検索結果 - 岡山大学学術成果リポジトリ

ザクセンの土地制度（３・完）

JaLCDOI	10.18926/OER62830
フルテキストURL	oer_053_2_043_064.pdf
著者	松尾展成\|
出版物タイトル	岡山大学経済学会雑誌
発行日	2021-11-10
巻	53巻
号	2号
開始ページ	43
終了ページ	64
ISSN	2433-4146
言語	日本語
著作権者	Copyright © 2021 岡山大学経済学会
論文のバージョン	publisher

海事産業強化法の特徴と今後の課題

JaLCDOI	10.18926/OER/62829
タイトル（別表記）	Characteristics and Issues of Strengthening Law on Maritime Industry
フルテキストURL	oer_053_2_027_041.pdf
著者	津守貴之\|
出版物タイトル	岡山大学経済学会雑誌
発行日	2021-11-10
巻	53巻
号	2号
開始ページ	27
終了ページ	41
ISSN	2433-4146
言語	日本語
著作権者	Copyright © 2021 岡山大学経済学会
論文のバージョン	publisher

倉敷市における地域公共政策の支援活動

JaLCDOI	10.18926/OER/62828
タイトル（別表記）	Support activities for regional public policy in Kurashiki City
フルテキストURL	oer_053_2_001_025.pdf
著者	三村聡\|
抄録	平成23（2011）年に設立された「岡山大学地域総合研究センター」は、通称「AGORA（広場）」と呼ばれ、地域コミュニティにおける「市民参加や市民協働」、「地域共存・地域共生」を推進、実践するために、多様な人が集い、みなで熟議し、直面する社会課題を解決することを使命とした全学センターである。そこではシンクタンク機能を果たしながら、併せて、学生の地域社会における活動や教育カリキュラム作りを支援する活動を続けてきた。令和３（2021）年は設立10年目を迎えるため、拙者が担当した倉敷市に係る活動の概要を紹介することにより、同センターの小括として記録に留める。
出版物タイトル	岡山大学経済学会雑誌
発行日	2021-11-10
巻	53巻
号	2号
開始ページ	1
終了ページ	25
ISSN	2433-4146
言語	日本語
著作権者	Copyright © 2021 岡山大学経済学会
論文のバージョン	publisher

表紙・目次

フルテキストURL	oer_053_2_contents.pdf
出版物タイトル	岡山大学経済学会雑誌
発行日	2021-11-10
巻	53巻
号	2号
ISSN	2433-4146
言語	日本語
著作権者	Copyright © 2021 岡山大学経済学会
論文のバージョン	publisher

Relationship between clinical outcomes and nerve conduction studies before and after surgery in patients with carpal tunnel syndrome

フルテキストURL	fulltext.pdf
著者	Ise, Masato\| Saito, Taichi\| Katayama, Yoshimi\| Nakahara, Ryuichi\| Shimamura, Yasunori\| Hamada, Masanori\| Senda, Masuo\| Ozaki, Toshifumi\|
キーワード	Carpal tunnel syndrome Nerve conduction study The disability of the arm shoulder and hand questionnaire Clinical outcomes
発行日	2021-10-16
出版物タイトル	BMC Musculoskeletal Disorders
巻	22巻
号	1号
出版者	BMC
開始ページ	882
ISSN	1471-2474
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021.
論文のバージョン	publisher
PubMed ID	34656102
DOI	10.1186/s12891-021-04771-y
Web of Science KeyUT	000707702900001
関連URL	isVersionOf https://doi.org/10.1186/s12891-021-04771-y

Repurposing of posaconazole as a hedgehog/SMO signaling inhibitor for embryonal rhabdomyosarcoma therapy

フルテキストURL	fulltext.pdf
著者	Sun, Jingkai\| Lin, Wenfeng\| Li, Chaoming\| Ueki, Hideo\| Xue, Ruizhi\| Sadahira, Takuya\| Hu, Hao\| Wada, Koichiro\| Li, Na\| Liu, Chunxiao\| Araki, Motoo\| Xu, Abai\| Huang, Peng\|
キーワード	Posaconazole cell cycle autophagy rhabdomyosarcoma hedgehog proteins
発行日	2021-09-30
出版物タイトル	American Journal of Cancer Research
巻	11巻
号	9号
出版者	e-Century Publishing Corporation
開始ページ	4528
終了ページ	4540
ISSN	2156-6976
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	AJCR (c)2021 e-Century Publishing Corp.
論文のバージョン	publisher
PubMed ID	34659903
Web of Science KeyUT	000707716300029

Veno-venous extracorporeal membrane oxygenation in the management of refractory bilateral bronchial dehiscence after lung transplant: a case report

フルテキストURL	fulltext.pdf
著者	Tani, Makiko\|
キーワード	Bronchial dehiscence Extracorporeal membrane oxygenation Lung transplant
発行日	2021-10-16
出版物タイトル	JA CClinical Reports
巻	7巻
号	1号
出版者	Springer
開始ページ	77
ISSN	2363-9024
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021.
論文のバージョン	publisher
PubMed ID	34654984
DOI	10.1186/s40981-021-00480-6
Web of Science KeyUT	000707577000001
関連URL	isVersionOf https://doi.org/10.1186/s40981-021-00480-6

Production of TRPM4 knockout cell line using rat cardiomyocyte H9c2

フルテキストURL	fulltext.pdf Corrigendum.pdf
著者	Wang, Chen\| Maeda, Masakazu\| Chen, Jian\| Wang, Mengxue\| Naruse, Keiji\| Takahashi, Ken\|
キーワード	TRPM4 Cardiomyocyte H9c2 CRISPR/Cas9 Confocal microscopy DNA sequencing Flow cytometry Western blotting
発行日	2021
出版物タイトル	MethodsX
巻	8巻
出版者	ELSEVIER
開始ページ	101404
ISSN	2215-0161
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Authors.
論文のバージョン	publisher
PubMed ID	34430300
DOI	10.1016/j.mex.2021.101404
Web of Science KeyUT	000707187100026
関連URL	isVersionOf https://doi.org/10.1016/j.mex.2021.101404

Electrical Resistivity of Cu and Au at High Pressure above 5 GPa: Implications for the Constant Electrical Resistivity Theory along the Melting Curve of the Simple Metals

フルテキストURL	fulltext.pdf
著者	Ezenwa, Innocent C.\| Yoshino, Takashi\|
キーワード	electrical resistivity thermal conductivity electrons and phonons interactions high pressure and temperature constant resistivity melting curve
発行日	2021-09-22
出版物タイトル	Materials
巻	14巻
号	19号
出版者	MDPI
開始ページ	5476
ISSN	1996-1944
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors.
論文のバージョン	publisher
PubMed ID	34639875
DOI	10.3390/ma14195476
Web of Science KeyUT	000707452700001
関連URL	isVersionOf https://doi.org/10.3390/ma14195476

Clinical Efficacy and Safety of Sitafloxacin 200 mg Once Daily for Refractory Genitourinary Tract Infections

JaLCDOI	10.18926/AMO/62820
フルテキストURL	75_6_763.pdf
著者	Iwata, Takehiro\| Sadahira, Takuya\| Maruyama, Yuki\| Sekito, Takanori\| Yoshinaga, Kasumi\| Watari, Shogo\| Nagao, Kentaro\| Kawada, Tatsushi\| Tominaga, Yusuke\| Nishimura, Shingo\| Takamoto, Atsushi\| Sako, Tomoko\| Edamura, Kohei\| Kobayashi, Yasuyuki\| Araki, Motoo\| Ishii, Ayano\| Watanabe, Masami\| Watanabe, Toyohiko\| Nasu, Yasutomo\| Wada, Koichiro\|
抄録	The aim of this ongoing trial is to evaluate the clinical efficacy and safety of sitafloxacin (STFX) 200 mg once daily (QD) for 7 days in patients with refractory genitourinary tract infections, which include recurrent or complicated cystitis, complicated pyelonephritis, bacterial prostatitis, and epididymitis. The primary endpoint is the microbiological efficacy at 5-9 days after the last administration of STFX. Recruitment began in February 2021, and the target total sample size is 92 participants.
キーワード	genitourinary tract infections fluoroquinolone resistance extended-spectrum beta-lactamase
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	763
終了ページ	766
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955548
Web of Science KeyUT	000735319800006
NAID	120007180272

Pulmonary Enteric Adenocarcinoma Harboring a BRAF G469V Mutation

JaLCDOI	10.18926/AMO/62819
フルテキストURL	75_6_759.pdf
著者	Shimizu, Dai\| Yamamoto, Hiromasa\| Shien, Kazuhiko\| Taniguchi, Kohei\| Miyoshi, Kentaroh\| Namba, Kei\| Mesaki, Kumi\| Sugimoto, Seiichiro\| Soh, Junichi\| Yamane, Masaomi\| Toyooka, Shinichi\|
抄録	Pulmonary enteric adenocarcinoma (PEAC) is a rare subtype of lung cancer that should be differentiated from colorectal cancer metastasis. Little is known about its genetic background. An 84-year-old male with adenocarcinoma of the lung underwent left upper lobectomy. The histology of the surgical specimen was suggestive of PEAC. Gastrointestinal and colorectal fiberscopy revealed no evidence of colorectal cancer. Next-generation sequencing of the tumor identified a G469V substitution in serine/threonine-protein kinase B-raf (BRAF). Based on the higher prevalence of the G469 substitution in BRAF-mutant lung adenocarcinoma than in BRAFmutant colorectal cancer, the tumor likely originated from the lung. Identification of mutational genotype may be of some help in distinguishing PEAC from the lung metastasis of colorectal cancer.
キーワード	non-small cell lung cancer somatic mutations pulmonary adenocarcinoma with enteric differentiation non-V600E BRAF mutation next-generation sequencing
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	759
終了ページ	762
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955547
Web of Science KeyUT	000735319800005
NAID	120007180273

Left Hemihepatectomy for Hepatocellular Carcinoma Following Esophagectomy with Retrosternal Gastric Tube Reconstruction for Esophageal Cancer

JaLCDOI	10.18926/AMO/62818
フルテキストURL	75_6_755.pdf
著者	Takagi, Kosei\| Kuise, Takashi\| Umeda, Yuzo\| Yoshida, Ryuichi\| Yoshida, Kazuhiro\| Nagai, Yasuo\| Noma, Kazuhiro\| Tanabe, Shunsuke\| Maeda, Naoaki\| Yagi, Takahito\| Fujiwara, Toshiyoshi\|
抄録	Approximately 4% of patients with esophageal cancer develop a second primary malignancy in the upper gastrointestinal trunk. However, hepatectomy following esophagectomy for esophageal cancer has rarely been reported. We report the case of a 70-year-old man who underwent an esophagectomy for esophageal cancer with retrosternal gastric tube reconstruction. Nine years later, he developed hepatocellular carcinoma with tumor thrombus involving the left portal vein, and was successfully treated with left hemihepatectomy. Special attention should be paid to avoiding incidental injury of the gastric tube as well as the right gastroepiploic artery during the hepatectomy.
キーワード	liver resection, esophagectomy, retrosternal gastric tube reconstruction
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	755
終了ページ	758
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955546
Web of Science KeyUT	000735319800004
NAID	120007180274

Novel Technique for Removing a Well-Fixed Cemented Cup with a Dedicated Original Device during Revision Total Hip Arthroplasty: Surgical Technique

JaLCDOI	10.18926/AMO/62817
フルテキストURL	75_6_751.pdf
著者	Endo, Hirosuke\| Yamada, Kazuki\| Testunaga, Tomonori\| Furumatsu, Takayuki\| Mitani, Shigeru\| Ozaki, Toshifumi\|
抄録	The improved cemented cup technique has attained excellent long-term results in primary total hip arthroplasty. When cup revision surgery was performed, the cemented cup, which was loosened at the bone-cement interface, was easily removed. However, with a well-fixed bone-cement interface, it remains difficult to remove the cemented cup for a revision in the event of a recurring dislocation. In addition, protrusions in the cement can cause unpredictable bone defects. A new removal device was created and used successfully to remove a well-fixed cemented cup safely and efficiently. This report introduces the device and the technique used in cemented cup removal.
キーワード	total hip arthroplasty revision surgery well-fixed cemented cup
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	751
終了ページ	754
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955545
Web of Science KeyUT	000735319800003
NAID	120007180275

Non-Invasive Prenatal Genetic Testing (NIPT) Leading to Prenatal Diagnosis of Trisomy 21 Mosaicism and 18q Deletion Syndrome: Two Cases

JaLCDOI	10.18926/AMO/62816
フルテキストURL	75_6_745.pdf
著者	Hayata, Kei\| Mishima, Sakurako\| Ohira, Akiko\| Tani, Kazumasa\| Maki, Jota\| Eto, Eriko\| Ogawa, Chikako\| Masuyama, Hisashi\|
抄録	NIPT is non-definitive testing to estimate the possibility that fetuses have trisomy 21, trisomy 18, or trisomy 13. However, in NIPT-positive and indeterminate cases, rare chromosomal disease may become apparent, requiring advanced genetic considerations and counseling skills. We experienced two such cases, a trisomy 21 mosaicism case triggered by NIPT-positive status and 18q deletion syndrome triggered by NIPT-indeterminate status. These cases have two clinical implications for NIPT. First, it was revealed that trisomy mosaicism might be found in NIPT-positive cases that have lower Z-Scores than those inferred from the fraction of fetal cfDNA in the case of standard trisomy. Second, it is possible that microdeletion syndrome could be the reason for an indeterminate NIPT result. Today’s genetic counseling requires more expertise in ethics and communication as well as genetic science because NIPT can lead to totally unexpected results.
キーワード	NIPT massively parallel sequencing trisomy 21 mosaicism 18q-deletion syndrome genetic counseling
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	745
終了ページ	750
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955544
Web of Science KeyUT	000735319800002
NAID	120007180276

Sublingual Gland Carcinoma Revealed by Choroidal Metastasis

JaLCDOI	10.18926/AMO/62815
フルテキストURL	75_6_741.pdf
著者	Morita, Tetsuro\| Shiode, Yusuke\| Kimura, Shuhei\| Hosokawa, Mio\| Doi, Shinichiro\| Takahashi, Kosuke\| Matoba, Ryo\| Kanzaki, Yuki\| Tabata, Masahiro\| Morizane, Yuki\|
抄録	A 65-year-old man presented with a 1-week history of left eye distortion. An elevated choroidal lesion covering 6 disc diameters was found in the posterior retina of the left eye. Systemic examination revealed sublingual gland carcinoma and multiple lung metastases, and the diagnosis was choroidal metastasis from sublingual gland carcinoma. Following chemotherapy and radiation therapy, the choroidal lesion shrunk and the patient’s visual acuity improved. The patient died 23 months after his first visit. To the best of our knowledge, this is the first reported case of choroidal metastasis from sublingual gland carcinoma.
キーワード	adenoid cystic carcinoma choroidal metastasis sublingual gland
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	741
終了ページ	744
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955543
Web of Science KeyUT	000735319800001
NAID	120007180277

Multiple Hepatolithiasis Following Hepaticojejunostomy Successfully Treated with Left Hemihepatectomy and Double Hepaticojejunostomy Reconstruction

JaLCDOI	10.18926/AMO/62814
フルテキストURL	75_6_735.pdf
著者	Nagai, Yasuo\| Takagi, Kosei\| Kuise, Takashi\| Umeda, Yuzo\| Yoshida, Ryuichi\| Yoshida, Kazuhiro\| Yasui, Kazuya\| Yagi, Takahito\| Fujiwara, Toshiyoshi\|
抄録	Surgical intervention for hepatolithiasis following hepaticojejunostomy (HJ) has rarely been reported. Herein, we present a case of post-HJ multiple hepatolithiasis treated with left hemihepatectomy with double HJ reconstruction. A 72-year-old woman who had undergone HJ for iatrogenic bile duct injury developed repeated cholangitis due to complicated hepatolithiasis accompanied by an atrophied left hepatic lobe and HJ stricture. Since endoscopic intervention was unsuccessful, the patient underwent left hemihepatectomy with HJ re-anastomoses of the common hepatic duct and left hepatic duct (double HJ technique). The double HJ technique with hepatectomy can be a useful option for treating complicated hepatolithiasis following HJ.
キーワード	hepatolithiasis hepaticojejunostomy hepatectomy
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	735
終了ページ	739
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955542
Web of Science KeyUT	000735297900009
NAID	120007180278

Morphological Changes and Durability of Skin and Mucosal Flaps in Intraoral and Pharyngeal Reconstructions: Long-term Follow-up and Literature Review for Potential Second Carcinomas

JaLCDOI	10.18926/AMO/62813
フルテキストURL	75_6_725.pdf
著者	Matsumoto, Hiroshi\| Kimata, Yoshihiro\| Ota, Tomoyuki\| Sugiyama, Narushi\| Onoda, Satoshi\| Makino, Takuma\| Takeda, Seiko\| Mizukawa, Nobuyoshi\|
抄録	The long-term changes in tissues implanted in the oral cavity and pharynx after head and neck reconstruction have not been fully evaluated. This study aimed to clarify the morphological changes, long-term durability, and potential for secondary carcinogenesis in such tissues. In our single-center study, the rough morphological changes in 54 cases of intraoral and pharyngeal skin and mucosal flaps were evaluated more than 10 years after flap transfer. In addition, the literature on the development of second carcinomas from skin flaps was reviewed. The mean follow-up period for transferred flaps was 148 months. The reconstruction areas and the probability of morphological changes were significantly correlated (p=0.006), especially in cases with tongue, lower gingiva, and buccal mucosal reconstruction. Free jejunal flap surfaces were well maintained, whereas tubed skin flaps showed severe morphological changes in cases with pharyngeal reconstruction. None of the flaps in our series developed second primary carcinomas. Skin flaps generally had good durability for > 10 years in intraoral environments, while mucosal flaps had better durability for pharyngeal reconstruction. Second squamous carcinomas arising from skin flaps are extremely rare; however, surgeons should take this possibility into consideration and conduct meticulous and long-term follow-up.
キーワード	skin flap mucosal flap oral reconstruction morphological change second primary carcinoma
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	725
終了ページ	734
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955541
NAID	120007180279

The Significance of Age and Causative Bacterial Morphology in the Choice of an Antimicrobial Agent to Treat Acute Uncomplicated Cystitis

JaLCDOI	10.18926/AMO/62812
フルテキストURL	75_6_719.pdf
著者	Uehara, Shinya\| Fujio, Kei\| Yamasaki, Tomoya\| Otsuki, Hideo\|
抄録	Differentiating patients by age and causative bacterial morphology might aid in making the appropriate choice of antimicrobial agent when treating acute uncomplicated cystitis. In this retrospective analysis, the non-susceptibility rates of the causative bacteria to cefcapene-pivoxil (CFPN-PI) and levofloxacin (LVFX) were determined after dividing patients with acute uncomplicated cystitis by age group (15-54 and 55-74 years old) and by bacterial morphology: gram-positive cocci (GPC) or gram-negative rod (GNR). The overall non-susceptibility rates for CFPN-PI and LVFX were 19.4% and 15.3%, respectively. When the subjects were divided by age, only the non-susceptibility rate for LVFX in the younger group significantly decreased (to 8.7%). When the groups were divided by both age and bacterial morphology, the younger GNR group had non-susceptibility rates of 6.9% to CFPN-PI and 7.8% to LVFX, whereas the younger GPC group showed 10.2% non-susceptibility to LVFX. The older GNR group showed 9.8% non-susceptibility to CFPN-PI, while the older GPC group showed 7.2% non-susceptibility to LVFX. All the non-susceptibility rates were lower than 10.2% in the sub-divided groups. Differentiating patients by age and the morphology of causative bacteria can aid in making the appropriate choice of antimicrobial agent and may improve treatment outcomes in patients with acute uncomplicated cystitis.
キーワード	acute uncomplicated cystitis oral antimicrobial agents antimicrobial susceptibility menopause Gram stain
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	719
終了ページ	724
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955540
Web of Science KeyUT	000735297900008
NAID	120007180280

Correlations Among Consistency, Computed Tomography Values, and Histopathological Subtypes of Spinal Meningioma

JaLCDOI	10.18926/AMO/62811
フルテキストURL	75_6_713.pdf
著者	Aoyama, Tatsuro\| Ogiwara, Toshihiro\| Ito, Kiyoshi\| Miyaoka, Yoshinari\| Fujii, Yu\| Hanaoka, Yoshiki\| Hasegawa, Takatoshi\| Watanabe, Gen\| Seguchi, Tatsuya\| Hongo, Kazuhiro\|
抄録	The consistency of spinal meningiomas is important to consider when performing tumor removal surgery. This study evaluated the correlations between spinal meningioma consistency and both preoperative computed tomography (CT) values and histopathological subtypes. Fifteen consecutive patients who underwent surgical resection of spinal meningioma at our institution were identified, and preoperative CT values and the signal intensity of T2-weighted magnetic resonance images of the tumor were determined retrospectively. The consistency of the spinal meningioma was defined based on the ultrasonic surgical aspirator output during tumor debulking. Patients were assigned to 2 groups: a soft group (n=4) and a hard group (n=11). The T2 signal intensity was significantly higher in the soft group than in the hard group (p=0.001). While the CT values were considerably higher in the hard group, the difference was not significant (p=0.19). Regarding the histopathological subtypes, psammomatous meningioma exhibited significantly higher CT values than meningothelial meningioma (p=0.019); however, there was a higher frequency of hard tumors in meningothelial meningioma cases than in psammomatous meningioma cases. Although neither robust correlations between tumor consistency and CT values nor a relationship between tumor consistency and histopathological subtype has been established, these results might help with the perioperative manegement of spinal tumors.
キーワード	calcification computed tomography psammoma body spinal meningioma
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	713
終了ページ	718
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955539
Web of Science KeyUT	000735297900007
NAID	120007180281

Testosterone Recovery after Neoadjuvant Gonadotropin-Releasing Hormone Antagonist versus Agonist on Permanent Iodine-125 Seed Brachytherapy in Prostate Cancer Patients: A Propensity Score Analysis

JaLCDOI	10.18926/AMO/62810
フルテキストURL	75_6_705.pdf
著者	Iwata, Takehiro\| Maruyama, Yuki\| Kawada, Tatsushi\| Sadahira, Takuya\| Katayama, Satoshi\| Takamoto, Atsushi\| Sako, Tomoko\| Wada, Koichiro\| Edamura, Kohei\| Kobayashi, Yasuyuki\| Araki, Motoo\| Watanabe, Masami\| Watanabe, Toyohiko\| Nasu, Yasutomo\|
抄録	Optimal neoadjuvant hormone therapy (NHT) for reducing prostate cancer (PC) patients’ prostate volume pre-brachytherapy is controversial. We evaluated the differential impact of neoadjuvant gonadotropin-releasing hormone (GnRH) antagonist versus agonist on post-brachytherapy testosterone recovery in 112 patients treated pre-brachytherapy with NHT (GnRH antagonist, n=32; GnRH agonists, n=80) (Jan. 2007-June 2019). We assessed the effects of patient characteristics and a GnRH analogue on testosterone recovery with logistic regression and a propensity score analysis (PSA). There was no significant difference in the rate of testosterone recovery to normal levels (> 300 ng/dL) between the GnRH antagonist and agonists (p=0.07). The GnRH agonists induced a significantly more rapid testosterone recovery rate at 3 months post-brachytherapy versus the GnRH antagonist (p<0.0001); there was no difference in testosterone recovery at 12 months between the GnRH antagonist/agonists (p=0.8). In the multivariate analysis, no actor was associated with testosterone recovery. In the PSA, older age and higher body mass index (BMI) were significantly associated with longer testosterone recovery. Post-brachytherapy testosterone recovery was quicker with the neoadjuvant GnRH agonists than the antagonist, and the testosterone recovery rate was significantly associated with older age and higher BMI. Long-term follow-ups are needed to determine any differential effects of GnRH analogues on the quality of life of brachytherapy-treated PC patients.
キーワード	testosterone recovery GnRH antagonist GnRH agonist brachytherapy prostate cancer
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	705
終了ページ	711
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955538
Web of Science KeyUT	000735297900006
NAID	120007180282