On the Histological Changes of the Cardiac Muscle caused by the Experimental Uremia, a Comparative Study with those in Consequence of an Oedema or Urea-injection.

<P>1. The cardiac muscle fibres of the rabbit swell more and more in the course of the artificial uremia. In the early stage of the disease, this swelling is almost confined to the sarcoplasm, but later the fibrils take part in it also. In the latter stage of the disease, the swelling of both of these two becomes considerable, so that the muscle assumes a characterized feature. 2. The cardiac muscle fibres of the rabbit made artificially oedematous show a swelling also, but in this case the sarcoplasm takes only a little part in it. 3. The cardiac muscle of the rabbit submitted to the urea-injection bears a close resemblance to the finding seen in the case of the artificial uremia. 4. The histological changes of the cardiac muscle caused by the uremia are chiefly due to the urea or its analytic substance retained in the blood, the oedematous stagnation of water having little concern in it. In closing this paper, I wish to express my best thanks to Dr. K. Kosaki under whose guidance this work has been performed.</P>