検索結果 - 岡山大学学術成果リポジトリ

Bacterial DNA and serum IgG antibody titer assays for assessing infection of human-pathogenic and dog-pathogenic Porphyromonas species in dogs

フルテキストURL	fulltext.pdf
著者	Tai-Tokuzen, Masako\| Ito, Takashi\| Tamura, Kazuya\| Hirayama, Haruko\| Ogawa, Hirohito\| Nakamura, Shin\| Okubo, Keisuke\| Omori, Kazuhiro\| Yamamoto, Tadashi\| Mominoki, Katsumi\| Takashiba, Shogo\|
キーワード	Cross infection Human and dog Periodontal disease Porphyromonas gingivalis Porphyromonas gulae Detection assay
発行日	2024-06-15
出版物タイトル	Heliyon
巻	10巻
号	11号
出版者	Elsevier
開始ページ	e31872
ISSN	2405-8440
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 The Authors
論文のバージョン	publisher
DOI	10.1016/j.heliyon.2024.e31872
Web of Science KeyUT	001247098300003
関連URL	isVersionOf https://doi.org/10.1016/j.heliyon.2024.e31872

In Vitro Study of Tumor-Homing Peptide-Modified Magnetic Nanoparticles for Magnetic Hyperthermia

フルテキストURL	fulltext.pdf
著者	Zhou, Shengli\| Tsutsumiuchi, Kaname\| Imai, Ritsuko\| Miki, Yukiko\| Kondo, Anna\| Nakagawa, Hiroshi\| Watanabe, Kazunori\| Ohtsuki, Takashi\|
キーワード	tumor-homing peptide magnetic hyperthermia magnetic nanoparticles ferroptosis tumor-specific delivery
発行日	2024-06-03
出版物タイトル	Molecules
巻	29巻
号	11号
出版者	MDPI
開始ページ	2632
ISSN	1420-3049
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 by the authors.
論文のバージョン	publisher
PubMed ID	38893510
DOI	10.3390/molecules29112632
Web of Science KeyUT	001245732000001
関連URL	isVersionOf https://doi.org/10.3390/molecules29112632

Anti-HMGB1 mAb Therapy Reduces Epidural Hematoma Injury

フルテキストURL	fulltext.pdf
著者	Gao, Shangze\| Wang, Dengli\| Liu, Keyue\| Tomono, Yasuko\| Fu, Li\| Gao, Yuan\| Takahashi, Yohei\| Yata, Mariko\| Nishibori, Masahiro\|
キーワード	epidural hematoma HMGB1 inflammatory response
発行日	2024-05-28
出版物タイトル	International Journal of Molecular Sciences
巻	25巻
号	11号
出版者	MDPI
開始ページ	5889
ISSN	1661-6596
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 by the authors.
論文のバージョン	publisher
PubMed ID	38892076
DOI	10.3390/ijms25115889
Web of Science KeyUT	001245280300001
関連URL	isVersionOf https://doi.org/10.3390/ijms25115889

Palaeoproteomic investigation of an ancient human skeleton with abnormal deposition of dental calculus

フルテキストURL	fulltext.pdf
著者	Uchida-Fukuhara, Yoko\| Shimamura, Shigeru\| Sawafuji, Rikai\| Nishiuchi, Takumi\| Yoneda, Minoru\| Ishida, Hajime\| Matsumura, Hirofumi\| Tsutaya, Takumi\|
備考	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-55779-y\|
発行日	2024-03-11
出版物タイトル	Scientific Reports
巻	14巻
号	1号
出版者	Nature Portfolio
開始ページ	5938
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024
論文のバージョン	publisher
PubMed ID	38467689
DOI	10.1038/s41598-024-55779-y
Web of Science KeyUT	001182621300059
関連URL	isVersionOf https://doi.org/10.1038/s41598-024-55779-y

PAI-1 mediates acquired resistance to MET-targeted therapy in non-small cell lung cancer

フルテキストURL	fulltext.pdf
著者	Thu, Yin Min\| Suzawa, Ken\| Tomida, Shuta\| Ochi, Kosuke\| Tsudaka, Shimpei\| Takatsu, Fumiaki\| Date, Keiichi\| Matsuda, Naoki\| Iwata, Kazuma\| Nakata, Kentaro\| Shien, Kazuhiko\| Yamamoto, Hiromasa\| Okazaki, Mikio\| Sugimoto, Seiichiro\| Toyooka, Shinichi\|
発行日	2024-05-17
出版物タイトル	PLoS ONE
巻	19巻
号	5号
出版者	Public Library of Science
開始ページ	e0300644
ISSN	1932-6203
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 Thu et al.
論文のバージョン	publisher
PubMed ID	38758826
DOI	10.1371/journal.pone.0300644
Web of Science KeyUT	001227109100078
関連URL	isVersionOf https://doi.org/10.1371/journal.pone.0300644

Dissection of the signal transduction machinery responsible for the lysyl oxidase-like 4-mediated increase in invasive motility in triple-negative breast cancer cells: mechanistic insight into the integrin-β1-NF-κB-MMP9 axis

フルテキストURL	fulltext.pdf
著者	Jiang, Fan\| Chen, Youyi\| Tomonobu, Nahoko\| Kinoshita, Rie\| Komalasari, Ni Luh Gede Yoni\| Kasano-Camones, Carlos Ichiro\| Ninomiya, Kazumi\| Murata, Hitoshi\| Yamamoto, Ken-Ichi\| Gohara, Yuma\| Ochi, Toshiki\| Ruma, I. Made Winarsa\| Sumardika, I. Wayan\| Zhou, Jin\| Honjo, Tomoko\| Sakaguchi, Yoshihiko\| Yamauchi, Akira\| Kuribayashi, Futoshi\| Futami, Junichiro\| Kondo, Eisaku\| Inoue, Yusuke\| Toyooka, Shinichi\| Sakaguchi, Masakiyo\|
キーワード	breast cancer invasion lysyl oxidase NF-κB MMP9
発行日	2024-05-28
出版物タイトル	Frontiers in Oncology
巻	14巻
出版者	Frontiers Media
開始ページ	1371307
ISSN	2234-943X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 Jiang, Chen, Tomonobu, Kinoshita, Komalasari, Kasano-Camones, Ninomiya, Murata, Yamamoto, Gohara, Ochi, Ruma, Sumardika, Zhou, Honjo, Sakaguchi, Yamauchi, Kuribayashi, Futami, Kondo, Inoue, Toyooka and Sakaguchi.
論文のバージョン	publisher
PubMed ID	38863623
DOI	10.3389/fonc.2024.1371307
Web of Science KeyUT	001242409800001
関連URL	isVersionOf https://doi.org/10.3389/fonc.2024.1371307

Circadian Rhythms Fluctuate the Treatment Effects of Intravesical Treatments on Rat Urinary Frequency Models

フルテキストURL	fulltext.pdf
著者	Watanabe, Tomofumi\| Sadahira, Takuya\| Tominaga, Yusuke\| Maruyama, Yuki\| Nagasaki, Naoya\| Sekito, Takanori\| Edamura, Kohei\| Watanabe, Toyohiko\| Araki, Motoo\| Watanabe, Masami\|
発行日	2024-05-28
出版物タイトル	Veterinary Medicine International
巻	2024巻
出版者	Hindawi
開始ページ	6505595
ISSN	2090-8113
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	©2024 Tomofumi Watanabe et al.
論文のバージョン	publisher
PubMed ID	38836165
DOI	10.1155/2024/6505595
Web of Science KeyUT	001242506200002
関連URL	isVersionOf https://doi.org/10.1155/2024/6505595

SPRED2 Is a Novel Regulator of Autophagy in Hepatocellular Carcinoma Cells and Normal Hepatocytes

フルテキストURL	fulltext.pdf
著者	Wang, Tianyi\| Gao, Tong\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Sakaguchi, Masakiyo\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
キーワード	autophagy mitophagy SPRED proteins MAPK/ERK mTOR hepatocellular carcinoma
発行日	2024-06-06
出版物タイトル	International Journal of Molecular Sciences
巻	25巻
号	11号
出版者	MDPI
開始ページ	6269
ISSN	1661-6596
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	©2024 by the authors.
論文のバージョン	publisher
DOI	10.3390/ijms25116269
Web of Science KeyUT	001245555700001
関連URL	isVersionOf https://doi.org/10.3390/ijms25116269

Realization of nodal-ring semimetal in pressurized black phosphorus

フルテキストURL	fulltext.pdf
著者	Akiba, Kazuto\| Akahama, Yuichi\| Tokunaga, Masashi\| Kobayashi, Tatsuo C.\|
発行日	2024-05-03
出版物タイトル	Physical Review B
巻	109巻
号	20号
出版者	American Physical Society (APS)
開始ページ	L201103
ISSN	2469-9950
NCID	AA11187113
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	©2024 American Physical Society
論文のバージョン	publisher
DOI	10.1103/physrevb.109.l201103
Web of Science KeyUT	001238896400003
関連URL	isVersionOf https://doi.org/10.1103/physrevb.109.l201103

Switchable synthesis of 3-aminoindolines and 2′-aminoarylacetic acids using Grignard reagents and 3-azido-2-hydroxyindolines

フルテキストURL	fulltext20240618-01.pdf
著者	Yamashiro, Toshiki\| Abe, Takumi\|
備考	This is an accepted manuscript published by The Royal Society of Chemistry.\| This fulltext file will be available in May 2025.\|
発行日	2024
出版物タイトル	Chemical Communications
巻	60巻
号	52号
出版者	Royal Society of Chemistry (RSC)
開始ページ	6615
終了ページ	6618
ISSN	1359-7345
NCID	AA11071130
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Royal Society of Chemistry 2024
論文のバージョン	author
PubMed ID	38847113
DOI	10.1039/d4cc01448k
Web of Science KeyUT	001240225400001
関連URL	isVersionOf https://doi.org/10.1039/d4cc01448k

An NLR paralog Pit2 generated from tandem duplication of Pit1 fine-tunes Pit1 localization and function

フルテキストURL	fulltext.pdf
著者	Li, Yuying\| Wang, Qiong\| Jia, Huimin\| Ishikawa, Kazuya\| Kosami, Ken-Ichi\| Ueba, Takahiro\| Tsujimoto, Atsumi\| Yamanaka, Miki\| Yabumoto, Yasuyuki\| Miki, Daisuke\| Sasaki, Eriko\| Fukao, Yoichiro\| Fujiwara, Masayuki\| Kaneko-Kawano, Takako\| Tan, Li\| Kojima, Chojiro\| Wing, Rod A.\| Sebastian, Alfino\| Nishimura, Hideki\| Fukada, Fumi\| Niu, Qingfeng\| Shimizu, Motoki\| Yoshida, Kentaro\| Terauchi, Ryohei\| Shimamoto, Ko\| Kawano, Yoji\|
備考	The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-024-48943-5\|
発行日	2024-05-30
出版物タイトル	Nature Communications
巻	15巻
号	1号
出版者	Nature Portfolio
開始ページ	4610
ISSN	2041-1723
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024
論文のバージョン	publisher
PubMed ID	38816417
DOI	10.1038/s41467-024-48943-5
Web of Science KeyUT	001236316700012
関連URL	isVersionOf https://doi.org/10.1038/s41467-024-48943-5

Absolute lymphocyte count and neutrophil-to-lymphocyte ratio as predictors of CDK 4/6 inhibitor efficacy in advanced breast cancer

フルテキストURL	fulltext.pdf
著者	Nakamoto, Shogo\| Shien, Tadahiko\| Iwamoto, Takayuki\| Kubo, Shinichiro\| Yamamoto, Mari\| Yamashita, Tetsumasa\| Kuwahara, Chihiro\| Ikeda, Masahiko\|
発行日	2024-04-30
出版物タイトル	Scientific Reports
巻	14巻
号	1号
出版者	Nature Portfolio
開始ページ	9869
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024
論文のバージョン	publisher
PubMed ID	38684839
DOI	10.1038/s41598-024-60101-x
Web of Science KeyUT	001211286800006
関連URL	isVersionOf https://doi.org/10.1038/s41598-024-60101-x

Photoinduced dynamics during electronic transfer from narrow to wide bandgap layers in one-dimensional heterostructured materials

フルテキストURL	fulltext.pdf
著者	Saida, Yuri\| Gauthier, Thomas\| Suzuki, Hiroo\| Ohmura, Satoshi\| Shikata, Ryo\| Iwasaki, Yui\| Noyama, Godai\| Kishibuchi, Misaki\| Tanaka, Yuichiro\| Yajima, Wataru\| Godin, Nicolas\| Privault, Gael\| Tokunaga, Tomoharu\| Ono, Shota\| Koshihara, Shin-Ya\| Tsuruta, Kenji\| Hayashi, Yasuhiko\| Bertoni, Roman\| Hada, Masaki\|
備考	The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-024-48880-3\|
発行日	2024-05-30
出版物タイトル	Nature Communications
巻	15巻
号	1号
出版者	Nature Portfolio
開始ページ	4600
ISSN	2041-1723
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024
論文のバージョン	publisher
PubMed ID	38816382
DOI	10.1038/s41467-024-48880-3
Web of Science KeyUT	001236316700036
関連URL	isVersionOf https://doi.org/10.1038/s41467-024-48880-3

Palliative Gamma Knife Radiosurgery for a Small Part of a Large Vestibular Schwannoma in an Elderly Patient

JaLCDOI	10.18926/AMO/67207
フルテキストURL	78_3_301.pdf
著者	Nakazaki, Kiyoshi\| Hirai, Satoshi\| Hishikawa, Tomohito\|
抄録	We report a case of a large vestibular schwannoma in an 80-year-old female patient that shrank after palliative Gamma Knife radiosurgery (GKS). Neurological symptoms included hearing deterioration and facial palsy. The tumor volume was 21.9 mL. Craniotomy was considered high-risk, and conventional GKS was risky, owing to the risk of transient enlargement. Therefore, GKS was performed on only a portion of the tumor. The marginal dose (12 Gy) volume was 3.8 mL (17.4%). The tumor began to shrink after transient enlargement. Sixty months later, the tumor volume was only 3.1 mL, and the patient was able to maintain independent activities of daily living without salvage treatment.
キーワード	vestibular schwannoma Gamma Knife radiosurgery large volume palliative elderly patient
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2024-06
巻	78巻
号	3号
出版者	Okayama University Medical School
開始ページ	301
終了ページ	306
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38902220
Web of Science KeyUT	001267340600001

Calcification of a Hydrophilic Acrylic Intraocular Lens after Glaucoma Surgery

JaLCDOI	10.18926/AMO/67206
フルテキストURL	78_3_295.pdf
著者	Okamoto, Sara\| Shiode, Yusuke\| Kimura, Shuhei\| Hosokawa, Mio\| Matoba, Ryo\| Kanzaki, Yuki\| Kindo, Hiroya\| Morita, Tetsuro\| Tsuji, Akihiro\| Takahashi, Kosuke\| Morizane, Yuki\|
抄録	A Japanese woman in her 70s was referred to our hospital for the evaluation and treatment of high intraocular pressure (IOP) in her right eye. She had undergone bilateral cataract surgeries and the insertion of hydrophilic acrylic intraocular lenses (IOLs). We performed trabeculotomy and trabeculectomy to lower her right IOP; thereafter, a circular opacity was observed on the right eye’s IOL surface. We removed the right IOL because that eye’s vision had decreased due to IOL opacification. The analysis of the removed IOL revealed that the main opacity component was calcium phosphate. This is the first post-glaucoma-surgery IOL calcification case report.
キーワード	intraocular lens IOL IOL calcification hydrophilic acrylic IOL glaucoma surgery
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2024-06
巻	78巻
号	3号
出版者	Okayama University Medical School
開始ページ	295
終了ページ	300
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38902219
Web of Science KeyUT	001267339400001

A Case of Gallbladder Metastasis of Malignant Melanoma

JaLCDOI	10.18926/AMO/67205
フルテキストURL	78_3_291.pdf
著者	Minagi, Hitoshi\| Aoki, Hideki\| Doita, Susumu\| Miyake, Eiki\| Ogawa, Toshihiro\| Taniguchi, Fumitaka\| Watanabe, Megumi\| Arata, Takashi\| Katsuda, Koh\| Tanakaya, Kohji\|
抄録	In the clinical course of malignant melanoma, which can metastasize to multiple organs, gallbladder metastases are rarely detected. A 69-year-old man who underwent resection of a primary malignant melanoma was subsequently treated with nivolumab for lung metastases and achieved complete response. Seven years after surgery, multiple nodules were found in the gallbladder, and he underwent laparoscopic cholecystectomy. The postoperative diagnosis was metastases of malignant melanoma. He has been recurrence-free 8 months after surgery. If radical resection is possible, such surgery should be performed for gallbladder metastases found in patients with other controlled lesions of malignant melanoma.
キーワード	malignant melanoma gallbladder metastasis laparoscopic cholecystectomy
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2024-06
巻	78巻
号	3号
出版者	Okayama University Medical School
開始ページ	291
終了ページ	294
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38902218
Web of Science KeyUT	001267351900003

Organized Chronic Subdural Hematoma (OCSDH) Mimicking Meningioma

JaLCDOI	10.18926/AMO/67204
フルテキストURL	78_3_285.pdf
著者	Hirano, Shuichiro\| Otani, Yoshihiro\| Fujii, Kentaro\| Date, Isao\|
抄録	Organized chronic subdural hematoma (OCSDH) is a relatively rare condition that forms over a longer period of time compared to chronic subdural hematoma and is sometimes difficult to diagnose with preoperative imaging. We resected an intracranial lesion in a 37-year-old Japanese man; the lesion had been increasing in size for >17 years. The preoperative diagnosis based on imaging findings was meningioma; however, pathological findings revealed OCSDH. Clinicians should be aware that OCSDH mimics other tumors and consider surgical strategies for this disease.
キーワード	meningioma organized chronic subdural hematoma
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2024-06
巻	78巻
号	3号
出版者	Okayama University Medical School
開始ページ	285
終了ページ	290
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38902217
Web of Science KeyUT	001267351900002

Spontaneous Bilateral Pneumothorax in a Patient with Anorexia Nervosa: The Management of Prolonged Postoperative Air Leakage

JaLCDOI	10.18926/AMO/67203
フルテキストURL	78_3_281.pdf
著者	Okada, Kazuhiro\| Maki, Yuho\| Matsubara, Kei\| Hirano, Yutaka\| Fujiwara, Toshiya\| Matsuura, Motoki\|
抄録	A 24-year-old Japanese female with anorexia nervosa presented to our hospital for bilateral pneumothorax, and 12-Fr thoracostomy catheters were inserted into the bilateral pleural cavities. On hospital day 9, a thoracoscopic bullectomy was performed. However, air leakage relapsed on both sides on postoperative day 1. The air leakage on the right side was particularly persistent, and we switched the drainage to a Heimlich valve. Both lungs expanded gradually and the chest tube was removed on postoperative day 19. Passive pleural drainage might be an option for prolonged air leakage after a bullectomy in patients with anorexia nervosa.
キーワード	spontaneous pneumothorax anorexia nervosa Heimlich valve
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2024-06
巻	78巻
号	3号
出版者	Okayama University Medical School
開始ページ	281
終了ページ	284
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38902216
Web of Science KeyUT	001267351900001

Effect of Humidified High-Flow Nasal Cannula Oxygen Therapy with a Pulmonary Infection Control Window as a Ventilation Switching Indication in Combination with Atomizing Inhalation of Terbutaline on the Lung Function of Patients with Acute Exacerbation of COPD

JaLCDOI	10.18926/AMO/67202
フルテキストURL	78_3_271.pdf
著者	Ye, Mengjiao\| Zhang, Renwei\|
抄録	We investigated how humidified high-flow nasal cannula oxygen therapy (HFNC) with a pulmonary infection control (PIC) window as a ventilation switching indication in combination with atomizing inhalation of terbutaline affects the lung function of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). We examined 140 hospitalized AECOPD patients randomized to control and observation groups. Conventional supportive therapy and invasive mechanical ventilation with tracheal intubation were conducted in both groups, with a PIC window as the indication for ventilation switching. Noninvasive positive pressure ventilation (NIPPV) plus atomizing inhalation of terbutaline was used in the control group. In the observation group, HFNC combined with atomizing inhalation of terbutaline was used. Compared to the control group, after 48-hr treatment and treatment completion, the observation group had significantly increased levels of lung function indicators (maximal voluntary ventilation [MVV] plus forced vital capacity [FVC], p<0.05) and oxygen metabolism indicators (arterial oxygen partial pressure [PaO2], arterial oxygen content [CaO2], and oxygenation index, p<0.05). The comparison of the groups revealed that the levels of airway remodeling indicators (matrix metalloproteinase-2 [MMP-2], tissue inhibitor of metalloproteinase 2 [TIMP-2] plus MMP-9) and inflammatory indicators (interferon gamma [IFN-γ] together with interleukin-17 [IL-17], IL-10 and IL-4) were significantly lower after 48 h of treatment as well as after treatment completion (both p<0.05). These results demonstrate that HFNC with a PIC window as the indication for ventilation switching combined with atomizing inhalation of terbutaline can relieve the disorder of oxygen metabolism and correct airway hyper-reactivity.
キーワード	chronic obstructive pulmonary disease inhalation oxygen therapy pulmonary function ventilation
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-06
巻	78巻
号	3号
出版者	Okayama University Medical School
開始ページ	271
終了ページ	279
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38902215
Web of Science KeyUT	001267351000008

The Role of the Lipid Profile and Oxidative Stress in Fatigue, Sleep Disorders and Cognitive Impairment in Patients with Multiple Sclerosis

JaLCDOI	10.18926/AMO/67201
フルテキストURL	78_3_259.pdf
著者	Vural, Gonul\| Demir, Esra\| Gumusyayla, Sadiye\| Eren, Funda\| Barakli, Serdar\| Neselioglu, Salim\| Erel, Ozcan\|
抄録	The aim of this study is to investigate the relationship of the lipid profile, dysfunctional high-density lipoprotein, ischaemia-modified albumin and thiol–disulfide homeostasis with cognitive impairment, fatigue and sleep disorders in patients with multiple sclerosis. The cognitive functions of patients were evaluated with the Brief International Cognitive Assessment for Multiple Sclerosis battery. Fatigue was evaluated with the Fatigue Severity Scale and the Fatigue Impact Scale. The Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale were used to assess patients’ sleep disturbance. Peripheral blood samples were collected, and lipid levels and myeloperoxidase and paraoxonase activity were measured. The myeloperoxidase/paraoxonase ratio, which indicates dysfunctional high-density lipoprotein, was calculated. Thiol–disulfide homeostasis and ischaemia-modified albumin were measured. We did not identify any relationship between dysfunctional high-density lipoprotein and the physical disability, cognitive decline, fatigue and sleep problems of multiple sclerosis. Thiol–disulfide homeostasis was associated with cognitive scores. The shift of the balance towards disulfide was accompanied by a decrease in cognitive scores. On the other hand, we did not detect any relationship between fatigue and sleep disorders and thiol–disulfide homeostasis. Our findings revealed a possible correlation between cognitive dysfunction and thiol–disulfide homeostasis in multiple sclerosis patients.
キーワード	multiple sclerosis dysfunctional HDL thiol–disulfide homeostasis cognitive decline
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-06
巻	78巻
号	3号
出版者	Okayama University Medical School
開始ページ	259
終了ページ	270
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38902214
Web of Science KeyUT	001267351000007