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著者 Sukegawa, Shintaro| Yoshii, Kazumasa| Hara, Takeshi| Tanaka, Futa| Yamashita, Katsusuke| Kagaya, Tutaro| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Nagatsuka, Hitoshi| Furuki, Yoshihiko|
発行日 2022-07-27
出版物タイトル Plos One
17巻
7号
出版者 Public Library Science
開始ページ e0269016
ISSN 1932-6203
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 Sukegawa et al.
論文のバージョン publisher
PubMed ID 35895591
DOI 10.1371/journal.pone.0269016
Web of Science KeyUT 000880183400018
関連URL isVersionOf https://doi.org/10.1371/journal.pone.0269016
フルテキストURL fulltext.pdf
著者 Nakata, Kentaro| Okazaki, Mikio| Sakaue, Tomohisa| Kinoshita, Rie| Komoda, Yuhei| Shimizu, Dai| Yamamoto, Haruchika| Tanaka, Shin| Suzawa, Ken| Shien, Kazuhiko| Miyoshi, Kentaroh| Yamamoto, Hiromasa| Ohara, Toshiaki| Sugimoto, Seiichiro| Yamane, Masaomi| Matsukawa, Akihiro| Sakaguchi, Masakiyo| Toyooka, Shinichi|
キーワード ischemia reperfusion injury S100A8/A9 lung transplantation damage-associated molecule patterns
発行日 2022-11-10
出版物タイトル Bioengineering
9巻
11号
出版者 MDPI
開始ページ 673
ISSN 2306-5354
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 by the authors.
論文のバージョン publisher
PubMed ID 36354584
DOI 10.3390/bioengineering9110673
Web of Science KeyUT 000880897200001
関連URL isVersionOf https://doi.org/10.3390/bioengineering9110673
フルテキストURL fulltext.pdf
著者 Maruo, Yukinori| Yoshihara, Kumiko| Irie, Masao| Nagaoka, Noriyuki| Matsumoto, Takuya| Minagi, Shogo|
キーワード acrylate methacrylate CAD/CAM flexural strength shear bond strength
発行日 2022-10-28
出版物タイトル Materials
15巻
21号
出版者 MDPI
開始ページ 7564
ISSN 1996-1944
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 by the authors.
論文のバージョン publisher
PubMed ID 36363156
DOI 10.3390/ma15217564
Web of Science KeyUT 000881219600001
関連URL isVersionOf https://doi.org/10.3390/ma15217564
フルテキストURL fulltext.pdf
著者 Oo, May Wathone| Kawai, Hotaka| Eain, Htoo Shwe| Soe, Yamin| Takabatake, Kiyofumi| Sanou, Sho| Shan, Qiusheng| Inada, Yasunori| Fujii, Masae| Fukuhara, Yoko| Wang, Ziyi| Sukegawa, Shintaro| Ono, Mitsuaki| Nakano, Keisuke| Nagatsuka, Hitoshi|
キーワード oral squamous cell carcinoma tumor microenvironment tumor stroma tumor vascularization extracellular superoxide dismutase (SOD3) vascular endothelial cadherin (Ve-cadherin)
発行日 2022-10-28
出版物タイトル Biomedicines
10巻
11号
出版者 MDPI
開始ページ 2729
ISSN 2227-9059
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 by the authors.
論文のバージョン publisher
PubMed ID 36359248
DOI 10.3390/biomedicines10112729
Web of Science KeyUT 000881045700001
関連URL isVersionOf https://doi.org/10.3390/biomedicines10112729
フルテキストURL fulltext.pdf
著者 Werner, Rudolf A.| Higuchi, Takahiro| Nose, Naoko| Toriumi, Fujio| Matsusaka, Yohji| Kuji, Ichiei| Kazuhiro, Koshino|
発行日 2022-11-05
出版物タイトル Scientific Reports
12巻
1号
出版者 Nature Portfolio
開始ページ 18787
ISSN 2045-2322
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2022
論文のバージョン publisher
PubMed ID 36335166
DOI 10.1038/s41598-022-23325-3
Web of Science KeyUT 000879722100016
関連URL isVersionOf https://doi.org/10.1038/s41598-022-23325-3
フルテキストURL fulltext.pdf
著者 Yokogi, Kyoka| Goto, Yuki| Otsuka, Mai| Ojima, Fumiya| Kobayashi, Tomoe| Tsuchiba, Yukina| Takeuchi, Yu| Namba, Masumi| Kohno, Mayumi| Tetsuka, Minami| Takeuchi, Sakae| Matsuyama, Makoto| Aizawa, Sayaka|
発行日 2022-10-27
出版物タイトル Scientific Reports
12巻
1号
出版者 Nature Portfolio
開始ページ 17472
ISSN 2045-2322
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2022
論文のバージョン publisher
PubMed ID 36302800
DOI 10.1038/s41598-022-21764-6
Web of Science KeyUT 000876924900034
関連URL isVersionOf https://doi.org/10.1038/s41598-022-21764-6
フルテキストURL fulltext20221117-1.pdf
著者 Katayama, Yukitoshi| Miura, Ayane| Sakamoto, Tatsuya| Takanami, Keiko| Sakamoto, Hirotaka|
キーワード itchy eyes histamine gastrin-releasing peptide receptor footedness
発行日 2022-10-19
出版物タイトル Proceedings of the Royal Society B: Biological Sciences
289巻
1985号
出版者 The Royal Society
開始ページ 20221126
ISSN 0962-8452
NCID AA00786976
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 The Author(s)
論文のバージョン author
PubMed ID 36259204
DOI 10.1098/rspb.2022.1126
Web of Science KeyUT 000872392900003
関連URL isVersionOf https://doi.org/10.1098/rspb.2022.1126
フルテキストURL fulltext20221116-2.pdf
著者 Gotoh, Kazuyoshi| Hagiya, Hideharu| Iio, Koji| Yamada, Haruto| Matsushita, Osamu| Otsuka, Fumio|
キーワード Antimicrobial resistance Carbapenemase-producing Enterobacterales Carbapenem-resistant Enterobacterales New Delhi metallo-β-lactamase (NDM) Enterobacter cloacae complex
備考 © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.08.019] .| This full-text will be available in Oct. 2023.|
発行日 2022-12
出版物タイトル Journal of Infection and Chemotherapy
28巻
12号
出版者 Elsevier BV
開始ページ 1697
終了ページ 1699
ISSN 1341-321X
NCID AA11057978
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
論文のバージョン author
PubMed ID 36049614
DOI 10.1016/j.jiac.2022.08.019
Web of Science KeyUT 000874559900019
関連URL isVersionOf https://doi.org/10.1016/j.jiac.2022.08.019
フルテキストURL fulltext20221116-1.pdf
著者 Takahashi, Misa| Hagiya, Hideharu| Koyama, Toshihiro| Otsuka, Fumio|
キーワード aging sexual health sexually transmitted infection spirochete syphilis
備考 This is the peer reviewed version of the following article: [Takahashi, M, Hagiya, H, Koyama, T, Otsuka, F. Trends in the incidence of syphilis in the middle-aged and older adults in Japan: A nationwide observational study, 2009–2019. Geriatr. Gerontol. Int. 2022; 22: 1019–1024. https://doi.org/10.1111/ggi.14500], which has been published in final form at [https://doi.org/10.1111/ggi.14500]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This full-text will be available in Nov. 2023.|
発行日 2022-11-01
出版物タイトル Geriatrics and Gerontology International
22巻
12号
出版者 Wiley
開始ページ 1019
終了ページ 1024
ISSN 1444-1586
NCID AA1155729X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 Japan Geriatrics Society.
論文のバージョン author
PubMed ID 36320169
DOI 10.1111/ggi.14500
Web of Science KeyUT 000877369900001
関連URL isVersionOf https://doi.org/10.1111/ggi.14500
フルテキストURL fulltext.pdf
著者 Tsuge, Mitsuru| Kodera, Aya| Sumitomo, Hiromi| Araki, Tooru| Yoshida, Ryuichi| Yasui, Kazuya| Sato, Hiroki| Washio, Yosuke| Washio, Kana| Shigehara, Kenji| Yashiro, Masato| Yagi, Takahito| Tsukahara, Hirokazu|
キーワード Neonatal hemochromatosis Thalassemia Liver transplantation Gestational alloimmune liver disease Case report Hepcidin Ineffective erythropoiesis Growth differentiation factor-15
発行日 2022-10-29
出版物タイトル BMC Pediatrics
22巻
1号
出版者 BMC
開始ページ 622
ISSN 1471-2431
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2022.
論文のバージョン publisher
PubMed ID 36309641
DOI 10.1186/s12887-022-03706-3
Web of Science KeyUT 000876287400002
関連URL isVersionOf https://doi.org/10.1186/s12887-022-03706-3
フルテキストURL fulltext20221110-3.pdf
著者 Nakano, Yumiko| Taira, Yuki| Sasaki, Ryo| Tadokoro, Koh| Yunoki, Taijun| Nomura, Emi| Fukui, Yusuke| Takemoto, Mami| Morihara, Ryuta| Shimozawa, Nobuyuki| Yamashita, Toru|
キーワード adrenoleukodystrophy symptomatic female carriers spastic paraplegia ABCD1
備考 This is the peer reviewed version of the following article: [Nakano, Y, Taira, Y, Sasaki, R, et al. Novel ABCD1 mutation detected in a symptomatic female carrier of adrenoleukodystrophy. Neurol Clin Neurosci. 2023; 11: 58-60. doi: 10.1111/ncn3.12667], which has been published in final form at [https://doi.org/10.1111/ncn3.12667]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.|
発行日 2022-10-17
出版物タイトル Neurology and Clinical Neuroscience
11巻
1号
出版者 Wiley
開始ページ 58
終了ページ 60
ISSN 2049-4173
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd.
論文のバージョン author
DOI 10.1111/ncn3.12667
Web of Science KeyUT 000868833900001
関連URL isVersionOf https://doi.org/10.1111/ncn3.12667
フルテキストURL fulltext20221110-3.pdf
著者 Shimomae, Koichi| Sato, Takuya| Yoshida, Yuichi| Naing, Shine Shane| Miyatake, Takahisa|
キーワード Diptera Lifespan Pollination Quality control
備考 © 2022 Korean Society of Applied Entomology. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.aspen.2022.101999] .| This full-text file will be available in Oct. 2023.|
発行日 2022-12
出版物タイトル Journal of Asia-Pacific Entomology
25巻
4号
出版者 Elsevier BV
開始ページ 101999
ISSN 1226-8615
NCID AA11262547
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 Korean Society of Applied Entomology.
論文のバージョン author
DOI 10.1016/j.aspen.2022.101999
Web of Science KeyUT 000868905600009
関連URL isVersionOf https://doi.org/10.1016/j.aspen.2022.101999
フルテキストURL fulltext20221114-1.pdf
著者 Isobe, Hiroshi| Shoji, Mitsuo| Suzuki, Takayoshi| Shen, Jian-Ren| Yamaguchi, Kizashi|
備考 This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Physical Chemistry B, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jpcb.2c02596| This full-text will be available in Sep. 2023.|
発行日 2022-09-15
出版物タイトル The Journal of Physical Chemistry B
126巻
38号
出版者 American Chemical Society (ACS)
開始ページ 7212
終了ページ 7228
ISSN 1520-6106
NCID AA11114073
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 American Chemical Society
論文のバージョン author
PubMed ID 36107406
DOI 10.1021/acs.jpcb.2c02596
Web of Science KeyUT 000863255500001
関連URL isVersionOf https://doi.org/10.1021/acs.jpcb.2c02596
JaLCDOI 10.18926/AMO/64127
フルテキストURL 76_6_749.pdf
著者 Takami, Masanari| Yukawa, Yasutsugu| Noda, Yusuke| Yoshida, Munehito| Yamada, Hiroshi|
抄録 We provide the first report of successful salvage surgery for a post-C1 laminectomy symptomatic recurrence of a retro-odontoid pseudotumor (ROP) that caused myelopathy. The 72-year-old Japanese woman presented with an ROP causing symptomatic cervical myelopathy. With ultrasonography support, we performed the enucleation of the ROP via a transdural approach and fusion surgery for the recurrence of the mass. At the final observation 2-year post-surgery, MRI demonstrated the mass’s regression and spinal cord decompression, and the patient’s symptoms had improved. Our strategy is an effective option for a symptomatic recurrence of ROP.
キーワード recurrent retro-odontoid pseudotumor salvage surgery transdural resection C1 laminectomy ultra-sonography
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2022-12
76巻
6号
出版者 Okayama University Medical School
開始ページ 749
終了ページ 754
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 36549779
Web of Science KeyUT 000905195100017
JaLCDOI 10.18926/AMO/64126
フルテキストURL 76_6_743.pdf
著者 Tanaka, Masato| Suthar, Hardik| Desai, Dhvanit| Yamauchi, Taro| Arataki, Shinya| Fujiwara, Yoshihiro| Uotani, Koji| Oda, Yoshiaki| Misawa, Haruo|
抄録 We describe a floating technique via a posterolateral approach with intraoperative O-arm navigation to facilitate decompression of the spinal cord in thoracic myelopathy due to severe ossification of the posterior longitudinal ligament (OPLL). A 62-year-old man with myelopathy due to thoracic OPLL had left-leg muscle weakness, urinary disturbance, and spastic gait. Bilateral leg pain and gait disturbance had persisted for 2 years. He was successfully treated by the posterolateral OPLL floating procedure and posterior pedicle fixation under O-arm navigation. At a 2-year follow-up, manual muscle testing results and sensory function of the left leg had recovered fully. His cervical Japanese Orthopedic Association score had improved from 5/12 to 11/12. The novel intraoperative O-arm navigation-guided posterolateral floating procedure for thoracic OPLL is effective for achieving precise decompression and strong fixation with a posterior approach only and can provide an excellent result for severe thoracic OPLL without the risk of adverse events from intraoperative radiation.
キーワード ossification of the posterior longitudinal ligament floating method navigation surgery C-arm free
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2022-12
76巻
6号
出版者 Okayama University Medical School
開始ページ 743
終了ページ 748
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 36549778
Web of Science KeyUT 000905195100016
JaLCDOI 10.18926/AMO/64125
フルテキストURL 76_6_737.pdf
著者 Yamaoka, Masakazu| Yamamoto, Yumi| Minami, Eriko|
抄録 Paraplegia after an operation for acute aortic dissection Stanford type A (AADA) is fairly uncommon, and there is no consensus about optimal treatment. We present a case in which cerebrospinal fluid drainage (CSFD) and permissive hypertension were used for treatment of paraplegia. When the patient showed complete bilateral paraplegia after operation for AADA, we immediately began CSFD and maintained mean arterial blood pressure at over 90 mmHg. His neurological deficit gradually recovered, and he was eventually able to walk without support. The combination of CSFD and permissive hypertension could be a first-line emergent treatment for postoperative paraplegia after AADA surgery.
キーワード paraplegia acute aortic dissection cerebrospinal drainage permissive hypertension
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2022-12
76巻
6号
出版者 Okayama University Medical School
開始ページ 737
終了ページ 742
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 36549777
Web of Science KeyUT 000905195100015
JaLCDOI 10.18926/AMO/64124
フルテキストURL 76_6_731.pdf
著者 Kamamura, Maho| Higaki, Fumiyo| Sasada, Susumu| Matsushita, Toshi| Yasuhara, Takao| Date, Isao| Hiraki, Takao|
抄録 We report a rare case of idiopathic spinal cord herniation (ISCH) with a history of cerebrospinal fluid (CSF) leakage. ISCH is a protrusion of the spinal cord through a dural defect. Thin constructive interference in steady-state (CISS) images clearly demonstrated the herniated cord in the present case. The myelopathy worsened and the patient underwent surgery for reduction of herniated spinal cord; the dural defect was filled by placing collagen matrix graft (DuraGen®) between the inner and outer dural layers. The patient’s symptoms have improved without relapse for 8 months since surgery. This method may be a good surgical option for cases of spinal cord herniation.
キーワード cerebrospinal fluid leakage constructive interference in steady state collagen matrix graft magnetic resonance image spinal cord herniation
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2022-12
76巻
6号
出版者 Okayama University Medical School
開始ページ 731
終了ページ 736
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 36549776
Web of Science KeyUT 000905195100014
JaLCDOI 10.18926/AMO/64123
フルテキストURL 76_6_723.pdf
著者 Zhang, Quan| Yang, Lixia| Wan, Guozhen| Zhang, Xiaoqiang| Wang, Ying| Zhao, Guannan|
抄録 The diagnostic value of microRNA-377 (miR-377) in patients with acute coronary syndrome (ACS) and explored miR-377’s potential mechanisms. We performed an qRT-PCR to assess serum miR-377 levels in ACS patients and coronary artery ligation rat models. The diagnostic value of miR-377 was evaluated by determining the ROC curve. An ELISA assay was conducted to detect the model rat endothelial damage markers von Willebrand factor (vWF) and heart-type fatty acid binding protein (H-FABP), and proinflammatory cytokines TNF-α, IL-6, and IL-1β. The serum miR-377 level was elevated in the ACS patients and significantly increased in the ACS rats. MiR-377 has a high diagnostic value in ACS patients, with a 0.844 ROC, 76.47% specificity, and 87.10% sensitivity. MiR-377 was positively correlated with the expressions of vWF, H-FABP, cTnI, TNF-α, IL-6, and IL-1β. In ACS rats, reducing the expression of miR-377 significantly inhibited the increases in vWF, H-FABP, TNF-α, IL-6, and IL-1β. An elevated miR-377 level can be used as a diagnostic marker in patients with ACS. A reduction of miR-377 may alleviate ACS by improving myocardial damage such as endothelial injury and the inflammatory response.
キーワード microRNA-377 acute coronary syndrome diagnosis endothelial injury inflammatory
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-12
76巻
6号
出版者 Okayama University Medical School
開始ページ 723
終了ページ 730
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 36549775
Web of Science KeyUT 000905195100013
JaLCDOI 10.18926/AMO/64122
フルテキストURL 76_6_715.pdf
著者 Mohammed Zahedul Islam Nizami| Gorduysus, Melahat| Shinoda-Ito, Yuki| Yamamoto, Tadashi| Nishina, Yuta| Takashiba, Shogo| Arias, Zulema|
抄録 The failure of endodontic treatment is directly associated with microbial infection in the root canal or periapical areas. An endodontic sealer that is both bactericidal and biocompatible is essential for the success of root canal treatments. This is one of the vital issues yet to be solved in clinical dental practice. This in vitro study assessed the effectiveness of graphene oxide (GO) composites GO-CaF2 and GO-Ag-CaF2 as endodontic sealer materials. Dentin slices were coated with either the GO-based composites or commonly used root canal sealers (non-eugenol zinc oxide sealer). The coated slices were treated in 0.9% NaCl, phosphate-buffered saline (PBS), and simulated body fluid (SBF) at 37˚C for 24 hours to compare their sealing effect on the dentin surface. In addition, the radiopacity of these composites was examined to assess whether they complied with the requirements of a sealer for good radiographic visualization. Scanning electron microscopy showed the significant sealing capability of the composites as coating materials. Radiographic images confirmed their radiopacity. Mineral deposition indicated their bioactivity, especially of GO-Ag-CaF2, and thus it is potential for regenerative application. They were both previously shown to be bactericidal to oral microbes and cytocompatible with host cells. With such a unique assemblage of critical properties, these GO-based composites show promise as endodontic sealers for protection against reinfection in root canal treatment and enhanced success in endodontic treatment overall.
キーワード bioactive sealer graphene oxide mineral deposition antimicrobial activity radiopacity
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-12
76巻
6号
出版者 Okayama University Medical School
開始ページ 715
終了ページ 721
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 36549774
Web of Science KeyUT 000905195100012
JaLCDOI 10.18926/AMO/64121
フルテキストURL 76_6_705.pdf
著者 Higashikawa, Toshihiro| Ito, Tomohiko| Mizuno, Takurou| Ishigami, Keiichiro| Kuroki, Kengo| Maekawa, Naoto| Usuda, Daisuke| Izumida, Toshihide| Yamada, Shinya| Sangen, Ryusho| Hamada, Kazu| Kiyosawa, Jun| Saito, Atsushi| Iguchi, Masaharu| Kasamaki, Yuji| Nakahashi, Takeshi| Fukuda, Akihiro| Saito, Hitoshi| Kanda, Tsugiyasu| Okuro, Masashi|
抄録 The sodium glucose transporter 2 (SGLT2) inhibitor tofogliflozin is a glucose-lowering drug that causes the excretion of surplus glucose by inhibiting SGLT2. Because of tofogliflozin’s osmotic diuresis mechanism, patients’ serum electrolytes, body fluid levels, and cardiac function must be monitored. We retrospectively analyzed the cases of 64 elderly Japanese patients with type 2 diabetes mellitus (T2DM) who received tofogliflozin for 3 months. Their HbA1c, serum electrolytes (sodium, potassium, chloride), hematocrit, brain natriuretic peptide (cardiac volume load marker) and renin and aldosterone (RAA; an index of regulatory hormones involved in body fluid retention) were continuously monitored during the investigation period. Renal function and cardiac function (by echocardiography) were assessed throughout the period. HbA1c significantly decreased (β1=−0.341, p<0.0001, linear regression analysis [LRA]). Most of the hormonal, electrolyte, and physiological parameters were maintained throughout the study period. In these circumstances, E/e’ tended to decrease (β1=−0.382, p=0.13, LRA). Compared to the baseline, E/e’ was significantly decreased at 1 and 3 months (p<0.01, p<0.05). In the higher E/e’ group (E/e’≥10, n=34), E/e’ decreased significantly (β1=−0.63, p<0.05, LRA). ΔE/e’ was correlated with body-weight change during treatment (r=0.64, p<0.01). The 3-month tofogliflozin treatment improved glycemic control and diastolic function represented by E/e’ in T2DM patients, without affecting serum electrolytes, renal function, or RAA. No negative impacts on the patients were observed. Three-month tofogliflozin treatment lowered glucose and improved cardiac diastolic function.
キーワード tofogliflozin SGLT2 inhibitor elderly patient HbA1c cardiac diastolic function
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-12
76巻
6号
出版者 Okayama University Medical School
開始ページ 705
終了ページ 713
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 36549773
Web of Science KeyUT 000905195100011