鉄の吸収に関する実験的研究 第一編 胃に於ける鉄の吸收過程に関する研究

It is generally believed that the main part of the physiologic absorption of iron is the upper part of the duodenum. But iron can actually be absorbed from the stomach. Isolating the rabbit stomach from the oesophagus and duodenum by ligating cardia and pyrolus, the author observed the process of iron absorption from the mucosa of the stomach. After the ligation of pyrolus and cardia the contents of stomach were removed giving a small cut at the great curvature and then suturing the cut after inserting a drain-syphon with a stopper at the exterior end. Next, 50-60 cc. of FeC1(3) solution, 20 to 100 mg iron per dl. was introduced from the drain-syphon, and the iron level of the contents of the stomach and blood serum were estimated colorimetrically at fixed intervals. After the introduction of iron the elevated iron level in stomach fell quickly and after 2 to 3 hours it reached the minimum, about 60 per cent of the initial level, at which the absorption stopped. In contrast to this, the serum iron level increased gradually reaching the maximum, 230-300 γ, at about 3 hours after the introduction of iron, keeping this level thereafter. No marked difference in absorption was found between ferric and ferrous iron. From these observations the author concluded that the stomach has an active ability to absorb iron, which is sufficient enough to elevate the serum iron level without the aid of the duodenum.