| ID | 40646 |
| フルテキストURL | |
| タイトル（別表記） | Study of mitochondrial activity (Rhodamine 123 uptake) on Ehrlich ascites tumor cells and its adriamycin resistant cells
|
| 著者 |
岡崎 良夫
岡山大学医学部放射線医学教室
|
| 抄録 | The positively charged fluorescent dye Rhodamine 123 (Rho 123) accumulates in mitochondria. An adriamycin (ADR)-resistant cell line derived from Ehrlich ascites tumor cells (wild EATC) was established in our laboratory. Overall mitochondrial activity of wild EATC and ADR-resistant EATC was investigated by the staining method with Rho 123. The uptake of Rho 123 into living cells was analyzed by flow cytometry. The intracellular Rho 123 uptake of ADR-resistant EATC was lower than that of wild EATC. The intracellular Rho 123 uptake of wild EATC increased when cells were treated with cepharanthine (CP). The intracellular Rho 123 uptake of ADR-resistant EATC increased markedly by CP treatment. ADR-resistant EATC cosumed more endogenous oxygen than wild EATC. The energy level of ADR-resistant EATC was discussed.
|
| キーワード | アドリアマイシン (ADR)
ADR耐性細胞
ミトコンドリア
Rhodamine 123
ハイパーサーミア
|
| 発行日 | 1990-06
|
| 出版物タイトル |
岡山医学会雑誌
|
| 出版物タイトル（別表記） | Journal of Okayama Medical Association
|
| 巻 | 102巻
|
| 号 | 5-6号
|
| 出版者 | 岡山医学会
|
| 出版者（別表記） | Okayama Medical Association
|
| 開始ページ | 779
|
| 終了ページ | 788
|
| ISSN | 0030-1558
|
| NCID | AN00032489
|
| 資料タイプ |
学術雑誌論文
|
| オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/102/5-6/102_5-6_779/_article/-char/ja/
|
| 関連URL | http://www.okayama-u.ac.jp/user/oma/
|
| 言語 |
日本語
|
| 著作権者 | 岡山医学会
|
| 論文のバージョン | publisher
|
| 査読 |
有り
|
| Eprints Journal Name | joma
|
