検索結果 - 岡山大学学術成果リポジトリ

Organized Chronic Subdural Hematoma (OCSDH) Mimicking Meningioma

JaLCDOI	10.18926/AMO/67204
フルテキストURL	78_3_285.pdf
著者	Hirano, Shuichiro\| Otani, Yoshihiro\| Fujii, Kentaro\| Date, Isao\|
抄録	Organized chronic subdural hematoma (OCSDH) is a relatively rare condition that forms over a longer period of time compared to chronic subdural hematoma and is sometimes difficult to diagnose with preoperative imaging. We resected an intracranial lesion in a 37-year-old Japanese man; the lesion had been increasing in size for >17 years. The preoperative diagnosis based on imaging findings was meningioma; however, pathological findings revealed OCSDH. Clinicians should be aware that OCSDH mimics other tumors and consider surgical strategies for this disease.
キーワード	meningioma organized chronic subdural hematoma
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2024-06
巻	78巻
号	3号
出版者	Okayama University Medical School
開始ページ	285
終了ページ	290
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38902217
Web of Science KeyUT	001267351900002

The specific shapes of capillaries are associated with worse prognosis in patients with invasive breast cancer

フルテキストURL	fulltext.pdf
著者	Swe, Hnin‐Wint‐Wint\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Komatsubara, Yu\| Yoshimura, Teizo\| Shien, Tadahiko\| Matsukawa, Akihiro\|
キーワード	angiogenesis blood vessels breast cancer CD31 antigen immunohistochemistry microvessel density survival analysis
発行日	2024-05-31
出版物タイトル	Pathology International
巻	74巻
号	7号
出版者	Wiley
開始ページ	394
終了ページ	407
ISSN	1320-5463
NCID	AA10984364
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 The Author(s).
論文のバージョン	publisher
PubMed ID	38818885
DOI	10.1111/pin.13442
Web of Science KeyUT	001235649700001
関連URL	isVersionOf https://doi.org/10.1111/pin.13442

Double-faced CX3CL1 enhances lymphangiogenesis-dependent metastasis in an aggressive subclone of oral squamous cell carcinoma

フルテキストURL	fulltext.pdf
著者	Eain, Htoo Shwe\| Kawai, Hotaka\| Nakayama, Masaaki\| Oo, May Wathone\| Ohara, Toshiaki\| Fukuhara, Yoko\| Takabatake, Kiyofumi\| Shan, Quisheng\| Soe, Yamin\| Ono, Kisho\| Nakano, Keisuke\| Mizukawa, Nobuyoshi\| Iida, Seiji\| Nagatsuka, Hitoshi\|
発行日	2024-05-22
出版物タイトル	JCI Insight
巻	9巻
号	10号
出版者	American Society for Clinical Investigation
開始ページ	e174618
ISSN	2379-3708
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024, Eain et al.
論文のバージョン	publisher
PubMed ID	38775151
DOI	10.1172/jci.insight.174618
Web of Science KeyUT	001230441500001
関連URL	isVersionOf https://doi.org/10.1172/jci.insight.174618

Spontaneous regression and rare relapse after excisional biopsy in long-term observation of 31 patients with primary conjunctival lymphoma

フルテキストURL	fulltext.pdf
著者	Matsuo, Toshihiko\| Tanaka, Takehiro\|
キーワード	conjunctival lymphoma extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) follicular lymphoma diffuse large B-cell lymphoma fluorodeoxyglucose positron emission tomography (FDG-PET)
発行日	2024
出版物タイトル	Journal of Clinical and Experimental Hematopathology
巻	64巻
号	2号
出版者	Japanese Society for Lymphoreticular Tissue Research
開始ページ	86
終了ページ	96
ISSN	1346-4280
NCID	AA11556796
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 The Japanese Society for Lymphoreticular Tissue Research
論文のバージョン	publisher
PubMed ID	38684405
DOI	10.3960/jslrt.24002
Web of Science KeyUT	001218537700001
関連URL	isVersionOf https://doi.org/10.3960/jslrt.24002

Trousseau's syndrome in diffuse large B-cell lymphoma

フルテキストURL	fulltext.pdf
著者	Kitamura, Wataru\| Sato, Yumiko\| Kuyama, Shoichi\|
キーワード	diffuse large B-cell lymphoma multiple cerebral infarctions Trousseau's syndrome
発行日	2023-12-15
出版物タイトル	eJHaem
巻	5巻
号	1号
出版者	Wiley
開始ページ	271
終了ページ	273
ISSN	2688-6146
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 The Authors.
論文のバージョン	publisher
PubMed ID	38406545
DOI	10.1002/jha2.837
Web of Science KeyUT	001216592400027
関連URL	isVersionOf https://doi.org/10.1002/jha2.837

Clinical application of pancreatic juice-derived small extracellular vesicles of pancreatic ductal adenocarcinoma

フルテキストURL	fulltext.pdf
著者	Tsutsumi, Koichiro\| Otsuka, Motoyuki\|
キーワード	biomarker early diagnosis high-grade PanIN IPMN liquid biopsy pancreatic ductal carcinoma pancreatic juice small extracellular vesicle treatment
発行日	2023-03-28
出版物タイトル	Clinical and Translational Discovery
巻	3巻
号	2号
出版者	Wiley
開始ページ	e177
ISSN	2768-0622
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 The Authors.
論文のバージョン	publisher
DOI	10.1002/ctd2.177
Web of Science KeyUT	001224381800004
関連URL	isVersionOf https://doi.org/10.1002/ctd2.177

Decades of stability of conjunctival vascular malformations in two patients

フルテキストURL	fulltext20240513-03.pdf
著者	Matsuo, Toshihiko\| Tanaka, Takehiro\| Kimata, Yoshihiro\|
キーワード	hemangioma lymphangioma lymphatic malformation pathology trabeculectomy vascular malformation
発行日	2024-05
出版物タイトル	Clinical Case Reports
巻	12巻
号	5号
出版者	Wiley
開始ページ	e8933
ISSN	2050-0904
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 The Authors.
論文のバージョン	publisher
PubMed ID	38741673
DOI	10.1002/ccr3.8933
Web of Science KeyUT	001218609400001
関連URL	isVersionOf https://doi.org/10.1002/ccr3.8933

Spontaneous regression of multiple solitary plasmacytoma harboring Epstein–Barr virus: a case report and literature review

フルテキストURL	fulltext20240508-02.pdf fig20240508-02.pdf table20240508-02.pdf
著者	Kitamura, Wataru\| Kobayashi, Hiroki\| Noda, Minori\| Iseki, Akiko\| Sato, Yumi\| Maeda, Yoshinobu\| Kuyama, Shoichi\|
キーワード	Plasmacytoma Epstein–Barr virus Spontaneous regression
備考	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s12185-024-03765-5\| This fulltext file will be available in Apr. 2025.\|
発行日	2024-04-15
出版物タイトル	International Journal of Hematology
巻	120巻
号	1号
出版者	Springer Science and Business Media LLC
開始ページ	128
終了ページ	134
ISSN	0925-5710
NCID	AA10797094
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Japanese Society of Hematology 2024
論文のバージョン	author
PubMed ID	38619657
DOI	10.1007/s12185-024-03765-5
Web of Science KeyUT	001204755500002
関連URL	isVersionOf https://doi.org/10.1007/s12185-024-03765-5

PD-L1-expressing cancer-associated fibroblasts induce tumor immunosuppression and contribute to poor clinical outcome in esophageal cancer

フルテキストURL	fulltext.pdf
著者	Kawasaki, Kento\| Noma, Kazuhiro\| Kato, Takuya\| Ohara, Toshiaki\| Tanabe, Shunsuke\| Takeda, Yasushige\| Matsumoto, Hijiri\| Nishimura, Seitaro\| Kunitomo, Tomoyoshi\| Akai, Masaaki\| Kobayashi, Teruki\| Nishiwaki, Noriyuki\| Kashima, Hajime\| Maeda, Naoaki\| Kikuchi, Satoru\| Tazawa, Hiroshi\| Shirakawa, Yasuhiro\| Fujiwara, Toshiyoshi\|
キーワード	Esophageal cancer Cancer-associated fibroblasts Programmed cell death 1 Program cell death ligand 1 Immune checkpoint inhibitors
備考	The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-023-03531-2\|
発行日	2023-09-05
出版物タイトル	Cancer Immunology, Immunotherapy
巻	72巻
号	11号
出版者	Springer Science and Business Media LLC
開始ページ	3787
終了ページ	3802
ISSN	0340-7004
NCID	AA00598499
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	37668710
DOI	10.1007/s00262-023-03531-2
Web of Science KeyUT	001062743200002
関連URL	isVersionOf https://doi.org/10.1007/s00262-023-03531-2

Endoscopic manifestation of intestinal transplant-associated microangiopathy after stem cell transplantation

フルテキストURL	fulltext.pdf
著者	Iwamuro, Masaya\| Ennishi, Daisuke\| Fujii, Nobuharu\| Matsuoka, Ken-Ichi\| Tanaka, Takehiro\| Inokuchi, Toshihiro\| Hiraoka, Sakiko\| Otsuka, Motoyuki\|
キーワード	Colonoscopy Esophagogastroduodenoscopy Graft-versus-host disease Hematopoietic stem cell transplantation Intestinal transplant-associated microangiopathy iTAM
備考	The version of record of this article, first published in BMC Gastroenterology, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12876-024-03221-y\|
発行日	2024-04-22
出版物タイトル	BMC Gastroenterology
巻	24巻
号	1号
出版者	BMC
開始ページ	140
ISSN	1471-230X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024.
論文のバージョン	publisher
PubMed ID	38649868
DOI	10.1186/s12876-024-03221-y
Web of Science KeyUT	001206319800003
関連URL	isVersionOf https://doi.org/10.1186/s12876-024-03221-y

Phosphorylated SARM1 is involved in the pathological process of rotenone-induced neurodegeneration

フルテキストURL	fulltext.pdf
著者	Murata, Hitoshi\| Phoo, May Tha Zin\| Ochi, Toshiki\| Tomonobu, Nahoko\| Yamamoto, Ken-ichi\| Kinoshita, Rie\| Miyazaki, Ikuko\| Nishibori, Masahiro\| Asanuma, Masato\| Sakaguchi, Masakiyo\|
キーワード	JNK PARK2 Parkinson’sdisease Phosphorylation SARM1
発行日	2023-09-19
出版物タイトル	The Journal of Biochemistry
巻	174巻
号	6号
出版者	Oxford University Press (OUP)
開始ページ	533
終了ページ	548
ISSN	0021-924X
NCID	AA00694073
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023.
論文のバージョン	publisher
PubMed ID	37725528
DOI	10.1093/jb/mvad068
Web of Science KeyUT	001079972500001
関連URL	isVersionOf https://doi.org/10.1093/jb/mvad068

Diagnostic accuracy of frozen section biopsy for early gastric cancer extent during endoscopic submucosal dissection: a prospective study

フルテキストURL	fulltext.pdf
著者	Kobashi, Mayu\| Ishikawa, Shigenao\| Inaba, Tomoki\| Iwamuro, Masaya\| Aoyama, Yuki\| Kagawa, Tomo\| Takeuchi, Yasuto\| Ando, Midori\| Nakamura, Satoko\| Okada, Hiroyuki\|
キーワード	Frozen section Pathological diagnosis Diagnostic accuracy Early gastric cancer Endoscopic submucosal dissection Lateral margin
備考	The version of record of this article, first published in Surgical Endoscopy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00464-023-10100-2\|
発行日	2023-05-22
出版物タイトル	Surgical Endoscopy
巻	37巻
号	9号
出版者	Springer Science and Business Media LLC
開始ページ	6736
終了ページ	6748
ISSN	0930-2794
NCID	AA10750363
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	37217685
DOI	10.1007/s00464-023-10100-2
Web of Science KeyUT	000993678400007
関連URL	isVersionOf https://doi.org/10.1007/s00464-023-10100-2

Prospective evaluation of core number of biopsy for renal tumor: are multiple cores preferable?

フルテキストURL	fulltext.pdf
著者	Iguchi, Toshihiro\| Matsui, Yusuke\| Toji, Tomohiro\| Sakurai, Jun\| Tomita, Koji\| Uka, Mayu\| Umakoshi, Noriyuki\| Kawabata, Takahiro\| Munetomo, Kazuaki\| Mitsuhashi, Toshiharu\| Hiraki, Takao\|
キーワード	Biopsy Kidney Tumor Computed tomography Ultrasound
備考	The version of record of this article, first published in Japanese Journal of Radiology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11604-023-01496-x\|
発行日	2023-10-14
出版物タイトル	Japanese Journal of Radiology
巻	42巻
号	3号
出版者	Springer Science and Business Media LLC
開始ページ	319
終了ページ	325
ISSN	1867-1071
NCID	AA12375935
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	37833443
DOI	10.1007/s11604-023-01496-x
Web of Science KeyUT	001086535200001
関連URL	isVersionOf https://doi.org/10.1007/s11604-023-01496-x

A Case of Gallbladder Cancer with Trousseau Syndrome Successfully Treated Using Radical Resection

JaLCDOI	10.18926/AMO/66931
フルテキストURL	78_2_201.pdf
著者	Masunaga, Akari\| Tabuchi, Motoyasu\| Sakamoto, Shinya\| Yoshimatsu, Rika\| Matsumoto, Manabu\| Iwata, Jun\| Okabayashi, Takehiro\|
抄録	Trousseau syndrome is characterized by cancer-associated systemic thrombosis. We describe the first case of a successfully treated gallbladder adenocarcinoma accompanied by Trousseau syndrome. A 66-year-old woman presented with right hemiplegia. Magnetic resonance imaging identified multiple cerebral infarctions. Her serum carbohydrate antigen 19-9 and D-dimer levels were markedly elevated, and a gallbladder tumor was detected via abdominal computed tomography. Venous ultrasonography of the lower limbs revealed a deep venous thrombus in the right peroneal vein. These findings suggested that the brain infarctions were likely caused by Trousseau syndrome associated with her gallbladder cancer. Radical resection of the gallbladder tumor was performed. The resected gallbladder was filled with mucus and was pathologically diagnosed as an adenocarcinoma. Her postoperative course was uneventful, and she received a one-year course of adjuvant therapy with oral S-1. No cancer recurrence or thrombosis was noted 26 months postoperatively. Despite concurrent Trousseau syndrome, a radical cure of the primary tumor and thrombosis could be achieved with the appropriate treatment.
キーワード	gallbladder cancer Trousseau syndrome radical surgery
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2024-04
巻	78巻
号	2号
出版者	Okayama University Medical School
開始ページ	201
終了ページ	204
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38688839
Web of Science KeyUT	001227932200001

Impact of Travel Distance on Surgical Outcomes of Patients Surgically Treated for Non-Small Cell Lung Cancer: A Single-Center Study in Ehime, Japan

JaLCDOI	10.18926/AMO/66923
フルテキストURL	78_2_143.pdf
著者	Shigematsu, Hisayuki\| Yamashita, Natsumi\| Suehisa, Hiroshi\| Ueno, Tsuyoshi\| Ryuko, Tsuyoshi\| Sugihara, Takahito\| Nakashima, Shohei\| Sano, Yoshifumi\| Yamashita, Motohiro\|
抄録	Travel burden is a poor prognostic factor for many cancers worldwide because it hinders optimal diagnosis and treatment planning. Currently, the impact of travel burden on survival after surgery for non-small cell lung cancer (NSCLC) in Japan is largely unexplored. We examined the impact of travel distance on the postoperative outcomes of patients with NSCLC in Ehime Prefecture, Japan. The data of 1212 patients who underwent surgical resection for NSCLC were retrospectively reviewed. Patients were divided into quartiles based on the travel distance from their home to the hospital (≤ 13 km, 13-40 km, 40-57 km, and > 57 km) in Ehime Prefecture. We found no significant differences among the quartiles in baseline clinicopathological characteristics, including sex, smoking status, histology, surgical procedure, clinical stage, and pathological stage. Overall survival (OS) and relapse-free survival (RFS) also were not significantly different among the travel distance quartiles. We conclude that travel distance did not impact OS or RFS among patients with NSCLC who underwent surgical resection at our institution.
キーワード	non-small cell lung cancer travel distance travel burden lung surgery surgical outcome
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-04
巻	78巻
号	2号
出版者	Okayama University Medical School
開始ページ	143
終了ページ	149
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38688832
Web of Science KeyUT	001229151800006

Copy Number Analysis of 9p24.1 in Classic Hodgkin Lymphoma Arising in Immune Deficiency/Dysregulation

フルテキストURL	fulltext.pdf
著者	Ohsawa, Kumiko\| Momose, Shuji\| Nishikori, Asami\| Nishimura, Midori Filiz\| Gion, Yuka\| Sawada, Keisuke\| Higashi, Morihiro\| Tokuhira, Michihide\| Tamaru, Jun-Ichi\| Sato, Yasuharu\|
キーワード	classic Hodgkin lymphoma methotrexate immunodeficiency programmed cell death-ligand 1 rheumatoid arthritis
発行日	2024-03-27
出版物タイトル	Cancers
巻	16巻
号	7号
出版者	MDPI
開始ページ	1298
ISSN	2072-6694
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 by the authors.
論文のバージョン	publisher
PubMed ID	38610976
DOI	10.3390/cancers16071298
Web of Science KeyUT	001201068000001
関連URL	isVersionOf https://doi.org/10.3390/cancers16071298

ANCA-associated vasculitis with isolated splenomegaly as the initial organ presentation

フルテキストURL	fulltext.pdf
著者	Kitamura, Wataru\| Kuratsune, Masatoshi\| Iseki, Akiko\| Kuyama, Shoichi\|
発行日	2024-03-27
出版物タイトル	Rheumatology Advances in Practice
巻	8巻
号	2号
出版者	Oxford University Press
開始ページ	rkae045
ISSN	2514-1775
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024.
論文のバージョン	publisher
PubMed ID	38618140
DOI	10.1093/rap/rkae045
Web of Science KeyUT	001201694800001
関連URL	isVersionOf https://doi.org/10.1093/rap/rkae045

Sigle Agent of Posttransplant Cyclophosphamide Without Calcineurin Inhibitor Controls Severity of Experimental Chronic GVHD

JaLCDOI	10.18926/AMO/66915
フルテキストURL	78_2_123.pdf
著者	Saeki, Kyosuke\| Fujiwara, Hideaki\| Seike, Keisuke\| Kuroi, Taiga\| Nishimori, Hisakazu\| Tanaka, Takehiro\| Matsuoka, Ken-ichi\| Fujii, Nobuharu\| Maeda, Yoshinobu\|
抄録	Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT.
キーワード	GVHD posttransplant cyclophosphamide hematopoietic cell transplantation HLA-identical
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-04
巻	78巻
号	2号
出版者	Okayama University Medical School
開始ページ	123
終了ページ	134
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38688830
Web of Science KeyUT	001229151800004

Impacts of Age and Gender on Brain Edema in a Mouse Water Intoxication Model

JaLCDOI	10.18926/AMO/66914
フルテキストURL	78_2_115.pdf
著者	Nakamura-Maruyama, Emi\| Irie, Keiichiro\| Narita, Kazuhiko\| Himi, Naoyuki\| Miyamoto, Osamu\| Nakamura, Takehiro\|
抄録	Brain edema causes abnormal fluid retention and can be fatal in severe cases. Although it develops in various diseases, most treatments for brain edema are classical. We analyzed the impacts of age and gender on the characteristics of a water intoxication model that induces pure brain edema in mice and examined the model’s usefulness for research regarding new treatments for brain edema. C57BL/6J mice received an intraperitoneal administration of 10% body weight distilled water, and we calculated the brain water content by measuring the brain-tissue weight immediately after dissection and after drying. We analyzed 8-OHdG and caspase-3 values to investigate the brain damage. We also applied this model in aquaporin 4 knockout (AQP4−) mice and compared these mice with wild-type mice. The changes in water content differed by age and gender, and the 8-OHdG and caspase-3 values differed by age. Suppression of brain edema by AQP4− was also confirmed. These results clarified the differences in the onset of brain edema by age and gender, highlighting the importance of considering the age and gender of model animals. Similar studies using genetically modified mice are also possible. Our findings indicate that this water intoxication model is effective for explorations of new brain edema treatments.
キーワード	brain edema water intoxication model age gender AQP4
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-04
巻	78巻
号	2号
出版者	Okayama University Medical School
開始ページ	115
終了ページ	122
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38688829
Web of Science KeyUT	001229151800003

The Roles of Neuropeptide Y in Respiratory Disease Pathogenesis via the Airway Immune Response

JaLCDOI	10.18926/AMO/66912
フルテキストURL	78_2_095.pdf
著者	Itano, Junko\| Kiura, Katsuyuki\| Maeda, Yoshinobu\| Miyahara, Nobuaki\|
抄録	The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases.
キーワード	neuropeptide y Y1 receptor airway immune response bronchial epithelial cells respiratory disease
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2024-04
巻	78巻
号	2号
出版者	Okayama University Medical School
開始ページ	95
終了ページ	106
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38688827
Web of Science KeyUT	001229151800001