| JaLCDOI |
10.18926/AMO/46631
|
| フルテキストURL |
65_3_193.pdf
|
| 著者 |
Kawaura, Akihiko|
Tanida, Noritoshi|
Akiyama, Junichi|
Nonaka, Kouji|
Mizutani, Masatoshi|
Sawada, Kenji|
Nakagawa, Kimie|
Tsugawa, Naoko|
Izumi, Keisuke|
Ii, Kunio|
Okano, Toshio|
Takeda, Eiji|
|
| 抄録 |
Sixty-three male 5-week-old Syrian hamsters received the carcinogen N-nitrosobis(2-oxopropyl)amine (BOP) s.c. in 5 weekly injections (the first, 70mg/kg body, and the remaining, 20mg/kg each). The hamsters that received BOP were given intragastric administration of 0.2ml of medium chain triglyceride (MCT) with or without 0.04μg of 1α-hydroxyvitamin D3 [1α(OH)D3] through a feeding tube for 12 weeks. Thus, 3 groups were assigned:Group 1;BOP alone (n＝20), Group 2;BOP＋MCT (n＝18) and Group 3;BOP＋1α(OH)D3 (n＝25). The mean body weight of Group 3 was lower than those of Groups 1 and 2 at the end of the experiment (p＜0.001,Tukey-Kramer HSD test). At the end of week 12, all surviving hamsters were put to sleep. The incidences of liver tumors were 80%, 72% and 32% in Groups 1, 2 and 3, respectively. The incidence of tumors in Group 3 was significantly lower than in Group 1 and Group 2 (p＜0.05, χ2-test). All tumors were cholangiocarcinoma. These results indicated that BOP-induced cholangiocarcinogenesis was suppressed by the supplemental administration of 1α(OH)D3.
|
| キーワード |
1α-hydroxyvitamin D3
N-nitrosobis(2-oxopropyl)amine
cholangiocarcinogenesis
Syrian hamsters
|
| Amo Type |
Original Article
|
| 出版物タイトル |
Acta Medica Okayama
|
| 発行日 |
2011-06
|
| 巻 |
65巻
|
| 号 |
3号
|
| 出版者 |
Okayama University Medical School
|
| 開始ページ |
193
|
| 終了ページ |
197
|
| ISSN |
0386-300X
|
| NCID |
AA00508441
|
| 資料タイプ |
学術雑誌論文
|
| 言語 |
英語
|
| 著作権者 |
CopyrightⒸ 2011 by Okayama University Medical School
|
| 論文のバージョン |
publisher
|
| 査読 |
有り
|
| PubMed ID |
21709717
|
| Web of Science KeyUT |
000292017500006
|
