| ID | 40687 |
| フルテキストURL | |
| タイトル（別表記） | Studies on intractable factors in bronchial asthma Part 2. Effect of re-inhalation of antigen in the late asthmatic response in an animal model
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| 著者 |
沖 和彦
岡山大学医学部第二内科学教室
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| 抄録 | In investigating the etiological mechanisms of intractable asthma, ascaris suum was used as a sensitizing antigen in experimental animal models of re-inhalation in the late asthmatic response (LAR). Our results suggest that marked expiratory prolongation was caused by re-inhalation of the antigen in LAR. Moreover, the number of neutrophils and eosinophils increased in BALF after re-inhalation of the antigen more in LAR than in IAR (P<0.01). Finally the level of LTC4 and LTB4 increased in the venous blood and BABF after reinhalation during the LAR. The data suggests that cellular reactions among neutrophils, eosinophils, and other cells migrating into the airway lumen are seen in LAR, and moreover, LTC4 and LTB4 may be important chemical mediators in prolonged asthmatic attacks.
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| キーワード | Actively sensitized model
Late asthmatic response
Re-inhalation
BAL-cell
Leukotrienes
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| 発行日 | 1990-10
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| 出版物タイトル |
岡山医学会雑誌
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| 出版物タイトル（別表記） | Journal of Okayama Medical Association
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| 巻 | 102巻
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| 号 | 9-10号
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| 出版者 | 岡山医学会
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| 出版者（別表記） | Okayama Medical Association
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| 開始ページ | 1197
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| 終了ページ | 1205
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| ISSN | 0030-1558
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| NCID | AN00032489
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| 資料タイプ |
学術雑誌論文
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| オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/102/9-10/102_9-10_1197/_article/-char/ja/
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| 関連URL | http://www.okayama-u.ac.jp/user/oma/
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| 言語 |
日本語
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| 著作権者 | 岡山医学会
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| 論文のバージョン | publisher
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| 査読 |
有り
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| Eprints Journal Name | joma
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