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JaLCDOI 10.18926/AMO/62806
フルテキストURL 75_6_677.pdf
著者 Tani Kazumasa| Mitsui, Takashi| Mishima, Sakurako| Ohira, Akiko| Maki, Jota| Eto, Eriko| Hayata, Kei| Nakamura, Keiichiro| Masuyama, Hisashi|
抄録 Extravillous trophoblast (EVT) invasion is important for embryo implantation, placental development, and successful remodeling of the uterine spiral artery. Endocrine gland derived-vascular endothelial growth factor (EG-VEGF) and matrix metalloproteinases (MMPs) are implicated in EVT invasion; however, the high con-centrations found in pregnancy pathologies have not been investigated in non-tumor trophoblasts. The roles of EG-VEGF, prokineticin receptors (PROKR1/2), MMP-2, and MMP-9 in EVT invasion during spiral artery remodeling were evaluated using human EVT from HTR-8/SVneo cell lines. The expression of MMP-2, MMP-9, and mitogen-activated protein kinase (MAPK), and Akt pathways in HTR-8/SVneo cells treated with recom-binant EG-VEGF alongside anti-PROKR1 and/or anti-PROKR2 antibodies was evaluated using quantitative reverse transcription-PCR and western blotting. Wound-healing and cell invasion assays were performed to assess the migration and invasion of these treated cells. Interestingly, 20 nM EG-VEGF activated ERK1/2 sig-naling and upregulated MMP-2 and MMP-9. This effect was suppressed by anti-PROKR2 antibody via ERK1/2 downregulation. Anti-PROKR2 antibody inhibited the migration and invasion of EG-VEGF-stimulated HTR-8/SVneo cells. Elevated concentrations of EG-VEGF enhance EVT invasion in a human trophoblast cell line by upregulating MMP-2 and MMP-9 via PROKR2. These new insights into the regulation of epithelial cell invasion may help in developing therapeutic interventions for placental-related diseases during pregnancy.
キーワード endocrine gland-derived vascular endothelial growth factor prokineticin extravillous trophoblast matrix metalloproteinase obstetric diseases
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2021-12
75巻
6号
出版者 Okayama University Medical School
開始ページ 677
終了ページ 684
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34955534
Web of Science KeyUT 000735297900002
NAID 120007180286
フルテキストURL fulltext.pdf
著者 Inai, Ryota| Nakahara, Ryuichi| Morimitsu, Yusuke| Akagi, Noriaki| Marukawa, Youhei| Matsushita, Toshi| Tanaka, Takashi| Tada, Akihiro| Hiraki, Takao| Nasu, Yoshihisa| Nishida, Keiichiro| Ozaki, Toshifumi| Kanazawa, Susumu|
キーワード Osteoporosis Bone density Tomography (x-ray computed) X-ray microtomography
発行日 2021-01-28
出版物タイトル European Radiology Experimental
4巻
1号
出版者 Springer nature
開始ページ 4
ISSN 2509-9280
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s). 2020
論文のバージョン publisher
PubMed ID 31993864
DOI 10.1186/s41747-019-0135-0
Web of Science KeyUT 000705622700001
関連URL isVersionOf https://doi.org/10.1186/s41747-019-0135-0
フルテキストURL fulltext20211019-1.pdf
著者 Miyajima, Mizuki| Astuti, Fahmi| Fukuda, Takahito| Kodani, Masashi| Iida, Shinsuke| Asai, Shinichiro| Matsuo, Akira| Masuda, Takatsugu| Kindo, Koichi| Hasegawa, Takumi| Kobayashi, Tatsuo C.| Nakano, Takehito| Watanabe, Isao| Kambe, Takashi|
発行日 2021-10-7
出版物タイトル Physical Review B
104巻
14号
出版者 American Physical Society (APS)
開始ページ L140402
ISSN 2469-9950
NCID AA11187113
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 ©2021 American Physical Society
論文のバージョン publisher
DOI 10.1103/physrevb.104.l140402
Web of Science KeyUT 000704785600002
関連URL isVersionOf https://doi.org/10.1103/physrevb.104.l140402
フルテキストURL fulltext20211015-2.pdf
著者 Seetasang, Sasikarn| Kaneta, Takashi|
キーワード Diquat Dithiothreitol Light-emitting diode Paraquat Photometric detector Sodium dithionite
備考 © 2021 Published by Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.microc.2021.106777] .
This fulltext is available in Sep. 2023.|
発行日 2021-12
出版物タイトル Microchemical Journal
171巻
出版者 Elsevier BV
開始ページ 106777
ISSN 0026-265X
NCID AA00738394
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 Published by Elsevier B.V.
論文のバージョン author
DOI 10.1016/j.microc.2021.106777
Web of Science KeyUT 000701672500002
関連URL isVersionOf https://doi.org/10.1016/j.microc.2021.106777
フルテキストURL fulltext20211006-2a.pdf
著者 Kamada, Yasuhiko| Kusumoto, Rie| Kashino, Chiaki| Kubo, Kotaro| Mitsui, Takashi| Masuyama, Hisashi|
キーワード double cross plasty genital chronic graft-versus-host disease hematocolpos hematopoietic stem cell transplantation vaginal reconstruction
備考 This is the peer reviewed version of the following article: [Kamada, Y., Kusumoto, R., Kashino, C., Kubo, K., Mitsui, T., & Masuyama, H. (2021). Surgically treated genital chronic graft‐versus‐host disease in women: A report of three cases. Journal of Obstetrics and Gynaecology Research.], which has been published in final form at [https://doi.org/10.1111/jog.15005]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-ArchivedVersions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wileyor by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked toWiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof bythird parties from platforms, services and websites other than Wiley Online Library must be prohibited.|
発行日 2021-09-05
出版物タイトル Journal of Obstetrics and Gynaecology Research
47巻
11号
出版者 Wiley
開始ページ 4122
終了ページ 4126
ISSN 1341-8076
NCID AA11082002
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 Japan Society of Obstetrics and Gynecology
論文のバージョン author
PubMed ID 34482585
DOI 10.1111/jog.15005
Web of Science KeyUT 000697443000001
関連URL isVersionOf https://doi.org/10.1111/jog.15005
フルテキストURL fulltext.pdf
著者 Obara, Takafumi| Naito, Hiromichi| Tsukahara, Kohei| Matsumoto, Naomi| Yamamoto, Hirotsugu| Yorifuji, Takashi| Nakao, Atsunori|
キーワード sleep habits trauma problematic behavior longitudinal study
発行日 2021-09-09
出版物タイトル International Journal of Environmental Research
18巻
18号
出版者 MDPI
開始ページ 9512
ISSN 1660-4601
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 by the authors.
論文のバージョン publisher
PubMed ID 34574435
DOI 10.3390/ijerph18189512
Web of Science KeyUT 000699559600001
関連URL isVersionOf https://doi.org/10.3390/ijerph18189512
フルテキストURL fulltext.pdf
著者 Matsumoto, Naomi| Kadowaki, Tomoka| Tsukahara, Hirokazu| Yorifuji, Takashi|
キーワード dental caries influenza birth cohort oral health
発行日 2021-09-06
出版物タイトル Children-Basel
8巻
9号
出版者 MDPI
開始ページ 780
ISSN 2227-9067
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 by the authors.
論文のバージョン publisher
PubMed ID 34572212
DOI 10.3390/children8090780
Web of Science KeyUT 000699412100001
関連URL isVersionOf https://doi.org/10.3390/children8090780
フルテキストURL fulltext.pdf
著者 Naito, Hiromichi| Yumoto, Tetsuya| Yorifuji, Takashi| Nojima, Tsuyoshi| Yamamoto, Hirotsugu| Yamada, Taihei| Tsukahara, Kohei| Inaba, Mototaka| Nishimura, Takeshi| Uehara, Takenori| Nakao, Atsunori|
キーワード Mortality Trauma care Cardiac arrest Time-to-treatment
発行日 2021-09-16
出版物タイトル BMC Emergency Medicine
21巻
1号
出版者 BMC
開始ページ 104
ISSN 1471-227X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s). 2021
論文のバージョン publisher
PubMed ID 34530735
DOI 10.1186/s12873-021-00499-z
Web of Science KeyUT 000696533900001
関連URL isVersionOf https://doi.org/10.1186/s12873-021-00499-z
フルテキストURL fulltext.pdf
著者 Nishida, Takashi| Akashi, Sho| Takigawa, Masaharu| Kubota, Satoshi|
キーワード angiotensin II cellular communication network factor 2 (CCN2) renin-angiotensin system (RAS) losartan angiotensin II type I receptor (AT(1)R)
発行日 2021-08-25
出版物タイトル International Journal of Molecular Sciences
22巻
17号
出版者 MDPI
開始ページ 9204
ISSN 1422-0067
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 by the authors.
論文のバージョン publisher
PubMed ID 34502113
DOI 10.3390/ijms22179204
Web of Science KeyUT 000694359000001
関連URL isVersionOf https://doi.org/10.3390/ijms22179204
フルテキストURL fulltext.pdf
著者 Kikuchi, Masuzu| Kojima, Keiichi| Nakao, Shin| Yoshizawa, Susumu| Kawanishi, Shiho| Shibukawa, Atsushi| Kikukawa, Takashi| Sudo, Yuki|
発行日 2021-07-20
出版物タイトル Scientific Reports
11巻
1号
出版者 Nature Portfolio
開始ページ 14765
ISSN 2045-2322
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2021
論文のバージョン publisher
PubMed ID 34285294
DOI 10.1038/s41598-021-94181-w
Web of Science KeyUT 000692201200025
関連URL isVersionOf https://doi.org/10.1038/s41598-021-94181-w
JaLCDOI 10.18926/AMO/62406
フルテキストURL 75_4_523.pdf
著者 Yamashita, Mampei| Kuroki, Tamotsu| Matsuoka, Yuki| Miura, Shiro| Hamada, Takashi| Hirayama, Takanori| Yoneda, Akira| Tokunaga, Takayuki| Yamanouchi, Kosho| Takeshita, Hiroaki| Maeda, Shigeto|
抄録 Acute mesenteric ischemia (AMI) is often caused by superior mesenteric artery (SMA) embolization. We report a rare case of synchronous celiac axis and SMA embolization in an elderly woman with initially mild abdominal pain. Ultimately, a second contrast-enhanced computed tomography revealed extensive necrosis from the stomach to the transverse colon together with liver ischemia due to hours of occlusion. Multiorgan failure made palliation the only option, and she died the following evening. Autopsy revealed a fragile atherosclerosis-asso-ciated thrombus. Careful examination and repeat diagnostic tests should be performed in patients with mild abdominal symptoms at risk for AMI.
キーワード atherosclerosis celiac axis mesenteric ischemia superior mesenteric artery thromboembolism
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2021-08
75巻
4号
出版者 Okayama University Medical School
開始ページ 523
終了ページ 527
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34511621
Web of Science KeyUT 000709282300007
NAID 120007146032
JaLCDOI 10.18926/AMO/62400
フルテキストURL 75_4_479.pdf
著者 Harada, Akio| Kawai, Nobuyuki| Ogawa, Tomoya| Hatakeyama, Tetsuhiro| Tamiya, Takashi|
抄録 Instances of traumatic brain injury (TBI) in the elderly have been increasing along with the aging of popula-tions. In the present study, we examined the effect of aging on long-term multidisciplinary in-patient rehabili-tation efficacy after TBI. Sixty-three patients with physical and cognitive impairments after TBI were enrolled in this study. Patients were divided into 4 age groups (≤ 24, 25-44, 45-64, ≥ 65 years) and the clinical charac-teristics and rehabilitation efficacy of each age group were determined. Functional disability was evaluated using motor and cognitive Functional Independence Measure (FIM) scores. Rehabilitation efficacy was assessed by FIM gains during rehabilitation and compared among the groups. There were no statistically significant dif-ferences in motor and cognitive FIM gains among the age groups. However, cognitive FIM gain was limited in a subset of ≥ 65 patients, and initial cognitive measures could not predict cognitive FIM improvement. These results indicate that chronological age is insufficient to accurately predict rehabilitation efficacy in older TBI patients, and that such patients should be considered candidates for intensive rehabilitation programs based on these results. Accurate prognostication of rehabilitation efficacy with continuing data collection is important when using rehabilitation resources for older TBI patients.
キーワード aging Functional Independence Measure physical and cognitive impairments traumatic brain injury rehabilitation
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2021-08
75巻
4号
出版者 Okayama University Medical School
開始ページ 479
終了ページ 486
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34511615
Web of Science KeyUT 000709282300001
NAID 120007146043
JaLCDOI 10.18926/AMO/62398
フルテキストURL 75_4_461.pdf
著者 Murakami, Hiroyuki| Yoshioka, Takanori| Moriyama, Takashi| Ishikawa, Tatsunori| Makita, Masanori| Sunami, Kazutaka|
抄録 Bendamustine plus rituximab (B-R) is an effective therapy for relapsed or refractory (r/r) low-grade B-cell lymphoma (LGBCL) and mantle cell lymphoma (MCL); however, clinical data from Japanese patients treated with B-R therapy are limited. We retrospectively evaluated the efficacy and safety of B-R therapy in 42 patients who received B-R therapy at our hospital for r/r LGBCL and MCL. All patients received intravenous (IV) ritux-imab 375 mg/m2 on day 1 and IV bendamustine 90 mg/m2 on days 2 and 3 every 28 days for up to 6 cycles. The common histologic subtypes were follicular lymphoma (n = 29, 70%), marginal zone lymphoma (n = 6, 14%), and MCL (n = 5, 12%). The overall response rate was 93%, with 62% complete response and complete response unconfirmed. The median progression-free survival (PFS) was 38 months (95% confidence interval [CI], 24.6 to not reached [NR]), and the median overall survival (OS) was 80 months (95% CI, 60.7 to NR). Patients receiving a cumulative dose of bendamustine ≥ 720 mg/m2 showed a significantly longer PFS and OS. Grade 3/4 adverse events (≥ 10%) included neutropenia (55%), lymphopenia (69%), and nausea (24%). B-R therapy was effective and well tolerated, and the cumulative dose of bendamustine was associated with a favorable outcome.
キーワード bendamustine low grade B-cell lymphoma mantle cell lymphoma
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2021-08
75巻
4号
出版者 Okayama University Medical School
開始ページ 461
終了ページ 469
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34511613
Web of Science KeyUT 000697944600008
NAID 120007146041
JaLCDOI 10.18926/AMO/62395
フルテキストURL 75_4_439.pdf
著者 Mitsui, Takashi| Mishima, Sakurako| Tani, Kazumasa| Maki, Jota| Eto, Eriko| Hayata, Kei| Masuyama, Hisashi|
抄録 Early diagnosis and therapy are important in a cesarean scar pregnancy (CSP), which can cause uterine rupture with resultant massive bleeding. However, there are some reports of CSPs continued to term. The optimal management of CSPs remains unclear; therefore, we investigated the clinical courses of CSPs diagnosed and treated at perinatal institutions in the Chugoku and Shikoku regions of Japan. We enrolled 60 women diag-nosed with CSP at 21 institutions from January 2006 to December 2015. Of the 60 women diagnosed with CSP, 57 were treated. Pregnancy was terminated in 48 women and continued in 9. Thirteen women underwent transabdominal hysterectomy; they experienced no postoperative complications or allogeneic blood transfu-sion. Nine women received therapies such as dilation and curettage, and 26 received non-surgical therapies such as methotrexate and topical administration of potassium chloride. Among 9 women who chose to con-tinue with their CSP, 7 successfully delivered newborns, 2 had uterine ruptures in the second trimester, and all women required transabdominal hysterectomy. Diagnosis and therapy in the first trimester of pregnancy are important in the management strategy of a CSP. When continuing a CSP, the risk of uterine rupture and trans-abdominal hysterectomy must be considered.
キーワード cesarean scar pregnancy uterine rupture hysterectomy methotrexate potassium chloride
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2021-08
75巻
4号
出版者 Okayama University Medical School
開始ページ 439
終了ページ 445
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34511610
Web of Science KeyUT 000697944600005
NAID 120007146038
フルテキストURL fulltext.pdf
著者 Ichikawa, Keishi| Miyoshi, Toru| Osawa, Kazuhiro| Miki, Takashi| Morimitsu, Yusuke| Akagi, Noriaki| Nakashima, Mitsutaka| Ito, Hiroshi|
キーワード coronary computed tomography angiography non-alcoholic fatty liver disease perivascular coronary inflammation
発行日 2021-08-27
出版物タイトル Medicine
100巻
34号
出版者 Lippincott Williams & Wilkins
開始ページ e27043
ISSN 0025-7974
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 the Author(s).
論文のバージョン publisher
PubMed ID 34449489
DOI 10.1097/MD.0000000000027043
Web of Science KeyUT 000691370700047
関連URL isVersionOf https://doi.org/10.1097/MD.0000000000027043
フルテキストURL fulltext.pdf
著者 Yamamoto, Norio| Sukegawa, Shintaro| Yamashita, Kazutaka| Manabe, Masaki| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Ozaki, Toshifumi| Kawasaki, Keisuke| Nagatsuka, Hitoshi| Furuki, Yoshihiko| Yorifuji, Takashi|
キーワード patient variables osteoporosis deep learning convolutional neural network ensemble model effect size
発行日 2021-08-20
出版物タイトル Medicina-Lithuania
57巻
8号
出版者 MDPI
開始ページ 846
ISSN 1010-660X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 by the authors.
論文のバージョン publisher
PubMed ID 34441052
DOI 10.3390/medicina57080846
Web of Science KeyUT 000689547600001
関連URL isVersionOf https://doi.org/10.3390/medicina57080846
フルテキストURL fulltext.pdf
著者 Hutami, Islamy Rahma| Izawa, Takashi| Khurel-Ochir, Tsendsuren| Sakamaki, Takuma| Iwasa, Akihiko| Tanaka, Eiji|
キーワード HIF1 M1/M2 macrophage S1P wound healing
発行日 2021-08-20
出版物タイトル International Journal of Molecular Sciences
22巻
16号
出版者 MDPI
開始ページ 8992
ISSN 1422-0067
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 by the authors.
論文のバージョン publisher
PubMed ID 34445695
DOI 10.3390/ijms22168992
Web of Science KeyUT 000689169900001
関連URL isVersionOf https://doi.org/10.3390/ijms22168992
フルテキストURL fulltext.pdf
著者 Yoshikawa, Yuri| Izawa, Takashi| Hamada, Yusaku| Takenaga, Hiroko| Wang, Ziyi| Ishimaru, Naozumi| Kamioka, Hiroshi|
発行日 2021-07-21
出版物タイトル Scientific Reports
11巻
1号
出版者 Nature Portfolio
開始ページ 14927
ISSN 2045-2322
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2021
論文のバージョン publisher
PubMed ID 34290363
DOI 10.1038/s41598-021-94470-4
Web of Science KeyUT 000687318300008
関連URL isVersionOf https://doi.org/10.1038/s41598-021-94470-4
フルテキストURL fulltext20210811-16.pdf
著者 Ishihara, Takashi| Sato, Masaya| Yamauchi, Toshihiro|
キーワード Malicious Websites Blacklist Web-based Attack Android
備考 © 2020 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
This fulltext is available in Nov. 2022.|
7th International Workshop on Information and Communication Security (WICS 2020), Naha, Japan, 24-27 Nov. 2020|
発行日 2020-11
出版物タイトル 2020 Eighth International Symposium on Computing and Networking Workshops (CANDARW)
出版者 IEEE
開始ページ 20489448
資料タイプ 会議発表論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2020 IEEE
論文のバージョン author
DOI 10.1109/candarw51189.2020.00070
関連URL isVersionOf https://doi.org/10.1109/candarw51189.2020.00070
フルテキストURL fulltext.pdf
著者 Hongo, Takashi| Naito, Hiromichi| Fujiwara, Toshifumi| Naito, Takaki| Homma, Yosuke| Fujimoto, Yoshihisa| Takaya, Morooka| Yamamori, Yuji| Nakada, Taka-Aki| Nojima, Tsuyoshi| Nakao, Atsunori| Fujitani, Shigeki| In-Hospital Emergency Study Group|
キーワード discharge to home DNAR RRS serious adverse event
発行日 2021-08-16
出版物タイトル Acute Medicine & Surgery
8巻
1号
出版者 Wiley
開始ページ e690
ISSN 2052-8817
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 The Authors.
論文のバージョン publisher
DOI 10.1002/ams2.690
Web of Science KeyUT 000685164200001
関連URL isVersionOf https://doi.org/10.1002/ams2.690