| ID | 16369 |
| Eprint ID | 16369
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| フルテキストURL | |
| タイトル（別表記） | Studies on macrophage function in in vitro immune response Part 1. The role of macrophages in lymphocyte reaction to polyclonal B cell activator
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| 著者 |
篠原 佳年
岡山大学医学部第三内科学教室
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| 抄録 | To clarify the function of macrophages (MΦ) in lymphocyte reaction to polyclonal B cell activator (PBA), especially pokeweed mitogen (PWM) and Staphylococcal phage lysate (SPL), the pattern of PWM-induced IgG synthesis and the degree of PBA-induced DNA synthesis by unfractionated mononuclear cells (MNC) or MΦ depleted MNC fraction were examined. The response of the MΦ depleted MNC fraction to PBA was significantly higher than that of unfractionated MNC. The addition of 10% MΦ to the depleted MNC fraction enhanced both responses, but too many MΦ reduced PWM-induced IgG synthesis. These results suggest that the presence of MΦ is not necessary in PBA-induced lymphocyte reaction and that the maximal response is obtained by the addition on optimal number of MΦ. Moreover, an excessive number of MΦ suppresses the IgG synthetic response.
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| キーワード | polyclonal B cell activator
macrophage
PWM-induced Ig synthesis
(3)H-thymidine incorporation
nonspecific esterase staining
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| 発行日 | 1983-10-30
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| 出版物タイトル |
岡山医学会雑誌
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| 出版物タイトル（別表記） | Journal of Okayama Medical Association
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| 巻 | 95巻
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| 号 | 9-10号
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| 出版者 | 岡山医学会
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| 出版者（別表記） | Okayama Medical Association
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| 開始ページ | 871
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| 終了ページ | 880
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| ISSN | 0030-1558
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| NCID | AN00032489
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| 資料タイプ |
学術雑誌論文
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| オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/95/9-10/95_9-10_871/_article/-char/ja/
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| 関連URL | http://www.okayama-u.ac.jp/user/oma/index.html
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| 言語 |
日本語
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| 著作権者 | 岡山医学会
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| 論文のバージョン | publisher
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| 査読 |
有り
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| Eprints Journal Name | joma
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