検索結果 - 岡山大学学術成果リポジトリ

PD-L1 expression combined with microsatellite instability/CD8+ tumor infiltrating lymphocytes as a useful prognostic biomarker in gastric cancer

フルテキストURL	K0006030_abstract_review.pdf K0006030_fulltext.pdf K0006030_other_1 supplemantary Information.pdf
著者	森廣俊昭\|
発行日	2019-09-25
資料タイプ	学位論文
学位授与番号	甲第6030号
学位授与年月日	2019-09-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

The epithelial-to-mesenchymal transition induced by tumor-associated macrophages confers chemoresistance in peritoneally disseminated pancreatic cancer

フルテキストURL	K0006029_abstract_review.pdf K0006029_fulltext.pdf
著者	桒田和也\|
発行日	2019-09-25
資料タイプ	学位論文
学位授与番号	甲第6029号
学位授与年月日	2019-09-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

Urine 5MedC, a Marker of DNA Methylation, in the Progression of Chronic Kidney Disease

フルテキストURL	K0006028_abstract_review.pdf K0006028_fulltext_org.pdf K0006028_summary.pdf
著者	大西章史\|
発行日	2019-09-25
資料タイプ	学位論文
学位授与番号	甲第6028号
学位授与年月日	2019-09-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語
著作権者	© 2019 Akifumi Onishi et al.

Use of single-dose perioperative antimicrobial therapy is acceptable in recipients of living-donor renal transplants in the rituximab era

フルテキストURL	K0006026_abstract_review.pdf K0006026_fulltext.pdf
著者	西村慎吾\|
発行日	2019-09-25
資料タイプ	学位論文
学位授与番号	甲第6026号
学位授与年月日	2019-09-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

δ-Catenin Promotes Bevacizumab-Induced Glioma Invasion

フルテキストURL	K0006025_abstract_review.pdf K0006025_fulltext.pdf
著者	清水俊彦\|
発行日	2019-09-25
資料タイプ	学位論文
学位授与番号	甲第6025号
学位授与年月日	2019-09-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

Photoimmunotherapy for cancer-associated fibroblasts targeting fibroblast activation protein in human esophageal squamous cell carcinoma

フルテキストURL	K0006024_abstract_review.pdf K0006024_fulltext.pdf K0006024_other_1 figure.pdf K0006024_other_2 Supplementary figures and legends.pdf
著者	渡邉伸一郎\|
発行日	2019-09-25
資料タイプ	学位論文
学位授与番号	甲第6024号
学位授与年月日	2019-09-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

The Golgin Protein Giantin Regulates Interconnections Between Golgi Stacks

フルテキストURL	fcell_2019_00160_p.pdf fcell_2019_00160_a.pdf
著者	Satoh, Ayano\| Hayashi-Nishino, Mitsuko\| Shakuno, Takuto\| Masuda, Junko\| Koreishi, Mayuko\| Murakami, Runa\| Nakamura, Yoshimasa\| Nakamura, Toshiyuki\| Abe-Kanoh, Naomi\| Honjo, Yasuko\| Malsam, Joerg\| Yu, Sidney\| ishino, Kunihiko \|
キーワード	Golgi golgins glycosylation endoplasmic reticulum electron tomography
発行日	2019-08-27
出版物タイトル	Frontiers in Cell and Developmental Biology
巻	7巻
開始ページ	160
ISSN	2296634X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	publisher
PubMed ID	31544102
DOI	10.3389/fcell.2019.00160
関連URL	isVersionOf https://doi.org/10.3389/fcell.2019.00160

Photochemical Characterization of a New Heliorhodopsin from the Gram-Negative Eubacterium Bellilinea caldifistulae (BcHeR) and Comparison with Heliorhodopsin-48C12

フルテキストURL	Biochemistry_58_26_2934.pdf
著者	Shibukawa, Atsushi\| Kojima, Keiichi\| Nakajima, Yu\| Nishimura, Yosuke\| Yoshizawa, Susumu\| Sudo, Yuki\|
備考	This fulltext will be available in Jun 2020\|
発行日	2019-05-31
出版物タイトル	Biochemistry
巻	58巻
号	26号
出版者	American Chemical Society
開始ページ	2934
終了ページ	2943
ISSN	00062960
NCID	AA00564599
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	31150215
DOI	10.1021/acs.biochem.9b00257
関連URL	isVersionOf https://doi.org/10.1021/acs.biochem.9b00257

Quantitation of the neural silencing activity of anion channelrhodopsins in Caenorhabditis elegans and their applicability for long-term illumination

フルテキストURL	SciRep_9_7863.pdf
著者	Yamanashi, Taro\| Maki, Misayo\| Kojima, Keiichi\| Shibukawa, Atsushi\| Tsukamoto, Takashi\| Chowdhury, Srikanta\| Yamanaka, Akihiro\| Takagi, Shin\| Sudo, Yuki\|
発行日	2019-05-27
出版物タイトル	Scientific reports
巻	9巻
号	1号
出版者	Nature Publishing Group
開始ページ	7863
ISSN	20452322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	publisher
PubMed ID	31133660
DOI	10.1038/s41598-019-44308-x
関連URL	isVersionOf https://doi.org/10.1038/s41598-019-44308-x

Enhancement of optical force acting on vesicles via the binding of gold nanoparticles

フルテキストURL	RSocOpenSci_6_5_190293_p.pdf
著者	Tani, Yumeki\| Kaneta, Takashi\|
キーワード	gold nanoparticle optical force vesicles
発行日	2019-05-15
出版物タイトル	Royal Society Open Science
巻	6巻
号	5号
出版者	Royal Society Publishing
開始ページ	190293
ISSN	20545703
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	publisher
PubMed ID	31218066
DOI	10.1098/rsos.190293
関連URL	isVersionOf https://doi.org/10.1098/rsos.190293

Laser-Induced Fluorometry for Capillary Electrophoresis

フルテキストURL	ChemRec_19_2_3_452.pdf
著者	Kaneta, Takashi\|
キーワード	DNA sequencing capillary electrophoresis laser-induced fluorescence micellar electrokinetic chromatography
発行日	2018-08-06
出版物タイトル	Chemical Record
巻	19巻
号	2-3号
出版者	Wiley
開始ページ	452
終了ページ	461
ISSN	15278999
NCID	AA11515019
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	30079538
DOI	10.1002/tcr.201800051
関連URL	isVersionOf https://doi.org/10.1002/tcr.201800051

Characterization of burdock mottle virus, a novel member of the genus Benyvirus, and the identification of benyvirus-related sequences in the plant and insect genomes.

フルテキストURL	VirusRes_177_1_75.pdf Table 1-revised.pdf FigS-revised.pdf Figs_revised.pdf Table S.pdf
著者	Kondo, Hideki\| Hirano, Shuichi\| Chiba, Sotaro\| Andika, Ida Bagus\| Hirai, Makoto\| Maeda, Takanori\| Tamada, Tetsuo\|
キーワード	AlkB Benyvirus Burdock mottle virus Endogenous viral element Paleovirology Transcriptome shotgun assembly
発行日	2013-10
出版物タイトル	Virus Research
巻	177巻
号	1号
出版者	Elsevier Science
開始ページ	75
終了ページ	86
ISSN	01681702
NCID	AA10642076
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	23911632
DOI	10.1016/j.virusres.2013.07.015
Web of Science KeyUT	000324974100009
関連URL	isVersionOf https://doi.org/10.1016/j.virusres.2013.07.015

Sequence and phylogenetic analyses of novel totivirus-like double-stranded RNAs from field-collected powdery mildew fungi

フルテキストURL	VirusRes_213_353.pdf tables_revised.pdf Fig S.pdf Supplementary_tables_revised.pdf
著者	Kondo, Hideki\| Hisano, Sakae\| Chiba, Sotaro\| Maruyama, Kazuyuki\| Andika, Ida Bagus\| Toyoda, Kazuhiro\| Fujimori, Fumihiro\| Suzuki, Nobuhiro\|
キーワード	Deep sequencing Double stranded RNA virus Powdery mildew Saccharomyces cerevisiae virus L-A Totivirus Ustilago maydis virus H1
発行日	2016-02
出版物タイトル	Virus Research
巻	213巻
出版者	Elsevier Science
開始ページ	353
終了ページ	364
ISSN	01681702
NCID	AA10642076
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	26592174
DOI	10.1016/j.virusres.2015.11.015
Web of Science KeyUT	000371840600042
関連URL	isVersionOf https://doi.org/10.1016/j.virusres.2015.11.015

Phase II Trial Using Romidepsin after Gemcitabine, Dexamethasone, and Cisplatin Therapy in Elderly Transplant-Ineligible Patients with Relapsed/Refractory Peripheral T-Cell Lymphoma: Study Protocol

JaLCDOI	10.18926/AMO/57379
フルテキストURL	73_5_469.pdf
著者	Yamasaki, Satoshi\| Kada, Akiko\| Nagai, Hirokazu\| Yoshida, Isao\| Choi, Ilseung\| Saito, Akiko M.\| Iwasakia, Hiromi\|
抄録	Romidepsin is an important therapeutic option for patients with peripheral T-cell lymphoma (PTCL). However, the timing of romidepsin administration remains controversial. Romidepsin was launched in Japan as a consolidation therapy agent after conventional salvage chemotherapy with gemcitabine, dexamethasone, and cisplatin (GDP). GDP therapy will be administered every 3 weeks. If complete response, partial response, or stable disease is confirmed after 2-4 GDP cycles, romidepsin will be administered every 4 weeks. The primary endpoint is a 2-year progression-free survival rate. Patients participating in this study and undergoing treatment can expect results similar to or better than those of conventional therapies.
キーワード	peripheral T-cell lymphoma not otherwise specified angioimmunoblastic T-cell lymphoma gemcitabine cisplatin, romidepsin
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2019-10
巻	73巻
号	5号
出版者	Okayama University Medical School
開始ページ	469
終了ページ	474
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31649375
Web of Science KeyUT	000491886600014

A Granulation Polyp in the Colon Masquerading as Metastatic Cancer

JaLCDOI	10.18926/AMO/57377
フルテキストURL	73_5_457.pdf
著者	Iwamuro, Masaya\| Takahara, Masahiro\| Yamazaki, Tatsuhiro\| Tanaka, Takehiro\| Kondo, Yoshitaka\| Hiraoka, Sakiko\| Okada, Hiroyuki\|
抄録	A 60-year-old Caucasian male was diagnosed with lung adenocarcinoma and multiple metastases to the bone, spleen, and brain. He underwent radiotherapy for the brain and lumbar spine metastases, plus chemotherapy (cisplatin and pemetrexed). The chemotherapy was discontinued due to vomiting and hyponatremia, and nivolumab was then administered. Eight months later, 18F-fluorodeoxyglucose positron emission tomography showed tracer uptake in the colon. Colonoscopy revealed a reddish multinodular polyp in the sigmoid colon. The polyp showed irregular microvessels. No colonic mucosal surface structures were observed. Colonic metastasis of the lung carcinoma was highly suspected; the polyp was therefore surgically removed. The histological analysis revealed granulation tissue and suppurative inflammation without neoplastic changes. We diagnosed the lesion as a granulation polyp. Despite the difficulty in diagnosing these lesions due to their rarity and similarity to metastatic colon tumors, we suggest that recognizing the endoscopic features of the polyp surface may allow a preoperative diagnosis.
キーワード	colonoscopy colonic neoplasms granulation polyp
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2019-10
巻	73巻
号	5号
出版者	Okayama University Medical School
開始ページ	457
終了ページ	461
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31649373
Web of Science KeyUT	000491886600012

Acute Prevertebral Abscesses Caused by Bacterial-infected Traumatic Tooth Fractures

JaLCDOI	10.18926/AMO/57376
フルテキストURL	73_5_449.pdf
著者	Matsunaga, Kazuyuki\| Takemaru, Makoto\| Yamashiro, Keisuke\| Yoshihara-Hirata, Chiaki\| Inohara, Ken\| Shimoe, Yutaka\| Tanaka, Akio\| Kuriyama, Masaru\| Takashiba, Shogo\|
抄録	We report a case of acute prevertebral abscess caused by traumatic tooth fractures in a 77-year-old Japanese man. After being transferred to our hospital the patient was initially diagnosed with a neck hematoma; however, blood culture showed Streptococcus parasanguinis, an oral bacterium, and an MRI examination suggested prevertebral abscesses. Tooth fractures, severe periodontitis, and peri-implantitis with Streptococcus parasanguinis were observed. Antibiotics were administered and fractured teeth were extracted. The patient's condition then gradually improved. We concluded that bacteremia caused by traumatic tooth fractures induced the acute prevertebral abscesses.
キーワード	prevertebral abscess deep neck infection periodontal disease peri-implantitis Streptococcus parasanguinis
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2019-10
巻	73巻
号	5号
出版者	Okayama University Medical School
開始ページ	449
終了ページ	456
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31649372
Web of Science KeyUT	000491886600011

Relationship between Intracellular Signaling of the (Pro)renin Receptor and the Pathogenesis of Preeclampsia

JaLCDOI	10.18926/AMO/57374
フルテキストURL	73_5_433.pdf
著者	Tamada, Shoko\| Mitsui, Takashi\| Ohira, Akiko\| Tani, Kazumasa\| Maki, Jota\| Eguchi, Takeshi\| Eto, Eriko\| Hayata, Kei\| Masuyama, Hisashi\|
抄録	An association between preeclampsia and (pro)renin was recently reported. Intracellular signaling of the (pro) renin receptor [(P)RR] increases the expressions of TGF-β and PAI-1. In this study we sought to clarify the involvement of (pro)renin in the pathogenesis of preeclampsia via the intracellular signaling of (P)RR on preeclampsia placentas. Activated (pro)renin plasma concentrations were compared between pregnant women with (n=15) and without (n=28) preeclampsia. The placentas were immunohistochemically evaluated with anti-HIF-1α and anti-(P)RR antibodies. HTR-8/SVneo cells were cultured under hypoxic conditions and treated with human recombinant (pro)renin. The mRNA expressions of HIF-1α, (P)RR, PAI-1, TGF-β, and ET-1 were also examined by real-time RCR. The activated (pro)renin plasma concentration was significantly higher in the third vs. the second trimester in the preeclampsia patients. HIF-1α and (P)RR expressions were significantly increased in the preeclampsia placentas. The mRNA expressions of PAI-1, TGF-β, and ET-1 were significantly increased in the experiments using recombinant (pro)renin vs. hypoxic conditions. (P)RR expression in preeclampsia placentas is increased by persistent hypoxia through the second and third trimesters, and PAI-1, TGF-β, and ET-1 production is increased via (P)RR. Our results suggest that ET-1 production via the intracellular signaling of (P)RR is important in the pathogenesis of preeclampsia.
キーワード	preeclampsia (pro)renin (pro)renin receptor endothelin-1 HTR-8/SVneo
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-10
巻	73巻
号	5号
出版者	Okayama University Medical School
開始ページ	433
終了ページ	440
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31649370
Web of Science KeyUT	000491886600009

Risk Factors for Low Bone Mineral Density Determined in Patients in a General Practice Setting

JaLCDOI	10.18926/AMO/57370
フルテキストURL	73_5_403.pdf
著者	Ando, Akemi\| Mitsuhashi, Toshiharu\| Honda, Mitsugi\| Hanayama, Yoshihisa\| Hasegawa, Kou\| Obika, Mikako\| Kataoka, Hitomi\| Otsuka, Fumio\|
抄録	Osteoporosis increases the risk of bone fractures. It is diagnosed based on an individual’s bone mineral density (BMD) or a fracture without trauma. BMD is usually measured by the dual energy X-ray absorptiometry (DXA) method. Here we investigated factors for the earliest possible prediction of decreased BMD by examining the relationships between patients’ BMD values and changes in the patients’ physical and laboratory values. We retrospectively reviewed the medical records of 149 patients who visited our department in 2014-2015 for a variety of reasons and underwent an area BMD examination by DXA. We analyzed the relationships between decreasing BMD and the patients’ gender, age, body mass index (BMI), medical background, hemoglobin, electrolytes, and thyroid function. Thirty-nine of the patients were diagnosed with osteoporosis based on their T-scores. An adjusted analysis showed that female gender, aging, and increased serum calcium level were significantly related to decreasing femoral BMD, whereas high BMI was associated with an increase in femoral BMD. Collectively the results indicate that for the early detection of low BMD, it is important for general-practice physicians to consider conducting a BMD checkup when treating female and elderly patients with a low BMI and/or elevated serum calcium level.
キーワード	bone mineral density (BMD) body mass index (BMI) female gender hypercalcemia osteoporosis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-10
巻	73巻
号	5号
出版者	Okayama University Medical School
開始ページ	403
終了ページ	411
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31649366
Web of Science KeyUT	000491886600005

Developing Microsurgery through Experience in Yangon General Hospital, Myanmar

JaLCDOI	10.18926/AMO/57369
フルテキストURL	73_5_393.pdf
著者	Yi Yi Cho Thein\| Win, Myitzu\| Thuzara, Moe\| Matsumoto, Hiroshi\| Yamada, Kiyoshi\| Kimata, Yoshihiro\| Leung, Michael\|
抄録	Although many surgical centers perform microsurgery routinely in developed countries, performing microsurgery is challenging in resource-poor developing countries, such as Myanmar. With the establishment of educational training programs and the assistance of volunteer plastic surgical teams, local plastic surgeons can learn the techniques of microsurgery and apply them clinically. The purpose of this study was to establish baseline data and define the challenges of performing microsurgery in Yangon General Hospital, Myanmar. Sixty-four patients underwent reconstruction with free flaps from January 2015 to January 2018. All clinical records of these cases were assessed. The number of free flap reconstructions performed increased from 11 in the first year to 24 in the third year. The anterolateral thigh flap was the most commonly used (42%). The most common sites of reconstruction were mandible and intraoral defects. Total flap survival occurred in 58 of 64 patients (89%). The total salvageable flap rate for revision surgery was 66.6%; the successful revision rate was highest in 2017, with fewer complications. The flap salvage rates increased and the operative duration decreased as clinical experience improved. Establishing a microsurgical center requires a strong multidisciplinary team, clinical experience, continuous learning, sensible clinical application, and effective interdepartmental and intradepartmental cooperation.
キーワード	microsurgery educational programs challenges of microsurgical free flaps reoperation flap salvageable rate
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-10
巻	73巻
号	5号
出版者	Okayama University Medical School
開始ページ	393
終了ページ	401
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31649365
Web of Science KeyUT	000491886600004

The Role of High Mobility Group Box-1 in Epileptogenesis

JaLCDOI	10.18926/AMO/57367
フルテキストURL	73_5_383.pdf
著者	Fu, Li\| Nishibori, Masahiro\|
抄録	High mobility group box-1 (HMGB1) is a non-histone, DNA-binding nuclear protein belonging to the family of damage-associated molecular patterns (DAMPs). HMGB1 has been reported to play an important role during epileptogenesis although the mechanisms of its actions are still not clear. Many hypotheses have been suggested especially about the relationship between HMGB1 and inflammation responses and blood-brain barrier disruption during epileptogenesis. In this review, we will mainly discuss the role of HMGB1 in epileptogenesis.
キーワード	HMGB1 epileptogenesis inflammation blood-brain barrier
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2019-10
巻	73巻
号	5号
出版者	Okayama University Medical School
開始ページ	383
終了ページ	386
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31649363
Web of Science KeyUT	000491886600002