| ID | 69226 |
| フルテキストURL | |
| 著者 |
Tani, Yoshinori
Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nakamura, Keiichiro
Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
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Yorimitsu, Masae
Department of Obstetrics and Gynecology, Hiroshima City Hiroshima Citizens Hospital
Seki, Noriko
Department of Obstetrics and Gynecology, Japanese Red Cross Society Himeji Hospital
Nakanishi, Mie
Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Itou, Hironori
Department of Obstetrics and Gynecology, National Hospital Organization Iwakuni Clinical Center
Shimizu, Miyuki
Department of Obstetrics and Gynecology, Kagawa Rosai Hospital
Yamamoto, Dan
Department of Obstetrics and Gynecology, National Organization Fukuyama Medical Center
Takahara, Etsuko
Department of Obstetrics and Gynecology, Fukuyama City Hospital
Masuyama, Hisashi
Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
publons
researchmap
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| 抄録 | Background In early-stage endometrial cancer (EC), the treatment of aggressive histological subtypes (endometrioid carcinoma grade 3, serous carcinoma, clear-cell carcinoma, undifferentiated carcinoma, mixed carcinoma, and carcinosarcoma) is controversial. We aimed to investigate the treatment of patients with International Federation of Gynecology and Obstetrics (FIGO) stage IC and stage IIC EC according to the 2023 classification.
Methods We retrospectively identified patients with FIGO 2023 stage IC, IIC-intermediate risk (IIC-I), and IIC-high risk (IIC-H) EC who underwent adjuvant therapy or observation after surgery at eight medical institutions from 2004 to 2023. Progression-free survival (PFS) and overall survival (OS) were evaluated using Kaplan–Meier estimates and univariate and multivariate analyses. Results The PFS and OS were significantly worse in patients with FIGO 2023 stage IIC-H EC than in those with FIGO 2023 stage IIC-I EC (PFS: p = 0.008 and OS: p = 0.006). According to the FIGO 2023 stage IIC-H classification, lymphadenectomy and chemotherapy resulted in better prognoses regarding both PFS and OS (p < 0.001 for both) than other treatments. Our findings suggest that lymphadenectomy and chemotherapy effectively reduced vaginal stump and lymph node metastases in FIGO 2023 stage IIC-H EC (p < 0.001 and p = 0.008, respectively). Furthermore, in the multivariate analysis, not undergoing lymphadenectomy or chemotherapy were independent predictors of recurrence and poor prognoses in patients with FIGO 2023 stage IIC-H EC (p < 0.001 and p = 0.031, respectively). Conclusion Lymphadenectomy and chemotherapy resulted in better prognoses regarding both recurrence and survival in patients with FIGO 2023 stage IIC high-risk EC. |
| キーワード | Endometrial cancer
FIGO 2023
Stage IIC high risk
Lymphadenectomy
Chemotherapy
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| 備考 | The version of record of this article, first published in International Journal of Clinical Oncology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10147-024-02647-4
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| 発行日 | 2024-11-09
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| 出版物タイトル |
International Journal of Clinical Oncology
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| 巻 | 30巻
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| 号 | 1号
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| 出版者 | Springer Science and Business Media LLC
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| 開始ページ | 144
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| 終了ページ | 156
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| ISSN | 1341-9625
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| NCID | AA11086579
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| 資料タイプ |
学術雑誌論文
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| 言語 |
英語
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| OAI-PMH Set |
岡山大学
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| 著作権者 | © The Author(s) 2024
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| 論文のバージョン | publisher
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| PubMed ID | |
| DOI | |
| Web of Science KeyUT | |
| 関連URL | isVersionOf https://doi.org/10.1007/s10147-024-02647-4
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| ライセンス | http://creativecommons.org/licenses/by/4.0/
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| Citation | Tani, Y., Nakamura, K., Yorimitsu, M. et al. Lymphadenectomy and chemotherapy are effective treatments for patients with 2023 international federation of gynecology and obstetrics stage IIC-high risk endometrial cancer in Japan. Int J Clin Oncol 30, 144–156 (2025). https://doi.org/10.1007/s10147-024-02647-4
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| 助成情報 |
( 国立大学法人岡山大学 / Okayama University )
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