検索結果 - 岡山大学学術成果リポジトリ

The molecular mechanism of photochemical internalization of cell penetrating peptide-cargo-photosensitizer conjugates.

著者	Ohtsuki, Takashi\| Miki, Shunya\| Kobayashi, Shouhei\| Haraguchi, Tokuko\| Nakata, Eiji\| Hirakawa, Kazutaka\| Sumita, Kensuke\| Watanabe, Kazunori\| Okazaki, Shigetoshi\|
発行日	2015-12
出版物タイトル	Scientific Reports
巻	5巻
資料タイプ	学術雑誌論文

The First Chemical Synthesis of 6-Thio-D-fructopyranose via Methyl 6-Bromo-6-deoxy-1,3-O-isopropylidene-α-D-fructofuranoside as a Key Intermediate

著者	花谷正\| Sato, Nobuaki\| Yamamoto, Hiroshi\|
発行日	2007-04
出版物タイトル	Heterocycles
巻	71巻
号	3号
資料タイプ	学術雑誌論文

Chelate titrations of Ca2+ and Mg2+ using microfluidic paper-based analytical devices

フルテキストURL	ACA_924_60.pdf
著者	Karita, Shingo\| Kaneta, Takashi\|
キーワード	Chelate titration Microfluidic paper-based analytical device Hardness Calcium Magnesium Natural water
備考	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/\|
発行日	2016-06-14
出版物タイトル	Analytica Chimica Acta
巻	924巻
出版者	Elsevier B.V.
開始ページ	60
終了ページ	67
ISSN	0003-2670
NCID	AA00524834
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2016 Elsevier B.V.
論文のバージョン	author
PubMed ID	27181645
DOI	10.1016/j.aca.2016.04.019
Web of Science KeyUT	000375747700008
関連URL	isVersionOf https://doi.org/10.1016/j.aca.2016.04.019

Direct determination of lignin peroxidase released from Phanerochaete chrysosporium by in-capillary enzyme assay using micellar electrokinetic chromatography

フルテキストURL	JCA_1440_145.pdf
著者	Harada, Airi\| Sasaki, Keiko\| Kaneta, Takashi\|
キーワード	Lignin Peroxidase Phanerochaete chrysosporium Micellar electrokinetic chromatography Capillary electrophoresis Enzyme assay
備考	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/\|
発行日	2016-04-01
出版物タイトル	Journal of Chromatography A
巻	1440巻
出版者	Elsevier Science B.V.
開始ページ	145
終了ページ	149
ISSN	0021-9673
NCID	AA10985833
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	http://creativecommons.org/licenses/by-nc-nd/4.0/
論文のバージョン	author
PubMed ID	26948760
DOI	10.1016/j.chroma.2016.02.062
Web of Science KeyUT	000372943400016
関連URL	isVersionOf https://doi.org/10.1016/j.chroma.2016.02.062

Chemical control of xylem differentiation by thermospermine, xylemin and auxin

フルテキストURL	fulltext.pdf
著者	Yoshimoto, Kaori\| Takamura, Hiroyoshi\| Kadota, Isao\| Motose, Hiroyasu\| Takahashi, Taku\|
発行日	2016-02-16
出版物タイトル	Scientific Reports
巻	6巻
出版者	Nature Publishing
開始ページ	21487
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	publisher
PubMed ID	26879262
DOI	10.1038/srep21487
Web of Science KeyUT	000370228500001
関連URL	isVersionOf https://doi.org/10.1038/srep21487

Chemical control of xylem differentiation by thermospermine, xylemin, and auxin

著者	Yoshimoto, Kaori\| Takamura, Hiroyoshi\| Kadota, Isao\| Motose, Hiroyasu\| Takahashi, Taku\|
発行日	2016-02-16
出版物タイトル	Scientific Reports
巻	6巻
資料タイプ	学術雑誌論文

The Function of β2-glycoprotein I in Angiogenesis and Its in Vivo Distribution in Tumor Xenografts

JaLCDOI	10.18926/AMO/53999
フルテキストURL	70_1_13.pdf
著者	Arum Tri Wahyuningsih\| Shen, Lianhua\| Kobayashi, Kazuko\| Sasaki, Takanori\| Takenaka, Fumiaki\| Hanada, Takahisa\| Akehi, Masaru\| Akahoshi, Akiya\| Ozeki, Eiichi\| Ando, Eiji\| Matsuura, Eiji\|
抄録	Intact β2-glycoprotein I (iβ2GPI) is a glycoprotein that regulates coagulation and fibrinolysis. Nicked β2GPI (nβ2GPI) possesses an angiogenic property at a relatively low concentration, and an antiangiogenic property at a high concentration. Here we investigated the functions of βi 2GPI and nβ2GPI in vascular endothelial growth factor (VEGF)-A-induced endothelial cell proliferation and tube formation. We used noninvasive PET imaging to analyze the in vivo distribution of intravenously injected β2GPI variants in tumor lesions in mice. iβ2GPI was incubated with plasmin to obtain nβ2GPI, and its N-terminal sequence was analyzed. nβ2GPI had at least one other cleavage site upstream of the β2GPIʼs domain V, whereas the former plasmin-cleavage site locates between K317 and T318. Both of intact and nicked β2GPI significantly inhibited the VEGF-A-induced cell proliferation and the tube formation of human umbilical vein endothelial cells (HUVECs). PET imaging visualized considerably distributed intensities of all tested β2GPI variants in tumor lesions of pancreatic tumor cell-xenografts. These results indicate that β2GPI may be physiologically and pathophysiologically important in the regulation of not only coagulation and fibrinolysis, but also angiogenesis.
キーワード	β2-glycoprotein I (β2GPI) angiogenesis vascular endothelial growth factor-A (VEGF-A) positron emission tomography (PET) imaging
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2016-02
巻	70巻
号	1号
出版者	Okayama University Medical School
開始ページ	13
終了ページ	24
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26899605
Web of Science KeyUT	000371288700002

Chiral Ordering in Supercooled Liquid Water and Amorphous Ice

著者	Matsumoto, Masakazu\| Yagasaki, Takuma\| Tanaka, Hideki\|
発行日	2015-11-06
出版物タイトル	Physical Review Letters
巻	115巻
号	19号
資料タイプ	学術雑誌論文

Adsorption and removal of strontium in aqueous solution by synthetic hydroxyapatite

著者	Nishiyama, Yuichi\| Hanafusa, Tadashi\| Yamashita, Jun\| Yamamoto, Yoko\| Ono, Toshiro\|
発行日	2015-06-20
出版物タイトル	Journal of Radioanalytical and Nuclear Chemistry
資料タイプ	学術雑誌論文

Solid-liquid critical behavior of water in nanopores

著者	望月建爾\| 甲賀研一郎\|
発行日	2015-07-07
出版物タイトル	Proceedings of the National Academy of Sciences of the United States of America
巻	112巻
号	27号
資料タイプ	学術雑誌論文

New Limonoids from the Seeds of Xylocarpus granatum

著者	Wu, Yi-Bing\| Liu, Dan\| Liu, Pei-Yu\| Yang, Xue-Mei\| Liao, Man\| Lu, Nan-Nan\| Sauriol, FranÅoise\| Gu, Yu-Cheng\| Shi, Qing-Wen\| Kiyota, Hiromasa\| Dong, Mei\|
発行日	2015-05-26
出版物タイトル	Helvetica Chimica Acta
巻	98巻
号	5号
資料タイプ	学術雑誌論文

Eosinophil Cationic Protein Shows Survival Effect on H9c2 Cardiac Myoblast Cells with Enhanced Phosphorylation of ERK and Akt/GSK-3β under Oxidative Stress

JaLCDOI	10.18926/AMO/53521
フルテキストURL	69_3_145.pdf
著者	Ishii, Hiroko\| Kamikawa, Shigeshi\| Hirohata, Satoshi\| Mizutani, Akifumi\| Abe, Koji\| Seno, Masaharu\| Oohashi, Toshitaka\| Ninomiya, Yoshifumi\|
抄録	Eosinophil cationic protein (ECP) is well known as a cationic protein contained in the basic granules of activated eosinophils. Recent studies have reported that ECP exhibits novel activities on various types of cells, including rat neonatal cardiomyocytes. Here we evaluated the effects of ECP on rat cardiac myoblast H9c2 cells. Our results showed that ECP enhanced the survival of the cells, in part by promoting the ERK and Akt/GSK-3β signaling pathways. ECP attenuated the cytotoxic effects of H2O2 on H9c2 cells as well as the production of reactive oxygen species, the number of apoptotic cells and caspase 3/7 activity in the cells. In conclusion, ECP activated the ERK and Akt/GSK-3β pathways, resulting in anti-oxidative effects on H9c2 cells that attenuated apoptosis.
キーワード	ECP reactive oxygen species Akt ERK
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2015-06
巻	69巻
号	3号
出版者	Okayama University Medical School
開始ページ	145
終了ページ	153
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26101190
Web of Science KeyUT	000356903000003

Selective Preparation of 6- and 7-(Polyhydroxypropyl)pterins from Pentos-2-uloses

著者	花谷正\| Ito, Kasumi\|
発行日	2014-04
出版物タイトル	Heterocycles
巻	88巻
号	2号
資料タイプ	学術雑誌論文

Coordination Chemistry of Ruthenium Complexes with Quinoline-2-carbaldehyde (Pyridine-2-carbonyl)hydrazone

著者	森麻美\|
発行日	2015-03-25
出版物タイトル
資料タイプ	学位論文

長波長紫外線（UVA）によるDNA傷害と突然変異誘発機構の研究

フルテキストURL	K0005137_abstract_review.pdf K0005137_fulltext.pdf
著者	樊星\|
発行日	2015-03-25
資料タイプ	学位論文
学位授与番号	甲第5137号
学位授与年月日	2015-03-25
学位・専攻分野	博士（薬学）
授与大学	岡山大学
言語	日本語

In situ7Li nuclear magnetic resonance study of the relaxation effect in practical lithium ion batteries

著者	Gotoh, Kazuma\| Izuka, Misato\| Arai, Juichi\| Okada, Yumika\| Sugiyama, Teruyasu\| Takeda, Kazuyuki\| Ishida, Hiroyuki\|
発行日	2014-11
出版物タイトル	Carbon
巻	79巻
資料タイプ	学術雑誌論文

Speciation of arsenic in a thermoacidophilic iron-oxidizing archaeon, Acidianus brierleyi, and its culture medium by inductively coupled plasma–optical emission spectroscopy combined with flow injection pretreatment using an anion-exchange mini-column

フルテキストURL	Talanta_122_240–245.pdf
著者	Higashidani, Naoki\| Kaneta, Takashi\| Takeyasu, Nobuyuki\| Motomizu, Shoji\| Okibe, Naoko\| Sasaki, Keiko\|
キーワード	Thermoacidophilic iron-oxidizing archaeon Acidianus brierleyi Arsenic Speciation Inductively coupled plasma–optical emission spectroscopy Flow injection pretreatment
発行日	2014-05
出版物タイトル	Talanta
巻	122巻
出版者	Elsevier
開始ページ	240
終了ページ	245
ISSN	00399140
NCID	AA00856594
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2014 Elsevier B.V. All rights reserved
論文のバージョン	author
PubMed ID	24720990
DOI	10.1016/j.talanta.2014.01.057
Web of Science KeyUT	000335636700037
関連URL	isVersionOf https://doi.org/10.1016/j.talanta.2014.01.057

Molecular Simulation Analysis of the Structure Complex of C2 Domains of DKK Family Members and β-propeller Domains of LRP5/6:Explaining Why DKK3 Does Not Bind to LRP5/6

JaLCDOI	10.18926/AMO/52403
フルテキストURL	68_2_63.pdf
著者	Fujii, Yasuyuki\| Hoshino, Tyuji\| Kumon, Hiromi\|
抄録	Dickkopf (DKK) proteins interact with low-density lipoprotein receptor-related protein 5/6 (LRP5/6) to modulate WNT signaling. The interaction is mediated by a cysteine-rich domain (C2) in the DKK protein and β-propeller domains (PD) of LRP5/6. However, the third member of the DKK family (DKK3) does not bind to LRP5/6. To determine why DKK3 does not bind to the receptor domains, we performed a molecular modeling simulation study including homology modeling, protein-protein docking and molecular dynamics (MD). The computed affinities (ΔGbinding) between the C2 and PD models were consistent with the previously reported experimental results. The C2 model of DKK3 showed the lowest affinity for PD models. Multiple sequence alignment of C2 domains revealed that the DKK3 genes have a unique 7-amino-acid insertion (L249-E255 in human DKK3) and P258 in a finger loop 1 (FL1). Interestingly, the insertion sequence is evolutionally conserved. MD simulations of high-affinity complex models of C2 and PD showed that FL1 directly interacts with the PD models and stabilizes the complex models. We also built a 7-amino-acid-deletion/P258G mutant model of DKK3C2 and estimated its affinities for the PD models. The affinity for human LRP5PD2 was increased by the substitution (ΔGbinding＝－48.9kcal/mol) and the affinity was compatible with that of high-affinity ligands. The results suggested that the lack of affinity between human DKK3 and human LRP5/6 results from: i) insertion of the 7 amino acids, and ii) P258 in human DKK3. The sequence differences thus suggest an explanation for this unique property of DKK3.
キーワード	DKK3 molecular modeling protein-protein docking LRP5/6
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-04
巻	68巻
号	2号
出版者	Okayama University Medical School
開始ページ	63
終了ページ	78
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	24743782
Web of Science KeyUT	000334652700002

Improved syntheses of D-ribo- and 2-deoxy-D-ribofuranose phospho sugars from methyl β-D-ribopyranoside

著者	Hanaya, Tadashi\| Koga, Yuko\| Kawamoto, Heizan\| Yamamoto, Hiroshi\|
発行日	2007-12
出版物タイトル	Heterocycles
巻	73巻
号	1号
資料タイプ	学術雑誌論文

A New Route for Preparation of 2-Deoxy-D-ribofuranose Phospho Sugar

著者	Hanaya, Tadashi\| Tsukui, Hiroyuki\| Igi, Naomi\| Noguchi, Ayashi\| Kawamoto, Heizan\| Yamamoto, Hiroshi\|
発行日	2007-04-13
出版物タイトル	Heterocycles
巻	72巻
号	1号
資料タイプ	学術雑誌論文