検索結果 1692 件
| JaLCDOI | 10.18926/AMO/57951 |
|---|---|
| フルテキストURL | 74_1_41.pdf |
| 著者 | Amano, Hoichi| Fujimoto, Kenichi| Fujimori, Makoto| Saka, Natsumi| Nomura, Kyoko| Tanihara, Shinichi| |
| 抄録 | We aimed to clarify the prevalence of polypharmacy among elderly individuals in Japan. We used the data obtained from a large-scale population-based representative database of health insurance claims in a single prefecture in Japan. We examined all of the outpatient and pharmaceutical health insurance claims for National Health Insurance and those for Late-stage Elderly Health Insurance in Nagasaki Prefecture, Japan between April and June 2016. When two or more claim forms were issued for a patient in a single month, we combined the data and identified the number of prescribed drugs for each person. The definition of polypharmacy is a the prescription of six or more drugs per month. We investigated the prevalence of polypharmacy among the beneficiaries of the two insurance systems. Of the 605,406 beneficiaries of the 2 insurance systems, 121,033 (20.0%) patients with polypharmacy were identified. The prevalence of polypharmacy increased with age, especially among the beneficiaries aged > 85 years, with about half of the beneficiaries having polypharmacy status. About half of the people aged > 85 years in the database had polypharmacy status. When a drug is prescribed to an elderly individual, it is necessary to consider the possibility of polypharmacy-related problems. |
| キーワード | health insurance claims late-stage elderly health insurance national health insurance Japan polypharmacy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-02 |
| 巻 | 74巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 41 |
| 終了ページ | 48 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32099247 |
| Web of Science KeyUT | 000516606200006 |
| NAID | 120006795618 |
| JaLCDOI | 10.18926/AMO/57950 |
|---|---|
| フルテキストURL | 74_1_33.pdf |
| 著者 | Honda, Hiroyuki| Hanayama, Yoshihisa| Obika, Mikako| Hasegawa, Kou| Hamahara, Jun| Kishida, Masayuki| Hagiya, Hideharu| Ogawa, Hiroko| Kataoka, Hitomi| Otsuka, Fumio| |
| 抄録 | A relationship between diabetes and depression is apparent. To clarify the clinical relevance of diabetic patients’ gastroesophageal symptoms to their psychological status, we retrospectively analyzed the data from a Selfrating Depression Scale (SDS) and a Frequency Scale for Symptoms of Gastroesophageal reflux disease (FSSG) among 143 type 2 diabetic patients who visited a general medicine department. Among the 45 Japanese patients enrolled, the group with relatively high SDS scores (≥ 36) showed higher (FSSG) dysmotility symptom scores versus the low-SDS (< 36) group, although the 2 groups’ characteristics and laboratory data were not significantly different. Positive correlations of postprandial plasma glucose (PPG) levels with FSSG scores (R=0.321, p<0.05), particularly with reflux scores (R=0.455, p<0.01) were revealed. PPG and HbA1c levels were not correlated with SDS scores. The patients’ SDS scores were significantly correlated with their FSSG scores (R=0.41, p<0.01), suggesting that depressive status is linked to GERD-related manifestations. Considering that the patients’ PPG levels were correlated with GERD-related symptoms, diabetic patients’ blood glucose levels are associated with depressive status. Collectively, key symptoms related to GERD and glucose level values would be helpful |
| キーワード | blood glucose type 2 diabetes mellitus gastroesophageal reflux depressive status postprandial plasma glucose |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-02 |
| 巻 | 74巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 33 |
| 終了ページ | 40 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32099246 |
| Web of Science KeyUT | 000516606200005 |
| NAID | 120006795617 |
| 著者 | Tanaka, Takashi| Huang, Yong| Marukawa, Yohei| Tsuboi, Yuka| Masaoka, Yoshihisa| Kojima, Katsuhide| Iguchi, Toshihiro| Hiraki, Takao| Gobara, Hideo| Yanai, Hiroyuki| Nasu, Yasutomo| Kanazawa, Susumu| |
|---|---|
| キーワード | MDCT artificial intelligence kidney neoplasms neural network models |
| 発行日 | 2020-01-08 |
| 出版物タイトル | American journal of roentgenology |
| 出版者 | American Roentgen Ray Society |
| 開始ページ | 1 |
| 終了ページ | 8 |
| ISSN | 0361-803X |
| NCID | AA00521224 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 31913072 |
| DOI | 10.2214/AJR.19.22074 |
| 関連URL | isVersionOf https://doi.org/10.2214/AJR.19.22074 |
| フルテキストURL | MIB21_3_519.pdf |
|---|---|
| 著者 | Matsuura, Yuki| Ueda, Masashi| Higaki, Yusuke| Sano, Kohei| Saji, Hideo| Enomoto, Shuichi| |
| キーワード | Alzheimer's disease Nicotinic acetylcholine receptors 2-Deoxy-2-[F-18]fluoro-D-glucose ([F-18]FDG) 5-[I-123]Iodo-3-[2(S)-azetidinylmethoxy]pyridine ([I-123]5IA) APP PS2 mice |
| 発行日 | 2018-07-25 |
| 出版物タイトル | Molecular Imaging and Biology |
| 巻 | 21巻 |
| 号 | 3号 |
| 出版者 | Springer |
| 開始ページ | 519 |
| 終了ページ | 528 |
| ISSN | 1536-1632 |
| NCID | AA1170000X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 30047036 |
| DOI | 10.1007/s11307-018-1253-4 |
| Web of Science KeyUT | 000468363800015 |
| 関連URL | isVersionOf https://doi.org/10.1007/s11307-018-1253-4 |
| フルテキストURL | AOTS20191023.pdf fig.pdf Table.pdf |
|---|---|
| 著者 | Yamamoto, Norio| Noda, Tomoyuki| Saito, Taichi| Uehara, Takenori| Shimamura, Yasunori| Ozaki, Toshifumi| |
| キーワード | Acetabular fracture External iliac artery External iliac vein Ilioinguinal approach Occlusion Thrombosis |
| 備考 | This is a post-peer-review, pre-copyedit version of an article published in Archives of Orthopaedic and Trauma Surgery. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00402-019-03288-3.| |
| 発行日 | 2019-10-23 |
| 出版物タイトル | Archives of Orthopaedic and Trauma Surgery |
| 巻 | 140巻 |
| 号 | 4号 |
| 出版者 | Springer |
| 開始ページ | 481 |
| 終了ページ | 485 |
| ISSN | 0936-8051 |
| NCID | AA10738765 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 31642955 |
| DOI | 10.1007/s00402-019-03288-3 |
| Web of Science KeyUT | 000492001100001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s00402-019-03288-3 |
| フルテキストURL | JAD68_4_1667.pdf Fig.pdf |
|---|---|
| 著者 | Shi, Xiaowen | Liu, Xia| Shang, Jingwei| Morihara, Ryuta| Nakano, Yumiko| Feng, Tian| Huang, Yong| Sato, Kota| Takemoto, Mami| Hishikawa, Nozomi| 山下 徹| Abe, Koji| |
| キーワード | AHSG APP23 mice ITIH4 alzheimer’s disease hypoperfusion inflammation |
| 発行日 | 2019-04-23 |
| 出版物タイトル | Journal of Alzheimer's Disease |
| 巻 | 68巻 |
| 号 | 4号 |
| 出版者 | IOS Press |
| 開始ページ | 1667 |
| 終了ページ | 1675 |
| ISSN | 1387-2877 |
| NCID | AA11545428 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 30958362 |
| DOI | 10.3233/JAD-181218 |
| Web of Science KeyUT | 000465612500029 |
| 関連URL | isVersionOf https://doi.org/10.3233/JAD-181218 |
| JaLCDOI | 10.18926/AMO/57722 |
|---|---|
| フルテキストURL | 73_6_547.pdf |
| 著者 | Yokoyama, Akihiro| Kada, Akiko| Saito, Akiko M.| Sawamura, Morio| Komeno, Takuya| Sunami, Kazutaka| Takezako, Naoki| |
| 抄録 | Elderly multiple myeloma (MM) patients, who are generally ineligible for transplantation, have high risks of death and treatment discontinuation, and require a regimen incorporating novel agents that balance safety, tolerability, and efficacy. We evaluated alternating bortezomib-dexamethasone and lenalidomide-dexamethasone treatments administered over a 63-day cycle in transplant-ineligible elderly patients with newly diagnosed MM. Subcutaneous bortezomib 1.3 mg/m2 was administered weekly on Days 1, 8, 15, and 22; oral lenalidomide 15 mg daily on Days 36-56; and oral dexamethasone 20 mg on Days 1, 8, 15, 22, 36, 43, 50, and 57 for 6 cycles. The primary endpoint was the overall response rate. |
| キーワード | bortezomib lenalidomide dexamethasone myeloma |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-12 |
| 巻 | 73巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 547 |
| 終了ページ | 552 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31871340 |
| Web of Science KeyUT | 000503431400013 |
| JaLCDOI | 10.18926/AMO/57720 |
|---|---|
| フルテキストURL | 73_6_537.pdf |
| 著者 | Takahara, Yasuhiro| Nishida, Keiichiro| Nakashima, Hirotaka| Ochi, Nobuaki| Uchida, Yoichiro| Kato, Hisayoshi| Itani, Satoru| Nakamura, Makoto| Iwasaki, Yuichi| Tsujimura, Yoshitaka| |
| 抄録 | High tibial osteotomy (HTO) procedure is generally contraindicated in rheumatoid arthritis (RA) patients because synovial inflammation may exacerbate joint damage post-surgery. The natural course of joint destruction in RA changed dramatically with new treatment strategies and the introduction of biologic disease-modifying anti-rheumatic drugs (bDMARDs). We report the cases of two RA patients who underwent HTO and whose disease activities were well controlled by bDMARDs. Despite their short follow-up periods, they showed acceptable objective and subjective clinical results. We believe that the combination of bDMARDs and HTO can be indicated for selected RA patients before total knee arthroplasty. |
| キーワード | high tibial osteotomy rheumatoid arthritis biologic DMARD knee surgery |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-12 |
| 巻 | 73巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 537 |
| 終了ページ | 542 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31871338 |
| Web of Science KeyUT | 000503431400011 |
| JaLCDOI | 10.18926/AMO/57715 |
|---|---|
| フルテキストURL | 73_6_511.pdf |
| 著者 | Takahara, Yasuhiro| Furumatsu, Takayuki| Nakashima, Hirotaka| Itani, Satoru| Nakamura, Makoto| Uchida, Yoichiro| Kato, Hisayoshi| Tsujimura, Yoshitaka| Iwasaki, Yuichi| Ochi, Nobuaki| |
| 抄録 | Medial open- and lateral closed-wedge high tibial osteotomy (hybrid CWHTO) can overcome the limitations of conventional CWHTO and open-wedge HTO (OWHTO) for medial compartmental osteoarthritis (OA) of the knee. Hybrid CWHTO increases stability by using a rigid locking plate and allows early full weight-bearing. However, the literature contains no information about time to bone union after this new procedure. The aim of this study is to evaluate the time to bone union after hybrid CWHTO. We reviewed 44 knees treated with hybrid CWHTO. Patients were able to stand on both legs on the day after surgery and walked with full weight-bearing within 4 weeks of the procedure. The time to achievement of bone union at the osteotomy site was defined as the number of months until bone union was confirmed on radiographic imaging. The mean time to radiographic confirmation of bone union was 4.5±1.5 months after surgery. Eleven knees (25.0%) required 6 months or more. Radiographic analysis and JOA score improved significantly between before and 1 year after surgery (p<0.01). Hybrid CWHTO is a very useful method for treating medial OA, but radiographic bone union requires 4.5 months on average. We must be aware of bone union after hybrid CWHTO. |
| キーワード | bone union hybrid closed-wedge high tibial osteotomy osteoarthritis |
| Amo Type | Original Article |
| 備考 | ,| |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-12 |
| 巻 | 73巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 511 |
| 終了ページ | 516 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31871333 |
| Web of Science KeyUT | 000503431400006 |
| JaLCDOI | 10.18926/AMO/57710 |
|---|---|
| フルテキストURL | 73_6_475.pdf |
| 著者 | Umebayashi, Ryoko| Uchida, Haruhito A.| Wada, Junzo| |
| 抄録 | Abdominal aortic aneurysms (AAAs) usually expand asymptomatically until the occurrence of a life-threatening event such as aortic rupture, which is closely associated with high mortality. AAA and aortic dissection are ranked among the top 10 causes of death in Japan. The major risk factors for AAA are age over 65 years, male gender, family history, and smoking. Thus, for prevention, smoking cessation is the most important lifestyle-intervention. For treatment, since AAA generally affects elderly people, less invasive treatment is preferable. However, the only established treatment for AAA is open repair and endovascular repair. This review describes potential medical treatments to slow aneurysm growth or prevent AAA rupture. |
| キーワード | abdominal aortic aneurysms medical treatment anti-platelet drugs |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-12 |
| 巻 | 73巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 475 |
| 終了ページ | 477 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31871328 |
| Web of Science KeyUT | 000503431400001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ohue, Yoshihiro| Kurose, Koji| Karasaki, Takahiro| Isobe, Midori| Yamaoka, Takaaki| Futami, Junichiro| Irei, Isao| Masuda, Takeshi| Fukuda, Masaaki| Kinoshita, Akitoshi| Matsushita, Hirokazu| Shimizu, Katsuhiko| Nakata, Masao| Hattori, Noboru| Yamaguchi, Hiroyuki| Fukuda, Minoru| Nozawa, Ryohei| Kakimi, Kazuhiro| Oka, Mikio| |
| キーワード | Biomarker Anti-programmed death 1 therapy NSCLC Cancer-testis antigen Serum antibody |
| 発行日 | 2019-12-31 |
| 出版物タイトル | Journal of Thoracic Oncology |
| 巻 | 14巻 |
| 号 | 12号 |
| 出版者 | Elsevier |
| 開始ページ | 2071 |
| 終了ページ | 2083 |
| ISSN | 15560864 |
| NCID | AA12058455 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. |
| 論文のバージョン | publisher |
| PubMed ID | 31449889 |
| DOI | 10.1016/j.jtho.2019.08.008 |
| Web of Science KeyUT | 000497971700018 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jtho.2019.08.008 |
| JaLCDOI | 10.18926/AMO/57379 |
|---|---|
| フルテキストURL | 73_5_469.pdf |
| 著者 | Yamasaki, Satoshi| Kada, Akiko| Nagai, Hirokazu| Yoshida, Isao| Choi, Ilseung| Saito, Akiko M.| Iwasakia, Hiromi| |
| 抄録 | Romidepsin is an important therapeutic option for patients with peripheral T-cell lymphoma (PTCL). However, the timing of romidepsin administration remains controversial. Romidepsin was launched in Japan as a consolidation therapy agent after conventional salvage chemotherapy with gemcitabine, dexamethasone, and cisplatin (GDP). GDP therapy will be administered every 3 weeks. If complete response, partial response, or stable disease is confirmed after 2-4 GDP cycles, romidepsin will be administered every 4 weeks. The primary endpoint is a 2-year progression-free survival rate. Patients participating in this study and undergoing treatment can expect results similar to or better than those of conventional therapies. |
| キーワード | peripheral T-cell lymphoma not otherwise specified angioimmunoblastic T-cell lymphoma gemcitabine cisplatin, romidepsin |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-10 |
| 巻 | 73巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 469 |
| 終了ページ | 474 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31649375 |
| Web of Science KeyUT | 000491886600014 |
| JaLCDOI | 10.18926/AMO/57370 |
|---|---|
| フルテキストURL | 73_5_403.pdf |
| 著者 | Ando, Akemi| Mitsuhashi, Toshiharu| Honda, Mitsugi| Hanayama, Yoshihisa| Hasegawa, Kou| Obika, Mikako| Kataoka, Hitomi| Otsuka, Fumio| |
| 抄録 | Osteoporosis increases the risk of bone fractures. It is diagnosed based on an individual’s bone mineral density (BMD) or a fracture without trauma. BMD is usually measured by the dual energy X-ray absorptiometry (DXA) method. Here we investigated factors for the earliest possible prediction of decreased BMD by examining the relationships between patients’ BMD values and changes in the patients’ physical and laboratory values. We retrospectively reviewed the medical records of 149 patients who visited our department in 2014-2015 for a variety of reasons and underwent an area BMD examination by DXA. We analyzed the relationships between decreasing BMD and the patients’ gender, age, body mass index (BMI), medical background, hemoglobin, electrolytes, and thyroid function. Thirty-nine of the patients were diagnosed with osteoporosis based on their T-scores. An adjusted analysis showed that female gender, aging, and increased serum calcium level were significantly related to decreasing femoral BMD, whereas high BMI was associated with an increase in femoral BMD. Collectively the results indicate that for the early detection of low BMD, it is important for general-practice physicians to consider conducting a BMD checkup when treating female and elderly patients with a low BMI and/or elevated serum calcium level. |
| キーワード | bone mineral density (BMD) body mass index (BMI) female gender hypercalcemia osteoporosis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-10 |
| 巻 | 73巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 403 |
| 終了ページ | 411 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31649366 |
| Web of Science KeyUT | 000491886600005 |
| JaLCDOI | 10.18926/AMO/57369 |
|---|---|
| フルテキストURL | 73_5_393.pdf |
| 著者 | Yi Yi Cho Thein| Win, Myitzu| Thuzara, Moe| Matsumoto, Hiroshi| Yamada, Kiyoshi| Kimata, Yoshihiro| Leung, Michael| |
| 抄録 | Although many surgical centers perform microsurgery routinely in developed countries, performing microsurgery is challenging in resource-poor developing countries, such as Myanmar. With the establishment of educational training programs and the assistance of volunteer plastic surgical teams, local plastic surgeons can learn the techniques of microsurgery and apply them clinically. The purpose of this study was to establish baseline data and define the challenges of performing microsurgery in Yangon General Hospital, Myanmar. Sixty-four patients underwent reconstruction with free flaps from January 2015 to January 2018. All clinical records of these cases were assessed. The number of free flap reconstructions performed increased from 11 in the first year to 24 in the third year. The anterolateral thigh flap was the most commonly used (42%). The most common sites of reconstruction were mandible and intraoral defects. Total flap survival occurred in 58 of 64 patients (89%). The total salvageable flap rate for revision surgery was 66.6%; the successful revision rate was highest in 2017, with fewer complications. The flap salvage rates increased and the operative duration decreased as clinical experience improved. Establishing a microsurgical center requires a strong multidisciplinary team, clinical experience, continuous learning, sensible clinical application, and effective interdepartmental and intradepartmental cooperation. |
| キーワード | microsurgery educational programs challenges of microsurgical free flaps reoperation flap salvageable rate |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-10 |
| 巻 | 73巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 393 |
| 終了ページ | 401 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31649365 |
| Web of Science KeyUT | 000491886600004 |
| JaLCDOI | 10.18926/AMO/57368 |
|---|---|
| フルテキストURL | 73_5_387.pdf |
| 著者 | Inoue, Miyabi| Yokoyama, Teruhiko| |
| 抄録 | To assess the efficacy and safety of 2 drugs for overactive bladder (OAB), solifenacin and mirabegron. Fortyseven female OAB patients were randomized into 2 groups. Twenty-three patients were initially prescribed solifenacin for 4 weeks, followed by mirabegron for 4 weeks (group S). The other 24 patients were initially prescribed mirabegron for 4 weeks, followed by solifenacin for 4 weeks (group M). Evaluations included clinical determination of the OAB symptom score (OABSS), International Prostate Symptom Score (IPSS), and Visual Analog Scale. The IPSS significantly improved after the administration of solifenacin in both groups. The OABSS significantly improved in both groups after 4 weeks. In group M, the OABSS after eight weeks was significantly improved compared to that after 4 weeks. However, in group S, it was not significantly improved. Twelve patients experienced adverse events during the solifenacin treatment, while 2 patients experienced adverse events during the mirabegron treatment. Both solifenacin and mirabegron led to improved OAB symptoms. Switching from mirabegron to solifenacin significantly improved the OABSS. However, mirabegron led to fewer adverse events than solifenacin. We recommend that mirabegron be prescribed first for OAB patients. If patients are not satisfied with mirabegron, solifenacin should be used. |
| キーワード | overactive bladder, randomized crossover study solifenacin mirabegron |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-10 |
| 巻 | 73巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 387 |
| 終了ページ | 392 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31649364 |
| Web of Science KeyUT | 000491886600003 |
| JaLCDOI | 10.18926/AMO/57367 |
|---|---|
| フルテキストURL | 73_5_383.pdf |
| 著者 | Fu, Li| Nishibori, Masahiro| |
| 抄録 | High mobility group box-1 (HMGB1) is a non-histone, DNA-binding nuclear protein belonging to the family of damage-associated molecular patterns (DAMPs). HMGB1 has been reported to play an important role during epileptogenesis although the mechanisms of its actions are still not clear. Many hypotheses have been suggested especially about the relationship between HMGB1 and inflammation responses and blood-brain barrier disruption during epileptogenesis. In this review, we will mainly discuss the role of HMGB1 in epileptogenesis. |
| キーワード | HMGB1 epileptogenesis inflammation blood-brain barrier |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-10 |
| 巻 | 73巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 383 |
| 終了ページ | 386 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31649363 |
| Web of Science KeyUT | 000491886600002 |
| JaLCDOI | 10.18926/AMO/57366 |
|---|---|
| フルテキストURL | 73_5_379.pdf |
| 著者 | Wake, Hidenori| |
| 抄録 | Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding and functional properties of HRG in sepsis. |
| キーワード | htidine-rich glycoprotein septic pathogenesis immunothrombosis |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-10 |
| 巻 | 73巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 379 |
| 終了ページ | 382 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31649362 |
| Web of Science KeyUT | 000491886600001 |
| フルテキストURL | SciRep_9_1_14001_p.pdf |
|---|---|
| 著者 | Uchiyama, Hironobu| Sasaki, Ken| Hinosawa, Shogo| Tanaka, Keisuke| Matsumura, Kentarou| Yajima, Shunsuke| Miyatake, Takahisa| |
| 発行日 | 2019-09-30 |
| 出版物タイトル | Scientific reports |
| 巻 | 9巻 |
| 号 | 1号 |
| 出版者 | Springer Nature |
| 開始ページ | 14001 |
| ISSN | 20452322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2019 |
| 論文のバージョン | publisher |
| PubMed ID | 31570743 |
| DOI | 10.1038/s41598-019-50440-5 |
| Web of Science KeyUT | 000488223900004 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-019-50440-5 |
| フルテキストURL | TL60_24_1562.pdf |
|---|---|
| 著者 | Kunishige, Takahiro| Sawada, Daisuke| |
| キーワード | Ketoxime Enamide synthesis Iron catalyst One-electron reduction |
| 備考 | This fulltext will be available in May 2021| |
| 発行日 | 2019-06-13 |
| 出版物タイトル | Tetrahedron Letters |
| 巻 | 60巻 |
| 号 | 24号 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE |
| 開始ページ | 1562 |
| 終了ページ | 1565 |
| ISSN | 00404039 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| DOI | 10.1016/j.tetlet.2019.05.006 |
| Web of Science KeyUT | 000495464900002 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.tetlet.2019.05.006 |
| フルテキストURL | Gastroenterology156_6_1753.pdf fig.pdf |
|---|---|
| 著者 | Tomoda, Takeshi| Kato, Hironari| Ueki, Toru| Akimoto, Yutaka| Hata, Hidenori| Fujii, Masakuni| Harada, Ryo| Ogawa, Tsuneyoshi| Wato, Masaki| Takatani, Masahiro| Matsubara, Minoru| Kawai, Yoshinari| Okada, Hiroyuki| |
| キーワード | Drug Inflammation Pancreas Smooth-Muscle Relaxant |
| 発行日 | 2019-05-31 |
| 出版物タイトル | Gastroenterology |
| 巻 | 156巻 |
| 号 | 6号 |
| 出版者 | W B SAUNDERS CO-ELSEVIER |
| 開始ページ | 1753 |
| 終了ページ | 1760 |
| ISSN | 00165085 |
| NCID | AA0065394X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 30772342 |
| DOI | 10.1053/j.gastro.2019.01.267 |
| Web of Science KeyUT | 10.1053/j.gastro.2019.01.267 |
| 関連URL | isVersionOf https://doi.org/10.1053/j.gastro.2019.01.267 |