=岡山大学医学部放射線医学敎室 affil-num=6 en-affil= kn-affil=岡山大学医学部放射線医学敎室 END start-ver=1.4 cd-journal=joma no-vol=83 cd-vols= no-issue=11-12 article-no= start-page=523 end-page=529 dt-received= dt-revised= dt-accepted= dt-pub-year=1971 dt-pub=19711230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Some Consideration on Contracture of the Pyloric Antrum kn-title=胃前庭部攣縮に対する考察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In our routine X-ray examinations of the stomach we do no longer encounter much difficulty in the diagnosis of the case. By virtue of a marked improvement of the X-ray instruments as well as by a great advance in techniques of the diagnosis we now can use endoscope, fibrinoscope, cytological examinations among others that our diagnosis is betting more and more accurate, as revealed by many reports. Nonetheless, the difficulty we encounter in our X-ray diagnosis is in those cases with contracture or deformation in the pyloric antrum. Of course, in the cases with malignant pathological changes or ulcers, we face relatively less problems, but in those cases with various pathological changes on the mucous coat such as an irregular relief, a partial hypertropy or lacking in any definite finding, we find it difficult to decide whether such changes have been elicited by gastritis or other causes. We discussed about how we might handle when we meet such cases with contracture of the pyloric antrum. en-copyright= kn-copyright= en-aut-name=YamamotoMichio en-aut-sei=Yamamoto en-aut-mei=Michio kn-aut-name=山本道夫 kn-aut-sei=山本 kn-aut-mei=道夫 aut-affil-num=1 ORCID= en-aut-name=AonoKaname en-aut-sei=Aono en-aut-mei=Kaname kn-aut-name=青野要 kn-aut-sei=青野 kn-aut-mei=要 aut-affil-num=2 ORCID= en-aut-name=MorinoYasuo en-aut-sei=Morino en-aut-mei=Yasuo kn-aut-name=森野靖雄 kn-aut-sei=森野 kn-aut-mei=靖雄 aut-affil-num=3 ORCID= en-aut-name=WatanabeSetsuo en-aut-sei=Watanabe en-aut-mei=Setsuo kn-aut-name=渡辺節生 kn-aut-sei=渡辺 kn-aut-mei=節生 aut-affil-num=4 ORCID= en-aut-name=IidaSosuke en-aut-sei=Iida en-aut-mei=Sosuke kn-aut-name=飯田荘介 kn-aut-sei=飯田 kn-aut-mei=荘介 aut-affil-num=5 ORCID= en-aut-name=FujiwaraKanji en-aut-sei=Fujiwara en-aut-mei=Kanji kn-aut-name=藤原幹治 kn-aut-sei=藤原 kn-aut-mei=幹治 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=85 cd-vols= no-issue=3-4 article-no= start-page=145 end-page=150 dt-received= dt-revised= dt-accepted= dt-pub-year=1973 dt-pub=19730430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Irradiation On Lipid Peroxidation in Rat Organs.Part Ⅲ. Effects of irradiation on lipid peroxide formation and administration of radiation-protective agents (in vivo) in rat organs kn-title=ラット臓器の脂質過酸化反応におよぼす放射線照射の影響 第3編 放射線照射ラツト各臓器の脂質過酸化物形成能に及ぼす放射線防護物質投与(in vivo)の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Effects of tathione and cepharanthin, the radiation-protective agents, on the lipid peroxidation in rat organs were studied, and obtained the results as follows. (1) The acceleration of lipid peroxide formation induced by X-irradiation can be inhibited by the administration of tathione prior to the irradiation and by the dose administered. Such an inhibitory effect is especially marked in the liver, and as reported in Part Ⅰ and Part Ⅱ, in view of correlations among X-irradiation effect, lipid peroxidation and fatty acid composition in the liver, it seems that glutathione in vivo is somehow involved in the acceleration of lipid peroxidation. (2) The increase of lipid content observable in the liver of X-irradiated animal could not be observed in the animals administered with tathione. (3) Cepharanthin showed not any relation to the lipid peroxidation. en-copyright= kn-copyright= en-aut-name=WatanabeSetsuo en-aut-sei=Watanabe en-aut-mei=Setsuo kn-aut-name=渡辺節生 kn-aut-sei=渡辺 kn-aut-mei=節生 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=85 cd-vols= no-issue=3-4 article-no= start-page=137 end-page=143 dt-received= dt-revised= dt-accepted= dt-pub-year=1973 dt-pub=19730430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Irradiation on Lipid Peroxidation In Rat Organs. Part Ⅱ. Changes in lipid peroxidation and ratio of fatty acid composition in rat organs after irradiation kn-title=ラット臓器の脂質過酸化反応におよぼす放射線照射の影響 第2編 放射線照射ラット臓器における脂質過酸化反応と脂肪酸構成比の変動について en-subtitle= kn-subtitle= en-abstract= kn-abstract=With four groups of rats, normal, irradiated, fasting, and irradiated-then-fasting rats (dose of X-ray, 650R), 48 hours afterwards, liver, heart, spleen and kidney were examined separately as to changes in the acceleration of lipid peroxidation and fatty acids due to irradiation were examined and obtained the results as follows. (1) The lipid peroxidation in each organ was accelerated after irradiation when compared to that in the organs of normal group. In the fasting group the acceleration of lipid peroxidation was observed, but the acceleration in the irradiated group was far more marked, indicating clearly the effect of irradiation. (2) As to changes in the ratio of fatty acid composition in every organ of the irradiated group there were observed an increase in the ratio of high unsaturated fatty acids and a decrease in the ratio of saturated fatty acids as compared with the respective values in normal group. Among organs there could be recognized no uniform change in the fasting group and the irradiated-then-fasting group. These results indicate that the fasting affects the ratio of fatty acid composition, especially marked was change in triglyceride fraction. (3) The lipid content in the liver tends to increase after irradiation, and there is also observed an incrase in the ratio of lipids to phospholipids. (4) The arachidonic acid of phospholipid what is considered to be substrate of lipid peroxidation is increased in the irradiated group, suggesting its relation to the acceleration of lipid peroxidation accompanying irradiation, and actually, the arachidonic acid ratio of phospholipid is markedly decreased after the incubation of lipid peroxidation reaction in the presence of Fe(++), indicating that this substance can play the role of substrate. en-copyright= kn-copyright= en-aut-name=WatanabeSetsuo en-aut-sei=Watanabe en-aut-mei=Setsuo kn-aut-name=渡辺節生 kn-aut-sei=渡辺 kn-aut-mei=節生 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=85 cd-vols= no-issue=3-4 article-no= start-page=129 end-page=136 dt-received= dt-revised= dt-accepted= dt-pub-year=1973 dt-pub=19730430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Irradiation on Lipid Peroxidation in Rat Organs.Part Ⅰ. Effects of whole body irradiation on lipid peroxide formation in rat organs. kn-title=ラット臓器の脂質過酸化反応におよぼす放射線照射の影響 第1編 放射線全身照射ラット臓器の脂質過酸化物形成能について en-subtitle= kn-subtitle= en-abstract= kn-abstract=After the whole body X-irradiation (650R) of rats, the lipid peroxide formation of various organs were estimated by the TBA reaction, and the results are presented as follows: (1) In TBA reaction tests on the lipid peroxidation in the liver, heart, spleen and kidney with homogenates being incubated, the TBA value were slightly high with endogenous homogenates, but on the addition of Fe(++) the reaction was further accelerated markedly. With liver and kidney that showed a high reaction on addition of Fe(++), the reaction was similarly accelerated on addition of ascorbic acid, but with heart and spleen the reaction at initial stage did not show any significant difference from that of the group without any addition. (2) In every organ from the irradiated animal the activity of lipid peroxide formation was greater than that in organs from non-irradiated control animals. (3) TBA value in the group added with Fe(++) were higher than those in the group without any addition, suggesting that X-irradiation greatly the lipid peroxidation in organs. (4) Change in the acceleration of lipid peroxidation accompanying the irradiation appears as a shortening of reaction-induction time. (5) Radioactivity-dose dependent change can be observed only in the liver, and the time-lapse change after irradiation can also observed only in the liver. (6) These results suggest that the lipid peroxidation following the whole body X-irradiation shows a significant change primarily in the liver. en-copyright= kn-copyright= en-aut-name=WatanabeSetsuo en-aut-sei=Watanabe en-aut-mei=Setsuo kn-aut-name=渡辺節生 kn-aut-sei=渡辺 kn-aut-mei=節生 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=92 cd-vols= no-issue=3-4 article-no= start-page=455 end-page=461 dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=19800430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An autopsy case of liver cirrhosis with hepatic encephalopathy and intracranial bleeding kn-title=肝性脳症慢性型を呈する肝硬変症にみられた頭蓋内出血の1剖検例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bloody cerebrospinal fluid indicated that the neuropsychiatric abnormalities observed in a cirrhotic patient with a chronic type of hepatic encephalopathy were due to intracranial vascular lesions. Autopsy findings revealed hemorrhagic infarction at the left frontal pole and subarachinoideal bleeding at the occipital lobe. It is particularly important to realize that abnormal mental states occurring in patients with cirrhosis of the liver may be due to many other conditions leading to coma. en-copyright= kn-copyright= en-aut-name=WatanabeAkiharu en-aut-sei=Watanabe en-aut-mei=Akiharu kn-aut-name=渡辺明治 kn-aut-sei=渡辺 kn-aut-mei=明治 aut-affil-num=1 ORCID= en-aut-name=IzumiMasaki en-aut-sei=Izumi en-aut-mei=Masaki kn-aut-name=泉正樹 kn-aut-sei=泉 kn-aut-mei=正樹 aut-affil-num=2 ORCID= en-aut-name=MizutaniShigeki en-aut-sei=Mizutani en-aut-mei=Shigeki kn-aut-name=水谷繁樹 kn-aut-sei=水谷 kn-aut-mei=繁樹 aut-affil-num=3 ORCID= en-aut-name=FujiiToshitake en-aut-sei=Fujii en-aut-mei=Toshitake kn-aut-name=藤井利武 kn-aut-sei=藤井 kn-aut-mei=利武 aut-affil-num=4 ORCID= en-aut-name=WatanabeMasahiro en-aut-sei=Watanabe en-aut-mei=Masahiro kn-aut-name=渡辺正博 kn-aut-sei=渡辺 kn-aut-mei=正博 aut-affil-num=5 ORCID= en-aut-name=HigashiToshihiro en-aut-sei=Higashi en-aut-mei=Toshihiro kn-aut-name=東俊宏 kn-aut-sei=東 kn-aut-mei=俊宏 aut-affil-num=6 ORCID= en-aut-name=YoshidaHideki en-aut-sei=Yoshida en-aut-mei=Hideki kn-aut-name=吉田英紀 kn-aut-sei=吉田 kn-aut-mei=英紀 aut-affil-num=7 ORCID= en-aut-name=EndoHiroshi en-aut-sei=Endo en-aut-mei=Hiroshi kn-aut-name=遠藤浩 kn-aut-sei=遠藤 kn-aut-mei=浩 aut-affil-num=8 ORCID= en-aut-name=NagashimaHideo en-aut-sei=Nagashima en-aut-mei=Hideo kn-aut-name=長島秀夫 kn-aut-sei=長島 kn-aut-mei=秀夫 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一内科学教室 en-keyword=肝性脳症慢性型 kn-keyword=肝性脳症慢性型 en-keyword=肝硬変 kn-keyword=肝硬変 en-keyword=頭蓋内出血 kn-keyword=頭蓋内出血 END start-ver=1.4 cd-journal=joma no-vol=92 cd-vols= no-issue=1-2 article-no= start-page=267 end-page=271 dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=19800228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Increased disappearance rate of 1-(2-tetrahydrofuryl)-5-fluorouracil in reduced glutathione- or vitamin E-treated rats and its unresponsiveness to these drugs in carbon tetrachloride-injured rats kn-title=四塩化炭素肝障害ラットにおける1-(2-Tetrahydrofuryl)-5-fluorouracilの血中消失速度定数に及ぼす還元型グルタチオンとビタミンEの影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The pharmacokinetics of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) were analysed by measuring its disappearance rate (K) from the circulating blood using a high-pressure liquid chromatographic technique. An increase in the disappearance rate of FT was observed by treatment with reduced glutathione (GSH)- or tocopheryl nicotinate-treated rats. The clearance rates of FT from the circulating blood in carbon tetrachloride (CCl(4))-injured rats were much smaller than those in untreated rats. The unresponsiveness of K values to treatment with GSH or tocopheryl nicotinate was seen in liver-injured rats. en-copyright= kn-copyright= en-aut-name=HobaraNorio en-aut-sei=Hobara en-aut-mei=Norio kn-aut-name=芳原準男 kn-aut-sei=芳原 kn-aut-mei=準男 aut-affil-num=1 ORCID= en-aut-name=WatanabeAkiharu en-aut-sei=Watanabe en-aut-mei=Akiharu kn-aut-name=渡辺明治 kn-aut-sei=渡辺 kn-aut-mei=明治 aut-affil-num=2 ORCID= en-aut-name=NagashimaHideo en-aut-sei=Nagashima en-aut-mei=Hideo kn-aut-name=長島秀夫 kn-aut-sei=長島 kn-aut-mei=秀夫 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 en-keyword=四塩化炭素肝障害 kn-keyword=四塩化炭素肝障害 en-keyword=FT kn-keyword=FT en-keyword=ビタミンE kn-keyword=ビタミンE en-keyword=還元型グルタチオン kn-keyword=還元型グルタチオン en-keyword=血中消失速度定数 kn-keyword=血中消失速度定数 END start-ver=1.4 cd-journal=joma no-vol=92 cd-vols= no-issue=1-2 article-no= start-page=195 end-page=204 dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=19800228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Case report of familial juvenile polyposis of the stomach -Supplementary data kn-title=若年性胃ポリポーシスの1家系―知見補遺 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Innumerable juvenile polyps were recognised in the stomach of an 18-year-old girl. The clinical and pathological observations of the propositus have been already reported (in "Japanese Journal of Gastroenterology" and "Gastroenterology"). Her elder brother underwent a subtotal gastrectomy because of gastric polyposis at 14 years of age. Supplementary data of their clinical findings are given. They had no extragastric polyps on roentgenographic and endoscopic studies. A classification of this hereditary syndrome as a newly designated entity, juvenile polyposis of the stomach was proposed. Both siblings are now in good health. en-copyright= kn-copyright= en-aut-name=WatanabeAkiharu en-aut-sei=Watanabe en-aut-mei=Akiharu kn-aut-name=渡辺明治 kn-aut-sei=渡辺 kn-aut-mei=明治 aut-affil-num=1 ORCID= en-aut-name=NagashimaHideo en-aut-sei=Nagashima en-aut-mei=Hideo kn-aut-name=長島秀夫 kn-aut-sei=長島 kn-aut-mei=秀夫 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科学教室 en-keyword=胃ポリポーシス kn-keyword=胃ポリポーシス en-keyword=若年性ポリポーシス kn-keyword=若年性ポリポーシス en-keyword=家族性ポリポーシス kn-keyword=家族性ポリポーシス END start-ver=1.4 cd-journal=joma no-vol=94 cd-vols= no-issue=7-8 article-no= start-page=729 end-page=734 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An analysis of nucleoproteins of replicating and nonreplicating simian virus 40 kn-title=複製型および非複製型SV40クロマチン蛋白質の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Simian virus 40 (SV40) chromatin and mature virion were extracted from formaldehyde-fixed SV40-infected CV-1 cells. Mature virion was eliminated from SV40 chromatin by sucrose density gradient centrifugation. Replicating and nonreplicating SV40 chromatin were separated on CsCl/ guanidine-HCl density gradients. Replicating SV40 chromatin was lower in density than the nonreplicating form. The analysis of chromatin proteins by polyacrylamide gel electrophoresis and silver staining revealed that replicating chromatin has less H1 histone than the nonreplicating form. en-copyright= kn-copyright= en-aut-name=IrisawaMinoru en-aut-sei=Irisawa en-aut-mei=Minoru kn-aut-name=入澤實 kn-aut-sei=入澤 kn-aut-mei=實 aut-affil-num=1 ORCID= en-aut-name=NakamuraTakashi en-aut-sei=Nakamura en-aut-mei=Takashi kn-aut-name=中村孝志 kn-aut-sei=中村 kn-aut-mei=孝志 aut-affil-num=2 ORCID= en-aut-name=WatanabeSekiko en-aut-sei=Watanabe en-aut-mei=Sekiko kn-aut-name=渡辺晰子 kn-aut-sei=渡辺 kn-aut-mei=晰子 aut-affil-num=3 ORCID= en-aut-name=OdaTakuzo en-aut-sei=Oda en-aut-mei=Takuzo kn-aut-name=小田琢三 kn-aut-sei=小田 kn-aut-mei=琢三 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部癌源研究施設生化学部 affil-num=2 en-affil= kn-affil=岡山大学医学部癌源研究施設生化学部 affil-num=3 en-affil= kn-affil=岡山大学医学部癌源研究施設生化学部 affil-num=4 en-affil= kn-affil=岡山大学医学部癌源研究施設生化学部 en-keyword=SV40 kn-keyword=SV40 en-keyword=replication kn-keyword=replication END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=流体方程式の基本解 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeTakeshi en-aut-sei=Watanabe en-aut-mei=Takeshi kn-aut-name=渡辺毅 kn-aut-sei=渡辺 kn-aut-mei=毅 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=93 cd-vols= no-issue=1-2 article-no= start-page=143 end-page=152 dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=19810228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The data processing system in the central division of surgery kn-title=中央手術部における管理情報の処理 en-subtitle= kn-subtitle= en-abstract=In order to apply computer technology to analysing information obtained from operating rooms, a special code system for processing data was established. The installation of this system should be easy for nurses and clerks to use. We decided on the codes for diseases and operations by consulting the "International Classification of Diseases" and the "Operation Name Classification of Japanese Governmental Health Insurance Fund". Using this system, we analysed 3879 cases of surgery performed at our hospital during the year 1978. This code system could be applied practically to data processing for management of the central division of surgery. Only a small number of codes covered most of the cases treated by surgical operations. kn-abstract=中央手術部における過去のデータを詳細に分析し,その結果をふまえて合理的な手術部の運営方法に改めるべきであると考えた.そこで昭和53年度の全手術患者3,879例について,手術明細表に記載されている事項をコンピュータに入力し,必要に応じて種々のデータが引き出せるようなシステムを試作した.今までこのような解析ができなかった理由は,病名および手術名があまりに多岐にわたっていてコード化することが困難であったからである.今回改訂発表されたInternational Classification of Diseasesの日本語版は,あらゆる病名を網羅していて使いやすく実用的であることが確認できた.またわが国の社会保険診療報酬規定の甲表区分番号による術名コードも,普遍性と実用性の面ですぐれていることが実証できた. en-copyright= kn-copyright= en-aut-name=ArataTakiji en-aut-sei=Arata en-aut-mei=Takiji kn-aut-name=新太喜治 kn-aut-sei=新 kn-aut-mei=太喜治 aut-affil-num=1 ORCID= en-aut-name=WatanabeYasuhiro en-aut-sei=Watanabe en-aut-mei=Yasuhiro kn-aut-name=渡辺泰宏 kn-aut-sei=渡辺 kn-aut-mei=泰宏 aut-affil-num=2 ORCID= en-aut-name=MurakamiTaiji en-aut-sei=Murakami en-aut-mei=Taiji kn-aut-name=村上泰治 kn-aut-sei=村上 kn-aut-mei=泰治 aut-affil-num=3 ORCID= en-aut-name=MaedaNaotoshi en-aut-sei=Maeda en-aut-mei=Naotoshi kn-aut-name=前田直俊 kn-aut-sei=前田 kn-aut-mei=直俊 aut-affil-num=4 ORCID= en-aut-name=IkedaYuji en-aut-sei=Ikeda en-aut-mei=Yuji kn-aut-name=池田祐治 kn-aut-sei=池田 kn-aut-mei=祐治 aut-affil-num=5 ORCID= en-aut-name=TomitaToshio en-aut-sei=Tomita en-aut-mei=Toshio kn-aut-name=冨田校郎 kn-aut-sei=冨田 kn-aut-mei=校郎 aut-affil-num=6 ORCID= en-aut-name=MitsuokaToshito en-aut-sei=Mitsuoka en-aut-mei=Toshito kn-aut-name=光岡利人 kn-aut-sei=光岡 kn-aut-mei=利人 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院中央手術部 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院中央手術部 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院中央手術部 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院中央手術部 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院中央手術部 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院中央手術部 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院中央手術部 en-keyword=手術室 kn-keyword=手術室 en-keyword=情報処理 kn-keyword=情報処理 END start-ver=1.4 cd-journal=joma no-vol=95 cd-vols= no-issue=11-12 article-no= start-page=1341 end-page=1345 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19831230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical assessment of prognosis in patients with fulminant hepatitis kn-title=劇症肝炎の予後判別の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Assessment of the prognosis of fulminant hepatitis was made from clinical findings at the time of the appearance of hepatic encephalopathy using five living and ten fatal cases of fulminant hepatitis. Those patients who died tended to be old, especially in the subacute type of fulminant hepatitis, and frequently had disseminated intravascular coagulation. Prognosis scoring by assessing clinical findings in these patients was calculated during their clinical courses. From differences in scores, the treatment performed following the occurrence of hepatic encephalopathy was judged to be effective in some of the surviving patients. Other patients died, however, because of the difficulty of sufficiently controlling complications. The prognosis scoring at the time of the appearance of encephalopathy was valid for female patients who survived. Clinical evaluation of this scoring method will be further evaluated with more cases in the future. en-copyright= kn-copyright= en-aut-name=FujiwaraMasachika en-aut-sei=Fujiwara en-aut-mei=Masachika kn-aut-name=藤原雅親 kn-aut-sei=藤原 kn-aut-mei=雅親 aut-affil-num=1 ORCID= en-aut-name=WatanabeAkiharu en-aut-sei=Watanabe en-aut-mei=Akiharu kn-aut-name=渡辺明治 kn-aut-sei=渡辺 kn-aut-mei=明治 aut-affil-num=2 ORCID= en-aut-name=NakatsukasaHarushige en-aut-sei=Nakatsukasa en-aut-mei=Harushige kn-aut-name=中務治重 kn-aut-sei=中務 kn-aut-mei=治重 aut-affil-num=3 ORCID= en-aut-name=ShiotaTetsuya en-aut-sei=Shiota en-aut-mei=Tetsuya kn-aut-name=塩田哲也 kn-aut-sei=塩田 kn-aut-mei=哲也 aut-affil-num=4 ORCID= en-aut-name=SakataTatsuro en-aut-sei=Sakata en-aut-mei=Tatsuro kn-aut-name=坂田達朗 kn-aut-sei=坂田 kn-aut-mei=達朗 aut-affil-num=5 ORCID= en-aut-name=TakeiNobuyuki en-aut-sei=Takei en-aut-mei=Nobuyuki kn-aut-name=竹井信行 kn-aut-sei=竹井 kn-aut-mei=信行 aut-affil-num=6 ORCID= en-aut-name=KobayashiMichio en-aut-sei=Kobayashi en-aut-mei=Michio kn-aut-name=小林道男 kn-aut-sei=小林 kn-aut-mei=道男 aut-affil-num=7 ORCID= en-aut-name=NagashimaHideo en-aut-sei=Nagashima en-aut-mei=Hideo kn-aut-name=長島秀夫 kn-aut-sei=長島 kn-aut-mei=秀夫 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一内科教室 en-keyword=劇症肝炎 kn-keyword=劇症肝炎 en-keyword=予後 kn-keyword=予後 en-keyword=予後判別スコア kn-keyword=予後判別スコア END start-ver=1.4 cd-journal=joma no-vol=95 cd-vols= no-issue=7-8 article-no= start-page=815 end-page=822 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19830831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=DNA replication of SV40 chromatin in isolated nuclei and effects of cytoplasmic fractions and histones on DNA synthesis kn-title=SV40感染細胞分離核におけるSV40クロマチンのDNA複製と細胞質分画及びヒストンの効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Simian virds 40 (SV40) has a relatively simple and well defined genome, and is particularly appropriate as a model for studying mammalian chromatin. A nuclear system was developed for studying in vitro replication of SV40 chromatin, and the effects of cytoplasmic fractions obtained from uninfected CV-1 cells and calf thymus histones on the DNA replication were examined. The major polymerase involved in the replicative DNA synthesis was DNA polymerase α. Product analysis of replicated DNA showed that the amounts of the replicating intermediates and the open circular form of SV40 DNA (Form II) increased by in vitro DNA synthesis conducted without the addition of cytoplasmic fractions. By the addition of cytoplasmic fractions, the twisted form of SV40 DNA (Form I) as well as its replicative form and Form II were synthesized. Replicative DNA synthesis was inhibited by the addition of histone Hl but not by the addition of core histones, when the nuclear DNA to added hiatone ratio was similar to the DNA-histone ratio in eukaryotic chromatin. en-copyright= kn-copyright= en-aut-name=MakiYoshio en-aut-sei=Maki en-aut-mei=Yoshio kn-aut-name=牧佳男 kn-aut-sei=牧 kn-aut-mei=佳男 aut-affil-num=1 ORCID= en-aut-name=IwamotoHiromichi en-aut-sei=Iwamoto en-aut-mei=Hiromichi kn-aut-name=岩本博通 kn-aut-sei=岩本 kn-aut-mei=博通 aut-affil-num=2 ORCID= en-aut-name=OmuraSachiko en-aut-sei=Omura en-aut-mei=Sachiko kn-aut-name=小村幸子 kn-aut-sei=小村 kn-aut-mei=幸子 aut-affil-num=3 ORCID= en-aut-name=WatanabeSekiko en-aut-sei=Watanabe en-aut-mei=Sekiko kn-aut-name=渡辺晰子 kn-aut-sei=渡辺 kn-aut-mei=晰子 aut-affil-num=4 ORCID= en-aut-name=OdaTakuzo en-aut-sei=Oda en-aut-mei=Takuzo kn-aut-name=小田琢三 kn-aut-sei=小田 kn-aut-mei=琢三 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部癌源研究施設生化学部門 affil-num=2 en-affil= kn-affil=岡山大学医学部癌源研究施設生化学部門 affil-num=3 en-affil= kn-affil=岡山大学医学部癌源研究施設生化学部門 affil-num=4 en-affil= kn-affil=岡山大学医学部癌源研究施設生化学部門 affil-num=5 en-affil= kn-affil=岡山大学医学部癌源研究施設生化学部門 en-keyword=SV40クロマチン kn-keyword=SV40クロマチン en-keyword=DNA複製 kn-keyword=DNA複製 en-keyword=分離核・細胞質分画 kn-keyword=分離核・細胞質分画 en-keyword=ヒストン kn-keyword=ヒストン END start-ver=1.4 cd-journal=joma no-vol=95 cd-vols= no-issue=7-8 article-no= start-page=611 end-page=621 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19830831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study of tumor specific immunity in human colon cancer. kn-title=大腸癌患者における癌特異的免疫能に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We studied the correlation of a microcytotoxicity assay (MCA) and a 3H-Uridine postlabeling lymphocytoxicity assay (TPLA). Cells of the P-4788 cell line established from the pleuritis carcinomatosa of a colon cancer patient were used as the target cells. MCA correlated well with TPLA. The cytotoxicity index in the case of P-4788 cells as the target cells was high in comparison with the cytotoxicity index when M-Hela cells, a cell line from a uterine carcinoma, were used. A mixed lymphocyte tumor reaction with allo-antigen extracted from colon cancer was done, and the stimulation index of colon cancer patients was found to be high in comparison with that of gastric cancer patients and benign disease patients. There was no significant difference between the cytotoxicity of each stage of cancer before operation. However, there were significant differences the cytotoxicity before that after operation in all stages except stage V. There was a tendency for the blocking index to increase with the advance of cancer. Serum carcinoembryonic antigen (CEA) values increased with the advance of cancer and decreased after operation in all stages. Serum CEA values correlated with the blocking index, but not with the cytotoxicity index. en-copyright= kn-copyright= en-aut-name=WatanabeTetsuo en-aut-sei=Watanabe en-aut-mei=Tetsuo kn-aut-name=渡辺哲夫 kn-aut-sei=渡辺 kn-aut-mei=哲夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=95 cd-vols= no-issue=5-6 article-no= start-page=395 end-page=403 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19830630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Reconstructive head and neck surgery kn-title=頭頸部癌の再建外科・術式及び成績 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Various surgery techniques performed on 26 advanced cancer patients using forehead, deltopectoral(D-P) and musculocutaneous(M-C) flaps were reviwed. The D-P flap presents few cosmetic problems in the head and neck region and can be used in elder patients because of little operative invasion. The M-C flap allows for reconstruction of defects in a one-stage operation which may shorten hospitalization and permit an ealier return to social life. The forehead flap is the most durable and reliable flap among them for reconstructive surgery, though it offers some cosmetic problems. In reconstruction of the esophagus after a pharyngolaryngoesophagectomy for cancer of the hypopharynx and the cervical esophagus, it seems more advantageous to use a hige flap in reconstruction than Bakamjian's original method since early detection of a local recurrence of the tumor is rendered easier with the former. There were no fatal postoperative complication, though minor necrosis, fistula, suture insufficiency and esophageal stenosis were observed, but improved with conservative treatment. Conseqently, the reliability and versatility of pedicle and muculocutaneous flaps were confirmed. As to the prognosis, the 2-year survival rate was 42.2% . The cause of death was local recurrence in 4 patients, who all died within two years, and distant metastasis in 4 patients, who all died within one year of the operation. Local recurrence and distant metastasis were also seen in 4 patients who survived. en-copyright= kn-copyright= en-aut-name=WatanabeShuichi en-aut-sei=Watanabe en-aut-mei=Shuichi kn-aut-name=渡辺周一 kn-aut-sei=渡辺 kn-aut-mei=周一 aut-affil-num=1 ORCID= en-aut-name=SaitoRhusuke en-aut-sei=Saito en-aut-mei=Rhusuke kn-aut-name=斉藤龍介 kn-aut-sei=斉藤 kn-aut-mei=龍介 aut-affil-num=2 ORCID= en-aut-name=OgawaraToshiaki en-aut-sei=Ogawara en-aut-mei=Toshiaki kn-aut-name=小河原利彰 kn-aut-sei=小河原 kn-aut-mei=利彰 aut-affil-num=3 ORCID= en-aut-name=OguraYoshio en-aut-sei=Ogura en-aut-mei=Yoshio kn-aut-name=小倉義郎 kn-aut-sei=小倉 kn-aut-mei=義郎 aut-affil-num=4 ORCID= en-aut-name=KanataniMakoto en-aut-sei=Kanatani en-aut-mei=Makoto kn-aut-name=金谷真 kn-aut-sei=金谷 kn-aut-mei=真 aut-affil-num=5 ORCID= en-aut-name=MatsubaraYuzuru en-aut-sei=Matsubara en-aut-mei=Yuzuru kn-aut-name=松原浄 kn-aut-sei=松原 kn-aut-mei=浄 aut-affil-num=6 ORCID= en-aut-name=KoikeSatoshi en-aut-sei=Koike en-aut-mei=Satoshi kn-aut-name=小池聡之 kn-aut-sei=小池 kn-aut-mei=聡之 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=2 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=3 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=4 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=5 en-affil= kn-affil=岡山済生会病院 affil-num=6 en-affil= kn-affil=国立岡山病院 affil-num=7 en-affil= kn-affil=四国がんセンター en-keyword=head and neck tumor kn-keyword=head and neck tumor en-keyword=MC flap kn-keyword=MC flap en-keyword=DP flap kn-keyword=DP flap END start-ver=1.4 cd-journal=joma no-vol=96 cd-vols= no-issue=3-4 article-no= start-page=263 end-page=270 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinicopathological Study of Squamous Cell Carcinoma of the Ear kn-title=聴器扁平上皮癌の臨床と側頭骨病理組織所見 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Seven cases of squamous cell carcinoma of the ear encountered at Okayama university hospital between 1972 and 1981 were reviewed, and a histopathological study of the temporal bone of one patient was reported. All cases were in advanced stages, T3 in five cases and T4 in two cases according to the TNM classification of ear cancer after Sakai. The external auditory canal was the primary site in five cases and the middle ear in two cases. Only two patients, whose lesions were localized in the shallow portion of the external auditory canal, had lived for a long period without any recurrence at the time of this study. In contrast, the remaining five patients whose lesions extended into the middle ear and mastoid had died of cancer. Histopathological examination of the temporal bone of one patient revealed that the tumor extended both into the internal acoustic meatus along the facial canal and to the extratemporal bone area via the eustachian tube. Additionally, in spite of extensive osteoradionecrosis over the temporal bone due to a full dose of irradiation, active tumor tissue remained in the petrous apex cells of the temporal bone.From these findings, it was assumed that carcinoma of the ear is the most difficult to treat successfully among head and neck malignancies. en-copyright= kn-copyright= en-aut-name=SaitoRyusuke en-aut-sei=Saito en-aut-mei=Ryusuke kn-aut-name=斉藤龍介 kn-aut-sei=斉藤 kn-aut-mei=龍介 aut-affil-num=1 ORCID= en-aut-name=FujimotoAkiko en-aut-sei=Fujimoto en-aut-mei=Akiko kn-aut-name=藤本明子 kn-aut-sei=藤本 kn-aut-mei=明子 aut-affil-num=2 ORCID= en-aut-name=FujitaAkira en-aut-sei=Fujita en-aut-mei=Akira kn-aut-name=藤田彰 kn-aut-sei=藤田 kn-aut-mei=彰 aut-affil-num=3 ORCID= en-aut-name=WatanabeShuichi en-aut-sei=Watanabe en-aut-mei=Shuichi kn-aut-name=渡辺周一 kn-aut-sei=渡辺 kn-aut-mei=周一 aut-affil-num=4 ORCID= en-aut-name=TomotsuTakao en-aut-sei=Tomotsu en-aut-mei=Takao kn-aut-name=鞆津尚夫 kn-aut-sei=鞆津 kn-aut-mei=尚夫 aut-affil-num=5 ORCID= en-aut-name=MisakiKeizo en-aut-sei=Misaki en-aut-mei=Keizo kn-aut-name=三崎敬三 kn-aut-sei=三崎 kn-aut-mei=敬三 aut-affil-num=6 ORCID= en-aut-name=OguraYoshio en-aut-sei=Ogura en-aut-mei=Yoshio kn-aut-name=小倉義郎 kn-aut-sei=小倉 kn-aut-mei=義郎 aut-affil-num=7 ORCID= en-aut-name=MatsubaraKiyoshi en-aut-sei=Matsubara en-aut-mei=Kiyoshi kn-aut-name=松原浄 kn-aut-sei=松原 kn-aut-mei=浄 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=8 en-affil= kn-affil=国立岡山病院耳鼻咽喉科 en-keyword=squamous cell carcinoma, kn-keyword=squamous cell carcinoma, en-keyword=external auditory canal kn-keyword=external auditory canal en-keyword=middle ear kn-keyword=middle ear en-keyword=temporal bone pathology kn-keyword=temporal bone pathology en-keyword=treatment kn-keyword=treatment END start-ver=1.4 cd-journal=joma no-vol=97 cd-vols= no-issue=7-8 article-no= start-page=761 end-page=775 dt-received= dt-revised= dt-accepted= dt-pub-year=1985 dt-pub=19850830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Identification of Lymphocyte Subsets in Lung Cancer Tissue Using Monoclonal Antibodies kn-title=モノクローナル抗体を用いた肺癌組織浸潤リンパ球の研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Subsets of the infiltrating lymphocytes in lung cancer tissues of 64 patients were identified by immunohistochemical staining (ABC method) using monoclonal antibodies (Leu 2a, Leu 3a+b, Leu 4, Leu 7 and Leu 14). T cells were predominant in lung cencer tissues, and tended to infiltrate into cancer cell nests and stoma, diffusely and focally. On the contrary, B cells in most cases were observed to infiltrate focally apart from cancer cells. There was a significant reverse correlation between the intensity of the T cell infiltration and the tumor T factors, and also between Th/i cell infiltration and the tumor T factors. Th/i cells were more prominent in lung cancer than Ts/c cells, and Ts/c cells scarcely infiltrated. NK, K cells also infiltrated scarcely and sparsely, and there was no correlation between the intensity of NK, K infiltration and the clinical condition. It was concluded that immunohistochemical examination of infiltrating lymphocyte subsets in lung cancer can reveal direct local immune responses and may be a useful method for making prognoses. en-copyright= kn-copyright= en-aut-name=WatanabeTetsuya en-aut-sei=Watanabe en-aut-mei=Tetsuya kn-aut-name=渡辺哲也 kn-aut-sei=渡辺 kn-aut-mei=哲也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科教室 en-keyword=モノクローナル抗体 kn-keyword=モノクローナル抗体 en-keyword=リンパ球サブセット kn-keyword=リンパ球サブセット en-keyword=肺癌 kn-keyword=肺癌 en-keyword=肺癌浸潤リンパ球 kn-keyword=肺癌浸潤リンパ球 en-keyword=免疫組織化学 kn-keyword=免疫組織化学 END start-ver=1.4 cd-journal=joma no-vol=97 cd-vols= no-issue=7-8 article-no= start-page=701 end-page=712 dt-received= dt-revised= dt-accepted= dt-pub-year=1985 dt-pub=19850830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental model of human lung cancer Part II. Heterotransplantation of human continuous cell lines from squamous cell carcinoma and adenocarcinoma of the lung kn-title=ヒト肺癌実験モデルの作製に関する研究　第2編　ヒト肺扁平上皮癌細胞株(EBC-1株)およびヒト肺腺癌細胞株(ABC-1株)の異種移植 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Two continuous cell lines, which were designated as EBC-1 and ABC-1, were recently established from explant cultures of human squamous cell carcinoma and adenocarcinoma of the lung in our laboratory. In the present study, for the purpose of making an animal model of human lung cancer, cells of EBC-1 and ABC-1 were transplanted into antilymphocyte serum (ALS)-treated newborn hamsters and into nude mice. The EBC-1 line was serially transplanted for 10 passages into ALS-treated newborn hamsters. When 0.75-24.0×10(5) cells were inoculated intraperitoneally or subcutaneously, 36 of 38 experimental animals developed invasive tumors 19-35 days after implantation. Metastases to the lungs were observed in 28 of 36 hamsters with tumors. The EBC-1 line was also transplantable to nude mice, but the tumor growth was very slow and serial transplantation was not successful. The ABC-1 line was transplantable to ALS-treated newborn hamsters, but propagated for only two passages. When 4.0-14.0×10(5) cells were inoculated intraperitoneally or subcutaneously, 14 of 20 experimental animals developed invasive tumors 28-33 days after implantation. The ABC-1 line was transplantable, but not serially transplantable to nude mice. In conclusion, EBC-1 when implanted into hamsters was a good model of human lung cancer. To my knowledge, this is the first report of a high frequency of lung metastases in the heterotransplantation of human lung cancer. This animal model should be useful for various studies of human lung cancer including mechanism of metastasis and chemosensitivity of anticancer agents. en-copyright= kn-copyright= en-aut-name=WatanabeYoichi en-aut-sei=Watanabe en-aut-mei=Yoichi kn-aut-name=渡辺洋一 kn-aut-sei=渡辺 kn-aut-mei=洋一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第2内科学教室 en-keyword=human lung cancer cell line kn-keyword=human lung cancer cell line en-keyword=squamous cell carcinoma kn-keyword=squamous cell carcinoma en-keyword=adenocarcinoma kn-keyword=adenocarcinoma en-keyword=heterotransplantation kn-keyword=heterotransplantation END start-ver=1.4 cd-journal=joma no-vol=97 cd-vols= no-issue=7-8 article-no= start-page=691 end-page=700 dt-received= dt-revised= dt-accepted= dt-pub-year=1985 dt-pub=19850830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental model of human lung cancer Part I. Establishment and characterization of new tissue culture cell lines from human squamous cell carcinoma and adenocarcinoma of the lung. kn-title=ヒト肺癌実験モデルの作製に関する研究　第1編　ヒト肺扁平上皮癌細胞株(EBC-1株)およびヒト肺腺癌細胞株(ABC-1株)の樹立とその性状 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Two human lung cancer cell lines designated as EBC-1 and ABC-1 were newly established for the purpose of making an in vitro experimental model of human lung cancer. The EBC-1 line was established from a metastatic skin tumor of a patient with squamous cell carcinoma of the lung. The cells grew in a monolayered sheet with a population-doubling time of 42 hr. The chromosome number showed wide variation from 35 to 102 with a modal peak at 53. The ABC-1 line was established from pleural effusion of a patient with adenocarcinoma of the lung. The cells grew mainly in a floating clump with a population-doubling time of 72 hr. Karyotypic analysis disclosed a wide variation from 25 to 57 with two modal peaks at 53 and 54. The EBC-1 and ABC-1 lines may be useful for biological, cytopharmacological and therapeutic studies of human squamous cell carcinoma and adenocarcinoma of the lung. en-copyright= kn-copyright= en-aut-name=WatanabeYoichi en-aut-sei=Watanabe en-aut-mei=Yoichi kn-aut-name=渡辺洋一 kn-aut-sei=渡辺 kn-aut-mei=洋一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第2内科学教室 en-keyword=human lung cancer cell line kn-keyword=human lung cancer cell line en-keyword=squamous cell carcinoma kn-keyword=squamous cell carcinoma en-keyword=adenocarcinoma kn-keyword=adenocarcinoma en-keyword=tissue culture kn-keyword=tissue culture END start-ver=1.4 cd-journal=joma no-vol=99 cd-vols= no-issue=9-10 article-no= start-page=1101 end-page=1116 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=19871031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Electron microscopic study of the hippocampal formation of rats after picrotoxin administration kn-title=ピクロトキシン投与後におけるラットの海馬領域の電子顕微鏡的・統計学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Changes in the granule cells of the rat dentate gyrus, hippocampal mossy fibers and moosy fiber boutons following administration of picrotoxin were examined at the ultrastructual level. In controls, many small round clear vesicles (20-40 nm in diameter) along with a small number of large dense-core vesicles (60-90 nm in diameter) filled the mossy fiber boutons. Following administration of picrotoxin, the large dense-core vesicles increased in number and accumulated on the presynaptic membrane. Some of the large dense-core vesicles appeared to be fused with the membrane and frequently exhibited omega-shaped exocytotic profiles. A greatly increased number of coated vesicles (60-90 nm in diameter) was observed on the maturing face of the Golgi fields in the cytoplasm of granule cells after injection of picrotoxin. In addition, the ends of the Golgi cisternae rods occasionally appeared to be coated, and coated large dense-core vesicles (60-80 nm in diameter) were seen in the mossy fibers. This study showed not only an increased incidence of large dense-core vesicle exocytosis during seizures, but also suggests that these vesicles are replaced in excess from the perikaryon. en-copyright= kn-copyright= en-aut-name=WatanabeHiroki en-aut-sei=Watanabe en-aut-mei=Hiroki kn-aut-name=渡辺弘樹 kn-aut-sei=渡辺 kn-aut-mei=弘樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一解剖学教室 en-keyword=picrotoxin kn-keyword=picrotoxin en-keyword=hippocampus kn-keyword=hippocampus en-keyword=coated vesicle kn-keyword=coated vesicle en-keyword=large dense-core vesicle kn-keyword=large dense-core vesicle en-keyword=electron microscopy kn-keyword=electron microscopy END start-ver=1.4 cd-journal=joma no-vol=99 cd-vols= no-issue=3-4 article-no= start-page=347 end-page=356 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=19870430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An epidemiological study of obesity and fatty liver of students in Japan kn-title=大学生の肥満と脂肪肝に関する疫学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=An epidemiological study of the relationship between obesity and fatty liver of students in Japan was performed. Measurements of subcutaneous fatty tissue (Nagamine's method) and body weight (according to the Ministry of Health and Welfare 1971-standard body weight method and 1986-standard body weight method) were used to determine obesity. The data of 6,485 18-year-old male and female students of Okayama University, obtained from records beginning 30 years ago, and the data of 1,932 students, obtained in 1986, were examined. The frequency of obesity of men increased since the nineteen-seventies (10.8% in 1986), but that of women did not change for the past 30 years. However, the frequency of emaciation of women has increased for the past 5-6 years (11.5-10.0%). Male students with negative HBs-antigen, higher GPT levels than GOT levels with one or both levels being abnormal, and high choline-esterase level (△ pH over 1.10) were suspected of having fatty liver, and many of them (85.7% by Nagamine's method, 66.7% by 1971-standard body weight method and 71.4% by 1986-method) were diagnosed as being obese. The students with fatty liver (judged by echography) had a greater frequency of obesity (86.7% by Nagamine's method, 80.0% by 1971-method and 76.7% by 1986-method) than those without fatty liver. The measurement of subcutaneous fatty tissue (Nagamine's method) was useful for screening fatty liver in students. en-copyright= kn-copyright= en-aut-name=WatanabeKunitake en-aut-sei=Watanabe en-aut-mei=Kunitake kn-aut-name=渡辺圀武 kn-aut-sei=渡辺 kn-aut-mei=圀武 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第１内科学教室 en-keyword=肥満 kn-keyword=肥満 en-keyword=脂肪肝 kn-keyword=脂肪肝 en-keyword=皮下脂肪厚 kn-keyword=皮下脂肪厚 en-keyword=肥満判定法 kn-keyword=肥満判定法 en-keyword=大学生の脂肪肝 kn-keyword=大学生の脂肪肝 END start-ver=1.4 cd-journal=joma no-vol=99 cd-vols= no-issue=3-4 article-no= start-page=239 end-page=250 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=19870430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cholelitholytic therapy for cholesterol gallstones - Dissolution efficacy and biliary bile acid composition kn-title=コレステロール胆石症に対する内科的溶解療法の検討 ―治療による胆汁中胆汁酸分画の分析も含めて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Eighty-three patients with cholesterol gallstones in a functioning gallbladder were treated with 400mg UDCA and 200mg CDCA (group A), 300mg UDCA and 300mg CDCA (group B), 200mg UDCA and 400mg CDCA (group C), 400mg CDCA alone (group D), 400mg CDCA and 240mg trihydroxy propiophenone (group E), or 600mg UDCA alone (group F). All patients were followed by cholecystography and ultrasonography. At the end of 6 months of treatment, the cumulative efficacy (complete plus partial dissolution) of all subjects were 41.0%. Twelve patients (14.5%) had complete dissolution. Group B had the highest dissolution rate (69.2%:38.5% complete and 30.7% partial dissolution), and this rate was significantly higher (p<0.01) than that of the CDCA-treated patients (group D). Diarrhea was frequently observed in patients treated with 400mg CDCA (27.8% in group D and 31.3% in group E). Combination with UDCA seemed to prevent this complication. No significant changes in the plasma lipids were observed. Changes in the bile acid composition, including lithocholic acid, did not seem to be determined solely by the doses of UDCA and CDCA. Patients whose lithogenic index dropped below 1.0 during the treatment did not always show dissolution of gallstones. Although the age of the patients, obesity and stone size did not affect the dissolution rate, the female sex and good gallbladder contractility were preferable factors for the dissolution of cholesterol gallstones. en-copyright= kn-copyright= en-aut-name=WatanabeJun-ichi en-aut-sei=Watanabe en-aut-mei=Jun-ichi kn-aut-name=渡辺淳一 kn-aut-sei=渡辺 kn-aut-mei=淳一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 en-keyword=cholelitholytic therapy kn-keyword=cholelitholytic therapy en-keyword=ursodeoxycholic acid (UDCA) kn-keyword=ursodeoxycholic acid (UDCA) en-keyword=chenodeoxycholic acid (CDCA) kn-keyword=chenodeoxycholic acid (CDCA) en-keyword=trihydroxy propiophenone kn-keyword=trihydroxy propiophenone en-keyword=lithogenic index kn-keyword=lithogenic index END start-ver=1.4 cd-journal=joma no-vol=99 cd-vols= no-issue=1-2 article-no= start-page=169 end-page=178 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=19870228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental study of the hepatic accumulation of the immune complex and its hepatocytotoxity kn-title=肝と免疫複合体：血中免疫複合体の肝への集積と肝細胞傷害性についての実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It was studied whether IgG-immune complexes were taken up by liver parenchymal cells and whether liver injury was induced by the immune complexes. When asialoorosomucoid, orosomucoid and human serum albumin immune complexes at various antigen-antibody ratios were infused into the portal vein of rats, the antibody-excess immune complexes were partly taken up by liver parenchymal cells via the asialoglycoprotein receptor. However, liver injury was not caused by the immune complexes. These observations suggest that 1) immune complexes at certain antigen-antibody ratios bind to the asialogycoprotein receptor, 2) immune complexes bound to the asialoglycoprotein receptor do not activate the complement system and 3) a transient increase in plasma immune complexes does not induce liver injury. en-copyright= kn-copyright= en-aut-name=WatanabeMasahiro en-aut-sei=Watanabe en-aut-mei=Masahiro kn-aut-name=渡辺正博 kn-aut-sei=渡辺 kn-aut-mei=正博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 en-keyword=免疫複合体 kn-keyword=免疫複合体 en-keyword=アシアロ糖蛋白質受容体 kn-keyword=アシアロ糖蛋白質受容体 en-keyword=肝障害 kn-keyword=肝障害 END start-ver=1.4 cd-journal=joma no-vol=100 cd-vols= no-issue=1-2 article-no= start-page=89 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=1988 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Tissue cathepsin B and L activities in gastric cancer with reference to pathological findings kn-title=胃癌患者における胃組織カテプシンBとL活性 ―病理学的所見との関連性― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cathepsin B and L activities in cancer tissue and non-cancerous mucosal tissue were determined with small amounts of tissue homogenate from 29 operated patients with gastric cancer. Both enzyme activities were significantly higher in cancer tissues than in noncancerous mucosal tissues. The level of cathepsin B activity was higher in specimens of poorly differentiated adenocarcinomas, deeply invaded ps (+) and extensively metastasized regional lymph nodes (n(2) or n(3)) than in specimens of tubular adenocarcinomas, invaded ps (-) and no metastasized regional lymph nodes. No significant correlation was observed between the elevated levels of cathepsin L activity in cancer tissues and any of the histological findings. These results suggest a close relationship of this enzyme to local invasion and metastasis to regional lymph nodes. en-copyright= kn-copyright= en-aut-name=WatanabeMasatomo en-aut-sei=Watanabe en-aut-mei=Masatomo kn-aut-name=渡辺正朝 kn-aut-sei=渡辺 kn-aut-mei=正朝 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1内科学教室 en-keyword=カテプシンB kn-keyword=カテプシンB en-keyword=カテプシンL kn-keyword=カテプシンL en-keyword=浸潤 kn-keyword=浸潤 en-keyword=転移 kn-keyword=転移 en-keyword=胃癌 kn-keyword=胃癌 END start-ver=1.4 cd-journal=joma no-vol=99 cd-vols= no-issue=1-2 article-no= start-page=49 end-page=56 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=19870228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Two cases of Macromolecular GOT kn-title=高分子GOT血症を呈した2症例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The first case of macromolecular GOT was reported by lida et al. in 1973, and since then only 11 cases have been reported. In the present paper, we report two cases of abnormally elevated serum GOT, which was difficult to explain by organic disorders. Using various biochemical and immunological methods, the GOT was concluded to be macromolecular GOT. Sephadex G-100 column chromatography was carried out to estimate the molecular size. After dividing the GOT into isoenzymes by Cellogel membrane electrophoresis, the GOTs were dyed using the GLDH method developed by Lippe. The immunofixation method was used to examine what kind of immunogloblin combined with GOT. Case 1 was a 69-year-old woman with angina pectoris and hypertension. Her serum GOT level was 279 IU/l. Her serum GOT was found to be combined with IgG-x. Case 2 was an 8-year-old boy who suffered from bronchial asthma. His serum GOT levels were highly elevated (192IU/L). The GOT was combined with IgG-λ. In both cases, we estimated the GOT molecular weight to be 14,0000 Daltons. en-copyright= kn-copyright= en-aut-name=MatsubaraKatashi en-aut-sei=Matsubara en-aut-mei=Katashi kn-aut-name=松原堅 kn-aut-sei=松原 kn-aut-mei=堅 aut-affil-num=1 ORCID= en-aut-name=WatanabeAkiharu en-aut-sei=Watanabe en-aut-mei=Akiharu kn-aut-name=渡辺明治 kn-aut-sei=渡辺 kn-aut-mei=明治 aut-affil-num=2 ORCID= en-aut-name=HigashiToshihiro en-aut-sei=Higashi en-aut-mei=Toshihiro kn-aut-name=東俊宏 kn-aut-sei=東 kn-aut-mei=俊宏 aut-affil-num=3 ORCID= en-aut-name=TobeKazuo en-aut-sei=Tobe en-aut-mei=Kazuo kn-aut-name=戸部和夫 kn-aut-sei=戸部 kn-aut-mei=和夫 aut-affil-num=4 ORCID= en-aut-name=NagashimaHideo en-aut-sei=Nagashima en-aut-mei=Hideo kn-aut-name=長島秀夫 kn-aut-sei=長島 kn-aut-mei=秀夫 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科学教室 en-keyword=macromolecular GOT kn-keyword=macromolecular GOT en-keyword=immunoglobulin kn-keyword=immunoglobulin en-keyword=IgG-x kn-keyword=IgG-x en-keyword=IgG-λ kn-keyword=IgG-λ END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=1 article-no= start-page=85 end-page=90 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Nursing students' images of the elderly before and after a two-week nursing practice kn-title=看護学生の老人施設実習前後の老人イメージ en-subtitle= kn-subtitle= en-abstract=This study investigated how nursing students perceived the elderly living in a nursing home for the elderly. Testing was done both before and after they experienced a two-week nursing practice at the nursing home. Three findings were obtained. (1) The students regarded the elderly not only as more humorous and vital but also less experienced, peaceful, and realistic before than after experiencing the practice. (2) Over a third of the students named humorous/not humorous as an item for which they experienced a marked change in image of the elderly. (3) The students generally regarded the elderly as being experienced, warm, bored, weak, and lonely. The findings indicate that the nursing practice provided the students with an opportunity to form better and realistic images of the elderly. kn-abstract=2週間の特別養護老人ホームの実習前及び実習後の学生の老人イメージを20項目の尺度を用いて調査した｡その結果,以下のことが明らかになった｡ 1. 実習後のイメージの平均得点は,｢ユーモアのない｣から｢ユーモアのある｣へ,｢生気のない｣から｢生気のある｣へと好ましい方向へ上昇し,一方｢経験に富む｣,｢穏やかな｣,｢現実的な｣は好ましくない方向へ変化した｡ 2. 3分の1以上の学生が実習後に特にイメージが変化した項目として｢ユーモアのない/ユーモアのある｣の項目をあげた｡ 3. 老人像は全体として｢暇な｣,｢弱い｣,｢孤独な｣という否定的な老人イメージと｢経験に富む｣,｢暖かい｣という肯定的イメージで捉えられており,このイメージは実習前後で共通していた｡実習前後では全体として老人像に大きな変化はなかったものの,実習によって,より活動的な老人イメージを抱き,より現実的に老人をとらえていることが明らかになり,A園での老人看護学実習は教育上意義のある実習であると評価した｡ en-copyright= kn-copyright= en-aut-name=WatanabeKumi en-aut-sei=Watanabe en-aut-mei=Kumi kn-aut-name=渡辺久美 kn-aut-sei=渡辺 kn-aut-mei=久美 aut-affil-num=1 ORCID= en-aut-name=KondoMasuko en-aut-sei=Kondo en-aut-mei=Masuko kn-aut-name=近藤益子 kn-aut-sei=近藤 kn-aut-mei=益子 aut-affil-num=2 ORCID= en-aut-name=OhtaNiwa en-aut-sei=Ohta en-aut-mei=Niwa kn-aut-name=太田にわ kn-aut-sei=太田 kn-aut-mei=にわ aut-affil-num=3 ORCID= en-aut-name=IkedaToshiko en-aut-sei=Ikeda en-aut-mei=Toshiko kn-aut-name=池田敏子 kn-aut-sei=池田 kn-aut-mei=敏子 aut-affil-num=4 ORCID= en-aut-name=MaedaMakiko en-aut-sei=Maeda en-aut-mei=Makiko kn-aut-name=前田真紀子 kn-aut-sei=前田 kn-aut-mei=真紀子 aut-affil-num=5 ORCID= en-aut-name=OhtaTakeo en-aut-sei=Ohta en-aut-mei=Takeo kn-aut-name=太田武夫 kn-aut-sei=太田 kn-aut-mei=武夫 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=4 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=5 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=6 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 en-keyword=老人 (elderly) kn-keyword=老人 (elderly) en-keyword=イメージ (images) kn-keyword=イメージ (images) en-keyword=看護学生 (nursing students) kn-keyword=看護学生 (nursing students) en-keyword=看護実習 (nursing practice) kn-keyword=看護実習 (nursing practice) en-keyword=看護教育 (nursing education) kn-keyword=看護教育 (nursing education) END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=1 article-no= start-page=33 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The relation of Ikigai (the meaning of one's life) to one's behavioral pattern and belief, researched through the elderly persons at their discharge from hospital kn-title=老人の退院時における生きがいと生活行動および生活信条との関連 en-subtitle= kn-subtitle= en-abstract=There have been few researches about Ikigai of the elderly at the time of leaving the hospital and about the ways of their home nursing care. The purpose of this study is to clarify the relation of Ikigai to one's behavioral pattern and belief. In three national university hospitals and a general hospital in Chugoku region and Shikoku region, ninety-two patients above the age of 70, ready to discharge, were interviewed and given a questionnaire. The questions were about their body condition, behavioral pattern, and belief, and their Ikigai. More than eighty percent of them seem to lead a life worth living at the time of leaving the hospital. The behavioral pattern scores on the "working as a volunteer" and "growing plants" are on a high level of Ikigai. The belief scores on the "enjoy every day" is also on a high level of Ikigai. In this paper the result of this interview is reported and a better nursing care for them is discussed. kn-abstract=退院を控えた老人が,どの程度生きがいを持って退院していくのか,老人自身のどのような生き方が生きがいに影響しているのかについて知るため,それまでの健康状態や,生活信条,生活行動について,退院許可の出た70歳以上の患者92名を対象として,独自の調査用紙に基づき面接調査を行った｡生きが いとこれまでの健康度,生活信条,生活行動の関連性を,分散分析及びt検定により解析した｡生きがいの平均得点が高かった生活行動は｢ボランティア｣で,続いて｢植物｣であった。生きがいの平均得点が高かった生活信条は｢その日を楽しく生きる｣と回答した人が,回答しなかった人との間に有意差があり,老人の退院時の生きがいの得点が高い傾向を示すことが明らかとなった｡ en-copyright= kn-copyright= en-aut-name=WatanabeKumi en-aut-sei=Watanabe en-aut-mei=Kumi kn-aut-name=渡辺久美 kn-aut-sei=渡辺 kn-aut-mei=久美 aut-affil-num=1 ORCID= en-aut-name=NakanishiYoshiko en-aut-sei=Nakanishi en-aut-mei=Yoshiko kn-aut-name=中西代志子 kn-aut-sei=中西 kn-aut-mei=代志子 aut-affil-num=2 ORCID= en-aut-name=IkedaToshiko en-aut-sei=Ikeda en-aut-mei=Toshiko kn-aut-name=池田敏子 kn-aut-sei=池田 kn-aut-mei=敏子 aut-affil-num=3 ORCID= en-aut-name=TakataSetuko en-aut-sei=Takata en-aut-mei=Setuko kn-aut-name=高田節子 kn-aut-sei=高田 kn-aut-mei=節子 aut-affil-num=4 ORCID= en-aut-name=KondoMasuko en-aut-sei=Kondo en-aut-mei=Masuko kn-aut-name=近藤益子 kn-aut-sei=近藤 kn-aut-mei=益子 aut-affil-num=5 ORCID= en-aut-name=OhtaNiwa en-aut-sei=Ohta en-aut-mei=Niwa kn-aut-name=太田にわ kn-aut-sei=太田 kn-aut-mei=にわ aut-affil-num=6 ORCID= en-aut-name=InoshitaHikari en-aut-sei=Inoshita en-aut-mei=Hikari kn-aut-name=猪下光 kn-aut-sei=猪下 kn-aut-mei=光 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=4 en-affil= kn-affil=広島県立保健福祉短期大学 affil-num=5 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=6 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=7 en-affil= kn-affil=香川医科大学医学部看護学科 en-keyword=老人 (the elderly) kn-keyword=老人 (the elderly) en-keyword=生きがい (Ikigai) kn-keyword=生きがい (Ikigai) en-keyword=生活信条 (belief) kn-keyword=生活信条 (belief) en-keyword=生活行動 (behavioral pattern) kn-keyword=生活行動 (behavioral pattern) END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=1 article-no= start-page=1 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of six cases of renal transplant recipients havingcomplaints about transplanted kidney and medical care. kn-title=移植された腎臓と医療に不満を抱く腎移植者6事例の分析 en-subtitle= kn-subtitle= en-abstract=The purpose of our nursing study is to know how we can improve QOL (Quality of Life) of renal transplant recipients. Our study uses nursing intervention. Now we examine effective nursing intervention necessary for improving this QOL. The result of this study comes from analyzing the cases of six renal transplant recipients. They had some complaints about their transplanted kidney and medical care. Depending on this analytical result, we examined renal transplant nursing. As a result, the following five items became clear concerning the complaints of these six recipients. Those were, (1) physical state, (2) ability to achieve their responsibility and social support, (3) self-realization and their view of life, (4) work and their economic independence, (5) relation to their family. These six recipients' physical states were in bad condition and had complaints about their health. All of the living donor kidney transplant recipients had complaints about the role in their family and their social role to others. Male transplant recipients were not satisfied with the social support. These analytical results are important for our nursing to improve QOL of renal transplant recipients. kn-abstract=これまで､腎移植者のQOLの向上をめざした系統的アプローチを看護援助モデルを基に検討してきた｡そして現在､腎移植者に対する効果的かつ具体的な看護介入について検討を進めている｡本研究では､移植された腎臓と受けている医療に不満を抱く腎移植者6名の事例分析を基に､腎移植者への看護的関わりを検討した｡その結果､この6名の移植者が抱く不満は､身体状態､責任を果す能力と周囲のサポート､自己実現と人生観､仕事と経済的自立､家族との関係の5つのカテゴリーに分類された｡そして､6名に共通する不満は､身体状態の問題に起因した健康に対してであった｡また､生体腎移植者はすべて家族に対する役割や他人に対する社会的役割の達成について不満を抱いていた｡そして､男性の移植者は､周囲からのサポートに満足していなかった｡これらのことは､腎移植者のQOL向上に向けた看護介入を具体化する上で最も考慮すべき要点であることが明らかとなった｡ en-copyright= kn-copyright= en-aut-name=NakanishiYoshiko en-aut-sei=Nakanishi en-aut-mei=Yoshiko kn-aut-name=中西代志子 kn-aut-sei=中西 kn-aut-mei=代志子 aut-affil-num=1 ORCID= en-aut-name=HayashiYuko en-aut-sei=Hayashi en-aut-mei=Yuko kn-aut-name=林優子 kn-aut-sei=林 kn-aut-mei=優子 aut-affil-num=2 ORCID= en-aut-name=KanaoNaomi en-aut-sei=Kanao en-aut-mei=Naomi kn-aut-name=金尾直美 kn-aut-sei=金尾 kn-aut-mei=直美 aut-affil-num=3 ORCID= en-aut-name=WatanabeKumi en-aut-sei=Watanabe en-aut-mei=Kumi kn-aut-name=渡辺久美 kn-aut-sei=渡辺 kn-aut-mei=久美 aut-affil-num=4 ORCID= en-aut-name=HoshinaEiko en-aut-sei=Hoshina en-aut-mei=Eiko kn-aut-name=保科英子 kn-aut-sei=保科 kn-aut-mei=英子 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=4 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=5 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 en-keyword=QOL (quality of life) kn-keyword=QOL (quality of life) en-keyword=腎移植者 (renal transplant recipient) kn-keyword=腎移植者 (renal transplant recipient) en-keyword=健康状態 (health) kn-keyword=健康状態 (health) en-keyword=サポート (social support) kn-keyword=サポート (social support) en-keyword=看護的アプローチ (nursing approach) kn-keyword=看護的アプローチ (nursing approach) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=1 article-no= start-page=1 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20051225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Development of intramuscular probe for local muscle function kn-title=局所筋機能測定のための筋内挿入型プローブの開発 en-subtitle= kn-subtitle= en-abstract=In order to diagnose muscle function or dysfunction, surface/needle electromyograms, muscle biopsy, biochemical markers inspection, muscle tone, etc. are carried out. It is difficult to measure muscle function continuously by using these methods. In this study, an intramuscular probe and measurement system were developed. The probe is composed of optical fibers and six small platinum electrodes. The probe, the tip of which is protected by epoxy resin, is inserted in a cannula of 1.26mm in diameter. By using the fibers, the local blood flow in a muscle and the intramuscular pressure were measured. By using six electrodes (50μm in diameter), a motor unit action potential was measured. The time-course changes of the action potential, blood flow and intramuscular pressure were measured in the gastrocnemius muscle of rats under the resting and the local ischemia. The tibial nerve was stimulated electrically using the current of the unipolar and negative polarity with 50μs pulse duration every 2 seconds and the propagation velocity of the action potential was calculated from the potential waves. The animal tests using rats were carried out in order to verify the developed probe and system. Under the local ischemia, the action potential, the blood flow and the intramuscular pressure decreased and the propagation velocity became slower. When dantrolene sodium was injected, which inhibits the calcium release channel of the sarcoplasmic reticulum, the intramuscular pressure decreased but the action potential wave was still detectable. kn-abstract=臨床においては,筋機能や機能不全を診断するために,表面筋電図や針筋電図,筋生検などが行われている｡しかし,これらの方法では筋機能や筋収縮メカニズムを連続的に測定することは難しい｡本研究では新たに筋内挿入型プローブと測定システムを開発した｡測定プローブは光ファイバと6本の白金細線から構成されている｡光ファイバを用いて筋の局所血流量と筋内圧力を測定し,6個の電極を用いて運動単位活動電位を測定した｡プローブと測定システムの基礎特性を確認した後,麻酔下のラットの排腹筋において,安静時および局所虚血時の活動電位,血流量,筋内圧力を測定した｡また脛骨神経を電気刺激し,活動電位波形から伝播速度を算出したところ,プローブは正常に動作していることが確認できた｡さらに筋小胞体からのカルシウム放出チャネルを抑制するdantroleneを筋注すると,筋内圧力波形は大きく減少したが,活動電位波形はほとんど変化しないことがわかった｡ en-copyright= kn-copyright= en-aut-name=OkaHisao en-aut-sei=Oka en-aut-mei=Hisao kn-aut-name=岡久雄 kn-aut-sei=岡 kn-aut-mei=久雄 aut-affil-num=1 ORCID= en-aut-name=EdamatsuMotonari en-aut-sei=Edamatsu en-aut-mei=Motonari kn-aut-name=枝松幹也 kn-aut-sei=枝松 kn-aut-mei=幹也 aut-affil-num=2 ORCID= en-aut-name=WatanabeShogo en-aut-sei=Watanabe en-aut-mei=Shogo kn-aut-name=渡辺彰吾 kn-aut-sei=渡辺 kn-aut-mei=彰吾 aut-affil-num=3 ORCID= en-aut-name=KitawakiTomoki en-aut-sei=Kitawaki en-aut-mei=Tomoki kn-aut-name=北脇知己 kn-aut-sei=北脇 kn-aut-mei=知己 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部保健学科検査技術科学専攻 affil-num=2 en-affil= kn-affil=朝日インテック株式会社 affil-num=3 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=4 en-affil= kn-affil=岡山大学医学部保健学科検査技術科学専攻 en-keyword=筋機能 (muscle function) kn-keyword=筋機能 (muscle function) en-keyword=筋内圧力 (intramuscular pressure) kn-keyword=筋内圧力 (intramuscular pressure) en-keyword=筋内血流 (intramuscular blood flow) kn-keyword=筋内血流 (intramuscular blood flow) en-keyword=活動電位 (action potential) kn-keyword=活動電位 (action potential) en-keyword=筋収縮 (muscle contraction) kn-keyword=筋収縮 (muscle contraction) END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=3-4 article-no= start-page=287 end-page=297 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199004 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical and experimental studies on provocating and reducing mechanism of intractable pain Part 1. Experimental study on significance of changes of substance P and enkephalin concentrations in subnucleus caudalis of spinal trigeminal neucleus (STN) in cat kn-title=頑痛の発生および抑制に関する基礎的・臨床的研究　第1編　三叉神経脊髄路尾側亜核におけるサブスタンス P およびエンケファリン濃度変動の意義に関する基礎的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The possible role of substance P (SP) and enkephalin (ENK) was investigated in the mechanism of deafferented pain (DP) and excess pain. The concentration of SP anf ENK was quantitatively estimated with radioimmunoassay using 17 adults cats. The animal were divided into 3 group, DP group (8 cats), EP group (6 cats) and untreated conrol group (3 cats). The DP group was prepared according to the method described by Shimizu and EP model was made by injection 1 ml of Freund's adjuvant subcutaneously into the unilateral face of the cats every day for 3 weeks. The amount of SP in STN markedly decreased in DP group and significantly higher in EP group than with the control group. This is explained by the fact that SP is a neurotransmitter for pain of trigeminal nerve. No significant decrease in ENK in the DP group was observed. This suggests that ENK in STN is not always controlled by the descending inhibitory system, but may be working in the propriospinal system. ENK in the EP group also showed no significant increase. This can be explained not only by the difficulty in estimating the rapid degeneration of ENK, but also by the strong participation of monoamines as well as ENK in pain relief. The role of ENK should not be overstimated and the studies including monoamines will be necessary to detemine the mechanism of pain. en-copyright= kn-copyright= en-aut-name=FujiwaraNoriaki en-aut-sei=Fujiwara en-aut-mei=Noriaki kn-aut-name=藤原則章 kn-aut-sei=藤原 kn-aut-mei=則章 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳神経外科教室 en-keyword=substance P kn-keyword=substance P en-keyword=enkephalin kn-keyword=enkephalin en-keyword=pain kn-keyword=pain en-keyword=RIA kn-keyword=RIA END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=1-2 article-no= start-page=143 end-page=152 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Integration and expression of E1 region DNA in human adenovirus type 12-induced tumors kn-title=ヒトアデノウィルス12型誘発腫瘍におけるE1領域遺伝子の組み込みと発現 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Integration and expression of human adenovirus type 12 (Ad12) were studied on two Ad12-induced tumor lines of C3Hf/OK mouse origin (IC and D tumors). Southern hybridization using whole Ad12 genome as probe demonstrated that DNA of IC and D tumors contained about 9 and 23 copies, respectively, of the entire Ad12 genome eqivalent per diploid cell. Left ends of Ad12 DNA appeared as off-size bands, indicating their linkage to different cellular DNAs. Southern hybridization using and Ad12 EcoRI-C fragment containing the E1 region as a probe revealed that intergration sites were much fewer than presumen numbers of integrated Ad12 genones. These results suggested that the viral and cellular DNA complex was repeated at integration sites. Northen hybridization using an Ad12 EcoRI-C fragment as a probe showed that tha E1 region was transcribed in both IC and D tumors. Much more intensive expression in the D tumor suggested possible dependence of the expression of the E1 region on the copy numbers of Ad12 genomes. en-copyright= kn-copyright= en-aut-name=MorikawaTomoko en-aut-sei=Morikawa en-aut-mei=Tomoko kn-aut-name=森川智子 kn-aut-sei=森川 kn-aut-mei=智子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=香川医科大学病理学講座第一病理学 en-keyword=ヒトアデノウィルス12型 kn-keyword=ヒトアデノウィルス12型 en-keyword=E1領域 kn-keyword=E1領域 en-keyword=C3Hf/OK マウス kn-keyword=C3Hf/OK マウス en-keyword=ウィルス発癌 kn-keyword=ウィルス発癌 END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=1-2 article-no= start-page=77 end-page=86 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Changes of extravascular lung water after hepatic ischemia by Pringle's maneuver Part 2. In regard to the effect of clamping of the superior mesenteric artery or portofemoral vein bypass kn-title=Pringle 法急性肝流入血行遮断の肺血管外水分量におよぼす影響　第2編　上腸間膜動脈遮断と門脈一体循環シャント造設の効果を中心として en-subtitle= kn-subtitle= en-abstract= kn-abstract=To elucidate the effect of portal congestion on pulmonary interstitial edema after temporary hepatic ischemia by Pringle's maneuver, extravascular lung water (EVLW) was experimentally measured using a modified double indicator dilution method before and after interruption of the hepatic blood flow follwing clamping of the superior meaenteric artery or portofemoral vein bypass. The following results were obtained. 1) Compred with clamping of the superior mesenteric artery, the portofemoral vein bypass reduced the increase of EVLW after temporay hepatic ischemia by Pringle's maneuver. 2) The increase in EVLW had a tendency to be influenced by the degree of metabolic acidosis and portal congestion. These findngs suggest that the portofemoral vein bypass is more effective in the prolongation of the safe period of temporary hepatic ischemia by Pringle's maneuver than clamping of the superior mesenteric artery. en-copyright= kn-copyright= en-aut-name=YokoyamaNobuji en-aut-sei=Yokoyama en-aut-mei=Nobuji kn-aut-name=横山伸二 kn-aut-sei=横山 kn-aut-mei=伸二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=Pringle 法急性肝流入血行遮断 kn-keyword=Pringle 法急性肝流入血行遮断 en-keyword=肺血管外水分量 kn-keyword=肺血管外水分量 en-keyword=上腸間膜動脈遮断 kn-keyword=上腸間膜動脈遮断 en-keyword=門脈一体循環シャント kn-keyword=門脈一体循環シャント END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=11-12 article-no= start-page=1215 end-page=1224 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immobilization of denitrifying bacteria using photo-crosslinkable resin prepolymer and some of its properties kn-title=光硬化性樹脂プレポリマーを用いる脱窒菌の固定化に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The denitrifiers isolated from the activated sludge of night soil treatment plant were immobilized using a photo-crosslinkable resin prepolymer. Denitrifying activity was strongly inhibited during the first period but the activity was increased in the medium containing nitrate and recovered after 1 day. Acetate was an effective hydrogen source and soap was also effective. Methanol could not serve as a hydrogen source. The optimum pH for denitrification by the immobilized bacteria was 7.0 for nitrite and 7.5 for nitrate, and the optimum temperature ranged 30℃ to 40℃. The lowest CH3COONa/NOx-N ratio nessary for getting the highest activity was 4 for nitrite (BOD/NO2-N＝2) and 5 for nitrate (BOD/NO3-N＝2.5). Photo-crosslinkable resin prepolymer gels exhibited stable denitrification activity to the secondarily treated sewage contained 70mg/l of soap. en-copyright= kn-copyright= en-aut-name=ItadaniTsutomu en-aut-sei=Itadani en-aut-mei=Tsutomu kn-aut-name=板谷勉 kn-aut-sei=板谷 kn-aut-mei=勉 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部細菌学教室 en-keyword=脱窒菌 kn-keyword=脱窒菌 en-keyword=固定化 kn-keyword=固定化 en-keyword=脱窒素 kn-keyword=脱窒素 en-keyword=排水処理 kn-keyword=排水処理 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=11-12 article-no= start-page=1207 end-page=1214 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Basic study on nitrification and the BOD removal of the sewage using immobilized activated sludge kn-title=固定化活性汚泥を用いる排水処理実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Activated sludge obtained from the night soil treatment plant was immobilized using acrylamide and nitrification and the BOD removal of the sewage were studied by using the immobilized activated sludge which was packed in a single treatment tank. The findings indicated that the ratio of nitrification in the immobilized gel tank was larger than that in the free activated sludge tank in every operation period, and the rate of BOD removal in the immobilized gel tank was roughly equal to that in the free activated sludge tank in this condition. The findings indicated that the application of immobilized activated sludge to the sewage treatment enabled the sewage treatment process to be more efficiency and compact. en-copyright= kn-copyright= en-aut-name=ItadaniTsutomu en-aut-sei=Itadani en-aut-mei=Tsutomu kn-aut-name=板谷勉 kn-aut-sei=板谷 kn-aut-mei=勉 aut-affil-num=1 ORCID= en-aut-name=HiraiYosikazu en-aut-sei=Hirai en-aut-mei=Yosikazu kn-aut-name=平井義一 kn-aut-sei=平井 kn-aut-mei=義一 aut-affil-num=2 ORCID= en-aut-name=KanemasaYasuhiro en-aut-sei=Kanemasa en-aut-mei=Yasuhiro kn-aut-name=金政泰弘 kn-aut-sei=金政 kn-aut-mei=泰弘 aut-affil-num=3 ORCID= en-aut-name=NagamachiEiko en-aut-sei=Nagamachi en-aut-mei=Eiko kn-aut-name=長町栄子 kn-aut-sei=長町 kn-aut-mei=栄子 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部細菌学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部細菌学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部細菌学教室 affil-num=4 en-affil= kn-affil=順正短期大学保健科 en-keyword=固定化活性汚泥 kn-keyword=固定化活性汚泥 en-keyword=固定化 kn-keyword=固定化 en-keyword=硝化 kn-keyword=硝化 en-keyword=排水処理 kn-keyword=排水処理 END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=1-2 article-no= start-page=63 end-page=76 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Changes of extravascular lung water after hepatic ischemia by Pringle's maneuver Part 1. In regard to the increase of the extravascular lunh water and its cause kn-title=Pringle 法急性肝流入血行遮断の肺血管外水分量におよぼす影響　第1編　肺血管外水分量の増加とその成因を中心として en-subtitle= kn-subtitle= en-abstract= kn-abstract=To elucidate the effect of total hepatic ischemia on pulmonary organs, extravascular lung water (EVLW) was experimentally measured using a modified double indicator dilution method before and after interruption of the hepatic blood flow using Pringle's maneuver. The follow-ing results were obtained : 1) EVLW was significantlly increased more than one hour after temporary total hepatic ischemia. 2) Temporary hypotension resulted in little increase of EVLW by removing and replacing some blood volume through the femoral artery. 3) Pumonary interstitial edema was histologically and maroscopically observed in the Pringle's maneuver group. 4) Marked metabolic acidosis and elevation of serum transaminase were revealed after temporary hepatic ischemia. These findings auggest that pulmonary interstitial edema may result from sfter temporary total hepatic ischemia by Pringle's maneuver and the changes of EVLW are caused by increased permeability due to liver injury, metabolic acidosis and portal congestion. en-copyright= kn-copyright= en-aut-name=YokoyamaNobuji en-aut-sei=Yokoyama en-aut-mei=Nobuji kn-aut-name=横山伸二 kn-aut-sei=横山 kn-aut-mei=伸二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=Pringle 法急性肝流入血行遮断 kn-keyword=Pringle 法急性肝流入血行遮断 en-keyword=肺血管外水分量 kn-keyword=肺血管外水分量 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=4 article-no= start-page=349 end-page=358 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of hypersensitivity pneumonitis Part 2. The examination of precipitating antibodies in patients with hypersensitivity pneumonitis kn-title=過敏性肺臓炎の病態に関する研究 第2編 過敏性肺臓炎患者における沈降抗体に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The presence of percipitating antibodies has been recognized to be essential for the diagnosis of hypersensitivity pneumonitis, although the mechanism of this antibody formation is still obscure. Precipitating antibodies were examined in patients with various respiratory disease including hypersensitivity pneumonitis. Patients with hypersensitivity pneumonitis had more precipitating antibodies than patients with bronchial asthma, PIE syndrome and other fibrotic lung diseases. Furthermore, asymptomatic family members of patients with hypersensitivity pneumonitis living in the same environment were shown to have few precipitating antibodies as a normal control. The presence of polluted air containing an antigen such as fungi is nescessary but not enough for the antibody formation. These findings suggest that the high responsiveness of the immune system of the respiratory tract would be important as well as the existance of contaminated air for the pathogenesis of hypersensitivity pneumonitis. en-copyright= kn-copyright= en-aut-name=MakimotoKoh en-aut-sei=Makimoto en-aut-mei=Koh kn-aut-name=槇本晃 kn-aut-sei=槇本 kn-aut-mei=晃 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=過敏性肺臓炎 kn-keyword=過敏性肺臓炎 en-keyword=吸入抗原 kn-keyword=吸入抗原 en-keyword=沈降抗体 kn-keyword=沈降抗体 en-keyword=HLA kn-keyword=HLA END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=1-2 article-no= start-page=7 end-page=22 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A study of pH dynamics in the distal esophagus by 24-hour esophageal pH monitoring in infants and children kn-title=小児における下部食道内pH動態の研究―24時間食道内pH monitoring による解析― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Twenty-four-hour esohageal pH monitoring in infants and children has been performed to clarify pH dynamics of the lower esophagus using a pH histogram and acid clearance value in addition to pH score. A pH histogram showing the total state of pH dynamics in the lower esophagus ia constructed with whole pH data obtained by 24-hour pH monitoring. An acid clearance value indication the clearance ability of the esophagus is calculated by pH curves. 1) The normal acid clearance value is under 100. 2) Lower-side-tail of the pH histograms has been analyzed with an acid clearance value and other parameters of gastric acid reflux into the esophagus. Several characteristic pH dynamics are observed in cases of apparently normal patterns and mild gastroesophageal reflux (GER) which were diagnosed by a conventional manner : (a) moderate reflux with good clearance ability, (b) prolonged running status between pH 3 and 4, and (c) mild and pathological reflux with impaired clearance cbility. 3) pH histograms of the GER type are divided into 2 subtypes : The flattened subtype, which indicates ture GER with incompetence of the lower esophageal sphincter (LES), and the peaked subtype, which is often observed in cases of hypertrophic pyloric stenosis and has a well-functioning LES without pathologic GER. en-copyright= kn-copyright= en-aut-name=WatanabeYasuhiro en-aut-sei=Watanabe en-aut-mei=Yasuhiro kn-aut-name=渡辺泰宏 kn-aut-sei=渡辺 kn-aut-mei=泰宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=香川医学大学小児外科学教室 en-keyword=gastroesophageal reflux kn-keyword=gastroesophageal reflux en-keyword=pH monitoring acid clearance kn-keyword=pH monitoring acid clearance en-keyword=lower esophageal sphincter kn-keyword=lower esophageal sphincter END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=4 article-no= start-page=257 end-page=266 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effects of SMA-SOD on brain damage induced by complete global brain ischemia in dogs kn-title=イヌの完全全脳虚血後の脳障害に及ぼすSMA-SOD の効果に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effects of stylene maleinic acid butyl ester superoxide dismutase (SMA-SOD) on the brain damage induced by ischemia were studied in dogs. Eighteen minutes of cerebral ischemia was produced by clamping the ascending aorta with aorta-atrial and aorta-femoral vein bypass circuit. SMA-SOD(10mg/kg) was administered just after the initiation of recirculation. Dogs were divided into, control group and SMA-SOD group. In each group, cerebral blood flow (CBF) and intracranial pressure (ICP) were measured for 7 hours after ischemia, and neurologic outcome was evaluated up to 7 days after ischemia. Furthermore, extravasation of evans blue dye (EB, 100mg/kg) were observed 30 minutes after ischemia. SMA-SOD increased CBF during the hyperemia, and improved both delayed post-ischemic hypoperfusion (DHP) and neurologic outcomes. Extravasation of EB were recognized in the control group, but not in the SMA-SOD group. In conclusion, vasogenic edema might play a role in the elevation of ICP besides the hyperemia, and SMA-SOD improved neurologic outcome by prevention of edema, and improvement of DHP. Furthermore, free radicals might play a role in the appearance of ischemic brain damage. en-copyright= kn-copyright= en-aut-name=TakedaYoshimasa en-aut-sei=Takeda en-aut-mei=Yoshimasa kn-aut-name=武田吉正 kn-aut-sei=武田 kn-aut-mei=吉正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部麻酔・蘇生学教室 en-keyword=SMA-SOD kn-keyword=SMA-SOD en-keyword=神経学的予後 kn-keyword=神経学的予後 en-keyword=血流脳関門 kn-keyword=血流脳関門 en-keyword=遅発性脳血流減少 kn-keyword=遅発性脳血流減少 en-keyword=イヌ kn-keyword=イヌ END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=4 article-no= start-page=247 end-page=255 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Oncogene mRNA in gastric cancer by in situ hybridization by using a biotin-labeled probe kn-title=Biotin 標識 probe を用いた histo in situ hydridization 法による胃癌組織における癌遺伝子 mRNA の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Expression of oncogene mRNA in gastric cancer was studied by in situ hybridization. Cancer tissues were fixed in formalin and embeded in paraffin. Then, DNA-mRNA hybridization was performed by using two biotin-labeled cDNA probes (c-myc, c-Ha ras). Oncogene mRNA was intracuelularly localized, mainly in the cytoplasm, and also found in the nucleus of partial cells. Higher concentrations of oncogene mRNA vere found in advanced cancers than in early cancers, and in metastatic positive cases of the above n2 than of n0 or n1. This suggests that the expression of oncogene mRNA is related to the malignant potency of cancer. en-copyright= kn-copyright= en-aut-name=TanakaIzuru en-aut-sei=Tanaka en-aut-mei=Izuru kn-aut-name=田中出 kn-aut-sei=田中 kn-aut-mei=出 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=histo in situ hybridization 法 kn-keyword=histo in situ hybridization 法 en-keyword=胃癌 kn-keyword=胃癌 en-keyword=癌遺伝子 kn-keyword=癌遺伝子 en-keyword=ｍRNA kn-keyword=ｍRNA END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=1-2 article-no= start-page=183 end-page=197 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental study on pathogenesis and treatment of cerebral vasospasm Part 2. Effects of PGI2 analogue, thromboxane A2 synthetase inhibitor and Ca blocker on experimental delayed spasm models kn-title=脳血管攣縮の発生機序と治療に関する実験的研究 第2編 実験的遅発性脳血管攣縮に対する PGI2 analogue, Thromboxane A2 合成酵素阻害剤, Ca 拮抗剤の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effects of a PGI2 analogue (OP-41483), a thromboxane A2 synthetase inhibitor (OKY-046) and a Ca blocker (nifedipine) on the diameter of constricted basilar arteries and on the regional cerebral blood flow (r-CBF) in the brain stem were investigated in the cat delayed spasm model. The experiment was performed three days (72 hours) after artificial subarachnoid hemorrhage. The basilar artery was exposed transclivally, and more advanced vasospasm was produced by topical application of a lysed erythrocyte solution for 5 to 6 hours which domonstrated no more vascular dilatation even by topical application of papaverine hydrochloride (0.01mg/ml). In the delayed spasm model, the intravenous administration of neither OP-41483 (8μg/kg), OKY-046 (60mg/kg) nor nifedipine (0.003mg/kg) affected the vascular diameter. OP-41483 increased r-CBF in the brain stem in 3, and nifedipine increased it in 4 out of the 5 studied delayed spasm models, whereas OKY-046 never increased r-CBF (n=5). There was no significant difference in the amount of fatty acids including arachidonic acid between normal and constricted arteries. This study suggested that thromboxane A2 is not the major factor of cerebral vasospasm and OKY-046 might not be effective on vascular diameter or r-CBF at the late spasm stage. However, the PGI2 analogue (OP-41483) and Ca blocker (nifedipine) may be effective in increasing r-CBF even at the late spasm stage. en-copyright= kn-copyright= en-aut-name=MotokiMototsugu en-aut-sei=Motoki en-aut-mei=Mototsugu kn-aut-name=元木基嗣 kn-aut-sei=元木 kn-aut-mei=基嗣 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳神経外科教室 en-keyword=cerebral vasospasm kn-keyword=cerebral vasospasm en-keyword=thromboxane A2 kn-keyword=thromboxane A2 en-keyword=OP-41483 kn-keyword=OP-41483 en-keyword=OKY-046 kn-keyword=OKY-046 en-keyword=nifedipine kn-keyword=nifedipine END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=9-10 article-no= start-page=1075 end-page=1079 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical analysis of colorectal cancer with invasion to the adjacent organs kn-title=大腸癌他臓器浸潤症例の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The clinicopathologic features of 39 cases of colorectal cancer with invasion to the adjacent organs (si,ai) were studied. Twenty seven were cases with combined resection of involved organs. Twenty two and 17 cases were located in colon and rectum, respectively. The D region was mostly involved, followed by, the C and T region. Five cases had invasion to the gastrointestinal tract, 2 cases had invasion to the liver, gall bladder or pancreas. Twenty one cases had urogenital organ invasion and 11 cases had invasion to sacrum and other organs. The survival rate of cases with combined resection of the involved organs was significantly high compared with non-resection. Also, the survival rate of curative resection was significantly high compared with non-curative resection. Aggressive resection of involved organs seems to be important for good prognosis. en-copyright= kn-copyright= en-aut-name=ShiikiShigeo en-aut-sei=Shiiki en-aut-mei=Shigeo kn-aut-name=椎木滋雄 kn-aut-sei=椎木 kn-aut-mei=滋雄 aut-affil-num=1 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=2 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=3 ORCID= en-aut-name=HamadaFumihiro en-aut-sei=Hamada en-aut-mei=Fumihiro kn-aut-name=浜田史洋 kn-aut-sei=浜田 kn-aut-mei=史洋 aut-affil-num=4 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=5 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=大腸菌 kn-keyword=大腸菌 en-keyword=他臓器浸潤 kn-keyword=他臓器浸潤 en-keyword=他臓器合併切除 kn-keyword=他臓器合併切除 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=501 end-page=510 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The usefulness of ultrasongraphy in endometrial carcinoma : Particularly comparing transabdominal and transvaginal ultrasonography kn-title=子宮体癌に対する超音波断層法の有用性について―経腹走査と経腟走査の比較を中心に― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Between April, 1986 and March, 1991, 60 patients who underwent surgical treatment for endometrial carcinoma at the Department of Obstetrics and Gynecology, Okayama University Hospital, were preperatively examined by transvaginal ultrasonography (TV) and trans-abdominal ultrasonography (TA). The findings obtained were compared with the pathological findings to determine their usefulness in evaluating myometrial invasion and cervical invasion of endometrial carcinoma. Sensitvity of the lesion was 98.3% by TV and 80.0% by TA (p<0.01). Accuracy of the presence of myometrial invasion was 88.3% by TV and 70.0% by TA. Moreover, in evaluating the depth of myometrial invasion in three degrees (MO : Tumor limited to endometrium, M1 : Invasion to<1/2 myometrium, and M2 : Invasion >1/2 myometrium), the accuracy was 85.0% by TV and 61.7% by TA (p<0.01). In regard to the minimum width of the intact myometrium and the thickness of the high echoic area measured by each method, significant differences were obserevd between the M2-group and the other two group by the two methods. These p-values in TV were more significant than those in TA. In evaluating the presence of cervical invasion, the accuray was 95.0% by TV, while 88.3% by TA. Thus TV was found to be more useful than TA in the evaluation of both myometrial invasion and cerical invasion. en-copyright= kn-copyright= en-aut-name=TomokuniHirotaka en-aut-sei=Tomokuni en-aut-mei=Hirotaka kn-aut-name=友國弘敬 kn-aut-sei=友國 kn-aut-mei=弘敬 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産科婦人科学教室 en-keyword=子宮体癌 kn-keyword=子宮体癌 en-keyword=筋層浸潤 kn-keyword=筋層浸潤 en-keyword=頚部浸潤 kn-keyword=頚部浸潤 en-keyword=経腟走査 kn-keyword=経腟走査 en-keyword=超音波断層法 kn-keyword=超音波断層法 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=1-2 article-no= start-page=77 end-page=84 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A comparison of reactive hyperemic response in the right and left coronary arteries kn-title=右冠動脈反応性充血の検討―左冠動脈との比較― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Flow reserve of the right coronary artery (RCA) was studied in open-chest dogs and compared with that of the left anterior descending coronary artery (LAD). The maximum percent peak reactive hyperemia (％PRH) of the RCA was greater, and the duration of occlusion that produced one-half of the maximum coronary vasodilation (T1/2) in the RCA was about twice that in the LAD. With an increase in right ventricular MVO2 produced by construction of pulmonary artery or isoproterenol infusion, T1/2 of the RCA was shortened significantly. For estimating the quantitative contribution of the perfusion pressure to coronary flow reserve, we occluded the RCA for 60 sec and the LAD for 30 sec, during which each vessel reached maximum vasodilation with various perfusion pressure in the range of 100 to 20 mmHg. ％PRH decreased with a reduction in perfusion pressure, and perfusion pressure below which the RH abolished was significantly lower in the RCA than the LAD : 32.2±5.7 VS 41.5±5.0 mmHg. Thus, the RCA has a greater flow reserve than the LAD, and lower cardiac work and less extravascular artery compression of the right ventricle would account for this finding. en-copyright= kn-copyright= en-aut-name=WatanabeHirofumi en-aut-sei=Watanabe en-aut-mei=Hirofumi kn-aut-name=渡辺博史 kn-aut-sei=渡辺 kn-aut-mei=博史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 en-keyword=反応性充血 kn-keyword=反応性充血 en-keyword=自動調節能 kn-keyword=自動調節能 en-keyword=冠予備能 kn-keyword=冠予備能 en-keyword=右冠動脈 kn-keyword=右冠動脈 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=489 end-page=499 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The usefulness of transvaginal ultrasonography and MRI in endometrial carcinama : Evaluating myomertrial and cervical invasion kn-title=子宮体癌に対する経腟走査超音波断層法とMRIの有用性について―筋層浸潤と頚部浸潤の評価― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Between October, 1988 and March, 1991, twenty-mine patients with endometrial carcinoma bad both transvaginal ultrasonography (TVUS) and magnetic resonance imaging (MRI) performed following hysterectomy at the Departmetn of Gynecology and Obstetrics, Okayama University Medical School. The findings were compared with the pathological findings to determine the usefulness of each method. The sensitivity of dectecthing myometrial invasion was 100% by TVUS and 96% by MRI. The accuracy was 86% by each method. The depth of myometrial invasion was classified into 3 degrees [no myometrial invasion, superficial invasion (≤1/2), deep invasion (>1/2)]. The correct diagnostic rate was 86% by TVUS and MRI. The minimum width and the minimum/maximum width ratio of the intact myometrium obtained by each method in the pathological deep invasion group were significantly lower than those obtained in the other two groups (p<0.01). The sensitivity, the accuracy and the specificity of detecting cervical invasion were 89%, 93% and 95% by both methods. There was no difference between TVUS and MRI for diagnosing myometrial and cerical invasion of endometrial carcinoma. en-copyright= kn-copyright= en-aut-name=YoshiharaEisuke en-aut-sei=Yoshihara en-aut-mei=Eisuke kn-aut-name=吉原英介 kn-aut-sei=吉原 kn-aut-mei=英介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産科婦人科学教室 en-keyword=子宮体癌 kn-keyword=子宮体癌 en-keyword=経腟走査超音波断層法 kn-keyword=経腟走査超音波断層法 en-keyword=MRI kn-keyword=MRI en-keyword=筋層浸潤 kn-keyword=筋層浸潤 en-keyword=頚部浸潤 kn-keyword=頚部浸潤 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=1013 end-page=1018 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Lymph node metastases of right colon cancer kn-title=右側結腸癌に対するリンパ節郭清範囲の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The lymph node metastases of the right side colon were studied. Among 58 cases of right side colon, nodal involvements were found in 53.4%. Metastases to the epicolic and paracolic nodes were confined to an area within 10 cm from the tumor margin. Metastases to the intermediate nodes were found in 20.7% and metastases to the main nodes in 15.5%. Jumping metastases were recognized in 5 out of 31 cases of nodal involvement (16.1%). As the rate of jumping metastases is unexpectedly high, lymph node dissection for right colon cancer should be done as far as the main nodes. en-copyright= kn-copyright= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=1 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=2 ORCID= en-aut-name=HamadaFumihiro en-aut-sei=Hamada en-aut-mei=Fumihiro kn-aut-name=浜田史洋 kn-aut-sei=浜田 kn-aut-mei=史洋 aut-affil-num=3 ORCID= en-aut-name=ShiikiShigeo en-aut-sei=Shiiki en-aut-mei=Shigeo kn-aut-name=椎木滋雄 kn-aut-sei=椎木 kn-aut-mei=滋雄 aut-affil-num=4 ORCID= en-aut-name=MatsubaraNagahide en-aut-sei=Matsubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=5 ORCID= en-aut-name=AkazaiYoshihiro en-aut-sei=Akazai en-aut-mei=Yoshihiro kn-aut-name=赤在義浩 kn-aut-sei=赤在 kn-aut-mei=義浩 aut-affil-num=6 ORCID= en-aut-name=SuzakiKiichi en-aut-sei=Suzaki en-aut-mei=Kiichi kn-aut-name=須崎紀一 kn-aut-sei=須崎 kn-aut-mei=紀一 aut-affil-num=7 ORCID= en-aut-name=WatanabeTetsuya en-aut-sei=Watanabe en-aut-mei=Tetsuya kn-aut-name=渡辺哲也 kn-aut-sei=渡辺 kn-aut-mei=哲也 aut-affil-num=8 ORCID= en-aut-name=NonakaYasuyuki en-aut-sei=Nonaka en-aut-mei=Yasuyuki kn-aut-name=野中泰幸 kn-aut-sei=野中 kn-aut-mei=泰幸 aut-affil-num=9 ORCID= en-aut-name=KimuraToshikazu en-aut-sei=Kimura en-aut-mei=Toshikazu kn-aut-name=木村臣一 kn-aut-sei=木村 kn-aut-mei=臣一 aut-affil-num=10 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=11 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=右側結腸癌 kn-keyword=右側結腸癌 en-keyword=リンパ節転移率 kn-keyword=リンパ節転移率 en-keyword=跳躍転移 kn-keyword=跳躍転移 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=983 end-page=992 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of health examination program for 3 year old children : Follow-up study on screening of urine examination kn-title=三歳児健康診査の評価―検尿の意義と判定方法― en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study focuses on the health examination programs for 3 year old children from a public health point of view. The methodology, items tested, criteria and follow-up systems of urine examination were evaluated. Results of urine examinations of 8,615 children(male : 4,490, female : 4,125), who had been in the health examination program from 1980 to 1985, were studied in the area of K-ku in Y-city. Moreover a follow-up study was performed to discuss the significance of urine examination as mass screening. In the health examination program for 3 year old children, it is efficient to classify those with a score of more than “one plus” into the high risk group with regard to proteinuria and hematuria. It is possible to reduce the false positive rate by checking first morning urine at re-examination. A bettr information net work system must be established to utilize the results of mass health examinations for three year old children. en-copyright= kn-copyright= en-aut-name=TanakaKatsuko en-aut-sei=Tanaka en-aut-mei=Katsuko kn-aut-name=田中克子 kn-aut-sei=田中 kn-aut-mei=克子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部衛生学教室 en-keyword=3歳児健康診査 kn-keyword=3歳児健康診査 en-keyword=検尿 kn-keyword=検尿 en-keyword=健康診査の評価 kn-keyword=健康診査の評価 en-keyword=追跡調査 kn-keyword=追跡調査 en-keyword=学童健診 kn-keyword=学童健診 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=341 end-page=354 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Adequate antiplatelet therapy on the basis of individual variation in platelet aggregation in the late period after cardiovascular surgery kn-title=血小板凝集能の個体差を考慮した至適抗血小板療法―心臓血管外科手術後遠隔期における検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Platelet aggregation was studied on 670 samples of 20 healthy controls and 279 patients in the late period after cardiovascular surgery. Aggregating agents used were 0.5 and 2.0μM ADP as well as 2mM arachidonic acid (AA). Among the healthy controls, a maximum aggregation rate over 18% (ADP 0.5μM) was considered hyperaggregability, those under 47% (ADP 2μM) or under 78% (AA 2mM) consid-ered hypoaggregability. Maximun aggregation rate in patients not given antiplatelt agents widely varied from hyperaggregability to hypoaggregability. There was a positive correlation botween the first sample and the second one gained from each patient. This suggested that individual variation existed on platelet aggregation. Maximum aggregation rate significatly decreased by ticlopidine for ADP and by aspirin for AA. Both ADP and AA should be used for platelet aggregation. Comparison among three groups of different ticlopidine doses revealed that the doses should be decided on the basis of platelet aggregation for each patient. Thrombotic or hemorrhagic complications were observed in only 9 cases. Four of 7 cases of thrombotic complicatiion showed hyperaggregability and only 1 case showed hypoaggregability. Both cases of hemorrhagic complication showed hypoaggregability. These findings suggest that indication for antiplatelet therapy and doses of antiplatelet agent should be decided in consideration of individual variation on platelet aggregation. en-copyright= kn-copyright= en-aut-name=TsushimaYoshimasa en-aut-sei=Tsushima en-aut-mei=Yoshimasa kn-aut-name=津島義正 kn-aut-sei=津島 kn-aut-mei=義正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=血小板凝集能 kn-keyword=血小板凝集能 en-keyword=抗血小板薬 kn-keyword=抗血小板薬 en-keyword=ADP kn-keyword=ADP en-keyword=アラキドン酸 kn-keyword=アラキドン酸 en-keyword=術後遠隔期 kn-keyword=術後遠隔期 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=945 end-page=949 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Four cases of villous adenoma of rectum in our department : Comparative study of 88 cases of villous adenoma in Japan kn-title=直腸絨毛腺腫の4例―本邦報告88例についての検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=We reviewed the charts of 4 patients with villous adenoma of the rectum seen at the First Dept. of Surg., Okayama Univ. Med. School between 1971 and 1990. This study included 2 men and 2 women, ranging in age from 52 to 83 years. Polypectomy was performed on 3 patients with villous adenoma and low anterior resection was performed on 1 patient. Recurrent tumors developed in one of the 3 patients who had undergone polypectomy. In addition, a series of 88 patients with villous adenoma of the rectum reported in Japan were also reviewed. The average age of the patients with villous adenoma was 62.9. There were 47 men and 41 women. The presenting symptoms of the 69 patients with tumor were mainly bleeding and watery or mucinous diarrhea. The tumor size and invasiveness of malignancy were also examined. The likelihood of malignancy correlated with size of tumor, and none of the lesions smaller than 2cm contained a malignant tumor site. Surgeons should consider the size, location and malignant change of the villous tumor with as much precise examination before and during operation so that unnecessary over surgery is avoided. en-copyright= kn-copyright= en-aut-name=MatsubaraNagahide en-aut-sei=Matsubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=1 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=2 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=3 ORCID= en-aut-name=OokuraToshihiro en-aut-sei=Ookura en-aut-mei=Toshihiro kn-aut-name=大倉充博 kn-aut-sei=大倉 kn-aut-mei=充博 aut-affil-num=4 ORCID= en-aut-name=AkazaiYoshihiro en-aut-sei=Akazai en-aut-mei=Yoshihiro kn-aut-name=赤在義浩 kn-aut-sei=赤在 kn-aut-mei=義浩 aut-affil-num=5 ORCID= en-aut-name=WatanabeTetsuya en-aut-sei=Watanabe en-aut-mei=Tetsuya kn-aut-name=渡辺哲也 kn-aut-sei=渡辺 kn-aut-mei=哲也 aut-affil-num=6 ORCID= en-aut-name=SuzakiKiichi en-aut-sei=Suzaki en-aut-mei=Kiichi kn-aut-name=須崎紀一 kn-aut-sei=須崎 kn-aut-mei=紀一 aut-affil-num=7 ORCID= en-aut-name=YamashitaHiroshi en-aut-sei=Yamashita en-aut-mei=Hiroshi kn-aut-name=山下博士 kn-aut-sei=山下 kn-aut-mei=博士 aut-affil-num=8 ORCID= en-aut-name=HamadaFumihiro en-aut-sei=Hamada en-aut-mei=Fumihiro kn-aut-name=浜田史洋 kn-aut-sei=浜田 kn-aut-mei=史洋 aut-affil-num=9 ORCID= en-aut-name=GouchiAkira en-aut-sei=Gouchi en-aut-mei=Akira kn-aut-name=合地明 kn-aut-sei=合地 kn-aut-mei=明 aut-affil-num=10 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=11 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=直腸 kn-keyword=直腸 en-keyword=絨毛腺腫 kn-keyword=絨毛腺腫 en-keyword=癌化 kn-keyword=癌化 en-keyword=電解質異常 kn-keyword=電解質異常 END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue=1 article-no= start-page=21 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=環境教育に関する生徒の知識、意識、関心に関する調査研究―日本の普通科高校を例として― kn-title=A research on students knowledge, awareness and interest about environmental issues ; a case study at a high school in Japan en-subtitle= kn-subtitle= en-abstract=持続可能な開発と環境教育は世界的な課題であり、2002年のヨハネスブルク環境サミットでも議題として採り上げられ、特に教育によって持続可能な社会の発展を進めることが合意された。本研究は日本のある高校で1年間にわたって、土を題材とした単元を実施し、その事前事後に環境問題に関する調査を行い、生徒の環境に関する知識、意識、関心についてどのような水準にあり、授業によってどうかわるかを調査し、明らかにした。 kn-abstract=Education for Sustainable Development(ESD)-Environmental Education, has been a major concern at most UN summits. The 2002 Johannesburg Summit broadened the vision and re-affirmed the objective of the Millennium evelopment Goals (MDS) and proclaimed the Decade of Education for Sustainable Development for the period 2005-2014. This emphasized that education, is critical for promoting sustainable development and improving capacity of the people to address environment and development issues. This paper seeks to report, a finding on the level of student awareness and interests in environmental issues at a High School in Japan (a Super Science High School). A curricula unit was developed in the area of environmental education on soil. An actual chemistry class has been conducted in English. Pre & post lesson questionnaires were administered to the students. The result of the analysis indicates that, students are aware of environmental issues but need to be exposed to these issues in the form of activity-based classroom lessons. This we believe, will enable the students appreciate the fact that ESD is a life-wide and lifelong endeavor which challenges individuals, institutions and societies to view tomorrow as a day that belongs to all of us. This we presume is the main challenge of the MDS. en-copyright= kn-copyright= en-aut-name=AgubekoJulius Kofi en-aut-sei=Agubeko en-aut-mei=Julius Kofi kn-aut-name=アグベコジュリオス　コフィ kn-aut-sei=アグベコ kn-aut-mei=ジュリオス　コフィ aut-affil-num=1 ORCID= en-aut-name=NasuEtsuyo en-aut-sei=Nasu en-aut-mei=Etsuyo kn-aut-name=那須悦代 kn-aut-sei=那須 kn-aut-mei=悦代 aut-affil-num=2 ORCID= en-aut-name=KasaiTomomi en-aut-sei=Kasai en-aut-mei=Tomomi kn-aut-name=笠井智美 kn-aut-sei=笠井 kn-aut-mei=智美 aut-affil-num=3 ORCID= en-aut-name=WatanebeToshio en-aut-sei=Watanebe en-aut-mei=Toshio kn-aut-name=渡辺敏夫 kn-aut-sei=渡辺 kn-aut-mei=敏夫 aut-affil-num=4 ORCID= en-aut-name=EdagawaKazuko en-aut-sei=Edagawa en-aut-mei=Kazuko kn-aut-name=枝川和子 kn-aut-sei=枝川 kn-aut-mei=和子 aut-affil-num=5 ORCID= en-aut-name=KitaMasakazu en-aut-sei=Kita en-aut-mei=Masakazu kn-aut-name=喜多雅一 kn-aut-sei=喜多 kn-aut-mei=雅一 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院教育学研究科特別研究生 affil-num=2 en-affil= kn-affil=和歌山県立耐久高校 affil-num=3 en-affil= kn-affil=徳島県立城南高校 affil-num=4 en-affil= kn-affil=徳島県立城南高校 affil-num=5 en-affil= kn-affil=徳島県立城南高校 affil-num=6 en-affil= kn-affil=岡山大学教育学部 en-keyword=Environmental Education （環境教育） kn-keyword=Environmental Education （環境教育） en-keyword=Awareness (意識） kn-keyword=Awareness (意識） en-keyword=Students' interest (関心） kn-keyword=Students' interest (関心） en-keyword=Curriculum （環境教育カリキュラム） kn-keyword=Curriculum （環境教育カリキュラム） en-keyword=Soil kn-keyword=Soil END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=247 end-page=258 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental and clinical studies on interferon and its inducers Part 1. Effects of interferon and its inducers on neutrophil chemiluminescence kn-title=インターフェロン並びにインターフェロン誘発剤に関する基礎的・臨床的研究　第1編　インターフェロン並びにインターフェロン誘発剤の好中球 Chemiluminescence に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To evaluate one the effects of interferon (IFN) and its inducers on neutrophil functions neutrophil chemiluminescence (ChL) was assayed on 31 healthy individuals, nine patients treated with IFN-α (human lymphoblastoid interferon, 3×10(6)units/day i. m. daily) and 11 patients treated with Ge-132 (2,250mg/day p. o. daily). The base lines (BLs), peak levels (PLs) and times to PLs (PLs) of neutrophil ChL were examined before, one week and one month after the treatment. The direct effects of IFN-α, Ge-132 and OK-432 on neutrophil ChL were also evaluated by using an in vitro experimental system. PLs were significantly increased one week after the treatment with IFN-α or Ge-132. However, they were decreased to the pretreatment level one month after the treatment. In vitro experimental system IFN-α enhanced PLs of neutrophil ChL showing dose and time dependencies. On the other hand Ge-132 and OK-432 showed no direct effect on neutrophil ChL in vitro. These findings suggest that IFN-α and Ge-132 enhance the host defense mechanism by the activation of neutrophil functions, and also suggest that they have some benefits not only in the clinical management of cancer but also of chronic infection. en-copyright= kn-copyright= en-aut-name=FukumotoMitsuhiro en-aut-sei=Fukumoto en-aut-mei=Mitsuhiro kn-aut-name=福本光宏 kn-aut-sei=福本 kn-aut-mei=光宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Interferon kn-keyword=Interferon en-keyword=Ge-132 kn-keyword=Ge-132 en-keyword=Ok-143 kn-keyword=Ok-143 en-keyword=Neutrophil Chemiluminescence kn-keyword=Neutrophil Chemiluminescence END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Focal Adhesion KinaseとInsulin-like growth factor-I receptorに対するチロシンキナーゼ阻害剤の食道腺癌における抗腫瘍効果 kn-title=Dual-Tyrosine Kinase Inhibitor for Focal Adhesion Kinase and Insulin-like Growth Factor-I Receptor Exhibits Anticancer Effect in Esophageal Adenocarcinoma In vitro and In vivo en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeNobuyuki en-aut-sei=Watanabe en-aut-mei=Nobuyuki kn-aut-name=渡辺信之 kn-aut-sei=渡辺 kn-aut-mei=信之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=241 end-page=246 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effect of cyclosporin A on liver regeneration kn-title=肝再生に及ぼす Cyclosporin A の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=When lymphokine activiated killer cells (LAK cell) induced by IL-2 are infused into the same strain C(3)H mice following 70% partial hepatectomy, they display an action to suppress liver regeneration. Therefore, when Cyclosporin A (CsA) which inhibits IL-2 production was administerd to mice following partial hepatectomy, we studied as our indicator the labeling index of hepatic parenchyma cells using Brdu. Our findings showed that proliferation of live cells at 36 hours following partial hepatectomy was promoted by CsA, and the streongest promotion occuring at a dose of 5mg/kg. Before anf after hepatectomy when CsA was administered at 10mg/kg for 3 dadys, a further strong proliferation increasing effect was observed, and under these conditions at 48 and 60 hours after hepatectomy a significant increase in liver weight was observed. Give the above results, CsA it thought to have a promoting effect in liver regeneration following hepatectomy. en-copyright= kn-copyright= en-aut-name=YamamotoHiroshi en-aut-sei=Yamamoto en-aut-mei=Hiroshi kn-aut-name=山本浩史 kn-aut-sei=山本 kn-aut-mei=浩史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=Cyclosporin A kn-keyword=Cyclosporin A en-keyword=肝再生 kn-keyword=肝再生 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=11-12 article-no= start-page=1093 end-page=1105 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of guanidino compounds on monoamine oxidase and catechol-O-methyltransferase activity kn-title=モノアミン代謝酵素活性に及ぼすグアニジノ化合物の影響に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the central nervous system (CNS)of mammals, monoamine oxidase (EC 1.4.3.4)(MAO), which have been divided into two functional forms (MAO-A and MAO-B), and catechol-O-methyltransferase (EC 2.1.1.6)(COMT) act as catabolic enzymes of catecholamines and serotonin regulating their concentrations. In this study, the effects of guanidino compounds (5mM) on MAO-A, MAO-B and COMT were examined to invastigate the role of guanidino compounds in CNS function. MAO-A activity was decreased by α-guanidinoglutaric acid (GGA) and guanidinoethanesulfonic acid, and increased by arginine (Arg) and N-acetylarginine at a low substrate concentration (4.33μM). MAO-B activity was decreased by creatinine (CRN), δ-guanidinovaleric acid (GVA) and methylguanidine (MGua) at a high substrate concentration (3.125mM), and decreased by CRN, GVA, MGua, Arg, guanidine, 2-guanidinoethanol, β-guanidinopropionic acid, guanidinosuccinic acid and homoarginine at a low substrate concentration (62.5μM). GVA, CRN and MGua acted as competitive inhibitors on MAO-B and their calculated Ki values were 9.47mM, 14.5mM and 29.4mM, respectively. Although the guanidino compounds tested had no effect on COMT activity at a high substrate concentration (600μM), GSA and GVA inhibited COMT activity at a low substrate concentration (75μM). These results suggest that some guanidino compounds influence catabolic enzymes of indoleamine and catecholamines to control CNS function. en-copyright= kn-copyright= en-aut-name=HukuyamaKatsuhisa en-aut-sei=Hukuyama en-aut-mei=Katsuhisa kn-aut-name=福山勝久 kn-aut-sei=福山 kn-aut-mei=勝久 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属分子細胞医学研究施設神経情報学部門 en-keyword=guanidino compounds kn-keyword=guanidino compounds en-keyword=monoamine oxidase A kn-keyword=monoamine oxidase A en-keyword=monoamine oxidase B kn-keyword=monoamine oxidase B en-keyword=chatechol-O-methyltransferase kn-keyword=chatechol-O-methyltransferase END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=187 end-page=194 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An expert system for valvular heart disease using MRI and its clinical applications kn-title=心臓弁膜症のMR画像診断支援システムの開発とその臨床応用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=MRI is a valuable tool for diagnosing heart disease today. The cardiac blood flow is determined by an MRI image analysis and expert system. Image data are taken by a TV camera and digitalized. After gray level thresholding and region segmentation, the boundary of the regurgitant flow region is precisely extracted. Using this expert system, a doctor can easily make an accurate diagnosis of the valvular heart disease. This method should prove useful for the diagnosis of various heart diseases. en-copyright= kn-copyright= en-aut-name=NakagawaTomio en-aut-sei=Nakagawa en-aut-mei=Tomio kn-aut-name=中川富夫 kn-aut-sei=中川 kn-aut-mei=富夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 en-keyword=expert system kn-keyword=expert system en-keyword=MRI kn-keyword=MRI en-keyword=valvular heart disease kn-keyword=valvular heart disease END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=165 end-page=176 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Two useful indicators for the preoperative prediction of pulmonary and cardiac complications after lung resection kn-title=肺切除術における術後心肺合併症発生予測のための指数設定及びその臨床的有用性の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Two indicators (Risk score and Resection Index) for pulmonary and cardiac complications after lung resection were evaluated on 182 patients with bronchogenic carcinoma by quantita-tive technetium 99m macroaggregation albumin (MAA) perfusion scanning preoperatively and who then underwent lung resection. After surgerg, the correlations between preoperative lung function and the development of postoperative pulmonary and cardiac complications (PPCC) were examined in each case. The Risk score consisted of eight parameters (% FVC, FEV 1.0%, % MVV, % MMF, V50/HT, V25/HT, % peak flow, and % DLco), and a value of from 0 to 8 was assigned. In the patients with a Risk score of 0, PPCC occurred in 5 of the 71 cases, while complications were noted in 26 of the 94 patients with a Risk score from 1 to 5 and in 14 of the 17 patients with a score of over 6. The Resection Index was calculated from the predicted postoperative FEV 1.0 from the quantitative 99m Tc MAA perfusion scan and the predicted FEV 1.0, PPCC occurred in 20 of the 27 patients with a Resection Index of below 40%, 25 of the 131 patients with an index of 40% to 65%, and none of the 24 with an index over 65%. Both indicators had a good correlation with the occurrence of PPCC. These two indicators, the Risk score and the Resection Index, were clincally useful for predicting PPCC preoperatively and may help reduce the incidence of PPCC. en-copyright= kn-copyright= en-aut-name=KobashiYuichi en-aut-sei=Kobashi en-aut-mei=Yuichi kn-aut-name=小橋雄一 kn-aut-sei=小橋 kn-aut-mei=雄一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=肺癌 kn-keyword=肺癌 en-keyword=肺切除術 kn-keyword=肺切除術 en-keyword=術前肺機能 kn-keyword=術前肺機能 en-keyword=術後心肺合併症発生予測 kn-keyword=術後心肺合併症発生予測 en-keyword=肺血流シンチグラフィー kn-keyword=肺血流シンチグラフィー END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=83 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on laser photocoagulation for retinopathy of prematurity kn-title=レーザー光凝固による未熟児網膜症の治療に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Forty eyes in twenty-two cases in the active phase of retinopathy of prematurity were treated with laser photocagulation. Thiry (93.7%) of the 32 eyes in type I and intermediate type were found in the cicartrical phase grade 1. In type Ⅱ in which cryocautery was used as combination therapy, only 2 eyes (25.0%) were found in grade 1, 2 eyes (25.0%) in grade 2, 1 eye (12.5%) in grade 4 and 3 eyes (37.5%) in grade 5. All 21 eyes in which photocoagulation was performed up to the middle of stage 3 were found in grade 1 (100%). However, among 11 eyes in which photocoagulation were performed in late stage 3, 9 eys (81.8%) were found in grade 1, and 2 eyes (18.2%) in grade 2. In conclusion, if adequate laser photocoagulation is performed in avascular ares at the middle of stage 3 of type Ⅰ and intermediate type, treatment in cicartrical phase grade 1 is possible. Laser photocoagulation is clearly more effective than the xenon are photocoagula-tion or cryocautery. However, in type Ⅱ it is difficult to control the condition by photocagulation alone, and early diagnosis followed by combination therapy using cryocautery is reqired. en-copyright= kn-copyright= en-aut-name=OhtakiChiaki en-aut-sei=Ohtaki en-aut-mei=Chiaki kn-aut-name=大滝千秋 kn-aut-sei=大滝 kn-aut-mei=千秋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部眼科学教室 en-keyword=未熟児網膜症 kn-keyword=未熟児網膜症 en-keyword=レーザー光凝固 kn-keyword=レーザー光凝固 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=833 end-page=839 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A report of thirteen cases of familial polyposis coli kn-title=教室における家族性大腸ポリポーシス症例の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Familial polyposis coli (FPC) is an inherited nonsex linked mendelian dominant disease in which there exist at least 100 adenomatous polyps throughout the entire large bowel. Thirteen patients with FPC, of whom 7 were male and 6 female, visited our department between 1966 and 1990. The mean age of the patients was 33.5. Eight of the 13 patients (61.5%) had gastric and/or duodenal polyps, and eight of the 13 patients (61.5%) had colorectal carcinomas at admission. Colectomy with ileorectal anastomosis (IRA) was performed on 2 patients. The functional results were good bowel frequency, good sphincter control and lack of dietary restriction. Clinical experience tended to suggest that the risk of rectal cancer following IRA is extreme and unacceptable, although our two cases were still free of rectal cancer. Since 1980, the total colectomy with mucosal proctectomy and ileal pouch-anal anastomosis was the procedure of choice in our department. Good results were obtained on the six patients on whom this procedure was performed. en-copyright= kn-copyright= en-aut-name=WatanabeKazuhiko en-aut-sei=Watanabe en-aut-mei=Kazuhiko kn-aut-name=渡辺和彦 kn-aut-sei=渡辺 kn-aut-mei=和彦 aut-affil-num=1 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=2 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=3 ORCID= en-aut-name=ShiikiShigeo en-aut-sei=Shiiki en-aut-mei=Shigeo kn-aut-name=椎木滋雄 kn-aut-sei=椎木 kn-aut-mei=滋雄 aut-affil-num=4 ORCID= en-aut-name=MatubaraNagahide en-aut-sei=Matubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=5 ORCID= en-aut-name=AkazaiYoshihiro en-aut-sei=Akazai en-aut-mei=Yoshihiro kn-aut-name=赤在義浩 kn-aut-sei=赤在 kn-aut-mei=義浩 aut-affil-num=6 ORCID= en-aut-name=WatanabeTetsuya en-aut-sei=Watanabe en-aut-mei=Tetsuya kn-aut-name=渡辺哲也 kn-aut-sei=渡辺 kn-aut-mei=哲也 aut-affil-num=7 ORCID= en-aut-name=SuzakiKiichi en-aut-sei=Suzaki en-aut-mei=Kiichi kn-aut-name=須崎紀一 kn-aut-sei=須崎 kn-aut-mei=紀一 aut-affil-num=8 ORCID= en-aut-name=HamadaFumihiro en-aut-sei=Hamada en-aut-mei=Fumihiro kn-aut-name=浜田史洋 kn-aut-sei=浜田 kn-aut-mei=史洋 aut-affil-num=9 ORCID= en-aut-name=GouchiAkira en-aut-sei=Gouchi en-aut-mei=Akira kn-aut-name=合地明 kn-aut-sei=合地 kn-aut-mei=明 aut-affil-num=10 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=11 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=家族性大腸ポリポーシス kn-keyword=家族性大腸ポリポーシス en-keyword=胃・十二指腸ポリープ kn-keyword=胃・十二指腸ポリープ en-keyword=癌化 kn-keyword=癌化 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=9-10 article-no= start-page=885 end-page=895 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effect of nutritional intake on energy metabolism in postoperative patients after gastrointestinal surgery kn-title=間接熱量測定による消化器手術後のエネルギー代謝の検討―投与量･投与経路の比較― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Many studies have shown that enteral nutrition (EN) has nutritional effects comparable to total parenteral nutrition (TPN). However, the energy metabolism of the two different nutritioanl methods remains undefined. The two nutritional methods were compared by measuring the resting energy expenditure (REE) and nutritional assessment in postoperative patients after gastrointestinal surgery. The effects of different amounts of EN were also evaluated. Patients were diveded into three groups : Patients who were fed by EN of 30 Cal/kg/day (Group I, EN 30 : n=8), patients who were fed by EN of 40 Cal/kg/day (Group II, EN 40 : n=8), and patients who were fed by TPN of 30 Cal/kg/day (Group III, TPN : n=8). REE was measured by the Datex indirect calorimetry and nutritional assessment included the measurements of triceps skinfold thickness (TSF), arm muscle circumference (AMC), albumin and rapid turnover proteins. ％REE/BEE of EN30, EN40 and TPN was 122.5±14.3%, 138.2±16.8% and 107.6±10.5% respectively. The RQ for the three groups was about 1.0, which means the energy source of all regimens is carbohydrate. The TPN group showed a significantly higher RQ than the EN groups, but there was no difference in albumin or transferrin. There was no difference in nutritional effect between EN 30 and EN 40. No difference was found in anthropometric effects among the three groups. These findings suggest that 30 Cal/kg/day would be preferable to 40 Cal/kg/day in energy supply of enteral nutrition and that the energy expenditure of EN is higher than that of TPN under 30 Cal/kg/day nutrition. There is no difference among the three mehtods in terms of nutritional effects. en-copyright= kn-copyright= en-aut-name=YoshizaneKen en-aut-sei=Yoshizane en-aut-mei=Ken kn-aut-name=吉實憲 kn-aut-sei=吉實 kn-aut-mei=憲 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=間接熱量計 kn-keyword=間接熱量計 en-keyword=経腸栄養 kn-keyword=経腸栄養 en-keyword=経静脈栄養 kn-keyword=経静脈栄養 en-keyword=代謝熱量 kn-keyword=代謝熱量 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=63 end-page=74 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical and radiological study of femoral neck fractures in patients with rheumatoid arthritis kn-title=慢性関節リウマチ患者における大腿骨頸部骨折の臨床的ならびにX線学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clinical and radiological studies were performed on 58 patients with rheumatoid arthritis (RA) who had sustained 64 femoral neck fractures. All but one patietns werre female, the mean age was 66.5 years, and mean duration of RA was 17 years. Only 3 hips showed rheumatoid changes. Sixteen fractures of 14 patietns were spontaneous fractures without trauma. Ipsilateral total knee replacements were performed on 5 patients with spontaneous fractures. Results of treatment were analyzed on 47 fractures in 43 patients that could be followed up for more than 1 year (mean 42 months). Clinical results were evaluated by ability of ambula-tion and complications such as nonunion and avascular necrosis of the femoral head. All 4 fractures treated conservatively and 5 of 9 displaced fractures treated by internal fixation developed complications. Femoral head replacements had a high rate of proximal migration (23.8%) and distal migration (76.2%), and ambulation ability was lowered significantly in 10 patients with distal migration for more than 5 mm. On the other hand, satisfactory results were obtained on all 6 fractures treated by total hip replacements (THR). THR is advisable for tratmetn of displaced femoral neck fracture in patients with RA. en-copyright= kn-copyright= en-aut-name=KawamuraMasahide en-aut-sei=Kawamura en-aut-mei=Masahide kn-aut-name=川村正英 kn-aut-sei=川村 kn-aut-mei=正英 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部整形外科学教室 en-keyword=慢性関節リウマチ kn-keyword=慢性関節リウマチ en-keyword=大腿骨頸部骨折 kn-keyword=大腿骨頸部骨折 en-keyword=spontaneous fracture kn-keyword=spontaneous fracture en-keyword=治療成績 kn-keyword=治療成績 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=29 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The reconstructive surgery of head and neck cancers kn-title=頭頸部癌の再建外科―当科における再建術式の臨床的観察― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Thiry nine reconstructive surgeries were performed in 37 cases of head and neck cancers from January, 1989 to August, 1991 in our department. The best functional results were obtained on deglutition, swallowing and phonatin after intraoral and/or mesopharyngeal reconstruction using free radial forearm flaps. The free jejunal transposition procedure had the lowest complication rate. The rectus abdominus musculocutaneous free flap was used for nasal, paranasal reconstruction. Esthetics could be presereved by this reconstruction method due to mider postoperative atrophy and contraction. Eye sockets for the artificial eyes were made with eye conjunctiva in 3 canses of extended total maxillectomy with the orbital exenteration. The use of microvas-cular free flaps in this new plastic surgery resulted in the decrease of refusal of operations in maxillectomy canses. en-copyright= kn-copyright= en-aut-name=WatanabeShuichi en-aut-sei=Watanabe en-aut-mei=Shuichi kn-aut-name=渡辺周一 kn-aut-sei=渡辺 kn-aut-mei=周一 aut-affil-num=1 ORCID= en-aut-name=KawakamiTakashi en-aut-sei=Kawakami en-aut-mei=Takashi kn-aut-name=川上登史 kn-aut-sei=川上 kn-aut-mei=登史 aut-affil-num=2 ORCID= en-aut-name=InokuchiIkuo en-aut-sei=Inokuchi en-aut-mei=Ikuo kn-aut-name=井口郁雄 kn-aut-sei=井口 kn-aut-mei=郁雄 aut-affil-num=3 ORCID= en-aut-name=UnoKin-ya en-aut-sei=Uno en-aut-mei=Kin-ya kn-aut-name=宇野鉄哉 kn-aut-sei=宇野 kn-aut-mei=鉄哉 aut-affil-num=4 ORCID= en-aut-name=OhomichiTakuya en-aut-sei=Ohomichi en-aut-mei=Takuya kn-aut-name=大道卓也 kn-aut-sei=大道 kn-aut-mei=卓也 aut-affil-num=5 ORCID= en-aut-name=FukazawaMotoharu en-aut-sei=Fukazawa en-aut-mei=Motoharu kn-aut-name=深沢元晴 kn-aut-sei=深沢 kn-aut-mei=元晴 aut-affil-num=6 ORCID= en-aut-name=YonedaTakaaki en-aut-sei=Yoneda en-aut-mei=Takaaki kn-aut-name=米田孝明 kn-aut-sei=米田 kn-aut-mei=孝明 aut-affil-num=7 ORCID= en-aut-name=FukushimaKunihiro en-aut-sei=Fukushima en-aut-mei=Kunihiro kn-aut-name=福島邦博 kn-aut-sei=福島 kn-aut-mei=邦博 aut-affil-num=8 ORCID= en-aut-name=MasudaYu en-aut-sei=Masuda en-aut-mei=Yu kn-aut-name=増田游 kn-aut-sei=増田 kn-aut-mei=游 aut-affil-num=9 ORCID= en-aut-name=KamikawaYasuaki en-aut-sei=Kamikawa en-aut-mei=Yasuaki kn-aut-name=上川康明 kn-aut-sei=上川 kn-aut-mei=康明 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=再建外科 kn-keyword=再建外科 en-keyword=頭頸部癌 kn-keyword=頭頸部癌 en-keyword=有茎 (筋) 皮弁 kn-keyword=有茎 (筋) 皮弁 en-keyword=遊離 (筋) 皮弁 kn-keyword=遊離 (筋) 皮弁 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=21 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Antitumor effect of interferon-α, γ and/or tumor necrosis factor-α against human colon cancer line (LoVo) transplanted into nude mice kn-title=ヌードマウス可移植性ヒト大腸癌細胞株 LoVoに対する interferon-α,-γ, tumor necrosis factor-α の抗腫瘍効果の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We investigated the in vivo antitumor effect of recombinant human interferon-α,γ (IFN-α,γ) and/or recombinant human tumor necrosis factor-α (TNF-α) against human colon cancer cells (LoVo) transplanted into nude mice. LoVo cells were very sensitive to IFN-γ and slightly sensitive to IFN-α and resistant to TNF-α in vitro by dye uptake method. Intravenous administration of IFN-γ significantly inhibited tumor growth transplanted subcutaneously into nude mice, but IFN-α and/or TNF-α did not show any antitumor effect. Labeling index on stanining with bromodeoxyuridune and mitotic index of LoVo cells treated with IFN-α,γ or TNF-α differed slightly from those of the control group. We previously reported that the synergistic antitumor effects on the three cell lines could be examined by the combined use of IFN-α and TNF-α and the mechanism of the synergism was arrested in the S phase of cell cycle of target cells. However in the cese of LoVo cells, the combined use of IFN-α and TNF-α was not effective and did not arrest the cells in tha S phase of cell cycle. Therefore, arrest in the S phase was suspected to be responsible from the synergistic antitumor activity of IFN-α and TNF-α on the sensitive targets. en-copyright= kn-copyright= en-aut-name=KataokaKazuhiko en-aut-sei=Kataoka en-aut-mei=Kazuhiko kn-aut-name=片岡和彦 kn-aut-sei=片岡 kn-aut-mei=和彦 aut-affil-num=1 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=2 ORCID= en-aut-name=MuroMasahiko en-aut-sei=Muro en-aut-mei=Masahiko kn-aut-name=室雅彦 kn-aut-sei=室 kn-aut-mei=雅彦 aut-affil-num=3 ORCID= en-aut-name=KojimaKazushi en-aut-sei=Kojima en-aut-mei=Kazushi kn-aut-name=小島一志 kn-aut-sei=小島 kn-aut-mei=一志 aut-affil-num=4 ORCID= en-aut-name=HorikiSadayuki en-aut-sei=Horiki en-aut-mei=Sadayuki kn-aut-name=堀木貞幸 kn-aut-sei=堀木 kn-aut-mei=貞幸 aut-affil-num=5 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=6 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=7 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=nude mouse kn-keyword=nude mouse en-keyword=human colon cancer kn-keyword=human colon cancer en-keyword=interferon kn-keyword=interferon en-keyword=tumor necrosis factor kn-keyword=tumor necrosis factor en-keyword=cell cycle kn-keyword=cell cycle END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=663 end-page=668 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Senile diabetes mellitus complicated with celiac arterial obliteration and heaptocellular carinoma : A case report kn-title=腹腔動脈完全閉塞をきたした肝細胞癌合併高齢者糖尿病の興味ある一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report a 75-year-old female with diabetes mellitus complicated with celiac arterial obliteration and hepatocellular cercinoma (HCC). She had been treated with diet therapy by her family doctor for essential hypertension and diabetes mellitus and was referred to our hospital because a space occupying lesion (SOL) was detected in the liver by abdominal CT examination. The SOL was confirmed as hepatocellular carcinoma by ultrasonography and magnetic resoance imaging. Celiac angiography revealed complete obliteration of the celiac artery probably due to diabetic macroangiopathy. Sine the deterioration of the liver function was not conspicuous, it was suggested that the development of HCC was affected by diabetes mellitus. en-copyright= kn-copyright= en-aut-name=OkaTakahiko en-aut-sei=Oka en-aut-mei=Takahiko kn-aut-name=岡隆彦 kn-aut-sei=岡 kn-aut-mei=隆彦 aut-affil-num=1 ORCID= en-aut-name=TomodaJun en-aut-sei=Tomoda en-aut-mei=Jun kn-aut-name=友田純 kn-aut-sei=友田 kn-aut-mei=純 aut-affil-num=2 ORCID= en-aut-name=KobashiHaruhiko en-aut-sei=Kobashi en-aut-mei=Haruhiko kn-aut-name=小橋春彦 kn-aut-sei=小橋 kn-aut-mei=春彦 aut-affil-num=3 ORCID= en-aut-name=SakaiNobuyuki en-aut-sei=Sakai en-aut-mei=Nobuyuki kn-aut-name=坂井宣行 kn-aut-sei=坂井 kn-aut-mei=宣行 aut-affil-num=4 ORCID= en-aut-name=SakaguchiKohsaku en-aut-sei=Sakaguchi en-aut-mei=Kohsaku kn-aut-name=坂口孝作 kn-aut-sei=坂口 kn-aut-mei=孝作 aut-affil-num=5 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name=山本和秀 kn-aut-sei=山本 kn-aut-mei=和秀 aut-affil-num=6 ORCID= en-aut-name=HigashiToshihiro en-aut-sei=Higashi en-aut-mei=Toshihiro kn-aut-name=東俊宏 kn-aut-sei=東 kn-aut-mei=俊宏 aut-affil-num=7 ORCID= en-aut-name=ItoToshio en-aut-sei=Ito en-aut-mei=Toshio kn-aut-name=伊藤俊雄 kn-aut-sei=伊藤 kn-aut-mei=俊雄 aut-affil-num=8 ORCID= en-aut-name=YamadaGotaro en-aut-sei=Yamada en-aut-mei=Gotaro kn-aut-name=山田剛太郎 kn-aut-sei=山田 kn-aut-mei=剛太郎 aut-affil-num=9 ORCID= en-aut-name=TsujiTakao en-aut-sei=Tsuji en-aut-mei=Takao kn-aut-name=辻孝夫 kn-aut-sei=辻 kn-aut-mei=孝夫 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一内科学教室 en-keyword=糖尿病 kn-keyword=糖尿病 en-keyword=腹腔動脈閉塞 kn-keyword=腹腔動脈閉塞 en-keyword=肝細胞癌 kn-keyword=肝細胞癌 en-keyword=動脈硬化 kn-keyword=動脈硬化 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=655 end-page=661 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Maintenance therapy with erythropoietin for renal anemia kn-title=腎性貧血に対するエリスロポエチンの維持投与法の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The beneficial effect of recombinant human erythropoietin (EPO) for renal anemia in patients with chronic hemodialysis has been esthablishel. EPO is reported to be effective against renal anemia when adeministered at a dose 3,000 units three times a week. However, only a few studies have been made on the therapy to maintain the anemia-improving effect of EPO. In the present study, we performed EPO maintenance therapy on 22 hemodialysis patients with renal anemia. EPO was initialy administered at a dose of 3,000 units three times a week, and maintenance therapy was initiated after 12 weeks of treatment. The patients were divided into two groups, with EPO being administered at a dose of 1,500 units twice a week to one group and three times a week to the other. The duration of maintenance therapy was set at eight weeks. The anemia-improving effect of EPO was found to be satisfactorily maintained in both groups and no significant difference was noted between them. According, it may be better to use the lower dose regimen of 1,500 units twice a week for the maintenance therapy of renal anemia. en-copyright= kn-copyright= en-aut-name=OguraTosio en-aut-sei=Ogura en-aut-mei=Tosio kn-aut-name=小倉俊郎 kn-aut-sei=小倉 kn-aut-mei=俊郎 aut-affil-num=1 ORCID= en-aut-name=NagakeYoshio en-aut-sei=Nagake en-aut-mei=Yoshio kn-aut-name=長宅芳男 kn-aut-sei=長宅 kn-aut-mei=芳男 aut-affil-num=2 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name=槇野博史 kn-aut-sei=槇野 kn-aut-mei=博史 aut-affil-num=3 ORCID= en-aut-name=HaramotoToshinori en-aut-sei=Haramoto en-aut-mei=Toshinori kn-aut-name=原本俊則 kn-aut-sei=原本 kn-aut-mei=俊則 aut-affil-num=4 ORCID= en-aut-name=MatsumotoMitsuhito en-aut-sei=Matsumoto en-aut-mei=Mitsuhito kn-aut-name=松本光仁 kn-aut-sei=松本 kn-aut-mei=光仁 aut-affil-num=5 ORCID= en-aut-name=HiramatsuMakoto en-aut-sei=Hiramatsu en-aut-mei=Makoto kn-aut-name=平松信 kn-aut-sei=平松 kn-aut-mei=信 aut-affil-num=6 ORCID= en-aut-name=MinoYasuaki en-aut-sei=Mino en-aut-mei=Yasuaki kn-aut-name=味埜泰明 kn-aut-sei=味埜 kn-aut-mei=泰明 aut-affil-num=7 ORCID= en-aut-name=NishimuraShigeaki en-aut-sei=Nishimura en-aut-mei=Shigeaki kn-aut-name=西村誠明 kn-aut-sei=西村 kn-aut-mei=誠明 aut-affil-num=8 ORCID= en-aut-name=TaniaiKazuhi en-aut-sei=Taniai en-aut-mei=Kazuhi kn-aut-name=谷合一陽 kn-aut-sei=谷合 kn-aut-mei=一陽 aut-affil-num=9 ORCID= en-aut-name=KumagaiIsao en-aut-sei=Kumagai en-aut-mei=Isao kn-aut-name=熊谷功 kn-aut-sei=熊谷 kn-aut-mei=功 aut-affil-num=10 ORCID= en-aut-name=KomotoKiichi en-aut-sei=Komoto en-aut-mei=Kiichi kn-aut-name=河本紀一 kn-aut-sei=河本 kn-aut-mei=紀一 aut-affil-num=11 ORCID= en-aut-name=TakehisaYoshiaki en-aut-sei=Takehisa en-aut-mei=Yoshiaki kn-aut-name=竹久義明 kn-aut-sei=竹久 kn-aut-mei=義明 aut-affil-num=12 ORCID= en-aut-name=MatsuuraUmeharu en-aut-sei=Matsuura en-aut-mei=Umeharu kn-aut-name=松浦梅春 kn-aut-sei=松浦 kn-aut-mei=梅春 aut-affil-num=13 ORCID= en-aut-name=SugaYoshihiko en-aut-sei=Suga en-aut-mei=Yoshihiko kn-aut-name=菅嘉彦 kn-aut-sei=菅 kn-aut-mei=嘉彦 aut-affil-num=14 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=5 en-affil= kn-affil=尾道市立市民病院内科 affil-num=6 en-affil= kn-affil=岡山済生会総合病院内科 affil-num=7 en-affil= kn-affil=落合病院内科 affil-num=8 en-affil= kn-affil=岡山中央病院内科 affil-num=9 en-affil= kn-affil=岡山中央病院内科 affil-num=10 en-affil= kn-affil=寺岡記念病院腎センター affil-num=11 en-affil= kn-affil=因島総合病院内科 affil-num=12 en-affil= kn-affil=鳥取市立病院内科 affil-num=13 en-affil= kn-affil=姫路第一病院内科 affil-num=14 en-affil= kn-affil=菅病院内科 affil-num=15 en-affil= kn-affil=岡山大学医学部第三内科学教室 en-keyword=腎性貧血 kn-keyword=腎性貧血 en-keyword=エリスロポエチン kn-keyword=エリスロポエチン en-keyword=維持投与法 kn-keyword=維持投与法 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=789 end-page=795 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The relationships between physique and throwing ability in high school baseball players kn-title=高校野球選手における形態と投能力の関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=There is little information on anthropometric measures (i. e., length, breadth and girth of body's parts) related to throwing ability. To clarify the influence of the physique on the throwing ability, the relationships between physique and throwing distance, as well as ball speed were investigated. The subjects were fourty-nine high school baseball players, and thirty-eight high school volleyball players, football players and canoeists served as a control group. The throwing distance was significantly related to lean body mass (r=.290), chest girth (r=.416), upper arm girth (r=.307), abdominal girth (r=.288), thigh girth (r=.327) and lower leg girth (r=.285) in baseball players group (p<0.05-0.01). A significant relationship between the throwing distance and foot length in control group (r=.329, p<0.05) was demonstrated. Significant relationships between ball speed and standing height in the baseball players group (r=.354, p<0.01) and that between ball speed and Impedance in the control group (r=-.288, p<0.05) were ovserved. These findings indicate that the throwing distance is influenced by quantity of body muscle in baseball players. There was no relation between physique and throwing ability in unskilled players. en-copyright= kn-copyright= en-aut-name=UchidaHayato en-aut-sei=Uchida en-aut-mei=Hayato kn-aut-name=内田勇人 kn-aut-sei=内田 kn-aut-mei=勇人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部衛生学教室 en-keyword=野球選手 kn-keyword=野球選手 en-keyword=形態 kn-keyword=形態 en-keyword=遠投距離 kn-keyword=遠投距離 en-keyword=ボールスピード kn-keyword=ボールスピード en-keyword=Impedance kn-keyword=Impedance END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=747 end-page=761 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Chemical and physiological changes of serum and thoracic-duct lymph in the dog with experimental obstructive jaundice and/or disorder of liver circulation kn-title=実験的閉塞性黄疸および肝循環障害における血清と胸管リンパ液組成の変動に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A long-term study on the chemical and physiological changes of serum and thoracic-duct lymph in the dog with a ligated common bile duct and/or artificial liver circulation was performed. The influencee of ligation of the common bile duct appeared earlier in the thoracic-duct lymph than in the serum. The portal pressure did not increase in the dog with a ligated common bile duct, but the lymph flow of the thoracic duct was 3 times that before ligation, which would prevent the rapid stagnation of bile pigment in the liver. The portal pressure was not elevated after ligation of the hepatic artery. The cholesterol level in the thoracic-duct lymph was about half of that in the serum. In the dog with ligature of the common bile duct, the serum total cholesterol level was elevated with the elevation of serum bilirubin, whereas that in the lymph of the thoracic duct was not elevated with the elevation of the bilirubin level in the lymph. These findings suggested that cholesterol would not easily enter into the lymphatic route. The serum GPT level increased during the first week after ligation of the hepatic artery, and decreased thereafter. However, after ligation of the common bile duct, the GPT level increased for several weeks after the first week of ligation. The pattern of GPT by both ligations seemed to be cross-crossed. The marked change in the total bilirubin level in the lymph of the thoracic duct suggested its close relation with the lymphatic system. It was proved possible to secure a tube into the thoracic duct for over three weeks by the use of a U-type connector and jacket-type plaster cast. en-copyright= kn-copyright= en-aut-name=UedaYuzo en-aut-sei=Ueda en-aut-mei=Yuzo kn-aut-name=上田祐造 kn-aut-sei=上田 kn-aut-mei=祐造 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=実験的肝障害 kn-keyword=実験的肝障害 en-keyword=閉塞性黄疸 kn-keyword=閉塞性黄疸 en-keyword=肝循環障害 kn-keyword=肝循環障害 en-keyword=胸管リンパ液 kn-keyword=胸管リンパ液 en-keyword=胸管カヌレーション kn-keyword=胸管カヌレーション END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=735 end-page=746 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the mechanism and treatment of intractable asthma Part 2. The mechanism of specific thromboxane A(2) synthetase inhibitor in cell-mediated allergy in intractable asthmatics kn-title=難治性喘息の病態と治療に関する研究　第2編　難治性喘息における細胞反応型アレルギーに対する選択的 Thromboxane A(2) 合成酵素阻害剤の抑制機序について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The specific thromboxane A(2) (TXA(2)) synthetase inhibitor (OKY-046) seems to be a useful drug in the treatment of intractable asthmatics. In this study, to clarify the action mechanism of OKY-046 and the relationship between TXA(2) and prostaglandin E(2) (PGE(2)) in cell-mediated allergy, the effect of the TXA(2) receptor antagonist (AA-2414), TXA2 analogue (STA(2)) and PGE(2) for peripheral blood mononuclear cells in adult intractable asthmatics was studied. OKY-046 significantly suppressed TXB(2) production and increased PGE(2) production from the peripheral blood mononuclear cells stimulated by PHA and Candida antigen, but AA-2414 had no effect. AA-2414 suppressed lymphocyte blastgenesis, but did not suppress significantly interleukin-2 (IL-2) or neutrophil chemotactic factor (NCF) production. Furthermore, STA(2) increased lymphocyte blastgenesis stimulated by Candida antigen partially, but not dose-dependently. On the other hand, PGE(2) suppressed significantly lymphocyte blastgenesis and IL-2 and NCF production in a dose-dependent manner. These findings suggest that the action mechanism of OKY-046 is a suppressive effect of cell-mediated allergy, and that TXA(2) and PGE(2) play an important role in the mechanism of intractable asthma. en-copyright= kn-copyright= en-aut-name=KanehiroArihiko en-aut-sei=Kanehiro en-aut-mei=Arihiko kn-aut-name=金廣有彦 kn-aut-sei=金廣 kn-aut-mei=有彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Intractable asthma kn-keyword=Intractable asthma en-keyword=thromboxane A(2) kn-keyword=thromboxane A(2) en-keyword=prostaglandin E(2) kn-keyword=prostaglandin E(2) en-keyword=thromboxane A(2) synthetase inhibitor (OKY-046) kn-keyword=thromboxane A(2) synthetase inhibitor (OKY-046) en-keyword=thromboxane A(2) receptor antagonist (AA-2414) kn-keyword=thromboxane A(2) receptor antagonist (AA-2414) END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=721 end-page=733 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the mechanism and treatment of intractable asthma Part 1. Effects of a specific thromboxane A(2) synthetase inhibitor in lymphocyte and neutrophil functions in intractable asthmatics kn-title=難治性喘息の病態と治療に関する研究　第1編　難治性喘息患者のリンパ球および好中球機能に及ぼす選択的 Thromboxane A(2) 合成酵素阻害剤の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify whether thromboxane A(2) (TXA(2)) is involved in type III and IV allergy, so-called "cell-mediated allergy", the effects of a specific TXA(2) synthetase inhibitor, sodium ozagrel (OKY-046) on peripheral blood mononuclear cells and neutrophils in adult intractable asthmatics were studied. Lymphocyte blastogenesis and interleukin-2 (IL-2) production from peripheral blood mononuclear cells stimulated by PHA and Candida antigen in intractable asthmatics was significantly suppressed dose-dependently by OKY-046. The neutrophil chemotactic factor (NCF) and eosinophil chemotactic factor (ECF) from peripheral blood nomonuclear cells stimulated by Candida antigen in intractable asthmatics tended to be suppressed by OKY-046. Furthermore, leukotriene C(4) (LTC(4)) and superoxide (O(2)(-)) production from peripheral blood neutrophils in intractable asthmatics was significantly suppressed dose-dependently by OKY-046. These findings suggest that TXA(2) plays an important role in the development of intractable asthma and OKY-046, which has a suppressive effect on type IV allergy caused by lymphocyte activation and on mediator release from neutrophils, might be a useful drug in the treatment of intractalbe asthmatics. en-copyright= kn-copyright= en-aut-name=KanehiroArihiko en-aut-sei=Kanehiro en-aut-mei=Arihiko kn-aut-name=金廣有彦 kn-aut-sei=金廣 kn-aut-mei=有彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Intractable asthma kn-keyword=Intractable asthma en-keyword=cell-mediated allergy kn-keyword=cell-mediated allergy en-keyword=thromboxane A(2) kn-keyword=thromboxane A(2) en-keyword=thromboxane A(2) synthetase inhibitor (OKY-046) kn-keyword=thromboxane A(2) synthetase inhibitor (OKY-046) END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=629 end-page=639 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of administration of inorganic fluorine on renal function in the rabbits kn-title=無機フッ素の腎に及ぼす影響に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It was previously reported that the elevation of inorganic fluorine level in plasma after inkalation of methoxyflurane causes acute renal failure. This study investigated whether the peak concentration or the duration of the inorganic fluorine is responsible for the real failure. Continuous infusion (5 millimols/liter and 10 millimols/liter) or a single intravenous bolus injection (720 millimols/liter) of sodium fluoride solution was adminstered to rabbits. The plasma concentration and the duration of the plasma fluorine was measured. There were no signs of pathological or biochemical changes that suggested renal failure when the peak plasma concentration was less than 50 millimols/liter for over 4 hours (5 millimols/liter, 24 hours), or whether peak concentration of plasma inorganic fliorine was over 50 millimols/liter for less than 4 hours (720 millimols/liter, intravenous bolus). However when 10 millimols/liter of sodium fluoride solution was administered at a speed of 10 milliliters/hour for 24 hours, the rabbits showed a peak plasma inorganic fluorine concentration over 50 micromols/liter for more than 4 hours and signs of renal failure developed ata plasma concentration of 65.8 micromols/liter 24 hours after the beginning of infusion. renal failure was mainly inthe form of edema of the tubular cells in both the cortex and medulla and abnormal biochemical changes (blood urea nitrogen 55.8±12.5 milligrams/deciliter, plasma creatinine 1.2±0.1 milligrams/deciliter). Inorganic fluorine can cause renal changes when its paek plasma concentration reaches more than 50 micromols/liter and lasts for more than 4 hours. en-copyright= kn-copyright= en-aut-name=YamamotoAtsuya en-aut-sei=Yamamoto en-aut-mei=Atsuya kn-aut-name=山本敦也 kn-aut-sei=山本 kn-aut-mei=敦也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部麻酔・蘇生学教室 en-keyword=無機フッ素 kn-keyword=無機フッ素 en-keyword=腎障害 kn-keyword=腎障害 en-keyword=揮発性吸入麻酔薬 kn-keyword=揮発性吸入麻酔薬 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=611 end-page=618 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Stusies on the pathogenesis in diffuse panbronchiolitis Part 1. Cellular components in bronchoalveolar lavage fluid of diffuse panbronchiolitis kn-title=びまん性汎細気管支炎の病態に関する研究　第1編　びまん性汎細気管支炎患者の気道細胞反応 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Diffuse panbronchiolitis (DPB) is known as a chronic progressive inflammation of the peripheral airway followed by lethal respiratory failure. Bronchoalveolar lavage (BAL) was performed to clarify the pathogenesis of DPB compared to chronic bronchitis. The recovery rate of BAL fluid in DPB decreased, but total cell count increased enormously. Furthermore, increased proportions of neutrophils in BAL fluid from DPB patients was characteristic and included a relative decrease in alveolar macrophages. Patients with DPB were classified based on the presence or absence chronic airway infection with Pseudomonas aeruginosa. There was no significant difference in cellular components of BAL fluid among the patients with or without Pseudomonas infection. Patients with DPB showed both obstructive and restrictive ventilatory disturbances. There was no correlation between parameters of these respiratory functions and total cell counts or various cellular proportions in BAL fluid. Infiltrating cell density around bronchioles of patients with DBP was measured. Significantly higher cell density was shown in patinets with DPB compared to other disease controls. There were also significant negative correlations between cell density and respiratory parameters such as % vital capacity, % V50 and % V25. These results indicate that remarkable increase in neutrophils in BAL fluid and the marked cell infiltration around bronchioles in DPB patients could play a crucial role in the pathogenesis of DPB. en-copyright= kn-copyright= en-aut-name=ShiraishiTakamasa en-aut-sei=Shiraishi en-aut-mei=Takamasa kn-aut-name=白石高昌 kn-aut-sei=白石 kn-aut-mei=高昌 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=びまん性汎細気管支炎 kn-keyword=びまん性汎細気管支炎 en-keyword=慢性気管支炎 kn-keyword=慢性気管支炎 en-keyword=気管支肺胞洗浄 kn-keyword=気管支肺胞洗浄 en-keyword=緑膿菌 kn-keyword=緑膿菌 en-keyword=細気管支領域細胞密度 kn-keyword=細気管支領域細胞密度 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=741 end-page=747 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Lateral lymph node metastasis of rectal carcinoma kn-title=教室における直腸癌側方リンパ節転移の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The records of 182 consecutive rectal carcinomas treated in this department between JAN 1978 and DEC 1990 were reviewed to assess the outcome of the patients presenting with lateral pelvic lymph node infiltration. Lateral lymph node dissection was carried out in 24 (42.1%) of the 57 Ra tumors and 63 (72.4%) of the 87 Rb tumors, but in none of the 38 cases of Rs tumors. Lymph node involvement was detected 0% and 15.9% of the Ra and Rb tumors, respectively. In this series, none of the cases in which the tumors were confined to m, sm and pm had positive lymph nodes. However, 23.3% of the 43 cases in which invasion was beyond pm showed positive lymph node invasion. The main lymph nodes involved were located in the roots of the middle rectal arteries. Half of the patients presented with distant metastases within one year, with poorer prognosis considering the mean survival rate of 1.8 years. In conclusion, we advocate that in Rb rectal tumors with circular invasion or invasion beyond the pm, careful lateral lymph nede dissection should be carried out. On the other hand, we suggest the use of preoperative radiation therapy which could improve the curability, the disease-free interval, and survival rates. en-copyright= kn-copyright= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=1 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=2 ORCID= en-aut-name=HamadaFumihiro en-aut-sei=Hamada en-aut-mei=Fumihiro kn-aut-name=浜田史洋 kn-aut-sei=浜田 kn-aut-mei=史洋 aut-affil-num=3 ORCID= en-aut-name=ShiikiShigeo en-aut-sei=Shiiki en-aut-mei=Shigeo kn-aut-name=椎木滋雄 kn-aut-sei=椎木 kn-aut-mei=滋雄 aut-affil-num=4 ORCID= en-aut-name=YasuiYoshimasa en-aut-sei=Yasui en-aut-mei=Yoshimasa kn-aut-name=安井義政 kn-aut-sei=安井 kn-aut-mei=義政 aut-affil-num=5 ORCID= en-aut-name=MatsubaraNagahide en-aut-sei=Matsubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=6 ORCID= en-aut-name=AkazaiYoshihiro en-aut-sei=Akazai en-aut-mei=Yoshihiro kn-aut-name=赤在義浩 kn-aut-sei=赤在 kn-aut-mei=義浩 aut-affil-num=7 ORCID= en-aut-name=WatanabeTetsuya en-aut-sei=Watanabe en-aut-mei=Tetsuya kn-aut-name=渡辺哲也 kn-aut-sei=渡辺 kn-aut-mei=哲也 aut-affil-num=8 ORCID= en-aut-name=GouchiAkira en-aut-sei=Gouchi en-aut-mei=Akira kn-aut-name=合地明 kn-aut-sei=合地 kn-aut-mei=明 aut-affil-num=9 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=10 ORCID= en-aut-name=KamikawaYasuaki en-aut-sei=Kamikawa en-aut-mei=Yasuaki kn-aut-name=上川康明 kn-aut-sei=上川 kn-aut-mei=康明 aut-affil-num=11 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=直腸癌 kn-keyword=直腸癌 en-keyword=側方郭清 kn-keyword=側方郭清 en-keyword=側方転移 kn-keyword=側方転移 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=539 end-page=547 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Mechanism of immunotherapy related to the production of antigen specific IgG subclass antibodies and leukotrienes in bronchial asthmatics kn-title=気管支喘息患者における減感作療法に作用機序に関する研究―抗原特異的IgGサブクラス抗体とロイコトリエン産生能に及ぼす影響について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the mechanism of immunotherapy in bronchial asthma, the level of mite specific IgG subclass asntibodies (total IgG, IgG(1), IgG(4)) and the production of leukotrienes (LTB(4), LTC(4)) released from leukocytes were examined. Eighteen mite-sensitive asthmatic patiens who received immunotherapy with house dust extract for 1 year were dividel into two groups, the responsive patients and non-responsive patients. Before treatment and 1 year after treatment, the levels of mite specific serum IgG subclass antibodies were measured by enzyme-linked immunosorbent assay (ELISA) and the levels of LTs were measured by high performance liquid chromatography (HPLC). In the responsive group, the level of mite specific serum IgG(4) antibody was significantly increased (p<0.05), and the level of mite specific serum total IgG and IgG(1) antibody was decreased. The release of LTB(4) and LTC(4) from leukocytes stimulated by mite antigen was significantly decreased (p<0.05,p<0.05). These results indicate that increases in the antigen specific IgG(4) and the inhibiton of chemical madiators play important roles in the mechanism of immunotherapy. en-copyright= kn-copyright= en-aut-name=KatagiSachie en-aut-sei=Katagi en-aut-mei=Sachie kn-aut-name=片木幸恵 kn-aut-sei=片木 kn-aut-mei=幸恵 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=immunotherapy kn-keyword=immunotherapy en-keyword=IgG subclass antibodies kn-keyword=IgG subclass antibodies en-keyword=leukotrienes kn-keyword=leukotrienes END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=11-12 article-no= start-page=1019 end-page=1030 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19931231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on chemotherapy for malignant lymphoma Part 2. Evaluation of anticancer drug combination on hematologic malignant cell lines using median effect analysis kn-title=悪性リンパ腫の化学療法に関する研究　第2編　血液腫瘍細胞に対する in vitro の薬剤併用効果：Median effect analysis による検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To establish an effective combination chemotherapy for hematologic malignancies, the combined effects of four anthracycline-anthraquinones and five other drugs were assessed in vitro. The anthracycline-anthraquinones were adriamycin (ADM), aclarubicin (ACR), THP-adriamycin (THP-ADM), mitoxantrone (MXT) and five other drugs were 4-hydroperoxycyclophosphamide (4HO(2)-CTX), cytarabine (Ara-C), vincristine (VCR), etoposide (ETP), cisplatin (CDDP). Median effect analysis presented by Chou and Talalay was used to assess the combined effects of these drugs on two cell lines (HL-60 and Raji). In addition, the ratio of maximal tolerable dose (MTD) to the dose that produced 50% growth inhibition (Dm) was calculated to estimate the clinical activity of each drug. Data of MTD/Dm indicated that THP-ADM and MXT might be clinically superior to ADM and ACR. The results of median effect analysis shown by a combination index were as follows : As to HL-60 cells that were derived from acute promyelocytic leukemia cells, synergistic effects were seen in the combination of ACR and Ara-C, THP-ADM and CDDP, MXT and 4HO2-CTX, MXT and Ara-C, MXT and VCR, MXT and ETP, indicating that MXT showed efficient synergistic effects when combined with other drugs. As to Raji cells that were derived from Burkitt's lymphoma cells, synergistic effects were observed in the combinations of ADM and ETP, ADM and CDDP, ACR and VCR,THP-ADM and VCR, THP-ADM and ETP, THP-ADM and CDDP, MXT and VCR, indicating that THP-ADM showed efficient synergistic effects when combined with other drugs. en-copyright= kn-copyright= en-aut-name=UenoKunio en-aut-sei=Ueno en-aut-mei=Kunio kn-aut-name=上野邦夫 kn-aut-sei=上野 kn-aut-mei=邦夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=median effect analysis kn-keyword=median effect analysis en-keyword=in vitro 薬剤併用効果 kn-keyword=in vitro 薬剤併用効果 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=527 end-page=541 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Regional cerebral blood flow in the patient with brain tumor kn-title=局所脳血流測定法による脳腫瘍の循環動態に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Regional cerebral blood flow (rCBF) was measured with xenon-enhanced CT(Xe-CT) in 21 cases of intracranial tumors (13 meningiomas, 5 gliomas, 3 metastatic brain tumors). Peritumoral edema was graded as mild, moderate or severe based on the extent of edema on CT and MRI. According to intratumoral blood flow distribution patterns, three patterns were classified as central type with relatively high blood flow at the center of the tumor, homogeneous type with an almost homegeneous blood flow distribution, and marginal type with relatively high blood flow at the periphery of the tumor. High grade astrocytoma and metastatic brain tumor showed marginal type blood flow and moderate or severe edema except in one case. Five meningiomas with severe peritumoral edema revealed marginal type blood flow and four with mild peritumoral edema showed central type blood flow, except for one cace. No correlation was found between the extent of peritumoral edema and histological subtype, tumor size, locaton, duration of clinical history, vascularization on angiogram, and mean blood flow in the tumor. These results suggest that blood flow distribution patterns within the tumor may affect the extension of peritumoral edema. Pre-and postoperative rCBFs were evaluated with Xe-CT and IMP-SPECT in 7 cases. mean rCBF of peritumoral edema was 6.2ml/100g/min preoperatively, and discrepancy between rCBF on Xe-CT and that on IMP-SPECT was shown in the remote cortical region ipsilateral to the tumor. Postoperative rCBF revealed an improved blood flow in both adjacent and remote areas, suggesting that the decreased blood flow associated with brain tumors might be relieved after surgery. en-copyright= kn-copyright= en-aut-name=TsuchidaShohei en-aut-sei=Tsuchida en-aut-mei=Shohei kn-aut-name=槌田昌平 kn-aut-sei=槌田 kn-aut-mei=昌平 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳神経外科学教室 en-keyword=brain tumor kn-keyword=brain tumor en-keyword=regional cerebral blood flow kn-keyword=regional cerebral blood flow en-keyword=SPECT kn-keyword=SPECT en-keyword=Xe-CT kn-keyword=Xe-CT END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=505 end-page=516 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on malignant lymphoma Part 2. Natural killer activity in patients with malignant lymphoma kn-title=悪性リンパ腫の病態と治療に関する研究　第2編　悪性リンパ腫における natural killer 活性の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The natural killer (NK) activity of peripheral blood mononuclear cells (PBMC) from patients with malignant lymphoma was examined. In 54 untreated patients, the mean NK activity did not differ significantly from that in healthy controls. However, 17 (31%) of 54 patients showed low NK activity. NK activity did not correlate with the stage, histologic type or patient age. Significant reduction of NK activity was observed during combination chemo-therapy. The mean NK activity in complete respondors (CRs) did not differ significantly from that in healthy controls. However, 5 (14%) of 37 patients who were disease-free for more than 3 years showed low NK activity. Low NK activity was frequently observed in long-term CRs with non-Hodgkin's lymphoma compared with negative PPD skin test, negative PHA skin test, low CD4/CD8 ratio and decreased response of PBMC to PHA and/or Con A. These results indicate that patients with malignant lymphoma have decreased immunity even while in long-term continuous remission and that measuring NK activity is useful for evaluating their immunologic status. en-copyright= kn-copyright= en-aut-name=TagawaShinya en-aut-sei=Tagawa en-aut-mei=Shinya kn-aut-name=田川真也 kn-aut-sei=田川 kn-aut-mei=真也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=lymphoma kn-keyword=lymphoma en-keyword=natural killer activity kn-keyword=natural killer activity en-keyword=immunity kn-keyword=immunity en-keyword=complete respondor kn-keyword=complete respondor en-keyword=chemotherapy kn-keyword=chemotherapy END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=499 end-page=512 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Correlation between left ventricular diastolic function before and after valve replacement surgery and myocardial ultrastructural changes in patients with left ventricular volume-overloaded valvular heart diseases : Evaluation with gated blood pool scintigraphy using (99m)Tc kn-title=左室容量負荷弁膜疾患の弁置換術前後における左室拡張能と心筋微細構造との関係―心プールシンチグラフｨーによる検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Left ventricular (LV) diastolic functions in 23 patients with aortic regurgitation (AR) and 22 patients with mitral regurgitation (MR) were evaluated by gated pool scintigraphy. LV myocardial biopsy was performed during open heart surgery, and LV myocardial ultrastructural chasges were evaluated by electron microscope. Correlation between LV diastolic function and myocardial ultrastructural change was examined. It was suggested that preoperative LV diastolic dysfunction occurred earlier than LV systolic dysfunction in patients with AR and MR. LV early diastolic dysfunction was especially significant in patients with AR. LV systolic function was significantly improved postoperatively compared with LV diastolic function in patients with AR and MR. It was suggested that LV interstitial fibrosis caused LV diastolic dysfunction in patients with AR and MR, and insufficiency of myocardial thickening as compensation in patients with MR. It was presumed that LV diastolic dysfunction was irreversilble in patients with AR and MR in the distant postoperative period due to persistence of the preoporative myocardial ultrastructural change, e.g, interstitial fibrosis. these LV diastolic indices measured by gated pool scintigraphy were useful in predicting LV ultrastructural changes and postoperative LV dysfunction in patients with LV volumeoverloaded valvular heart disease. en-copyright= kn-copyright= en-aut-name=OkadaTomiro en-aut-sei=Okada en-aut-mei=Tomiro kn-aut-name=岡田富朗 kn-aut-sei=岡田 kn-aut-mei=富朗 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=左室容量負荷弁膜疾患 kn-keyword=左室容量負荷弁膜疾患 en-keyword=左室拡張能 kn-keyword=左室拡張能 en-keyword=左室心筋微細構造 kn-keyword=左室心筋微細構造 en-keyword=心プールシンチグラフィー kn-keyword=心プールシンチグラフィー END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=493 end-page=503 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on malignant lymphoma Part 1. Second malignant neoplasms in patients with malignant lymphoma after chemotherapy kn-title=悪性リンパ腫の病態と治療に関する研究　第1編　悪性リンパ腫化学療法後の2次癌発症についての検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The risk of a second malignancy was analyzed in 23 patients with Hodgkin's disease (HD) and 177 with non-Hodgkin's lymphoma (NHL) who were initially treated with combination chemotherapy between 1976 and 1990. Among these patients, 3 cases of gastric cancer, 2 cases of lung cancer, 2 cases of hepatoma, one case of colon cnacer, one case of cholangiocarcinoma and one case of acute myeloblastic leukemia were subsequently observed. Median age at diagnosis of lymphoma was 64 years in patients who developed subsequent malignancies but was 9 years higher than that for the entire lymphoma group. Median interval from srart of chemotherapy to the appearance of second malignancy was 43.9 years and ranged from 1.9 years to 8.8 years. The 7-year cumulative risk of second malignancy in HD and NHL were 7.7% and 11.7%, respectively. In Hodgkin's disease, the incidence of stomach and lung cancers was significantly greater than expected incidence calculated on the basis of age-adjusted person-years. In non-Hodgkin's lymphoma, the incidence was also greater than expected for all malignancies except stomach cancer. This indicater that the incidence of solid malignancy as well as leukemia is higher in lymphoma patients after chemotherapy than in the general population. en-copyright= kn-copyright= en-aut-name=TagawaShinya en-aut-sei=Tagawa en-aut-mei=Shinya kn-aut-name=田川真也 kn-aut-sei=田川 kn-aut-mei=真也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=malignant lymphoma kn-keyword=malignant lymphoma en-keyword=chemotherapy kn-keyword=chemotherapy en-keyword=second primary malignancy kn-keyword=second primary malignancy END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=489 end-page=498 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical trial of enhancement method fro ultrasonographic diagnosis of thyroid nodules kn-title=結節性甲状腺腫の超音波診断における Enhancement 法の試み en-subtitle= kn-subtitle= en-abstract= kn-abstract=Enhancement in thyroid ultrasonography was investigated with thyroid lymphography by injection of Lipiodol into thyroid nodules in 50 patients. On plain thyroid ultrasonography (PU), the echo levels of normal and tumorous portions of the thyroid glands were evaluated. Then, the echo level ratios (P-N/T) were calculated. Moreover, by the same method, the echo level ratios between normal and tumorous portions of the thyroid glands were culculated 6 hours after Lipiodol injection (E-N/T), when the greatest enhancement was anticipated. The mean value of P-N/T was 1.305, and that of E-N/T was 1.474. The echo level ratio was significantly elevated in the enhancement method (p<0.0014). We concluded that the enhancement is obtained with Lipiodol injection into the normal portion of the thyroid glands, regardless of whether the tumor is benign or malignant and with or without cystic degeneration. This method is useful in promoting quality and location diagnosis of thyroid nodules. N : echo level value in the normal portion of thyroid gland T : echo level value in the tumorous portion of thyroid gland N/T : echo level raito en-copyright= kn-copyright= en-aut-name=TakeuchiRyuzo en-aut-sei=Takeuchi en-aut-mei=Ryuzo kn-aut-name=竹内龍三 kn-aut-sei=竹内 kn-aut-mei=龍三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=超音波診断 kn-keyword=超音波診断 en-keyword=結節性甲状腺腫 kn-keyword=結節性甲状腺腫 en-keyword=Enhancement kn-keyword=Enhancement en-keyword=甲状腺リンパ造影 kn-keyword=甲状腺リンパ造影 en-keyword=エコーレベル kn-keyword=エコーレベル END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=437 end-page=445 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on atypical leukemia Part 2. Clinical effects of low-dose (4)N-Behenoyl-β-D-Arabinofuranosylcytosine(BHAC) therapy on atypical leukemia kn-title=非定型的白血病の病態並びに治療に関する研究　第2編　非定型的白血病の治療に関する検討：(4)N-behenoyl-1-β-D-arabinofuranosyl-cytosine(BHAC) 少量療法の臨床効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Therapeutic effects of low-dose (4)N-Behenoyl-β-D-Arabinofuranosylcytosine(BHAC) on 52 patients with hypoplastic leukemia were analyzed to establish the optimal clinical management of hypoplastic leukemia. Among 8 patients treated with a low-dose (4)N-Behenoyl-β-D-Arabinofuranosyl cytosine (LD-BHAC) regimen, in which 50mg BHAC was administered daily intravenously by one-hour drip infusion for 14 days, 4 patients obtained complete remission (CR) and 2 patients obtained partial remission (PR). The response rate (CR+PR) was 75%. The responders were all over 65 years old. Although hematological toxicities and adverse effects on the digestive system such as anorexia and nausea were observed, they were all controllable by conventional treatments. The serum concentrations of ara-C were measured in 4 patients. Serum ara-C reached the peak concentration, 3.62-18.9 ng/ml (mean : 11.74 ng/ml), at the cessation of BHAC infusion, and a serum ara-C level of 2.75-4.89 ng/ml (mean : 3.54 ng/ml) was still present 6 hours after the cessation of infusion. Among 44 patients hospitalized before 1984, 27 patients were treated with blood transfusion and /or single antileukemic agent and 17 patients received combination chemotherapeutic regimens. Only 8 of 44 patients attained CR. The responders were all below 65 years old, and except for one patient, received combination chemotherapy. These results suggest that LD-BHAC therapy is useful in the clinical management of hypoplastic leukemia as a remission induction chemotherapy. en-copyright= kn-copyright= en-aut-name=NakadaHiroshi en-aut-sei=Nakada en-aut-mei=Hiroshi kn-aut-name=仲田浩之 kn-aut-sei=仲田 kn-aut-mei=浩之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=atypical leukemia kn-keyword=atypical leukemia en-keyword=therapy of hypoplastic leukemia kn-keyword=therapy of hypoplastic leukemia en-keyword=low dose behenoyl-ara-C therapy kn-keyword=low dose behenoyl-ara-C therapy en-keyword=behenoyl-ara-C kn-keyword=behenoyl-ara-C END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=415 end-page=428 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of the dynamic states of pulmonary ventilation and perfusion in bronchial asthmatics using (133)Xe gas ventilation scintigraphy and (99m)Tc-MAA lung perfusion scintigraphy kn-title=気管支喘息における換気血流動態の研究―(133)Xe換気シンチ及び(99m)Tc-MAA血流シンチによる検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the organic changes and pathophysiology of the lungs in intractable asthmatics, the dynamic states of pulmonary ventilation and perfusion were analyzed in 15 bronchial asthmatic in the stable state using (133)Xe gas ventilation scintigraphy and (99m)Tc-MAA lung perfusion scintigraphy, respectively. Dysfunction of pulmonary ventilation and impairment of pulmonary perfusin were significantly severer in intractable asthmatics than in non-intractable asthmatics (p<0.01, P<0.05, respectively) and those of asthma caused by aging. Late onset asthmatics with a long duration of disease tended to show severe impairment of pulmonary perfusion. Above all the longer the duration of the disease the severer became the impairment of pulmonary perfusion in late onset intractable asthmatics (LOIA). These findings suggest that the progression of irreversible organic changes of lungs in LOIA is involved in the severity of brochial asthma. en-copyright= kn-copyright= en-aut-name=IshihamaHidenobu en-aut-sei=Ishihama en-aut-mei=Hidenobu kn-aut-name=石濱英暢 kn-aut-sei=石濱 kn-aut-mei=英暢 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=中高年発症型難治性喘息 (LOIA) kn-keyword=中高年発症型難治性喘息 (LOIA) en-keyword=換気シンチ kn-keyword=換気シンチ en-keyword=血流シンチ kn-keyword=血流シンチ END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=401 end-page=413 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Kinetics of heat shock protein 72 in HeLa cells after treatment with heating and/or anticancer agents analyzed by a laser cytometer kn-title=レーザーサイトメーターを用いたheat shock protein 72の加温および抗癌剤添加による動態の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Heat shock proteins (HSPs) are regarded as the proteins most related to the development of thermotolerance. Recently, not only their role in thermotolerance, but also their role in resistance to anticancer agents is gathering concern. In this study, the kinetics of hsp 72 in HeLa cells treated with heating and/or anticancer agents were studied. Hsp 72 was immuno-stained by the indirect fluorescent technique using a monoclonal anti-hsp 72 antibody (Amer-sham). The staining pattern was observed and analyzed using a laser cytometer, ACAS 570 (Meridian). Hsp 72 was normally found in the cytoplasm at 37℃ and moved rapidly into the nucleus with heating at 43℃ for 2 hours. It then returned to the cytoplasm 4 to 6 hours after heating. The hsp 72 content reached a peak at 8 hours after heating. Hsp 72 was induced in all cells treated with cisplation, adriamycin, peplomycin, or etoposide for 48 hours. In the cells treated with both heating at 43℃ for 2 hours and these anticancer agents, hsp 72 induction was most suppressed by adriamycin. However, translocation of hsp 72 to the nucleus was specific for heating and was not affected by the anticancer agents. By laser cytometry the intracellular localization of hsp 72 and the changes of its content were simultaneously detected, Moreover, the change pattern of hsp 72 content measured by laser cytomtry coincided with that measured by the Western blotting procedure. en-copyright= kn-copyright= en-aut-name=SawaiHideaki en-aut-sei=Sawai en-aut-mei=Hideaki kn-aut-name=澤井秀秋 kn-aut-sei=澤井 kn-aut-mei=秀秋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産科婦人科学教室 en-keyword=レーザーサイトメーター kn-keyword=レーザーサイトメーター en-keyword=heat shock proteinｎ kn-keyword=heat shock proteinｎ en-keyword=抗癌剤 kn-keyword=抗癌剤 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=3-4 article-no= start-page=303 end-page=316 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Orthotopic liver transplantation in dogs : Post-operative changes in plasma-free amino acid levels and the meaning of these changes kn-title=同所性肝移植の実験的研究　肝移植手術における血漿遊離アミノ酸の変動とその意義について en-subtitle= kn-subtitle= en-abstract= kn-abstract=To determine the viability of livers after transplantation, three groups of experimental models were prepared (i. e., liver transplantation by the modified Starzl method ; hepatic cold-ischemia with cold ischemic time equal to transplantation time ; and simple laparotomy with sugar loading). Changes in plasma-free amino acid levels were investigated. The results showed an elevation of total amino acid levels in the early stage of a viable liver transplant. In addition, a decrease in the molar ratio of branched chain amino acids and aromatic amino acids was observed during the rejection period. The results also confirmed an increase in ornithine level, NH3, and ornithine carbamyl transferase as well as a decrease in the citrulline level, and unchanged arginine. A disturbance in the reaction in the urea cycle during the second stage was considered the cause. Among the plasma amino acids, alanine showed the greatest increase during the rejection period. This might be attributed to an acceleration in alanine release in the periphery, and an abnormal glucose-alanime cycle. As described above, examining changes in plasma-free amino acid levels may be an effective index of the viability of a liver transplant, both in the early stage and during the rejection poriod. en-copyright= kn-copyright= en-aut-name=MatsudaTadakazu en-aut-sei=Matsuda en-aut-mei=Tadakazu kn-aut-name=松田忠和 kn-aut-sei=松田 kn-aut-mei=忠和 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=同所性肝移植 kn-keyword=同所性肝移植 en-keyword=血漿中遊離アミノ酸 kn-keyword=血漿中遊離アミノ酸 en-keyword=拒絶反応 kn-keyword=拒絶反応 en-keyword=尿素回路 kn-keyword=尿素回路 en-keyword=Fischer 比 kn-keyword=Fischer 比 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=315 end-page=323 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the treatment of intractable asthman Part 2. Effect of Saiboku-to on lymphocyte function in the experimental asthma using guinea pigs kn-title=難治性喘息の治療に関する研究　第2編　モルモット喘息モデルにおけるリンパ球機能に対する柴朴湯の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Saiboku-to is a useful drug in the treatment of intractable asthmatics. The most important action mechanism of Saiboku-to seems to be a suppression on lymphocyte activation. The relationship between the in vitro and in vivo effects is not clear because the metabolism of Kampo medicine is unknown. Therefore, in this study two in vitro experimental systems were compared to evaluate the pharmacological effect of Saiboku-to on the lymphocyte blas-togenesis. The first system involved the addition of serum obtained from guinea pigs treated orally with Saiboku-to, while the second system involved the direct additon of the Saiboku-to extract to the medium. Saiboku-to has a suppressive effect on lymphocyte blastogenesis and also the metabolite of Saiboku-to had a suppressive effect. According to the formula based on these data, the serum level of Saiboku-to on oral administration of the common dose was assumed to be 5.65μg/ml in bronchial asthmatics. These findings suggest that Saiboku-to may an inhibitory effect in the cell-mediated allergic reaction by lymohocyte activation in vivo. en-copyright= kn-copyright= en-aut-name=OkamotoShoichi en-aut-sei=Okamoto en-aut-mei=Shoichi kn-aut-name=岡本章一 kn-aut-sei=岡本 kn-aut-mei=章一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Saiboku-to kn-keyword=Saiboku-to en-keyword=serum level kn-keyword=serum level en-keyword=actively sesitzed model kn-keyword=actively sesitzed model en-keyword=lymphocyte kn-keyword=lymphocyte END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=305 end-page=314 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the treatment of intractable asthman Part 1. Effect of Saiboku-to on cell-mediated allergy in the experimental asthma using guinea pigs kn-title=難治性喘息の治療に関する研究　第1編　モルモット喘息モデルにおける細胞反応型アルルギーに対する柴朴湯の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Saiboku-to seems to be a useful drug in the teatment of intractable asthmatics. The pharmacological effect of Saiboku-to was examined in an experimental model of bronchial asthma with cell-mediated allergy in guinea pigs. The fundings revealed that Saiboku-to inhibited the late asthmatic response. It suppressed the lymphocyte blastogensis by ascaris antigen and eosinophil infiltration into BALF and peribronchial tissue. Moreover, Saiboku-to lowered the levls of LTB4 and LTC4 in the cardiac blood, but not the antigen-specific IgG subclass. These findings suggest that the inhibitory effect of Saiboku-to on the late asthmatic response is caused by the suppression of cell-mediated allergy. en-copyright= kn-copyright= en-aut-name=OkamotoShoichi en-aut-sei=Okamoto en-aut-mei=Shoichi kn-aut-name=岡本章一 kn-aut-sei=岡本 kn-aut-mei=章一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Saiboku-to kn-keyword=Saiboku-to en-keyword=cell-mediated allergy kn-keyword=cell-mediated allergy en-keyword=actively sensitized model kn-keyword=actively sensitized model en-keyword=lymphocyte kn-keyword=lymphocyte en-keyword=leukotrienes kn-keyword=leukotrienes END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=299 end-page=304 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of broncholithiasis complicating hemoptysis kn-title=喀血を主訴に来院した気管支結石の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 62-year-old male was admitted because of hemoptysis. The chest X-ray showed an infiltrative shadow in the right upper lung field. Tomograms and CT scans also showed an infiltrative shadow and small calcifications in the same field. Examination by bronchoscopy revealed bronchial bleeding from the depth of the right B1b. Although the detailed view was unclear due to bleeding, we did not find any growth or any mucosal abnormality. We examined only the bronchial washing cytology. The result was Papanicolaou class Ⅱ. However, we could not rule out malignancy, so we decided to perform a right upper lobectomy. A bron-cholith was seen in the B1b and a hematoma was also seen on its periphery. The stone components were calcium carbonate (74%) and calcium phosphate (26%), suggesting that the stone was caused by mucus retention. en-copyright= kn-copyright= en-aut-name=IshiiYasunori en-aut-sei=Ishii en-aut-mei=Yasunori kn-aut-name=石井泰則 kn-aut-sei=石井 kn-aut-mei=泰則 aut-affil-num=1 ORCID= en-aut-name=InoueFumiyuki en-aut-sei=Inoue en-aut-mei=Fumiyuki kn-aut-name=井上文之 kn-aut-sei=井上 kn-aut-mei=文之 aut-affil-num=2 ORCID= en-aut-name=ShinRyuhan en-aut-sei=Shin en-aut-mei=Ryuhan kn-aut-name=慎隆範 kn-aut-sei=慎 kn-aut-mei=隆範 aut-affil-num=3 ORCID= en-aut-name=IshizukaShinji en-aut-sei=Ishizuka en-aut-mei=Shinji kn-aut-name=石塚真示 kn-aut-sei=石塚 kn-aut-mei=真示 aut-affil-num=4 ORCID= en-aut-name=FunakiNaoto en-aut-sei=Funaki en-aut-mei=Naoto kn-aut-name=舟木直人 kn-aut-sei=舟木 kn-aut-mei=直人 aut-affil-num=5 ORCID= en-aut-name=MuramatsuTomoyoshi en-aut-sei=Muramatsu en-aut-mei=Tomoyoshi kn-aut-name=村松友義 kn-aut-sei=村松 kn-aut-mei=友義 aut-affil-num=6 ORCID= en-aut-name=KamikawaYasuaki en-aut-sei=Kamikawa en-aut-mei=Yasuaki kn-aut-name=上川康明 kn-aut-sei=上川 kn-aut-mei=康明 aut-affil-num=7 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=8 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=9 ORCID= en-aut-name=OdaKoji en-aut-sei=Oda en-aut-mei=Koji kn-aut-name=小田晧二 kn-aut-sei=小田 kn-aut-mei=晧二 aut-affil-num=10 ORCID= en-aut-name=SeoKenji en-aut-sei=Seo en-aut-mei=Kenji kn-aut-name=瀬尾憲治 kn-aut-sei=瀬尾 kn-aut-mei=憲治 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=10 en-affil= kn-affil=小田病院外科 affil-num=11 en-affil= kn-affil=健照会セオ病院 en-keyword=気管支結石 kn-keyword=気管支結石 en-keyword=喀血 kn-keyword=喀血 en-keyword=Broncholithiasis kn-keyword=Broncholithiasis en-keyword=Hemoptysis kn-keyword=Hemoptysis END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=253 end-page=259 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Improvement of anemia by erythropoietin and changes in hemodialysis efficiency kn-title=エリスロポエチン投与による貧血改善と透析効率の変化に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The administration of recombinant human erythropoietin (EPO) has considerably improved renal anemia in benodialysis patients. However, there is a possibility that plasma flow will decrease and cause a reduction of hemodialysis effciency after the improvement of anemia. In the present study, we examined the influence of the improvement of anemia EPO administration on the efficiency of dialysis in 44 hemodialysis patients with renal anemia (21 males and 23 females ; mean age : 59.5±14.6 years). Epo was administered at a dose of 3,000 units three times a week and the duration of treatment was generally 12 weeks. EPO treatment significantly improved anemia. However, the blood urea nitrogen, creatinine, and uric acid levels before and after dialysis as well as the potassium and phosporus levels before dialysis showed no significant changes after the improvement of renal anemia. Accordingly. it is unnecessary to take any specific measures to improve the efficiency of dialysis after treating renal anemia with EPO. en-copyright= kn-copyright= en-aut-name=MakinoHirohumi en-aut-sei=Makino en-aut-mei=Hirohumi kn-aut-name=槇野博史 kn-aut-sei=槇野 kn-aut-mei=博史 aut-affil-num=1 ORCID= en-aut-name=NagakeYoshio en-aut-sei=Nagake en-aut-mei=Yoshio kn-aut-name=長宅芳男 kn-aut-sei=長宅 kn-aut-mei=芳男 aut-affil-num=2 ORCID= en-aut-name=OguraToshio en-aut-sei=Ogura en-aut-mei=Toshio kn-aut-name=小倉俊郎 kn-aut-sei=小倉 kn-aut-mei=俊郎 aut-affil-num=3 ORCID= en-aut-name=HaramotoToshinori en-aut-sei=Haramoto en-aut-mei=Toshinori kn-aut-name=原本俊則 kn-aut-sei=原本 kn-aut-mei=俊則 aut-affil-num=4 ORCID= en-aut-name=MatsumotoMitsuhito en-aut-sei=Matsumoto en-aut-mei=Mitsuhito kn-aut-name=松本光仁 kn-aut-sei=松本 kn-aut-mei=光仁 aut-affil-num=5 ORCID= en-aut-name=HaramatsuMakoto en-aut-sei=Haramatsu en-aut-mei=Makoto kn-aut-name=平松信 kn-aut-sei=平松 kn-aut-mei=信 aut-affil-num=6 ORCID= en-aut-name=MinoYasuaki en-aut-sei=Mino en-aut-mei=Yasuaki kn-aut-name=味埜泰明 kn-aut-sei=味埜 kn-aut-mei=泰明 aut-affil-num=7 ORCID= en-aut-name=NishimuraShigeaki en-aut-sei=Nishimura en-aut-mei=Shigeaki kn-aut-name=西村誠明 kn-aut-sei=西村 kn-aut-mei=誠明 aut-affil-num=8 ORCID= en-aut-name=TaniaiKazuhi en-aut-sei=Taniai en-aut-mei=Kazuhi kn-aut-name=谷合一陽 kn-aut-sei=谷合 kn-aut-mei=一陽 aut-affil-num=9 ORCID= en-aut-name=KumagaiIsao en-aut-sei=Kumagai en-aut-mei=Isao kn-aut-name=熊谷功 kn-aut-sei=熊谷 kn-aut-mei=功 aut-affil-num=10 ORCID= en-aut-name=KomotoKiichi en-aut-sei=Komoto en-aut-mei=Kiichi kn-aut-name=河本紀一 kn-aut-sei=河本 kn-aut-mei=紀一 aut-affil-num=11 ORCID= en-aut-name=TakehisaYoshiaki en-aut-sei=Takehisa en-aut-mei=Yoshiaki kn-aut-name=竹久義明 kn-aut-sei=竹久 kn-aut-mei=義明 aut-affil-num=12 ORCID= en-aut-name=MatsuuraUmeharu en-aut-sei=Matsuura en-aut-mei=Umeharu kn-aut-name=松浦梅春 kn-aut-sei=松浦 kn-aut-mei=梅春 aut-affil-num=13 ORCID= en-aut-name=SugaYoshihiko en-aut-sei=Suga en-aut-mei=Yoshihiko kn-aut-name=菅嘉彦 kn-aut-sei=菅 kn-aut-mei=嘉彦 aut-affil-num=14 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=5 en-affil= kn-affil=尾道市立市民病院内科 affil-num=6 en-affil= kn-affil=岡山済生会総合病院内科 affil-num=7 en-affil= kn-affil=落合病院内科 affil-num=8 en-affil= kn-affil=岡山中央病院内科 affil-num=9 en-affil= kn-affil=岡山中央病院内科 affil-num=10 en-affil= kn-affil=寺岡記念病院腎センター affil-num=11 en-affil= kn-affil=因島総合病院内科 affil-num=12 en-affil= kn-affil=鳥取市立病院内科 affil-num=13 en-affil= kn-affil=姫路第一病院内科 affil-num=14 en-affil= kn-affil=菅病院内科 affil-num=15 en-affil= kn-affil=岡山大学医学部第三内科学教室 en-keyword=腎性貧血 kn-keyword=腎性貧血 en-keyword=エリスロポエチン kn-keyword=エリスロポエチン en-keyword=透析効率 kn-keyword=透析効率 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=239 end-page=252 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Regional left ventricular contractile dynamics in hypertrophic cardimyopathy estimated by magnetic resonance imaging kn-title=MRIによる肥大型心筋症の局所左室壁収縮動態の評価 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To assess the regional myocardial function in hypertrophic cardiomyopathy (HCM), I examined the systolic wall thickening (% WT) and percent change of segmental wall area (% AR) using cine magnetic resonance imaging in 23 normal volunteers (G1) and 40 patients (G2) with HCM. Short axis images of the left ventricle were recorded at the base and the apex, and were divided into 5 segments, and % WT and % AR were measured for each segment. There were no significant differences in % WT and % AR among the segments in G1, while % WT of the posterior septum, posterior and lateral segments in the apex were higher than the according to end-diastolic wall thickness : G2a, ≦12mm ; G2b, 12＜≦15 ; G2c, ＞15. At each slice level, % WT and % AR were highest in G2a and lowest in G2c. These findings suggest that myocardial shortening in normal subjects is higher in the apex than in the base, and, in HCM, regional myocardial function decreases in association with an advance of hypertrophy, with a possible compensatory increased wall function of normal segments. en-copyright= kn-copyright= en-aut-name=SatoTetsuya en-aut-sei=Sato en-aut-mei=Tetsuya kn-aut-name=佐藤哲也 kn-aut-sei=佐藤 kn-aut-mei=哲也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部循環器内科学教室 en-keyword=cine MRI kn-keyword=cine MRI en-keyword=hypertrophic cardimyopathy kn-keyword=hypertrophic cardimyopathy en-keyword=regional myocardial function kn-keyword=regional myocardial function en-keyword=percrnt wall thickening kn-keyword=percrnt wall thickening en-keyword=percent change of segmental wall area kn-keyword=percent change of segmental wall area END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=127 end-page=134 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on anti-HTLV-Ⅰ antibody in interstitial lung diseases Part 2. Anti-HTLV-ⅠIgG, IgM, and IgA antibodies in HTLV-Ⅰ associated bronchiolo-alveolar disorder (HABA) kn-title=間質性肺疾患における抗 HTLV-Ⅰ抗体に関する研究　第2編 HTLV-Ⅰ関連細気管支･肺胞異常症 (HABA) における抗 HTLV-ⅠIgG, IgM, IgA 抗体に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To study the pathogenesis of HTLV-Ⅰassociated bronchiolo-alveolar disorder (HABA), Western blot analysis was performed using MT-2 cell lysate antigens on the serum of 6 patients with HABA, 7 patients with adult T cell leukamia (ATL), 14 asymptomatic carriers and 9 healthy controls. Five(83%) of the 6 HABA patients were positive for anti-HTLV-Ⅰ IgA antibodies, although all 7 ATL patients and 11 of the 14 asymptomatic carriers were negative. All HABA and ATL patients and asymptomatic carriers were positive for anti-HTLV-Ⅰ IgG antibodies. Four(67%) of the 6 HABA patients, 2(29%) of the 7 ATL patients and 9(64%) of the 14 asymptomatic carriers were positive for anti-HTLV-Ⅰ IgM antibodies. Statistically there was little difference in the incidences of anti-HTLV-Ⅰ IgG and IgM antibodies among HABA and ATL patients and asymptomatic carriers, but the HABA patients showed a significantly higher incedence of IgA antibody than the ATL patients and asymptomatic carriers. Since specific IgA antibodies are produced in the local infected mucosa and part of the IgA antibodies are transferred into the serum, in conclusion, the anti-HTLV-Ⅰ IgA antibodies in HABA patients reflect the localization of HTLV-Ⅰ in lungs which play an important role in the pathogenesis of HABA. en-copyright= kn-copyright= en-aut-name=UenoKatsumi en-aut-sei=Ueno en-aut-mei=Katsumi kn-aut-name=植野克巳 kn-aut-sei=植野 kn-aut-mei=克巳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=HTLV-Ⅰ関連細気管支・肺胞異常症 kn-keyword=HTLV-Ⅰ関連細気管支・肺胞異常症 en-keyword=抗 HTLV-ⅠIgA 抗体 kn-keyword=抗 HTLV-ⅠIgA 抗体 END