高令者白血病に関する研究 第2編 高令者白血病の予後因子に関する検討

The prognostic factors in acute myelocytic leukemia (AML) in the old were evaluated in order to examine its optimal treatment. Items studied in the present paper were sex, age, fever, organomegaly, peripheral white blood cell counts, percentage of leukemic cells in peripheral blood and bone marrow, platelet counts, the presence of Auer bodies and combination chemotherapy and its clinical efficacy. In typical AML in the old, prolongation of survival was recognized in patients treated with a systemic combination chemotherapy, and fever was thought to be a sign of an unfavorable prognosis. On the other hand, clinical efficacy of the systemic combination chemotherapy was not recognized in hypoplastic AML in the old. Organomegaly was determined to be a sign of an unfavorable prognosis. These results suggested that the optimal treatment schedule should be established on the basis of not only the bone marrow status but also the prognostic factors presented here.