検索結果 - 岡山大学学術成果リポジトリ

Metformin-ROS-Nrf2 connection in the host defense mechanism against oxidative stress, apoptosis, cancers, and ageing

フルテキストURL	fulltext20220630-1.pdf
著者	Udono, Heiichiro\| Nishida, Mikako\|
キーワード	Mitochondrial ROS Oxidative stress Apoptosis Ageing Nrf2
備考	© 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.bbagen.2022.130171] . This fulltext is available in Aug. 2023.\|
発行日	2022-08
出版物タイトル	Biochimica et Biophysica Acta (BBA) - General Subjects
巻	1866巻
号	8号
出版者	Elsevier BV
開始ページ	130171
ISSN	0304-4165
NCID	AA00564679
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Elsevier B.V.
論文のバージョン	author
PubMed ID	35588955
DOI	10.1016/j.bbagen.2022.130171
Web of Science KeyUT	000806942900004
関連URL	isVersionOf https://doi.org/10.1016/j.bbagen.2022.130171

A variety of ‘exhausted’ T cells in the tumor microenvironment

フルテキストURL	fulltext20220630-7.pdf figure20220630-7.pdf
著者	Nagasaki, Joji\| Togashi, Yosuke\|
キーワード	CD4(+) T cell cytotoxic CD4(+ )T cell regulatory T cell T-cell exhaustion
備考	This is a pre-copyedited, author-produced version of an article accepted for publication in [International Immunology] following peer review. The version of record [Joji Nagasaki, Yosuke Togashi, A variety of ‘exhausted’ T cells in the tumor microenvironment, International Immunology, Volume 34, Issue 11, November 2022, Pages 563–570, https://doi.org/10.1093/intimm/dxac013] is available online at: [https://doi.org/10.1093/intimm/dxac013] This fulltext is available in April 2023.\|
発行日	2022-4-23
出版物タイトル	International Immunology
巻	34巻
号	11号
出版者	Oxford University Press
開始ページ	563
終了ページ	570
ISSN	1460-2377
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022.
論文のバージョン	author
PubMed ID	35460561
DOI	10.1093/intimm/dxac013
Web of Science KeyUT	000805278200001
関連URL	isVersionOf https://doi.org/10.1093/intimm/dxac013

SMC Development Guidelines for Axial Flux PM Machines Employing Coreless Rotor Structure for Enhancing Efficiency Based on Experimental Results

フルテキストURL	fulltext20220630-6.pdf
著者	Tsunata, Ren\| Takemoto, Masatsugu\| Ogasawara, Satoshi\| Saito, Tatsuya\| Ueno, Tomoyuki\|
備考	© 2022 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. \|
発行日	2022-5
出版物タイトル	IEEE Transactions on Industry Applications
巻	58巻
号	3号
出版者	Institute of Electrical and Electronics Engineers (IEEE)
開始ページ	3470
終了ページ	3485
ISSN	0093-9994
NCID	AA00667900
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	Copyright © 2022, IEEE
論文のバージョン	author
DOI	10.1109/tia.2022.3154336
Web of Science KeyUT	000799279300052
関連URL	isVersionOf https://doi.org/10.1109/tia.2022.3154336

Medial meniscus posterior root repair influences sagittal length and coronal inclination of the anterior cruciate ligament: a retrospective study

フルテキストURL	fulltext20220630-5.pdf figure20220630-5.pdf
著者	Okazaki, Yuki\| Furumatsu, Takayuki\| Kodama, Yuya\| Hiranaka, Takaaki\| Kintaka, Keisuke\| Kamatsuki, Yusuke\| Ozaki, Toshifumi\|
キーワード	Anterior cruciate ligament Coronal inclination Knee kinematics Magnetic resonance imaging Medial meniscus Posterior root tear
備考	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00590-022-03285-0 This fulltext is available in May 2023.\|
発行日	2022-05-20
出版物タイトル	European Journal of Orthopaedic Surgery and Traumatology
巻	33巻
号	4号
出版者	Springer Science and Business Media LLC
開始ページ	1255
終了ページ	1262
ISSN	1432-1068
NCID	AA11622799
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature 2022
論文のバージョン	author
PubMed ID	35593940
DOI	10.1007/s00590-022-03285-0
Web of Science KeyUT	000800795900002
関連URL	isVersionOf https://doi.org/10.1007/s00590-022-03285-0

Role of Oxygen Vacancy in the Photocarrier Dynamics of WO3 Photocatalysts: The Case of Recombination Centers

フルテキストURL	fulltext20220630-4.pdf
著者	Kato, Kosaku\| Uemura, Yohei\| Asakura, Kiyotaka\| Yamakata, Akira\|
備考	This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Physical Chemistry C, copyright © 2022 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jpcc.2c01662 This fulltext is available in May 2023.\|
発行日	2022-05-25
出版物タイトル	The Journal of Physical Chemistry C
巻	126巻
号	22号
出版者	American Chemical Society
開始ページ	9257
終了ページ	9263
ISSN	1932-7447
NCID	AA1217589X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 American Chemical Society
論文のバージョン	author
DOI	10.1021/acs.jpcc.2c01662
Web of Science KeyUT	000810253900001
関連URL	isVersionOf https://doi.org/10.1021/acs.jpcc.2c01662

Design and Synthesis of Glycosylated Cholera Toxin B Subunit as a Tracer of Glycoprotein Trafficking in Organelles of Living Cells

フルテキストURL	fulltext20220630-3.pdf
著者	Maki, Yuta\| Kawata, Kazuki\| Liu, Yanbo\| Goo, Kang‐Ying\| Okamoto, Ryo\| Kajihara, Yasuhiro\| Satoh, Ayano\|
キーワード	glycoprotein N-glycan cholera toxin native chemical ligation live imaging
備考	This is the peer reviewed version of the following article: [Y. Maki, K. Kawata, Y. Liu, K.-Y. Goo, R. Okamoto, Y. Kajihara, A. Satoh, Chem. Eur. J. 2022, 28, e202201253], which has been published in final form at [https://doi.org/10.1002/chem.202201253]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. This fulltext is available in May 2023.\|
発行日	2022-05-23
出版物タイトル	Chemistry - A European Journal
巻	28巻
号	37号
出版者	Wiley
開始ページ	e202201253
ISSN	0947-6539
NCID	AA11076269
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Wiley-VCH GmbH
論文のバージョン	author
PubMed ID	35604098
DOI	10.1002/chem.202201253
Web of Science KeyUT	000798823300001
関連URL	isVersionOf https://doi.org/10.1002/chem.202201253

N-Benzoyl leucomethylene blue as a novel substrate for the assays of horseradish peroxidase by spectrophotometry and capillary electrophoresis–laser-induced fluorometry

フルテキストURL	fulltext20220620-4.pdf
著者	Ren, Jianchao\| Kaneta, Takashi\|
備考	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s44211-022-00078-7 This fulltext is available in Feb. 2023.\|
発行日	2022-02-25
出版物タイトル	Analytical Sciences
巻	38巻
号	4号
出版者	Springer Science and Business Media LLC
開始ページ	651
終了ページ	655
ISSN	0910-6340
NCID	AA10500785
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022. The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry.
論文のバージョン	author
PubMed ID	35286641
DOI	10.1007/s44211-022-00078-7
Web of Science KeyUT	000808551700004
関連URL	isVersionOf https://doi.org/10.1007/s44211-022-00078-7

Persistent methicillin-resistant Staphylococcus aureus bacteremia in an adult patient with Netherton's syndrome: A case report

フルテキストURL	fulltext20220630-2.pdf
著者	Takahashi, Misa\| Hagiya, Hideharu\| Tanaka, Shuichi\| Yamamoto, Koichiro\| Honda, Hiroyuki\| Hasegawa, Kou\| Otsuka, Fumio\|
備考	© 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.02.021] . This fulltext is available in March 2023.\|
発行日	2022-7
出版物タイトル	Journal of Infection and Chemotherapy
巻	28巻
号	7号
出版者	Elsevier BV
開始ページ	978
終了ページ	981
ISSN	1341-321X
NCID	AA11057978
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Elsevier B.V.
論文のバージョン	author
PubMed ID	35277342
DOI	10.1016/j.jiac.2022.02.021
Web of Science KeyUT	000808081000003
関連URL	isVersionOf https://doi.org/10.1016/j.jiac.2022.02.021

Eco-Benign Orange-Hued Pigment Derived from Aluminum-Enriched Biogenous Iron Oxide Sheaths

フルテキストURL	fulltext.pdf
著者	Tamura, Katsunori\| Oshima, Yuri\| Fuse, Yuta\| Nagaoka, Noriyuki\| Kunoh, Tatsuki\| Nakanishi, Makoto\| Fujii, Tatsuo\| Nanba, Tokuro\| Takada, Jun\|
発行日	2022-04-10
出版物タイトル	ACS Omega
巻	7巻
号	15号
出版者	American Chemical Society
開始ページ	12795
終了ページ	12802
ISSN	2470-1343
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Authors.
論文のバージョン	publisher
PubMed ID	35474768
DOI	10.1021/acsomega.1c07390
Web of Science KeyUT	000812569200001
関連URL	isVersionOf https://doi.org/10.1021/acsomega.1c07390

Patients' acceptability and implementation outcomes of a case management approach to encourage participation in colorectal cancer screening for people with schizophrenia: a qualitative secondary analysis of a mixed-method randomised clinical trial

フルテキストURL	fulltext.pdf
著者	Yamada, Yuto\| Fujiwara, Masaki\| Shimazu, Taichi\| Etoh, Tsuyoshi\| Kodama, Masafumi\| So, Ryuhei\| Matsushita, Takanori\| Yoshimura, Yusaku\| Horii, Shigeo\| Fujimori, Maiko\| Takahashi, Hirokazu\| Nakaya, Naoki\| Miyaji, Tempei\| Hinotsu, Shiro\| Harada, Keita\| Okada, Hiroyuki\| Uchitomi, Yosuke\| Yamada, Norihito\| Inagaki, Masatoshi\|
発行日	2022-06
出版物タイトル	BMJ Open
巻	12巻
号	6号
出版者	BMJ Publishing Group
開始ページ	e060621
ISSN	2044-6055
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Author(s) (or their employer(s)) 2022.
論文のバージョン	publisher
PubMed ID	35701062
DOI	10.1136/bmjopen-2021-060621
Web of Science KeyUT	000811702800009
関連URL	isVersionOf https://doi.org/10.1136/bmjopen-2021-060621

Histone Demethylase Jmjd3 Regulates the Osteogenic Differentiation and Cytokine Expressions of Periodontal Ligament Cells

JaLCDOI	10.18926/AMO/63722
フルテキストURL	76_3_281.pdf
著者	Yu, Bo\| Wang, Rui\| Luo, Huikun\| Yang, Di\| Wang, Simo\| Yu, Yaqiong\| Okamura, Hirohiko\| Qiu, Lihong\|
抄録	Periodontal ligament (PDL) cells are critical for the bone remodeling process in periapical lesions since they can differentiate into osteoblasts and secrete osteoclastogenesis-promoting cytokines. Post-translational histone modifications including alterations of the methylation status of H3K27 are involved in cell differentiation and inflammatory reaction. The histone demethylase Jumonji domain-containing 3 (Jmjd3) specifically removes methylation of H3K27. We investigated whether Jmjd3 is involved in the osteogenic differentiation and secretion of PDL cells’ inflammatory factors. Jmjd3 expression in periapical lesions was examined by immunostaining. Using siRNA specific for Jmjd3 or the specific Jmjd3 inhibitor GSK-J4, we determined Jmjd3’s roles in osteogenic differentiation and cytokine production by real-time RT-PCR. The locations of Jmjd3 and NF-κB were analyzed by immunocytochemistry. Compared to healthy PDLs, the periapical lesion samples showed higher Jmjd3 expression. Treatment with GSK-J4 or Jmjd3 siRNA suppressed PDL cells’ osteogenic differentiation by suppressing the expressions of bone-related genes (Runx2, Osterix, and osteocalcin) and mineralization. Jmjd3 knockdown decreased the expressions of cytokines (TNF-α, IL-1β, and IL-6) induced by lipopolysaccharide extracted from Porphyromonas endodontalis (Pe-LPS). Pe-LPS induced the nuclear translocations of Jmjd3 and NF-κB; the latter was inhibited by GSK-J4 treatment. Jmjd3 appears to regulate PDL cells’ osteogenic differentiation and proinflammatory cytokine expressions.
キーワード	periapical lesions histone demethylase Jmjd3 periodontal ligament cell osteogenic differentiation proinflammatory cytokines
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-06
巻	76巻
号	3号
出版者	Okayama University Medical School
開始ページ	281
終了ページ	290
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35790358
Web of Science KeyUT	000823568300007

Possibility of Predicting Pelvic Inclination Following Total Hip Arthroplasty Based on the Preoperative State: Sacral Slope and Pelvic Incidence Minus Lumbar Lordosis as Predictive Factors

JaLCDOI	10.18926/AMO/63721
フルテキストURL	76_3_273.pdf
著者	Furuichi, Shuro\| Mitani, Shigeru\| Endo, Hirosuke\| Namba, Yoshifumi\| Kawamoto, Toyohiro\|
抄録	Following total hip arthroplasty (THA), some patients exhibit anterior or posterior pelvic tilt (PT). This case– control study investigated whether changes to PT following THA can be preoperatively predicted. Methods: 135 patients with hip osteoarthritis who underwent THA were assessed. The parameters measured preoperatively and one year postoperatively were lumbar lordosis (LL) based on plain X-ray and pelvic incidence (PI), PT, and sacral slope (SS), all of which were measured as pelvic morphological angles. Patients were classified into groups (A–E) based on the degree of post-THA PT, and their preoperative conditions were compared. PI minus LL was used to evaluate spinal alignment and pelvic balance. Results: Overall, 33%, 30%, 21%, 13%, and 3% of the hips of patients in Groups A, B, C, D, and E were postoperatively assessed. In Groups A–E, the SS values were 34.6°±8.9°, 37.6°±8.4°, 37.9°±8.9°, 42.6°±9.5°, and 60.0°±11.1°, whereas the PI minus LL values were 2.9°±15.0°, 1.2°±13.6°, 3.6°±17.7°, 12.7°±13.1°, and −1.3°±11.7°, respectively. Conclusions: Following THA, 70% of patients experienced posterior PT. Pre-THA SS ≥45° or PI minus LL ≥15° signified marked postoperative posterior tilt and could predict postoperative PT following THA. These findings are useful for implant placement, as they can predict pelvic inclination.
キーワード	hip total hip arthroplasty arthroplasty radiography lordosis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-06
巻	76巻
号	3号
出版者	Okayama University Medical School
開始ページ	273
終了ページ	280
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35790357
Web of Science KeyUT	000823568300006

The Impact of Medical Students Teaching Basic Life Support to Laypersons

JaLCDOI	10.18926/AMO/63720
フルテキストURL	76_3_265.pdf
著者	Kosaki, Yoshinori\| Naito, Hiromichi\| Iida, Atsuyoshi\| Ihoriya, Hiromi\| Nojima, Tsuyoshi\| Yamada, Taihei\| Yamamoto, Hirotsugu\| Nakamura, Shunsuke\| Mandai, Yasuhiro\| Nakao, Atsunori\|
抄録	Basic life support (BLS) courses for laypersons, including cardiopulmonary resuscitation (CPR) training, is known to improve outcomes of out-of-hospital cardiac events. We asked medical students to provide BLS training for laypersons as a part of their emergency medicine education and evaluated the effects of training on the BLS skills of laypersons. We also used a questionnaire to determine whether the medical students who provided the BLS training were themselves more confident and motivated to perform BLS compared to students who did not provide BLS training. The proportions of laypersons who reported confidence in checking for a response, performing chest compressions, and automated external defibrillator (AED) use were significantly increased after the BLS training. The proportions of medical students who reported increased confidence/motivation in terms of understanding BLS, checking for a response, chest compression, use of AED, and willingness to perform BLS were significantly greater among medical students who provided BLS instructions compared to those who did not. BLS instruction by medical students was associated with an improvement in laypersons’ CPR accuracy and confidence in responding to cardiac arrest. The results indicate that medical students could gain understanding, confidence, and motivation in regard to their BLS skills by teaching BLS to laypersons.
キーワード	BLS medical education emergency medicine resuscitation
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-06
巻	76巻
号	3号
出版者	Okayama University Medical School
開始ページ	265
終了ページ	271
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35790356
Web of Science KeyUT	000823568300005

Intrathecal Administration of the α1 Adrenergic Antagonist Phentolamine Upregulates Spinal GLT-1 and Improves Mirror Image Pain in SNI Model Rats

JaLCDOI	10.18926/AMO/63719
フルテキストURL	76_3_255.pdf
著者	Nakatsuka, Kosuke\| Matsuoka, Yoshikazu\| Kurita, Masako\| Wang, Ruilin\| Tsuboi, Chika\| Sue, Nobutaka\| Kaku, Ryuji\| Morimatsu, Hiroshi\|
抄録	Mirror image pain (MIP) is a type of extraterritorial pain that results in contralateral pain or allodynia. Glutamate transporter-1 (GLT-1) is expressed in astrocytes and plays a role in maintaining low glutamate levels in the synaptic cleft. Previous studies have shown that GLT-1 dysfunction induces neuropathic pain. Our previous study revealed bilateral GLT-1 downregulation in the spinal cord of a spared nerve injury (SNI) rat. We hypothesized that spinal GLT-1 is involved in the mechanism of MIP. We also previously demonstrated noradrenergic GLT-1 regulation. Therefore, this study aimed to investigate the effect of an α1 adrenergic antagonist on the development of MIP. Rats were subjected to SNI. Changes in pain behavior and GLT-1 protein levels in the SNI rat spinal cords were then examined by intrathecal administration of the α1 adrenergic antagonist phentolamine, followed by von Frey test and western blotting. SNI resulted in the development of MIP and bilateral downregulation of GLT-1 protein in the rat spinal cord. Intrathecal phentolamine increased contralateral GLT-1 protein levels and partially ameliorated the 50% paw withdrawal threshold in the contralateral hind paw. Spinal GLT-1 upregulation by intrathecal phentolamine ameliorates MIP. GLT-1 plays a role in the development of MIPs.
キーワード	alpha adrenergic receptor glutamate transporter-1 mirror image pain neuropathic pain spared nerve injury
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-06
巻	76巻
号	3号
出版者	Okayama University Medical School
開始ページ	255
終了ページ	263
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35790355
Web of Science KeyUT	000823568300004

Analysis of Immunity against Measles, Mumps, Rubella, and Varicella Zoster in Adult Recipients of Allogeneic Hematopoietic Stem Cell Transplantation: A Single-Center Experience

JaLCDOI	10.18926/AMO/63718
フルテキストURL	76_3_247.pdf
著者	Yoshida, Shohei\| Fujii, Nobuharu\| Kamoi, Chihiro\| Kitamura, Wataru\| Fujiwara, Hideaki\| Asada, Noboru\| Nishimori, Hisakazu\| Fujii, Keiko\| Matsuoka, Ken-ichi\| Maeda, Yoshinobu\|
抄録	Vaccine-preventable disease (VPD) infections are more severe in immunocompromised hosts. Vaccination against measles, mumps, rubella, and varicella zoster (VZV) (MMRV) is therefore recommended for hematopoietic stem cell transplantation (HCT) recipients. However, studies on adult HCT recipients with VPD infections are limited. At our institution, we have systematically conducted serological MMRV tests as a part of check-up examinations during long-term follow-up (LTFU) after HCT since 2015. This retrospective study aimed to evaluate changes in the serostatus between before and 2 years after allogeneic HCT. Among 161 patients, the pre-transplant seropositivity was 82.7% for measles, 86.8% for mumps, 84.2% for rubella, and 94.3% for VZV. Among 56 patients who underwent LTFU including serological MMRV tests at 2 years after HCT, the percentages maintaining seroprotective antibody levels for measles, mumps, rubella and VZV were 71.5% (40/56), 51.8% (29/56), 48.2% (27/56), and 60.7% (34/56), respectively. Vaccination was recommended for 22 patients, and 12 were vaccinated. Among the 12 vaccinated patients, rates of seroconversion were examined in 2-6 patients for each of the four viruses. They were 100% (3/3) for measles, 33.3% (1/3) for mumps, 50% (3/6) for rubella, and 0% (0/2) for VZV. Further studies are warranted to clarify the effect of vaccination in adult HCT recipients.
キーワード	vaccine-preventable disease vaccination allogeneic hematopoietic stem cell transplantation adult
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-06
巻	76巻
号	3号
出版者	Okayama University Medical School
開始ページ	247
終了ページ	253
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35790354
Web of Science KeyUT	000823568300003

Roles of Transmembrane Protein 97 (TMEM97) in Adipose Tissue and Skeletal Muscle

JaLCDOI	10.18926/AMO/63717
フルテキストURL	76_3_235.pdf
著者	Tenta, Masafumi\| Eguchi, Jun\| Wada, Jun\|
抄録	The combination of sarcopenia and obesity (sarcopenic obesity) is associated with the development of metabolic syndrome and cardiovascular events. The molecular pathways that develop sarcopenic obesity have studied intensively. Transmembrane protein 97 (TMEM97) is 176 amino acids conserved integral membrane protein with four transmembrane domains that is expressed in several types of cancer. Its physiological significance in adipose tissue and skeletal muscle has been unclear. We studied TMEM97-transgenic mice and mice lacking TMEM97, and our findings indicate that TMEM97 expression is regulated in adipose tissue and skeletal muscle from obesity. TMEM97 represses adipogenesis and promotes myogenesis in vitro. Fat-specific TMEM97 transgenic mice showed systemic insulin resistance. Mice overexpressing TMEM97 in skeletal muscle exhibited systemic insulin resistance. Mice lacking TMEM97 were protected against diet-induced obesity and insulin resistance. These phenotypes are associated with the effects of TMEM97 on inflammation genes in adipose tissue and skeletal muscle. Our findings indicates that there is a link between TMEM97 and chronic inflammation in obesity.
キーワード	adipose tissue skeletal muscle obesity
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-06
巻	76巻
号	3号
出版者	Okayama University Medical School
開始ページ	235
終了ページ	245
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35790353
Web of Science KeyUT	000823568300002

響きあう声 : オーラル・ヒストリーの可能性 : 「事実」確定と歴史文書 : タイメン鉄道におけるコレラ患者‘射殺’事件を例証に

フルテキストURL	fulltext20220623-5.pdf
著者	中尾知代\|
備考	小特集「方法としての『オーラル・ヒストリー』再考（II）――オーラル・ヒストリーの実践」\|
出版物タイトル	歴史学研究
巻	813巻
出版者	歴史学研究会
開始ページ	17
終了ページ	29
ISSN	0386-9237
NCID	AN00299161
資料タイプ	学術雑誌論文
言語	日本語
OAI-PMH Set	岡山大学
著作権者	© Rekishigaku kenkyukai, 2006
論文のバージョン	publisher
オフィシャル URL	http://rekiken.jp/journal/\|

戦争捕虜問題の比較文化的考察：「食」の問題を中心に(下)

フルテキストURL	fulltext20220623-4.pdf
著者	中尾知代\|
備考	著作権者の許諾を得て出版社版を掲載\| (上)第22号(98年冬季)pp.27-35 (中)第23号(99年春季)pp.27-39 (下)第26号(99年冬季)pp.77-84\|
発行日	1999
出版物タイトル	季刊戦争責任研究
号	26号
出版者	日本の戦争責任資料センター
開始ページ	77
終了ページ	84
ISSN	13437348
NCID	AN10431480
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	publisher

戦争捕虜問題の比較文化的考察：「食」の問題を中心に(中)

フルテキストURL	fulltext20220623-3.pdf
著者	中尾知代\|
備考	著作権者の許諾を得て出版社版を掲載\| (上)第22号(98年冬季)pp.27-35 (中)第23号(99年春季)pp.27-39 (下)第26号(99年冬季)pp.77-84\|
発行日	1999
出版物タイトル	季刊戦争責任研究
号	23号
出版者	日本の戦争責任資料センター
開始ページ	27
終了ページ	39
ISSN	13437348
NCID	AN10431480
資料タイプ	学術雑誌論文
言語	日本語
OAI-PMH Set	岡山大学
論文のバージョン	publisher

戦争捕虜問題の比較文化的考察：「食」の問題を中心に(上)

フルテキストURL	fulltext20220623-2.pdf
著者	中尾知代\|
備考	著作権者の許諾を得て出版社版を掲載\| (上)第22号(98年冬季)pp.27-35 (中)第23号(99年春季)pp.27-39 (下)第26号(99年冬季)pp.77-84\|
発行日	1998
出版物タイトル	季刊戦争責任研究
号	22号
出版者	日本の戦争責任資料センター
ISSN	13437348
NCID	AN10431480
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	publisher