| ID | 40642 |
| フルテキストURL | |
| タイトル（別表記） | Studies on the role of eosinophils in the pathogenesis of bronchial asthma Part 1. Evaluation of serum eosinophil chemotactic factor in asthmatic responses using eosinophils purified by flow cytometry
|
| 著者 |
河田 一郎
岡山大学医学部第二内科学教室
|
| 抄録 | The serum eosinophil chemotactic factor (ECF) was evaluated by use of the modified Boyden chamber method. Flow cytometry (FCM) was applied to obtain highly purified eosinophils from peripheral blood of normal subjects. The maximal chemotaxis of these eosinophils was shown at 1×10(-7) M of platelet activating factor and leukotriene B4. In bronchial asthmatics with immediate asthmatic response (IAR), serum ECF activity showed only an early rise, and that in asthmatics with late asthmatic response (LAR) showed a precedent rise before bronchial reaction. Asthmatic patients with both IAR and LAR showed biphasic elevation in ECF activity. These findings suggest that the function of ECF in the pathogenesis of IAR is different from that in LAR. The eosinophils purified by FCM were very useful for measurement of ECF by the Boyden chamber method.
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| キーワード | Bronchial asthma
Eosinophil
Eosinophil chemotactic factor (ECF)
Flow cytometry
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| 発行日 | 1990-06
|
| 出版物タイトル |
岡山医学会雑誌
|
| 出版物タイトル（別表記） | Journal of Okayama Medical Association
|
| 巻 | 102巻
|
| 号 | 5-6号
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| 出版者 | 岡山医学会
|
| 出版者（別表記） | Okayama Medical Association
|
| 開始ページ | 733
|
| 終了ページ | 743
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| ISSN | 0030-1558
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| NCID | AN00032489
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| 資料タイプ |
学術雑誌論文
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| オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/102/5-6/102_5-6_733/_article/-char/ja/
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| 関連URL | http://www.okayama-u.ac.jp/user/oma/
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| 言語 |
日本語
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| 著作権者 | 岡山医学会
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| 論文のバージョン | publisher
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| 査読 |
有り
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| Eprints Journal Name | joma
|
