検索結果 - 岡山大学学術成果リポジトリ

Histone Demethylase Jmjd3 Regulates the Osteogenic Differentiation and Cytokine Expressions of Periodontal Ligament Cells

JaLCDOI	10.18926/AMO/63722
フルテキストURL	76_3_281.pdf
著者	Yu, Bo\| Wang, Rui\| Luo, Huikun\| Yang, Di\| Wang, Simo\| Yu, Yaqiong\| Okamura, Hirohiko\| Qiu, Lihong\|
抄録	Periodontal ligament (PDL) cells are critical for the bone remodeling process in periapical lesions since they can differentiate into osteoblasts and secrete osteoclastogenesis-promoting cytokines. Post-translational histone modifications including alterations of the methylation status of H3K27 are involved in cell differentiation and inflammatory reaction. The histone demethylase Jumonji domain-containing 3 (Jmjd3) specifically removes methylation of H3K27. We investigated whether Jmjd3 is involved in the osteogenic differentiation and secretion of PDL cells’ inflammatory factors. Jmjd3 expression in periapical lesions was examined by immunostaining. Using siRNA specific for Jmjd3 or the specific Jmjd3 inhibitor GSK-J4, we determined Jmjd3’s roles in osteogenic differentiation and cytokine production by real-time RT-PCR. The locations of Jmjd3 and NF-κB were analyzed by immunocytochemistry. Compared to healthy PDLs, the periapical lesion samples showed higher Jmjd3 expression. Treatment with GSK-J4 or Jmjd3 siRNA suppressed PDL cells’ osteogenic differentiation by suppressing the expressions of bone-related genes (Runx2, Osterix, and osteocalcin) and mineralization. Jmjd3 knockdown decreased the expressions of cytokines (TNF-α, IL-1β, and IL-6) induced by lipopolysaccharide extracted from Porphyromonas endodontalis (Pe-LPS). Pe-LPS induced the nuclear translocations of Jmjd3 and NF-κB; the latter was inhibited by GSK-J4 treatment. Jmjd3 appears to regulate PDL cells’ osteogenic differentiation and proinflammatory cytokine expressions.
キーワード	periapical lesions histone demethylase Jmjd3 periodontal ligament cell osteogenic differentiation proinflammatory cytokines
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-06
巻	76巻
号	3号
出版者	Okayama University Medical School
開始ページ	281
終了ページ	290
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35790358
Web of Science KeyUT	000823568300007

Intrathecal Administration of the α1 Adrenergic Antagonist Phentolamine Upregulates Spinal GLT-1 and Improves Mirror Image Pain in SNI Model Rats

JaLCDOI	10.18926/AMO/63719
フルテキストURL	76_3_255.pdf
著者	Nakatsuka, Kosuke\| Matsuoka, Yoshikazu\| Kurita, Masako\| Wang, Ruilin\| Tsuboi, Chika\| Sue, Nobutaka\| Kaku, Ryuji\| Morimatsu, Hiroshi\|
抄録	Mirror image pain (MIP) is a type of extraterritorial pain that results in contralateral pain or allodynia. Glutamate transporter-1 (GLT-1) is expressed in astrocytes and plays a role in maintaining low glutamate levels in the synaptic cleft. Previous studies have shown that GLT-1 dysfunction induces neuropathic pain. Our previous study revealed bilateral GLT-1 downregulation in the spinal cord of a spared nerve injury (SNI) rat. We hypothesized that spinal GLT-1 is involved in the mechanism of MIP. We also previously demonstrated noradrenergic GLT-1 regulation. Therefore, this study aimed to investigate the effect of an α1 adrenergic antagonist on the development of MIP. Rats were subjected to SNI. Changes in pain behavior and GLT-1 protein levels in the SNI rat spinal cords were then examined by intrathecal administration of the α1 adrenergic antagonist phentolamine, followed by von Frey test and western blotting. SNI resulted in the development of MIP and bilateral downregulation of GLT-1 protein in the rat spinal cord. Intrathecal phentolamine increased contralateral GLT-1 protein levels and partially ameliorated the 50% paw withdrawal threshold in the contralateral hind paw. Spinal GLT-1 upregulation by intrathecal phentolamine ameliorates MIP. GLT-1 plays a role in the development of MIPs.
キーワード	alpha adrenergic receptor glutamate transporter-1 mirror image pain neuropathic pain spared nerve injury
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-06
巻	76巻
号	3号
出版者	Okayama University Medical School
開始ページ	255
終了ページ	263
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35790355
Web of Science KeyUT	000823568300004

Endoscopic features of oxyntic gland adenoma and gastric adenocarcinoma of the fundic gland type differ between patients with and without Helicobacter pylori infection: a retrospective observational study

フルテキストURL	fulltext.pdf
著者	Iwamuro, Masaya\| Kusumoto, Chiaki\| Nakagawa, Masahiro\| Matsueda, Kazuhiro\| Kobayashi, Sayo\| Yoshioka, Masao\| Inaba, Tomoki\| Toyokawa, Tatsuya\| Sakaguchi, Chihiro\| Tanaka, Shouichi\| Tanaka, Takehiro\| Okada, Hiroyuki\|
キーワード	Gastric neoplasms Oxyntic gland adenoma Gastric adenocarcinoma of the fundic gland type
発行日	2022-06-12
出版物タイトル	BMC Gastroenterology
巻	22巻
号	1号
出版者	BMC
開始ページ	294
ISSN	1471-230X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022.
論文のバージョン	publisher
PubMed ID	35692036
DOI	10.1186/s12876-022-02368-w
Web of Science KeyUT	000809663500001
関連URL	isVersionOf https://doi.org/10.1186/s12876-022-02368-w

インターフェロンbが骨芽細胞分化に及ぼす影響

フルテキストURL	K0006606_abstract_review.pdf K0006606_fulltext.pdf K0006606_summary.pdf
著者	田中敦子\|
発行日	2022-03-25
資料タイプ	学位論文
学位授与番号	甲第6606号
学位授与年月日	2022-03-25
学位・専攻分野	博士（歯学）
授与大学	岡山大学
言語	日本語

Suppression of Bone Necrosis around Tooth Extraction Socket in a MRONJ-like Mouse Model by E-rhBMP-2 Containing Artificial Bone Graft Administration

フルテキストURL	K0006602_abstract_review.pdf K0006602_fulltext.pdf K0006602_summary.pdf
著者	田仲由希恵\|
発行日	2022-03-25
資料タイプ	学位論文
学位授与番号	甲第6602号
学位授与年月日	2022-03-25
学位・専攻分野	博士（歯学）
授与大学	岡山大学
言語	英語
著作権者	© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

CT evaluation of patent artery after percutaneous cryoablation of renal cell carcinoma

フルテキストURL	K0006597_abstract_review.pdf K0006597_fulltext.pdf K0006597_summary.pdf
著者	梶田聡一郎\|
発行日	2022-03-25
資料タイプ	学位論文
学位授与番号	甲第6597号
学位授与年月日	2022-03-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語
著作権者	© 2021 Société française de radiologie. Published by Elsevier Masson SAS.

Propofol sedation with a target-controlled infusion pump in elderly patients undergoing ERCP

フルテキストURL	K0006595_abstract_review.pdf K0006595_fulltext.pdf K0006595_summary.pdf
著者	小川泰司\|
発行日	2022-03-25
資料タイプ	学位論文
学位授与番号	甲第6595号
学位授与年月日	2022-03-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語
著作権者	© 2020 by the American Society for Gastrointestinal Endoscopy

Microsatellite instability analysis and its prognostic value in invasive nonampullary duodenal adenocarcinoma

フルテキストURL	K0006583_abstract_review.pdf K0006583_fulltext.pdf K0006583_summary.pdf
著者	楊光\|
発行日	2022-03-25
資料タイプ	学位論文
学位授与番号	甲第6583号
学位授与年月日	2022-03-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語
著作権者	© 2022 S. Karger AG, Basel

The efficacy of pancreatic juice cytology with liquid-based cytology for evaluating malignancy in patients with intraductal papillary mucinous neoplasm

フルテキストURL	K0006540_abstract_review.pdf K0006540_fulltext.pdf K0006540_summary.pdf
著者	宮本和也\|
発行日	2022-03-25
資料タイプ	学位論文
学位授与番号	甲第6540号
学位授与年月日	2022-03-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語
著作権者	© The Author(s). 2020

Long-Term Results of Posterior Vertebral Column Resection for Severe Thoracolumbar Kyphosis with Achondroplastic Patients: A Case Series

フルテキストURL	fulltext.pdf
著者	Tanaka, Masato\| Chan, Tsang-Tung\| Misawa, Haruo\| Uotani, Koji\| Arataki, Shinaya\| Takigawa, Tomoyuki\| Mazaki, Tetsuro\| Sugimoto, Yoshihisa\|
キーワード	achondroplasia vertebral column osteotomy long-term follow-up navigation
発行日	2022-04-27
出版物タイトル	Medicina
巻	58巻
号	5号
出版者	MDPI
開始ページ	605
ISSN	1010-660X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
PubMed ID	35630021
DOI	10.3390/medicina58050605
Web of Science KeyUT	000802445600001
関連URL	isVersionOf https://doi.org/10.3390/medicina58050605

Lattice Boltzmann model for capillary interactions between particles at a liquid-vapor interface under gravity

フルテキストURL	fulltext20220602-4.pdf
著者	Mino, Yasushi\| Tanaka, Hazuki\| Nakaso, Koichi\| Gotoh, Kuniaki\| Shinto, Hiroyuki\|
発行日	2022-4-25
出版物タイトル	Physical Review E
巻	105巻
号	4号
出版者	American Physical Society (APS)
開始ページ	045316
ISSN	2470-0045
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	©2022 American Physical Society
論文のバージョン	author
PubMed ID	35590684
DOI	10.1103/physreve.105.045316
Web of Science KeyUT	000796375200002
関連URL	isVersionOf https://doi.org/10.1103/physreve.105.045316

岡山市北部吉備高原地域に分布する古第三系・新第三系の分布・堆積相と古地理変遷

JaLCDOI	10.18926/ESR/63514
タイトル（別表記）	Depositional history of the Paleogene to Neogene valley fill deposits and topographic change in the Kibi Plateau region, Okayama City, Southwest Japan
フルテキストURL	esr_028_001_025.pdf
著者	田中元\| 鈴木茂之\|
キーワード	Kibi Plateau Surface Paleogene Kibi Group Miocene Bihoku Group
出版物タイトル	Okayama University Earth Science Report
発行日	2022-03-31
巻	28巻
号	1号
開始ページ	1
終了ページ	25
ISSN	1340-7414
言語	日本語
著作権者	© 2022 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved
論文のバージョン	publisher

One-step nucleic acid amplification for intraoperative diagnosis of lymph node metastasis in lung cancer patients: a single-center prospective study

フルテキストURL	fulltext.pdf
著者	Namba, Kei\| Suzawa, Ken\| Shien, Kazuhiko\| Miura, Akihiro\| Takahashi, Yuta\| Miyauchi, Shunsaku\| Araki, Kota\| Nakata, Kentaro\| Tomida, Shuta\| Tanaka, Shin\| Miyoshi, Kentaroh\| Otani, Shinji\| Yamamoto, Hiromasa\| Okazaki, Mikio\| Sugimoto, Seiichiro\| Soh, Junichi\| Yamane, Masaomi\| Toyooka, Shinichi\|
発行日	2022-05-04
出版物タイトル	Scientific Reports
巻	12巻
号	1号
出版者	Nature Portfolio
開始ページ	7297
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022
論文のバージョン	publisher
PubMed ID	35508484
DOI	10.1038/s41598-022-11064-4
Web of Science KeyUT	000790941900040
関連URL	isVersionOf https://doi.org/10.1038/s41598-022-11064-4

Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples

フルテキストURL	fulltext20220518-2.pdf
著者	Oshimi, Keisuke\| Nishimura, Yushi\| Matsubara, Tsutomu\| Tanaka, Masuaki\| Shikoh, Eiji\| Zhao, Li\| Zou, Yajuan\| Komatsu, Naoki\| Ikado, Yuta\| Takezawa, Yuka\| Kage-Nakadai, Eriko\| Izutsu, Yumi\| Yoshizato, Katsutoshi\| Morita, Saho\| Tokunaga, Masato\| Yukawa, Hiroshi\| Baba, Yoshinobu\| Teki, Yoshio\| Fujiwara, Masazumi\|
備考	This is an accepted manuscript published by The Royal Society of Chemistry. This fulltext is available in May 2023.\|
発行日	2022-05-01
出版物タイトル	Lab on a Chip
巻	22巻
号	13号
出版者	Royal Society of Chemistry (RSC)
開始ページ	2519
終了ページ	2530
ISSN	1473-0197
NCID	AA11596906
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Royal Society of Chemistry 2022
論文のバージョン	author
PubMed ID	35510631
DOI	10.1039/d2lc00112h
Web of Science KeyUT	000790843700001
関連URL	isVersionOf https://doi.org/10.1039/d2lc00112h

Clinicopathological Characteristics of Superficial Barrett's Adenocarcinoma in a Japanese Population: A Retrospective, Multicenter Study

フルテキストURL	fulltext.pdf
著者	Hamada, Kenta\| Kanzaki, Hiromitsu\| Miyahara, Koji\| Nakagawa, Masahiro\| Mouri, Hirokazu\| Mizuno, Motowo\| Takahashi, Sakuma\| Hori, Shinichiro\| Nasu, Junichiro\| Tsuzuki, Takao\| Miyaike, Jiro\| Takenaka, Ryuta\| Yamauchi, Kenji\| Kobayashi, Sayo\| Toyokawa, Tatsuya\| Inoue, Masafumi\| Nishimura, Mamoru\| Matsubara, Minoru\| Tomoda, Jun\| Yamasaki, Yasushi\| Tanaka, Takehiro\| Shirakawa, Yasuhiro\| Kawahara, Yoshiro\| Fujiwara, Toshiyoshi\| Okada, Hiroyuki\| Okayama Gut Study Group\|
キーワード	Barrett's adenocarcinoma endoscopic resection long -segment Barrett's esophagus metachronous lesion short -segment Barrett's esophagus surgery
発行日	2022-04-15
出版物タイトル	INTERNAL MEDICINE
巻	61巻
号	8号
出版者	The Japanese Society of Internal Medicine
開始ページ	1115
終了ページ	1123
ISSN	0918-2918
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Japanese Society of Internal Medicine
論文のバージョン	publisher
PubMed ID	35431302
DOI	10.2169/internalmedicine.6942-20
Web of Science KeyUT	000789463700001
関連URL	isVersionOf https://doi.org/10.2169/internalmedicine.6942-20

Overexpression of Adenovirus E1A Reverses Transforming Growth Factor-β-induced Epithelial-mesenchymal Transition in Human Esophageal Cancer Cells

JaLCDOI	10.18926/AMO/63425
フルテキストURL	76_2_203.pdf
著者	Masuda, Tomoya\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Ieda, Takeshi\| Kikuchi, Satoru\| Kuroda, Shinji\| Noma, Kazuhiro\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
抄録	The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer. However, therapeutic strategies to inhibit EMT in tumor environments remain elusive. Here, we show the therapeutic potential of telomerase-specific replication- competent oncolytic adenovirus OBP-301 in human esophageal cancer TE4 and TE6 cells with an EMT phenotype. Transforming growth factor-β (TGF-β) administration induced the EMT phenotype with spindleshaped morphology, upregulation of mesenchymal markers and EMT transcription factors, migration, and chemoresistance in TE4 and TE6 cells. OBP-301 significantly inhibited the EMT phenotype via E1 accumulation. EMT cancer cells were susceptible to OBP-301 via massive autophagy induction. OBP-301 suppressed tumor growth and lymph node metastasis of TE4 cells co-inoculated with TGF-β-secreting fibroblasts. Our results suggest that OBP-301 inhibits the TGF-β-induced EMT phenotype in human esophageal cancer cells. OBP-301-mediated E1A overexpression is a promising antitumor strategy to inhibit EMT-mediated esophageal cancer progression.
キーワード	esophageal cancer EMT TGF-β oncolytic adenovirus E1A
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-04
巻	76巻
号	2号
出版者	Okayama University Medical School
開始ページ	203
終了ページ	215
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35503449
Web of Science KeyUT	000792291900003

Survival and prognostic factors in patients undergoing pulmonary metastasectomy for lung metastases from retroperitoneal sarcoma

フルテキストURL	fulltext.pdf
著者	Takatsu, Fumiaki\| Yamamoto, Hiromasa\| Tomioka, Yasuaki\| Tanaka, Shin\| Shien, Kazuhiko\| Suzawa, Ken\| Miyoshi, Kentaroh\| Otani, Shinji\| Okazaki, Mikio\| Sugimoto, Seiichiro\| Yamane, Masaomi\| Takahashi, Katsuhito\| Toyooka, Shinichi\|
キーワード	Retroperitoneal sarcoma Lung metastasis Metastasectomy
発行日	2022-04-08
出版物タイトル	World Journal Of Surgical Oncology
巻	20巻
号	1号
出版者	BMC
開始ページ	114
ISSN	1477-7819
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022.
論文のバージョン	publisher
PubMed ID	35395855
DOI	10.1186/s12957-022-02552-y
Web of Science KeyUT	000780301100001
関連URL	isVersionOf https://doi.org/10.1186/s12957-022-02552-y

Survey of Shoulder Osteoarthritis in Patients who Underwent Total Hip Arthroplasty for Hip Osteoarthritis

JaLCDOI	10.18926/AMO/63411
フルテキストURL	76_2_173.pdf
著者	Miyake, Yoshiaki\| Mitani, Shigeru\| Namba, Yoshifumi\| Umehara, Norifumi\| Kawamoto, Toyohiro\| Furuichi, Shuro\|
抄録	To the best of our knowledge, no previous studies have reported a relationship between osteoarthritis (OA) of the lower limbs and OA of the shoulder joints. We evaluated the correlation between shoulder OA and hip OA. We collected contrast-enhanced computed tomography (CECT) images of the shoulder joints of 159 patients with hip OA who underwent primary total hip arthroplasty (THA). The images, taken 1 week after THA to monitor venous thromboembolism (VTE), were used to examine the prevalence of shoulder OA. They were compared with those of 103 controls who underwent CECT during the same period to monitor VTE. Shoulder OA was observed in 15% of the controls and 24% of the THA patients. Although the rate was somewhat higher in the THA group, the difference was not significant. However, in the THA group, significantly more patients with bilateral hip OA (33%) had shoulder OA than those with unilateral hip OA (17%). In summary, the prevalence of shoulder OA was significantly higher in patients with bilateral hip OA. In these patients, pain and instability in the hip joints require them to use arm support to stand up or walk, putting the weight-bearing shoulder at risk of developing OA.
キーワード	shoulder osteoarthritis hip osteoarthritis weight-bearing shoulder total hip arthroplasty
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-04
巻	76巻
号	2号
出版者	Okayama University Medical School
開始ページ	173
終了ページ	177
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35503445
Web of Science KeyUT	000792374900009

Clinicopathological Features and Surgical Outcomes of Small Bowel Metastasis from Renal Cell Carcinoma

JaLCDOI	10.18926/AMO/63409
フルテキストURL	76_2_155.pdf
著者	Kimura, Jiro\| Okabayashi, Takehiro\| Sui, Kenta\| Tabuchi, Motoyasu\| Iwata, Jun\| Hata, Yasuhiro\| Iiyama, Tatsuo\| Ono, Noriaki\|
抄録	Small bowel metastasis from renal cell carcinoma (RCC) is rare, and its clinicopathological characteristics are unclear; thus, we revisited the concept of this tumor and reviewed its diagnostic and treatment modalities. We filtered MEDLINE searches of articles published in English between 1950 and 2019, and identified 100 patients who had undergone treatment, including 1 patient from our clinic. We extracted patient characteristics, treatment, and prognostic data, resulting in clinicopathological data on 100 patients (83 men, 17 women). Mean age was 63 years (range, 16-86 years). Tumor sites were duodenum, jejunum, ileum, and multiple sites in 30, 37, 25, and 7 patients, respectively. The 1-, 3-, and 5-year overall survival rates after diagnosis were 53.0%, 36.0%, and 36.0%. Curative resection patients showed 62.1% 5-year survival after surgery, vs. 27.5% in noncurative surgical management cases. Good prognoses can be expected if these tumors are identified early for complete removal. Surgery is the only curative option. To determine the best management strategy and improve prognostic accuracy, we continue to collect and analyze epidemiological and pathological data. Although this condition is rare, surgery should be considered if curative resection is expected. Prognosis after curative resection is not poor, but recurrence is not unlikely.
キーワード	renal cell carcinoma small bowel metastasis intestine tumor
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-04
巻	76巻
号	2号
出版者	Okayama University Medical School
開始ページ	155
終了ページ	165
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35503443
Web of Science KeyUT	000792374900007

Grade of Subchondral Insufficiency Fracture of the Knee and the Presence of a Posterior Shiny-Corner Lesion are Correlated with Duration of Medial Meniscus Posterior Root Tear in Women

JaLCDOI	10.18926/AMO/63405
フルテキストURL	76_2_121.pdf
著者	Okazaki, Yuki\| Furumatsu, Takayuki\| Hiranaka, Takaaki\| Kamatsuki, Yusuke\| Nakata, Eiji\| Tetsunaga, Tomonori\| Yamane, Kentaro\| Ozaki, Toshifumi\|
抄録	Bone marrow edema (BME) after meniscus injury and risk factors for subchondral insufficiency fracture of the knee (SIFK) have been reported. However, their association with medial meniscus posterior root tear (MMPRT) remains unknown. We investigated the association of BME volume (BME-V), posterior shinycorner lesion (PSCL), and SIFK with MMPRT to examine the correlations between BME-V and medial meniscus extrusion (MME), PSCL and duration from injury to the time of magnetic resonance imaging (duration), and SIFK and duration. Twenty-nine patients who underwent surgery for MMPRT were included (mean age, 59.2; range, 39-84). The presence of PSCL, femoral BME-V (cm3), and SIFK grade (1-4) were evaluated. Preoperative factors, such as MME (mm) and duration (weeks), were investigated using multivariate linear/ logistic regression analyses. Multivariate linear regression analysis revealed duration as a significant factor for high-grade SIFK (p<0.01). Multivariate logistic regression analysis revealed duration as a significant factor for the presence of PSCL (odds ratio=0.94, p<0.05). A long duration of MMPRT leads to severe MME and highgrade SIFK (3 and 4), often resulting in knee arthroplasty. Early diagnosis of MMPRT and pullout repair can prevent severe MME and high-grade SIFK.
キーワード	medial meniscus posterior root tear subchondral insufficiency fracture bone marrow edema meniscus extrusion
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-04
巻	76巻
号	2号
出版者	Okayama University Medical School
開始ページ	121
終了ページ	127
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35503439
Web of Science KeyUT	000792374900003