検索結果 - 岡山大学学術成果リポジトリ

Formation of Hot Ice Caused by Carbon Nanobrushes

フルテキストURL	J_ChemPhys_151_064702_p.pdf
著者	Yagasaki, Takuma\| Yamasaki, Masaru\| Matsumoto, Masakazu\| Tanaka, Hideki\|
備考	This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Takuma Yagasaki et. al. Formation of hot ice caused by carbon nanobrushes. The Journal of Chemical Physics 151(6), 064702 (2019)(citation of published article) and may be found at https://doi.org/10.1063/1.5111843.\|
発行日	2019-08-08
出版物タイトル	The Journal of Chemical Physics
巻	151巻
号	6号
出版者	American Institute of Physics
開始ページ	064702
ISSN	00219606
NCID	AA00694991
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	Copyright (2019) Author(s)
論文のバージョン	publisher
DOI	10.1063/1.5111843
関連URL	isVersionOf https://doi.org/10.1063/1.5111843

A Bayesian approach for identification of ice Ih, ice Ic, high density, and low density liquid water with a torsional order parameter

フルテキストURL	J_Chem_Phys_150_21_214504.pdf J_Chem_Phys_150_21_214504_p.pdf
著者	Matsumoto, Masakazu\| Yagasaki, Takuma\| Tanaka, Hideki\|
発行日	2019-06-05
出版物タイトル	Journal of Chemical Physics
巻	150巻
号	21号
出版者	American Institute of Physics
開始ページ	214504
ISSN	0021-9606
NCID	AA00694991
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	Copyright 2019 Author(s).
論文のバージョン	author
PubMed ID	31176318
DOI	10.1063/1.5096556
関連URL	isVersionOf https://doi.org/10.1063/1.5096556

Breastfeeding and risk of food allergy: A nationwide birth cohort in Japan

フルテキストURL	Allergol_Int_201908007.pdf
著者	Matsumoto, Naomi\| Yorifuji, Takashi\| Nakamura, Kazue\| Ikeda, Masanori\| Tsukahara, Hirokazu\| Doi, Hiroyuki\|
キーワード	Breastfeeding Cohort Colostrum Eczema Food allergy
発行日	2019-09-17
出版物タイトル	Allergology International
出版者	Elsevier
ISSN	13238930
NCID	AA11091750
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 Japanese Society of Allergology. Production and hosting by Elsevier B.V.
論文のバージョン	publisher
PubMed ID	31540813
DOI	10.1016/j.alit.2019.08.007
関連URL	isVersionOf https://doi.org/10.1016/j.alit.2019.08.007

Behavioural effects of inhalation exposure to dizocilpine (MK-801) in mice

フルテキストURL	Biomed_Pharmacother_2019109038.pdf
著者	Ueno, Hiroshi\| Suemitsu, Shunsuke\| Murakami, Shinji\| Kitamura, Naoya\| Wani, Kenta\| Takahashi, Yu\| Matsumoto, Yosuke\| Okamoto, Motoi\| Ishihara, Takeshi\|
キーワード	Inhalation Dizocilpine MK-801 Mouse Drug Schizophrenia
発行日	2019-09-30
出版物タイトル	Biomedicine & Pharmacotherapy
巻	117巻
出版者	Elsevier
開始ページ	109038
ISSN	07533322
NCID	AA10506249
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 The Authors. Published by Elsevier Masson SAS.
論文のバージョン	publisher
PubMed ID	31177060
DOI	10.1016/j.biopha.2019.109038
Web of Science KeyUT	000477804500018
関連URL	isVersionOf https://doi.org/10.1016/j.biopha.2019.109038

A proposed simple screening method to determine relative contributions of CYP3A4 and CYP3A5 to drug metabolism in vitro

フルテキストURL	PMU8_41.pdf Fig.pdf Suppl.pdf
著者	Matsumoto, Jun\| Nakamura, Hiroyoshi\| San, Su Nwe\| Sato, Hikari\| Takezawa, Manami\| Kishi, Ryuto\| Kito, Yutaro\| Sugano, Junko\| Izuki, Mai\| Yanagisawa, Nao\| Ikeda, Naoki\| Saito, Yusuke\| Kato, Yoshinori\| Yamada, Harumi\| Fujiyoshi, Masachika\| Ariyoshi, Noritaka\|
キーワード	CYP3A CYP3A5*3 allele P450 Glo Assay system Pharmacokinetics Pharmacogenetics
発行日	2019-07-31
出版物タイトル	Personalized Medicine Universe
巻	8巻
出版者	Elsevier B.V.
開始ページ	41
終了ページ	44
ISSN	21867070
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
DOI	10.1016/j.pmu.2019.04.001
関連URL	isVersionOf https://doi.org/10.1016/j.pmu.2019.04.001

Comprehensive behavioral study of the effects of vanillin inhalation in mice

フルテキストURL	fulltext.pdf
著者	Ueno, Hiroshi\| Shimada, Atsumi\| Suemitsu, Shunsuke\| Murakami, Shinji\| Kitamura, Naoya\| Wani, Kenta\| Takahashi, Yu\| Matsumoto, Yosuke\| Okamoto, Motoi\| Fujiwara, Yuko\| Ishihara, Takeshi\|
キーワード	Anti-nociceptive Vanillin Essential oil Inhalation Analgesia
発行日	2019-07
出版物タイトル	Biomedicine and Pharmacotherapy
巻	115巻
出版者	Elsevier
開始ページ	108879
ISSN	0753-3322
NCID	AA10506249
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 The Authors.
論文のバージョン	publisher
PubMed ID	31035009
DOI	10.1016/j.biopha.2019.108879
Web of Science KeyUT	000470664600018
関連URL	isVersionOf https://doi.org/10.1016/j.biopha.2019.108879

Layer-specific expression of extracellular matrix molecules in the mouse somatosensory and piriform cortices

フルテキストURL	fulltext.pdf
著者	Ueno, Hiroshi\| Suemitsu, Shunsuke\| Murakami, Shinji\| Kitamura, Naoya\| Wani, Kenta\| Matsumoto, Yosuke\| Okamoto, Motoi\| Ishihara, Takeshi\|
キーワード	Extracellular matrix Perineuronal nets Piriform cortex Proteoglycans Somatosensory cortex Wisteria floribunda
発行日	2019-06
出版物タイトル	IBRO Reports
巻	6巻
出版者	Elsevier
開始ページ	1
終了ページ	17
ISSN	24518301
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2018 The Authors.
論文のバージョン	publisher
PubMed ID	30582064
DOI	10.1016/j.ibror.2018.11.006
関連URL	isVersionOf https://doi.org/10.1016/j.ibror.2018.11.006

Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice

フルテキストURL	fulltext.pdf
著者	Ueno, Hiroshi\| Shimada, Atsumi\| Suemitsu, Shunsuke\| Murakami, Shinji\| Kitamura, Naoya\| Wani, Kenta\| Matsumoto, Yosuke\| Okamoto, Motoi\| Fujiwara, Yuko\| Ishihara, Takeshi\|
キーワード	Neuroscience Physiology
発行日	2019-06
出版物タイトル	Heliyon
巻	5巻
号	6号
出版者	Elsevier
開始ページ	e01945
ISSN	2405-8440
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 The Authors.
論文のバージョン	publisher
PubMed ID	31431930
DOI	10.1016/j.heliyon.2019.e01945
Web of Science KeyUT	000473818300016
関連URL	isVersionOf https://doi.org/10.1016/j.heliyon.2019.e01945

Second nationwide surveillance of bacterial pathogens in patients with acute uncomplicated cystitis conducted by Japanese Surveillance Committee from 2015 to 2016: antimicrobial susceptibility of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus saprophyticus

フルテキストURL	fulltext.pdf
著者	Hayami, Hiroshi\| Takahashi, Satoshi\| Ishikawa, Kiyohito\| Yasuda, Mitsuru\| Yamamoto, Shingo\| Wada, Koichiro\| Kobayashi, Kanao\| Hamasuna, Ryoichi\| Minamitani, Shinichi\| Matsumoto, Tetsuya\| Kiyota, Hiroshi\| Tateda, Kazuhiro\| Sato, Junko\| Hanaki, Hideaki\| Masumori, Naoya\| Nishiyama, Hiroyuki\| Miyazaki, Jun\| Fujimoto, Kiyohide\| Tanaka, Kazushi\| Uehara, Shinya\| Matsubara, Akio\| Ito, Kenji\| Hayashi, Kenji\| Kurimura, Yuichiro\| Ito, Shin\| Takeuchi, Toshimi\| Narita, Harunori\| Izumitani, Masanobu\| Nishimura, Hirofumi\| Kawahara, Motoshi\| Hara, Makoto\| Hosobe, Takahide\| Takashima, Kenji\| Chokyu, Hirofumi\| Matsumura, Masaru\| Ihara, Hideari\| Uno, Satoshi\| Monden, Koichi\| Sumii, Toru\| Kawai, Shuichi\| Kariya, Satoru\| Sato, Takashi\| Yoshioka, Masaru\| Kadena, Hitoshi\| Matsushita, Shinji\| Nishi, Shohei\| Hosokawa, Yukinari\| Shirane, Takeshi\| Yoh, Mutsumasa\| Watanabe, Syuji\| Makinose, Shinichi\| Uemura, Tetsuji\| Goto, Hirokazu\|
キーワード	Surveillance Susceptibility Resistance Acute uncomplicated cystitis
発行日	2019-06
出版物タイトル	Journal of Infection and Chemotherapy
巻	25巻
号	6号
出版者	Elsevier
開始ページ	413
終了ページ	422
ISSN	1341-321X
NCID	AA11057978
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
論文のバージョン	publisher
PubMed ID	30905628
DOI	10.1016/j.jiac.2019.02.021
Web of Science KeyUT	000466427000002
関連URL	isVersionOf https://doi.org/10.1016/j.jiac.2019.02.021

Ventralight ST®を用いて腹腔鏡下手術で修復した Morgagni 孔ヘルニアの1例

タイトル（別表記）	A Morgagni hernia repaired laparoscopically using Ventralight ST® mesh
フルテキストURL	131_35.pdf
著者	村上敬祥 \| 藤本善三\| 村嶋信尚 \| 仁科拓也\| 杉生久実 \| 松本剛昌\|
抄録	A 78-year-old Japanese woman was referred to our hospital because of fecal occult blood. Barium enema and CT colonography revealed the herniation of the transverse colon and the greater omentum into the right hemithorax through a retrosternal defect. We diagnosed a Morgagni hernia, and we performed a laparoscopic hernia repair with a three-port approach. The invaginated transverse colon and omentum were easily reduced into the abdominal cavity. The size of the hernial orifice was estimated to be approx. 2.5×4 cm. We placed Ventralight ST® mesh over the hernial orifice without hernial sac resection, and we used the double-crown technique to fix the mesh with a hernia stapler. The postoperative course was uneventful, and the patient was discharged on the 5th postoperative day with no complications. There has been no recurrence at 2 years after the surgery. Laparoscopic repair is a safe, less-invasive and useful method for repairing a Morgagni hernia.
キーワード	Morgagni 孔ヘルニア (Morgagni hernia) 胸骨後ヘルニア (retrosternal hernia) 腹腔鏡下手術 (laparoscopic repair) Ventralight ST®
出版物タイトル	岡山医学会雑誌
発行日	2019-04-01
巻	131巻
号	1号
開始ページ	35
終了ページ	39
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.131.35
言語	日本語
著作権者	Copyright (c) 2019 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.131.35
NAID	130007642656

A Case of Primary Colonic Signet Ring Cell Carcinoma in a Young Man which Preoperatively Mimicked Phlebosclerotic Colitis

JaLCDOI	10.18926/AMO/56939
フルテキストURL	73_4_361.pdf
著者	Watanabe, Ayako\| Kadowaki, Yoshihiko\| Hattori, Kenji\| Ohmori, Mika\| Tsukayama, Hiroyuki\| Kubota, Nobuhito\| Okumoto, Tatsuo\| Ishido, Nobuhiro\| Okino, Takeshi\|
抄録	A 35-year-old man was referred to our hospital for chronic abdominal pain and diarrhea. Computed tomography showed wall thickening, poor contrast enhancement and calcification of the ascending colon, which were consistent with phlebosclerotic colitis. Malignant character was not detected from a biopsy specimen. Operatively, we observed a scirrhous mass of the ascending colon invading surrounding tissue, which was diagnosed as signet ring cell carcinoma based on analysis of an intraoperative frozen section. Right hemicolectomy with regional lymph node dissection was performed. This case was extremely similar to phlebosclerotic colitis in clinical findings; surgical resection was required for correct diagnosis.
キーワード	phlebosclerotic colitis colorectal cancer signet ring cell carcinoma young colorectal cancer
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2019-08
巻	73巻
号	4号
出版者	Okayama University Medical School
開始ページ	361
終了ページ	365
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31439960

Significance of Microcalcifications on Mammography in the Surgical Treatment of Breast Cancer Patients with a Preoperative Diagnosis of Ductal Carcinoma in Situ by Core Needle Biopsy

JaLCDOI	10.18926/AMO/56937
フルテキストURL	73_4_349.pdf
著者	Isozaki, Hiroshi\| Yamamoto, Yasuhisa\| Murakami, Shigeki\| Matsumoto, Sasau\| Takama, Takehiro\|
抄録	To clarify the surgical outcomes of breast cancer patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) by core needle biopsy (CNB) (abbreviated as CNBDCIS), we retrospectively analyzed the cases of 131 patients with CNBDCIS who underwent surgery at Oomoto Hospital (32 total mastectomies, 99 conservative mastectomies). Our analysis of underestimation and predictors of invasive breast cancer of CNBDCIS revealed that the underestimation rate of CNBDCIS was 40.5% (53/131). A logistic regression analysis revealed that palpable tumors (yes to no, odds ratio [OR] 3.25), mammography (MMG) category group (category 4 or 5 to categories 1 , 2, or 3, OR 4.69) and MMG microcalcifications (no to yes, OR 0.24) were significant predictive factors for CNBDCIS invasion. In our analysis of the predictors of positive margins during CNBDCIS surgery, 36 (27.5%) of the 131 patients had positive margins after postoperative pathological examination. A logistic regression analysis revealed that the operative procedure (conservative surgery to total mastectomy, OR 21.4) and MMG microcalcifications (yes to no, OR 3.35) were significant factors related to positive margins during CNBDCIS surgery. Thus, MMG microcalcifications are a negative predictor of upgrading of CNBDCIS and a positive predictor of positive surgical margins for CNBDCIS.
キーワード	ductal carcinoma in situ core needle biopsy underestimation positive margins microcalcifications on mammography
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-08
巻	73巻
号	4号
出版者	Okayama University Medical School
開始ページ	349
終了ページ	356
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31439958

Dynamic Reorganization of Microtubule and Glioma Invasion

JaLCDOI	10.18926/AMO/56930
フルテキストURL	73_4_285.pdf
著者	Otani, Yoshihiro\| Ichikawa, Tomotsugu\| Kurozumi, Kazuhiko\| Date, Isao\|
抄録	Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion.
キーワード	glioma cytoskeletons invasion microtubules
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2019-08
巻	73巻
号	4号
出版者	Okayama University Medical School
開始ページ	285
終了ページ	297
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31439951

はじめに

フルテキストURL	rpkj_2019_prelim.pdf
著者	中谷文美\| 松本直子\| 光本順\|
出版物タイトル	岡山大学文学部プロジェクト研究「ジェンダーの多層性に関する領域横断的研究」記録集
発行日	2019-03-29
言語	日本語
論文のバージョン	publisher

A reporter system evaluates tumorigenesis, metastasis, β-catenin/MMP regulation, and druggability

フルテキストURL	Tissue_Eng_A_2018_0348.pdf
著者	Sogawa, Chiharu\| Eguchi, Takanori\| Okusha, Yuka\| Ono, Kisho\| Ohyama, Kazumi\| Iizuka, Motoharu\| Kawasaki, Ryu\| Hamada, Yusaku\| Takigawa, Masaharu\| Sogawa, Norio\| Okamoto, Kuniaki\| Kozaki , Ken-ichi\|
キーワード	3D tumoroid reporter assay Wnt/β-catenin signaling cancer metastasis metalloproteinase syngeneic transplantation tumoroid (tumor organoid)
備考	This is an Accepted Manuscript of an article published by Mary Ann Liebert\|
発行日	2019-02-08
出版物タイトル	Tissue Engineering Part A.
巻	25巻
号	19-20号
出版者	Mary Ann Liebert
開始ページ	1413
終了ページ	1425
ISSN	19373341
NCID	AA12306003
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	30734664
DOI	10.1089/ten.TEA.2018.0348
NAID	120006788780
Web of Science KeyUT	000489035900008
関連URL	isVersionOf https://doi.org/10.1089/ten.TEA.2018.0348

ドイツ付近の冬における日々の大きな気温変動に関する総観気候学的解析（冬の追い出しの行事「ファスナハト」における季節感に関連して）

JaLCDOI	10.18926/ESR/56692
タイトル（別表記）	Synoptic climatological analyses on the large day-to-day variation of air temperature around Germany in winter (Relating to the “seasonal feeling” in “Fasnacht”, the festival for driving the winter away)
フルテキストURL	esr_025_007_017.pdf
著者	濱木達也\| 加藤内藏進 \| 大谷和男\| 加藤晴子\| 松本健吾\|
抄録	Synoptic climatological analyses associated with the large day-to-day variation of air temperature around Germany in winter were performed based mainly on the NCEP/NCAR reanalysis data for 2000/2001 to 2010/2011 winters, with an interest in the relationship to the “seasonal feeling” in “Fasnacht”, the festival for driving the winter away. The intermittent appearance of the extremely cold days with rather large day-to-day variation in winter as pointed out by Kato et al. (2017) for around Germany was seen also to the north and to the east of Germany. According to a case study for the 2000/2001 winter, such large daily mean temperature fluctuation was closely related to the intraseasonal variation of the Icelandic low with about one month period, i.e., while the temperature around Germany was relatively higher at the eastward shift phase of the Icelandic low due to the strong warm air advection by the SW-ly wind, the temperature was extremely low there when the Icelandic low was weakened and retreated westward.
キーワード	Comparative climatology Climate around Europe Synoptic climatology on daily temperature variation in winter around Germany seasonal cycle and “seasonal feeling”
出版物タイトル	Okayama University Earth Science Report
発行日	2018-12-27
巻	25巻
号	1号
開始ページ	7
終了ページ	17
ISSN	1340-7414
言語	日本語
著作権者	© 2018 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved
論文のバージョン	publisher

平成29年度岡山医学会賞がん研究奨励賞（林原賞・山田賞）

タイトル（別表記）	The 2017 Incentive Award of the Okayama Medical Association in Cancer Research (2017 Hayashibara Prize and Yamada Prize)
フルテキストURL	130_117.pdf
著者	大谷理浩\|
出版物タイトル	岡山医学会雑誌
発行日	2018-12-03
巻	130巻
号	3号
開始ページ	117
終了ページ	118
ISSN	0030-1558
関連URL	references https://doi.org/10.1038/onc.2017.373
言語	日本語
著作権者	Copyright (c) 2018 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.130.117
NAID	130007542865

Flap Reconstruction for Esophageal Perforation Following Anterior Cervical Plate Fixation

JaLCDOI	10.18926/AMO/56462
フルテキストURL	73_1_77.pdf
著者	Morita, Mio\| Matsumoto, Hiroshi\| Shirakawa, Yasuhiro\| Noma, Kazuhiro\| Tanabe, Shunsuke\| Kimata, Yoshihiro\|
抄録	Anterior cervical plate fixation is a common surgical treatment for cervical spine trauma, disc herniation, or cervical spondylosis. Esophageal perforation following anterior cervical plate fixation is a rare but serious complication. Management of esophageal perforation is controversial; however, we suggest treating most cases surgically because this condition is slow to heal and often fatal. We managed 2 cases of esophageal perforation following anterior cervical plate fixation by flap reconstruction with the pectoralis major muscle in one case and a jejunal free flap in the other. Here, we report our experience and review the surgical indications.
キーワード	anterior cervical plate fixation esophageal perforation reconstruction pectoralis major flap jejunal free flap
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2019-02
巻	73巻
号	1号
出版者	Okayama University Medical School
開始ページ	77
終了ページ	80
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30820058

Histidine-rich Glycoprotein Could Be an Early Predictor of Vasospasm after Aneurysmal Subarachnoid Hemorrhage

JaLCDOI	10.18926/AMO/56456
フルテキストURL	73_1_29.pdf
著者	Matsumoto, Atsushi\| Nakamura, Takehiro\| Shinomiya, Aya\| Kawakita, Kenya\| Kawanishi, Masahiko\| Miyake, Keisuke\| Kuroda, Yasuhiro\| Keep, Richard F.\| Tamiya, Takashi\|
抄録	Cerebral vasospasm (CVS) is a major contributor to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. We measured histidine-rich glycoprotein (HRG), a new biomarker of aSAH, in cerebrospinal fluid (CSF) to investigate whether HRG might be an early predictor of CVS. A total of seven controls and 14 aSAH patients (8 males, 6 females aged 53.4±15.4 years) were enrolled, and serial CSF and serum samples were taken. We allocated these samples to three phases (T1-T3) and measured HRG, interleukin (IL)-6, fibrinopeptide A (FpA), and 8-hydroxy-2’-deoxyguanosine (8OHdG) in the CSF, and the HRG in serum. We also examined the release of HRG in rat blood incubated in artificial CSF. In contrast to the other biomarkers examined, the change in the CSF HRG concentration was significantly different between the nonspasm and spasm groups (p<0.01). The rat blood/CSF model revealed a time course similar to that of the human CSF samples in the non-spasm group. HRG thus appears to have the potential to become an early predictor of CVS. In addition, the interaction of HRG with IL-6, FpA, and 8OHdG may form the pathology of CVS.
キーワード	biomarker histidine-rich glycoprotein predictor subarachnoid hemorrhage vasospasm
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-02
巻	73巻
号	1号
出版者	Okayama University Medical School
開始ページ	29
終了ページ	39
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30820052

Reduction of Postoperative Pain by Addition of Intravenous Acetaminophen after Total Hip Arthroplasty: A Retrospective Cohort Study

JaLCDOI	10.18926/AMO/56453
フルテキストURL	73_1_7.pdf
著者	Fukumori, Norio\| Sonohata, Motoki\| Kitajima, Masaru\| Kawano, Shunsuke\| Kurata, Tsuyoshi\| Sakanishi, Yuta\| Sugioka, Takashi\| Mawatari, Masaaki\|
抄録	We evaluated the analgesic effects of multimodal pain control in which intravenous acetaminophen (IV APAP) was added to the standard protocol for Japanese patients who had undergone a total hip arthroplasty (THA). We performed a retrospective cohort study of 180 patients aged 66.4±10.5 years (30% male) who had undergone a THA (Oct. 2014 to Feb. 2015) at our hospital. The control patients were administered the standard analgesic protocol: flurbiprofen axetil as a continuous intravenous infusion and oral celecoxib (NAPAP; n=109). The patients in the new analgesic protocol group received IV APAP in addition to the standard analgesic protocol (APAP; n=71). The primary outcome was the maximum value of postoperative pain the patients reported on a numerical rating scale (NRS) during the first 24 h post-surgery. A univariate analysis and multivariate analyses adjusted for age, sex, the stage of hip osteoarthritis, preoperative pain, and surgical time showed that the maximum postoperative pain NRS scores during the first 24 h after surgery was significantly lower when the APAP protocol was used. The addition of IV APAP to the current standard multimodal analgesia protocol for Japanese patients who have undergone a THA may decrease the patients’ postoperative pain.
キーワード	intravenous acetaminophen postoperative pain total hip arthroplasty osteoarthritis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-02
巻	73巻
号	1号
出版者	Okayama University Medical School
開始ページ	7
終了ページ	14
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30820049