リンパ節の反応性に関する研究 とくに輸出リンパ流によるリンパ球放出に及ぼす抗原刺激の影響

The effects of antigenic and non-antigenic stimulations on the cell output through the efferent lymph from the popliteal lymph nodes of adult rabbits were studied. The chief results obtained are as follows: 1. The cell output through the efferent lymph flow is greatly increased by antigenic stimulations and the magnitute of increase in the cell output runs almost parallel to that of the increase in nodal weight. 2. Heterograft causes a marked increase in the cell output from regional lymph node, whereas homograft hardly produces such an effect. 3. Complete Freund's adjuvant with Mycobacteria also increases the cell output from lymph node to a considerable extent, whereas incomplete Freund's adjuvant without Mycobacteria is less effective. 4. However, when injected with bovine gamma-globulin, incomplete Freund's adjuvant also produces a marked increase in the cell output from lymph node. 5. The increase in the cell output from lymph node produced by antigenic stimulation is defenitely accompanied by the appearance of large pyroninophilic blast cells in the efferent lymph. In contrast, complete Freund's adjuvant or incomplete Freund's adjuvant alone is not able to elicit an appearance of these cell in the efferent lymph. 6. An incresse in cell output through the efferent lymph from the regional lymph node, and the occurrence of large pyroninophilic cells in the efferent lymph, particularly the latter, are considered to be specific to antigenic stimulation. Therefore, these reactions may be used as measures to test the antigenecity of stimulating agents.