start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肝生検によって診断された脂肪性肝疾患における肝臓関連イベント予測の検討 kn-title=Clinical variables predicting liver-related events in steatotic liver disease diagnosed by liver biopsy en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OKUBOShinnosuke en-aut-sei=OKUBO en-aut-mei=Shinnosuke kn-aut-name=大久保進之介 kn-aut-sei=大久保 kn-aut-mei=進之介 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil=岡山大学大学院保健学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=リトルリーグショルダーの診断とスポーツ復帰時期を決定するための新しいストレステスト kn-title=Novel stress tests for diagnosing Little League shoulder, and determining the timing of return to sports en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=UCHINOTakahiko en-aut-sei=UCHINO en-aut-mei=Takahiko kn-aut-name=内野崇彦 kn-aut-sei=内野 kn-aut-mei=崇彦 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=法医診断のための横紋筋におけるミオグロビン染色性に対する固定条件の影響 kn-title=The influence of fixing condition on myoglobin stainability of striated muscle as a tool for forensic diagnosis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KOBAYASHIChie en-aut-sei=KOBAYASHI en-aut-mei=Chie kn-aut-name=小林智瑛 kn-aut-sei=小林 kn-aut-mei=智瑛 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=281 end-page=295 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Development Support a Child with Autism to Acquisition of Intersubjective Communication: Through the Environmental Setting of Play with Shared Positive Emotions kn-title=ASD 児における相互伝達行為の獲得を目指した遊びを中心としたコミュニケーション指導　ポジティブな情動の共有を生み出す遊びの環境設定を通して en-subtitle= kn-subtitle= en-abstract=In this study, a play-based instruction was used to promote the acquisition of intersubjective communication in a special needs school for students with intellectual disabilities. The participant was a first-grade boy with autism. As a result, the boy began to show intersubjective communication and to respond to the teacher's instruction. It was suggested that four aspects of the play environment may have promoted the acquisition of intersubjective communication: 1) attractive toys, 2) play with the teacher through attractive toys, 3) intervention according to the developmental process of the target children's play, and 4) empathic involvement to encourage the affective sharing. kn-abstract=　自閉スペクトラム症児は，相互伝達行為の獲得に遅れがあることが指摘されている。本研究では，自閉スペクトラム症の診断のある知的障害特別支援学校小学部１年生男児を対象に，相互伝達行為の獲得を目指して，遊びを中心とした指導を行った。その結果，対象児の遊びが「感覚運動的遊び」「機能的遊び」から「象徴的遊び」「社会的遊び」へと移行するに伴い，相互伝達行為が見られるようになった。また，教師による働き掛けへの応答も見られるようになり，ポジティブな情動の共有が生み出されやすい遊びの環境設定が，相互伝達行為の獲得において効果的であったことが示唆された。遊び環境については，1）魅力的な玩具，2）魅力的な玩具を介した教師との遊び，3）対象児の遊びの発達段階に応じた介入，4）情動の共有を促す共感的関わりの４点が相互伝達行為の獲得を促した可能性が考えられた。 en-copyright= kn-copyright= en-aut-name=KAKUHARAKeisuke en-aut-sei=KAKUHARA en-aut-mei=Keisuke kn-aut-name=角原佳介 kn-aut-sei=角原 kn-aut-mei=佳介 aut-affil-num=1 ORCID= en-aut-name=BANMarina en-aut-sei=BAN en-aut-mei=Marina kn-aut-name=伴真里奈 kn-aut-sei=伴 kn-aut-mei=真里奈 aut-affil-num=2 ORCID= en-aut-name=TANJITakayuki en-aut-sei=TANJI en-aut-mei=Takayuki kn-aut-name=丹治敬之 kn-aut-sei=丹治 kn-aut-mei=敬之 aut-affil-num=3 ORCID= affil-num=1 en-affil=Tobi Special School kn-affil=岡山県立東備支援学校 affil-num=2 en-affil=Special School Affiliated with the Faculty of Education at Okayama University kn-affil=岡山大学教育学部附属特別支援学校 affil-num=3 en-affil=Institute of Human Sciences, University of Tsukuba kn-affil=筑波大学人間系 en-keyword=自閉スペクトラム症 (a Child with Autism) kn-keyword=自閉スペクトラム症 (a Child with Autism) en-keyword=相互伝達行為 (Intersubjective Communication) kn-keyword=相互伝達行為 (Intersubjective Communication) en-keyword=情動の共有 (effective sharing) kn-keyword=情動の共有 (effective sharing) en-keyword=遊びの環境設定 (Setting of Play) kn-keyword=遊びの環境設定 (Setting of Play) END start-ver=1.4 cd-journal=joma no-vol=136 cd-vols= no-issue=3 article-no= start-page=132 end-page=134 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20241202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ulcerative colitis kn-title=潰瘍性大腸炎 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HiraokaSakiko en-aut-sei=Hiraoka en-aut-mei=Sakiko kn-aut-name=平岡佐規子 kn-aut-sei=平岡 kn-aut-mei=佐規子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Inflammatory Bowel Disease Center, Okayama University Hospital kn-affil=岡山大学病院　炎症性腸疾患センター en-keyword=潰瘍性大腸炎 kn-keyword=潰瘍性大腸炎 en-keyword=炎症性腸疾患 kn-keyword=炎症性腸疾患 en-keyword=診断 kn-keyword=診断 en-keyword=治療 kn-keyword=治療 END start-ver=1.4 cd-journal=joma no-vol=136 cd-vols= no-issue=3 article-no= start-page=127 end-page=131 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20241202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Eosinophilic chronic rhinosinusitis kn-title=好酸球性副鼻腔炎 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MakiharaSeiichiro en-aut-sei=Makihara en-aut-mei=Seiichiro kn-aut-name=牧原靖一郎 kn-aut-sei=牧原 kn-aut-mei=靖一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Otolaryngology-Head & Neck Surgery, Okayama University Hospital kn-affil=岡山大学病院　耳鼻咽喉・頭頸部外科 en-keyword=好酸球性副鼻腔炎 kn-keyword=好酸球性副鼻腔炎 en-keyword=診断基準 kn-keyword=診断基準 en-keyword=治療 kn-keyword=治療 en-keyword=気管支喘息 kn-keyword=気管支喘息 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=診断精度の向上: 頭頚部腫瘍のSimple Diffusion Kurtosis Imagingにおける前処理フィルターの評価 kn-title=Enhancing Diagnostic Precision: Evaluation of Preprocessing Filters in Simple Diffusion Kurtosis Imaging for Head and Neck Tumors en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NAKAMITSUYuki en-aut-sei=NAKAMITSU en-aut-mei=Yuki kn-aut-name=仲光勇輝 kn-aut-sei=仲光 kn-aut-mei=勇輝 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil=岡山大学大学院保健学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=小児白血病における診断期間の遅れと生存アウトカムに関する単施設後方視的研究 kn-title=Delayed diagnostic interval and survival outcomes in pediatric leukemia: A single-center, retrospective study en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TAMEFUSAKosuke en-aut-sei=TAMEFUSA en-aut-mei=Kosuke kn-aut-name=爲房宏輔 kn-aut-sei=爲房 kn-aut-mei=宏輔 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ASL 撮影ができない MRI 装置における再燃時の脳卒中発作を伴う小児 MELAS を対象とした FLAIR 画像を用いた診断の提案 kn-title=Proposal for diagnosis using FLAIR image aimed for pediatric MELAS with recurrent stroke-like episodes on MRI system cannot take ASL imaging. en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SHIMADAMakoto en-aut-sei=SHIMADA en-aut-mei=Makoto kn-aut-name=島田真 kn-aut-sei=島田 kn-aut-mei=真 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil=岡山大学大学院保健学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=口腔顎顔面領域の脈管異常に対する画像診断に基づくアプローチ kn-title=An imaging-based diagnostic approach to vascular anomalies of the oral and maxillofacial region en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Wlla Alhammad en-aut-sei=Wlla Alhammad en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺動脈にいつ介入するべきか。肺動脈縮窄症診断におけるの解剖学的評価の重要性 kn-title=When to intervene the pulmonary artery: Importance of anatomical assessment in the diagnosis of pulmonary artery coarctation en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KISAMORIEiri en-aut-sei=KISAMORI en-aut-mei=Eiri kn-aut-name=木佐森永理 kn-aut-sei=木佐森 kn-aut-mei=永理 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=136 cd-vols= no-issue=1 article-no= start-page=7 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Intraoperative diagnosis of brain tumors using fluorescent probes kn-title=脳腫瘍の術中蛍光診断 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TanakaShota en-aut-sei=Tanaka en-aut-mei=Shota kn-aut-name=田中將太 kn-aut-sei=田中 kn-aut-mei=將太 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Neurological Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences. Okayama University kn-affil=岡山大学学術研究院医歯薬学域　脳神経外科学 en-keyword=膠芽腫 kn-keyword=膠芽腫 en-keyword=外科的摘出 kn-keyword=外科的摘出 en-keyword=蛍光プローブ kn-keyword=蛍光プローブ en-keyword=5-ALA kn-keyword=5-ALA en-keyword=HMRG kn-keyword=HMRG END start-ver=1.4 cd-journal=joma no-vol=185 cd-vols= no-issue= article-no= start-page=123 end-page=132 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240222 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Exploring Conflicts Experienced by Parents of Children Who are Deaf or Hard of Hearing With an Autism Spectrum Disorder Between the First and Second Diagnostic Processes kn-title=聾・難聴児が自閉症診断依頼に至るまでの親の葛藤に関する文献分析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　本稿では，子供が聾・難聴と診断され，その後に自閉症の診断が追加された体験を持つ親を調査対象とした先行研究を分析し，自閉症診断依頼に至るまでの親の葛藤がどのようなものであるかについて，「肯定的矛盾と否定的矛盾の共立」概念を用いて考察した。結果，２つのテーマと７つのサブテーマが「肯定的矛盾」体験を表すものとして抽出されたが，その中に潜在している否定的矛盾を捉えることこそ，診断過程を親と共に歩む教師には必要であることを述べた。 en-copyright= kn-copyright= en-aut-name=OHTAKEYoshihisa en-aut-sei=OHTAKE en-aut-mei=Yoshihisa kn-aut-name=大竹喜久 kn-aut-sei=大竹 kn-aut-mei=喜久 aut-affil-num=1 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=岡山大学学術研究院教育学域 en-keyword=聾・難聴 kn-keyword=聾・難聴 en-keyword=自閉症スペクトラム障害 kn-keyword=自閉症スペクトラム障害 en-keyword=親 kn-keyword=親 en-keyword=診断 kn-keyword=診断 en-keyword=先行研究分析 kn-keyword=先行研究分析 END start-ver=1.4 cd-journal=joma no-vol=135 cd-vols= no-issue=3 article-no= start-page=142 end-page=146 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20231201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Systemic amyloidosis : Diagnosis and treatment of transthyretin cardiac amyloidosis kn-title=全身性アミロイドーシス― トランスサイレチン型心アミロイドーシスの診断と治療― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakamuraKazufumi en-aut-sei=Nakamura en-aut-mei=Kazufumi kn-aut-name=中村一文 kn-aut-sei=中村 kn-aut-mei=一文 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学学術研究院医歯薬学域　循環器内科学 en-keyword=トランスサイレチン kn-keyword=トランスサイレチン en-keyword=免疫グロブリン kn-keyword=免疫グロブリン en-keyword=ピロリン酸シンチグラフィー kn-keyword=ピロリン酸シンチグラフィー en-keyword=タファミジス kn-keyword=タファミジス en-keyword=核酸医薬 kn-keyword=核酸医薬 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=限局性上部尿路上皮癌診断における、tumor grade, tumor stageによる予測モデルの臨床的有用性の検討 kn-title=Accuracy and Clinical Utility of a Tumor Grade- and Stage-based Predictive Model in Localized Upper Tract Urothelial Carcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KATAYAMASatoshi en-aut-sei=KATAYAMA en-aut-mei=Satoshi kn-aut-name=片山聡 kn-aut-sei=片山 kn-aut-mei=聡 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=精神症状を伴う抗NMDA受容体脳炎を検出するための非定型精神病診断基準の有用性 kn-title=The validity of atypical psychosis diagnostic criteria to detect anti-NMDA receptor encephalitis with psychiatric symptoms en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HINOTSUKenji en-aut-sei=HINOTSU en-aut-mei=Kenji kn-aut-name=樋之津健二 kn-aut-sei=樋之津 kn-aut-mei=健二 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220922 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=効率的なHEp-2細胞に対する計算機支援診断システムのための先進的深層学習手法 kn-title=Advanced Deep Learning Techniques for Efficient HEp-2 Computer-Aided Diagnosis Systems en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ASAAD MUSAED AHMED ANAAM en-aut-sei=ASAAD MUSAED AHMED ANAAM en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=岡山大学大学院ヘルスシステム統合科学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220922 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=胆嚢疾患に対して液状化細胞診を用いた経乳頭的胆嚢ドレナージ術の診断についての検討 kn-title=Accuracy of Endoscopic Transpapillary Gallbladder Drainage with Liquid-Based Cytology for Gallbladder Disease en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KAWAHARASoichiro en-aut-sei=KAWAHARA en-aut-mei=Soichiro kn-aut-name=河原聡一郎 kn-aut-sei=河原 kn-aut-mei=聡一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220922 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=小児心臓外科術後患者におけるPoint-of-Care機器を用いた血清クレアチニン濃度の評価と術後急性腎不全の診断に与える影響 kn-title=Evaluation of a point-of-care serum creatinine measurement device and the impact on diagnosis of acute kidney injury in pediatric cardiac patients: A retrospective, single center study en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KIMURASatoshi en-aut-sei=KIMURA en-aut-mei=Satoshi kn-aut-name=木村聡 kn-aut-sei=木村 kn-aut-mei=聡 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=侵襲性歯周炎の血液診断マーカー候補となる細胞外小胞由来マイクロRNAとその炎症誘導機構について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MoriAyano en-aut-sei=Mori en-aut-mei=Ayano kn-aut-name=森彩乃 kn-aut-sei=森 kn-aut-mei=彩乃 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=病理蛍光画像の解像度はヒトのみならずAI（人工知能）の診断にも影響を与える kn-title=The resolution of immunofluorescent pathological images affects diagnosis for not only artificial intelligence but also human en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakahashiKensaku en-aut-sei=Takahashi en-aut-mei=Kensaku kn-aut-name=髙橋謙作 kn-aut-sei=髙橋 kn-aut-mei=謙作 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=胆嚢癌患者における、診断、予後予測マーカーとしての細胞外小胞内のmicroRNAsとその役割としての可能性 kn-title=Extracellular vesicle-shuttled miRNAs as a diagnostic and prognostic biomarker and their potential roles in gallbladder cancer patients en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=UetaEijiro en-aut-sei=Ueta en-aut-mei=Eijiro kn-aut-name=上田英次郎 kn-aut-sei=上田 kn-aut-mei=英次郎 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=レクチンアレイによるIgA腎症診断を目的としたバイオマーカーの開発 kn-title=Development of urinary diagnostic biomarker for IgA nephropathy by lectin microarray en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OnishiYasuhiro en-aut-sei=Onishi en-aut-mei=Yasuhiro kn-aut-name=大西康博 kn-aut-sei=大西 kn-aut-mei=康博 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=133 cd-vols= no-issue=3 article-no= start-page=169 end-page=174 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20211201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The difficulty of understanding psychiatry : Thoughts from studentsʼ questions kn-title=精神科の分かりにくさについて　―学生たちの質問から考えること― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YamadaNorihito en-aut-sei=Yamada en-aut-mei=Norihito kn-aut-name=山田了士 kn-aut-sei=山田 kn-aut-mei=了士 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学学術研究院医歯薬学域　精神神経病態学 en-keyword=精神疾患の診断 kn-keyword=精神疾患の診断 en-keyword=バイオマーカー kn-keyword=バイオマーカー en-keyword=理念型 kn-keyword=理念型 en-keyword=大学病院精神科 kn-keyword=大学病院精神科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210924 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=成人 T 細胞性白血病/リンパ腫における SOX4 発現の診断的有用性 kn-title=Diagnostic Utility of SOX4 Expression in Adult T-Cell Leukemia/Lymphoma en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NasuAtsuko en-aut-sei=Nasu en-aut-mei=Atsuko kn-aut-name=那須篤子 kn-aut-sei=那須 kn-aut-mei=篤子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil=岡山大学大学院保健学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210924 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=前立腺癌生検におけるセカンドオピニオン病理診断による根治的前立腺摘除術標本との診断的妥当性の改善について kn-title=A second opinion pathology review improves the diagnostic concordance between prostate cancer biopsy and radical prostatectomy specimens en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MaeharaTakanori en-aut-sei=Maehara en-aut-mei=Takanori kn-aut-name=前原貴典 kn-aut-sei=前原 kn-aut-mei=貴典 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210924 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=脊髄腫瘍における術中病理診断と最終病理診断の一致率の検討 kn-title=Assessment of the Concordance Rate between Intraoperative Pathological Diagnosis and the Final Pathological Diagnosis of Spinal Cord Tumors en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MuraokaSosuke en-aut-sei=Muraoka en-aut-mei=Sosuke kn-aut-name=村岡聡介 kn-aut-sei=村岡 kn-aut-mei=聡介 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=133 cd-vols= no-issue=2 article-no= start-page=116 end-page=119 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Artificial intelligence research in gastroenterology kn-title=消化器内科におけるAI 研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KawaharaYoshiro en-aut-sei=Kawahara en-aut-mei=Yoshiro kn-aut-name=河原祥朗 kn-aut-sei=河原 kn-aut-mei=祥朗 aut-affil-num=1 ORCID= en-aut-name=HoriKeisuke en-aut-sei=Hori en-aut-mei=Keisuke kn-aut-name=堀圭介 kn-aut-sei=堀 kn-aut-mei=圭介 aut-affil-num=2 ORCID= affil-num=1 en-affil=Department of Practical Gastrointestinal Endoscopy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学学術研究院医歯薬学域　実践地域内視鏡学講座 affil-num=2 en-affil=Department of Medical Artificial Intelligence, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬総合研究科　医療AI 応用コース en-keyword=内視鏡診断 kn-keyword=内視鏡診断 en-keyword=computer-aided diagnosis kn-keyword=computer-aided diagnosis en-keyword=畳み込みニューラルネットワーク kn-keyword=畳み込みニューラルネットワーク en-keyword=早期胃癌 kn-keyword=早期胃癌 en-keyword=データ拡張 kn-keyword=データ拡張 END start-ver=1.4 cd-journal=joma no-vol=133 cd-vols= no-issue=2 article-no= start-page=109 end-page=112 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effectiveness of the National Early Warning Score in the diagnosis of sepsis as defined by Sepsis-3 criteria in cancer patients kn-title=担がん患者のSepsis-3 敗血症診断における早期警告スコアの有用性に関する検討：quick SOFA との比較 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The third international consensus definition of sepsis (Sepsis-3) recommends the quick sequential organ failure assessment (qSOFA) screening tool in patients with suspected infection. The Early Warning Score (EWS) helps to estimate mortality risk in emergency patients. The National EWS (NEWS) is a bedside score of six routine vital parameters. Few studies have compared qSOFA and NEWS in detecting suspected sepsis in cancer patients, so we compared them as a Sepsis-3 prognostic tool. [Methods] This is a retrospective observational single-center study. The study population consisted of cancer patients who entered the intensive care unit (ICU) between 2014 and 2016 for Sepsis-1 (based on systemic inflammatory response syndrome [SIRS] criteria). We calculated and compared the sensitivity and specificity of qSOFA and NEWS. We performed a receiver operating characteristic (ROC) curve analysis of NEWS in the diagnosis of Sepsis-3. [Results] Of the 62 patients admitted to the ICU for Sepsis-1, 42 had Sepsis-3. For qSOFA, sensitivity was 0.71 and specificity was 0.75. Exploratory analysis using the Youden index suggested that 9 may be the optimal score for NEWS. The sensitivity and specificity of NEWS at 9 points were 0.81 and 0.95, respectively. [Conclusion] We found NEWS to be more accurate than qSOFA in screening for Sepsis-3. en-copyright= kn-copyright= en-aut-name=LiuDan en-aut-sei=Liu en-aut-mei=Dan kn-aut-name=劉丹 kn-aut-sei=劉 kn-aut-mei=丹 aut-affil-num=1 ORCID= en-aut-name=MatsumiJunya en-aut-sei=Matsumi en-aut-mei=Junya kn-aut-name=松三絢弥 kn-aut-sei=松三 kn-aut-mei=絢弥 aut-affil-num=2 ORCID= en-aut-name=SaitaKosuke en-aut-sei=Saita en-aut-mei=Kosuke kn-aut-name=税田絋輔 kn-aut-sei=税田 kn-aut-mei=絋輔 aut-affil-num=3 ORCID= en-aut-name=SatoTetsufumi en-aut-sei=Sato en-aut-mei=Tetsufumi kn-aut-name=佐藤哲文 kn-aut-sei=佐藤 kn-aut-mei=哲文 aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Anesthesia and Intensive Care, National Cancer Center Hospital kn-affil=国立がん研究センター中央病院　麻酔・集中治療科 affil-num=2 en-affil=Department of Anesthesia and Intensive Care, National Cancer Center Hospital kn-affil=国立がん研究センター中央病院　麻酔・集中治療科 affil-num=3 en-affil=Department of Anesthesia and Intensive Care, National Cancer Center Hospital kn-affil=国立がん研究センター中央病院　麻酔・集中治療科 affil-num=4 en-affil=Department of Anesthesia and Intensive Care, National Cancer Center Hospital kn-affil=国立がん研究センター中央病院　麻酔・集中治療科 en-keyword=敗血症（sepsis） kn-keyword=敗血症（sepsis） en-keyword=スクリーニング（screcning） kn-keyword=スクリーニング（screcning） en-keyword=qSOFA kn-keyword=qSOFA en-keyword=EWS kn-keyword=EWS en-keyword=SOFA score kn-keyword=SOFA score END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=IgG4関連消化管病変の診断における胃生検の有用性 kn-title=In vitroデータに基づく代謝消失型化合物のヒト体内動態予測法に関する研究：生理学的薬物速度論におけるアルブミン媒介性肝移行の意義及びヒトiPS細胞由来小腸細胞の透過特性の応用 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MayumiKei en-aut-sei=Mayumi en-aut-mei=Kei kn-aut-name=眞弓慶 kn-aut-sei=眞弓 kn-aut-mei=慶 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=侵襲性歯周炎診断の血液バイオマーカーとしての細胞外小胞由来マイクロRNAの探索 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KomotoMina en-aut-sei=Komoto en-aut-mei=Mina kn-aut-name=河本美奈 kn-aut-sei=河本 kn-aut-mei=美奈 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=膵癌におけるEUSの血管浸潤診断能 kn-title=Diagnostic Ability of Convex-Arrayed Endoscopic Ultrasonography for Major Vascular Invasion in Pancreatic Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FujiiYuki en-aut-sei=Fujii en-aut-mei=Yuki kn-aut-name=藤井佑樹 kn-aut-sei=藤井 kn-aut-mei=佑樹 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=IgG4関連消化管病変の診断における胃生検の有用性 kn-title=Utility of gastric biopsy in diagnosing IgG4-related gastrointestinal disease en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=UchinoKaori en-aut-sei=Uchino en-aut-mei=Kaori kn-aut-name=内野かおり kn-aut-sei=内野 kn-aut-mei=かおり aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue=1 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year= dt-pub= dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case report on refractory ulcerative stomatitis associated with acute lymphoblastic leukemia kn-title=難治性潰瘍性口内炎を契機に判明した急性リンパ性白血病の 1 例 en-subtitle= kn-subtitle= en-abstract=We herein report a case on refractory ulcerative stomatitis associated with acute lymphoblastic leukemia. The female patient in her 60s showed refractory ulcer on her lower lip ; and the referral was made. Since pancytopenia was found by a blood test, hematologic disease was suspected. Bone marrow examination presented the diagnosis of Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia. Based on this diagnosis, steroid therapy had been initiated from four days after the first visit. On biopsy of lower lip, the pathological tissue did not show obvious infiltration of leukemia cells. Since oral manifestation may sometimes be an initial symptom of leukemia, an early diagnosis on leukemia patient with main complaint of oral symptom is critically important. Oral lesions, however, have various causes, and it thus often requires care of various clinical department. Based on this, it is considered to be important to implement treatment with cooperation among each clinical department. kn-abstract=症例は難治性潰瘍性口内炎を契機に判明した急性リンパ性白血病の 1 例である．患者は 60 歳台，女性．下口唇に難治性潰瘍を認め紹介となった．血液検査にて汎血球減少を認めたため，血液疾患を疑った．骨髄検査にて，Ph 染色体陰性急性 B 細胞性リンパ性白血病と診断され，初診の 4 日後からステロイド療法が開始された．なお，下口唇生検の病理組織には明らかな白血病細胞の浸潤は認めなかった．口腔症状が白血病の初発症状となることがあり，これを主訴に受診した白血病患者を早期診断することは大変重要である．しかし，口腔病変の原因は多彩であり，さまざまな科が対応することが多く，各科が連携して診療にあたることが重要と考える． en-copyright= kn-copyright= en-aut-name=IwakawaAsuka en-aut-sei=Iwakawa en-aut-mei=Asuka kn-aut-name=岩川明日香 kn-aut-sei=岩川 kn-aut-mei=明日香 aut-affil-num=1 ORCID= en-aut-name=KariyaAkifumi en-aut-sei=Kariya en-aut-mei=Akifumi kn-aut-name=假谷彰文 kn-aut-sei=假谷 kn-aut-mei=彰文 aut-affil-num=2 ORCID= en-aut-name=IshiharaHisashi en-aut-sei=Ishihara en-aut-mei=Hisashi kn-aut-name=石原久司 kn-aut-sei=石原 kn-aut-mei=久司 aut-affil-num=3 ORCID= en-aut-name=AkisadaNaoki en-aut-sei=Akisada en-aut-mei=Naoki kn-aut-name=秋定直樹 kn-aut-sei=秋定 kn-aut-mei=直樹 aut-affil-num=4 ORCID= en-aut-name=FujiSayaka en-aut-sei=Fuji en-aut-mei=Sayaka kn-aut-name=藤さやか kn-aut-sei=藤 kn-aut-mei=さやか aut-affil-num=5 ORCID= en-aut-name=AkagiSeiko en-aut-sei=Akagi en-aut-mei=Seiko kn-aut-name=赤木成子 kn-aut-sei=赤木 kn-aut-mei=成子 aut-affil-num=6 ORCID= en-aut-name=UmayaharaTakatsune en-aut-sei=Umayahara en-aut-mei=Takatsune kn-aut-name=馬屋原孝恒 kn-aut-sei=馬屋原 kn-aut-mei=孝恒 aut-affil-num=7 ORCID= en-aut-name=TamuraMaiko en-aut-sei=Tamura en-aut-mei=Maiko kn-aut-name=田村麻衣子 kn-aut-sei=田村 kn-aut-mei=麻衣子 aut-affil-num=8 ORCID= en-aut-name=TakeuchiMakoto en-aut-sei=Takeuchi en-aut-mei=Makoto kn-aut-name=竹内誠 kn-aut-sei=竹内 kn-aut-mei=誠 aut-affil-num=9 ORCID= en-aut-name=TakeuchiAyako en-aut-sei=Takeuchi en-aut-mei=Ayako kn-aut-name=竹内彩子 kn-aut-sei=竹内 kn-aut-mei=彩子 aut-affil-num=10 ORCID= affil-num=1 en-affil=Center for Graduate Medical Education, Okayama University Hospital kn-affil=岡山大学病院　卒後臨床研修センター affil-num=2 en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院　耳鼻咽喉科 affil-num=3 en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院　耳鼻咽喉科 affil-num=4 en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院　耳鼻咽喉科 affil-num=5 en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院　耳鼻咽喉科 affil-num=6 en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院　耳鼻咽喉科 affil-num=7 en-affil=Department of Dermatology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院　皮膚科 affil-num=8 en-affil=Department of Pathological Diagnosis, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院　病理診断科 affil-num=9 en-affil=Department of Hematology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院　血液内科 affil-num=10 en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院　耳鼻咽喉科 en-keyword=oral manifestations kn-keyword=oral manifestations en-keyword=leukemia kn-keyword=leukemia en-keyword=oral ulcer kn-keyword=oral ulcer en-keyword=initial symptoms kn-keyword=initial symptoms en-keyword=otolaryngology kn-keyword=otolaryngology END start-ver=1.4 cd-journal=joma no-vol=174 cd-vols= no-issue= article-no= start-page=9 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200727 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ADHD患児とその保護者の服薬アドヒアランス調査 en-subtitle= kn-subtitle= en-abstract= kn-abstract=【目的】注意欠如・多動症（ADHD）の患児とその保護者が薬物治療をどのように評価し，治療に向き合っているのかを明らかにする。【方法】ADHDの診断を受け，メチルフェニデート徐放剤およびアトモキセチンを処方された小１から高３までの患児94 人と保護者106人に質問紙調査と半構造化面接を行った。【結果】90％以上で服薬は規則正しく行われており，薬物治療に対する肯定的な評価は，患児・保護者で約80 ～ 90％と高かった。一方で，全面的に賛成しているわけではなく，約80％の保護者が否定的な意見も持っていた．否定的評価をする要因は，保護者は副作用を含めた長期的な影響への不安，患児は服薬の煩わしさや胃腸症状が多かった。定期的な薬物治療を続けているにも関わらず，効果と不安等を天秤にかけて治療を継続することへの積極的な支持は，患児・保護者で約50 ～ 60％であった。【結論】小児では，低年齢のため客観的に自身の状況を判断し，見通しをもって治療に参加することが難しい場合がある。患児へは胃腸症状への対処を，保護者へは治療の見通しや副作用について丁寧な説明を繰り返すことによって，薬物治療への否定的評価が軽減され，服薬アドヒアランスが向上する可能性がある。 en-copyright= kn-copyright= en-aut-name=OhmoriIori en-aut-sei=Ohmori en-aut-mei=Iori kn-aut-name=大守伊織 kn-aut-sei=大守 kn-aut-mei=伊織 aut-affil-num=1 ORCID= en-aut-name=MinamiKyoko en-aut-sei=Minami en-aut-mei=Kyoko kn-aut-name=南恭子 kn-aut-sei=南 kn-aut-mei=恭子 aut-affil-num=2 ORCID= en-aut-name=OhnoShigeru en-aut-sei=Ohno en-aut-mei=Shigeru kn-aut-name=大野繁 kn-aut-sei=大野 kn-aut-mei=繁 aut-affil-num=3 ORCID= en-aut-name=OkaMakio en-aut-sei=Oka en-aut-mei=Makio kn-aut-name=岡牧郎 kn-aut-sei=岡 kn-aut-mei=牧郎 aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科 affil-num=2 en-affil=Ex-Division of Developmental Studies and Support, Graduate School of Education (Master’s Course), Okayama University kn-affil=前　岡山大学大学院教育学研究科修士課程 affil-num=3 en-affil=Ohno Hagukumi Clinic kn-affil=医療法人大野はぐくみクリニック affil-num=4 en-affil=Department of Child Neurology, Okayama University Medical School kn-affil=岡山大学医学部附属病院小児神経 en-keyword=注意欠如・多動性症 kn-keyword=注意欠如・多動性症 en-keyword=ADHD kn-keyword=ADHD en-keyword=アドヒアランス kn-keyword=アドヒアランス en-keyword=メチルフェニデート kn-keyword=メチルフェニデート en-keyword=アトモキセチン kn-keyword=アトモキセチン END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=3 article-no= start-page=87 end-page=91 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=2019 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of acquired haemophilia A with epistaxis kn-title=鼻出血を契機に判明した後天性血友病 A の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=後天性血友病 A とは、凝固第Ⅷ因子に対する自己抗体が出現し出血症状を呈する疾患である。われわれは鼻出血を契機に発見された後天性血友病 A の 1 例を経験した。症例は 73 歳、男性。鼻出血を繰り返し、当科を受診した。出血点を認め焼灼するも再出血した。APTT 延長を認めたため当院血液内科に紹介し、後天性血友病と診断され現在治療中であり、治療開始後は再出血なく経過している。後天性血友病の初発症状は、皮下や筋肉内の出血が多く、鼻出血を契機に発見された症例はまれである。比較的まれな疾患ではあるが、診断が遅れれば、頭蓋内出血や腹腔内出血といった致死的な出血を来す可能性がある。早期診断・治療が重要であり、耳鼻咽喉科医も知識を有しておくべき疾患である。 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=秋定直樹 kn-aut-sei=秋定 kn-aut-mei=直樹 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=石原久司 kn-aut-sei=石原 kn-aut-mei=久司 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=竹内彩子 kn-aut-sei=竹内 kn-aut-mei=彩子 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤澤郁 kn-aut-sei=藤澤 kn-aut-mei=郁 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=赤木成子 kn-aut-sei=赤木 kn-aut-mei=成子 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=2 en-affil= kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=3 en-affil= kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=4 en-affil= kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=5 en-affil= kn-affil=岡山赤十字病院耳鼻咽喉科 en-keyword=鼻出血 kn-keyword=鼻出血 en-keyword=後天性血友病 kn-keyword=後天性血友病 en-keyword=凝固第Ⅷ因子 kn-keyword=凝固第Ⅷ因子 en-keyword=第Ⅷ因子インヒビター kn-keyword=第Ⅷ因子インヒビター en-keyword=出血性疾患 kn-keyword=出血性疾患 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺移植後患者に対する肺換気/血流 SPECT/CT を用いた閉塞性細気管支炎症候群の診断的価値に関する検討 kn-title=Diagnostic value of ventilation/perfusion single-photon emission computed tomography/computed tomography for bronchiolitis obliterans syndrome in patients after lung transplantation en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakashimaMasahiro en-aut-sei=Nakashima en-aut-mei=Masahiro kn-aut-name=中嶋真大 kn-aut-sei=中嶋 kn-aut-mei=真大 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil=岡山大学大学院保健学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Kinetic magnetic resonance imagingによる新しい上気道通気診断法の確⽴ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkaNaoki en-aut-sei=Oka en-aut-mei=Naoki kn-aut-name=岡直毅 kn-aut-sei=岡 kn-aut-mei=直毅 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=口腔癌治療前18F-FDG-PET/CTによるリンパ節外浸潤の診断能 kn-title=The Diagnostic Capacity of Pre-treatment 18F-FDG PET/CT for Predicting the Extranodular Spread of Lymph Node Metastases in Patients with Oral Squamous Cell Carcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FukuharaRyuichiro en-aut-sei=Fukuhara en-aut-mei=Ryuichiro kn-aut-name=福原隆一郎 kn-aut-sei=福原 kn-aut-mei=隆一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=膵神経内分泌腫瘍の術前グレード診断に対する造影EUSおよびTIC解析の有用性 kn-title=Contrast-enhanced harmonic endoscopic ultrasound using time-intensity curve analysis predicts pathological grade of pancreatic neuroendocrine neoplasm en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakadaSaimon en-aut-sei=Takada en-aut-mei=Saimon kn-aut-name=髙田斎文 kn-aut-sei=髙田 kn-aut-mei=斎文 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue=1 article-no= start-page=59 end-page=65 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=2019 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ポリドカノール硬化療法が有効であった遺伝性出血性末梢血管拡張症（オスラー病）による難治性鼻出血の2例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= 難治性鼻出血をきたす基礎疾患の一つに遺伝性出血性末梢血管拡張症（ Hereditary hemorrhagictelangiectasia：HHT，別名：オスラー病）がある．鼻出血を繰り返していた症例にポリドカノール硬化療法を行い，症状が改善した 2 例を経験したため報告する．症例 1：60 歳代男性．鼻出血を繰り返し，近医で鼻粘膜焼灼を反復したが改善せず当院受診．受診時は毎日鼻出血を繰り返していた．口腔・手指の拡張性小血管病変，胃の末梢血管拡張所見，肝動静脈奇形を認め，HHT と診断した．ポリドカノール硬化療法を実施したところ鼻出血回数は著減した．初回から現在までの 4 年間に計 4 回行い，経過は良好である．症例 2：40 歳代女性．父がHHT と診断されている．鼻出血を週 3 回ほど繰り返すため当院受診．手指・舌の拡張性小血管病変および肝動静脈奇形を認め，HHT と診断した．ポリドカノール硬化療法を 1 回実施し，2 年 7 ヶ月経過した現在も鼻出血なく経過している．簡便な手技で年単位の止血効果が得られ，患者の QOL 向上に寄与するポリドカノール硬化療法は HHT 患者で考慮すべき治療法と考える． en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=假谷彰文 kn-aut-sei=假谷 kn-aut-mei=彰文 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=石原久司 kn-aut-sei=石原 kn-aut-mei=久司 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=秋定直樹 kn-aut-sei=秋定 kn-aut-mei=直樹 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤澤郁 kn-aut-sei=藤澤 kn-aut-mei=郁 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤さやか kn-aut-sei=藤 kn-aut-mei=さやか aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=赤木成子 kn-aut-sei=赤木 kn-aut-mei=成子 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小橋春彦 kn-aut-sei=小橋 kn-aut-mei=春彦 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=竹内彩子 kn-aut-sei=竹内 kn-aut-mei=彩子 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山赤十字病院 affil-num=2 en-affil= kn-affil=岡山赤十字病院 affil-num=3 en-affil= kn-affil=岡山赤十字病院 affil-num=4 en-affil= kn-affil=岡山赤十字病院 affil-num=5 en-affil= kn-affil=岡山赤十字病院 affil-num=6 en-affil= kn-affil=岡山赤十字病院 affil-num=7 en-affil= kn-affil=岡山赤十字病院 affil-num=8 en-affil=岡山赤十字病院 kn-affil= en-keyword=Rendu-Osler-Weber disease kn-keyword=Rendu-Osler-Weber disease en-keyword=hereditary hemorrhagic telangiectasia kn-keyword=hereditary hemorrhagic telangiectasia en-keyword=refractory epistaxis kn-keyword=refractory epistaxis en-keyword=sclerotherapy kn-keyword=sclerotherapy en-keyword=polydocanol kn-keyword=polydocanol END start-ver=1.4 cd-journal=joma no-vol=131 cd-vols= no-issue=1 article-no= start-page=29 end-page=34 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Better diagnostic performance using computer-assisted diagnostic support systems in internal medicine kn-title=内科におけるコンピュータ利用診断支援システムによる診断改善 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The recent application of artificial intelligence（AI）to clinical medicine has confirmed the usefulness of AI for diagnostic imaging, histopathological examinations, and dermatologic screening. Clinical decision support systems are another promising area to which AI could contribute toward better clinical decisions. We have developed computer-assisted diagnostic support systems to reduce human diagnostic errors such as delayed diagnoses, misdiagnoses, and overdiagnoses. Our three Diagnosis Reminder（DR）systems include two AI systems that use machine learning in their diagnosis algorithms. Here, we compared the diagnostic accuracy of a DR-supported group with that of an unassisted physicians group, using three difficult patient cases provided by experts in general medicine. 　Our analyses revealed that the three AI diagnostic systems could not provide accurate differential diagnoses up to top 10 in all three patient cases because of incomplete data inputs for machine learning. However, the first DR system, which was developed by an experienced diagnostician over the last 35 years, showed very useful performance in reducing human diagnostic errors when it was used by an expert physician. The use of AI diagnostic systems by knowledgeable physicians will lead to better diagnostic performance. We also discuss the current scenario, future challenges, and prospects for AI diagnostic systems herein. en-copyright= kn-copyright= en-aut-name=KuriyamaYutaka en-aut-sei=Kuriyama en-aut-mei=Yutaka kn-aut-name=栗山裕 kn-aut-sei=栗山 kn-aut-mei=裕 aut-affil-num=1 ORCID= en-aut-name=Sota Yumi en-aut-sei=Sota en-aut-mei=Yumi kn-aut-name=曽田祐民 kn-aut-sei=曽田 kn-aut-mei=祐民 aut-affil-num=2 ORCID= en-aut-name=YanoAika en-aut-sei=Yano en-aut-mei=Aika kn-aut-name=矢野愛華 kn-aut-sei=矢野 kn-aut-mei=愛華 aut-affil-num=3 ORCID= en-aut-name=YasudaHideki en-aut-sei=Yasuda en-aut-mei=Hideki kn-aut-name=安田英己 kn-aut-sei=安田 kn-aut-mei=英己 aut-affil-num=4 ORCID= en-aut-name=IshiiOsamu en-aut-sei=Ishii en-aut-mei=Osamu kn-aut-name=石井修 kn-aut-sei=石井 kn-aut-mei=修 aut-affil-num=5 ORCID= en-aut-name=Saio Takeo en-aut-sei=Saio en-aut-mei=Takeo kn-aut-name=斉尾武郎 kn-aut-sei=斉尾 kn-aut-mei=武郎 aut-affil-num=6 ORCID= en-aut-name=TorigoeKeijiro en-aut-sei=Torigoe en-aut-mei=Keijiro kn-aut-name=鳥越恵治郎 kn-aut-sei=鳥越 kn-aut-mei=恵治郎 aut-affil-num=7 ORCID= en-aut-name=UedaTakeshi en-aut-sei=Ueda en-aut-mei=Takeshi kn-aut-name=上田剛士 kn-aut-sei=上田 kn-aut-mei=剛士 aut-affil-num=8 ORCID= en-aut-name=Shimizu Tarou en-aut-sei=Shimizu en-aut-mei=Tarou kn-aut-name=志水太郎 kn-aut-sei=志水 kn-aut-mei=太郎 aut-affil-num=9 ORCID= en-aut-name=TokudaYasuharu en-aut-sei=Tokuda en-aut-mei=Yasuharu kn-aut-name=徳田安春 kn-aut-sei=徳田 kn-aut-mei=安春 aut-affil-num=10 ORCID= affil-num=1 en-affil=Okayama University Medical School kn-affil=岡山大学医学部医学科 affil-num=2 en-affil=Okayama University Medical School kn-affil=岡山大学医学部医学科 affil-num=3 en-affil=Okayama University Medical School kn-affil=岡山大学医学部医学科 affil-num=4 en-affil=Yasuda Clinic of Internal Medicine kn-affil=医療法人安田内科医院 affil-num=5 en-affil=Torigoe-iin kn-affil=医療法人恵真会 鳥越医院 affil-num=6 en-affil=Health Management Office, SMBC Nikko Securities Inc kn-affil=SMBC日興証券　健康管理室 affil-num=7 en-affil=Torigoe-iin kn-affil=医療法人恵真会 鳥越医院 affil-num=8 en-affil=Emergency and General Internal Medicine, Rakuwakai Marutamachi Hospital kn-affil=洛和会丸太町病院　救急総合診療科 affil-num=9 en-affil=Department of Diagnostic and Generalist Medicine, Dokkyo Medical University kn-affil=獨協医科大学　総合診療医学 affil-num=10 en-affil=Muribushi Okinawa for Teaching Hospitals kn-affil=臨床研修病院群プロジェクト 群星沖縄臨床研修センター en-keyword=AI 診断システム (AI diagnostic systems) kn-keyword=AI 診断システム (AI diagnostic systems) en-keyword=診断思い出し (diagnosis reminder) kn-keyword=診断思い出し (diagnosis reminder) en-keyword=機械学習 (machine learning) kn-keyword=機械学習 (machine learning) en-keyword=診断エラー (human diagnostic errors) kn-keyword=診断エラー (human diagnostic errors) END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=地盤定数の空間分布評価に基づくため池堤体の効果的健全性診断法 kn-title=Effective Method to Diagnose Health of Earth-Fill Dams based on Evaluation of Spatial Variability of Soil Properties en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ImaideKazunari en-aut-sei=Imaide en-aut-mei=Kazunari kn-aut-name=今出和成 kn-aut-sei=今出 kn-aut-mei=和成 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil=岡山大学大学院環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=脛骨顆間隆起間距離は完全型円板状外側半月板の診断指標となる kn-title=Tibial eminence width can predict the presence of complete discoid lateral meniscus: A preliminary study. en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HinoTomohito en-aut-sei=Hino en-aut-mei=Tomohito kn-aut-name=日野知仁 kn-aut-sei=日野 kn-aut-mei=知仁 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=130 cd-vols= no-issue=2 article-no= start-page=67 end-page=71 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An effective case of peroral endoscopic myotomy for esophageal abnormal peristalsis after Heller-Dor myotomy kn-title=食道アカラシアバルーン拡張術およびHeller-Dor手術施行後の下部食道運動異常に対しPOEM（peroral endoscopic myotomy）が著効した1 例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= Esophageal achalasia is a disorder of the lower esophageal sphincter muscle. Our patient, a Japanese male in his 80's, had been experiencing dysphagia for almost 60 years. He was treated with balloon dilations and Heller-Dor 5 years prior to his present admission. Esophagogastroduodenoscopy, esophageal radiography, and high-myotomy manometry indicated that the symptoms were likely due to abnormal peristalsis. With the patient’s informed consent, we performed a peroral endoscopic myotomy（POEM）. The patient was discharged 4 days post-surgery. At the 6-month postoperative examination, no worsening of symptoms or relapse was observed. POEM is an excellent treatment method for esophageal achalasia from the perspective of therapeutic effect. We recommend that POEM be considered as the first-choice treatment for abnormal peristalsis after a Heller-Dor myotomy. en-copyright= kn-copyright= en-aut-name=SugiharaYuusaku en-aut-sei=Sugihara en-aut-mei=Yuusaku kn-aut-name=杉原雄策 kn-aut-sei=杉原 kn-aut-mei=雄策 aut-affil-num=1 ORCID= en-aut-name=HaradaKeita en-aut-sei=Harada en-aut-mei=Keita kn-aut-name=原田馨太 kn-aut-sei=原田 kn-aut-mei=馨太 aut-affil-num=2 ORCID= en-aut-name=KatoRyo en-aut-sei=Kato en-aut-mei=Ryo kn-aut-name=加藤諒 kn-aut-sei=加藤 kn-aut-mei=諒 aut-affil-num=3 ORCID= en-aut-name=YamauchiKenji en-aut-sei=Yamauchi en-aut-mei=Kenji kn-aut-name=山内健司 kn-aut-sei=山内 kn-aut-mei=健司 aut-affil-num=4 ORCID= en-aut-name=TakashimaShiho en-aut-sei=Takashima en-aut-mei=Shiho kn-aut-name=髙嶋志保 kn-aut-sei=髙嶋 kn-aut-mei=志保 aut-affil-num=5 ORCID= en-aut-name=YamasakiYasushi en-aut-sei=Yamasaki en-aut-mei=Yasushi kn-aut-name=山崎泰史 kn-aut-sei=山崎 kn-aut-mei=泰史 aut-affil-num=6 ORCID= en-aut-name=InokuchiToshihiro en-aut-sei=Inokuchi en-aut-mei=Toshihiro kn-aut-name=井口俊博 kn-aut-sei=井口 kn-aut-mei=俊博 aut-affil-num=7 ORCID= en-aut-name=TakaharaMasahiro en-aut-sei=Takahara en-aut-mei=Masahiro kn-aut-name=高原政宏 kn-aut-sei=高原 kn-aut-mei=政宏 aut-affil-num=8 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name=川野誠司 kn-aut-sei=川野 kn-aut-mei=誠司 aut-affil-num=9 ORCID= en-aut-name=HiraokaSakiko en-aut-sei=Hiraoka en-aut-mei=Sakiko kn-aut-name=平岡佐規子 kn-aut-sei=平岡 kn-aut-mei=佐規子 aut-affil-num=10 ORCID= en-aut-name=ManabeNoriaki en-aut-sei=Manabe en-aut-mei=Noriaki kn-aut-name=眞部紀明 kn-aut-sei=眞部 kn-aut-mei=紀明 aut-affil-num=11 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name=大塚文男 kn-aut-sei=大塚 kn-aut-mei=文男 aut-affil-num=12 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=13 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=3 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=7 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=8 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=9 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=10 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=11 en-affil=Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School kn-affil=川崎医科大学　検査診断学 affil-num=12 en-affil=Department of General Medicine, Okayama University Hospital kn-affil=岡山大学病院　総合内科 affil-num=13 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 en-keyword=POEM（peroral endoscopic myotomy） kn-keyword=POEM（peroral endoscopic myotomy） en-keyword=食道アカラシア（esophageal achalasia） kn-keyword=食道アカラシア（esophageal achalasia） END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180927 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=多房性エナメル上皮腫に対するMRI FLAIR法の診断的価値 kn-title=Diagnostic Value of Fluid-Attenuated Inversion Recovery Magnetic Resonance Imaging for Multilocular Ameloblastoma en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IrfanSugianto en-aut-sei=Irfan en-aut-mei=Sugianto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=10 article-no= start-page=49 end-page=51 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201809 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=MUSCAT-Assay法の個別化医療への応用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=免疫系が排除すべき異常な細胞を排除できなくなると「発がん」し、守るべき自己細胞を誤って攻撃して「自己免疫疾患」となる。我々はこの免疫監視の状態を反映するバイオマーカーとして自己抗体に注目している。医療現場でごく微量の血液から網羅的に自己抗体を迅速に定量評価するためには、全長・水溶性抗原の調整技術が鍵となる。個別化医療の対応を目指して我々が開発中の自己抗体の迅速測定システムの概要についてご紹介したい。 en-copyright= kn-copyright= en-aut-name=FutamiJun-ichiro en-aut-sei=Futami en-aut-mei=Jun-ichiro kn-aut-name=二見淳一郎 kn-aut-sei=二見 kn-aut-mei=淳一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学院ヘルスシテム統合科研究 en-keyword=がん免疫 kn-keyword=がん免疫 en-keyword=自己抗体 kn-keyword=自己抗体 en-keyword=腫瘍免疫応答 kn-keyword=腫瘍免疫応答 en-keyword=診断薬 kn-keyword=診断薬 en-keyword=タンパク質工学 kn-keyword=タンパク質工学 END start-ver=1.4 cd-journal=joma no-vol=130 cd-vols= no-issue=1 article-no= start-page=19 end-page=23 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Metaplastic carcinoma of the breast : Two cases kn-title=症例報告 乳腺化生癌の2例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= We treated two patients with a rare metaplastic carcinoma of the breast. Patient 1：A 32-year-old woman presented with a rapidly growing mass（ 7cm） in her right breast. We diagnosed cT3N0M0 Stage IIB breast cancer and performed a radical resection. The pathological diagnosis was triple-negative metaplastic carcinoma with a Ki-67 value ＞30%. Postoperative adjuvant chemotherapy and radiotherapy were performed. Patient 2：A 66-year-old postmenopausal woman presented with a left breast mass. We diagnosed cT1N0M0 Stage I breast cancer and performed a radical resection. The pathological diagnosis was triple-negative metaplastic carcinoma with a Ki-67 value ＞30%. Postoperative adjuvant chemotherapy was performed. Patients 1 and 2 have achieved relapse-free survivals of 1 year＋2 months and 10 months, respectively. Metaplastic carcinoma of the breast is a rare tumor, and its prognosis is not favorable. The only available treatment is that used for invasive ductal carcinoma；a more specific treatment has not been established. The accumulation of further similar cases and the development of a novel effective treatment are desired. en-copyright= kn-copyright= en-aut-name=MotokiTakayuki en-aut-sei=Motoki en-aut-mei=Takayuki kn-aut-name=元木崇之 kn-aut-sei=元木 kn-aut-mei=崇之 aut-affil-num=1 ORCID= en-aut-name=IwamotoTakayuki en-aut-sei=Iwamoto en-aut-mei=Takayuki kn-aut-name=岩本高行 kn-aut-sei=岩本 kn-aut-mei=高行 aut-affil-num=2 ORCID= en-aut-name=OmoriMasako en-aut-sei=Omori en-aut-mei=Masako kn-aut-name=大森昌子 kn-aut-sei=大森 kn-aut-mei=昌子 aut-affil-num=3 ORCID= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Surgery, Okayama Saiseikai General Hospital kn-affil=岡山済生会総合病院　外科 affil-num=2 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=岡山大学病院　新医療研究開発センター affil-num=3 en-affil=Department of Diagnostic Pathology, Kurashiki Medical Center kn-affil=倉敷成人病センター　病理診断科 affil-num=4 en-affil=Department of Palliative and Supportive Medicine, Okayama University Hospital kn-affil=岡山大学病院　緩和支持医療科 en-keyword=乳癌（breast cancer） kn-keyword=乳癌（breast cancer） en-keyword=化生癌（metaplastic carcinoma） kn-keyword=化生癌（metaplastic carcinoma） en-keyword=化学療法（chemotherapy） kn-keyword=化学療法（chemotherapy） END start-ver=1.4 cd-journal=joma no-vol=130 cd-vols= no-issue=1 article-no= start-page=13 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of a mesenteric desmoid tumor preoperatively distinguished from imaging findings kn-title=画像所見から術前診断が可能であった腸間膜デスモイドの1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 73-year-old woman was admitted for closer investigation into an abdominal tumor. Abdominal ultra-sonography, CT, and magnetic resonance imaging showed a discrete abdominal tumor. Especially on MRI, the tumor appeared as a relatively ill-defined whorled soft-tissue thickening within the mesenteric fat, causing angulation or speculation of adjacent bowel mesentery. Surgery was performed under a presumptive diagnosis of a mesojejunum desmoid. The tumor was invading the transverse mesocolon and mesojejunum as well as the third portion of the duodenum and the middle colic artery, and it was close to but apart from the superior mesenteric artery. The tumor was resected, including removal of part of the duodenum and transverse colon. The specimen contained a white solid tumor measuring 14×12×8cm. Pathologic examination showed differentiated fibroblasts and copious collagen fibers. The tumor was negative for CD34, c-kit, S-100, and α-SMA, but positive for β-catenin. On the basis of these findings, we established a diagnosis of mesenteric desmoid tumor of the small intestine. The patient has been followed postoperatively for 2 years, no sign of recurrence, to date. en-copyright= kn-copyright= en-aut-name=KawaiTakashi en-aut-sei=Kawai en-aut-mei=Takashi kn-aut-name=河合毅 kn-aut-sei=河合 kn-aut-mei=毅 aut-affil-num=1 ORCID= en-aut-name=WatanabeTakanori en-aut-sei=Watanabe en-aut-mei=Takanori kn-aut-name=渡邉貴紀 kn-aut-sei=渡邉 kn-aut-mei=貴紀 aut-affil-num=2 ORCID= en-aut-name=NobuhisaTetuji en-aut-sei=Nobuhisa en-aut-mei=Tetuji kn-aut-name=信久徹治 kn-aut-sei=信久 kn-aut-mei=徹治 aut-affil-num=3 ORCID= en-aut-name=MatumotoYusuke en-aut-sei=Matumoto en-aut-mei=Yusuke kn-aut-name=松本祐介 kn-aut-sei=松本 kn-aut-mei=祐介 aut-affil-num=4 ORCID= en-aut-name=KaiKyohei en-aut-sei=Kai en-aut-mei=Kyohei kn-aut-name=甲斐恭平 kn-aut-sei=甲斐 kn-aut-mei=恭平 aut-affil-num=5 ORCID= en-aut-name=SatoShiso en-aut-sei=Sato en-aut-mei=Shiso kn-aut-name=佐藤四三 kn-aut-sei=佐藤 kn-aut-mei=四三 aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Gastroenterological Surgery Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences|Department of Surgery, Japanese Red Cross Society Himeji Hospital kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学|姫路赤十字病院　外科 affil-num=2 en-affil=Department of Surgery, Japanese Red Cross Society Himeji Hospital kn-affil=姫路赤十字病院　外科 affil-num=3 en-affil=Department of Surgery, Japanese Red Cross Society Himeji Hospital kn-affil=姫路赤十字病院　外科 affil-num=4 en-affil=Department of Surgery, Japanese Red Cross Society Himeji Hospital kn-affil=姫路赤十字病院　外科 affil-num=5 en-affil=Department of Surgery, Japanese Red Cross Society Himeji Hospital kn-affil=姫路赤十字病院　外科 affil-num=6 en-affil=Department of Surgery, Japanese Red Cross Society Himeji Hospital kn-affil=姫路赤十字病院　外科 en-keyword=小腸間膜 (mesentery of the small intestine) kn-keyword=小腸間膜 (mesentery of the small intestine) en-keyword=デスモイド (desomoid) kn-keyword=デスモイド (desomoid) en-keyword=腸間膜腫瘍 (mesenteric tumor) kn-keyword=腸間膜腫瘍 (mesenteric tumor) END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=CD30陽性細胞傷害性T細胞の特徴的な分布は菊池・藤本病の診断の補助となる kn-title=Characteristic Distribution Pattern of CD30-positive Cytotoxic T Cells Aids Diagnosis of Kikuchi-Fujimoto Disease en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TabataTetsuya en-aut-sei=Tabata en-aut-mei=Tetsuya kn-aut-name=田端哲也 kn-aut-sei=田端 kn-aut-mei=哲也 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=高ヒスチジン糖タンパクの減少はSIRS患者において 敗血症診断予測の新規バイオマーカーとなる kn-title=Decrease in histidine-rich glycoprotein as a novel biomarker to predict sepsis among systemic inflammatory response syndrome en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KurodaKosuke en-aut-sei=Kuroda en-aut-mei=Kosuke kn-aut-name=黒田浩佐 kn-aut-sei=黒田 kn-aut-mei=浩佐 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170929 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=胸郭内インピーダンスから計算された新しいアルゴリズムは早期心不全イベントを診断しうる : 多施設共同MOMOTARO trial studyのサブ解析 kn-title=An improved algorithm calculated from intrathoracic impedance can precisely diagnose preclinical heart failure events: Sub-analysis of a multicenter MOMOTARO (Monitoring and Management of OptiVol Alert to Reduce Heart Failure Hospitalization) trial study en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MiyoshiAkihito en-aut-sei=Miyoshi en-aut-mei=Akihito kn-aut-name=三好章仁 kn-aut-sei=三好 kn-aut-mei=章仁 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=2 article-no= start-page=115 end-page=121 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Achalasia treated with per-oral endoscopic myotomy (POEM) kn-title=POEM (Per-Oral Endoscopic Myotomy) を施行した 食道アカラシアの1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= Esophageal achalasia is a disorder of the lower esophageal sphincter muscle. Patients present with dysphagia, chest pain, vomiting, and aspiration. Esophageal achalasia had traditionally been treated with esophageal achalasia balloon dilatation and the Heller-Dor method, but in recent years, the use of per-oral endoscopic myotomy (POEM) has increased. Our patient, a 39-yr-old male, began experiencing dysphagia 4 years prior to his referral to our hospital. Based on the results of esophagogastroduodenoscopy, esophageal radiography and high-resolution manometry, we made the diagnosis of esophageal achalasia (Chicago classification type I) . After informed consent from the patient and his family and approval from our hospital's ethics committee were obtained, we performed a POEM. The patient was discharged on the 4th day post-surgery. At the 1-year post-operative examination, no worsening of symptoms and no relapse were observed. POEM is an excellent treatment method for esophageal achalasia from the perspective of therapeutic effect and prevention of invasion. We recommend that it be considered as the first-choice treatment for achalasia. However, accessibility to the procedure itself is limited due to the few adequately trained operators worldwide. POEM should thus be performed by an expert operator at a high-volume center. en-copyright= kn-copyright= en-aut-name=SugiharaYuusaku en-aut-sei=Sugihara en-aut-mei=Yuusaku kn-aut-name=杉原雄策 kn-aut-sei=杉原 kn-aut-mei=雄策 aut-affil-num=1 ORCID= en-aut-name=HaradaKeita en-aut-sei=Harada en-aut-mei=Keita kn-aut-name=原田馨太 kn-aut-sei=原田 kn-aut-mei=馨太 aut-affil-num=2 ORCID= en-aut-name=KatoRyo en-aut-sei=Kato en-aut-mei=Ryo kn-aut-name=加藤諒 kn-aut-sei=加藤 kn-aut-mei=諒 aut-affil-num=3 ORCID= en-aut-name=YamauchiKenji en-aut-sei=Yamauchi en-aut-mei=Kenji kn-aut-name=山内健司 kn-aut-sei=山内 kn-aut-mei=健司 aut-affil-num=4 ORCID= en-aut-name=TakashimaShiho en-aut-sei=Takashima en-aut-mei=Shiho kn-aut-name=高嶋志保 kn-aut-sei=高嶋 kn-aut-mei=志保 aut-affil-num=5 ORCID= en-aut-name=TakeiDaisuke en-aut-sei=Takei en-aut-mei=Daisuke kn-aut-name=竹井大介 kn-aut-sei=竹井 kn-aut-mei=大介 aut-affil-num=6 ORCID= en-aut-name=InokuchiaToshihiro en-aut-sei=Inokuchia en-aut-mei=Toshihiro kn-aut-name=井口俊博 kn-aut-sei=井口 kn-aut-mei=俊博 aut-affil-num=7 ORCID= en-aut-name=TakaharaMasahiro en-aut-sei=Takahara en-aut-mei=Masahiro kn-aut-name=高原政宏 kn-aut-sei=高原 kn-aut-mei=政宏 aut-affil-num=8 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name=川野誠司 kn-aut-sei=川野 kn-aut-mei=誠司 aut-affil-num=9 ORCID= en-aut-name=HiraokaSakiko en-aut-sei=Hiraoka en-aut-mei=Sakiko kn-aut-name=平岡佐規子 kn-aut-sei=平岡 kn-aut-mei=佐規子 aut-affil-num=10 ORCID= en-aut-name=TanabeShunsuke en-aut-sei=Tanabe en-aut-mei=Shunsuke kn-aut-name=田辺俊介 kn-aut-sei=田辺 kn-aut-mei=俊介 aut-affil-num=11 ORCID= en-aut-name=NomaKazuhiro en-aut-sei=Noma en-aut-mei=Kazuhiro kn-aut-name=野間和宏 kn-aut-sei=野間 kn-aut-mei=和宏 aut-affil-num=12 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name=白川靖博 kn-aut-sei=白川 kn-aut-mei=靖博 aut-affil-num=13 ORCID= en-aut-name=ManabeNoriaki en-aut-sei=Manabe en-aut-mei=Noriaki kn-aut-name=眞部紀明 kn-aut-sei=眞部 kn-aut-mei=紀明 aut-affil-num=14 ORCID= en-aut-name=InoueHaruhiro en-aut-sei=Inoue en-aut-mei=Haruhiro kn-aut-name=井上晴洋 kn-aut-sei=井上 kn-aut-mei=晴洋 aut-affil-num=15 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=16 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=2 en-affil=Division of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=3 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=6 en-affil=Division of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=7 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=8 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=9 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=10 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=11 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 affil-num=12 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 affil-num=13 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 affil-num=14 en-affil=Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School kn-affil=川崎医科大学　検査診断学 affil-num=15 en-affil=Digestive Diseases Center, Showa University Koto Toyosu Hospital kn-affil=昭和大学江東豊洲病院　消化器センター affil-num=16 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 en-keyword=POEM kn-keyword=POEM en-keyword=食道アカラシア (esophageal achalasia) kn-keyword=食道アカラシア (esophageal achalasia) END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=2 article-no= start-page=111 end-page=114 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Adenocarcinoma in the jejunum 20 years after surgery for familial adenomatous polyposis kn-title=家族性大腸腺腫症術後20年後に小腸癌を発症した1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 58-year-old Japanese man visited a local clinic for the evaluation of a stomachache. He was diagnosed with intestinal obstruction. His medical history included a proctocolectomy at the age of 38 years, due to familial adenomatous polyposis (FAP). He was referred to our institution, where he underwent a computed tomography examination and endoscopy of the small intestine. The pathological diagnosis was adenocarcinoma. No invasive or metastatic lesions were observed. Therefore, partial resection of the ileum with lymphadenectomy and reconstruction of the ileostomy were performed. Pathological examination revealed that the tumor was type 2, pT3 (SS) , pN1, pPM0, pDM0, pRM0, INFb, ly1, v1, pEX0, PN0. Twenty-nine days after the surgery, the patient was diagnosed with lung metastasis and he underwent lung radiofrequency ablation. We suggest that long-term follow-up is necessary for patients after surgery for FAP, because of the risk of malignant disease developing in other organs. en-copyright= kn-copyright= en-aut-name=SugiharaYuusaku en-aut-sei=Sugihara en-aut-mei=Yuusaku kn-aut-name=杉原雄策 kn-aut-sei=杉原 kn-aut-mei=雄策 aut-affil-num=1 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name=川野誠司 kn-aut-sei=川野 kn-aut-mei=誠司 aut-affil-num=2 ORCID= en-aut-name=HaradaKeita en-aut-sei=Harada en-aut-mei=Keita kn-aut-name=原田馨太 kn-aut-sei=原田 kn-aut-mei=馨太 aut-affil-num=3 ORCID= en-aut-name=TakashimaShiho en-aut-sei=Takashima en-aut-mei=Shiho kn-aut-name=高嶋志保 kn-aut-sei=高嶋 kn-aut-mei=志保 aut-affil-num=4 ORCID= en-aut-name=TakeiDaisuke en-aut-sei=Takei en-aut-mei=Daisuke kn-aut-name=竹井大介 kn-aut-sei=竹井 kn-aut-mei=大介 aut-affil-num=5 ORCID= en-aut-name=InokuchiToshihiro en-aut-sei=Inokuchi en-aut-mei=Toshihiro kn-aut-name=井口俊博 kn-aut-sei=井口 kn-aut-mei=俊博 aut-affil-num=6 ORCID= en-aut-name=TakaharaMasahiro en-aut-sei=Takahara en-aut-mei=Masahiro kn-aut-name=高原政宏 kn-aut-sei=高原 kn-aut-mei=政宏 aut-affil-num=7 ORCID= en-aut-name=HiraokaSakiko en-aut-sei=Hiraoka en-aut-mei=Sakiko kn-aut-name=平岡佐規子 kn-aut-sei=平岡 kn-aut-mei=佐規子 aut-affil-num=8 ORCID= en-aut-name=MoriYoshiko en-aut-sei=Mori en-aut-mei=Yoshiko kn-aut-name=母里淑子 kn-aut-sei=母里 kn-aut-mei=淑子 aut-affil-num=9 ORCID= en-aut-name=KishimotoHiroyuki en-aut-sei=Kishimoto en-aut-mei=Hiroyuki kn-aut-name=岸本浩行 kn-aut-sei=岸本 kn-aut-mei=浩行 aut-affil-num=10 ORCID= en-aut-name=NagasakaTakeshi en-aut-sei=Nagasaka en-aut-mei=Takeshi kn-aut-name=永坂岳司 kn-aut-sei=永坂 kn-aut-mei=岳司 aut-affil-num=11 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=3 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=5 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=7 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=8 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=9 en-affil=Division of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 affil-num=10 en-affil=Division of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 affil-num=11 en-affil=Division of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 affil-num=12 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 en-keyword=家族性大腸腺腫症 (familial adenomatous polyposis) kn-keyword=家族性大腸腺腫症 (familial adenomatous polyposis) en-keyword=小腸癌 (jejunal cancer) kn-keyword=小腸癌 (jejunal cancer) en-keyword=小腸内視鏡検査 (small intestine endoscope) kn-keyword=小腸内視鏡検査 (small intestine endoscope) END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=放線菌由来L-メチオニン脱炭酸酵素の機能解析と臨床診断への活用 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HayashiMasaya en-aut-sei=Hayashi en-aut-mei=Masaya kn-aut-name=林将也 kn-aut-sei=林 kn-aut-mei=将也 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil=岡山大学大学院環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=小児てんかん患者における10年間のfollow-up研究：てんかん診断の経時的変化 kn-title=A ten-year follow-up cohort study of childhood epilepsy: Changes in epilepsy diagnosis with age en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HanaokaYoshiyuki en-aut-sei=Hanaoka en-aut-mei=Yoshiyuki kn-aut-name=花岡義行 kn-aut-sei=花岡 kn-aut-mei=義行 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue= article-no= start-page=193 end-page=202 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170327 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on Recognition and Knowledge of University Students Concerning the Prenatal Diagnosis; Present Status and Future Perspective in Japan kn-title=出生前診断に関する大学生の意識および知識に関する調査 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　本研究では、出生前診断に対する大学生の意識および知識に関する動向を明らかにすることを目的とした。大学生171名を対象に、出生前診断を積極的に行っていくことや、自分自身が受けることに対する意識、関連する知識などについての調査を行った。その結果、意識に関する質問では「積極的実施」「自身の受検」「中絶実施」において、知識に関する質問では「意義理解」「メリット/デメリットの理解」「目的理解」「情報の把握」において、「どちらともいえない」と回答した者が多かった。このことから、出生前診断は割り切ることのできない感情的葛藤をともなう問題であると同時に、対象者らは判断する情報を持っていないためにこのように回答したのではないかと思われ、自身の考えを深めたり、正しい知識に基づいた選択を促したりするために、教育が重要であることが示唆された。 en-copyright= kn-copyright= en-aut-name=MurakamiRie en-aut-sei=Murakami en-aut-mei=Rie kn-aut-name=村上理絵 kn-aut-sei=村上 kn-aut-mei=理絵 aut-affil-num=1 ORCID= en-aut-name=YoshitoshiMunehisa en-aut-sei=Yoshitoshi en-aut-mei=Munehisa kn-aut-name=吉利宗久 kn-aut-sei=吉利 kn-aut-mei=宗久 aut-affil-num=2 ORCID= en-aut-name=NakayaAkitaka en-aut-sei=Nakaya en-aut-mei=Akitaka kn-aut-name=仲矢明孝 kn-aut-sei=仲矢 kn-aut-mei=明孝 aut-affil-num=3 ORCID= affil-num=1 en-affil=Division of Special Education, Faculty of Education Okayama University kn-affil=岡山大学大学院教育学研究科 affil-num=2 en-affil=Division of Special Education, Faculty of Education Okayama University kn-affil=岡山大学大学院教育学研究科 affil-num=3 en-affil=Division of Special Education, Faculty of Education Okayama University kn-affil=岡山大学大学院教育学研究科 en-keyword=出生前診断 (prenatal diagnosis) kn-keyword=出生前診断 (prenatal diagnosis) en-keyword=障害 (disability) kn-keyword=障害 (disability) en-keyword=意識 (recognition) kn-keyword=意識 (recognition) en-keyword=知識 (knowledge) kn-keyword=知識 (knowledge) END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=1 article-no= start-page=35 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A refractory cutaneous-rectovesical fistula complicated with abdominal actinomycosis successfully treated with antibiotic therapy kn-title=抗菌化学療法で保存的に閉鎖した放線菌症による 難治性皮膚直腸膀胱瘻の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= The patient was a 35-year-old Japanese man diagnosed with appendicitis with abscess formation. An appendectomy was performed, but a refractory surgical wound infection developed, and eventually a cutaneous-rectovesical fistula was detected. In a review of the first-time CT scan, a small high-density construction resembling a bone from a fish was detected in the ileum. The histopathological examination revealed granules of actinomyces. These findings suggested that abdominal actinomycosis due to intestinal mucosal breakage by the fish bone caused the secondary appendicitis, and that after the appendectomy, residual actinomyces caused the cutaneous-rectovesical fistula. After the diagnosis, total parenteral nutrition and a long-term administration of antibiotics improved the patient's clinical symptoms, and the fistula closed within a month. Antibiotics were administered for 6 months, and there has been no recurrence for 6-1/2 years. Because actinomycosis is difficult to diagnose based on the typical clinical features, a direct identification of the infecting organism from a tissue sample or from sulfur granules is required for the definitive diagnosis. Actinomyces is also known to cause fistula formation, and intestinal penetration caused by a fish bone may indicate abdominal actinomycosis. A rectovesical fistula requires surgical intervention in most cases, but in cases caused by abdominal actinomycosis, such a fistula may be cured by conservative therapy, as in our patient's case. It is important to consider the possibility of actinomycosis when a refractory rectovesical fistula is observed. en-copyright= kn-copyright= en-aut-name=KatsuraYuki en-aut-sei=Katsura en-aut-mei=Yuki kn-aut-name=桂佑貴 kn-aut-sei=桂 kn-aut-mei=佑貴 aut-affil-num=1 ORCID= en-aut-name=MatsukawaHiroyoshi en-aut-sei=Matsukawa en-aut-mei=Hiroyoshi kn-aut-name=松川啓義 kn-aut-sei=松川 kn-aut-mei=啓義 aut-affil-num=2 ORCID= en-aut-name=KatoTakuya en-aut-sei=Kato en-aut-mei=Takuya kn-aut-name=加藤卓也 kn-aut-sei=加藤 kn-aut-mei=卓也 aut-affil-num=3 ORCID= en-aut-name=SugiharaMasahiro en-aut-sei=Sugihara en-aut-mei=Masahiro kn-aut-name=杉原正大 kn-aut-sei=杉原 kn-aut-mei=正大 aut-affil-num=4 ORCID= en-aut-name=OjimaYasutomo en-aut-sei=Ojima en-aut-mei=Yasutomo kn-aut-name=小島康知 kn-aut-sei=小島 kn-aut-mei=康知 aut-affil-num=5 ORCID= en-aut-name=ShiozakiShigehiro en-aut-sei=Shiozaki en-aut-mei=Shigehiro kn-aut-name=塩崎滋弘 kn-aut-sei=塩崎 kn-aut-mei=滋弘 aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital kn-affil=広島市立広島市民病院　外科 affil-num=2 en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital kn-affil=広島市立広島市民病院　外科 affil-num=3 en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital kn-affil=広島市立広島市民病院　外科 affil-num=4 en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital kn-affil=広島市立広島市民病院　外科 affil-num=5 en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital kn-affil=広島市立広島市民病院　外科 affil-num=6 en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital kn-affil=広島市立広島市民病院　外科 en-keyword=放線菌症 (actinomycosis) kn-keyword=放線菌症 (actinomycosis) en-keyword=皮膚直腸膀胱瘻 (cutaneous-rectovesical fistula) kn-keyword=皮膚直腸膀胱瘻 (cutaneous-rectovesical fistula) en-keyword=急性虫垂炎 (appendicitis) kn-keyword=急性虫垂炎 (appendicitis) END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=1 article-no= start-page=23 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Changes of colonic mucosa caused by long-term use and discontinuation of anthraquinone kn-title=アントラキノンの長期連用，及び摂取中止が大腸粘膜に与える影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= Anthraquinone, an anthracene derivatives, is widely used as a purgative medicine. The long-term use of anthraquinone is known to cause melanosis coli and elevated lesions in the colon. However, the clinical course of patients who take anthraquinone over a long term and those who discontinue the drug has not been fully investigated. Here we investigated 22 patients who had colonic mucosal changes ( i.e., melanosis coli and elevated lesions) who had been taking anthraquinone for at least one year and discontinued it. We classified the elevated lesions into two subtypes:the small-lesion, which included multiple small nodules that were ＜ 2 mm in dia., and the large-lesion, which included a single or multiple nodules of ≥ 2-mm dia. We used colonoscopy to investigate the changes of colonic lesions between before and after the discontinuation of anthraquinone. The results indicated that the nodules of the small-lesion group were lymphoid follicle hyperplasia. In the large-lesion group, adenoma was most frequently observed ( n＝118) , followed by hyperplastic polyp ( n＝52) and inflammatory changes with edema ( n＝22) . Melanosis coli and elevated lesions were decreased or invisible after the discontinuation of anthraquinone. Our findings thus suggest that the long-term use of anthraquinone may cause some type of elevated lesions due to chronic inflammation. It is recommended that the use of anthraquinone be limited to a short term. en-copyright= kn-copyright= en-aut-name=IwanoEiji en-aut-sei=Iwano en-aut-mei=Eiji kn-aut-name=岩野英二 kn-aut-sei=岩野 kn-aut-mei=英二 aut-affil-num=1 ORCID= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name=岩室雅也 kn-aut-sei=岩室 kn-aut-mei=雅也 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=3 ORCID= affil-num=1 en-affil=Kamogata Clinic kn-affil=鴨方クリニック affil-num=2 en-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学 affil-num=3 en-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学 en-keyword=アントラセン誘導体（anthracene derivatives) kn-keyword=アントラセン誘導体（anthracene derivatives) en-keyword=アントラキノン（anthraquinone） kn-keyword=アントラキノン（anthraquinone） en-keyword=大腸黒皮症（melanosis coli） kn-keyword=大腸黒皮症（melanosis coli） en-keyword=大腸メラノーシス（pseudomelanosis coli） kn-keyword=大腸メラノーシス（pseudomelanosis coli） en-keyword=リンパ濾胞過形成（lymphoid follicle hyperplasia） kn-keyword=リンパ濾胞過形成（lymphoid follicle hyperplasia） END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=3 article-no= start-page=201 end-page=205 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20161201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ectopic sebaceous glands in the esophagus that became evident over a three-year span kn-title=3 年間の内視鏡所見の変化を観察できた食道異所性皮脂腺の1 例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= A 43-year-old Japanese woman was diagnosed with ectopic sebaceous glands in the esophagus by esophagogastroduodenoscopy and biopsy. At the age of 46, typical ectopic sebaceous glands were recognized in the upper esophagus, whereas yellowish white granules were faintly observed in the lower esophagus. Esophagogastroduodenoscopy examinations were repeated when she was 47 and again at 50 years old, and the lesions in the lower esophagus had become more evident over the ensuing 3 years. Esophageal ectopic sebaceous glands are relatively infrequent, and there have been few case reports describing the progression of the endoscopic features. We also report the clinical and endoscopic features of the five similar cases with pathologically proven ectopic sebaceous glands in the esophagus. en-copyright= kn-copyright= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name=岩室雅也 kn-aut-sei=岩室 kn-aut-mei=雅也 aut-affil-num=1 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=2 ORCID= en-aut-name=HaradaKeita en-aut-sei=Harada en-aut-mei=Keita kn-aut-name=原田馨太 kn-aut-sei=原田 kn-aut-mei=馨太 aut-affil-num=3 ORCID= en-aut-name=KanzakiHiromitsu en-aut-sei=Kanzaki en-aut-mei=Hiromitsu kn-aut-name=神崎洋光 kn-aut-sei=神崎 kn-aut-mei=洋光 aut-affil-num=4 ORCID= en-aut-name=HoriKeisuke en-aut-sei=Hori en-aut-mei=Keisuke kn-aut-name=堀圭介 kn-aut-sei=堀 kn-aut-mei=圭介 aut-affil-num=5 ORCID= en-aut-name=KitaMasahide en-aut-sei=Kita en-aut-mei=Masahide kn-aut-name=喜多雅英 kn-aut-sei=喜多 kn-aut-mei=雅英 aut-affil-num=6 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name=川野誠司 kn-aut-sei=川野 kn-aut-mei=誠司 aut-affil-num=7 ORCID= en-aut-name=KawaharaYoshiro en-aut-sei=Kawahara en-aut-mei=Yoshiro kn-aut-name=河原祥朗 kn-aut-sei=河原 kn-aut-mei=祥朗 aut-affil-num=8 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name=田中健大 kn-aut-sei=田中 kn-aut-mei=健大 aut-affil-num=9 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name=山本和秀 kn-aut-sei=山本 kn-aut-mei=和秀 aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=3 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=7 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=8 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=9 en-affil=Department of Pathology, Okayama University Hospital kn-affil=岡山大学病院　病理診断科 affil-num=10 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 en-keyword=食道異所性脂腺（ectopic sebaceous glands in the esophagus） kn-keyword=食道異所性脂腺（ectopic sebaceous glands in the esophagus） en-keyword=粘膜下腫瘍（submucosal tumor） kn-keyword=粘膜下腫瘍（submucosal tumor） en-keyword=食道黄色腫（esophageal xanthoma） kn-keyword=食道黄色腫（esophageal xanthoma） END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=3 article-no= start-page=197 end-page=199 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20161201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Neuropathic pain due to metastatic invasive cancer successfully treated with intravenous lidocaine hydrochloride after failure of oral pregabalin kn-title=プレガバリン内服困難となった後にリドカイン塩酸塩静注が奏功した 転移性癌浸潤による神経障害性疼痛の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= The concomitant administration of adjuvant analgesics is recommended for neuropathic pain due to metastatic invasive cancer, because such pain may respond poorly to analgesic agents such as non-opioid analgesics and opioids. We report the case of a 44-year-old female patient with severe pain caused by a lumbosacral plexus injury associated with a failure of oral pregabalin（ 200 mg daily for 2 weeks）. We administered lidocaine hydrochloride（ drip infusion 960 mg/day）, which successfully relieved the pain. en-copyright= kn-copyright= en-aut-name=KunisueMitsuhisa en-aut-sei=Kunisue en-aut-mei=Mitsuhisa kn-aut-name=國末充央 kn-aut-sei=國末 kn-aut-mei=充央 aut-affil-num=1 ORCID= affil-num=1 en-affil=Tsubasa Clinic Okayama kn-affil=つばさクリニック岡山 en-keyword=緩和（palliative care） kn-keyword=緩和（palliative care） en-keyword=癌性疼痛（cancer pain） kn-keyword=癌性疼痛（cancer pain） en-keyword=腰仙骨神経叢障害（lumbosacral plexus disorders） kn-keyword=腰仙骨神経叢障害（lumbosacral plexus disorders） en-keyword=経口摂取困難（dysphagia） kn-keyword=経口摂取困難（dysphagia） en-keyword=リドカイン（lidocaine） kn-keyword=リドカイン（lidocaine） END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=3 article-no= start-page=183 end-page=189 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20161201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Electroencephalography：an old examination tool with a new meaning for childhood epilepsy kn-title=脳波：小児てんかんにおける古くて新しい検査 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KobayashiKatsuhiro en-aut-sei=Kobayashi en-aut-mei=Katsuhiro kn-aut-name=小林勝弘 kn-aut-sei=小林 kn-aut-mei=勝弘 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　発達神経病態学 en-keyword=頭皮脳波 kn-keyword=頭皮脳波 en-keyword=点頭てんかん kn-keyword=点頭てんかん en-keyword=てんかん外科 kn-keyword=てんかん外科 en-keyword=高周波振動 kn-keyword=高周波振動 en-keyword=時間・周波数分析 kn-keyword=時間・周波数分析 END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=2 article-no= start-page=111 end-page=116 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Magnified observation of spontaneous morphological changes of duodenal follicular lymphoma kn-title=拡大内視鏡検査にて形態変化を観察しえた十二指腸濾胞性リンパ腫の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 63-year-old Japanese woman was diagnosed with duodenal follicular lymphoma. The initial esophagogastroduodenoscopic examination with magnifying observation revealed opaque white spots and enlarged whitish villi. Nine months later, esophagogastroduodenoscopy showed that the size of the lymphoma lesion decreased, and only opaque white spots were visible. The histological analysis of biopsy samples obtained during the initial endoscopy examination showed both neoplastic follicles and an inter-follicular infiltration of lymphoma cells, whereas the biopsy samples obtained at the endoscopy performed 9 months later showed only neoplastic follicle formation. These results suggest that the magnifying endoscopic features may reflect the underlying pathological mechanisms : enlarged whitish villi are probably due to lymphoma cell infiltration in the inter-follicular area, and opaque white spots are probably caused by neoplastic follicle formation. en-copyright= kn-copyright= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name=岩室雅也 kn-aut-sei=岩室 kn-aut-mei=雅也 aut-affil-num=1 ORCID= en-aut-name=TakataKatsuyoshi en-aut-sei=Takata en-aut-mei=Katsuyoshi kn-aut-name=高田尚良 kn-aut-sei=高田 kn-aut-mei=尚良 aut-affil-num=2 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name=川野誠司 kn-aut-sei=川野 kn-aut-mei=誠司 aut-affil-num=3 ORCID= en-aut-name=KawaharaYoshiro en-aut-sei=Kawahara en-aut-mei=Yoshiro kn-aut-name=河原祥朗 kn-aut-sei=河原 kn-aut-mei=祥朗 aut-affil-num=4 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name=吉野正 kn-aut-sei=吉野 kn-aut-mei=正 aut-affil-num=5 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=2 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理） affil-num=3 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院 光学医療診療部 affil-num=4 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院 光学医療診療部 affil-num=5 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理） affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 en-keyword=消化管原発濾胞性リンパ腫（primary gastrointestinal follicular lymphoma） kn-keyword=消化管原発濾胞性リンパ腫（primary gastrointestinal follicular lymphoma） en-keyword=悪性リンパ腫（malignant lymphoma） kn-keyword=悪性リンパ腫（malignant lymphoma） en-keyword=拡大内視鏡検査（magnifying endoscopy） kn-keyword=拡大内視鏡検査（magnifying endoscopy） END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=5 article-no= start-page=19 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160512 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Development of Antibody Detection System to Evaluate Activation of Anti-Tumor Immune Respons kn-title=腫瘍免疫応答の活性化を測定する抗体検査技術の開発 en-subtitle= kn-subtitle= en-abstract= kn-abstract=がん免疫治療や関連の医薬品開発において、腫瘍に対する免疫応答のレベルを簡便な血液検査で定量評価ができる診断技術が必要だ。がんに対する免疫応答が亢進している際には、血液中に様々な抗がん抗原抗体が増加する。この抗体価の定量評価には、独自開発の変性タンパク質の可溶化技術の活用が強力な手段となる。 en-copyright= kn-copyright= en-aut-name=FutamiJunichiro en-aut-sei=Futami en-aut-mei=Junichiro kn-aut-name=二見淳一郎 kn-aut-sei=二見 kn-aut-mei=淳一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院自然科学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=個別化医療の実現に向けたコンパニオン診断薬の重要性とタンパク質可溶化技術の応用に関する研究 kn-title=The importance of companion diagnostics for personalized medicine and the application of protein solubilization technology en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NonomuraHidenori en-aut-sei=Nonomura en-aut-mei=Hidenori kn-aut-name=野々村英典 kn-aut-sei=野々村 kn-aut-mei=英典 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=イムノクロマトグラフィ法を用いたノロウイルス迅速診断キットの新生児および乳児糞便検体における評価 kn-title=Evaluation of rapid immunochromatographic tests for norovirus in neonatal and infant faecal specimens en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakahashiNobumasa en-aut-sei=Takahashi en-aut-mei=Nobumasa kn-aut-name=髙橋伸方 kn-aut-sei=髙橋 kn-aut-mei=伸方 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=1 article-no= start-page=27 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Behçetʼs disease complicated by ileocecal and esophageal perforation kn-title=回盲部潰瘍穿孔，食道潰瘍穿孔をきたした腸管Behçet 病の1 手術例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 36-year-old Japanese man known to have incomplete Behçet’s disease (oral aphthous ulcers, genital ulcers, skin lesions, and esophageal and ileocecal ulcers) was admitted to our hospital in January 2011 for abdominal pain. We administered corticosteroids and immunosuppressants. Two months later, we performed an ileocecal resection to control gastrointestinal bleeding from the ileocecal ulcers. High fever persisted after this surgery, and upper gastrointestinal endoscopy demonstrated ulcer penetration between the lower and abdominal esophagus. Eighteen days after the initial ileocecal resection, we performed a lower esophagus resection, gastric tube reconstruction and enterostomy, during which we confirmed a 5-mm-dia. perforated site at the posterior wall of the abdominal esophagus. Postoperative anastomotic leakage and empyema occurred, but they were relieved by thoracic drainage and empyema dissection. en-copyright= kn-copyright= en-aut-name=TsukumoYuta en-aut-sei=Tsukumo en-aut-mei=Yuta kn-aut-name=九十九悠太 kn-aut-sei=九十九 kn-aut-mei=悠太 aut-affil-num=1 ORCID= en-aut-name=KawamotoKazuyuki en-aut-sei=Kawamoto en-aut-mei=Kazuyuki kn-aut-name=河本和幸 kn-aut-sei=河本 kn-aut-mei=和幸 aut-affil-num=2 ORCID= en-aut-name=TakagiKosei en-aut-sei=Takagi en-aut-mei=Kosei kn-aut-name=高木弘誠 kn-aut-sei=高木 kn-aut-mei=弘誠 aut-affil-num=3 ORCID= en-aut-name=ChinKai en-aut-sei=Chin en-aut-mei=Kai kn-aut-name=陳開 kn-aut-sei=陳 kn-aut-mei=開 aut-affil-num=4 ORCID= en-aut-name=MatsubaYuri en-aut-sei=Matsuba en-aut-mei=Yuri kn-aut-name=松葉優里 kn-aut-sei=松葉 kn-aut-mei=優里 aut-affil-num=5 ORCID= en-aut-name=NagahisaYoshio en-aut-sei=Nagahisa en-aut-mei=Yoshio kn-aut-name=長久吉雄 kn-aut-sei=長久 kn-aut-mei=吉雄 aut-affil-num=6 ORCID= en-aut-name=OkabeMichio en-aut-sei=Okabe en-aut-mei=Michio kn-aut-name=岡部道雄 kn-aut-sei=岡部 kn-aut-mei=道雄 aut-affil-num=7 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name=白川靖博 kn-aut-sei=白川 kn-aut-mei=靖博 aut-affil-num=8 ORCID= en-aut-name=ItohTadashi en-aut-sei=Itoh en-aut-mei=Tadashi kn-aut-name=伊藤雅 kn-aut-sei=伊藤 kn-aut-mei=雅 aut-affil-num=9 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=2 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=4 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=5 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=6 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=7 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=9 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 en-keyword=ベーチェット病（Behçet’s disease） kn-keyword=ベーチェット病（Behçet’s disease） en-keyword=食道（esophagus） kn-keyword=食道（esophagus） en-keyword=回盲部（ileocecal） kn-keyword=回盲部（ileocecal） en-keyword=穿孔（perforation） kn-keyword=穿孔（perforation） en-keyword=手術（surgery） kn-keyword=手術（surgery） END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=1 article-no= start-page=21 end-page=25 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of mucinous adenocarcinoma of the duodenum and literature review of 16 cases reported in Japan kn-title=原発性十二指腸粘液癌の一例― 本邦報告16例の検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=　Primary mucinous adenocarcinoma of the duodenum is rare. Here we report a case we recently encountered, and we review 16 cases reported in Japan. An 82-year-old Japanese woman was admitted to our hospital complaining of abdominal pain and heartburn. An endoscopic examination revealed a Type 2 tumor in the descending limb of the duodenum, and endoscopically obtained specimens revealed a poorly differentiated adenocarcinoma. We performed a curative pancreatoduodenectomy with lymph node resection, and the surgical specimen revealed that the duodenum was the primary site of the mucinous adenocarcinoma. The patient is currently alive ＞ 1 year after the operation without any evidence of recurrence. Of the 16 patients reviewed, all patients had advanced tumors those depth were T3-T4. 9 patients had lymph node metastasis and 4 patients had peritoneal dissemination at the time of surgery. Since mucinous adenocarcinoma of the duodenum is often progressive cancer at a diagnosis, which is tend to have a worse prognosis than other histological types. en-copyright= kn-copyright= en-aut-name=HamanoIkumi en-aut-sei=Hamano en-aut-mei=Ikumi kn-aut-name=浜野郁美 kn-aut-sei=浜野 kn-aut-mei=郁美 aut-affil-num=1 ORCID= en-aut-name=MatsumotoYusuke en-aut-sei=Matsumoto en-aut-mei=Yusuke kn-aut-name=松本祐介 kn-aut-sei=松本 kn-aut-mei=祐介 aut-affil-num=2 ORCID= en-aut-name=EndoYoshikatsu en-aut-sei=Endo en-aut-mei=Yoshikatsu kn-aut-name=遠藤芳克 kn-aut-sei=遠藤 kn-aut-mei=芳克 aut-affil-num=3 ORCID= en-aut-name=WatanabeNaoki en-aut-sei=Watanabe en-aut-mei=Naoki kn-aut-name=渡邊直樹 kn-aut-sei=渡邊 kn-aut-mei=直樹 aut-affil-num=4 ORCID= en-aut-name=KaiKyouhei en-aut-sei=Kai en-aut-mei=Kyouhei kn-aut-name=甲斐恭平 kn-aut-sei=甲斐 kn-aut-mei=恭平 aut-affil-num=5 ORCID= en-aut-name=SatoShizou en-aut-sei=Sato en-aut-mei=Shizou kn-aut-name=佐藤四三 kn-aut-sei=佐藤 kn-aut-mei=四三 aut-affil-num=6 ORCID= en-aut-name=WaniYoji en-aut-sei=Wani en-aut-mei=Yoji kn-aut-name=和仁洋治 kn-aut-sei=和仁 kn-aut-mei=洋治 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=2 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=3 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=4 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=5 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=6 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=7 en-affil= kn-affil=姫路赤十字病院　病理診断科 en-keyword=原発性十二指腸癌（primary duodenal cancer） kn-keyword=原発性十二指腸癌（primary duodenal cancer） en-keyword=粘液癌（mucinous carcinoma） kn-keyword=粘液癌（mucinous carcinoma） en-keyword=膵頭十二指腸切除（pancreatoduodenectomy） kn-keyword=膵頭十二指腸切除（pancreatoduodenectomy） END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=3 article-no= start-page=219 end-page=222 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20151201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Drug-induced liver injury due to the long-term oral administration of rosuvastatin kn-title=長期のロスバスタチンカルシウム服用にて発症したと考えられる薬物性肝障害の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 67-year-old man was admitted to our hospital presenting with a liver injury. He had used several types of oral medication for the prior 2 years, including rosuvastatin calcium for hypertension, hyperlipidemia, and prostatic hypertrophy. His liver dysfunction was noted for the first time in February 2013, and at re-examination in March 2013 he showed exacerbation of the liver dysfunction, he was admitted to our hospital at that time. We stopped all of his oral medications, and his liver function improved steadily. We conducted a drug-induced lymphocyte transformation test (DLST), and the rosuvastatin calcium result was positive. He was diagnosed as having a drug-induced (by rosvastatin calcium) liver injury. He resumed oral medications other than rosuvastatin calcium from the time of discharge, with no exacerbation of liver dysfunction since then. Reports of drug-induced liver injury due to drugs with a long-term oral administration are extremely rare. We discuss the relevant literature herein. en-copyright= kn-copyright= en-aut-name=OonishiAyano en-aut-sei=Oonishi en-aut-mei=Ayano kn-aut-name=大西理乃 kn-aut-sei=大西 kn-aut-mei=理乃 aut-affil-num=1 ORCID= en-aut-name=KariyamaKazuya en-aut-sei=Kariyama en-aut-mei=Kazuya kn-aut-name=狩山和也 kn-aut-sei=狩山 kn-aut-mei=和也 aut-affil-num=2 ORCID= en-aut-name=WakutaAkiko en-aut-sei=Wakuta en-aut-mei=Akiko kn-aut-name=湧田暁子 kn-aut-sei=湧田 kn-aut-mei=暁子 aut-affil-num=3 ORCID= en-aut-name=NishimuraMamoru en-aut-sei=Nishimura en-aut-mei=Mamoru kn-aut-name=西村守 kn-aut-sei=西村 kn-aut-mei=守 aut-affil-num=4 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name=能祖一裕 kn-aut-sei=能祖 kn-aut-mei=一裕 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山市立市民病院 affil-num=2 en-affil= kn-affil=岡山市立市民病院 affil-num=3 en-affil= kn-affil=岡山市立市民病院 affil-num=4 en-affil= kn-affil=岡山市立市民病院 affil-num=5 en-affil= kn-affil=岡山市立市民病院 en-keyword=薬物性肝障害（drug induced liver injury） kn-keyword=薬物性肝障害（drug induced liver injury） en-keyword=ロスバスタチンカルシウム（Rosuvastatin） kn-keyword=ロスバスタチンカルシウム（Rosuvastatin） en-keyword=スタチン（statin） kn-keyword=スタチン（statin） en-keyword=DLST kn-keyword=DLST END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=3 article-no= start-page=213 end-page=218 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20151201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case report of giant ectopic pheochromocytoma conversion therapy with radioisotope therapy and chemotherapy followed by curative resection kn-title=術前内照射および化学療法が著効し,根治切除し得た巨大異所性褐色細胞腫の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 46-year-old man was found to be positive for occult blood at a medical checkup and was revealed to have a 14-cm tumor on the right side of abdominal aorta by a subsequent abdominal CT scan. The endocrinology laboratory data showed elevations in the levels of serum noradrenaline, and ectopic pheochromocytoma was suspected. The tumor was compressing the inferior vena cava and portal vein, the superior mesenteric artery and the pancreas. Since it would be difficult to cure by operation, neoadjuvant therapy was started using radioisotope therapy by I-131 metaiodobenzylguanidine (131I-MIBG) and chemotherapy (CVD therapy ; cyclophosphamide, vincristine, dacarbazine). He was treated with three courses of radioisotope therapy and 16 courses of chemotherapy, which significantly reduced the tumor size. This made radical resection possible ; we were able to avoid the merger excision of great vessels and other organs. On pathological and immunopathological findings, the tumor was diagnosed as ectopic　pheochromocytoma. Regarding the safety and curability of the treatment, neoadjuvant therapy may be useful in treating very large tumors that show invasion of other organs. en-copyright= kn-copyright= en-aut-name=YasuiKazuya en-aut-sei=Yasui en-aut-mei=Kazuya kn-aut-name=安井和也 kn-aut-sei=安井 kn-aut-mei=和也 aut-affil-num=1 ORCID= en-aut-name=UmedaYuzo en-aut-sei=Umeda en-aut-mei=Yuzo kn-aut-name=楳田祐三 kn-aut-sei=楳田 kn-aut-mei=祐三 aut-affil-num=2 ORCID= en-aut-name=KumanoKenjiro en-aut-sei=Kumano en-aut-mei=Kenjiro kn-aut-name=熊野健二郎 kn-aut-sei=熊野 kn-aut-mei=健二郎 aut-affil-num=3 ORCID= en-aut-name=TabataMasahiro en-aut-sei=Tabata en-aut-mei=Masahiro kn-aut-name=田端雅弘 kn-aut-sei=田端 kn-aut-mei=雅弘 aut-affil-num=4 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name=大塚文男 kn-aut-sei=大塚 kn-aut-mei=文男 aut-affil-num=5 ORCID= en-aut-name=YagiTakahito en-aut-sei=Yagi en-aut-mei=Takahito kn-aut-name=八木孝仁 kn-aut-sei=八木 kn-aut-mei=孝仁 aut-affil-num=6 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 en-keyword=異所性褐色細胞腫（ectopic pheochromocytoma） kn-keyword=異所性褐色細胞腫（ectopic pheochromocytoma） en-keyword=化学療法（chemo therapy） kn-keyword=化学療法（chemo therapy） en-keyword=131I-MIBG kn-keyword=131I-MIBG END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=3 article-no= start-page=203 end-page=207 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20151201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Non-high-output cardiac failure in patients undergoing hemodialysis through an arteriovenous shunt kn-title=透析シャント心不全―非過大シャント心不全 “Non-High-Output Cardiac Failure”の病態― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Hemodialysis-related heart failure has been considered to be associated with excessive blood flow through the arteriovenous (AV) shunt used for vascular access. However, some patients undergoing dialysis have heart failure in the absence of an increase in cardiac output (CO) related to shunt blood-flow loading because the loading cannot be compensated for by increasing CO. This condition may be challenging to manage ; thus, early diagnosis is important. Methods and Results: Twelve patients (mean age, 71 years ; 9 men) with end-stage renal disease, dialysis-related heart failure, a high brain natriuretic peptide (BNP) level, and a mean New York Heart Association (NYHA) class of II underwent AV shunt closure. Their cardiac index (CI), pre- and post-dialysis BNP levels, and several cardiac variables were assessed pre- and postoperatively. All patients achieved relief of heart failure symptoms and a reduction in NYHA class after AV closure, but six patients had a postoperative increase in CI (the "non-high-output" cardiac failure group), whereas the other six had a decrease in CI (the "high-output" cardiac failure group). The high-output patients had greater improvements in BNP levels and most cardiac variables compared to the non-high-output group ; therefore, the heart failure in the non-high-output patients was considered more serious than that in the high-output group. Conclusions: The selection of effective strategies for treating dialysis-related heart failure may depend partly on identifying which patients have non-high-output failure. Such identification requires serial measurements of BNP levels and evaluations of cardiac variables other than the ejection fraction. en-copyright= kn-copyright= en-aut-name=UgawaToyomu en-aut-sei=Ugawa en-aut-mei=Toyomu kn-aut-name=鵜川豊世武 kn-aut-sei=鵜川 kn-aut-mei=豊世武 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 en-keyword=心拍出量（cardiac output） kn-keyword=心拍出量（cardiac output） en-keyword=心不全（heart failure） kn-keyword=心不全（heart failure） en-keyword=脳性ナトリウム利尿ペプチド（brain natriuretic peptide） kn-keyword=脳性ナトリウム利尿ペプチド（brain natriuretic peptide） en-keyword=非過大シャント心不全（non-high-output cardiac failure） kn-keyword=非過大シャント心不全（non-high-output cardiac failure） en-keyword=腎臓（kidney） kn-keyword=腎臓（kidney） END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=造影CTによって診断された人工股関節全置換術後の静脈血栓症：選択的抗凝固薬使用群と未使用群との比較 kn-title=Venous Thromboembolism after Total Hip Arthroplasty Diagnosed by Enhanced Computed Tomography: Comparison of Selective Thromboprophylaxis and No Thromboprophylaxis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkadaYoshiki en-aut-sei=Okada en-aut-mei=Yoshiki kn-aut-name=岡田芳樹 kn-aut-sei=岡田 kn-aut-mei=芳樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=糖尿病診断用マーカー1,5-アンヒドロ-D-グルシトールを基質とするソルボース脱水素酵素とピラノース酸化酵素の機能解析と応用 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ArakiToshio en-aut-sei=Araki en-aut-mei=Toshio kn-aut-name=荒木俊雄 kn-aut-sei=荒木 kn-aut-mei=俊雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=疾患関連分子の複合画像診断を行うための新規核医学診断法の開発 kn-title=Development of novel nuclear medical imaging methods for multiple diagnoses of disease-related molecules en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HigashikawaKei en-aut-sei=Higashikawa en-aut-mei=Kei kn-aut-name=東川桂 kn-aut-sei=東川 kn-aut-mei=桂 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=冠動脈CTにおける安静時心筋perfusionイメージの補助的診断としての有用性に関する検討 kn-title=Additional diagnostic value of first-pass myocardial perfusion imaging without stress when combined with 64-row detector coronary CT angiography in patients with coronary artery disease en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OsawaKazuhiro en-aut-sei=Osawa en-aut-mei=Kazuhiro kn-aut-name=大澤和宏 kn-aut-sei=大澤 kn-aut-mei=和宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=1 article-no= start-page=35 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cholelithiasis with a cholecystoduodenal fistula complicated with paroxysmal nocturnal hemoglobinuria kn-title=胆嚢十二指腸瘻に対し合併症なく手術を行えた発作性夜間血色素尿症の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　In cases of paroxysmal nocturnal hemoglobinuria (PNH), attention must be paid to potential complications such as thrombosis and hemolysis due to perioperative stress and infection from complement activation. Here we present the case of a 61-year-old Japanese woman with PNH. We made the diagnosis of PNH when she was 28 years old, and we administered repeated steroid medication and erythrocyte transfusion. The patient's cholecystocholedocholithiasis with a cholecystoduodenal fistula was diagnosed based on a survey of the right hypochondriac pain. We performed endoscopic nasobiliary drainage (ENBD) for the prophylaxis of perioperative infection, plus a cholecystectomy and fistulectomy. There were no complications, including hemolysis attack, infection, thrombosis with irrigation erythrocyte transfusion, steroid cover, or the need for heparin administration during the perioperative period. The reduction of the complement activation is necessary in the perioperative management of PNH patients. The prevention of the development of acidosis and hypoxemia, the selection of washed red blood cells, steroid use, appropriate infection measures and thrombosis prophylaxis are all important for the prevention of complications. en-copyright= kn-copyright= en-aut-name=KatoTakuya en-aut-sei=Kato en-aut-mei=Takuya kn-aut-name=加藤卓也 kn-aut-sei=加藤 kn-aut-mei=卓也 aut-affil-num=1 ORCID= en-aut-name=MatsukawaHiroyoshi en-aut-sei=Matsukawa en-aut-mei=Hiroyoshi kn-aut-name=松川啓義 kn-aut-sei=松川 kn-aut-mei=啓義 aut-affil-num=2 ORCID= en-aut-name=ShiozakiShigehiro en-aut-sei=Shiozaki en-aut-mei=Shigehiro kn-aut-name=塩崎滋弘 kn-aut-sei=塩崎 kn-aut-mei=滋弘 aut-affil-num=3 ORCID= en-aut-name=FujiTomokazu en-aut-sei=Fuji en-aut-mei=Tomokazu kn-aut-name=藤智和 kn-aut-sei=藤 kn-aut-mei=智和 aut-affil-num=4 ORCID= en-aut-name=FujiwaraYasuhiro en-aut-sei=Fujiwara en-aut-mei=Yasuhiro kn-aut-name=藤原康宏 kn-aut-sei=藤原 kn-aut-mei=康宏 aut-affil-num=5 ORCID= en-aut-name=NinomiyaMotoki en-aut-sei=Ninomiya en-aut-mei=Motoki kn-aut-name=二宮基樹 kn-aut-sei=二宮 kn-aut-mei=基樹 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=2 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=3 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=4 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=5 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=6 en-affil= kn-affil=広島市立広島市民病院　外科 en-keyword=発作性夜間血色素尿症（PNH）（paroxysmal nocturnal hemoglobinuria (PNH)） kn-keyword=発作性夜間血色素尿症（PNH）（paroxysmal nocturnal hemoglobinuria (PNH)） en-keyword=胆嚢十二指腸瘻（cholecystoduodenal fistula） kn-keyword=胆嚢十二指腸瘻（cholecystoduodenal fistula） en-keyword=溶血発作（hemolysis） kn-keyword=溶血発作（hemolysis） END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=149 end-page=156 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on Recognition and Attitude of University Students Concerning the Prenatal Diagnosis ; Present Status and Future Perspective in Japan kn-title=出生前診断に関する大学生の意識調査 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　本研究では，出生前診断に対する大学生の意識を明らかにすることを目的とした。大学生74 名を対象に，出 生前診断を積極的に行っていくことや，自分自身が受けることに対する意識，関連する知識などについての調査 を行った。その結果，「出生前診断を積極的に行っていくこと」については，「どちらとも言えない」と回答した 者が多く，生前診断のメリット，デメリットを理解した上でこのように回答した者が多いことが示された。一方， 「自分（またはパートナー）が出生前診断を受けること」については，賛成と回答した者が多く，診断に対する 関心の高さが伺えた。「出生前診断の結果に基づいて人工的中絶を行うこと」については，反対と回答した者が 多く，「命の選別をすることになるから」などの意見が見られた。「出生前診断に関する知識」については，検査 の実施方法や検査後について自身の知識が不十分であると認識している者が多いことが明らかとなった。最後に， 今後の実施をめぐる課題について論じた。 en-copyright= kn-copyright= en-aut-name=Murakami(Yokouchi)Rie en-aut-sei=Murakami(Yokouchi) en-aut-mei=Rie kn-aut-name=村上（横内）理絵 kn-aut-sei=村上（横内） kn-aut-mei=理絵 aut-affil-num=1 ORCID= en-aut-name=YoshitoshiMunehisa en-aut-sei=Yoshitoshi en-aut-mei=Munehisa kn-aut-name=吉利宗久 kn-aut-sei=吉利 kn-aut-mei=宗久 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=広島大学大学院教育学研究科 affil-num=2 en-affil= kn-affil=岡山大学大学院教育学研究科 en-keyword=出生前診断 kn-keyword=出生前診断 en-keyword=障害 kn-keyword=障害 en-keyword=意識 kn-keyword=意識 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非侵襲的大腸癌遺伝子診断を目的とする、蛍光発現ウイルスを用いた血液循環腫瘍細胞回収システム kn-title=Fluorescence virus-guided capturing system of human colorectal circulating tumor cells for non-invasive companion diagnostics en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ShigeyasuKunitoshi en-aut-sei=Shigeyasu en-aut-mei=Kunitoshi kn-aut-name=重安邦俊 kn-aut-sei=重安 kn-aut-mei=邦俊 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=109 end-page=115 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Comprehensive treatment for gender identity disorder kn-title=性同一性障害に対する包括的治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NambaYuzaburo en-aut-sei=Namba en-aut-mei=Yuzaburo kn-aut-name=難波祐三郎 kn-aut-sei=難波 kn-aut-mei=祐三郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　ジェンダーセンター en-keyword=性同一性障害 kn-keyword=性同一性障害 en-keyword=包括的治療 kn-keyword=包括的治療 en-keyword=性別適合手術 kn-keyword=性別適合手術 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=narrow-band imagingとpit patternの診断精度は、トレーニングプログラム後に経験の少ない内視鏡医で有意に改善した kn-title=Diagnostic accuracy of narrow-band imaging and pit pattern analysis significantly improved for less-experienced endoscopists after an expanded training program en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HigashiReiji en-aut-sei=Higashi en-aut-mei=Reiji kn-aut-name=東玲治 kn-aut-sei=東 kn-aut-mei=玲治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue= article-no= start-page=121 end-page=128 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20041115 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Current Research Findings on DevelopmentaI Disdorder kn-title=発達障害の客観的脳機能評価に関する神経生理・心理学的研究の現状 en-subtitle= kn-subtitle= en-abstract= kn-abstract=近年の特殊教育をめぐる状況の変化に伴い，通常学級に在籍しながら教育を受ける子どもへの特別な教育的対応が求められるようになってきた。しかし，学習障害，注意欠陥/多動性障害，高機能自閉症など軽度発達障害の実態は未だ十分には把握されていない。そこで，本稿ではこれらの障害の診断上の指標策定や特別支援法の確立に資する目的で，当該領域の最新の研究成果を概説した。その結果，個別支援計画作成の際に役立つと思われる研究成果が多く認められた。また， LDや自閉症では側性化の評価が， AD/HDではDoparnine transporterの測定などが診断上の手がかりとして注目され，臨床応用に向けた今後の研究が期待される。 en-copyright= kn-copyright= en-aut-name=KadoYoko en-aut-sei=Kado en-aut-mei=Yoko kn-aut-name=加戸陽子 kn-aut-sei=加戸 kn-aut-mei=陽子 aut-affil-num=1 ORCID= en-aut-name=TamakiRyoko en-aut-sei=Tamaki en-aut-mei=Ryoko kn-aut-name=玉木涼子 kn-aut-sei=玉木 kn-aut-mei=涼子 aut-affil-num=2 ORCID= en-aut-name=SanadaSatoshi en-aut-sei=Sanada en-aut-mei=Satoshi kn-aut-name=眞田敏 kn-aut-sei=眞田 kn-aut-mei=敏 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=兵庫教育大学大学院連合学校教育学研究科 affil-num=2 en-affil= kn-affil=岡山大学教育学部障害児教育講座 affil-num=3 en-affil= kn-affil=岡山大学教育学部障害児教育講座 en-keyword=Developrnental disorder kn-keyword=Developrnental disorder en-keyword=Autism kn-keyword=Autism en-keyword=AD/HD kn-keyword=AD/HD en-keyword=Neurophysiology kn-keyword=Neurophysiology en-keyword=Neuropsychology kn-keyword=Neuropsychology END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=1 article-no= start-page=59 end-page=63 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Drug interaction (29. drug interaction of steroids) kn-title=薬物相互作用(29―ステロイドの薬物相互作用） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HayashiYouko en-aut-sei=Hayashi en-aut-mei=Youko kn-aut-name=林瑶子 kn-aut-sei=林 kn-aut-mei=瑶子 aut-affil-num=1 ORCID= en-aut-name=NawaHideki en-aut-sei=Nawa en-aut-mei=Hideki kn-aut-name=名和秀起 kn-aut-sei=名和 kn-aut-mei=秀起 aut-affil-num=2 ORCID= en-aut-name=KitamuraYoshihisa en-aut-sei=Kitamura en-aut-mei=Yoshihisa kn-aut-name=北村佳久 kn-aut-sei=北村 kn-aut-mei=佳久 aut-affil-num=3 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name=千堂年昭 kn-aut-sei=千堂 kn-aut-mei=年昭 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=2 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=3 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=4 en-affil= kn-affil=岡山大学病院　薬剤部 END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=1 article-no= start-page=25 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of a one-step nucleic acid amplification (OSNA) assay for sentinel lymph node metastases in early breast cancer kn-title=早期乳癌におけるOne-step Nucleic Acid Amplification(OSNA)法によるセンチネルリンパ節転移診断の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　Introduction: The one-step nucleic acid amplification (OSNA) assay is a new method to detect sentinel lymph node (SLN) metastases using cytokeratin 19 (CK19) mRNA in early breast cancer. Here we retrospectively analyzed the advantages and disadvantages of the OSNA assay. 　Methods: In a trial period, SLNs were divided into two sections, and we examined one side using the OSNA assay. The other side was examined by pathologists. After this period, we examined whole SLNs using only the OSNA assay. The patients with positive nodes by OSNA assay and/or pathology required axillary dissection. 　Results: We examined 27 primary breast cancer patients (36 SLNs) during the trial period. The overall concordance rate between the OSNA assay and pathology results was 91%. In the later period, 157 patients (217 SLNs) were examined. The CK19-positive rate obtained by the OSNA assay was 16.5% (macrometastases OSNA (++) : 7.2%, micrometastases OSNA (+) : 9.2%). The non-SLN positive rate among the CK19-positivecases was 23%. The OSNA assay's false negative was one case in which the expression of CK-19 on the primary tumor and lymph node was not detected. 　Conclusions: Our OSNA assay results were comparable to those obtained using a conventional pathological technique. Pathologists and laboratory technicians could save time and effort by using the OSNA assay when seeking the precise diagnosis during surgery. en-copyright= kn-copyright= en-aut-name=MizooTaeko en-aut-sei=Mizoo en-aut-mei=Taeko kn-aut-name=溝尾妙子 kn-aut-sei=溝尾 kn-aut-mei=妙子 aut-affil-num=1 ORCID= en-aut-name=ShienTadahiko en-aut-sei=Shien en-aut-mei=Tadahiko kn-aut-name=枝園忠彦 kn-aut-sei=枝園 kn-aut-mei=忠彦 aut-affil-num=2 ORCID= en-aut-name=ItoMaiko en-aut-sei=Ito en-aut-mei=Maiko kn-aut-name=伊藤麻衣子 kn-aut-sei=伊藤 kn-aut-mei=麻衣子 aut-affil-num=3 ORCID= en-aut-name=NogamiTomohiro en-aut-sei=Nogami en-aut-mei=Tomohiro kn-aut-name=野上智弘 kn-aut-sei=野上 kn-aut-mei=智弘 aut-affil-num=4 ORCID= en-aut-name=IwamotoTakayuki en-aut-sei=Iwamoto en-aut-mei=Takayuki kn-aut-name=岩本高行 kn-aut-sei=岩本 kn-aut-mei=高行 aut-affil-num=5 ORCID= en-aut-name=MotokiTakayuki en-aut-sei=Motoki en-aut-mei=Takayuki kn-aut-name=元木崇之 kn-aut-sei=元木 kn-aut-mei=崇之 aut-affil-num=6 ORCID= en-aut-name=TairaNaruto en-aut-sei=Taira en-aut-mei=Naruto kn-aut-name=平成人 kn-aut-sei=平 kn-aut-mei=成人 aut-affil-num=7 ORCID= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=8 ORCID= en-aut-name=DoiharaHiroyoshi en-aut-sei=Doihara en-aut-mei=Hiroyoshi kn-aut-name=土井原博義 kn-aut-sei=土井原 kn-aut-mei=博義 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　乳腺・内分泌外科 affil-num=2 en-affil= kn-affil=岡山大学病院　乳腺・内分泌外科 affil-num=3 en-affil= kn-affil=岡山大学病院　乳腺・内分泌外科 affil-num=4 en-affil= kn-affil=岡山大学病院　乳腺・内分泌外科 affil-num=5 en-affil= kn-affil=岡山大学病院　乳腺・内分泌外科 affil-num=6 en-affil= kn-affil=岡山大学病院　乳腺・内分泌外科 affil-num=7 en-affil= kn-affil=岡山大学病院　乳腺・内分泌外科 affil-num=8 en-affil= kn-affil=岡山大学病院　乳腺・内分泌外科 affil-num=9 en-affil= kn-affil=岡山大学病院　乳腺・内分泌外科 en-keyword=OSNA法（OSNA method） kn-keyword=OSNA法（OSNA method） en-keyword=センチネルリンパ節（sentinel lymph node） kn-keyword=センチネルリンパ節（sentinel lymph node） en-keyword=micrometastases kn-keyword=micrometastases en-keyword=CK-19 kn-keyword=CK-19 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=新国際分類により診断された早期肺腺癌のGLUT1とKi-67の発現の意義 kn-title=Impact of GLUT1 and Ki-67 expression on early-stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MakiYuho en-aut-sei=Maki en-aut-mei=Yuho kn-aut-name=牧佑歩 kn-aut-sei=牧 kn-aut-mei=佑歩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=55歳またはそれ以上の高齢で診断された無症候性原発性胆汁性肝硬変患者の死亡率は健常人の死亡率と同等である kn-title=Mortality rate of patients with asymptomatic primary biliary cirrhosis diagnosed at age 55 years or older is similar to that of the general population en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KubotaJunichi en-aut-sei=Kubota en-aut-mei=Junichi kn-aut-name=窪田淳一 kn-aut-sei=窪田 kn-aut-mei=淳一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=3 article-no= start-page=239 end-page=242 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of appendiceal diverticulum resected by laparoscopic surgery with preoperative diagnosis of appendiceal tumor kn-title=虫垂腫瘍と術前診断し腹腔鏡下手術を行った虫垂仮性憩室症の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　Appendiceal diverticulum is rare. We encountered a case of appendiceal diverticulum with chronic appendicitis. A 56-year-old man presented to our hospital with right lower abdominal pain. An abdominal computed tomography (CT) scan showed swelling of the appendix body and the wall thickness of the base of the appendix. Due to the possibility of appendiceal tumor, we performed a laparoscopy-assisted ileocecal resection with lymph node dissection. The appendix had a diverticulum with chronic inflammation, but it did not have a neoplastic lesion. en-copyright= kn-copyright= en-aut-name=NinomiyaTakayuki en-aut-sei=Ninomiya en-aut-mei=Takayuki kn-aut-name=二宮卓之 kn-aut-sei=二宮 kn-aut-mei=卓之 aut-affil-num=1 ORCID= en-aut-name=OjimaYasutomo en-aut-sei=Ojima en-aut-mei=Yasutomo kn-aut-name=小島康知 kn-aut-sei=小島 kn-aut-mei=康知 aut-affil-num=2 ORCID= en-aut-name=HaranoMasao en-aut-sei=Harano en-aut-mei=Masao kn-aut-name=原野雅生 kn-aut-sei=原野 kn-aut-mei=雅生 aut-affil-num=3 ORCID= en-aut-name=OhnoSatoshi en-aut-sei=Ohno en-aut-mei=Satoshi kn-aut-name=大野聡 kn-aut-sei=大野 kn-aut-mei=聡 aut-affil-num=4 ORCID= en-aut-name=ShiozakiShigehiro en-aut-sei=Shiozaki en-aut-mei=Shigehiro kn-aut-name=塩崎滋弘 kn-aut-sei=塩崎 kn-aut-mei=滋弘 aut-affil-num=5 ORCID= en-aut-name=NinomiyaMotoki en-aut-sei=Ninomiya en-aut-mei=Motoki kn-aut-name=二宮基樹 kn-aut-sei=二宮 kn-aut-mei=基樹 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=2 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=3 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=4 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=5 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=6 en-affil= kn-affil=広島市立広島市民病院　外科 en-keyword=虫垂憩室症（appendiceal diverculum） kn-keyword=虫垂憩室症（appendiceal diverculum） en-keyword=腹腔鏡手術（laparoscopic surgery） kn-keyword=腹腔鏡手術（laparoscopic surgery） en-keyword=虫垂腫瘍（appendiceal tumor） kn-keyword=虫垂腫瘍（appendiceal tumor） END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=3 article-no= start-page=235 end-page=238 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Two operated cases of mesenteric abscess caused by penetration of the transverse colon associated with a diverticulum kn-title=横行結腸憩室穿通による腸間膜膿瘍に対して手術を施行した２症例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We encountered 2 cases of penetration of fecal matter through a diverticulum of the transverse colon, which is a rare disease. Case 1 was a 33-year-old man who was examined in the clinic with a complaint of epigastralgia. Tenderness and muscular defense were found in the upper abdomen. On abdominal CT examination, wall thickening and increased fat concentration were seen in the transverse colon. He was diagnosed with peritonitis and underwent emergency surgery. On laparotomy, a tumor mass was found in the transverse colon close to the liver curvature. The patient was diagnosed with mesenteric abscess due to penetration of fecal matter through a diverticulum of the transverse colon. Right hemicolectomy was carried out. Case 2 was a 43-year-old woman who was examined in the clinic with a complaint of right lower abdominal pain. Muscular defense and rebound tenderness were found in the lower abdomen. On abdominal CT examination, abscess formation was seen in the right lower abdomen. She was diagnosed with peritonitis and underwent emergency surgery. On laparotomy, a tumor mass was found in the transverse colon. The patient was diagnosed with mesenteric abscess due to penetration of the transverse colon associated with a diverticulum. Partial removal of the transverse colon was carried out. en-copyright= kn-copyright= en-aut-name=MaedaNaoaki en-aut-sei=Maeda en-aut-mei=Naoaki kn-aut-name=前田直見 kn-aut-sei=前田 kn-aut-mei=直見 aut-affil-num=1 ORCID= en-aut-name=KondoHidenori en-aut-sei=Kondo en-aut-mei=Hidenori kn-aut-name=近藤秀則 kn-aut-sei=近藤 kn-aut-mei=秀則 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=医療法人敬和会近藤病院　外科 affil-num=2 en-affil= kn-affil=医療法人敬和会近藤病院　外科 en-keyword=横行結腸憩室（transverse colon diverticulum） kn-keyword=横行結腸憩室（transverse colon diverticulum） en-keyword=腸間膜内穿通（mesenteric penetration） kn-keyword=腸間膜内穿通（mesenteric penetration） en-keyword=腸間膜膿瘍（mesenteric abscess） kn-keyword=腸間膜膿瘍（mesenteric abscess） END start-ver=1.4 cd-journal=joma no-vol=特別号2002 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020820 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=算数学力診断評価を生かす「数と計算」の指導　―確かな算数の学力の育成を目指して― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山大学算数・数学教育学会算数学力診断調査プロジェクト kn-aut-sei=岡山大学算数・数学教育学会算数学力診断調査プロジェクト kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=特別号2003 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20031101 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=評価を生かした新しい中学校「数量関係」の指導　―「つまずき」の顕著な指導事項の授業改善を中心に確かな学力の育成を目指して― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山大学算数・数学教育学会中学校「数学」学力診断プロジェクト kn-aut-sei=岡山大学算数・数学教育学会中学校「数学」学力診断プロジェクト kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=1 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980613 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=新学力観にたつ「算数学力診断調査」について ―調査問題作成の方策と調査結果(中間報告)― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高橋敏雄 kn-aut-sei=高橋 kn-aut-mei=敏雄 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=黒崎東洋郎 kn-aut-sei=黒崎 kn-aut-mei=東洋郎 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=深井文雄 kn-aut-sei=深井 kn-aut-mei=文雄 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=福田博雅 kn-aut-sei=福田 kn-aut-mei=博雅 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片山晴夫 kn-aut-sei=片山 kn-aut-mei=晴夫 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=新瀬陽子 kn-aut-sei=新瀬 kn-aut-mei=陽子 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=糸島耕太郎 kn-aut-sei=糸島 kn-aut-mei=耕太郎 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= 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kn-title=オオムギ縞萎縮病の汁液接種検定並びに診断 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=InouyeNarinobu en-aut-sei=Inouye en-aut-mei=Narinobu kn-aut-name=井上成信 kn-aut-sei=井上 kn-aut-mei=成信 aut-affil-num=1 ORCID= en-aut-name=MaedaTakanori en-aut-sei=Maeda en-aut-mei=Takanori kn-aut-name=前田孚憲 kn-aut-sei=前田 kn-aut-mei=孚憲 aut-affil-num=2 ORCID= en-aut-name=MitsuhataKōji en-aut-sei=Mitsuhata en-aut-mei=Kōji kn-aut-name=光畑興二 kn-aut-sei=光畑 kn-aut-mei=興二 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=4 article-no= start-page=269 end-page=277 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Detection of Leek Yellow Stripe Virus by Dot-immunobinding Assay kn-title=Leek yellow stripe virusのdot-immunobinding assayによる検出ならびにその診断への利用 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NodaChiyoichi en-aut-sei=Noda en-aut-mei=Chiyoichi kn-aut-name=野田千代一 kn-aut-sei=野田 kn-aut-mei=千代一 aut-affil-num=1 ORCID= en-aut-name=MaedaTakanori en-aut-sei=Maeda en-aut-mei=Takanori kn-aut-name=前田孚憲 kn-aut-sei=前田 kn-aut-mei=孚憲 aut-affil-num=2 ORCID= en-aut-name=InouyeNarinobu en-aut-sei=Inouye en-aut-mei=Narinobu kn-aut-name=井上成信 kn-aut-sei=井上 kn-aut-mei=成信 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=1 article-no= start-page=1 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=197702 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Serological diagnosis methods for Cymbidum mosaic virus and Odontoglossum ringspot virus in orchids kn-title=抗血清を利用したCymbidium mosaic virusおよびOdontoglossum ringspot virusの診断法 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=InouyeN. en-aut-sei=Inouye en-aut-mei=N. kn-aut-name=井上成信 kn-aut-sei=井上 kn-aut-mei=成信 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=口腔小唾液腺腫瘍:診断おけるダイナミックMRIの有用性 kn-title=Minor salivary gland tumors in the oral cavity: Diagnostic value of dynamic contrast-enhanced MRI en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MatsuzakiHidenobu en-aut-sei=Matsuzaki en-aut-mei=Hidenobu kn-aut-name=松﨑秀信 kn-aut-sei=松﨑 kn-aut-mei=秀信 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=2 article-no= start-page=139 end-page=143 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of strangulated ileus caused by internal hernia through a defect in the broad ligament of the uterus kn-title=子宮広間膜裂孔ヘルニアによる絞扼性イレウスの１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 41-year-old woman was admitted to our hospital because of lower abdominal pain. She had no history of laparotomy. An abdominal CT scan at the time of admission indicated closed-loop intestinal obstruction of the small intestine within the pelvis and deviation of the uterus to the right. We diagnosed this as a strangulated internal hernia and decided to conduct an emergency operation. The ileum had herniated through a defect in the broad ligament of the uterus. The strangulated intestinal loop, which was about 25cm long, was released, and the defect of the broad ligament was closed. The postoperative course was uneventful. The differential diagnosis of intestinal obstruction should include internal hernia, especially in the absence of a previous laparotomy. An abdominal CT scan is quite useful for the preoperative and prompt diagnosis of internal hernia through a defect in the broad ligament of the uterus. en-copyright= kn-copyright= en-aut-name=HaisaMinoru en-aut-sei=Haisa en-aut-mei=Minoru kn-aut-name=羽井佐実 kn-aut-sei=羽井佐 kn-aut-mei=実 aut-affil-num=1 ORCID= en-aut-name=SakaiRyo en-aut-sei=Sakai en-aut-mei=Ryo kn-aut-name=酒井亮 kn-aut-sei=酒井 kn-aut-mei=亮 aut-affil-num=2 ORCID= en-aut-name=KuriharaEisuke en-aut-sei=Kurihara en-aut-mei=Eisuke kn-aut-name=栗原英祐 kn-aut-sei=栗原 kn-aut-mei=英祐 aut-affil-num=3 ORCID= en-aut-name=TeramotoAtsushi en-aut-sei=Teramoto en-aut-mei=Atsushi kn-aut-name=寺本淳 kn-aut-sei=寺本 kn-aut-mei=淳 aut-affil-num=4 ORCID= en-aut-name=ShougaKazuhiko en-aut-sei=Shouga en-aut-mei=Kazuhiko kn-aut-name=庄賀一彦 kn-aut-sei=庄賀 kn-aut-mei=一彦 aut-affil-num=5 ORCID= en-aut-name=MitsuokaShintarou en-aut-sei=Mitsuoka en-aut-mei=Shintarou kn-aut-name=光岡晋太郎 kn-aut-sei=光岡 kn-aut-mei=晋太郎 aut-affil-num=6 ORCID= en-aut-name=NishimuraMamoru en-aut-sei=Nishimura en-aut-mei=Mamoru kn-aut-name=西村守 kn-aut-sei=西村 kn-aut-mei=守 aut-affil-num=7 ORCID= en-aut-name=SatouYuuki en-aut-sei=Satou en-aut-mei=Yuuki kn-aut-name=佐藤雄紀 kn-aut-sei=佐藤 kn-aut-mei=雄紀 aut-affil-num=8 ORCID= en-aut-name=NanbaJiro en-aut-sei=Nanba en-aut-mei=Jiro kn-aut-name=難波次郎 kn-aut-sei=難波 kn-aut-mei=次郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山市立市民病院 消化器外科 affil-num=2 en-affil= kn-affil=岡山市立市民病院 消化器外科 affil-num=3 en-affil= kn-affil=岡山市立市民病院 消化器外科 affil-num=4 en-affil= kn-affil=岡山市立市民病院 消化器外科 affil-num=5 en-affil= kn-affil=岡山市立市民病院 消化器外科 affil-num=6 en-affil= kn-affil=岡山市立市民病院 消化器外科 affil-num=7 en-affil= kn-affil=岡山市立市民病院 消化器内科 affil-num=8 en-affil= kn-affil=岡山市立市民病院 消化器内科 affil-num=9 en-affil= kn-affil=岡山市立市民病院 消化器内科 en-keyword=子宮広間膜裂孔（broad ligament） kn-keyword=子宮広間膜裂孔（broad ligament） en-keyword=内ヘルニア（internal hernia） kn-keyword=内ヘルニア（internal hernia） en-keyword=絞扼性イレウス（strangulated ileus） kn-keyword=絞扼性イレウス（strangulated ileus） en-keyword=MDCT（multi-detector CT） kn-keyword=MDCT（multi-detector CT） END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=2 article-no= start-page=119 end-page=127 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The treatment strategy for clinical stage III non-small cell lung cancer kn-title=臨床病期Ⅲ期肺非小細胞癌に対する治療戦略 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KiuraKatsuyuki en-aut-sei=Kiura en-aut-mei=Katsuyuki kn-aut-name=木浦勝行 kn-aut-sei=木浦 kn-aut-mei=勝行 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院 呼吸器・アレルギー内科 en-keyword=concomitant chemoradiotherapy kn-keyword=concomitant chemoradiotherapy en-keyword=third generation kn-keyword=third generation en-keyword=surgery kn-keyword=surgery END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=2 article-no= start-page=113 end-page=117 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Pathological diagnosis of urothelial carcinoma kn-title=尿路上皮癌の病理診断―特に平坦病変について― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YanaiHiroyuki en-aut-sei=Yanai en-aut-mei=Hiroyuki kn-aut-name=柳井広之 kn-aut-sei=柳井 kn-aut-mei=広之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院 病理診断科 en-keyword=尿路上皮癌 kn-keyword=尿路上皮癌 en-keyword=尿路上皮異形成 kn-keyword=尿路上皮異形成 en-keyword=尿路上皮内癌 kn-keyword=尿路上皮内癌 END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=2 article-no= start-page=103 end-page=107 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B cell characteristics kn-title=十二指腸濾胞性リンパ腫はAIDの発現を欠くがBACH2の発現を有しmemoryB細胞としての性質を有する en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakataKatsuyoshi en-aut-sei=Takata en-aut-mei=Katsuyoshi kn-aut-name=高田尚良 kn-aut-sei=高田 kn-aut-mei=尚良 aut-affil-num=1 ORCID= en-aut-name=SatoYasuharu en-aut-sei=Sato en-aut-mei=Yasuharu kn-aut-name=佐藤康晴 kn-aut-sei=佐藤 kn-aut-mei=康晴 aut-affil-num=2 ORCID= en-aut-name=NakamuraNaoya en-aut-sei=Nakamura en-aut-mei=Naoya kn-aut-name=中村直哉 kn-aut-sei=中村 kn-aut-mei=直哉 aut-affil-num=3 ORCID= en-aut-name=TokunakaMami en-aut-sei=Tokunaka en-aut-mei=Mami kn-aut-name=徳中摩美 kn-aut-sei=徳中 kn-aut-mei=摩美 aut-affil-num=4 ORCID= en-aut-name=MikiYukari en-aut-sei=Miki en-aut-mei=Yukari kn-aut-name=三木由香里 kn-aut-sei=三木 kn-aut-mei=由香里 aut-affil-num=5 ORCID= en-aut-name=KikutiYara Yukie en-aut-sei=Kikuti en-aut-mei=Yara Yukie kn-aut-name=菊池イアーラ幸江 kn-aut-sei=菊池 kn-aut-mei=イアーラ幸江 aut-affil-num=6 ORCID= en-aut-name=IgarashiKazuhiko en-aut-sei=Igarashi en-aut-mei=Kazuhiko kn-aut-name=五十嵐和彦 kn-aut-sei=五十嵐 kn-aut-mei=和彦 aut-affil-num=7 ORCID= en-aut-name=ItoEtsuro en-aut-sei=Ito en-aut-mei=Etsuro kn-aut-name=伊藤悦郎 kn-aut-sei=伊藤 kn-aut-mei=悦郎 aut-affil-num=8 ORCID= en-aut-name=HarigaeHideo en-aut-sei=Harigae en-aut-mei=Hideo kn-aut-name=張替秀雄 kn-aut-sei=張替 kn-aut-mei=秀雄 aut-affil-num=9 ORCID= en-aut-name=KatoSeiichi en-aut-sei=Kato en-aut-mei=Seiichi kn-aut-name=加藤省一 kn-aut-sei=加藤 kn-aut-mei=省一 aut-affil-num=10 ORCID= en-aut-name=HayashiEiko en-aut-sei=Hayashi en-aut-mei=Eiko kn-aut-name=林詠子 kn-aut-sei=林 kn-aut-mei=詠子 aut-affil-num=11 ORCID= en-aut-name=OkaTakashi en-aut-sei=Oka en-aut-mei=Takashi kn-aut-name=岡剛史 kn-aut-sei=岡 kn-aut-mei=剛史 aut-affil-num=12 ORCID= en-aut-name=HoshiiYoshinobu en-aut-sei=Hoshii en-aut-mei=Yoshinobu kn-aut-name=星井嘉信 kn-aut-sei=星井 kn-aut-mei=嘉信 aut-affil-num=13 ORCID= en-aut-name=TariAkira en-aut-sei=Tari en-aut-mei=Akira kn-aut-name=田利晶 kn-aut-sei=田利 kn-aut-mei=晶 aut-affil-num=14 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=15 ORCID= en-aut-name=MohamadoABD Alkader Lamia en-aut-sei=Mohamado en-aut-mei=ABD Alkader Lamia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name=前田嘉信 kn-aut-sei=前田 kn-aut-mei=嘉信 aut-affil-num=17 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name=谷本光音 kn-aut-sei=谷本 kn-aut-mei=光音 aut-affil-num=18 ORCID= en-aut-name=KinoshitaTomohiro en-aut-sei=Kinoshita en-aut-mei=Tomohiro kn-aut-name=木下朝博 kn-aut-sei=木下 kn-aut-mei=朝博 aut-affil-num=19 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name=吉野正 kn-aut-sei=吉野 kn-aut-mei=正 aut-affil-num=20 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理） affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科病理学（腫瘍病理） affil-num=3 en-affil= kn-affil=東海大学医学部　病理診断学講座 affil-num=4 en-affil= kn-affil=東海大学医学部　病理診断学講座 affil-num=5 en-affil= kn-affil=香川保健医療短期大学 affil-num=6 en-affil= kn-affil=東海大学医学部　病理診断学講座 affil-num=7 en-affil= kn-affil=東北大学大学院医学系研究科 生物化学分野 affil-num=8 en-affil= kn-affil=弘前大学医学部　小児科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・免疫病学分野 affil-num=10 en-affil= kn-affil=名古屋大学病院　病理部 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理） affil-num=12 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理） affil-num=13 en-affil= kn-affil=山口大学医学部　病理学 affil-num=14 en-affil= kn-affil=広島赤十字・原爆病院　消化器内科 affil-num=15 en-affil= kn-affil=岡山大学病院　光学診療部 affil-num=16 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理） affil-num=17 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科血液・腫瘍・呼吸器内科学 affil-num=18 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科血液・腫瘍・呼吸器内科学 affil-num=19 en-affil= kn-affil=愛知がんセンター　血液細胞療法部 affil-num=20 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理） en-keyword=follicular lymphoma kn-keyword=follicular lymphoma en-keyword=gastrointestinal tract kn-keyword=gastrointestinal tract en-keyword=BACH2 kn-keyword=BACH2 en-keyword=memory B cell kn-keyword=memory B cell END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=膵癌診療における造影PET/CTの有用性（鑑別診断、進展度評価、治療効果判定と再発診断) kn-title=Utility of Contrast-Enhanced FDG-PET/CT in the Clinical Management of Pancreatic Cancer: Impact on Diagnosis, Staging, Evaluation of Treatment Response, and Detection of Recurrence en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AsagiAkinori en-aut-sei=Asagi en-aut-mei=Akinori kn-aut-name=浅木彰則 kn-aut-sei=浅木 kn-aut-mei=彰則 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=1 article-no= start-page=69 end-page=71 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Guidelines for the treatment of Parkinson’s disease kn-title=パーキンソン病の治療ガイドライン en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KurataTomoko en-aut-sei=Kurata en-aut-mei=Tomoko kn-aut-name=倉田智子 kn-aut-sei=倉田 kn-aut-mei=智子 aut-affil-num=1 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name=阿部康二 kn-aut-sei=阿部 kn-aut-mei=康二 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　神経内科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経内科学 END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=1 article-no= start-page=35 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An epidemiologically rare case of Vibrio vulnificus infection that occurred in October in an inland city of Japan kn-title=内陸地津山で発症した季節外れのVibrio vulnificus感染症 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 68-year-old man with alcohol addiction, who lived in the suburbs of Tsuyama, an inland city located in northeast Okayama prefecture, was transported to the emergency unit of the Tsuyama Central Hospital in a state of cardiopulmonary arrest (CPA). Despite rigorous systemic investigation and treatment, the patient died 2 hours after arrival. After his death, Vibrio vulnificus was isolated from his blood culture. 　Vibrio vulnificus causes fatal infection in humans, usually only in areas located close to the sea where appropriate temperature and suitable salt concentration for its growth are available. Therefore, its occurrence is epidemiologically restricted ; in Japan, the western coastal areas, especially in summers, are reported to be the high-risk regions. This is a rare case because it occurred in a city approximately 50 kilometers from both the Sea of Japan and the Pacific coast of Okayama, and at the end of October in 2011. Economic development and distribution systems have made it possible to transport various food products from coastal areas or abroad to any place in a short time, such that these infections can potentially develop in areas other than expected. We should be aware of the increasing risk of Vibrio vulnificus infection during any season and at any place, especially in patients with abnormal liver function. en-copyright= kn-copyright= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name=萩谷英大 kn-aut-sei=萩谷 kn-aut-mei=英大 aut-affil-num=1 ORCID= en-aut-name=ShiotaSumiko en-aut-sei=Shiota en-aut-mei=Sumiko kn-aut-name=塩田澄子 kn-aut-sei=塩田 kn-aut-mei=澄子 aut-affil-num=2 ORCID= en-aut-name=MiyoshiShin-ichi en-aut-sei=Miyoshi en-aut-mei=Shin-ichi kn-aut-name=三好伸一 kn-aut-sei=三好 kn-aut-mei=伸一 aut-affil-num=3 ORCID= en-aut-name=KuroeYasutoshi en-aut-sei=Kuroe en-aut-mei=Yasutoshi kn-aut-name=黒江泰利 kn-aut-sei=黒江 kn-aut-mei=泰利 aut-affil-num=4 ORCID= en-aut-name=NojimaHiroyoshi en-aut-sei=Nojima en-aut-mei=Hiroyoshi kn-aut-name=野島宏悦 kn-aut-sei=野島 kn-aut-mei=宏悦 aut-affil-num=5 ORCID= en-aut-name=OtaniShinkichi en-aut-sei=Otani en-aut-mei=Shinkichi kn-aut-name=大谷晋吉 kn-aut-sei=大谷 kn-aut-mei=晋吉 aut-affil-num=6 ORCID= en-aut-name=SugiyamaJunichi en-aut-sei=Sugiyama en-aut-mei=Junichi kn-aut-name=杉山淳一 kn-aut-sei=杉山 kn-aut-mei=淳一 aut-affil-num=7 ORCID= en-aut-name=NaitoHiromichi en-aut-sei=Naito en-aut-mei=Hiromichi kn-aut-name=内藤宏道 kn-aut-sei=内藤 kn-aut-mei=宏道 aut-affil-num=8 ORCID= en-aut-name=KawanishiSusumu en-aut-sei=Kawanishi en-aut-mei=Susumu kn-aut-name=川西進 kn-aut-sei=川西 kn-aut-mei=進 aut-affil-num=9 ORCID= en-aut-name=HagiokaShingo en-aut-sei=Hagioka en-aut-mei=Shingo kn-aut-name=萩岡信吾 kn-aut-sei=萩岡 kn-aut-mei=信吾 aut-affil-num=10 ORCID= en-aut-name=MorimotoNaoki en-aut-sei=Morimoto en-aut-mei=Naoki kn-aut-name=森本直樹 kn-aut-sei=森本 kn-aut-mei=直樹 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=2 en-affil= kn-affil=就実大学薬学部　病原微生物学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　衛生微生物化学 affil-num=4 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=5 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=6 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=7 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=8 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=9 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=10 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=11 en-affil= kn-affil=津山中央病院　救命救急センター en-keyword=Vibrio vulnificus kn-keyword=Vibrio vulnificus END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue= article-no= start-page=21 end-page=28 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Incidence of Blossom-end Rot in Relation to Water-soluble Ca Concentration in Tomato Fruits as Affected by Ca Nutrition under Root Restriction kn-title=培養液中Ca濃度が根域制限栽培したトマト果実の 水溶性Ca濃度と尻腐れ果発生に及ぼす影響 en-subtitle= kn-subtitle= en-abstract=根域制限下におけるトマトの養分吸収を調査した結果，培養液中Caの多くは排液とともに排出され，Ｎに対するCaの吸収比率は園試処方やHoagland処方中の比率の50%以下であった．そこで，園試処方培養液中のCa(NO3)2･4H2Oの一部をNH4NO3に置換してCa濃度１，２，４ﾋの培養液を作成し，日射比例給液制御下で ‘ハウス桃太郎’の根城制限栽培（培地容量250，500 ㎖）を行った．培養液のCa濃度が１ﾋであっても排液中のCa濃度が２ﾋよりも高く推移したが，Ca吸収量は極めて少なく，著しいCa欠乏症状が現れた．低Ca濃度区では尻腐れ果が多発し，１ﾋ区では第３果房より上段の果実は全て尻腐れ果となり，第９果房までの収量は２ﾋ区，１ﾋ区でそれぞれ４ﾋ区の50%，36%に低下した．腋芽茎中のCa濃度の低下は0.6N-NaCl可溶性画分や0.6N-HCl可溶性画分と比較して水溶性画分の低下が著しかった．そこで，Ca濃度が１～４ﾋの培養液を用いて点滴栽培を行い，果実中のCa濃度を分画して定量した．果実頂部のCa濃度はいずれの画分においても培養液中Ca濃度が低いほど低く，開花から尻腐れ症状が発生するまでの日数も短くなった．尻腐れ果発生率と果頂部の水溶性Ca濃度との間にのみ有意な負の相関が認められた．以上のことから，果実の水溶性Ca濃度がトマトの尻腐れ果発生リスクの大小に大きくかかわっており，植物体の水溶性Ca濃度測定は尻腐れ果発生防止のためのCa栄養診断に応用できる可能性が高いと考えられる． kn-abstract=The rate of absorbed Ca to N was less than half of Enshi or Hoagland solution in tomato (Solanum lycopersicum Mill.) grown with restricted root zone volume in previous experiments. Tomato plants were grown in plastic pots containing 250 or 500ml of peat based medium with modified Enshi solutions containing 1, 2 or 4mM of Ca. The solutions were prepared by replacing a part of Ca(NO3)2・4H2O to NH4NO3. Although Ca concentration was higher than 2mM in drainage collected from plants supplied 1mM Ca solution, absorbed amount of Ca was very small and severe symptom of Ca deficiency was observed. Incidence of blossom-end rot (BER) increased with decrease in Ca concentration of the solution and yield decreased to 50% and 36% of 4mM control, in 2mM and 1mM plots, respectively. Among fractionated Ca in stem of lateral shoot, decrease in water-soluble fraction was remarkable compared to 1N NaCl- or 0.6N HCl-soluble fractions. Tomato plants were then grown with modified solutions containing 1~4mM of Ca and fractionated Ca was determined for distal half of fruits. With decrease in solution Ca, fruit Ca decreased in all fractions, and days to BER incidence after flowering also decreased. Significant relationship was found only between the water-soluble Ca concentration in fruit tissue and rate of BER incidence. Thus water-soluble Ca in tomato fruit may closely relate to BER incidence, and an efficient tool to estimate the potential risk of BER may possibly be developed by determining the Ca fraction in the stem of lateral shoots. en-copyright= kn-copyright= en-aut-name=YoshidaYuichi en-aut-sei=Yoshida en-aut-mei=Yuichi kn-aut-name=吉田裕一 kn-aut-sei=吉田 kn-aut-mei=裕一 aut-affil-num=1 ORCID= en-aut-name=ShingaiAya en-aut-sei=Shingai en-aut-mei=Aya kn-aut-name=新開礼 kn-aut-sei=新開 kn-aut-mei=礼 aut-affil-num=2 ORCID= en-aut-name=OoyamaMitsuo en-aut-sei=Ooyama en-aut-mei=Mitsuo kn-aut-name=大山光男 kn-aut-sei=大山 kn-aut-mei=光男 aut-affil-num=3 ORCID= en-aut-name=MurakamiKenji en-aut-sei=Murakami en-aut-mei=Kenji kn-aut-name=村上賢治 kn-aut-sei=村上 kn-aut-mei=賢治 aut-affil-num=4 ORCID= en-aut-name=GotoTanjuro en-aut-sei=Goto en-aut-mei=Tanjuro kn-aut-name=後藤丹十郎 kn-aut-sei=後藤 kn-aut-mei=丹十郎 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=岡山大学 en-keyword=BER kn-keyword=BER en-keyword=Ca absorption kn-keyword=Ca absorption en-keyword=Ca fractions kn-keyword=Ca fractions en-keyword=dripfertigation kn-keyword=dripfertigation en-keyword=Enshi solution kn-keyword=Enshi solution END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=3 article-no= start-page=255 end-page=257 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20121203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Features and management of pediatric infectious disease kn-title=小児科領域における感染症 その特性と治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MiyamuraTakako en-aut-sei=Miyamura en-aut-mei=Takako kn-aut-name=宮村能子 kn-aut-sei=宮村 kn-aut-mei=能子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=大阪大学大学院医学系研究科　小児科学 END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=3 article-no= start-page=253 end-page=254 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20121203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Guidelines for clinical use of anticoagulant and antiplatelet therapy in cardiovascular disease kn-title=循環器疾患における抗凝固・抗血小板療法 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MiyoshiToru en-aut-sei=Miyoshi en-aut-mei=Toru kn-aut-name=三好亨 kn-aut-sei=三好 kn-aut-mei=亨 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　先端循環器治療学 END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=3 article-no= start-page=243 end-page=247 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20121203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of intracystic carcinoma of the breast showing pathological complete response by neoadjuvant chemotherapy kn-title=術前化学療法により壁が菲薄化し組織学的寛解（pCR）となった巨大嚢胞内乳癌の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 31-year-old woman presented to our hospital because of a lump 5cm in diameter in her right breast. Ultrasonography revealed a multilocular cystic mass with partial thickening of the wall and the septum. Core needle biopsy (CNB) of the septum confirmed invasive ductal carcinoma. The patient was administered neoadjuvant chemotherapy consisting of 12 cycles of weekly paclitaxel followed by 4 cycles of FEC (5FU, Epilubicin and cyclophosphamide). While the thickness of the wall and septum became thinner, the tumor size did not change in diameter. She underwent right mastectomy and sentinel node biopsy. Post-surgical histopathological findings showed a pathological complete response (pCR).
　We report a rare case of invasive ductal carcinoma presenting a multilobular phenotype which showed pCR by neoadjuvant chemotherapy despite no size reduction of the tumor. en-copyright= kn-copyright= en-aut-name=ImadaTakako en-aut-sei=Imada en-aut-mei=Takako kn-aut-name=今田孝子 kn-aut-sei=今田 kn-aut-mei=孝子 aut-affil-num=1 ORCID= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=2 ORCID= en-aut-name=MotokiTakayuki en-aut-sei=Motoki en-aut-mei=Takayuki kn-aut-name=元木崇之 kn-aut-sei=元木 kn-aut-mei=崇之 aut-affil-num=3 ORCID= en-aut-name=IwamotoTakayuki en-aut-sei=Iwamoto en-aut-mei=Takayuki kn-aut-name=岩本高行 kn-aut-sei=岩本 kn-aut-mei=高行 aut-affil-num=4 ORCID= en-aut-name=OomoriMasako en-aut-sei=Oomori en-aut-mei=Masako kn-aut-name=大森昌子 kn-aut-sei=大森 kn-aut-mei=昌子 aut-affil-num=5 ORCID= en-aut-name=IhaSigemichi en-aut-sei=Iha en-aut-mei=Sigemichi kn-aut-name=伊波茂道 kn-aut-sei=伊波 kn-aut-mei=茂道 aut-affil-num=6 ORCID= en-aut-name=HongoToshie en-aut-sei=Hongo en-aut-mei=Toshie kn-aut-name=本後登志江 kn-aut-sei=本後 kn-aut-mei=登志江 aut-affil-num=7 ORCID= en-aut-name=HenmiNoriko en-aut-sei=Henmi en-aut-mei=Noriko kn-aut-name=逸見典子 kn-aut-sei=逸見 kn-aut-mei=典子 aut-affil-num=8 ORCID= en-aut-name=MakabeMikio en-aut-sei=Makabe en-aut-mei=Mikio kn-aut-name=真壁幹夫 kn-aut-sei=真壁 kn-aut-mei=幹夫 aut-affil-num=9 ORCID= en-aut-name=NogamiHiromi en-aut-sei=Nogami en-aut-mei=Hiromi kn-aut-name=野上浩實 kn-aut-sei=野上 kn-aut-mei=浩實 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=5 en-affil= kn-affil=岡山大学病院　病理診断科 affil-num=6 en-affil= kn-affil=岡山大福クリニック affil-num=7 en-affil= kn-affil=岡山大福クリニック affil-num=8 en-affil= kn-affil=岡山大福クリニック affil-num=9 en-affil= kn-affil=岡山中央病院 affil-num=10 en-affil= kn-affil=野上病院 en-keyword=嚢胞内乳癌（intracystic breast cancer） kn-keyword=嚢胞内乳癌（intracystic breast cancer） en-keyword=術前化学療法（neoadjuvant chemotherapy） kn-keyword=術前化学療法（neoadjuvant chemotherapy） en-keyword=組織学的完全奏功（pahthological CR） kn-keyword=組織学的完全奏功（pahthological CR） END start-ver=1.4 cd-journal=joma no-vol=97 cd-vols= no-issue=6 article-no= start-page=326 end-page=333 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Methods of Diagnosis and Intervention for Agent of Hot Rolling Operation Support kn-title=熱延操業支援エージェント構築のための操業診断と圧延操作方法 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the last two decades, it becomes possible to automate operations of various steel plants especially in rolling mills. As the results, stabilization of productivity and improvement of product quality have been attained. On the while, in these years, many skilled engineers and operators who actively promoted economical growth of steel industries will retire due to their age limits. Thus, the inheritance of the high level technology and know-how has becomes a serious problem. To overcome the problem, it is necessary to extract knowledge of the skilled persons and make technical textbook reducing tacit knowledge. In this paper, rules are extracted from the operation data of hot strip rolling applicable to the operation diagnosis and intervention during operation. To attain the object, agent based simulator of hot strip rolling has been developed to prepare various rolling data for extraction of diagnosis and intervention rules in rolling operations. As for the selection of normal and abnormal data, SVM algorithm is tested before rules extraction. Rules are written in Fuzzy logic forms and its parameters are optimized by GA algorithm. These technologies are involved in the operation support agent system of hot strip rolling mills together with RNN for automatic gain tuning of mill controller. en-copyright= kn-copyright= en-aut-name=KonishiMasami en-aut-sei=Konishi en-aut-mei=Masami kn-aut-name=小西正躬 kn-aut-sei=小西 kn-aut-mei=正躬 aut-affil-num=1 ORCID= en-aut-name=NakanoKoichi en-aut-sei=Nakano en-aut-mei=Koichi kn-aut-name=中野孝一 kn-aut-sei=中野 kn-aut-mei=孝一 aut-affil-num=2 ORCID= en-aut-name=ImaiJun en-aut-sei=Imai en-aut-mei=Jun kn-aut-name=今井純 kn-aut-sei=今井 kn-aut-mei=純 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院自然科学研究科 affil-num=2 en-affil= kn-affil=岡山大学大学院自然科学研究科 affil-num=3 en-affil= kn-affil=岡山大学大学院自然科学研究科 en-keyword=diagnosis kn-keyword=diagnosis en-keyword=agent system kn-keyword=agent system en-keyword=human intervention kn-keyword=human intervention en-keyword=hot strip rolling kn-keyword=hot strip rolling en-keyword=rule extraction kn-keyword=rule extraction en-keyword=genetic algorithm kn-keyword=genetic algorithm en-keyword=support vector machine kn-keyword=support vector machine END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=2 article-no= start-page=161 end-page=163 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Guidelines for diagnosis and treatment of syncope kn-title=失神の診断と治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NishiiNobuhiro en-aut-sei=Nishii en-aut-mei=Nobuhiro kn-aut-name=西井伸洋 kn-aut-sei=西井 kn-aut-mei=伸洋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　循環器内科 END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=2 article-no= start-page=155 end-page=159 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Approaches for infantile hearing loss：Transmission from Okayama to other prefectures kn-title=小児難聴に対する取り組み―岡山から全国への発信― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaYuko en-aut-sei=Kataoka en-aut-mei=Yuko kn-aut-name=片岡祐子 kn-aut-sei=片岡 kn-aut-mei=祐子 aut-affil-num=1 ORCID= en-aut-name=FukushimaKunihiro en-aut-sei=Fukushima en-aut-mei=Kunihiro kn-aut-name=福島邦博 kn-aut-sei=福島 kn-aut-mei=邦博 aut-affil-num=2 ORCID= en-aut-name=SugayaAkiko en-aut-sei=Sugaya en-aut-mei=Akiko kn-aut-name=菅谷明子 kn-aut-sei=菅谷 kn-aut-mei=明子 aut-affil-num=3 ORCID= en-aut-name=NishizakiKazunori en-aut-sei=Nishizaki en-aut-mei=Kazunori kn-aut-name=西﨑和則 kn-aut-sei=西﨑 kn-aut-mei=和則 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　耳鼻咽喉・頭頸部外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　耳鼻咽喉・頭頸部外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　耳鼻咽喉・頭頸部外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　耳鼻咽喉・頭頸部外科学 en-keyword=新生児聴覚スクリーニング検査 kn-keyword=新生児聴覚スクリーニング検査 en-keyword=小児難聴 kn-keyword=小児難聴 en-keyword=補聴器・人工内耳 kn-keyword=補聴器・人工内耳 en-keyword=言語発達 kn-keyword=言語発達 en-keyword=遺伝子診断 kn-keyword=遺伝子診断 END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=2 article-no= start-page=149 end-page=153 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of strangulated ileus caused by transomental hernia with reference to previously reported cases kn-title=術前診断し得た大網裂孔ヘルニアの一例―本邦報告203例の臨床病理学的検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Transomental hernia often develops into strangulated ileus. We report on an 81-year-old man with strangulated ileus due to transomental hernia, diagnosed preoperatively by abdominal CT. The patient was referred to our surgical division because of progressive abdominal pain and vomiting. He had no history of laparotomy. An abdominal CT scan showed dilated small intestinal loops with intraluminal air and strangulated small intestinal loops with engorged mesenteric vessels. We diagnosed this as a strangulated internal hernia due to transomental hernia and conducted an emergency laparotomy. The jejunum had herniated through an abnormal hiatus of the greater omentum to the peritoneal cavity. The strangulated intestinal loop, about 15 cm long, was released and the postoperative course was uneventful. In the absence of a previous laparotomy, the differential diagnosis of intestinal obstruction should include internal hernia. An abdominal CT scan is useful for the preoperative and prompt diagnosis of transomental hernia. en-copyright= kn-copyright= en-aut-name=KimuraYuji en-aut-sei=Kimura en-aut-mei=Yuji kn-aut-name=木村裕司 kn-aut-sei=木村 kn-aut-mei=裕司 aut-affil-num=1 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=岩川和秀 kn-aut-sei=岩川 kn-aut-mei=和秀 aut-affil-num=2 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=3 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=稲垣優 kn-aut-sei=稲垣 kn-aut-mei=優 aut-affil-num=4 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=4 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=5 en-affil= kn-affil=国立病院機構福山医療センター　外科 en-keyword=大網裂孔ヘルニア（transomental hernia） kn-keyword=大網裂孔ヘルニア（transomental hernia） en-keyword=絞扼性イレウス（strangulated ileus） kn-keyword=絞扼性イレウス（strangulated ileus） END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=2 article-no= start-page=145 end-page=148 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of esophageal carcinosarcoma with a component of small cell carcinoma kn-title=小細胞癌成分を含む食道癌肉腫の１切除例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We experienced a case of esophageal carcinosarcoma with a component of small cell carcinoma. The patient was a 73-year-old man. We administered chemotherapy of CDDP+VP-16, and performed an operation after 2 courses of this chemotherapy. Subtotal esophagectomy and reconstruction with the small intestine was performed. More than three years after resection, he remains alive and recurrence-free. There are few cases of esophageal carcinosarcoma and small cell carcinoma. We report this rare case herein. en-copyright= kn-copyright= en-aut-name=TanabeShunsuke en-aut-sei=Tanabe en-aut-mei=Shunsuke kn-aut-name=田辺俊介 kn-aut-sei=田辺 kn-aut-mei=俊介 aut-affil-num=1 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name=白川靖博 kn-aut-sei=白川 kn-aut-mei=靖博 aut-affil-num=2 ORCID= en-aut-name=MaedaNaoaki en-aut-sei=Maeda en-aut-mei=Naoaki kn-aut-name=前田直見 kn-aut-sei=前田 kn-aut-mei=直見 aut-affil-num=3 ORCID= en-aut-name=OharaToshiaki en-aut-sei=Ohara en-aut-mei=Toshiaki kn-aut-name=大原利章 kn-aut-sei=大原 kn-aut-mei=利章 aut-affil-num=4 ORCID= en-aut-name=NomaKazuhiro en-aut-sei=Noma en-aut-mei=Kazuhiro kn-aut-name=野間和広 kn-aut-sei=野間 kn-aut-mei=和広 aut-affil-num=5 ORCID= en-aut-name=SakuramaKazufumi en-aut-sei=Sakurama en-aut-mei=Kazufumi kn-aut-name=櫻間教文 kn-aut-sei=櫻間 kn-aut-mei=教文 aut-affil-num=6 ORCID= en-aut-name=YanaiHiroyuki en-aut-sei=Yanai en-aut-mei=Hiroyuki kn-aut-name=柳井広之 kn-aut-sei=柳井 kn-aut-mei=広之 aut-affil-num=7 ORCID= en-aut-name=YamatsujiTomoki en-aut-sei=Yamatsuji en-aut-mei=Tomoki kn-aut-name=山辻知樹 kn-aut-sei=山辻 kn-aut-mei=知樹 aut-affil-num=8 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=9 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=2 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=3 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=4 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=5 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=6 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=7 en-affil= kn-affil=岡山大学病院　病理診断科 affil-num=8 en-affil= kn-affil=川崎医科大学　総合外科学 affil-num=9 en-affil= kn-affil=川崎医科大学　総合外科学 affil-num=10 en-affil= kn-affil=岡山大学病院　消化管外科 en-keyword=食道癌肉腫（esophageal carcinosarcoma） kn-keyword=食道癌肉腫（esophageal carcinosarcoma） en-keyword=小細胞癌（small cell carcinoma） kn-keyword=小細胞癌（small cell carcinoma） en-keyword=食道（esophagus） kn-keyword=食道（esophagus） END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=自動的なコンピューター化された１２誘導心電図による左室肥大診断におけるQT dispersionの診断的意義：日本人を対象として kn-title=QT Dispersion Measured by Automatic Computerized 12-lead Electrocardiography Contributes Significantly to Detection of Left Ventricular Hypertrophy in Japanese Patients en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IzumiReiji en-aut-sei=Izumi en-aut-mei=Reiji kn-aut-name=泉礼司 kn-aut-sei=泉 kn-aut-mei=礼司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=悪性胸膜中皮腫の鑑別診断における胸水中の異常DNAメチル化の解析結果 kn-title=Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FujiiMasanori en-aut-sei=Fujii en-aut-mei=Masanori kn-aut-name=藤井昌学 kn-aut-sei=藤井 kn-aut-mei=昌学 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=病変全体がすりガラス陰影を呈する限局性肺病変のCT透視下針生検：83病変での診断率 kn-title=CT fluoroscopy-guided cutting needle biopsy of focal pure ground-glass opacity lung lesions: Diagnostic yield in 83 lesions en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=InoueDaisaku en-aut-sei=Inoue en-aut-mei=Daisaku kn-aut-name=井上大作 kn-aut-sei=井上 kn-aut-mei=大作 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue=4 article-no= start-page=276 end-page=281 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199507 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=視覚情報処理機能の発達とP300の加齢変化の過程 en-subtitle= kn-subtitle= en-abstract= kn-abstract=5-25歳の健常児･者72名を対象に, 三種の弁別課題条件下でP300潜時の加齢変化 の過程を比較した.P300潜時は14歳頃までに急速な短縮を示したが, その短縮速度は課題間 で異なっていた.5-14歳の年間平均短縮速度は,単語弁別の左右釦押し反応を求めた場合17 ms,go-nogo反応では16msであったのに対し, 色弁別の左右選択反応課題では28msであっ た.潜時がもっとも短縮する年齢を二次回帰式から予測すると,単語課題が26歳(28歳)に対 し, 色課題では19歳と5年以上の開きが認められた.加齢に伴う潜時の変化は提示課題によっ て異なることを指摘するとともに, この変化には刺激処理機構の発達が表現されることを考察し た. en-copyright= kn-copyright= en-aut-name=YanagiharaMasafumi en-aut-sei=Yanagihara en-aut-mei=Masafumi kn-aut-name=柳原正文 kn-aut-sei=柳原 kn-aut-mei=正文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=事象関連電位 kn-keyword=事象関連電位 en-keyword=P300 kn-keyword=P300 en-keyword=加齢変化 kn-keyword=加齢変化 en-keyword=発達診断 kn-keyword=発達診断 END start-ver=1.4 cd-journal=joma no-vol=36 cd-vols= no-issue=5 article-no= start-page=1197 end-page=1204 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=頚髄症のシネMRI en-subtitle= kn-subtitle= en-abstract= kn-abstract=シネMRIを用いた新しい動的画像診断法により頚 髄症46例の術前術後を評価し,脳脊髄液流無信号領域 (以下CSFflowvoid)を5つのタイプに分類した. 頚髄症の術前46例全例に,正常のCSFaowvoldが 認められなかったが,脊髄除圧後全例にCSFflow voidが認められ,仝例心電図上のR波から150-300 msecの心収縮期であった. 術後のCSFflowvoidのタイプは,手術方法,疾患 および術後の頚椎アライメントとの関連が認められた また,術後のCSFaowvoldのタイプと術後成績との 関係では,posteriortypeが最も良く,anteroposteriortype が最も悪く,それらの間に有意差を認めた. 本法は脊髄-の圧迫の程度をより的確にかつ動的に 表現した新しい方法であり,また非侵襲的な検査であ るので術後の除圧効果の評価法として有用である. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=浮田泰孝 kn-aut-sei=浮田 kn-aut-mei=泰孝 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Cervical myelopathy kn-keyword=Cervical myelopathy en-keyword=Magnetic resonance imaging kn-keyword=Magnetic resonance imaging en-keyword=Cerebrospinal fluid kn-keyword=Cerebrospinal fluid END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=1 article-no= start-page=71 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Guidelines for treatment of chronic heart failure kn-title=慢性心不全治療ガイドライン en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakamuraKazufumi en-aut-sei=Nakamura en-aut-mei=Kazufumi kn-aut-name=中村一文 kn-aut-sei=中村 kn-aut-mei=一文 aut-affil-num=1 ORCID= en-aut-name=ItoHiroshi en-aut-sei=Ito en-aut-mei=Hiroshi kn-aut-name=伊藤浩 kn-aut-sei=伊藤 kn-aut-mei=浩 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　循環器内科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　循環器内科学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=食道癌治療とくにリンパ節転移診断における，PET/CTによる画像診断と腫瘍増殖能をはじめとする組織学的診断との関連 kn-title=F-18 FDG-PET/CT Contributes to More Accurate Detection of Lymph Nodal Metastasis From Actively Proliferating Esophageal Squamous Cell Carcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TanabeShunsuke en-aut-sei=Tanabe en-aut-mei=Shunsuke kn-aut-name=田邊俊介 kn-aut-sei=田邊 kn-aut-mei=俊介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=3 article-no= start-page=243 end-page=245 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Gestational diabetes mellitus kn-title=妊娠糖尿病 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HiramatsuYuji en-aut-sei=Hiramatsu en-aut-mei=Yuji kn-aut-name=平松祐司 kn-aut-sei=平松 kn-aut-mei=祐司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　産科・婦人科学 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=3 article-no= start-page=217 end-page=219 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=FDG-PET/CT is useful in the diagnosis of early phase Takayasu's arteritis : A case report kn-title=FDG-PET/CTが診断に有用であった大動脈炎症候群の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 60-year-old female patient was admitted to our hospital in April, 2010 because of low-grade fever and malaise for several months. Physical examination on admission revealed no abnormalities except for a body temperature of 37.2℃. Blood examinations showed moderate anemia and a high erythrocyte sedimentation rate. There were no other specific abnormal findings. A systemic CT scan study disclosed diffuse thickening of the artery wall through the ascending, descending and abdominal aorta to the bilateral iliac arteries. In order to evaluate the quality of the vessel lesions, a FDG-PET/CT study was performed and revealed abnormal accumulation of 18F-FDG in the thickened wall, suggesting an inflammatory process in the lesion. Taking all these findings into consideration, we made the diagnosis of Takayasu's arteritis, and treated the patient with prednisolone. The treatment was effective and her symptoms improved. A later CT scan revealed that the artery wall became somewhat thinner. Takayasu's arteritis is a disease whose diagnosis is difficult to make because there are neither specific signs nor diagnostic laboratory findings in its early stage. We found that FDG-PET/CT was helpful in the diagnosis and evaluation of lesions in a patient with Takayasu's arteritis. en-copyright= kn-copyright= en-aut-name=NishiiKazuya en-aut-sei=Nishii en-aut-mei=Kazuya kn-aut-name=西井和也 kn-aut-sei=西井 kn-aut-mei=和也 aut-affil-num=1 ORCID= en-aut-name=ShigematsuTerunobu en-aut-sei=Shigematsu en-aut-mei=Terunobu kn-aut-name=重松照伸 kn-aut-sei=重松 kn-aut-mei=照伸 aut-affil-num=2 ORCID= en-aut-name=FujiiSoichiro en-aut-sei=Fujii en-aut-mei=Soichiro kn-aut-name=藤井総一郎 kn-aut-sei=藤井 kn-aut-mei=総一郎 aut-affil-num=3 ORCID= en-aut-name=MiyashitaKatsuhiro en-aut-sei=Miyashita en-aut-mei=Katsuhiro kn-aut-name=宮下雄博 kn-aut-sei=宮下 kn-aut-mei=雄博 aut-affil-num=4 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=5 ORCID= en-aut-name=SasakiMotofumi en-aut-sei=Sasaki en-aut-mei=Motofumi kn-aut-name=佐々木基史 kn-aut-sei=佐々木 kn-aut-mei=基史 aut-affil-num=6 ORCID= en-aut-name=HayakawaNobuhiko en-aut-sei=Hayakawa en-aut-mei=Nobuhiko kn-aut-name=早川信彦 kn-aut-sei=早川 kn-aut-mei=信彦 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山赤十字病院　総合内科 affil-num=2 en-affil= kn-affil=岡山赤十字病院　総合内科 affil-num=3 en-affil= kn-affil=岡山赤十字病院　総合内科 affil-num=4 en-affil= kn-affil=岡山赤十字病院　総合内科 affil-num=5 en-affil= kn-affil=岡山赤十字病院　総合内科 affil-num=6 en-affil= kn-affil=岡山赤十字病院　糖尿病・内分泌内科 affil-num=7 en-affil= kn-affil=岡山赤十字病院　糖尿病・内分泌内科 en-keyword=FDG-PET/CT kn-keyword=FDG-PET/CT en-keyword=大動脈炎症候群 (arteritis syndrome) kn-keyword=大動脈炎症候群 (arteritis syndrome) en-keyword=Takayasu's arteritis kn-keyword=Takayasu's arteritis END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=タリウムシンチグラフィーは、良性軟部腫瘍と悪性軟部腫瘍を鑑別するための有効な画像診断である kn-title=Thallium-201 Scintigraphy is an Effective Diagnostic Modality to Distinguish Malignant from Benign Soft Tissue Tumors en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KawakamiNaoaki en-aut-sei=Kawakami en-aut-mei=Naoaki kn-aut-name=川上直明 kn-aut-sei=川上 kn-aut-mei=直明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=2 article-no= start-page=141 end-page=144 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Japanese guideline for management of lateral epicondylitis kn-title=上腕骨外側上顆炎の診療ガイドライン en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ShimamuraYasunori en-aut-sei=Shimamura en-aut-mei=Yasunori kn-aut-name=島村安則 kn-aut-sei=島村 kn-aut-mei=安則 aut-affil-num=1 ORCID= en-aut-name=InoueMadoka en-aut-sei=Inoue en-aut-mei=Madoka kn-aut-name=井上円加 kn-aut-sei=井上 kn-aut-mei=円加 aut-affil-num=2 ORCID= en-aut-name=OzawaMasatugu en-aut-sei=Ozawa en-aut-mei=Masatugu kn-aut-name=小澤正嗣 kn-aut-sei=小澤 kn-aut-mei=正嗣 aut-affil-num=3 ORCID= en-aut-name=KanazawaTomoko en-aut-sei=Kanazawa en-aut-mei=Tomoko kn-aut-name=金澤智子 kn-aut-sei=金澤 kn-aut-mei=智子 aut-affil-num=4 ORCID= en-aut-name=SaitouTaiichi en-aut-sei=Saitou en-aut-mei=Taiichi kn-aut-name=斎藤太一 kn-aut-sei=斎藤 kn-aut-mei=太一 aut-affil-num=5 ORCID= en-aut-name=NakaharaRyuichi en-aut-sei=Nakahara en-aut-mei=Ryuichi kn-aut-name=中原龍一 kn-aut-sei=中原 kn-aut-mei=龍一 aut-affil-num=6 ORCID= en-aut-name=NodaTomoyuki en-aut-sei=Noda en-aut-mei=Tomoyuki kn-aut-name=野田知之 kn-aut-sei=野田 kn-aut-mei=知之 aut-affil-num=7 ORCID= en-aut-name=NishidaKeiichiro en-aut-sei=Nishida en-aut-mei=Keiichiro kn-aut-name=西田圭一郎 kn-aut-sei=西田 kn-aut-mei=圭一郎 aut-affil-num=8 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name=尾﨑敏文 kn-aut-sei=尾﨑 kn-aut-mei=敏文 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　整形外科 affil-num=2 en-affil= kn-affil=岡山大学病院　整形外科 affil-num=3 en-affil= kn-affil=岡山大学病院　整形外科 affil-num=4 en-affil= kn-affil=岡山大学病院　整形外科 affil-num=5 en-affil= kn-affil=岡山大学病院　整形外科 affil-num=6 en-affil= kn-affil=岡山大学病院　整形外科 affil-num=7 en-affil= kn-affil=岡山大学病院　整形外科 affil-num=8 en-affil= kn-affil=岡山大学病院　整形外科 affil-num=9 en-affil= kn-affil=岡山大学病院　整形外科 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=2 article-no= start-page=129 end-page=132 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Laparoscopic surgery for mesenteric Castleman's disease kn-title=腹腔鏡下に摘出しえた上行結腸間膜発生のCastleman病の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report herein a case of mesenteric Castleman's disease which was confirmed on pathology. A 60-year-old man was admitted to our hospital complaining of abdominal pain. On the physical examination, there was no palpable mass. Computed tomography findings and magnetic resonance imaging revealed a well circumscribed, lobulated round mass on the right side of the superior mesenteric vein. Laparoscopic surgery for the mesenteric tumor was carried out to obtain a definite diagnosis and treatment. In the operative field, the mass was located on the ascending colic mesentery and measured about 3 cm in size. It was solid and surrounded by a thin fibrous capsule. The histological diagnosis of the mesenteric tumor was hyaline vascular type Castleman's disease. The postoperative course of the patient was uneventful, and he was discharged on the 10th postoperative day. en-copyright= kn-copyright= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=1 ORCID= en-aut-name=OtsukaShinya en-aut-sei=Otsuka en-aut-mei=Shinya kn-aut-name=大塚真哉 kn-aut-sei=大塚 kn-aut-mei=真哉 aut-affil-num=2 ORCID= en-aut-name=TomodaJun en-aut-sei=Tomoda en-aut-mei=Jun kn-aut-name=友田純 kn-aut-sei=友田 kn-aut-mei=純 aut-affil-num=3 ORCID= en-aut-name=FujiwaraKeishi en-aut-sei=Fujiwara en-aut-mei=Keishi kn-aut-name=藤原敬士 kn-aut-sei=藤原 kn-aut-mei=敬士 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　内科 affil-num=4 en-affil= kn-affil=光生病院　内科 en-keyword=結腸間膜 (mesocolon) kn-keyword=結腸間膜 (mesocolon) en-keyword=Castleman病 (Castleman's disease) kn-keyword=Castleman病 (Castleman's disease) en-keyword=腹腔鏡手術 (laparoscopic surgery) kn-keyword=腹腔鏡手術 (laparoscopic surgery) END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=7 article-no= start-page=1557 end-page=1596 dt-received= dt-revised= dt-accepted= dt-pub-year=1929 dt-pub=19290731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Eigene Erfahrungen der peroralen Cholecystographie mit “Kerasol.” kn-title=「ケラゾール」ヲ以テスル經口的膽嚢造影法ニ關スル經驗 en-subtitle= kn-subtitle= en-abstract= kn-abstract=余ハ各種ノ膽嚢造影法中最モ安全且簡易ナル内服法ニ對シ,他法ニ劣ラザル確實性ヲ期シ,而モ邦人ノ習慣ニ適應シタル内服造影法ヲ研究シ次ノ結論ニ達セリ. 1. 現今最モ優秀ナル膽嚢造影剤ハTetraiodophenolphthalein及ビPhenoltertraiodophthaleinナリ.余ハ前者ノ製剤Kerasolヲ使用セリ. 2. 余ノ考案ニ係ル「Kerasolヲ以テスル經口的膽嚢造影法」ハ第10節ニ記載セル處ノ如シ.準備トシテKerasol内服前1-2時間ニ於テ卵黄(3箇)ヲ食スルコトハ邦人ノ如ク脂肪ニ乏シキ食物ヲ攝ル習性ニアルモノニハ,膽嚢ヲ豫メ空虚ナラシムル為必要缺クベカラザル處置ナリ. 3. Kerasol内服ノ副作用ハ極輕微ノ嘔吐,惡心,下痢,頭痛,腹痛アレドモ一般状態ハ全然侵サルルコトナシ.内服後嘔吐ニ依リKapsel 1-2箇ヲ吐出スルコトアルモ造影ニ何等妨ゲナキヲ觀察セリ. 4. Kerasol内服ニ依ル膽嚢造影ハ概シテ10時間後ニ現ハレ, 24時間後迄持績シ, 14-18時間後最モ濃厚ナリ. 5. 膽嚢影像濃度ヲ鮮明,微弱,陰性ノ3種ニ區分スルニ健態ニ在リテハ常ニ鮮明,無石膽嚢炎ハ大部分鮮明,一小部微弱,黄疸ヲ伴フ如キ重キ膽石症ニ在リテハ微弱或ハ陰性ナリ.即チ膽道系ノ病變高度ナル程陰性ノ結果ヲ示ス. 6. 膽嚢造影法ニ於ケル各種所見ノ診断的意義ハ第14節ニ記セル處ノ如シ.就中膽嚢ノ形状ニ關シ諸家等シク甚ダ複雜ニ分類セルモ余ハ遊離型及ビ固定型ノ2類ニ區分セリ.前者ハ膽嚢底及ビ體が肝下縁ヨリ離レ糸瓜状乃至梨子状ニ下垂セルモノヲ云フ.後者ハ膽嚢が肝下縁ニ沿ヒテ存在シ僅ニ底ノ一部が懸滴状ニ下垂セルヲ云フ.健態ニ在リテハ兩型ノ比ハ遊離型:固定型::2:1ナルガ如シ.之ニ反シテ膽石症ノ際ハ遊離型:固定型::1:6ナリ.惟フニ先天性遊離型ト雖モ膽嚢周圍炎性癒着ニ依リ後天性固定型ニ變ゼルモノナルベシ.故ニ膽石症ノ際固定型膽嚢アラバ膽嚢癒着ヲ診定シテ可ナリ. 7. 膽嚢影像陽性時ノ十二指腸膽汁ノ沃度含量ハ次ノ如シ. A 膽汁 8.7-16.4 平均 12.5 mg% B 膽汁 117.0-183.0 平均 156.8 mg% C 膽汁 20.0-30.5 平均 24.1mg%膽石症患者ニ於テ膽嚢影像微弱或ハ陰性時ノ十二指腸膽汁ノ沃度含量ハ次ノ如クA膽汁ニハ著變ナキモ, B膽汁ニハ劇減シC膽汁ハ稍々減ジ, 3膽汁ノ値ニ大差ナシ.即チ嚢ノ病變著シキノミナラズ肝臓モ亦多少傷害セラルニ由来ス. A 膽汁 6.9-9.0 平均 7.9 mg% B 膽汁 0-18.8 平均 9.9 mg% C 膽汁 0-15.9 平均 8.6 mg% 8 膽嚢排泄機能検査ニハ卵黄試食ヲ以テ最良トス.卵黄食(3箇)後12分以内ニシテ膽嚢ハ収縮ヲ開始シ,概ネ2時間以内ニ排泄ヲ完了ス.膽石症ノ際ニハ膽能排泄機能ハ遲延シ或ハ不全ニ終ル. 9. 膽嚢造影法ニ依ル診斷ハ後来ノ間接診斷ヨリモー層具體的ニ明瞭ナル所見ヲ提供ス. en-copyright= kn-copyright= en-aut-name=SigenoiSiko en-aut-sei=Sigenoi en-aut-mei=Siko kn-aut-name=滋野井至孝 kn-aut-sei=滋野井 kn-aut-mei=至孝 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學泉外科教室 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支鏡下生検にて診断に至らなかった肺病変に対するCT透視下肺生検の役割 kn-title=Role of Computed Tomography Fluoroscopy-Guided Cutting Needle Biopsy of Lung Lesions After Transbronchial Examination Resulting in Negative Diagnosis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name=松井裕輔 kn-aut-sei=松井 kn-aut-mei=裕輔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=口腔関連審美に関する多軸診断アンケートの開発とそれを用いた歯学部生の実態調査 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SakudaAtsuyo en-aut-sei=Sakuda en-aut-mei=Atsuyo kn-aut-name=作田篤代 kn-aut-sei=作田 kn-aut-mei=篤代 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=造影超音波検査で描出される膵管内乳頭粘液性腫瘍の壁在結節の血管像は悪性度診断の一助になる kn-title=Vascular patterns in nodules of intraductal papillary mucinous neoplasms depicted under contrast-enhanced ultrasonography are helpful for evaluating malignant potential en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KuriharaNaoko en-aut-sei=Kurihara en-aut-mei=Naoko kn-aut-name=栗原直子 kn-aut-sei=栗原 kn-aut-mei=直子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue= article-no= start-page=36 end-page=40 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=201105 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagnosis of Oriental medicine in Dog and Cat kn-title=犬および猫の東洋医学的診断 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It is not easy to say that it is scientific clearly though in the Oriental medicine, there is a technique peculiar from the diagnosis to treatment. It is a development phase, and it is applied similar to the application to man though the Oriental medicine is being applied by the animal. This time, it explained the feature of an Oriental medicine disease in the dog and the cat. The method is the same as the method to do by the artery of the wrist that man has though Pulls with the groin artery is done in the dog and the cat. Moreover, the respiratory organ can be diagnosed,and because an inter-esting reaction to control it this time was admitted, it reports. On the other hand, it has a lot of volume of information though neither Eye and Pulls diagnosis are made a science. In addition, it reports on the diagnosis of the convulsion in the Oriental medicine this time. Moreover, this report is convinced of it that it is relate about the nervous system and pressure, and can do clarification scientific the Oriental medicine in the future. en-copyright= kn-copyright= en-aut-name=TakeuchiHiroshi en-aut-sei=Takeuchi en-aut-mei=Hiroshi kn-aut-name=竹内裕司 kn-aut-sei=竹内 kn-aut-mei=裕司 aut-affil-num=1 ORCID= en-aut-name=ImaiSakura en-aut-sei=Imai en-aut-mei=Sakura kn-aut-name=今井さくら kn-aut-sei=今井 kn-aut-mei=さくら aut-affil-num=2 ORCID= en-aut-name=KanayamaTomoyo en-aut-sei=Kanayama en-aut-mei=Tomoyo kn-aut-name=金山知世 kn-aut-sei=金山 kn-aut-mei=知世 aut-affil-num=3 ORCID= en-aut-name=KurabayashiYuzuru en-aut-sei=Kurabayashi en-aut-mei=Yuzuru kn-aut-name=倉林譲 kn-aut-sei=倉林 kn-aut-mei=譲 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=竹内犬猫病院 affil-num=2 en-affil= kn-affil=森ノ宮医療大学保健医療学部鍼灸学科 affil-num=3 en-affil= kn-affil=森ノ宮医療大学保健医療学部鍼灸学科 affil-num=4 en-affil= kn-affil=森ノ宮医療大学保健医療学部鍼灸学科 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=1 article-no= start-page=49 end-page=52 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The care of rare respiratory diseases in Japan kn-title=希少呼吸器疾患の治療・管理 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TanimotoYasushi en-aut-sei=Tanimoto en-aut-mei=Yasushi kn-aut-name=谷本安 kn-aut-sei=谷本 kn-aut-mei=安 aut-affil-num=1 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name=谷本光音 kn-aut-sei=谷本 kn-aut-mei=光音 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　呼吸器・アレルギー内科 affil-num=2 en-affil= kn-affil=岡山大学病院　呼吸器・アレルギー内科 en-keyword=希少疾病用医薬品 kn-keyword=希少疾病用医薬品 en-keyword=特発性間質性肺炎 kn-keyword=特発性間質性肺炎 en-keyword=特発性肺線維症 kn-keyword=特発性肺線維症 en-keyword=ピルフェニドン kn-keyword=ピルフェニドン END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20101231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=上部尿路上皮癌の診断における、画像所見と尿細胞診を用いた腎盂尿管鏡検査の適応に関する検討 kn-title=Indications for ureteropyeloscopy based on radiographic findings and urine cytology in detection of upper urinary tract carcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakaoAkira en-aut-sei=Takao en-aut-mei=Akira kn-aut-name=高尾彰 kn-aut-sei=高尾 kn-aut-mei=彰 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=4 article-no= start-page=655 end-page=665 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=血清對熱非凝固物質定量による癌診斷法並にその本態的研究 第1編 血清対熱非凝固物質定量による癌診断法 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=奥島団四郎 kn-aut-sei=奥島 kn-aut-mei=団四郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=11 article-no= start-page=2279 end-page=2281 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19541130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=臨床上診断が困難であつた嚢腫性胆管癌の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=青木徹 kn-aut-sei=青木 kn-aut-mei=徹 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三井春也 kn-aut-sei=三井 kn-aut-mei=春也 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部病理学教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=2 article-no= start-page=251 end-page=265 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Polysaccharide of Cancer Part 1 : Study on Diagnosis of Cancer with Precipitation Reaction applying Polysaccharide-like Substances isolated from Cancerous Tissue as the Antigen kn-title=癌の多糖類に関する研究 第1編 癌組織多糖類様物質を抗原とせる沈降反応による癌診断法に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Getting a hint from immunologic specificity of bacterial polysaccharide, the author, with Julianelle's method modified by Hosoya, isolated the polysaccharide-like substance from cellabundant and actively proliferous cancerous tissue, and applying it as antigen to patient serum in the precipitation reaction, got the following good results in diagnosis of cancer and other malignant tumors. 1) Obtained diagnosis rates are as follows: the positive results in case of patients with cancer, sarcoma and other malignant tumors ……88%; the negative results in case of patients of benign lesions ……85.1%; the average hitting rate in total cases ……86.5%. However, the differential diagnosis between cancer and sarcoma is impossible. 2) Cancerous tissue applied as antigen, when it is abundant in cells and increasing actively, shows better precipitation reaction (71.7-97.1%). Precipitation reaction by the antigen isolated from a ripe pracenta shows the result of 71.8%. While, the antigen isolated from non-cancerous tissue shows no reaction. 3) Substance of antigen consists mostly of polysaccharide, very small quantity of protein or protein-like substance being mixed in. 4) The antigen isolated from cancerous tissue by an improved method of resolution with bile, shows a successful result. 5) The application of serum-diluting method makes better result, but this does not agree with the results of complement fixation reaction and skin test. Though the true character of this precipitation reaction is unknown at present, it seems to be something like an immunologic specific reaction. 6) Above mentioned reaction is found to be pretty much available in early diagnosis, while it is of no avail in prognostic judgment. en-copyright= kn-copyright= en-aut-name=KomiyamaHiroshi en-aut-sei=Komiyama en-aut-mei=Hiroshi kn-aut-name=小見山宏 kn-aut-sei=小見山 kn-aut-mei=宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=DISI マルチホール噴射弁から噴出される噴霧微粒化のレーザ診断 kn-title=Laser Diagnostics of Spray Atomization Issued from DISI Multi-Hole Injector en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FatmaBadry Mohamed Ahmed en-aut-sei=Fatma en-aut-mei=Badry Mohamed Ahmed kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=12-2 article-no= start-page=8461 end-page=8469 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Clinical, Biochemical and Histochemical Interpretation on T. P. T. Staining as a Supplementary Diagnostic Method for Carcinoma of the Uterus Part 2 Biochemical and Histochemical Studies on T. P. T. Staining kn-title=子宮癌補助診断法としてのT. P. T. 反応の臨床的，生化学的並びに組織化学的研究 第2編 T. P. T. 反応の生化学的並びに組織化学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=T. P. T. staining is a supplementary diagnostic procedure for the detection of carcinoma of the uterus, based upon its varying stainability of endogenous dehydrogenase activity in the cells. In order to clarify an underlying mechanism of the histochemical reaction, the biochemical and histochemical studies were done, using Neo-tetrazolium chloride as an indicator of the enzyme activity, on both the cervical tissues and vaginal smears of cancer and non-cancer patients. In respect to succinic dehydrogenase activity, it appeared to be augmented 2.8 times in the carcinomatous cells than in the non-carcinomatous cells, and 2.4 times in the cancerous smears than in the non-cancerous smears. Also, in regard to endogenous dehydrogenase activity, it seemed to be increased 17 times in malignant cervical tissues than in the non-malignant tissues. Although a striking decrease in the activity was observed in the vaginal smers due possibly to its unstable reaction, it showed to be 1.6 times higher in the cancerous smears than in the non-cancerous smears. Furthermore, the exfoliative cells in the cancer patients, such as cancer cells, non-cancer cells, leucocytes and microorganisms showed a higher activity compared with those in the non-cancer patients. From the evidence above described, it is assumed that the T. P. T. positive reaction observed in the cancer patients might be due to the elevated activity in the various cells and the microorganisms and the concurrent elevation of the vaginal pH approximately close to the optimal pH for the stainability of succinic dehydrogenase. Thus, in the carcinomatous cells, T. P. T. is highly deoxidized with a resultant formation of formazan which makes its appearance in the necrobiotic cells or lipid-phagocytic cells. en-copyright= kn-copyright= en-aut-name=TorigoeMasayuki en-aut-sei=Torigoe en-aut-mei=Masayuki kn-aut-name=鳥越正之 kn-aut-sei=鳥越 kn-aut-mei=正之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産科婦人科学教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=6-1 article-no= start-page=3095 end-page=3106 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Heat-Resistant Non-Goagulating Substances of Serum Part 2. The estimation of heat-resistant non-coagulating substances in serum by means of polarography as applied to the cancer diagnosis kn-title=血清耐熱非凝固物質について 第2編 ポーラログラフによる血清耐熱非凝固物質測定の癌診断への応用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=While paying a due attention to the change in heat-coagulability of the serum of cancer patient, the author estimated the fluctuations of heat-resistant non-coagulating substance in the serum with polarography, and applying it on cancer diagnosis, studied the relationship between anemia, the leucocyte count, the rate of erythrocyte sedimentation, and the liver function In addition, with the cases with gastric cancer the author studied the relationship between the fluctuations above mentioned and various supposed to exert in fluences on the height of the polarographic wave; and obtained the following results: 1. In the patients with gastritis, gastric and duodenal ulcers the polarography gives the negative cancer reaction in 100 per cent. 2. Gastric cancer patients show the positive cancer reaction in the polarograph in 92.9 per cent. 3. In the patients with malignant tumors other than gastric tumor the cancer reaction is positive in 79.2 per cent. Negative cases are found frequently in the cases with malignant tumors such as those of mammary glands and thyroid glands not belonging to the digestive system. 4. In various diseases other than malignant tumors (excepting gastric cancer) 73 per cent of them show negative cancer reaction, but positive raction can be frequently encountered in tuberculous disease, occlusion ileus, extensive disorders in the digestive system, and diseases of the reticulo-endothelial system. 5. No direct relationship can be recognized between the heat-resistant non-coagulation reaction of serum (Tsuda-Okujima's method) and the polarographic cancer reaction. 6. Neither any direct relationship can be observed between this cancer reaction and anemia, the leucocyte count, the plasma protein content, the rate of erythrocyte sedimentation, the liver functon, and jaundice. 7. As for the cases with gastric cancer: a. No relationship can be recognized between existence or non-existence of free hydrochloric acid in gastric juice and the height of polarographic wave. b. The greater the size of gastric cancer the higher is the height of the polarographic wave. c. There is no relationship between the site of gastric cancer and the height of polarographic wave. d. In the macroscopic classification (Borrmann) of tumors, it has been found that the height of polarographic weve increases along wirh the progress of the disease from type I to type IV. e. In those histologically suggesting undifferentiation and a higher degree of malignancy, the height of the polarographii wave is higher. f. Summarily viewing the course of progress in the symptoms of gastric cancer, as the disease progresses from the early stage to the terminal stage, the height of polarographic wave becomes higher. en-copyright= kn-copyright= en-aut-name=OhmoriHitoshi en-aut-sei=Ohmori en-aut-mei=Hitoshi kn-aut-name=大森均 kn-aut-sei=大森 kn-aut-mei=均 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科教室 END start-ver=1.4 cd-journal=joma no-vol=101 cd-vols= no-issue=1-2 article-no= start-page=189 end-page=199 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Rapid diagnosis of early Mycoplasma pneumoniae infection by indirect immunofluorescence with monoclonal antibody kn-title=モノクロナール抗体を用いたMycoplasma pneumoniaeの迅速検出法 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although serological methods or culture methods of Mycoplasma pneumoniae (Mp) from throat washings are used for diagnosis of Mp infection, the patient is often discharged from the hospital before definitive results can be obtained. Therefore we have developed a rapid detection from patients' throat smears by immunofluorescence with anti-rabbit IgG. Antibody specificity to Mp and the difference of titers between each lot have been a problem, because of polyclonal antibody which is prepared by immunizing a rabbit. Two hybridoma cell lines producing monoclonal antibodies to Mp were obtained by fusion of spleen cells from BALB/c mice immunized by Mp antigen with myeloma cells (X63-Ag8-6. 5. 3.). The high specificity to Mp of these monoclonal antibodies produced by the hybridomas was affirmed ELISA, immunofluorescence, and Western blot. A few cross-reactions were recognized by ELISA between Mp antigen and other Mycoplasma antigens. No cross-reactivity was found by indirect immunofluorescence. Throat smears from 4 patients suffered from Mp infection were examined by immunofluorescence with monoclonal antibody. Specific immunofluorescence was seen in all smears. Both granular and diffuse types of fluorescence were seen in smears from case 1 and 2. Only diffuse type was found in smears from case 3 and 4. Monoclonal antibodies can be obtained at any time and amount. The method may be useful and convenient for the rapid diagnosis of Mycoplasmal pneumonia. en-copyright= kn-copyright= en-aut-name=TerasakaKaoru en-aut-sei=Terasaka en-aut-mei=Kaoru kn-aut-name=寺坂薫 kn-aut-sei=寺坂 kn-aut-mei=薫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部細菌学教室 en-keyword=Mycoplasma pneumoniae kn-keyword=Mycoplasma pneumoniae en-keyword=迅速診断法 kn-keyword=迅速診断法 en-keyword=モノクロナール抗体 kn-keyword=モノクロナール抗体 en-keyword=間接蛍光抗体法 kn-keyword=間接蛍光抗体法 END start-ver=1.4 cd-journal=joma no-vol=101 cd-vols= no-issue=1-2 article-no= start-page=53 end-page=59 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Emphysematous cholecystitis - early detection by ultrasonography - kn-title=気腫性胆嚢炎の1例―超音波診断の重要性― en-subtitle= kn-subtitle= en-abstract= kn-abstract=The ultrasonographic findings in a case of emphysematous cholecystitis were reported. Thick curvilinear high echoes with reverberation and acoustic shadows due to the air were found along the anterior surface of the gall bladder. However, no gas shadow was noted in the right upper abdomen on the plain radiograph. On the following day, an air fluid level in the lumen and a linear gas shadow in the wall of the gall bladder were demonstrated by the plain film and CT. With ultrasonography, it is possible to find small amounts of the air in the gall bladder at an early stage of emphysematous cholecystitis. en-copyright= kn-copyright= en-aut-name=KojimaKanji en-aut-sei=Kojima en-aut-mei=Kanji kn-aut-name=児島完治 kn-aut-sei=児島 kn-aut-mei=完治 aut-affil-num=1 ORCID= en-aut-name=TsuuchiYasuhiko en-aut-sei=Tsuuchi en-aut-mei=Yasuhiko kn-aut-name=津内保彦 kn-aut-sei=津内 kn-aut-mei=保彦 aut-affil-num=2 ORCID= en-aut-name=MatsunoShinsuke en-aut-sei=Matsuno en-aut-mei=Shinsuke kn-aut-name=松野慎介 kn-aut-sei=松野 kn-aut-mei=慎介 aut-affil-num=3 ORCID= en-aut-name=TakashimaHitoshi en-aut-sei=Takashima en-aut-mei=Hitoshi kn-aut-name=高島均 kn-aut-sei=高島 kn-aut-mei=均 aut-affil-num=4 ORCID= en-aut-name=OhkawaMotoomi en-aut-sei=Ohkawa en-aut-mei=Motoomi kn-aut-name=大川元臣 kn-aut-sei=大川 kn-aut-mei=元臣 aut-affil-num=5 ORCID= en-aut-name=TamaiToyosato en-aut-sei=Tamai en-aut-mei=Toyosato kn-aut-name=玉井豊理 kn-aut-sei=玉井 kn-aut-mei=豊理 aut-affil-num=6 ORCID= en-aut-name=TanabeMasatada en-aut-sei=Tanabe en-aut-mei=Masatada kn-aut-name=田邉正忠 kn-aut-sei=田邉 kn-aut-mei=正忠 aut-affil-num=7 ORCID= en-aut-name=OkaMichiko en-aut-sei=Oka en-aut-mei=Michiko kn-aut-name=岡美智子 kn-aut-sei=岡 kn-aut-mei=美智子 aut-affil-num=8 ORCID= en-aut-name=AndohAkio en-aut-sei=Andoh en-aut-mei=Akio kn-aut-name=安藤陽夫 kn-aut-sei=安藤 kn-aut-mei=陽夫 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=香川医科大学放射線医学教室 affil-num=2 en-affil= kn-affil=香川医科大学放射線医学教室 affil-num=3 en-affil= kn-affil=香川医科大学放射線医学教室 affil-num=4 en-affil= kn-affil=香川医科大学放射線医学教室 affil-num=5 en-affil= kn-affil=香川医科大学放射線医学教室 affil-num=6 en-affil= kn-affil=香川医科大学放射線医学教室 affil-num=7 en-affil= kn-affil=香川医科大学放射線医学教室 affil-num=8 en-affil= kn-affil=大川総合病院内科 affil-num=9 en-affil= kn-affil=大川総合病院外科 en-keyword=気腫性胆嚢炎 kn-keyword=気腫性胆嚢炎 en-keyword=急性胆嚢炎 kn-keyword=急性胆嚢炎 en-keyword=超音波診断 kn-keyword=超音波診断 en-keyword=CT kn-keyword=CT END start-ver=1.4 cd-journal=joma no-vol=101 cd-vols= no-issue=1-2 article-no= start-page=43 end-page=51 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Radiological diagnosis and treatment of afferent loop obstruction kn-title=輸入脚閉塞症の画像診断と治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Four cases of afferent loop obtruction were reported. Billroth II reconstruction was performed in two patients and Roux-Y reconstruction was performed in the other two patients after gastrectomy. Three of four patients complained of jaundice. CT and ultrasonography showed a dumbell-shaped cystic mass anterior to the abdominal aorta on the transverse image, and a cystic mass between the superior mesenteric vessels and the abdominal aorta on saggital view. These patients were not surgical candidates because of their poor condition. We performed the drainage of the afferent loop via a percutaneus transhepatic biliary catheter as a palliative treatment. In one case the serum bilirubin and amylase level decreased to normal range and the patient survived for 80 days. The other two patients died on the 12th and 28th day after the procedure. One patient is currently alive 20 days after the drainage procedure with improvement of clinical symptoms, serum bilirubin and amylase levels. en-copyright= kn-copyright= en-aut-name=MatsunoShinsuke en-aut-sei=Matsuno en-aut-mei=Shinsuke kn-aut-name=松野慎介 kn-aut-sei=松野 kn-aut-mei=慎介 aut-affil-num=1 ORCID= en-aut-name=KojimaKanji en-aut-sei=Kojima en-aut-mei=Kanji kn-aut-name=児島完治 kn-aut-sei=児島 kn-aut-mei=完治 aut-affil-num=2 ORCID= en-aut-name=MoriYasutane en-aut-sei=Mori en-aut-mei=Yasutane kn-aut-name=森泰胤 kn-aut-sei=森 kn-aut-mei=泰胤 aut-affil-num=3 ORCID= en-aut-name=KageyamaJunichi en-aut-sei=Kageyama en-aut-mei=Junichi kn-aut-name=影山淳一 kn-aut-sei=影山 kn-aut-mei=淳一 aut-affil-num=4 ORCID= en-aut-name=ToyamaYoshihiro en-aut-sei=Toyama en-aut-mei=Yoshihiro kn-aut-name=外山芳弘 kn-aut-sei=外山 kn-aut-mei=芳弘 aut-affil-num=5 ORCID= en-aut-name=TsuuchiYasuhiko en-aut-sei=Tsuuchi en-aut-mei=Yasuhiko kn-aut-name=津内保彦 kn-aut-sei=津内 kn-aut-mei=保彦 aut-affil-num=6 ORCID= en-aut-name=YodenMidori en-aut-sei=Yoden en-aut-mei=Midori kn-aut-name=余田みどり kn-aut-sei=余田 kn-aut-mei=みどり aut-affil-num=7 ORCID= en-aut-name=OhkawaMotoomi en-aut-sei=Ohkawa en-aut-mei=Motoomi kn-aut-name=大川元臣 kn-aut-sei=大川 kn-aut-mei=元臣 aut-affil-num=8 ORCID= en-aut-name=TamaiToyosato en-aut-sei=Tamai en-aut-mei=Toyosato kn-aut-name=玉井豊理 kn-aut-sei=玉井 kn-aut-mei=豊理 aut-affil-num=9 ORCID= en-aut-name=TanabeMasatada en-aut-sei=Tanabe en-aut-mei=Masatada kn-aut-name=田邉正忠 kn-aut-sei=田邉 kn-aut-mei=正忠 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=香川医科大学放射線医学教室 affil-num=2 en-affil= kn-affil=香川医科大学放射線医学教室 affil-num=3 en-affil= kn-affil=香川医科大学放射線医学教室 affil-num=4 en-affil= kn-affil=香川医科大学放射線医学教室 affil-num=5 en-affil= kn-affil=香川医科大学放射線医学教室 affil-num=6 en-affil= kn-affil=香川医科大学放射線医学教室 affil-num=7 en-affil= kn-affil=香川医科大学放射線医学教室 affil-num=8 en-affil= kn-affil=香川医科大学放射線医学教室 affil-num=9 en-affil= kn-affil=香川医科大学放射線医学教室 affil-num=10 en-affil= kn-affil=香川医科大学放射線医学教室 en-keyword=超音波診断 kn-keyword=超音波診断 en-keyword=CT kn-keyword=CT en-keyword=輸入脚閉塞症 kn-keyword=輸入脚閉塞症 en-keyword=PTCD kn-keyword=PTCD END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=9-10 article-no= start-page=1147 end-page=1156 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199010 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on lung cancer-associated antigens in serum detected by mouse monoclonal antibodies Part 2. The usefulness of measuring serum antigens in the diagnosis and treatment of lung cancer kn-title=マウス単クローン抗体による血中肺癌関連抗原の検討 第2編 肺癌の診断,治療における血中肺癌関連抗原測定の有用性 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To evaluate the clinical usefulness of four lung cancer-associated antigens ( LA-3, LSI-4, LSI-a, and LSI-c ), serum antigens in 107 patients with lung cancer and 35 patients with benign pulmonary diseases were measured quantitatively using a sandwich enzyme immunoassay. Pleural effusions from 20 lung cancer and 11 benign disease patients were assayed in the same manner. Mean levels of and positivity rates for each antigen in the sera of lung cancer patients were higher than in benigh diseases. Mean levels and positivity rates in stage III and IV lung cancer were significantly higher than those in stage I or II. Thus, diagnostic accuracy in lung cancer can be improved with combination assays for LA-3, LSI-4, and LSI-a. Each serum antigen level before and after chemotherapy changed according to the therapeutic effect. Indeed, the LA-3 antigen levels monitored in 3 lung cancer patients closely reflected the clinical course. Mean levels of and positivity rates for LA-3 and LSI-4 antigens in pleural effusions from lung cancer patients were significantly higher than for benign diseases. These results indicate that these 4 antigens detected in serum or pleural effusions can be clinically useful as tumor markers in lung cancer. en-copyright= kn-copyright= en-aut-name=MarukawaMasaomi en-aut-sei=Marukawa en-aut-mei=Masaomi kn-aut-name=丸川将臣 kn-aut-sei=丸川 kn-aut-mei=将臣 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Lung cancer kn-keyword=Lung cancer en-keyword=Monoclonal antibody kn-keyword=Monoclonal antibody en-keyword=Enzyme immunoassay kn-keyword=Enzyme immunoassay en-keyword=Tumor marker kn-keyword=Tumor marker END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=2 article-no= start-page=189 end-page=194 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A clinicopathological study of distal bile duct carcinoma at Fukuyama Medical Center kn-title=当院における下部胆管癌手術症例の治療成績 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We experienced 20 patients with distal bile duct carcinoma from May, 1997 to December, 2007. The male/female ratio was 11/9 and the average age was 69.6 years. The operative procedures were as follows：pancreaticoduodenectomy (PD), 9；pyrolus preserving pancreaticoduodenectomy (PPPD), 8；subtotal stomach preserving pancreaticoduodenectomy (SSPPD), 2 and hepatico-jejunostomy without resection, 1. We performed a clinicopathological study on 16 patients with distal bile duct carcinoma, excluding 3 operation-related deaths and 1 unresectable case. The cumulative survival rate was 70% at 3 years and 11% at 5 years. The 3-year survival rates at fStageⅡ, fStageⅣa and fStageⅣb were 100%, 80% and 0%, respectively. Log-rank analysis revealed that pathological pancreatic and duodenal invasion and curative resectability may be prognostic factors, while lymph node metastasis and perineural and stump invasion did not affect prognosis. Six recurrences in the 11 curative resection cases (54.5%) were observed；therefore, postoperative systemic chemotherapy is warranted to curtail recurrence in advanced distal bile duct carcinoma. en-copyright= kn-copyright= en-aut-name=HamanoRyosuke en-aut-sei=Hamano en-aut-mei=Ryosuke kn-aut-name=濱野亮輔 kn-aut-sei=濱野 kn-aut-mei=亮輔 aut-affil-num=1 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=稲垣優 kn-aut-sei=稲垣 kn-aut-mei=優 aut-affil-num=2 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=3 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=徳永尚之 kn-aut-sei=徳永 kn-aut-mei=尚之 aut-affil-num=4 ORCID= en-aut-name=TsunemitsuYosuke en-aut-sei=Tsunemitsu en-aut-mei=Yosuke kn-aut-name=常光洋輔 kn-aut-sei=常光 kn-aut-mei=洋輔 aut-affil-num=5 ORCID= en-aut-name=OhtsukaShinya en-aut-sei=Ohtsuka en-aut-mei=Shinya kn-aut-name=大塚眞哉 kn-aut-sei=大塚 kn-aut-mei=眞哉 aut-affil-num=6 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=岩川和秀 kn-aut-sei=岩川 kn-aut-mei=和秀 aut-affil-num=7 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=8 ORCID= en-aut-name=SonobeHiroshi en-aut-sei=Sonobe en-aut-mei=Hiroshi kn-aut-name=園部宏 kn-aut-sei=園部 kn-aut-mei=宏 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=4 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=5 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=6 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=7 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=8 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=9 en-affil= kn-affil=中国中央病院　臨床検査科 en-keyword=下部胆管癌 (distal bile duct carcinoma) kn-keyword=下部胆管癌 (distal bile duct carcinoma) en-keyword=手術 (operation) kn-keyword=手術 (operation) en-keyword=予後規定因子 (independent prognostic factors) kn-keyword=予後規定因子 (independent prognostic factors) END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=胃がん検診における高濃度硫酸バリウムの診断精度評価　－がん登録との記録照合による解析－ kn-title=The diagnostic validity of high-density barium sulfate in gastric cancer screening －Follow-up of screenees by record linkage with the Osaka Cancer Registry－ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YamamotoKenyu en-aut-sei=Yamamoto en-aut-mei=Kenyu kn-aut-name=山本兼右 kn-aut-sei=山本 kn-aut-mei=兼右 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=X線画像による臨床所見に基づいた幼児股関節診断支援システム kn-title=Infant Hip Joint Diagnostic Support System Based on Clinical Manifestations in X-ray Images en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HondaMitsugi en-aut-sei=Honda en-aut-mei=Mitsugi kn-aut-name=本田貢 kn-aut-sei=本田 kn-aut-mei=貢 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=48 cd-vols= no-issue= article-no= start-page=49 end-page=54 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=19790325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Prevalence of periCardial effusion in patients with rheumatoid arthritis -An echocardiographic study- kn-title=慢性関節リウマチ患者における心包液貯留―超音波診断装置による検索― en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to determine the incidence of pericardial effusion in rheumatoid arthritis (RA), echocardiographic studies were performed on patients with classical or definite RA as determined by ARA criteria, none of whom showed any clinical cardiac symptoms at the time of examination. Of 50 RA patients studied so far, fifteen (30%) showed evidence of posterior pericardial effusion, as recorded on the strip charts. Additionally, in one full-blown case of rheumatoid vasculitis, massive accumulation of pericardial fluid was demonstrable. Compared to those without pericardial effusion, patients shown to have pericardial fluid tended to have decreased RBC, Hct, Hgb, serum protein concentration and increased ESR. The statistical difference between the two groups was significant (P<0.005). The most conspicuous difference between the two, however, was noted in the degree of hypoalbuminemia that is more profound in the effusion positive group (P<0.005). The possible cause of fluid retention in the pericardial cavity in RA was briefly discussed. en-copyright= kn-copyright= en-aut-name=IshiiHirofumi en-aut-sei=Ishii en-aut-mei=Hirofumi kn-aut-name=石井廣文 kn-aut-sei=石井 kn-aut-mei=廣文 aut-affil-num=1 ORCID= en-aut-name=DomyoMichihiro en-aut-sei=Domyo en-aut-mei=Michihiro kn-aut-name=道明道弘 kn-aut-sei=道明 kn-aut-mei=道弘 aut-affil-num=2 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=3 ORCID= en-aut-name=TakasugiKiyoshi en-aut-sei=Takasugi en-aut-mei=Kiyoshi kn-aut-name=高杉潔 kn-aut-sei=高杉 kn-aut-mei=潔 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=2 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=3 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=4 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue= article-no= start-page=39 end-page=41 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An evaluation of pancreatographic findings in the differential diagnosis of chronic pancreatitis and pancreatic cancer kn-title=慢性膵炎と膵癌の鑑別診断―分枝像による検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=In an attempt to evaluate the pancreatographic findings, particularly of the pancreatic duct branches, in the differrential diagnosis of chronic pancreatitis and Pancreatic cancer, twenty seven post mortem pancreases were subjected to retrograde pancreatography and histological examination. The materials consist of 15 cases with chronic pancreatitis and 12 cases with pancreatic cancer. The results obtained are as follows. 1) In cases with chronic pancreatitis, abnormal findindings such as irregular dilatation, straightening-hardening, narrowing-stenosis of the pancreatic duct branches were more common. 2) Incases with pancreatic cancer, abnormal findings such as diminishing, irregular dilatation, narrowing-stenosis of the pancreatic duct branches were more common. 3) Abnormal findings in cases with chronic pancreatitis reveled the dendency of diffuse expansion, on the other hand, in case with pancreatic cancer revealed the tendency of localized expansion. 4) When the fine and clear pancreatography was obtained, it was possible to predict the presence of chronic inflammation or tumor cell infiltration from above findings and tendencies. On the contrary, in cases with localized, severe chronic pancreatitis and in cases with complicated, it was difficult to differentiate the pancreatic cancer from chronic pancreatitis. en-copyright= kn-copyright= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=3 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=4 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=2 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=3 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=4 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=5 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue= article-no= start-page=45 end-page=52 dt-received= dt-revised= dt-accepted= dt-pub-year=1985 dt-pub=19850330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Endoscopic diagosis of gastric malignant lymphoma kn-title=胃悪性リンパ腫の内視鏡診断 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To delineate the pitfalls and counter-measures in the endoscopic diagnosis of gastric malignant lymphoma (GML), reviewed were 32 cases of primary GML and 16 cases of systemic ML with gastric involvement (secondary GML). 1) Accurate diagnosis of GML had been made in only 13 cases of primary GML ; 18 cases had been diagnosed of gastric cancer (GC); the remaining one of benign ulcer (BU). Review of the endoscopic films, however, revealed more than two of the three findings characteristic, but not pathognomomic, of GML in 84 percent. This result indicates that possibility of GML must be kept in mind in the differential diagnosis of malignant lesions despite its rarity, because endoscopists tend to be predisposed with an impression of GC. 2) Follow-up examinations made in nine cases of primary GML revealed marked changes in endoscopic findings in three cases : healing of an ulcer lesion in one case, healing of an ulcer lesion on an unchanged tumor in another and enlargement of a tumor in the remaining one. The first case had been followed up for two years with an impression of BU. This result indicates that improvement of ulcer does not necessarily rule out GML because it can show "malignant cycle" just as GC. 3) Endoscopic biopsy performed in 30 cases of primary GML had led to accurate diagnosis in only 16 cases and erroneous diagnosis of GC in five and no malignancy in nine. Review of the cases revealed the importance of having suspicion of GML at first from endoscopic findings, because it can lead to an increase of the number of biopsy specimens, careful selection of biopsy sites, careful use of biopsy instruments to obtain good specimens and closer contact with pathologists. 4) Prospective studies on systemic ML revealed gastric involvement in 17 percent. Examinations of the GI tract, especially of the stomach is one of the important steps for staging of systemic ML and deciding therapeutic modalities. 5) It is extremely difficult to diffierentate primary GML and secondary GML from endoscopic findings alone, although there are a few findings characteristic of the latter. en-copyright= kn-copyright= en-aut-name=MiyakeHirofumi en-aut-sei=Miyake en-aut-mei=Hirofumi kn-aut-name=三宅啓文 kn-aut-sei=三宅 kn-aut-mei=啓文 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=YasuokaMasatoshi en-aut-sei=Yasuoka en-aut-mei=Masatoshi kn-aut-name=安岡正敏 kn-aut-sei=安岡 kn-aut-mei=正敏 aut-affil-num=3 ORCID= en-aut-name=OkaHiroo en-aut-sei=Oka en-aut-mei=Hiroo kn-aut-name=岡浩郎 kn-aut-sei=岡 kn-aut-mei=浩郎 aut-affil-num=4 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=5 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=6 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=7 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=8 ORCID= en-aut-name=OhnoshiTaisuke en-aut-sei=Ohnoshi en-aut-mei=Taisuke kn-aut-name=大熨泰亮 kn-aut-sei=大熨 kn-aut-mei=泰亮 aut-affil-num=9 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=2 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=3 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=4 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=5 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=6 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=7 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=8 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=9 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=10 en-affil= kn-affil=岡山大学医学部第2内科 END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue= article-no= start-page=17 end-page=21 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=200612 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Development of DNA markers for misbranded beef and meat quality kn-title=DNA診断で偽装表示と美味しい牛肉を見抜く en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MannenHideyuki en-aut-sei=Mannen en-aut-mei=Hideyuki kn-aut-name=万年英之 kn-aut-sei=万年 kn-aut-mei=英之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=神戸大学大学院首然科学研究科 END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=1 article-no= start-page=67 end-page=71 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Japanese guideline for management of cervical spondylotis myelopathy kn-title=頚椎症性脊髄症の診療ガイドライン en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TanakaMasato en-aut-sei=Tanaka en-aut-mei=Masato kn-aut-name=田中雅人 kn-aut-sei=田中 kn-aut-mei=雅人 aut-affil-num=1 ORCID= en-aut-name=SugimotoYoshihisa en-aut-sei=Sugimoto en-aut-mei=Yoshihisa kn-aut-name=杉本佳久 kn-aut-sei=杉本 kn-aut-mei=佳久 aut-affil-num=2 ORCID= en-aut-name=MisawaHaruo en-aut-sei=Misawa en-aut-mei=Haruo kn-aut-name=三澤治夫 kn-aut-sei=三澤 kn-aut-mei=治夫 aut-affil-num=3 ORCID= en-aut-name=TakahataTomohiro en-aut-sei=Takahata en-aut-mei=Tomohiro kn-aut-name=高畑智宏 kn-aut-sei=高畑 kn-aut-mei=智宏 aut-affil-num=4 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name=尾﨑敏文 kn-aut-sei=尾﨑 kn-aut-mei=敏文 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学 END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=1 article-no= start-page=39 end-page=42 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A clinicopathological study of distal bile duct carcinoma at Fukuyama Medical Center kn-title=当院における下部胆管癌手術症例の治療成績 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We experienced 20 patients with distal bile duct carcinoma from May, 1997 to December, 2007. The male/female ratio was 11/9 and the average age was 69.6 years. The operative procedures were as follows : pancreaticoduodenectomy (PD), 9 ; pyrolus preserving pancreaticoduodenectomy (PPPD), 8 ; subtotal stomach preserving pancreaticoduodenectomy (SSPPD), 2 and hepatico-jejunostomy without resection, 1. We performed a clinicopathological study on 16 patients with distal bile duct carcinoma, excluding 3 operation-related deaths and 1 unresectable case. The cumulative survival rate was 70% at 3 years and 11% at 5 years. The 3-year survival rates at fStageII, fStageIVa and fStageIVb were 100%, 80% and 0%, respectively. Log-rank analysis revealed that pathological pancreatic and duodenal invasion and curative resectability may be prognostic factors, while lymph node metastasis and perineural and stump invasion did not affect prognosis. Six recurrences in the 11 curative resection cases (54.5%) were observed ; therefore, postoperative systemic chemotherapy is warranted to curtail recurrence in advanced distal bile duct carcinoma. en-copyright= kn-copyright= en-aut-name=HamanoRyosuke en-aut-sei=Hamano en-aut-mei=Ryosuke kn-aut-name=濱野亮輔 kn-aut-sei=濱野 kn-aut-mei=亮輔 aut-affil-num=1 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=稲垣優 kn-aut-sei=稲垣 kn-aut-mei=優 aut-affil-num=2 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=3 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=徳永尚之 kn-aut-sei=徳永 kn-aut-mei=尚之 aut-affil-num=4 ORCID= en-aut-name=TsunemitsuYosuke en-aut-sei=Tsunemitsu en-aut-mei=Yosuke kn-aut-name=常光洋輔 kn-aut-sei=常光 kn-aut-mei=洋輔 aut-affil-num=5 ORCID= en-aut-name=OhtsukaShinya en-aut-sei=Ohtsuka en-aut-mei=Shinya kn-aut-name=大塚眞哉 kn-aut-sei=大塚 kn-aut-mei=眞哉 aut-affil-num=6 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=岩川和秀 kn-aut-sei=岩川 kn-aut-mei=和秀 aut-affil-num=7 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=8 ORCID= en-aut-name=SonobeHiroshi en-aut-sei=Sonobe en-aut-mei=Hiroshi kn-aut-name=園部宏 kn-aut-sei=園部 kn-aut-mei=宏 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=4 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=5 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=6 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=7 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=8 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=9 en-affil= kn-affil=中国中央病院　臨床検査科 en-keyword=下部胆管癌 (distal bile duct carcinoma) kn-keyword=下部胆管癌 (distal bile duct carcinoma) en-keyword=手術 (operation) kn-keyword=手術 (operation) en-keyword=予後規定因子 (independent prognostic factors) kn-keyword=予後規定因子 (independent prognostic factors) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=94 end-page=99 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case report of linitis plastica type of colon cancer. kn-title=腟擦過細胞診で確認されたびまん浸潤型大腸癌 en-subtitle= kn-subtitle= en-abstract=A 43-year-old women, complaining of abdominal pain and menstrual irregularity was found suffering from adenocarcinoma of the transverse colon by cytology tests for vaginal smear and ascites. She was operated for colonic obstruction palliatively because of the extensive lesions and died 2 months after surgery for all that of the intensive cancer therapy. The histological diagnosis was primary linitis plastica type of carcinoma of the transverse colon. Carcer involvement to the ovaries and uterine tubes could possibly be responsible for the positive cytology test for vaginal smear. This rare type of careinoma demonstrates certain clinicopathological characteristics that differ from those of the ordinary colonic carcinomas, such as unfavourable prognosis with the difficulty for diagnosis due to minimal mucosal changes and the marked thickend wall of the tumor being unable to perform endoscopic studies. kn-abstract=原発性びまん浸潤型大腸癌は，全大腸癌症例の1％未満と比較的稀な疾患であり，一般大腸癌症例とくらべてその予後の悪いことで知られている。その原因の一つとして，確定診断の困難さがあるが，これは粘膜病変の欠如のために生検で確論がつきにくい点にある。我々の症例は，43歳の女性で，横行結腸に原発した症例である。腹痛を訴えて入院後，急速にイレウス状態となり，注腸検査で横行結腸の高度な狭窄を認めた。大腸ファイバースコープは腹痛のため病変部まで届かず，膣擦過細胞診およびダグラス窩穿刺腹水細胞診にて腺癌細胞を確認できた。手術所見はP（3）H（0）S（3）N（4）で，姑息切除に終わった。本症は手術時の進行度がきわめて高度であるので，本症を疑って確診のつかない症例には，上記のような細胞診も試みてみるべきと思われる。 en-copyright= kn-copyright= en-aut-name=HiraiShunichi en-aut-sei=Hirai en-aut-mei=Shunichi kn-aut-name=平井俊一 kn-aut-sei=平井 kn-aut-mei=俊一 aut-affil-num=1 ORCID= en-aut-name=SuzukaIchio en-aut-sei=Suzuka en-aut-mei=Ichio kn-aut-name=鈴鹿伊智雄 kn-aut-sei=鈴鹿 kn-aut-mei=伊智雄 aut-affil-num=2 ORCID= en-aut-name=MorisueShinhachi en-aut-sei=Morisue en-aut-mei=Shinhachi kn-aut-name=森末慎八 kn-aut-sei=森末 kn-aut-mei=慎八 aut-affil-num=3 ORCID= en-aut-name=SodaMitsuhiro en-aut-sei=Soda en-aut-mei=Mitsuhiro kn-aut-name=曽田益弘 kn-aut-sei=曽田 kn-aut-mei=益弘 aut-affil-num=4 ORCID= en-aut-name=TokunoTeruo en-aut-sei=Tokuno en-aut-mei=Teruo kn-aut-name=得能輝男 kn-aut-sei=得能 kn-aut-mei=輝男 aut-affil-num=5 ORCID= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=6 ORCID= en-aut-name=SunakawaMitsuru en-aut-sei=Sunakawa en-aut-mei=Mitsuru kn-aut-name=砂川満 kn-aut-sei=砂川 kn-aut-mei=満 aut-affil-num=7 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大塚昭雄 kn-aut-sei=大塚 kn-aut-mei=昭雄 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=8 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=9 en-affil= kn-affil=平田市立病院外科 en-keyword=びまん浸潤型大腸癌 kn-keyword=びまん浸潤型大腸癌 en-keyword=スキルス大腸癌 (Scirrhous Carcinoma of the Colon) kn-keyword=スキルス大腸癌 (Scirrhous Carcinoma of the Colon) en-keyword=Ⅳ型大腸癌 kn-keyword=Ⅳ型大腸癌 en-keyword=Linitis Plastica型大腸癌 (Linitis Plastica Type of Carcinoma) kn-keyword=Linitis Plastica型大腸癌 (Linitis Plastica Type of Carcinoma) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=39 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical evaluation of co-examination by sigmoidoscopy and barium enema study for early diagnosis of colon cancer kn-title=大腸癌早期診断による注腸・内視鏡同日併用法 ―診断能および検査前日食の検討― en-subtitle= kn-subtitle= en-abstract=The present study was performed (1) to evaluate the validity of co-examination by sigmoidoscopy and barium enema study for the early diagnosis of colon cancer and (2) to find the most suitable preparation method for the co-examination. The co-examination was performed on 94 patients : those with abdominal symptoms and signs suggestive of colonic diseases : those with positive occult blood test in stool : or those asking for the routine examination of the colon. The examination revealed 5 cases of colon cancer (2 with early cancer and 3 with advanced cancer) and 26 eases (32 lesions) with colon polyp. The high detection rate of colonic neoplasms, especially of minute lesions, along with the high rate of early lesions among cancers suggested the validity of the co-examination method for the early diagnosis of colon cancer. The method was not time-consuming and not demanding for both patients and doctors, but was effective in detecting minute lesions by allowing a doublecheck in the high-risk recto-sigmpid region ; in addition, the upper colon could be examined by X-ray. The comparative studies on the currently popular Preparation method (modified Brown's method) and a new method with retort foods (Sankenclean, Sanwa Kagaku Kenkyusho Co., Ltd) revealed that the latter was significantly more effective in cleaning colon lumen and visualizing fine network pattern of the colonic mucosa. In addition, the patients were more satisfied with the taste of the latter. kn-abstract=注腸・内視鏡同日併用法の大腸早期癌診断における有用性の検討，その診断能向上のための検査前日食改善を目的に，同法を施行した94例の診断能，従来のBrown変法に準じた献立食とレトルト食（サンケンクリン）とのX線画像の質，内視鏡時の残渣の程度，被検者への味のアンケートを分析した。発見大腸腫瘍は癌5例（早期癌2例，進行癌3例），ポリープ26例32病変である。早期癌はともにポリープの形態をとり，注腸，内視鏡とも病変を指摘できた。病変の好発部位である直腸・S状結腸で注腸・内視鏡によるダブルチェックができる。前日食の検討ではレトルト食が従来の献立食と比し，注腸・内視鏡ともに優れた腸内洗浄能を有し，味のアンケートからも劣ることはなかった。大腸癌早期発見の2次スクリーニングとして，レトルト食を前日食とする同法の有用性が示された。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=IshibashiTadaaki en-aut-sei=Ishibashi en-aut-mei=Tadaaki kn-aut-name=石橋忠明 kn-aut-sei=石橋 kn-aut-mei=忠明 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=7 ORCID= en-aut-name=NakaiMutsurou en-aut-sei=Nakai en-aut-mei=Mutsurou kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=8 ORCID= en-aut-name=HayashimotoKanae en-aut-sei=Hayashimoto en-aut-mei=Kanae kn-aut-name=林本加奈枝 kn-aut-sei=林本 kn-aut-mei=加奈枝 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=5 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=6 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=大腸早期癌 (Ealry diagnosis of colon cancer) kn-keyword=大腸早期癌 (Ealry diagnosis of colon cancer) en-keyword=注腸・内視鏡同日併用法 (Co-examination by sigmoidoscopy and barium enema study) kn-keyword=注腸・内視鏡同日併用法 (Co-examination by sigmoidoscopy and barium enema study) en-keyword=大腸検査前処置 (Preparation for colon examination) kn-keyword=大腸検査前処置 (Preparation for colon examination) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=24 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Early diagnosis of pancreatic cancertrial of a mass screening test for detecting early pancreatic cancer kn-title=膵癌の早期診断法の検討 ―膵集検の試み― en-subtitle= kn-subtitle= en-abstract=There is no other way of curing pancreatic cancer than early diagnosis and resection. However, an effective protocol has not been established for detecting early pancreatic cancer among asymptomatic populations by means　of a mass screening test. Therefore, a prospective study was attempted on 776 patients who came to Medical Clinic of Misasa Branch Hospital, Okayama University Medical School mostly for a routine annual check-up. The following tentative protocol was proposed, based on the retrospective analyses of our 13 patients with early pancreatic cancer: (1) a first step test includes serum amylase, elastase Ⅰ, alkaline phosphatase, r-GTP, carcinoembryonic antigen, fasting blood sugar and routine abdominal ultrasonography (US); (2) a second step test includes thorough abdominal US with various kinds of probes and patients' positioning which was performed on individuals with abnormal findings on the first step test, (3) a third step test includes ERCP which was performed on individuals with abnormal or questionable findings on the second step test. Further detail examinations were performed when ERCP was abnormal or questionable. Consequently 357 patients (46% of the total 776 patients) underwent thorough US and 45 patients (5.8%) underwent ERCP. ERCP findings included pancreatic cancer in two patients, suspect of pancreatic cancer in three, advanced chronic pancreatitis in two, equivocal as for chronic pancreatitis (according to the Cambridge classification) in nine, and normal in 29. Final diagnosis was early pancreatic cancer in one patient, advanced pancreatic cancer in two, and calcified chronic pancreatitis in two; detection rate of pancreatic cancer (0.39%) in this series was slightly higher than that usually reported with a mass screening test for stomach cancer. From a cost-benefit point of view, however, examinations for the pancreas cost 2.6 times as much as those for the stomach. Further studies are needed (1) to refine the protocol, (2) to improve cost-benefit efficiency, (3) and also to confirm by follow-up that no cases of pancreatic cancer have passed through the test undetected. kn-abstract=膵癌を治癒に導くためには早期診断，早期切除以外に方法はない。そこで，無症状者のなかから早期膵癌を発見するためのスクリーニング法を検討するためProspective studyを実施した。人間ドック目的の来院患者を主とする三朝分院外来患者776名を対象とし，一次スクリーニング検査として，血清アミラーゼ，エラスターゼⅠ，CA19－9，アルカリフォスファターゼ，γ-GTP，血糖値の測定および腹部超音波検査を施行し，異常者に対して二次スクリーニングとして腹部超音波検査の再精査およびERCPを施行した。その結果，早期膵癌1例および進行膵癌2例を検出し，膵癌発見率は0.39％　と満足のいく結果が得られた。しかし一次スクリーニング検査の要精検率は46％　と高値を示したこと，一次スクリーニング検査の費用は胃集検の約3.3倍，二次スクリーニング検査の費用は胃精査の約2.6倍かかることからcost-benifitの面で問題となった。また見逃し症例の有無をモニターするためfollow upも今後の問題として残った。 en-copyright= kn-copyright= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越知浩二 kn-aut-sei=越知 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=3 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=膵集検 (Mass screening) kn-keyword=膵集検 (Mass screening) en-keyword=早期膵癌 (Early pancreatic cancer) kn-keyword=早期膵癌 (Early pancreatic cancer) en-keyword=膵癌の早期診断 (Early diagnosis of pancreatic cancer) kn-keyword=膵癌の早期診断 (Early diagnosis of pancreatic cancer) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=17 end-page=23 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical evaluation of endoscopic ultrasonography (EUS) in the diagnosis of gastric disease. kn-title=胃疾患診断における超音波内視鏡の有用性の検討 en-subtitle= kn-subtitle= en-abstract=We performed EUS in seven cases with gastric cancer, one with gastric malignant lymphoma, two with submucosal tumor of the stomach (SMT), two with tumourous compression by extra-gastric organs and three with others. Except one case with early gastric cancer, the depth of cancerous lnvasion was correct1y diagnosed by EUS. It was posible to detect which layer had SMT in the 5 layer strcture of the gastric wall by EUS and it was helpful in determination of histological origin of SMT. Furthermore EUS was able to make the differential diagnosis between SMT and tumourous compression by extra gastric organ. Our result showed that EUS was a useful procedure in the diagnosis of gastric diseases. kn-abstract=ラジアルセクタ式超音波内視鏡（EUS）を，15例の胃疾患患者に用い，その有用性を検討した。胃癌の深達度診断は併存潰瘍を有するm癌の1例をsm癌とした以外は，いずれも正診であり，胃癌の深達度診断にEUSが有用であることが示唆された。その他，胃粘膜下腫瘍の占拠部位や発育様式の診断や壁外性圧排との鑑別など胃疾患の診断にEUSの有用性が示唆され，文献的考察を加えて報告した。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越知浩二 kn-aut-sei=越知 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=4 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=5 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=超音波内視鏡 (Endoscopic ultrasonography) kn-keyword=超音波内視鏡 (Endoscopic ultrasonography) en-keyword=胃癌 (Gastric cancer) kn-keyword=胃癌 (Gastric cancer) en-keyword=胃粘膜下腫瘍 (Submucosal tumor of the stomach) kn-keyword=胃粘膜下腫瘍 (Submucosal tumor of the stomach) en-keyword=癌深達度診断 (Diagnosis of the depth of cancerous invasion) kn-keyword=癌深達度診断 (Diagnosis of the depth of cancerous invasion) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=12 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Characteristic pancreatographic findings in chronic pancreatitis and their diagnostic value. …Studies on post mortem pancreas… kn-title=慢性膵炎における膵管X線像の診断学的価値 ―屍体膵を用いての検討― en-subtitle= kn-subtitle= en-abstract=Postmortem pancreas tissue was prepared within 6 hours of death for the comparative study of pancreatographic findings and histological findings to define characteristic pancreatographic findings of chronic pancreatitis and determine their diagnostic value. Pancreas tissue was obtained from 25 patients with chronic pancreatitis and 125 with a normal pancreas. Among various pancreatographic findings, irregular dilatation and irregular arrangement of the branches of the pancreatic duct, and also irregular dilatation, rigidity with irregular margin and stenosis with irregular margin of the main pancreatic duct showed the highest sensitivity. specificity, positive predictive value and negative predictive value and conseqently had the highest diagnostic valus. However, the sensitivity was not high enough, indicating that the above pancreatographic findings could be absent at the site of positive histological findings in mild chronic pancreatitis. kn-abstract=慢性膵炎25例および対照として正常例125例計150例の新鮮剖検膵を用いて膵管造影を行い，X線所見と同部位の組織所見とを厳密に対比させ，慢性膵炎における各X線所見の診断学的価値を検討した。その結果，主膵管像では不整拡張像，硬化＋辺縁不整像，狭窄＋辺縁不整像が，分枝像では不整拡張像および不整配列像が，positive predictive value（PPV），specificity（Sf），negative predictive value（NVP）ともに77.1～100％　の高率を示した。しかしsensitivity（St）は，2.1～18.1％　と低率であった。したがって，これらの所見は慢性膵炎を診断する上で組織予見性および特異性に優れた診断的価値のあるX線所見と言える。しかし一方では軽症の慢性膵炎の検出能はあまりよくないという限界が膵管造影法にはある。 en-copyright= kn-copyright= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=1 ORCID= en-aut-name=MatumotoShuuji en-aut-sei=Matumoto en-aut-mei=Shuuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=2 ORCID= en-aut-name=OchiKouji en-aut-sei=Ochi en-aut-mei=Kouji kn-aut-name=越知浩二 kn-aut-sei=越知 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=4 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) en-keyword=膵管造影像 (pancreatogpaphy) kn-keyword=膵管造影像 (pancreatogpaphy) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=61 end-page=66 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Angiography system combined with Toshiba BV-type X-TV Equipment. 2. Stereo-magnification system. kn-title=東芝BV型XTV装置を併用したANGIO graphy systemの使用経験（第2報　立体拡大撮影システム） en-subtitle= kn-subtitle= en-abstract=Angiography of the head and abdominal region gives a good deal of peculiar information for the diagnosis of nature of pathological lesions. When angiography could be performed by stereo-magnification radiography, the radiography gives better information for physicians. In this article, we tried angiography by the stereomagnifying radiography system utilizing X-TV equipment for examination of digestive system. 1. To magnify film image, the film changer was modified to move up and down, because the board of TV table did not change vertically. The board of TV table was also modified to slide more widely. The modifications could make it possible to magnify the film image by two times. 2. To use the X-TV equipment brought some advantages as follows it became very easy for us to convert the X-TV system from fluoroscopy to radiography, and contact seriography was easily changed to stereo-magnification seriography. kn-abstract=我々は，既設の消化管診断用X線TV装置（東芝BV型）を使用した立体拡大撮影システムを検討した。1．消化管診断用X線TV装置の透視天板の高さが一定であるため，従来のフィルムチェンジャー（AOT）では不可能であったが，上下動可能なフィルムチェンジャー（福放FC-10L特）を改良試作したことで最大2倍までの立体拡大撮影が可能となった。2．透視観察から撮影へ，コンタクト撮影から拡大連続撮影，立体撮影から立体拡大連続撮影へと併用して行うことが非常に簡単にできて被検者の負担軽減と多目的使用が可能となった。3．観察条件と立体感については，拡大率を変化させて，その立体感について検討した結果は、観察距離については，各拡大率における立体視しやすい距離は存在し，拡大率が2倍の場合には，観察距離を大きくするほど立体感も増加し，立体視し易い傾向が示された。 en-copyright= kn-copyright= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=1 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=2 ORCID= en-aut-name=MatsushimaKishio en-aut-sei=Matsushima en-aut-mei=Kishio kn-aut-name=松島紀志夫 kn-aut-sei=松島 kn-aut-mei=紀志夫 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院放射線部 en-keyword=立体拡大撮影 (Stereo-magnification radiography) kn-keyword=立体拡大撮影 (Stereo-magnification radiography) en-keyword=フィルム連続撮影装置 (Fiim changer) kn-keyword=フィルム連続撮影装置 (Fiim changer) en-keyword=立体感 (Stereoscopic image) kn-keyword=立体感 (Stereoscopic image) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=56 end-page=60 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Angiography system combined with Toshiba BV type X-TV equipment. 1. Whole limb serial aort-arteriography kn-title=東芝BV型XTV装置を併用したANGIO graphy systemの使用経験（第1報　下肢連続撮影装置） en-subtitle= kn-subtitle= en-abstract=A whole-limb serial aort-arteriography system constituted of BV-type X-TV and extralarge film changer was developed and used clinically. The results were as foll-ows. 1. By improving functions of the board of TV table, changes from fluoroscopy to radiography became easier in whole limb serial aort-arteriography. 2. By using LS-Ⅱ screen and 1.0cm edge filter, we could get well compensated X-ray photographs. kn-abstract=消化管診断用X線TV装置の天板機能を改良し，種々のフィルムチェンジャー，X線管球を組み合わせることにより，中規模病院において，スペース，経費などの点で有利な，血管造影システムを組むことができた。第1報では，このうち，下肢連続撮影システムについて紹介する。1．透視から造影まで，迅速に移行できるシステムとなった。2．スペース，経費の点で有利である。3．濃度補償については，LS-Ⅱ増感紙と，1.0cmエッジフィルターにより，体型によらず，全下肢にわたり，十分な補償効果が得られる。4．さらに長い長尺カセッテの開発が望まれる。 en-copyright= kn-copyright= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=1 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=2 ORCID= en-aut-name=MatsushimaKishio en-aut-sei=Matsushima en-aut-mei=Kishio kn-aut-name=松島紀志夫 kn-aut-sei=松島 kn-aut-mei=紀志夫 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院放射線部 en-keyword=全下肢連続動脈造影 (whole-limb serial aort-arteriography) kn-keyword=全下肢連続動脈造影 (whole-limb serial aort-arteriography) en-keyword=長尺フィルムチェンジャー (extra-large-film changer) kn-keyword=長尺フィルムチェンジャー (extra-large-film changer) en-keyword=X-TV台天板 (the board of TV table)　 kn-keyword=X-TV台天板 (the board of TV table)　 en-keyword=濃度補償 (compensation of density) kn-keyword=濃度補償 (compensation of density) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=29 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagnosis of chronic pancreatitis kn-title=慢性膵炎の診断 ―画像診断と機能検査の併用による― en-subtitle= kn-subtitle= en-abstract=Endoscopic retrograde cholangiopancreatography (ERCP), ultrasonography (US), computed tomography (CT), exocrine pancreatic function test (EX), endocrine pancreatic function test (EN), and analysis of pure pancreatic juice (PPJ) are currently available for the investigation of pancreatic diseases. The purpose of the present study is to evaluate the roles and preferable combinations of these tests in the diagnosis of chronic pancreatitis and then to propose a way to describe the results of the tests along with diagnosis for a better understanding of the disease process. Comparative studies of imaging, EX and EN led to the following conclusions. 1) imaging procedures (ERCP, US and CT) are mandatory, partly because they were frequently the test that showed diagnostic changes and partly because they often gave key information for operative treatment. Among the imaging procedures, ERCP combined with US and/or CT is mandatory because these combinations alone can reveal detailes of structural changes attendant on chronic pancreatitis. 2) EX is also mandatory, because it was occasionally the only test that showed diagnostic changes and partly because it often gave important information for medical treatment. 3) EN is also important, not because it was indispensable for detecting chronic pancreatitis, but because it often gave important information for medical treatment. For btter understanding of the disease process as well as diagnosis, we propose, as suggested by Seligson, that the test used for the establishment of the diagnosis and the degree as well as extent of abnormalities. An example is "Calcified chronic pancreatitis, alcoholic, diffuse, ERCP-3, US-2, CT-3, EX-2, EN-1, Lf(+)". This attitude will lead to a more rational approach to both diagnosis and treatment. kn-abstract=近年，各種膵疾患に対する検査法の発達には目を見張るものがあるが，実際の運用にあたっては各検査法の適応，限界，組合わせおよび実施する順序等に迷うことが少なくない。本研究では，最近我々が経験した慢性膵炎Ⅰ群116例の診断過程を振り返ることにより，慢性膵炎の診断における理想的な検査法の組合わせとそれぞれの役割を検討し，同時に診断名のみならず病態と病期が容易に理解できる表現方法を提案した。画像診断法，膵外分泌機能検査法（EX），膵内分泌機能検査法（EN）を比較検討し，以下の結果を得た。①画像診断法は必須である。②内視鏡的逆行性膵胆管造影（ERCP）を軸とした腹部超音波検査（US）あるいは腹部CTスキャン（CT）の組合わせは欠くことができない。③EXもまた必須の検査法である。④ENは慢性膵炎の診断に必要不可欠ではないが，治療方針を決めるうえで重要である。⑤純粋膵液（PPJ）の生化学的検査と組織化学的検査は膵炎の診断と病態生理の解明に重要である。⑥PPJ中の細胞診は慢性膵炎に合併した膵癌の検索に有用である。⑦以下に示すような診断の記載方法を提案した。"Calcified chronic pancreatitis, alcoholic, diffuse,　ERCP-3, US-2, CT-3, EX-2, EN-1, Lf(＋)"。 en-copyright= kn-copyright= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=YoshidaMitsuo en-aut-sei=Yoshida en-aut-mei=Mitsuo kn-aut-name=吉田光雄 kn-aut-sei=吉田 kn-aut-mei=光雄 aut-affil-num=6 ORCID= en-aut-name=OkaHiroo en-aut-sei=Oka en-aut-mei=Hiroo kn-aut-name=岡浩郎 kn-aut-sei=岡 kn-aut-mei=浩郎 aut-affil-num=7 ORCID= en-aut-name=MiyakeHirofumi en-aut-sei=Miyake en-aut-mei=Hirofumi kn-aut-name=三宅啓文 kn-aut-sei=三宅 kn-aut-mei=啓文 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=7 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) en-keyword=画像診断 (imaging diagnosis) kn-keyword=画像診断 (imaging diagnosis) en-keyword=PS試験 (pure pancreatic juice) kn-keyword=PS試験 (pure pancreatic juice) en-keyword=純粋膵液(PPJ) (Pancreozymin-Secretin test) kn-keyword=純粋膵液(PPJ) (Pancreozymin-Secretin test) en-keyword=内視鏡的逆行性膵胆管造影(ERCP) (endoscopic retrograde cholangiopancreatography (ERCP)) kn-keyword=内視鏡的逆行性膵胆管造影(ERCP) (endoscopic retrograde cholangiopancreatography (ERCP)) END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=8 article-no= start-page=2783 end-page=2809 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Monocytic Leukemia by Means of Bone-Marrow Tissue Culture Part 3. Clinical Statistics of 30 Cases of Monocytic Leukemia diagnosed by Bone-Marrow Tissue Culture kn-title=骨髓体外組織培養による単球性白血病の研究 第3編 骨髄体外組織培養により診断せし30例の単球性白血病の臨床統計 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the present report the results of the clinical statistcs are presented concerning 30 cases of monocytic leukemia, that were correctly diagnosed by tissue culture of the bone marrow during the past four years from January 1954 to December 1957. Characteristic findings on monocytic leukemia in comparison with other leukemias are as follows: 1. In clinical findings monocytic leukemia presented intermediate characters between those of the acute and the chronic types observable in other leukemias. 2. Monocytic leukemia often demonstrated a tendency to bleed, especially in the mouth, in the early developmental stage of this disease. en-copyright= kn-copyright= en-aut-name=KawanoYoshihiko en-aut-sei=Kawano en-aut-mei=Yoshihiko kn-aut-name=川野嘉彦 kn-aut-sei=川野 kn-aut-mei=嘉彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=2 article-no= start-page=625 end-page=630 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of infectious mononucleosis associated with splenomegaly and leukocytosis which was defficult in making diagnosis kn-title=脾腫・白血球増多症を主徴とし診断に著しく困難を感じた伝染性単核症の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Three years ago the patient was pointed out splenomegaly and leukocytosis associated with no swelling of lymphatic glands after pneumonia, but had no complains till admission's time. Leukocytosis was always counted over 10000, and was occupied indifinite large lymphcytes identified as Downey Ⅱ type cell at 55.6% in maximum of its classification. Bone marrow, red blood cell, reticulocyte and platelets count were normal. Spleenbiopsy showed a full of atypical lymphcytes without leucaemic infiltration in spleen. The infiltration of same atypical lymphcytes with intensely degenerated nature were found by liverbiopsy, and these cells had not any tendency to increase in the liver. Axillary lymphatic gland extirpasion's tissue picture coincided with chronic lymphadenitis, and extensive reticulo-and sinusendotheliar cell increasing were also seen. Several serologic reactions, i.e. Paul-Bunnel reation, Weil-Felix reaction and Davidson's adosorption test had little value to making diagnosis. en-copyright= kn-copyright= en-aut-name=KondoTadasuke en-aut-sei=Kondo en-aut-mei=Tadasuke kn-aut-name=近藤忠亮 kn-aut-sei=近藤 kn-aut-mei=忠亮 aut-affil-num=1 ORCID= en-aut-name=OguchiKiyoshi en-aut-sei=Oguchi en-aut-mei=Kiyoshi kn-aut-name=大口潔 kn-aut-sei=大口 kn-aut-mei=潔 aut-affil-num=2 ORCID= en-aut-name=YamamotoHiroshi en-aut-sei=Yamamoto en-aut-mei=Hiroshi kn-aut-name=山本裕士 kn-aut-sei=山本 kn-aut-mei=裕士 aut-affil-num=3 ORCID= en-aut-name=GotoShoichiro en-aut-sei=Goto en-aut-mei=Shoichiro kn-aut-name=後藤昭一郎 kn-aut-sei=後藤 kn-aut-mei=昭一郎 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=675 end-page=693 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Localization Study of Epileptogenic Focus by Means of Intracarotid Sodium Amobarbital Injection Part 111 Differentiation of Primary and Secondary Bilaterally Synchronous Spike and Wave Complex kn-title=アモバルビタールソーダ頸動脈注射によるてんかん焦点局在診断に関する研究 第3編 1次的及び2次的両側同期性棘徐波複合の鑑別に関する臨床的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Intracarotid injection of 50 to 100 mg of 5 to 10 % sodium amobarbital was given to 30 cases of epileptics, and change of the abnormal EEG was followed. 1) Unilateral focal cortical epileptogenic spikes were abolished by the ipsilateral administration, but not by the contralateral. 2) Amongst the cases of bilaterally synchronous spike and wave complex, two types of marked responses were obtained at the administration. One group manifested an abolishment of the complex from all leads of both hemispheres by administration on one side, but a transient inhibition of the spike component from the ipsilateral hemisphere by administration on the other side. This appears to indicate the complex originates from unilateral cortical focus which is located at the first side. This group may correspond with the secondary bilateral synchrony. 3) Another group manifested a transient inhibition of the spike component from ipsilateral hemisphere without abolishment of the complex at either side of administration. This may correspond with the primary bilateral synchrony, the so-called "ceutrencephalic origin". 4) No activation of characteristic abnormal activities in epileptics was found at the intracarotid injection of sodium amobarbital. en-copyright= kn-copyright= en-aut-name=YagiTakashi en-aut-sei=Yagi en-aut-mei=Takashi kn-aut-name=八木健 kn-aut-sei=八木 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=665 end-page=673 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Localization Study of Epileptogenic Focus by Means of Intracarotid Sodium Amobarbital Injection Part 11 Intracarotid Sodium Amobarbital Injection Effect on Human EEG kn-title=アモバルビタールソーダ頸動脈注射によるてんかん焦点局在診断に関する研究 第2編 アモバルビタールソーダ頸動脈注射の脳波基礎律動に及ぼす影響に関する臨床的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=An attempt was made to analyze the changes of EEG secondary to the intracarotid injection of 50 to 100 mg of sodium amobarbital: 33 trials on 20 patients. 1) There appeared to be a marked change in all cases; limited or dominant ipsilaterally to the side of administration. 2) The latter was found in 22 out of 33 trials, and noted at the records of the frontal leads. 3) The change was composed of high amplitude and low frequency or of low amplitude and high frequency or of the mixed of both, occurring at 3 to 6 seconds after the onset of the injection and gradually disappearing to regain the normal state within 30 minutes. 4) These changes, especially the high amplitude and slow waves immediately after the injection at the same side were markedly noticed when the injection was in large dosage and in high speed. 5) There was no difference in such changes given arise by either side of administration in the same patient. 6) It is to be noted that there were no hazardous complications at the intracarotid injection of 10 % sodium amobarbital under sufficient attention. en-copyright= kn-copyright= en-aut-name=YagiTakeshi en-aut-sei=Yagi en-aut-mei=Takeshi kn-aut-name=八木健 kn-aut-sei=八木 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=649 end-page=663 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Localization Study of Epileptogenic Focus by Means of Intracarotid Sodium Amobarbital Injection Part 1 Intracarotid Sodium Amobarbital Injection Effect on Experimentally Produced Focal Epileptogenic Discharge of Cat kn-title=アモバルビタールソーダ頸動脈注射によるてんかん焦点局在診断に関する研究 第1編 実験的てんかん焦点に対するアモバルビタールソーダ頸動脈注射の影響に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Twenty adult cats were utilized for this study under unanesthetized condition. Penicillin was locally given in various parts of cortex and subcortical nucleus or thalamus to elicit epileptogenic discharges and sodium amobarbital was intracarotidly injected to give arise transient functional depression of hemisphere. EEG was followed up in the course of this experiment. 1) Local application of penicillin into cortex or subcortical nucleus or thalamus considerably elicited epileptogenic discharges. 2) In case of focal cortical epileptogenic discharge, the first spike appearing at the neighbouring area of the focus was followed to be associated with the synchronous spike discharge at the opposite side and then the focal seizure discharge was built. The discharge was occaionally interrupted by the interictal state, building, in some of the cases, the final stage of generalized seizure discharge. 3) So was noted in its appearance and process in case of focal subcortical epileptogenic discharge. But there was a more tendency of transmission of its activity to the opposite side in comparison with the cortical epileptogenic discharge. 4) The epileptogenic discharge originated from unilateral cortical focus was abolished or inhibited by means of ipsilateral intracarotid injection of 5 to 10 mg sodium amobarbital, but was not affected by the contralateral administration. However, either side of the injection could not inhibit the discharge activity after it became a focal seigure discharge. 5) Subcortically elicited epileptogenic discharge, in contrast, could not be interfered by either side of the intracarotid administration. 6) In cases of both focal cortical and subcortical discharge, intracarotid injection of sodium amobarbital manifested a tendency of flattening and slowing of back ground activity at the injected side, but not at the opposide side. 7) The intracarotid administration could not activate the epileptogenic discharges either from cortex and subcortex. en-copyright= kn-copyright= en-aut-name=YagiTakeshi en-aut-sei=Yagi en-aut-mei=Takeshi kn-aut-name=八木健 kn-aut-sei=八木 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=10 article-no= start-page=625 end-page=636 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19641030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Leukemia in the C58 Strain of Mice Part 3. Diagnosis and Differentiation of Mouse Leukemia by the Simplified Tissue Culture Method kn-title=C58マウス白血病の研究 第Ⅲ編 組織培養法による白血病の診断と鑑別 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The simplified tissue culture method and the fluorochrominized tissue culture method devised in our laboratory were applied to the bone marrow, spleen and lymph node of the leukemic mice of C58 strain for the purpose of diagnosis and differentiation of leukemia. And following results were obtained; 1. In the case of spontaneous leukemia, tissue culture of the lymph node and spleen showed sharply defined growth zone with increased cell density which is the characteric pattern of acute leukemia. The bone marrow showed rather diffuse border of growth zone with the appearances of many migrating neutrophiles, but cell density was remarkably increased and many leukemic cells appeared in the growth zone. 2. In the case of myelogenos leukemia, the bone marrow culture showed so-called double growth zone which is characteristic of chronic leukemia. On the other hand, the lymph node and the spleen showed diffuse border of the growth zone with increased cell density. Numerouse immature and mature neutrophilic cells appeared in the growth zone. 3. By the fluorochrominized tissue culture method, the lymph node and the spleen of lymphatic leukemia showed typical lekemic growth zone and gave diffuse yellowish-green color due to the cytoplasmic and nuclcar fluorescence of lymphoblasts and other lymphoid cells. On the other hand, the bone marrow, spleen and lymph node of myelogenous leukemia showed relatively diffuse pattern and the inner part of the growth zone gave greenish fluorescence due to the cytoplasm and nucleus of immature leukemic cell, but in the periphery of the growth zone, reddish-orange color was predominant due to the fluoresceuce of cytoplasmic granules of mature neutrophiles. In conclusion, the lymph node and spleen in lymphatic leukemia and the bone marrow in myelogenous leukemia showed typical leukemic growth zone respectively and these findings are useful for the differential diagnosis of mouse leukemia. en-copyright= kn-copyright= en-aut-name=SuzukiShinya en-aut-sei=Suzuki en-aut-mei=Shinya kn-aut-name=鈴木信也 kn-aut-sei=鈴木 kn-aut-mei=信也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=1-3 article-no= start-page=21 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19640330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Clinical Study of the Mental Disorders in Senility kn-title=老年期精神障害の臨床的研究 en-subtitle= kn-subtitle= en-abstract=The mental disorders of 188 inpatients over the age of 60 are summarized and classified herein. 1) 135 patients over the age of 60 excluding general paresis and alcoholism were studied and classified into six groups in the light of major symptoms. The demented group comprised 23 patients (17%), the manic-depressive, 25 (19%), the paranoid, 23 (17%), the neurotic, 14 (10%), the confused, 14 (10%) and the cerebral arteriosclerotic, 39 (27%). 2) 135 patients (72%) out of 188 had the onset of illness after the age of 60. So did the rest before 60. Approximately one half of the manic-depressive and the paranoid groups had fallen ill before the age of 60, while most of the demented and the confused groups had been taken ill after the age of 60. 3) Dementia was not so marked in the manic-depressive, the paranoid and the neurotic groups. 4) Heredity was suspected to be one of the major predisposing factors more in the manic-depressive and the paranoid groups than in the demented group. 5) Some precipitating factors of their mental disorders were found in all the cases of the confused group, found in one half of the manic-depressive and the neurotic groups, while only few cases had some precipitating factors in the paranoid, the demented and the arteriosclerotic groups. 6) A follow-up study for a year revealed that in the demented group all the cases died or not improved, in the manic-depressive and the neurotic groups, the improved cases were more abundant. In the paranoid group the unimproved rated most in the number and the improved followed them. The duration of the illness in the paranoid tended to be prolonged. In the confused group the dead were the most, lesser proportion remained in remission and none of them stayed stationary in the course of the illness. In the cerebral arteriosclerotic group the improved, the unimproved, the dead shared the same ratio. 7) The subgroups of mental disorders in the old age were surveyed, reviewing corres-ponding literatures. kn-abstract=老年期精神障害の臨床的研究を行い次の結果を得た. 1) 60才以上の入院患者244名中,進行麻痺,アルコール中毒症等と診断されたものを除く135名を主要症候より分類した結果,痴呆群23名(17%)躁うつ群25名(19%)妄想群23名(17%)神経症群14名(10%)錯乱譫妄群14名(10%)脳動脈硬化症群36名(27%)がみられた. 2) 発病年令より分類してみると, 188名中60才以前に発病したものは53名(28%)で60才以後に発病したものは135名(72%)で,病型別にみると躁うつ群,妄想群は約半数が60才以前に発病し,痴呆群,錯乱譫妄群は大部分が60才以後に発病していた. 3) 痴呆程度は躁うつ群,妄想群,神経症群では軽度にしか認められなかつた. 4) 遺伝負因は不明者が多く確実なことは分らなかつたが,躁うつ群,妄想群に痴呆群よりよく認められる様である. 5) 発病に対する直接的誘因は錯乱譫妄群で全例,躁うつ群,神経症群では約半数に認められたが,妄想群,痴呆群,脳動脈硬化症群では僅かしか認められなかつた. 6) 入院1年後の転帰は痴呆群では死亡,未治が全てで,軽快したものは1名もなく,躁うつ群,神経症群では軽快が多く未治がそれに次ぎ,妄想群では未治が一番多く次に軽快が多く,経過が長びく傾向にあり,錯乱譫妄群では死亡に次いで寛解が多く未治は全然なく患者は死亡もしくは寛解し,脳動脈硬化症群では軽決, 未治,死亡が大体同じ割合に認められた. 7) 錯乱譫妄群14名中8名は症候性精神病で,6名は心因により精神異常を示したもので症例を挙げ検討した. 8) 以上の各群について文献を挙げて考察を行い,症候性精神病を中心として鑑別診断についても述べた. en-copyright= kn-copyright= en-aut-name=HiramatsuTadashi en-aut-sei=Hiramatsu en-aut-mei=Tadashi kn-aut-name=平松直 kn-aut-sei=平松 kn-aut-mei=直 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=2 article-no= start-page=389 end-page=395 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Application of Ultrasonics to Medical Diagnostic Method Part 3. Transorbital Ultrasonic Examination kn-title=医学的診断領域における超音波に関する研究 第3編 超音波による後頭蓋窩疾患の診断方法に関する基礎的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Transorbital ultrasonic examination was deviced by the anthor. The echo from the IVth ventricle were obtained by using this method. In order to record normal echo-gram, the probe (1MC or 2.25MC) was placed directly on the upper eyelid and the echos from the orbit, pyramid, IVth ventricle and occipital bone were recorded by this method. Clinically, this method would be applied to diagnosis of the infratentorial tumors. Abnormal echos would be obtained between the echos from the pyramid and the occipital bone on the side of tumor or the echo of the displaced IVth ventricle would be obtained. en-copyright= kn-copyright= en-aut-name=SadamotoKazuhiko en-aut-sei=Sadamoto en-aut-mei=Kazuhiko kn-aut-name=貞本和彦 kn-aut-sei=貞本 kn-aut-mei=和彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=2 article-no= start-page=379 end-page=388 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Application of Ultrasonics to Medical Diagnostic Method Part 2. Application of Ultrasonic Probe to Diagnosis of Diestive Organs kn-title=医学的診断領域における超音波に関する研究 第2編 消化管内よりの超音波診断方法に関する基礎的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=New application method of ultrasonic probe to diagnosis of digestive organs was deviced by the author. The special ultrasonic probes for this study have been designed and producel by the author. Transdnsducers with barium titanate ceramic vibrator (2.25MC) and 10mm or 7mm in diameter have been used at the tip of the flexible probes. Probes are 2～3m in length and 5mm in diameter and can be rotate in all directions in the oesophagus, stomach, rectum and discending colon. Clinically, digestive organs would be examined by transoral or transanal application of these probes. In the experimental and clinical studies, the ethos from the vagus, heart and mediastinum were obtained from the probe which was located in the oesophagus: the echos from the liver, gall bladder, diaphragm, pancreas, spleen and retroperitoneum were obtained from the probe which was located in the stomach; the echo from the urinary bladder, small intestine and kidney were obtained from the probe which was located in the descending colon. In the clinical studies, the echos from the heart, aorta and inferier vena cava showed pulsating, fine and multiple wave form; the echos from the cancer tissues, scharp and multiple wave form; the echo from the diaphragm, sharp wave form and movable by respiration. en-copyright= kn-copyright= en-aut-name=SadamotoKazuhiko en-aut-sei=Sadamoto en-aut-mei=Kazuhiko kn-aut-name=貞本和彦 kn-aut-sei=貞本 kn-aut-mei=和彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=2 article-no= start-page=369 end-page=377 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Application of Ultrasonics to Medical Diagnastic Method Part 1. Fundamental Study on Medical Application of Ultrasonics kn-title=医学的診断領域における超音波に関する研究 第1編 超音波の医学的応用に関する諸問題 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The application of ultrasonics to medical diagnostic method has not been so much successful, because the complexity of the sound reflecting structures echos which are so numerous and variable that controlled experiments and consistent results are difficult to obtain. In this point, fundamental electrical and ultrasonic study in medicine has been very important; electrical circuit of the pulse generater, receiver, amplifier and indicator, pulse length and intensity of the transmitter, the directibility of the ultrasonic beam and scanning mehtod, they would be concerned with upper problem. A new type of apparatus for this study has been designed and produced by the author; Sensitivity of the recciver is 90～100 dB, measuring distance is 2mm～1.8m and the freguency of the pulse generator is 0.5MC～10MC. A 500pF capactior is charged to about 1,800 V through a high resistance and is then discharged by a thyratron tube (3C45) through the primary winding of a pulse transformer. The amplitude of the transmited ultrasonic pulse rises from lμs to its maximum value in 20μs. Fifty or sixty such pulses are transmited each secound to human body. This apparatus has been used to diagnostic medicine and fundamental study in the author's clinic. en-copyright= kn-copyright= en-aut-name=SadamotoKazuhiko en-aut-sei=Sadamoto en-aut-mei=Kazuhiko kn-aut-name=貞本和彦 kn-aut-sei=貞本 kn-aut-mei=和彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=11-12 article-no= start-page=1081 end-page=1090 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19681230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Ultrasonic Diagnosis in Surgery Part 2. Ultrasonic Diagnosis of Liver Disease Combinating with Colloidal Au(193) Hepatoscintigram & Using the Ultrasonic Contact Compound Scope kn-title=外科領域における超音波診断に関する研究 第2編 超音波による肝腫瘍診断に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The high request of the preoperative diagnosis for liver metastasis of cancer is the claimed factor in the surgical field. Many kinds of examinations; i. e, physical examination, liver function test of serum, liver biopsy, laparoscopy, roentogenological diagnosis and others were using for this purpose, but the diagnosis was unliable yet. Recently, the clinical application of radioisotope is remarkably advanced, and the scintiscanning is used as a standard tool for clinician. The advances of the ultrasonic diagnostic apparatus and techniques is also evident. In this paper the investigations were carried out by combinating method of ultrasonic diagnosis with hepatoscintigram. The excellent point of this method is to improve the weak points each other of the hepatoscintigram and ultrasonic diagnosis. By means of hepatoscintigram every large space occupying lesion (more than 2-3cm in diameter) in liver can be seen but the depth and structure of the lesion can not be recognized, however the ultrasonic A-scope method is able to clarify the laters. Ultrasonic method is able to diagnose the character of the aimed occupying lesion, respectively. Generally, the continuous multiplying echo indicate the cancer tissue, the boundary wall echo is the cyst or abscess, and the gall stone is easily diagnosed at the same time. But the risk for over diagnosis is respective in two methods, the diagnosis by this combinating method must be carefull in considerations. Combinating method of ultrasonic A-scope with hepatoscintigram gave a good result for liver disease. But the nature of the echoes obtained various kind of livers tend to over-lap. Therefore it is difficult to remark the distinguished accuracy in all cases. The suitable frequency was 2.25MC and a barium titanate of 10mm in diameter was used. Now we are using the ultrasonic contact compound scope, Aloka SSD-10. In this paper some results and problems of this method were presented. The examination is carried out at the lower right chest wall or through the abdominal wall. Several normal human livers were examined first. Some echograms of them were shown. Details of the deep structure are shown when STC (Sensitivity Time Control) is on. But concerning intrahepatic structure, it demonstrates more clearly than when STC off. Some echo patterns of the metastatic liver cancers were shown. A patient who had alarge tumor at his upper right abdomen was examined. His echogram of liver is shown. There is a large tumor (4cm in diameter) at the deep region in liver and the back surface of liver is pressured backwards. But no malignant echo pattern is seen. In some cases of our examinations malignant tissues showed only the surface and bottom echoes. The result of operation actually showed the metastatic cancer of liver, corresponding with the echogram. This fact suggests there are various degrees of absorption of ultrasound among cancers. en-copyright= kn-copyright= en-aut-name=ChikubaHiroshi en-aut-sei=Chikuba en-aut-mei=Hiroshi kn-aut-name=竹馬浩 kn-aut-sei=竹馬 kn-aut-mei=浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科教室 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=11-12 article-no= start-page=1071 end-page=1080 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19681230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Ultrasonic Diagnosis in Surgery Part 1. Ultrasonic Examination of Intracerebral Destructive Lesion in Stereotaxic Surgery kn-title=外科領域における超音波診断に関する研究 第1編 定位脳手術破壊巣の超音波診断に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Stereotaxic thalamic lesions by electrocoagulation have been produced on sixty four cases of extrapyramidal disorders by means of newly deviced simple electrocoagulation probe, which is made of 300mm of straight steel wire with one millimeter in diameter covered loosely by 293mm of hard teflon pipe as insulation to electricity and the local heat. The probe, therefore, has retractable 7mm bare tip, so it can be safely withdrawn without any, danger from hemorrhage of destructed tissue after coagulation. As a preliminary experiment, stereotaxic thalamic lesions by the probe have been produced in the dog brain as well as the formalin suspended human brains under observation with ultrasonic A-scope apparatus by reflection method. The transducer provided with barium titanate (2.25 Mc, 10mm diameter) was used. It was clearly identified that the echoes were corresponded to size and location of the lesions in the dog brain as well as human brain specimen. During the surgery, echo was noted from the tip of probe which was in the target area of the thalamus of the patients. In every case, the lesion echoes showed high fluctuating amplitude and width during coagulation procedure. Lesion echoes were observed up to 45 days after the surgery. They maintained stable duplicate echoes during the period. It is our suggestion that the ultrasonic examination of the stereotaxic lesion is useful to note accidental hemorrhage in the lesion of a reconvalescent patient. It is also a great aid for this purpose to check the midline echo at the same time. Recently further investigations with ultrasonic compound sector scope, Aloka SSD-10, were done. The ultrasonic scanning was performed on the operative side vertically. During and after the coagulation of the target, twenty three cases were examined with compound sector scope. The reflextion from the lesion with compound scope was noted in 91.3% of the cases while 82.9% with A-scope. The lesionecho was obtained about 1.4cm lateral from the midline echo in case of destruction of V.L. nucleous of the thalamus. In case of the centre median the lesionecho was located adjacent to the midline echo. These lesionechoes were located correctly in their anatomical coordinates of the targets. But the size and shape of the lesionechoes were identified rather larger than the destructed lesions. This deflexion would be due to the width of the ultrasonic reflected wave. As confirmative experiments, stereotaxic thalamic destructive lesions have been produced in the specimen of the formalin suspended human brains under observation with ultrasonic compound sector scope. It is our impression that echo-encephalgraphy with the ultrasonic compound scope has a potential usefulness to observe location, shape and size of the lesion as well as to detect the accidental hemorrhage of a reconvalescent patient. en-copyright= kn-copyright= en-aut-name=ChikubaHiroshi en-aut-sei=Chikuba en-aut-mei=Hiroshi kn-aut-name=竹馬浩 kn-aut-sei=竹馬 kn-aut-mei=浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=9-10 article-no= start-page=421 end-page=429 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19701030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical observations of albuminuria in students discovered by periodical examination in Okayama University for 4 years kn-title=岡山大学々生の定期健康診断における尿蛋白陽性者の経年的観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=One of the most difficult problem in clinical diagnosis is to differenciate albuminuria found in urine by mass-examination, especially on the point of harmlos albuminuria or renal diseases. Total 13,304 cases including 5,037 female students were examined in every years during 1967 to 1970. Albuminuria was found in 561 cases including 141 female cases, its total percentage in 4 years was 4.21% ranging from 1.86% to 5.80% in each year. Re-examinations were done in 320 cases of this group with 98 female cases, including anamnesis, urinalyses, blood pressure measument, PSP test, total serum protein & A/G ratio, ASLO, serum chloeserol, blood urea nitrogen and hematotrit. Albuminuria was ranged from 20.3% to 48.5% and 32.1% in average. Microhemauria and abnormal casts were found in 35.1% and 31.7% in avarage, respectively. Most cases of micro hematuria and abnormal casts were observed every times in the same cases, and about a half of negative cases of them became positive at the next examination. Decreased value of PSP excretion at 15 minutes and at 120 minutes were found in 10.8% and 5.7%, respectively. Decreasing tendency of PSP excretion at 15 minutes in the second examination was found in 5.5% . Low hematocrit value was revealed in the range of 1.9% to 7.3% and 4.6% in average. Abnormality of ASLO value was found in the range of 2.9% to 13.3% and 9.4% in average. High serum cholesterol value observed in the group was ranged from 3.3% to 9.0% and 6.1% in average. Abnormal cases in serum total protein and A/G ratio were 12.4% and 9.8% in average, respectively. Hypertension was found to be 5.8% in average in the maxium blood pressure: and 6.9% in average in the minimum. 42.9% of examined cases had no paticular anmnesis: and 29.0% of the cases had the history of chronic tonsillitis, 12.0% of them had renal diseases, and 11.1% of then had toothcaries. No sexual differences were observed statistically in each items of the examination. Diagnosis established in 126 cases were 36 cases of nephritis, 10 cases of essential hypertension, 16 cases of anemia and 17 cases of transient albuminuria. According to the results, it is difficult to prognose albuminuria during such a short period, but it is the most important thing to establish the diagnosis through the process of repeated urinalysis. en-copyright= kn-copyright= en-aut-name=KondoTadasuke en-aut-sei=Kondo en-aut-mei=Tadasuke kn-aut-name=近藤忠亮 kn-aut-sei=近藤 kn-aut-mei=忠亮 aut-affil-num=1 ORCID= en-aut-name=KawaiToshio en-aut-sei=Kawai en-aut-mei=Toshio kn-aut-name=河合利夫 kn-aut-sei=河合 kn-aut-mei=利夫 aut-affil-num=2 ORCID= en-aut-name=YamamotoTakehiko en-aut-sei=Yamamoto en-aut-mei=Takehiko kn-aut-name=山本武彦 kn-aut-sei=山本 kn-aut-mei=武彦 aut-affil-num=3 ORCID= en-aut-name=IzawaTetsuichi en-aut-sei=Izawa en-aut-mei=Tetsuichi kn-aut-name=井沢徹一 kn-aut-sei=井沢 kn-aut-mei=徹一 aut-affil-num=4 ORCID= en-aut-name=YamabukiTakahiro en-aut-sei=Yamabuki en-aut-mei=Takahiro kn-aut-name=山吹隆寛 kn-aut-sei=山吹 kn-aut-mei=隆寛 aut-affil-num=5 ORCID= en-aut-name=TakanoToshio en-aut-sei=Takano en-aut-mei=Toshio kn-aut-name=高野俊男 kn-aut-sei=高野 kn-aut-mei=俊男 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部小坂内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部小坂内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部小坂内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部小坂内科教室 affil-num=5 en-affil= kn-affil=岡山大学保健管理センター affil-num=6 en-affil= kn-affil=岡山大学保健管理センター END start-ver=1.4 cd-journal=joma no-vol=84 cd-vols= no-issue=11-12 article-no= start-page=455 end-page=459 dt-received= dt-revised= dt-accepted= dt-pub-year=1972 dt-pub=19721230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagnostic evaluation for gynecologic tumor with ultrasonic tomography. - with special reference to ovarian tumor kn-title=婦人科腫瘍に対する超音波断層法の診断的価値―特に卵巣腫瘍について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Diagnostic value for ovarian tumor with Contact Compound Scope of the ultrasonic tomography is discussed. The size and localization of the tumor are relatively easy to determin with ultrasonic equipment but characteristics of the tumor, particularly benign or maligmant, has not been clarified. In this paper, tomographic patterns of vorious solid (Cystoadenocarcinoma, Granulosa cell tumor and Dysgerminoma) and cystic (Cystoadenoma and Dermoid cyst) tumors are demonstrated. Differential diagnosis to determin malignant or not was still difficult to obtain conclusive result but it was possible to diagnose solid one or not by the method. en-copyright= kn-copyright= en-aut-name=SekibaKaoru en-aut-sei=Sekiba en-aut-mei=Kaoru kn-aut-name=関場香 kn-aut-sei=関場 kn-aut-mei=香 aut-affil-num=1 ORCID= en-aut-name=KobayashiSumio en-aut-sei=Kobayashi en-aut-mei=Sumio kn-aut-name=小林純郎 kn-aut-sei=小林 kn-aut-mei=純郎 aut-affil-num=2 ORCID= en-aut-name=UnoAkira en-aut-sei=Uno en-aut-mei=Akira kn-aut-name=宇野昭 kn-aut-sei=宇野 kn-aut-mei=昭 aut-affil-num=3 ORCID= en-aut-name=MatsuokaMichiya en-aut-sei=Matsuoka en-aut-mei=Michiya kn-aut-name=松岡道也 kn-aut-sei=松岡 kn-aut-mei=道也 aut-affil-num=4 ORCID= en-aut-name=AkiyamaJitsuo en-aut-sei=Akiyama en-aut-mei=Jitsuo kn-aut-name=秋山実男 kn-aut-sei=秋山 kn-aut-mei=実男 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産婦人科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部産婦人科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部産婦人科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部産婦人科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部産婦人科教室 END start-ver=1.4 cd-journal=joma no-vol=86 cd-vols= no-issue=5-6 article-no= start-page=221 end-page=229 dt-received= dt-revised= dt-accepted= dt-pub-year=1974 dt-pub=19740630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagnosis of Pancreatic Diseases by Scintigraphy kn-title=膵臓シンチグラフィーによる膵疾患の診断 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With 63 cases on whom we performed the scintigraphy of pancreatic diseases, we studied the possiblity of differential diagnosis and oter points relevant to the diagnosis in this disease group by comparing retrospectively clinical findings with postoperative findings of these cases, and arrived at the conclusions as follows: 1) For the scintigraphy of pancreas, scinticamera is excellent, and it is especially useful to take consecutive pictures at intervals of 10 minutes each for one hour with this camera after injecting (75)Se-methionine. 2) The major cases of the pancreas that gives normal visualization can be considered as normal, but as normal pictures can be obtained even in the cases of chronic pancreatitis. There are some cases where differential diagnosis between the two disease groups is difficult by scintigraphic finding. 3) In the case of a focal decrease of uptake first of all cancer can be suspected. However, there are cases where differentiation from chronic pancreatitis is difficult. In such instances, about half of the cases demonstrating roentgenologically calcification proves to be of chronic, calcified pancreatitis, but excluding these cases the percentage of cancer cases is high. 4) Among those cases showing pancreas in scintigram faint or nonvisible, there were two cases out of 3 where chronic pancreatitis was complicated with calcification. Excluding the two cases, cancer occupies a decidedly high percentage, and the cancer is mostly located around the head of pancreas, indicating that pathologic changes have invaded main pancreatic ducts. 5) There were 7 cases of chronic, calcified pancreatitis, one case giving normal pancreatitis, one case giving normal scitigraphic findings, 4 cases a focal decrease of uptake, and two cases showing the pancreas faint or nonvisible. en-copyright= kn-copyright= en-aut-name=TanabeMasatada en-aut-sei=Tanabe en-aut-mei=Masatada kn-aut-name=田辺正忠 kn-aut-sei=田辺 kn-aut-mei=正忠 aut-affil-num=1 ORCID= en-aut-name=TamaiToyosato en-aut-sei=Tamai en-aut-mei=Toyosato kn-aut-name=玉井豊理 kn-aut-sei=玉井 kn-aut-mei=豊理 aut-affil-num=2 ORCID= en-aut-name=HirakiYoshio en-aut-sei=Hiraki en-aut-mei=Yoshio kn-aut-name=平木祥夫 kn-aut-sei=平木 kn-aut-mei=祥夫 aut-affil-num=3 ORCID= en-aut-name=EharaKazuhiko en-aut-sei=Ehara en-aut-mei=Kazuhiko kn-aut-name=江原一彦 kn-aut-sei=江原 kn-aut-mei=一彦 aut-affil-num=4 ORCID= en-aut-name=TakagiHisao en-aut-sei=Takagi en-aut-mei=Hisao kn-aut-name=高木寿生 kn-aut-sei=高木 kn-aut-mei=寿生 aut-affil-num=5 ORCID= en-aut-name=HaisaYoshio en-aut-sei=Haisa en-aut-mei=Yoshio kn-aut-name=羽井佐芳雄 kn-aut-sei=羽井佐 kn-aut-mei=芳雄 aut-affil-num=6 ORCID= en-aut-name=KumadaYasumasa en-aut-sei=Kumada en-aut-mei=Yasumasa kn-aut-name=久万田泰昌 kn-aut-sei=久万田 kn-aut-mei=泰昌 aut-affil-num=7 ORCID= en-aut-name=WakabayashiHiroshi en-aut-sei=Wakabayashi en-aut-mei=Hiroshi kn-aut-name=若林弘 kn-aut-sei=若林 kn-aut-mei=弘 aut-affil-num=8 ORCID= en-aut-name=HashimotoGonosuke en-aut-sei=Hashimoto en-aut-mei=Gonosuke kn-aut-name=橋本郷之介 kn-aut-sei=橋本 kn-aut-mei=郷之介 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=86 cd-vols= no-issue=1-2 article-no= start-page=87 end-page=93 dt-received= dt-revised= dt-accepted= dt-pub-year=1974 dt-pub=19740228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on the pattern of urinary protein excretion of college student discovered proteinuria by periodical examination kn-title=定期健康診断における尿蛋白陽性者の尿蛋白排泄patternによる検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Sixty-eight of Okayama university students who discovered by periodical examination was investigated by five urine specimen method, and classified in nine groups by the pattern of proteinuria. Simultaneously, past history, urinary sediment, hematocrit, PSP, Urea-N and total serum protein was investigated and comparative studies among each group was studied. Percentage of positive proteinuria discovered by two urine specimen examination (before bed and early morning) and three urine specimen examination (on arrival, one hour rest and two hours rest) was not coincided, so these results suggest the more urine examination make the better discovery of proteinuria, because intermitent proteinuria was 27.4% who showed negative urinary protein on the examined day. Type of urinary protein excretion pattern was classified as follows; proteinuria was negative both at before bed and in the early morning (a), positive urinary protein at before bed and negative in the early morning (b), urinary protein showed positive both at before bed and in the early morning (c): proteinuria was negative on arrival at health service center, after one hour rest, and after two hours rest, intermitent type (A), urinary protein changed from positive to negative by rest, positional type (B), and always positive urinary protein, persistent type (C). Nine groups was made by the combination of these types. Ditribution of groups was 27.9% (a-A group), 17.6% (b-B group), 14.7% (c-C group) and 0% (a-C group). Incidence of red blood cell in the urinary sediment in each group was under five red blood cell count in one high power field in negative group, and microhematuria was found in five of ten cases of persistent type and three of them showed over six blood cell count in one high power fieldIncidence of renal diseases in past hisotry decreased in the order of persistent type, positional type and intermitent type of proteinuria. High ASLO titer was found in over half cases of positional type and ASLO titer & proteinuria was decreased after administration of antibiotics (Sigmamicin). Possibility of infection influenced on the proteinuria of positional type was suspected. Results of PSP, Urea-N, Cholesterol, total protein and A/G ratio were in normal range and no signifficant difference among each group. Histological findings by renal biopsy from three cases of persistent type elucidated the presence of renal diseases. According to the results, examination of five urine specimen, past history, urinary sediment (red blood cell count) and ASLO was the important items of the examination of proteinuria discoverd by perioidical examination of college student. en-copyright= kn-copyright= en-aut-name=HirohataMamoru en-aut-sei=Hirohata en-aut-mei=Mamoru kn-aut-name=広畑衛 kn-aut-sei=広畑 kn-aut-mei=衛 aut-affil-num=1 ORCID= en-aut-name=WatanabeYutaka en-aut-sei=Watanabe en-aut-mei=Yutaka kn-aut-name=渡部寛 kn-aut-sei=渡部 kn-aut-mei=寛 aut-affil-num=2 ORCID= en-aut-name=MiyoshiKanji en-aut-sei=Miyoshi en-aut-mei=Kanji kn-aut-name=三好莞爾 kn-aut-sei=三好 kn-aut-mei=莞爾 aut-affil-num=3 ORCID= en-aut-name=NishiharaTakao en-aut-sei=Nishihara en-aut-mei=Takao kn-aut-name=西原孝雄 kn-aut-sei=西原 kn-aut-mei=孝雄 aut-affil-num=4 ORCID= en-aut-name=SeoKenji en-aut-sei=Seo en-aut-mei=Kenji kn-aut-name=瀬尾憲司 kn-aut-sei=瀬尾 kn-aut-mei=憲司 aut-affil-num=5 ORCID= en-aut-name=KondoTadasuke en-aut-sei=Kondo en-aut-mei=Tadasuke kn-aut-name=近藤忠亮 kn-aut-sei=近藤 kn-aut-mei=忠亮 aut-affil-num=6 ORCID= en-aut-name=YamabukiTakahiro en-aut-sei=Yamabuki en-aut-mei=Takahiro kn-aut-name=山吹隆寛 kn-aut-sei=山吹 kn-aut-mei=隆寛 aut-affil-num=7 ORCID= en-aut-name=TakanoTosio en-aut-sei=Takano en-aut-mei=Tosio kn-aut-name=高野俊男 kn-aut-sei=高野 kn-aut-mei=俊男 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=7 en-affil= kn-affil=岡山大学保健管理センター affil-num=8 en-affil= kn-affil=岡山大学保健管理センター END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=3-4 article-no= start-page=285 end-page=295 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagnosis of Primary Hepatocellular Carcinoma by Means of the Serial Estimation of Serum α-Fetoprotein Concentration and Computer Scintigraphy kn-title=血清α-Fetoprotein濃度上昇の臨床的意義に関する研究 第2編 Computer Scintigram及びα-Fetoproteinの肝癌診断への応用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Twenty two cases with primary hepatocellular carcinoma, 6 cases with cholangiocellular carcinoma and 12 cases with metastatic liver cancer were examined by scintiphotography using scintillation camera with (99m)Tc radio colloid ((99m)Tc-sulfur colloid, (99m)Tc-staneous colloid or (99m)Tc-phytate) and (67)Ga-citrate or (67)Ga-malate. In addition to the conventional analysis of hepatic scintiphotography, the data were also fed into computer system and stored in the memory (64×64 memory). Application of Fourier transforms and the interative approximation according to Iinuma's method to the averaged matrix data were performed to restore true information of hepatic image. The subtraction scintigram was obtained by subtracting (99m)Tc activity from (67)Ga activity in each matrix data treated with computer focusing. Twenty of 22 cases of patients with hepatocellular carcinoma were diagnosed by liver by liver scintiphotography with (99m)Tc radio colloid, but one of 2 cases undetectable on conventional scintigram. In the remaining one case, diagnosis was accomplished by continuous increase of serum α-fetoprotein. One case of metastatic liver cancer invisible on conventional scintiphotography were diagnosed by means of computer scintigraphy and subtraction scintigraphy. This is indicated that more cases of hepatic carcinoma can be deagnosed by the application of serial determination of serum α-fetoprotein, computer scintigraphy and subtraction scintigraphy simultaneously. en-copyright= kn-copyright= en-aut-name=TanakaYoshikiyo en-aut-sei=Tanaka en-aut-mei=Yoshikiyo kn-aut-name=田中義淳 kn-aut-sei=田中 kn-aut-mei=義淳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=3-4 article-no= start-page=177 end-page=183 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagnosis and treatment of acute rejection after kidney homotransplantation in dog Part 2. Correlation between the effect of a large dose of methylprednisolone administration and the finding of transplanted kidney tissue kn-title=犬同種腎移植後の急性拒絶反応に対する診断と治療に関する研究 第2編 メチルプレドニン大量投与の効果と移植腎組織所見の相関について en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the acute rejection after kidney homotransplantation in dogs when 20 mg/kg/day of MPSS (methylprednisolone) had been administered for 3 days, serum creatinine recovered from 3.4 mg/dl to 2.4 mg/dl, and the rejection was successfully inhibited in 13 cases (93%) out of 14. By histological findings 4 out of 6 cases showed a marked improvement of cell infiltration, 2 cases a slight improvement, and there was not a single case showing any increase of cell infiltration. As the complication of MPSS administration, there could be observed pneumonia and hemorrhage in the upper alimentary canal. Pneumonia occurred in 4 cases (29%) out of 14, of them 3 cases (21%) died from pneumonia. Hemorrhage in the upper alimentary canal was observed in 2 cases (14%) of the 14 studied. en-copyright= kn-copyright= en-aut-name=TanakaKohki en-aut-sei=Tanaka en-aut-mei=Kohki kn-aut-name=田中浩毅 kn-aut-sei=田中 kn-aut-mei=浩毅 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科教室 END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=3-4 article-no= start-page=169 end-page=176 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagnosis and treatment of acute rejection after kidney homotransplantation in dog Part 1. Clinical results and change of macrophage migration inhibition activity at the administration of methylprednisolone in a large dose kn-title=犬同種腎移植後の急性拒絶反応に対する診断と治療に関する研究 第1編 メチルプレドニン大量投与時の臨床検査成績とマクロファージ遊走阻止活性の推移について en-subtitle= kn-subtitle= en-abstract= kn-abstract=After kidney homotransplantation in dogs we pursued daily the macrophage migration inhibitory (MI) activity, which is one of the diagnostic parameters, and obtained the following results. At the time when it was diagnosed to have an acute rejection from routine clinical findings in the untreated control group, MI-activity was positive in 77% of the cases. The MI-activity was positive in 65% already 36 hours prior to the diagnosis was clinicaly made as of acute rejection case. With the test group treated with MPSS (methylprednisolone) MI-activity was positive in 75% of the cases at the time when diagnosed as of acute rejection. In 6 cases (43%) out of 14 the MI-activity was positive 48 hours prior to the diagnoses of acute rejection. When 20 mg/kg/day of MPSS was injected intravenously to 14 cases that had shown acute rejection despite Imuran administration for 3 consecutive days, serum creatinine decreased from 3.4 mg/dl to 2.4 mg/dl, urine excretion increased, and MI-activity also recovered to the normal range from 75% to 94% by a significant difference (P<0.001). These findings seem to indicate that the macrophage migration inhibitory activity test after kidney transplantation is not only an effective, immunological diagnosis to assess the acute rejection after kidney transplantation but also useful in determining the effect of immunosuppression. en-copyright= kn-copyright= en-aut-name=TanakaKohki en-aut-sei=Tanaka en-aut-mei=Kohki kn-aut-name=田中浩毅 kn-aut-sei=田中 kn-aut-mei=浩毅 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科教室 END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=1-2 article-no= start-page=9 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on lung cancer -Recent progress in diagnosis and therapy- kn-title=肺癌の診断並びに治療に関する研究―最近の進歩を中心に en-subtitle= kn-subtitle= en-abstract= kn-abstract=Mass X-ray surveys for detecting lung cancer were conducted by our research group since 1967. Thirty-two cases of lung cancer (16.5/100,000) were detected in 1973 and 56 cases (24.4/100,000) in 1974. Chemotherapeutic effects were examined on 167 lung cancer cases from our hospital records from 1963 to 1973. The effective cases of chemotherapy apparently survived longer compared with ineffective cases. Cases after 1969 with sufficient chemotherapy were reviewed for survival compared to cases before 1968. Our combined FOBEM therapy (5FU, vincristine, Bleomycin, cyclophosphamide and Mitomycin C) showed a high percentage of survival in comparison with the earlier single-agent administration. In lung cancer patients the FOBEM protocol or Ifosfamide massive intermittent therapy is recommended. The use of either of these two methods resulted in higher survival of small cell cancer cases compared to cases treated prior to FOBEM treatment. Patients on chemotherapy combined with radiotherapy survived longer compared to patients on chemotherapy alone. Survival of lung cancer patients was prolonged by immuno-chemotherapy with a streptococcal agent. en-copyright= kn-copyright= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=90 cd-vols= no-issue=9-10 article-no= start-page=1157 end-page=1163 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19781030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagnosis of heart disease using by RI angio cardiography Part Ⅲ. Cases of left to right shunts kn-title=RI Angiocardiographyによる心疾患の診断 第3編 左-右シャント症例について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Count ratio (C(2)/C(1)) technique for detection of left to right shunts by radionuclide was performed. Count ratio technique of ASD cases accurately detected shunts and could reliably separate from normals, but there were a few false positive in patients with ventricle septal defect. There was no correlation between C(2)/C(1) ratio and oximetry. Postoperatively, C(2)/C(1) ratios of ASD cases were resumed to normal or close to normal but some cases of VSD were not returned to normal. en-copyright= kn-copyright= en-aut-name=TanabeMasatada en-aut-sei=Tanabe en-aut-mei=Masatada kn-aut-name=田辺正忠 kn-aut-sei=田辺 kn-aut-mei=正忠 aut-affil-num=1 ORCID= en-aut-name=TamaiToyosato en-aut-sei=Tamai en-aut-mei=Toyosato kn-aut-name=玉井豊理 kn-aut-sei=玉井 kn-aut-mei=豊理 aut-affil-num=2 ORCID= en-aut-name=KawaseEtsuo en-aut-sei=Kawase en-aut-mei=Etsuo kn-aut-name=川瀬悦郎 kn-aut-sei=川瀬 kn-aut-mei=悦郎 aut-affil-num=3 ORCID= en-aut-name=TakakiHisao en-aut-sei=Takaki en-aut-mei=Hisao kn-aut-name=高木寿生 kn-aut-sei=高木 kn-aut-mei=寿生 aut-affil-num=4 ORCID= en-aut-name=MizukawaKiichiro en-aut-sei=Mizukawa en-aut-mei=Kiichiro kn-aut-name=水川帰一郎 kn-aut-sei=水川 kn-aut-mei=帰一郎 aut-affil-num=5 ORCID= en-aut-name=MorimotoSetsuo en-aut-sei=Morimoto en-aut-mei=Setsuo kn-aut-name=森本節夫 kn-aut-sei=森本 kn-aut-mei=節夫 aut-affil-num=6 ORCID= en-aut-name=HashimotoKeiji en-aut-sei=Hashimoto en-aut-mei=Keiji kn-aut-name=橋本啓二 kn-aut-sei=橋本 kn-aut-mei=啓二 aut-affil-num=7 ORCID= en-aut-name=SatoKatashi en-aut-sei=Sato en-aut-mei=Katashi kn-aut-name=佐藤功 kn-aut-sei=佐藤 kn-aut-mei=功 aut-affil-num=8 ORCID= en-aut-name=HirakiYoshio en-aut-sei=Hiraki en-aut-mei=Yoshio kn-aut-name=平木祥夫 kn-aut-sei=平木 kn-aut-mei=祥夫 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大孝医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大孝医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大孝医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大孝医学部放射線医学教室 affil-num=5 en-affil= kn-affil=岡山大孝医学部放射線医学教室 affil-num=6 en-affil= kn-affil=岡山大孝医学部放射線医学教室 affil-num=7 en-affil= kn-affil=岡山大孝医学部放射線医学教室 affil-num=8 en-affil= kn-affil=岡山大孝医学部放射線医学教室 affil-num=9 en-affil= kn-affil=岡山大孝医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=90 cd-vols= no-issue=9-10 article-no= start-page=1145 end-page=1149 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19781030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagnosis of heart disease using by RI angiocardiography Part Ⅱ. Mitral valve disease kn-title=RI angio-cordiographyによる心疾患の診断 第2編 僧帽弁疾患症例を中心として en-subtitle= kn-subtitle= en-abstract=This report represents an extension of our use of a Scintillation (Anger) camera with computer processing (Toshiba DAP 5000-2) of data for evaluation of mitral valve disease (11 cases). For these studies we have administered 10 mCi of (99m)Tc intravenously and have followed its passage through the heart and lung using techniques for data acquisition: a 35 mm camera, a video tape system for data storage and replay for computer analysis using a DAP 5000-2. RI dilution curves recorded on the right ventricle, the left lung and the left ventricle were analyzed to obtain following parameters, namely interventricular peak to peak time, C(2)/C(1) ratio of each dilution curves. These data showed following: 1) Interventricular peak to peak time normal group (12 cases): 6.40 ± 1.18 seconds mitral valve disease (11 cases): 11.34 ± 3.69 seconds 2) a) C(2)/C(1) ratio of the right ventricle normal group: 0.45 ± 0.08 seconds mitral valve disease: 0.58 ± 0.17 seconds b) C(2)/C(1) ratio of the left ventricle normal group: 0.38 ± 0.09 seconds mitral valve disease: 0.49 ± 0.11 seconds c) C(2)/C(1) ratio of the left lung normal group: 0.45 ± 0.08 seconds mitral valve disease: 0.50 ± 0.12 seconds kn-abstract=心疾患を有する患者では,その循環動態は種々の因子により容易に変化するものであり,一回の検査のみで決して正確にその患者の動態を表わしているとはいいがたい.この点コンピューターを用いたRI angio-cardiography(以下RCGと略す)は被曝線量も少く,生理的状態を損うことなく繰返し検査を行うことが出来る非観血的方法であり,心疾患者の術前術後の変化,治療経過観察に極めて有用である.従って,僧帽弁疾患におけるRCGによる右室,左室peak to peak time C(2)/C(1)比の解折は,上述の点後於て重要な臨床情報を提供すると考えられる.今回は僧帽弁疾患を中心としてこれらの点について若干の検討を試みた. en-copyright= kn-copyright= en-aut-name=TanabeMasatada en-aut-sei=Tanabe en-aut-mei=Masatada kn-aut-name=田辺正忠 kn-aut-sei=田辺 kn-aut-mei=正忠 aut-affil-num=1 ORCID= en-aut-name=TamaiToyosato en-aut-sei=Tamai en-aut-mei=Toyosato kn-aut-name=玉井豊理 kn-aut-sei=玉井 kn-aut-mei=豊理 aut-affil-num=2 ORCID= en-aut-name=KawaseEtsuo en-aut-sei=Kawase en-aut-mei=Etsuo kn-aut-name=川瀬悦郎 kn-aut-sei=川瀬 kn-aut-mei=悦郎 aut-affil-num=3 ORCID= en-aut-name=TakakiHisao en-aut-sei=Takaki en-aut-mei=Hisao kn-aut-name=高木寿生 kn-aut-sei=高木 kn-aut-mei=寿生 aut-affil-num=4 ORCID= en-aut-name=MizukawaKiichiro en-aut-sei=Mizukawa en-aut-mei=Kiichiro kn-aut-name=水川帰一郎 kn-aut-sei=水川 kn-aut-mei=帰一郎 aut-affil-num=5 ORCID= en-aut-name=MorimotoSetsuo en-aut-sei=Morimoto en-aut-mei=Setsuo kn-aut-name=森本節夫 kn-aut-sei=森本 kn-aut-mei=節夫 aut-affil-num=6 ORCID= en-aut-name=HashimotoKeiji en-aut-sei=Hashimoto en-aut-mei=Keiji kn-aut-name=橋本啓二 kn-aut-sei=橋本 kn-aut-mei=啓二 aut-affil-num=7 ORCID= en-aut-name=SatoKatashi en-aut-sei=Sato en-aut-mei=Katashi kn-aut-name=佐藤功 kn-aut-sei=佐藤 kn-aut-mei=功 aut-affil-num=8 ORCID= en-aut-name=AonoKaname en-aut-sei=Aono en-aut-mei=Kaname kn-aut-name=青野要 kn-aut-sei=青野 kn-aut-mei=要 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=90 cd-vols= no-issue=7-8 article-no= start-page=993 end-page=998 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=197808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagnosis of heart disease using by RI angiocardiography Part I. Normal subjects kn-title=RI angio-cardiographyによる心疾患の診断 第一編 正常例の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study is to show applicability of RCG and to determine criteria for its use of normals. Instrumentation for data processing was DAP 500-2(Toshiba, Ltd, Tokyo Japan) RI dilution curves recorded an the right ventricle, the left lung, the left ventricle of 12 normal subjects were analyzed to obtain following parameters, namely interventricular peak to peak time and C(2)/C(1) ratio. 1) intraventricular peak to peak time average: 6.40 ± 1.18 seconds (4.80~8.64) 2) C(2)/C(1) ratio of right ventricle average: 0.45 ± 0.08 seconds (0.30~0.59) 3) C(2)/C(1) ratio of left ventricle average: 0.38 ± 0.09 seconds (0.22 ± 0.51) 4) C(2)/C(1) ratio of left lung average: 0.45 ± 0.08 seconds (0.30~0.55) en-copyright= kn-copyright= en-aut-name=TanabeMasatada en-aut-sei=Tanabe en-aut-mei=Masatada kn-aut-name=田辺正忠 kn-aut-sei=田辺 kn-aut-mei=正忠 aut-affil-num=1 ORCID= en-aut-name=TamaiToyosato en-aut-sei=Tamai en-aut-mei=Toyosato kn-aut-name=玉井豊理 kn-aut-sei=玉井 kn-aut-mei=豊理 aut-affil-num=2 ORCID= en-aut-name=KawaseEtsuo en-aut-sei=Kawase en-aut-mei=Etsuo kn-aut-name=川瀬悦郎 kn-aut-sei=川瀬 kn-aut-mei=悦郎 aut-affil-num=3 ORCID= en-aut-name=TakakiHisao en-aut-sei=Takaki en-aut-mei=Hisao kn-aut-name=高木寿生 kn-aut-sei=高木 kn-aut-mei=寿生 aut-affil-num=4 ORCID= en-aut-name=MizukawaKiichiro en-aut-sei=Mizukawa en-aut-mei=Kiichiro kn-aut-name=水川帰一郎 kn-aut-sei=水川 kn-aut-mei=帰一郎 aut-affil-num=5 ORCID= en-aut-name=MorimotoSetsuo en-aut-sei=Morimoto en-aut-mei=Setsuo kn-aut-name=森本節夫 kn-aut-sei=森本 kn-aut-mei=節夫 aut-affil-num=6 ORCID= en-aut-name=HashimotoKeiji en-aut-sei=Hashimoto en-aut-mei=Keiji kn-aut-name=橋本啓二 kn-aut-sei=橋本 kn-aut-mei=啓二 aut-affil-num=7 ORCID= en-aut-name=SatoKatashi en-aut-sei=Sato en-aut-mei=Katashi kn-aut-name=佐藤功 kn-aut-sei=佐藤 kn-aut-mei=功 aut-affil-num=8 ORCID= en-aut-name=AonoKaname en-aut-sei=Aono en-aut-mei=Kaname kn-aut-name=青野要 kn-aut-sei=青野 kn-aut-mei=要 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=知能システムを使用した化学バッチ・プラントの故障診断に関する研究 kn-title=Study of Fault Diagnosis in Chemical Batch Plant using Intelligent System en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ArdiSyahril kn-aut-sei=Ardi kn-aut-mei=Syahril aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=121 cd-vols= no-issue=3 article-no= start-page=199 end-page=203 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20091201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagnosis and primary treatment of acute pancreatitis kn-title=急性膵炎の診断と初期治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OgawaTsuneyoshi en-aut-sei=Ogawa en-aut-mei=Tsuneyoshi kn-aut-name=小川恒由 kn-aut-sei=小川 kn-aut-mei=恒由 aut-affil-num=1 ORCID= en-aut-name=KawamotoHirofumi en-aut-sei=Kawamoto en-aut-mei=Hirofumi kn-aut-name=河本博文 kn-aut-sei=河本 kn-aut-mei=博文 aut-affil-num=2 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name=山本和秀 kn-aut-sei=山本 kn-aut-mei=和秀 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=広島市立広島市民病院　内科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 END start-ver=1.4 cd-journal=joma no-vol=121 cd-vols= no-issue=3 article-no= start-page=195 end-page=198 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20091201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=JPN (Japan Pancreas Society) guidelines for the management of pancreatic cancer kn-title=膵癌診療ガイドライン―内科治療の総論について― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HiraoKen en-aut-sei=Hirao en-aut-mei=Ken kn-aut-name=平尾謙 kn-aut-sei=平尾 kn-aut-mei=謙 aut-affil-num=1 ORCID= en-aut-name=KawamotoHirofumi en-aut-sei=Kawamoto en-aut-mei=Hirofumi kn-aut-name=河本博文 kn-aut-sei=河本 kn-aut-mei=博文 aut-affil-num=2 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name=山本和秀 kn-aut-sei=山本 kn-aut-mei=和秀 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=7-8 article-no= start-page=895 end-page=902 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=19770830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Prenatal diagnosis of chromosome abnormalities with cultivated amniotic fluid cells kn-title=羊水細胞培養による染色体異常の出生前診断 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The methods for cultivation of amniotic fluid cells were described. Transabdominal amniocenteses were performed for prenatal diagnosis of chromosome abnormalities. Successful cultures for karyotyping were accomplished in 12 of 13 samples obtained from 12 patients. In one case karyotypic analysis of cultivated amniotic fluid cells revealed a karyotype of 45, X and then therapeutic abortion was performed. The karyotype of cultivated fetal skin and umbilical cord blood cells was 45, X/45, XX mosaicism. The necropsy of the aborted fetus disclosed pure gonadal dysgenesis. Prenatal genetic diagnosis with cultivated amniotic fluid cells is useful for monitoring of high-risk pregnancies. en-copyright= kn-copyright= en-aut-name=AkagiTadaatsu en-aut-sei=Akagi en-aut-mei=Tadaatsu kn-aut-name=赤木忠厚 kn-aut-sei=赤木 kn-aut-mei=忠厚 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=高知県立中央病院・癌研究所 END start-ver=1.4 cd-journal=joma no-vol=92 cd-vols= no-issue=3-4 article-no= start-page=387 end-page=392 dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=19800430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Candidiasis attributable to gastric ulcer kn-title=胃潰瘍に随伴せるCandida症に就いて en-subtitle= kn-subtitle= en-abstract=Candidiasis induced by antibiotics or steroid substances has often been reported. However, we found candidiasis in woman of 47 years which followed gastric ulcer without administration of such substances. This is extremely rare in Japan. kn-abstract=Candida症は真菌の一種のカンジダ属,特にCandida albicansによって起される疾病であり,本来は正常な皮膚,粘膜,糞便,喀痰,尿などに常在して人体に害を及ぼさない.近年各種の抗生物質,ステロイド製剤の開発に伴って,適応疾患に此等が容易に投与されており,此等薬剤の使用による副作用として色々な現象が現われて来ているが,そのうちの重要なる疾患の一つにCandida症が挙げられる.此のCandida症は上記薬剤の投与に依るのみならず,他疾患に基づく抵抗性の低下した患者においても認められることは周知の如くであり,例えば,白血病,再生不良性貧血,糖尿病等の患者,化学療法を受けた悪性腫瘍患者にも好発し易い.此等の場合多くは食道Candida症として見られることが多いが,今回我々の遭遇した患者は上記薬剤の投与もなく,心窩部痛を主訴として来院したものであり,食道,胃等の上部消化管X線検査によって,胃体中部小彎側に潰瘍像が認められ,潰瘍周辺部の粘膜像も不整を示しており一応悪性化が考えられた症例である.症例.患者は47才,主婦.主訴:約2週間前よりの心窩部痛.家族歴:特記すべきものなし.既往歴:生来健康であり薬剤常用等の経験はない.現病歴約2週間前より心窩部痛を来たし,その疼痛は心窩部をつまみ挙げる様であり特に空腹時に強く感じられ,時には夜中にも疼痛を来たすことがあった. 臨床検査 RBC,508×10(4),WBC,9200.分画像に異常なし.Hgb.16.0g/dl,MCV 98.0,GOT 26u,GPT 16u.尿一般検査では特に著変を認めない. 上部消化管X線検査 食道造影検査にては造影剤の通過は正常で狭窄等の異常所見なく,又粘膜レリーフ像にも著変は認められなかった.(Fig 1. A,B)胃造影検査では充満像では胃角部の短縮及び胃角上部小彎の不整が認められた.(Fig 2. C)圧迫撮影では小彎側中央部よりや,上方に潰瘍ニッシエがあり(Fig 2. D)潰瘍周辺は不整にして,通常みられる良性胃潰瘍よりもwallの巾が広く,又粘膜像においても潰瘍周辺部の顆粒状隆起,レリーフの不整が見られ,良性潰瘍像と少し異ったレ線像を呈しているので潰瘍癌の疑を持ち胃生検を行なうことにした. 胃内視鏡所見 胃体中部小彎側に大きな潰瘍による陥凹部を認め,その辺縁は平滑であったが,潰瘍部の周辺は隆起し潰瘍表面は不整で出血を認めた.そこで潰瘍部のうち3ヶ所をえらんで組織生検を行った. 生検組織所見 岡山大学医学部病理学教室に依頼した病理診断所見によれば,「Gastric ulcer with candidiasis and repairing mucosa, no malignancy｣ であり,間質にはround cell infiltrationがある. bleedingを伴っており,ulcer floorにはfungusが増殖している.再生上皮,異型性は余りない. (Fig.4, E.F.G.H) 以上の結果によりCandidaが増殖している場合には,組織学的に悪性度は認め難い場合でもcancerを完全に否定し得ないこともあり手術に踏切った. 摘出標本組織診断 「Gastric ulcer (Ul-Ⅳ) and chronic active gastritis, no malignancy.」ulcer floorはnecrotic massとgranulationが著明で此のgranulation changeはadipose tissueに及んでいる(Ul-Ⅳ).mucosaは比較的異型性は軽度でmalignancyの所見は認められず,間質はround cellのnodular infiltrationが著明に見られた.以上の如く生検並に手術摘出標本の組織所見によって胃レ線所見において悪性像の如く考えられたのは胃潰瘍に併存したCandidiasisの為によって,斯くの如きレ線像を呈したものと思われる.術后経過における種々の臨床検査成績に著変なく患者は順調である. en-copyright= kn-copyright= en-aut-name=YamamotoMichio en-aut-sei=Yamamoto en-aut-mei=Michio kn-aut-name=山本道夫 kn-aut-sei=山本 kn-aut-mei=道夫 aut-affil-num=1 ORCID= en-aut-name=KimotoShin en-aut-sei=Kimoto en-aut-mei=Shin kn-aut-name=木本真 kn-aut-sei=木本 kn-aut-mei=真 aut-affil-num=2 ORCID= en-aut-name=IguchiYoshiko en-aut-sei=Iguchi en-aut-mei=Yoshiko kn-aut-name=井口与志子 kn-aut-sei=井口 kn-aut-mei=与志子 aut-affil-num=3 ORCID= en-aut-name=AkagiKeiko en-aut-sei=Akagi en-aut-mei=Keiko kn-aut-name=赤木螢子 kn-aut-sei=赤木 kn-aut-mei=螢子 aut-affil-num=4 ORCID= en-aut-name=HirakiYoshio en-aut-sei=Hiraki en-aut-mei=Yoshio kn-aut-name=平木祥夫 kn-aut-sei=平木 kn-aut-mei=祥夫 aut-affil-num=5 ORCID= en-aut-name=AonoKaname en-aut-sei=Aono en-aut-mei=Kaname kn-aut-name=青野要 kn-aut-sei=青野 kn-aut-mei=要 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部放射線医学教室 en-keyword=胃 cadida 症 kn-keyword=胃 cadida 症 en-keyword=X 線診断 kn-keyword=X 線診断 END start-ver=1.4 cd-journal=joma no-vol=91 cd-vols= no-issue=5-6 article-no= start-page=585 end-page=609 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=19790630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical study on diagnosis of the site and level of nerve lesions by somatosensory cerebral evoked responses kn-title=体知覚性大脳誘発電位による神経病変の局在と高位診断に関する臨床的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The present study investigated the possibility of clinical application of somatosensory cerebral evoked response (SER) in the diagnosis of the site and level of various neural lesions (peripheral and central). SERs were recorded from the hand-sensory area of the scalp by electrical stimulation of the median nerve at the wrist and an averaging procedure (digital computer). The study group comprised 43 healthy subjects and 267 patients clinically having the following neural lesions: peripheral nerve lesion (50 patients); cervical nerve root lesion (17); spinal cord lesion (52); brain stem/cerebellum lesion(33); internal capsule/thalamus/basal ganglia lesion (53); frontal cortex lesion (14); frontopariental cortex lesion(33); or parieto-temporal cortex lesion(25). Abnormal SER wave patterns were classified into 11 types by comparison with both normal SER patterns obtained from the healthy subjects and the clinical diagnoses. The results were as follows: 1. Normal SER waves always consisted of a pattern of 5 peaks (3 negative and 2 positive: N1, P1, N2, P2, N3). 2. Abnormal SER wave patterns were classified into 11 types (author's classification): "Type A", prolonged latency of N1; "Type B", low amplitude of all peaks; "Type C", flat pattern without peaks; "Type Da", lack of N1; "Type Db", N1 present but other waves absent; "Type Dc", N2 absent; "Type Dd", high amplitude of N2; "Type De", high amplitude of N3; "Type Df", high amplitude of N1; "Type Ea", unilateral high amplitude of all peaks; and "Type Eb", high amplitude of all peaks bilaterally. 3. In peripheral nerve, cervical nerve root or spinal cord lesions, SERs were usually Type A, B, or C and reflected the degree of sensory impairment. SERs showed little variation in patients having motor nerve impairment only. In internal capsule/thalamus/basal ganglia lesions, SERs were usually Type B or C. In contrast to the results for peripheral nerve lesions, this was true not only in patients with sensory impairments but also in those who had motor impairment only. Type De was detected in some patients with motor impairment only. Such variations in the SER pattern seemed to be derived from the site and grade of lesion. In cortex lesions, SER often showed Type Dc, De, or Ea unrelated to whether the impairment was sensory or motor in nature. Type Dc was characteristic of lesions associated with the motor cortex, implying that this area was the origin of the N2 peak. 4. Abnormal SERs were detected in 58.8% of all the 267 patients. 46.9% of patients with motor impairment only and 77.5% of patients with more than moderate sensory impairment had abnormal SERs. 5. The origins of the components of the SER pattern were thought to be as follows: N1 and P1, direct primary response to the stimulus via the specific sensory projection system; N2 and P2, association areas near the sensory-motor cortex; the late component N3, non-specific sensory projection system. These results for SERs suggest that clinical application of the SER may prove extremely useful in diagnosing the site and level of neural lesions. en-copyright= kn-copyright= en-aut-name=SuemaruKoso en-aut-sei=Suemaru en-aut-mei=Koso kn-aut-name=末丸紘三 kn-aut-sei=末丸 kn-aut-mei=紘三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 en-keyword=体知覚性大脳誘発電位 kn-keyword=体知覚性大脳誘発電位 en-keyword=異常波形分類 kn-keyword=異常波形分類 en-keyword=神経病変 kn-keyword=神経病変 en-keyword=局在と高位診断 kn-keyword=局在と高位診断 en-keyword=構成成分の生成機序 kn-keyword=構成成分の生成機序 END start-ver=1.4 cd-journal=joma no-vol=91 cd-vols= no-issue=3-4 article-no= start-page=525 end-page=531 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=19790430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of pulmonary bronchogenic cyst complicated by pulmonary tuberculosis kn-title=診断困難であった肺結核と気管支性肺嚢胞の合併症例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 53 year old male was admitted to the Okayama University Medical School Hospital in June 1975 with a history of chronic cough and sputum. The patient had previously undergone treatment for pulmonary tuberculosis for 18 months at another hospital. Roentgenologic examination showed a lobulated mass and fibrotic density in the left upper lung field. Left upper lobectomy was performed. The histopathologic diagnosis was pulmonary bronchogenic cyst with pulmonary tuberculosis in the same segment. In this report, the roentgenological findings and differential diagnosis of pulmonary bronchogenic cyst are described. en-copyright= kn-copyright= en-aut-name=MorinoYasuo en-aut-sei=Morino en-aut-mei=Yasuo kn-aut-name=森野靖雄 kn-aut-sei=森野 kn-aut-mei=靖雄 aut-affil-num=1 ORCID= en-aut-name=KimotoShin en-aut-sei=Kimoto en-aut-mei=Shin kn-aut-name=木本真 kn-aut-sei=木本 kn-aut-mei=真 aut-affil-num=2 ORCID= en-aut-name=SatoKatashi en-aut-sei=Sato en-aut-mei=Katashi kn-aut-name=佐藤功 kn-aut-sei=佐藤 kn-aut-mei=功 aut-affil-num=3 ORCID= en-aut-name=HashimotoKeiji en-aut-sei=Hashimoto en-aut-mei=Keiji kn-aut-name=橋本啓二 kn-aut-sei=橋本 kn-aut-mei=啓二 aut-affil-num=4 ORCID= en-aut-name=MizukawaKiichiro en-aut-sei=Mizukawa en-aut-mei=Kiichiro kn-aut-name=水川帰一郎 kn-aut-sei=水川 kn-aut-mei=帰一郎 aut-affil-num=5 ORCID= en-aut-name=MorimotoSetsuo en-aut-sei=Morimoto en-aut-mei=Setsuo kn-aut-name=森本節夫 kn-aut-sei=森本 kn-aut-mei=節夫 aut-affil-num=6 ORCID= en-aut-name=TamaiToyosato en-aut-sei=Tamai en-aut-mei=Toyosato kn-aut-name=玉井豊理 kn-aut-sei=玉井 kn-aut-mei=豊理 aut-affil-num=7 ORCID= en-aut-name=AonoKaname en-aut-sei=Aono en-aut-mei=Kaname kn-aut-name=青野要 kn-aut-sei=青野 kn-aut-mei=要 aut-affil-num=8 ORCID= en-aut-name=TanabeMasatada en-aut-sei=Tanabe en-aut-mei=Masatada kn-aut-name=田辺正忠 kn-aut-sei=田辺 kn-aut-mei=正忠 aut-affil-num=9 ORCID= en-aut-name=ItagakiFumio en-aut-sei=Itagaki en-aut-mei=Fumio kn-aut-name=板垣文夫 kn-aut-sei=板垣 kn-aut-mei=文夫 aut-affil-num=10 ORCID= en-aut-name=SimizuNobuyoshi en-aut-sei=Simizu en-aut-mei=Nobuyoshi kn-aut-name=清水信義 kn-aut-sei=清水 kn-aut-mei=信義 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線科 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線科 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線科 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線科 affil-num=5 en-affil= kn-affil=岡山大学医学部放射線科 affil-num=6 en-affil= kn-affil=岡山大学医学部放射線科 affil-num=7 en-affil= kn-affil=岡山大学医学部放射線科 affil-num=8 en-affil= kn-affil=岡山大学医学部放射線科 affil-num=9 en-affil= kn-affil=岡山大学医学部放射線科 affil-num=10 en-affil= kn-affil=岡山大学医学部第II外科 affil-num=11 en-affil= kn-affil=岡山大学医学部第II外科 en-keyword=Bronchogenic cyst kn-keyword=Bronchogenic cyst en-keyword=Pulmonary tuberculosis kn-keyword=Pulmonary tuberculosis END start-ver=1.4 cd-journal=joma no-vol=94 cd-vols= no-issue=7-8 article-no= start-page=683 end-page=692 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the diagnosis and treatment of human lung cancer using double-layered soft agar cloning assay Ⅱ. Direct cloning of human lung cancer cells and in vitro chemosensitivity test kn-title=コロニー形成法を利用したヒト肺癌の診断と治療に関する研究 第2編 ヒト肺癌細胞のdirect cloning及びin vitro制癌剤感受性試験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The extent of tumor dissemination at the time of diagnosis is an important predictor for survival of lung cancer patients. In vitro sensitivity to drugs is helpful for successful chemotherapy of advanced lung cancer patients. A major objective of the present study was to clarify the significance of direct cloning assay for the detection of metastatic sites as well as for the selection of sensitive drugs for individual patients. Tumor cell colony growth was evaluated in an enriched double-layered soft agar system. Colonies were successfully grown from 5 of 7 cytology positive effusions, and 4 of 5 histology/cytology positive bone marrow aspirates. Two of 17 histology/cytology negative bone marrow aspirates yielded colonies, whereas 5 cytology negative effusions yielded no colonies. Colony growth was observed in 3 of 5 tumor specimens obtained surgically. For in vitro chemosensitivity, tumor cells were exposed for 1 hour prior to plating. Although colonies were successfully grown from specimens of 5 patients, none of them were sensitive to the drugs tested. Three of the 5 patients were treated with intensive combination chemotherapy including therapy with drugs which had been defined to be resistant in the in vitro chemosensitivity test and no response was observed in these cases. In this sense, in vitro sensitivity correlated with in vivo sensitivity. en-copyright= kn-copyright= en-aut-name=MiyaiMasahiro en-aut-sei=Miyai en-aut-mei=Masahiro kn-aut-name=宮井正博 kn-aut-sei=宮井 kn-aut-mei=正博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第2内科学教室 en-keyword=tumor stem cell assay in man kn-keyword=tumor stem cell assay in man en-keyword=lung cencer kn-keyword=lung cencer en-keyword=in vitro chemosensitivity test kn-keyword=in vitro chemosensitivity test END start-ver=1.4 cd-journal=joma no-vol=94 cd-vols= no-issue=7-8 article-no= start-page=673 end-page=681 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the diagnosis and treatment of human lung cancer using double-layered soft agar cloning assay I. In vitro chemosensitivity test on permanent cell lines from adeno-, epidermoid and small cell carcinoma of the lung using double-layered soft agar cloning assay kn-title=コロニー形成法を利用したヒト肺癌の診断ならびに治療に関する研究 第1編 ヒト肺癌細胞株(腺癌,扁平上皮癌,小細胞癌)のin vitro制癌剤感受性試験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=An in vitro chemosensitivity test on permanent cell lines from adeno-, epidermoid and small cell carcinoma of the lung was performed using a double-layered soft agar cloning assay. Drugs tested in the present study were Adriamycin, 40497S, Mitomycin C, cis-Dichlorodiammineplatinum, Methotrexate and Vincristine. Adriamycin, 40497S, Mitomycin C and cis-Dichlorodiammineplatinum showed dose-dependent cytotoxity. Methotrexate and Vincristine did not show a significant cytotoxity when the cell lines were exposed for one hour. Differences in chemosensitivity to the six drugs examined among the three cell lines was relatively small e.g. the lethal dose 90% (LD90) of Adriamycin was 0.19mcg/ml in adenocarcinoma, 0.46mcg/ml in epidermoid carcinoma and 0.27mcg/ml in small cell carcinoma. The lack of a difference in chemosensitivity in vitro might be attributed to the fact that the cell lines had been established from bronchogenic carcinomas which were refractory to intensive combination chemotherapy. en-copyright= kn-copyright= en-aut-name=MiyaiMasahiro en-aut-sei=Miyai en-aut-mei=Masahiro kn-aut-name=宮井正博 kn-aut-sei=宮井 kn-aut-mei=正博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第2内科学教室 en-keyword=human lung cancer cell lines kn-keyword=human lung cancer cell lines en-keyword=in vitro chemosensitivity test kn-keyword=in vitro chemosensitivity test en-keyword=cloning assay kn-keyword=cloning assay END