線維芽細胞抑制剤による悪性腫瘍の治療に関する研究 第2編 クロロキンの担腫瘍動物肝カタラーゼ活性に及ぼす影響について

Because catalase activity is thought an important indication in chloroquine efficiency against malignant tumors, changes of the catalase activity of the liver in the animals bearing malignant tumors was observed by chloroquine administration. 1) No significant changes were noted in the catalase activity of the liver of the normal healthy mice by administration of chloroquine diphosphate of daily dosis of 25 mg/kg. 2) It was clearly demonstrated that catalase activyit of liver tissue of the normal mice was scarcely influenced to direct addition administration of 200 γ/ml/hr of chloroquine diphosbhate. 3) In the mice beariog Bashford cancer given daily dosis of 25mg/kg of chloroquine diphosphate, lowering of liver catalase activity was observed to be considerably inhibitory in the first week and tended to show more remarkable with passage of the dates. 4) No inhibition of the decreasing liver catalase activity was observed by one week administration of chloroquine diphosphate in the mice bearing Ehrlich carcinoma. 5) Decreasing of the liver catalase activity was suppressed by one week administration of chloroquine in the rats bearing Yoshida sarcoma. 6) No inhibition of the decreasing Iiver ceatalere activity was observed by 2 weeks administration of 10 mg/kg of chloroqujne diphosphate in the rabbits bearing Brown-Pearce cancer which dimonstrated far advenced canceraus involvemeut and ascites accumulation. 7) It is clear from these data that chloroquine does not influence to the liver catalase activity of normal animals, and inhibition of decreasing liver catalase activity is observed is the animals bearing tumors which growth is inhibited by chloroquine administration.