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ID 30896
JaLCDOI
フルテキストURL
fulltext.pdf 1.16 MB
著者
Hayashi, Keiki Okayama University
Hsueh, Chao-Liang Okayama University
Kawasaki, Hideaki Okayama University
Toyofuku, Hiroyuki Okayama University
Miyashima, Takanao Okayama University
Awai, Michiyasu Okayama University
抄録

Renal tissues from 208 human necropsies were observed histologically for disseminated intravascular coagulation (DIC). The tissues were stained with hematoxylin-eosin, Mallory's phosphotungstic acid hematoxylin (PTAH) and cationic ferric hydroxide colloid stabilized with cacodylate (Fe-Cac), and tested by immunoenzyme histochemical (IEH) reaction for fibrin-related materials (FRMs). The use of the IEH method increased FRM recognition, and FRMs were detected in a total of 80 cases (38.5%). In 26 cases diagnosed clinically as DIC, FRMs were shown in 23 of the cases (88.5%). Thus, 57 patients with FRMs were clinically asymptomatic. In rats with DIC induced by endotoxin injection, glomerulus FRM was effluxed into the tubulus through the Bowman's capsule and was excreted into urine. The electric charge was reduced on the endothelial surface of the glomerular capillaries in both human and rat DIC. Under the scanning electron microscopy, the endothelial surface appeared coarse in the glomerular capillary and fibrin degradation was present. Our conclusions are: (a) PTAH is non-specific for FRMs, (b) IEH aids the pathohistological diagnosis of DIC, especially in asymptomatic forms including the compensated DIC state, (c) FRMs in tubuli suggest DIC, and (d) DIC is possibly initiated by a reduction in the capillary electric surface charge.

キーワード
disseminated intravascular coagulation
immunoenzyme-histochemistry
fibrinrelated materials
Amo Type
Article
出版物タイトル
Acta Medica Okayama
発行日
1989-02
43巻
1号
出版者
Okayama University Medical School
開始ページ
29
終了ページ
38
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
英語
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT