start-ver=1.4 cd-journal=joma no-vol=43 cd-vols= no-issue=6 article-no= start-page=1108 end-page=1116 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250412 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Spray-drying of polymer solutions across a broad concentration range and the subsequent formation of a few micro- ?nano-meter sized fibers en-subtitle= kn-subtitle= en-abstract= kn-abstract=Spray drying is a widely utilized technique for the concentration and fine particulation of dried products. This study demonstrated that a versatile spray dryer, equipped with a two-fluid nozzle atomizer, can convert polymer solutions into nanoscale fibers by manipulating the conditions of the polymer solutions. The polymers employed in this research included polyvinylpyrrolidones (Mw 24.5 k to 60?kDa), dextrans (70 k to 450?650?kDa), pullulan, gum Arabic, Eudragit and agar, with methanol and water serving as solvents. Various combinations of polymers and solvents were subjected to spray drying at polymer concentrations ranging from 5 to 1000?g/L. Scanning electron microscopy analyses of the spray-dried samples indicated that the products transitioned from micrometer-sized particles to sub-micrometer fibers in several instances when the polymer concentrations exceeded specific threshold levels. The investigation also explored the relationship between these threshold concentrations and the surface tension and viscosity of the polymer solutions. en-copyright= kn-copyright= en-aut-name=AragaChika en-aut-sei=Araga en-aut-mei=Chika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FukushimaKaito en-aut-sei=Fukushima en-aut-mei=Kaito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SatoHaruna en-aut-sei=Sato en-aut-mei=Haruna kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HondaNao en-aut-sei=Honda en-aut-mei=Nao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HasegawaTakato en-aut-sei=Hasegawa en-aut-mei=Takato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakasoKoichi en-aut-sei=Nakaso en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IshidaNaoyuki en-aut-sei=Ishida en-aut-mei=Naoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ImamuraKoreyoshi en-aut-sei=Imamura en-aut-mei=Koreyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=6 en-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=7 en-affil=Department of Chemical Engineering and Material Sciences, Faculty of Science and Engineering, Doshisha University kn-affil= affil-num=8 en-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=Sub-micron fiber kn-keyword=Sub-micron fiber en-keyword=spray-drying kn-keyword=spray-drying en-keyword=two fluid nozzle atomizer kn-keyword=two fluid nozzle atomizer en-keyword=polyvinylpyrrolidone kn-keyword=polyvinylpyrrolidone en-keyword=polysaccharide kn-keyword=polysaccharide END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=3 article-no= start-page=343 end-page=350 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Characteristics of Early Gastric Cancer in a Patient with a History of Helicobacter pylori Infection and No History of Eradication Therapy en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective The characteristics of gastric cancer in patients with atrophic mucosa and no apparent history of Helicobacter pylori eradication have not been thoroughly investigated. Therefore, this study examined the clinicopathological characteristics of gastric cancer in these patients.
Methods We retrospectively examined the endoscopic and pathological characteristics of gastric cancer in patients who underwent endoscopic submucosal dissection.
Patients We divided the patients into 2 groups: those with gastric atrophy and no history of eradication (group A; n=102) and those with a history of eradication (group B; n=161). In group A, patients were further divided into mild atrophy (group C) and severe atrophy (group D) groups, while group B was further divided into those who underwent eradication treatment >5 years ago (group E) and those who underwent eradication 1-5 years ago (group F).
Results Group A comprised significantly older individuals (75}8.0 vs. 71}7.5 years old, p<0.001) with a higher frequency of elevated gastric cancer than group B (32.4% vs. 17.4%, p=0.006). Compared with group E, group A was older and had a greater incidence of elevated gastric cancer. The incidence of gastric cancer in the U or M region was lower in group C than in group D.
Conclusion Gastric cancer in patients with gastric atrophy and no history of eradication was associated with an older age and higher frequency of elevated-type morphology than in those with a history of eradication. en-copyright= kn-copyright= en-aut-name=KuraokaSakiko en-aut-sei=Kuraoka en-aut-mei=Sakiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InoShoko en-aut-sei=Ino en-aut-mei=Shoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SatomiTakuya en-aut-sei=Satomi en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HamadaKenta en-aut-sei=Hamada en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KonoYoshiyasu en-aut-sei=Kono en-aut-mei=Yoshiyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KawaharaYoshiro en-aut-sei=Kawahara en-aut-mei=Yoshiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=OtsukaMotoyuki en-aut-sei=Otsuka en-aut-mei=Motoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Practical Gastrointestinal Endoscopy, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Practical Gastrointestinal Endoscopy, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=autoimmune gastritis kn-keyword=autoimmune gastritis en-keyword=eradication kn-keyword=eradication en-keyword=gastric cancer kn-keyword=gastric cancer en-keyword=Helicobacter pylori kn-keyword=Helicobacter pylori END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=1 article-no= start-page=19 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250419 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Quantitative assessment of adhesive effects on partial and full compressive strength of LVL in the edge-wise direction en-subtitle= kn-subtitle= en-abstract= kn-abstract=Laminated wood-based materials have been widely developed, and the laminating process and adhesive itself have been reported to enhance performance beyond the sum of the individual layers' performance. This phenomenon is particularly notable under loads applied in the "edge-wise direction", where each layer bears stress collectively. These combined effects are referred to as the "adhesive effect". Strength under partial compressive loads is critical in timber engineering, as partial compressive stress generates complex stress distributions influenced by boundary conditions. The adhesive effect may also be impacted by these conditions. The aim of this study was to quantitatively and directly evaluate the adhesive effect under partial and full compressive loads using various parameters. The strength of laminated veneer lumber (LVL) with adhesive was compared to that of simply layered veneers without adhesive to assess the adhesive effect. Three mechanisms contributing to the adhesive effect were proposed: Mechanism I, caused by the deformation of the adhesive layer independently from the veneers; Mechanism II, resulting from the adhesive impregnating the veneers; and Mechanism III, arising from the reinforcement provided by adjacent veneers. The results suggested the following: (i) Mechanism I had minimal impact, as the fiber direction and the presence of additional length showed strong and slight effects on the adhesive effect, respectively; (ii) Mechanism II contributed to preventing crack propagation and altering the relationships among mechanical properties, with its effectiveness increasing as the adhesive weight increased; and (iii) Mechanism III functioned as a crossband effect, reinforcing weaknesses caused by the slope of the grain and the angle of the annual rings. en-copyright= kn-copyright= en-aut-name=SudoRyutaro en-aut-sei=Sudo en-aut-mei=Ryutaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyamotoKohta en-aut-sei=Miyamoto en-aut-mei=Kohta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IdoHirofumi en-aut-sei=Ido en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Okayama University, Graduate School of Environmental, Life, Natural Science and Technology kn-affil= affil-num=2 en-affil=Forestry and Forest Products Research Institute kn-affil= affil-num=3 en-affil=Forestry and Forest Products Research Institute kn-affil= en-keyword=Laminated veneer lumber (LVL) kn-keyword=Laminated veneer lumber (LVL) en-keyword=Partial compressive load kn-keyword=Partial compressive load en-keyword=Bearing strength kn-keyword=Bearing strength en-keyword=Embedment strength kn-keyword=Embedment strength en-keyword=Partial compression perpendicular to grain (PCPG) kn-keyword=Partial compression perpendicular to grain (PCPG) en-keyword=Adhesive layer kn-keyword=Adhesive layer END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=4 article-no= start-page=e70151 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250416 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Frequency and Characteristics of Gastrointestinal Diseases in Patients With Neurofibromatosis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background and Aim: Patients with neurofibromatosis (NF) frequently experience gastrointestinal symptoms, but the specific characteristics of these lesions are not well understood.
Methods: To investigate the prevalence and nature of gastrointestinal diseases in this population, we analyzed the gastrointestinal lesions identified through endoscopic examinations in patients with NF.
Results: We included 225 patients with NF type 1 (NF1) and 15 with NF type 2 (NF2). None of the NF2 patients underwent endoscopy. Among the NF1 patients, 27 received endoscopies, and 13 (59%) had gastrointestinal lesions. These 13 patients were predominantly male (10 males and three females), with a median age of 53 years (range: 19-76 years). The identified lesions included colorectal polyps (n = 6), gastrointestinal stromal tumors ([GIST], n = 4), subepithelial lesions (n = 3), gastric fundic gland polyps (n = 3), diffuse intestinal ganglioneuromatosis (n = 2), esophageal polyps (n = 2), a Schwann cell hamartoma (n = 1), esophageal cancer (n = 1), and a gastric hyperplastic polyp (n = 1). All GISTs and one case of diffuse intestinal ganglioneuromatosis were surgically resected. Interestingly, six out of 13 patients were asymptomatic. Additionally, all patients who required surgery were 40 years of age or older.
Conclusions: These findings suggest that routine endoscopic examinations, along with imaging techniques like computed tomography and magnetic resonance imaging, could be beneficial for the early detection of gastrointestinal lesions in NF1 patients aged 40 and above. en-copyright= kn-copyright= en-aut-name=HondaManami en-aut-sei=Honda en-aut-mei=Manami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamasakiYasushi en-aut-sei=Yamasaki en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HiraokaSakiko en-aut-sei=Hiraoka en-aut-mei=Sakiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KawaharaYoshiro en-aut-sei=Kawahara en-aut-mei=Yoshiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OtsukaMotoyuki en-aut-sei=Otsuka en-aut-mei=Motoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Practical Gastrointestinal Endoscopy,Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=colonoscopy kn-keyword=colonoscopy en-keyword=esophagogastroduodenoscopy kn-keyword=esophagogastroduodenoscopy en-keyword=gastrointestinal neoplasms kn-keyword=gastrointestinal neoplasms en-keyword=gastrointestinal stromal tumor kn-keyword=gastrointestinal stromal tumor en-keyword=neurofibromatosis kn-keyword=neurofibromatosis END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250321 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=’Ó‡‰ª‘åˆâÕ 23 \‘æ37ŽŸ’²¸\iˆÙ•ª–ìŠî‘b‰ÈŠwŒ¤‹†ŠV‰c‚É”º‚¤”­Œ@’²¸j en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=–Ø‘º— kn-aut-sei=–Ø‘º kn-aut-mei=— aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ŽRŒû—YŽ¡ kn-aut-sei=ŽRŒû kn-aut-mei=—YŽ¡ aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰F“c’ÓO˜N kn-aut-sei=‰F“c’à kn-aut-mei=“O˜N aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=“cú±”Ž”V kn-aut-sei=“cú± kn-aut-mei=”Ž”V aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=“ß{_˜Y kn-aut-sei=“ß{ kn-aut-mei=_˜Y aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=”’΃ kn-aut-sei=”’Î kn-aut-mei=ƒ aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw•¶–¾“®‘ÔŠwŒ¤‹†Š affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw•¶–¾“®‘ÔŠwŒ¤‹†Š affil-num=3 en-affil= kn-affil=‹{è‘åŠw affil-num=4 en-affil= kn-affil=ˆ¤•Q‘åŠw–¼—_‹³Žö affil-num=5 en-affil= kn-affil=‰ªŽR—‰È‘åŠw affil-num=6 en-affil= kn-affil=Œ³‰ªŽR—‰È‘åŠw END start-ver=1.4 cd-journal=joma no-vol=2023 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250220 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Bulletin of Cultural Heritage Management Division Research Institute for the Dynamics of Civilizations Okayama University 2023 kn-title=‰ªŽR‘åŠw•¶–¾“®‘ÔŠwŒ¤‹†Š•¶‰»ˆâŽYƒ}ƒlƒWƒƒ“ƒg•”–å‹I—v2023 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ŽÄ“c—º kn-aut-sei=ŽÄ“c kn-aut-mei=—º aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ƒpƒŒƒIEƒ‰ƒ{AMS”N‘㑪’èƒOƒ‹[ƒv kn-aut-sei=ƒpƒŒƒIEƒ‰ƒ{AMS”N‘㑪’èƒOƒ‹[ƒv kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=–Ø‘º— kn-aut-sei=–Ø‘º kn-aut-mei=— aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=–ìú±‹M”Ž kn-aut-sei=–ìú± kn-aut-mei=‹M”Ž aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ŽRŒû—YŽ¡ kn-aut-sei=ŽRŒû kn-aut-mei=—YŽ¡ aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Šâú±Žu•Û kn-aut-sei=Šâú± kn-aut-mei=Žu•Û aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw•¶–¾“®‘ÔŠwŒ¤‹†Š•¶‰»ˆâŽYƒ}ƒlƒWƒƒ“ƒg•”–å affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠw•¶–¾“®‘ÔŠwŒ¤‹†Š•¶‰»ˆâŽYƒ}ƒlƒWƒƒ“ƒg•”–å affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠw•¶–¾“®‘ÔŠwŒ¤‹†Š•¶‰»ˆâŽYƒ}ƒlƒWƒƒ“ƒg•”–å affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠw•¶–¾“®‘ÔŠwŒ¤‹†Š•¶‰»ˆâŽYƒ}ƒlƒWƒƒ“ƒg•”–å affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠw•¶–¾“®‘ÔŠwŒ¤‹†Š•¶‰»ˆâŽYƒ}ƒlƒWƒƒ“ƒg•”–å END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=12633 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250412 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Association of emergency intensive care unit occupancy due to brain-dead organ donors with ambulance diversion en-subtitle= kn-subtitle= en-abstract= kn-abstract=Our study aims to explore how intensive care unit (ICU) occupancy by brain-dead organ donors affects emergency ambulance diversions. In this retrospective, single-center study at an emergency ICU (EICU), brain-dead organ donors were managed until organ procurement. We classified each day between August 1, 2021, and July 31, 2023, as either an exposure day (any day with a brain-dead organ donor in the EICU from admission to organ procurement) or a control day (all other days). The study compared these days and used multiple logistic regression analysis to assess the impact of EICU occupancy by brain-dead organ donors on ambulance diversions. Over two years, 6,058 emergency patients were transported by ambulance, with 1327 admitted to the EICU, including 13 brain-dead organ donors. Brain-dead donors had longer EICU stays (17 vs. 2 days, P < 0.001). With 168 exposure and 562 control days, EICU occupancy was higher on exposure days (75% vs. 67%, P = 0.003), leading to more ambulance diversions. Logistic regression showed exposure days significantly increased ambulance diversions, with an odds ratio of 1.79 (95% CIs 1.10-2.88). This study shows that managing brain-dead organ donors in the EICU leads to longer stays and higher occupancy, resulting in more frequent ambulance diversions. These findings highlight the critical need for policies that optimize ICU resource allocation while maintaining the infrastructure necessary to support organ donation programs and ensuring continued care for brain-dead donors, who play an essential role in addressing the organ shortage crisis. en-copyright= kn-copyright= en-aut-name=YumotoTetsuya en-aut-sei=Yumoto en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ObaraTakafumi en-aut-sei=Obara en-aut-mei=Takafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HongoTakashi en-aut-sei=Hongo en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NojimaTsuyoshi en-aut-sei=Nojima en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TsukaharaKohei en-aut-sei=Tsukahara en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HisamuraMasaki en-aut-sei=Hisamura en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakaoAtsunori en-aut-sei=Nakao en-aut-mei=Atsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NaitoHiromichi en-aut-sei=Naito en-aut-mei=Hiromichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Ambulance diversion kn-keyword=Ambulance diversion en-keyword=Bed occupancy kn-keyword=Bed occupancy en-keyword=Brain death kn-keyword=Brain death en-keyword=Emergency medical services kn-keyword=Emergency medical services en-keyword=Intensive care units kn-keyword=Intensive care units en-keyword=Organ donation kn-keyword=Organ donation END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=1 article-no= start-page=124 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250407 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Surgical protocol of robotic liver resection using a two-surgeon technique (TAKUMI-3): a technical note and initial outcomes en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background Internationally, evidence supporting robotic liver resection (RLR) has gradually increased in recent years. However, a standardized protocol for RLR remains lacking. This study describes a surgical protocol and the initial outcomes of RLR in a high-volume center for robotic hepatopancreatobiliary surgery in Japan.
Methods Patients were placed in the reverse Trendelenburg position, with a supine position for anterolateral tumors and left lateral position for posterosuperior tumors. Our standard RLR protocol involved a two-surgeon technique. Liver parenchymal transection was performed by an assistant using the clamp crush technique with a console, with or without a laparoscopic Cavitron ultrasonic surgical aspirator (CUSA). Surgical techniques, including the tips, tricks, and pitfalls of RLR, are also demonstrated.
Results We performed 113 RLR at our institution for common primary diseases, including hepatocellular carcinoma (n = 52, 46.0%) and metastatic tumors (n = 48, 42.5%) between July 2022 and December 2024. The median operative time and estimated blood loss were 156 min (interquartile range [IQR], 121-209 min) and 20 mL (IQR, 0-100 mL), respectively. During liver parenchymal transection, a laparoscopic CUSA was used in 59 patients (52.2%), and a water-jet scalpel was used in 12 patients (10.6%). The incidence of mortality, major complications, and bile leakage was 0%, 6.2%, and 2.7%, respectively. The median hospital stay was 7 days (IQR, 6-9 days).
Conclusions We successfully introduced an RLR program using the two-surgeon technique. Safe implementation of RLR can be achieved upon completion of the training program and thorough understanding of the surgical protocols. en-copyright= kn-copyright= en-aut-name=TakagiKosei en-aut-sei=Takagi en-aut-mei=Kosei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujiTomokazu en-aut-sei=Fuji en-aut-mei=Tomokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YasuiKazuya en-aut-sei=Yasui en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UmedaYuzo en-aut-sei=Umeda en-aut-mei=Yuzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamadaMotohiko en-aut-sei=Yamada en-aut-mei=Motohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NishiyamaTakeyoshi en-aut-sei=Nishiyama en-aut-mei=Takeyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NagaiYasuo en-aut-sei=Nagai en-aut-mei=Yasuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KanehiraNoriyuki en-aut-sei=Kanehira en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Gastroenterological Surgery, Dentistry, and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=2 en-affil=Department of Gastroenterological Surgery, Dentistry, and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=3 en-affil=Department of Gastroenterological Surgery, Dentistry, and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=4 en-affil=Department of Hepatobiliary Pancreatic Surgery, Ehime University Graduate School of Medicine kn-affil= affil-num=5 en-affil=Department of Gastroenterological Surgery, Dentistry, and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=6 en-affil=Department of Gastroenterological Surgery, Dentistry, and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=7 en-affil=Department of Gastroenterological Surgery, Dentistry, and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=8 en-affil=Department of Gastroenterological Surgery, Dentistry, and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=9 en-affil=Department of Gastroenterological Surgery, Dentistry, and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= en-keyword=Liver resection kn-keyword=Liver resection en-keyword=Robotic surgery kn-keyword=Robotic surgery en-keyword=Training kn-keyword=Training en-keyword=Outcomes kn-keyword=Outcomes END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue=2 article-no= start-page=131 end-page=136 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effect of calcium supplementation on bone deformity and histopathological findings of skin papules in a pediatric patient with vitamin D?dependent rickets type 2A: A case report en-subtitle= kn-subtitle= en-abstract= kn-abstract=Vitamin D?dependent rickets type 2A (VDDR2A) is an autosomal recessive disease caused by pathogenic variants of the vitamin D receptor (VDR) gene. VDDR2A rickets are usually resistant to native or active vitamin D treatment because of impaired active calcium absorption against the calcium concentration gradient, which is a ligand-dependent VDR action in the small intestine. Alopecia due to an impaired skin follicular cycle is occasionally observed in patients with VDDR2A. Among the pathogenic VDR variants, most in the DNA-binding domain and some in the ligand-binding domain, which affect the dimerization of VDR with the retinoic X receptor, are associated with alopecia. Herein, we report a case of VDDR2A caused by compound heterozygous pathogenic variants of the DNA-binding domain of VDR. Active vitamin D treatment did not ameliorate genu varum, rachitic changes in the roentgenogram, or abnormal laboratory findings. However, oral administration of calcium lactate dramatically improved these findings. The patient also experienced hair loss at two months of age and multiple papules on the skin at two yr of age, which did not improve with vitamin D or calcium supplementation. We also report the histopathological findings of skin papules in this patient. en-copyright= kn-copyright= en-aut-name=HasegawaKosei en-aut-sei=Hasegawa en-aut-mei=Kosei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyakeTomoko en-aut-sei=Miyake en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KobashiMina en-aut-sei=Kobashi en-aut-mei=Mina kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TetsunagaTomonori en-aut-sei=Tetsunaga en-aut-mei=Tomonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AgoYuko en-aut-sei=Ago en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FutagawaNatsuko en-aut-sei=Futagawa en-aut-mei=Natsuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MiyaharaHiroyuki en-aut-sei=Miyahara en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HiguchiYousuke en-aut-sei=Higuchi en-aut-mei=Yousuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MorizaneShin en-aut-sei=Morizane en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TsukaharaHirokazu en-aut-sei=Tsukahara en-aut-mei=Hirokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Dermatology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Dermatology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Dermatology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=rickets kn-keyword=rickets en-keyword=receptor kn-keyword=receptor en-keyword=alopecia kn-keyword=alopecia en-keyword=papules kn-keyword=papules en-keyword=calcium kn-keyword=calcium END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue=2 article-no= start-page=156 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250411 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clinical-level screening of sleep apnea syndrome with single-lead ECG alone is achievable using machine learning with appropriate time windows en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose To establish a simple and noninvasive screening test for sleep apnea (SA) that imposes less burden on potential patients. The specific objective of this study was to verify the effectiveness of past and future single-lead electrocardiogram (ECG) data from SA occurrence sites in improving the estimation accuracy of SA and sleep apnea syndrome (SAS) using machine learning.
Methods The Apnea-ECG dataset comprising 70 ECG recordings was used to construct various machine-learning models. The time window size was adjusted based on the accuracy of SA detection, and the performance of SA detection and SAS diagnosis (apnea?hypopnea index???5 was considered SAS) was compared.
Results Using ECG data from a few minutes before and after the occurrence of SAs improved the estimation accuracy of SA and SAS in all machine learning models. The optimal range of the time window and achieved accuracy for SAS varied by model; however, the sensitivity ranged from 95.7 to 100%, and the specificity ranged from 91.7 to 100%.
Conclusions ECG data from a few minutes before and after SA occurrence were effective in SA detection and SAS diagnosis, confirming that SA is a continuous phenomenon and that SA affects heart function over a few minutes before and after SA occurrence. Screening tests for SAS, using data obtained from single-lead ECGs with appropriate past and future time windows, should be performed with clinical-level accuracy. en-copyright= kn-copyright= en-aut-name=YamaneTakahiro en-aut-sei=Yamane en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujiiMasanori en-aut-sei=Fujii en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MoritaMizuki en-aut-sei=Morita en-aut-mei=Mizuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Biomedical Informatics, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=2 en-affil=Department of Geriatric Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Biomedical Informatics, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= en-keyword=Disease screening kn-keyword=Disease screening en-keyword=Sleep apnea syndrome (SAS) kn-keyword=Sleep apnea syndrome (SAS) en-keyword=Single-lead ECG kn-keyword=Single-lead ECG en-keyword=Artificial intelligence kn-keyword=Artificial intelligence en-keyword=Machine learning kn-keyword=Machine learning END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250410 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Enterobacterial common antigen repeat-unit flippase WzxE is required for Escherichia coli growth under acidic conditions, low temperature, and high osmotic stress conditions en-subtitle= kn-subtitle= en-abstract= kn-abstract=Colanic acid and enterobacterial common antigen (ECA) are cell-surface polysaccharides that are produced by many Escherichia coli isolates. Colanic acid is induced under acidic, low temperature, and high-salt conditions and is important for E. coli resistance to these stresses; however, the role of ECA in these stresses is less clear. Here, we observed that knockout of flippase wzxE, which translocates lipid-linked ECA repeat units from the cytoplasmic side of the inner membrane to the periplasmic side, resulted in the sensitivity of E. coli BW25113 to acidic conditions. The wzxE-knockout mutant showed reduced growth potential and viable counts in vegetable extracts with acidic environments, including cherry tomatoes, carrots, celery, lettuce, and spinach. A double-knockout strain of wzxE and wecF (glycosyltransferase that adds the third-and-final sugar of the lipid-linked ECA repeat unit) was not sensitive to acidic conditions, with similar results obtained for a double-knockout strain of wzxE and wcaJ (glycosyltransferase that initiates colanic acid lipid-linked repeat-unit biosynthesis). The wzxE-knockout mutant was sensitive to low temperatures or high-salt conditions, which induced colanic acid synthesis, and these sensitivities were abolished by the additional knockout of wcaJ. These results suggest that lipid-linked ECA repeat units confer E. coli susceptibility to acidic, low temperatures, and high-salt conditions in a colanic acid-dependent manner and that wzxE suppresses this negative effect. en-copyright= kn-copyright= en-aut-name=YamaguchiSaki en-aut-sei=Yamaguchi en-aut-mei=Saki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IshikawaKazuya en-aut-sei=Ishikawa en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FurutaKazuyuki en-aut-sei=Furuta en-aut-mei=Kazuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KaitoChikara en-aut-sei=Kaito en-aut-mei=Chikara kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=wzxE flippase kn-keyword=wzxE flippase en-keyword=enterobacterial common antigen kn-keyword=enterobacterial common antigen en-keyword=low pH kn-keyword=low pH en-keyword=low temperature kn-keyword=low temperature en-keyword=hyperosmotic stress kn-keyword=hyperosmotic stress END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue=7 article-no= start-page=2221 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Length Estimation of Pneumatic Artificial Muscle with Optical Fiber Sensor Using Machine Learning en-subtitle= kn-subtitle= en-abstract= kn-abstract=A McKibben artificial muscle is a soft actuator driven by air pressure, characterized by its flexibility, lightweight design, and high power-to-weight ratio. We have developed a smart artificial muscle that is capable of sensing its motion. To enable this sensing function, an optical fiber was integrated into the sleeve consisting of multiple fibers and serving as a component of the McKibben artificial muscle. By measuring the macrobending loss of the optical fiber, the length of the smart artificial muscle is expected to be estimated. However, experimental results indicated that the sensor's characteristics depend not only on the length but also on the load and the applied air pressure. This dependency arises because the stress applied to the optical fiber increases, causing microbending loss. In this study, we employed a machine learning model, primarily composed of Long Short-Term Memory (LSTM) neural networks, to estimate the length of the smart artificial muscle. The experimental results demonstrate that the length estimation obtained through machine learning exhibits a smaller error. This suggests that machine learning is a feasible approach to enhancing the length measurement accuracy of the smart artificial muscle. en-copyright= kn-copyright= en-aut-name=NiYilei en-aut-sei=Ni en-aut-mei=Yilei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WakimotoShuichi en-aut-sei=Wakimoto en-aut-mei=Shuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TianWeihang en-aut-sei=Tian en-aut-mei=Weihang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TodaYuichiro en-aut-sei=Toda en-aut-mei=Yuichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KandaTakefumi en-aut-sei=Kanda en-aut-mei=Takefumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamaguchiDaisuke en-aut-sei=Yamaguchi en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=McKibben artificial muscle kn-keyword=McKibben artificial muscle en-keyword=machine learning kn-keyword=machine learning en-keyword=optical fiber kn-keyword=optical fiber en-keyword=motion estimation kn-keyword=motion estimation END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue=7 article-no= start-page=2287 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250327 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Comparison of Midazolam and Diazepam for Sedation in Patients Undergoing Double-Balloon Endoscopic Retrograde Cholangiopancreatography: A Propensity Score-Matched Analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective: The sedation method used in double-balloon endoscopic retrograde cholangiopancreatography (DB-ERCP) varies across countries and between healthcare facilities. No previous studies have compared the effects of different benzodiazepines on sedation during endoscopic procedures. This study aimed to compare the effects of midazolam and diazepam sedation on DB-ERCP outcomes. Methods: This retrospective cohort study analyzed consecutive patients who underwent DB-ERCP between January 2017 and February 2024. A total of 203 patients who were sedated with diazepam (n = 94) or midazolam (n = 109) were analyzed. Propensity score matching was applied to adjust for baseline group differences. The primary outcome was the incidence of sedation-related adverse events (AEs). Secondary outcomes included inadequate sedation requiring additional sedatives and risk factors for sedation-related AEs. Results: Sedation-related AEs were more frequent with diazepam (28% [21/75]) than with midazolam (14% [11/75]; p = 0.046). Hypoxia occurred more frequently with diazepam (19% [14/75]) than with midazolam (5% [4/75]; p = 0.012). However, no significant differences were observed between the two groups for hypotension (p = 0.41) and bradycardia (p = 1.0). Poor sedation requiring other sedatives occurred significantly more often with diazepam (8% [6/75]) compared with midazolam sedation (0% [0/75], p = 0.012). Multivariate analysis identified diazepam sedation (odds ratio, 2.3; 95% confidence interval, 1.0-5.3; p = 0.048) as the sole risk factor for sedation-related AEs. Conclusions: Midazolam is safer and more effective than diazepam sedation in patients undergoing DB-ERCP. en-copyright= kn-copyright= en-aut-name=FujiiYuki en-aut-sei=Fujii en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsumotoKazuyuki en-aut-sei=Matsumoto en-aut-mei=Kazuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsumiAkihiro en-aut-sei=Matsumi en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiyamotoKazuya en-aut-sei=Miyamoto en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=UchidaDaisuke en-aut-sei=Uchida en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HoriguchiShigeru en-aut-sei=Horiguchi en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TsutsumiKoichiro en-aut-sei=Tsutsumi en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MitsuhashiToshiharu en-aut-sei=Mitsuhashi en-aut-mei=Toshiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OtsukaMotoyuki en-aut-sei=Otsuka en-aut-mei=Motoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=3 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=7 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=8 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= en-keyword=adverse events kn-keyword=adverse events en-keyword=balloon-assisted ERCP kn-keyword=balloon-assisted ERCP en-keyword=benzodiazepine kn-keyword=benzodiazepine en-keyword=sedation kn-keyword=sedation END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue=7 article-no= start-page=2242 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Impact of Lifestyle Changes on Body Weight Gain During Nationwide Lockdown Due to COVID-19 Pandemic en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: During the coronavirus disease 2019 (COVID-19) pandemic, people in Japan were urged to stay at home as much as possible, and this resulted in significant changes in lifestyle behavior. The new lifestyle included factors affecting both energy intake and energy consumption, and it is now thought that weight gain during the lockdown was the result of complex effects. The aim of this study was to determine the relationships among lifestyle habits, laboratory data, and body weight gain during the lockdown using medical check-up data. Methods: A total of 3789 individuals who had undergone consecutive medical check-ups during the period from 2018 to 2020 were included in this study. Participants whose body weight had increased by 5% or more were divided into two groups: a before-lockdown group (participants who had gained weight between 2018 and 2019) and an after-lockdown group (participants who had gained weight between 2019 and 2020). Physical measurements, laboratory data, and answers to six questions about lifestyle habits, for which information was obtained from the records from medical check-ups, were compared in the two groups. Results: There was no significant difference between the distribution of weight changes in 2018-2019 before the lockdown and the distribution of weight changes in 2019-2020 after the lockdown. The before-lockdown and after-lockdown groups both included about 7% of the total participants (279 and 273 participants, respectively). Diastolic blood pressure and levels of AST, ALT, and LDL-C were significantly higher in the after-lockdown group than in the before-lockdown group. The percentages of participants with alcohol consumption and exercise habits were significantly higher in the after-lockdown group than in the before-lockdown group, and an analysis by gender showed that the differences were significant for women but not for men. Conclusions: The distributions of weight changes before and during the COVID-19 pandemic were similar. Exercise habits and alcohol consumption might have been unique factors causing weight gain during the COVID-19 pandemic, particularly in women. Our findings suggest that the impact of behavioral restrictions and lifestyle changes during a pandemic may be different in men and women. en-copyright= kn-copyright= en-aut-name=NishidaChisa en-aut-sei=Nishida en-aut-mei=Chisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HondaHiroyuki en-aut-sei=Honda en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OtsukaYuki en-aut-sei=Otsuka en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakanoYasuhiro en-aut-sei=Nakano en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OguniKohei en-aut-sei=Oguni en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TokumasuKazuki en-aut-sei=Tokumasu en-aut-mei=Kazuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SakuradaYasue en-aut-sei=Sakurada en-aut-mei=Yasue kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ObikaMikako en-aut-sei=Obika en-aut-mei=Mikako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=COVID-19 pandemic kn-keyword=COVID-19 pandemic en-keyword=lockdown kn-keyword=lockdown en-keyword=weight gain kn-keyword=weight gain en-keyword=medical check-ups kn-keyword=medical check-ups en-keyword=lifestyle kn-keyword=lifestyle END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=2 article-no= start-page=100016 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202507 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells en-subtitle= kn-subtitle= en-abstract= kn-abstract=Glioblastoma cells are known to regulate their cellular plasticity in response to their surrounding microenvironment, but it is not fully understood what factors contribute to the cells' changing plasticity. Here, we found that glioblastoma cells alter the expression level of adrenoreceptors depending on their differentiation stage. Catecholamines are abundant in the central nervous system, and we found that noradrenaline, in particular, enhances the stemness of glioblastoma cells and promotes the dedifferentiation potential of already differentiated glioblastoma cells. Antagonist and RNAi experiments revealed that signaling through alpha 1D-adrenoreceptor is important for noradrenaline action on glioblastoma cells. We also found that high alpha 1Dadrenoreceptor expression was associated with poor prognosis in patients with gliomas. These data suggest that glioblastoma cells increase the expression level of their own adrenoreceptors to alter the surrounding tumor microenvironment favorably for survival. We believe that our findings will contribute to the development of new therapeutic strategies for glioblastoma. en-copyright= kn-copyright= en-aut-name=AsakaYutaro en-aut-sei=Asaka en-aut-mei=Yutaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MasumotoToshio en-aut-sei=Masumoto en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UnedaAtsuhito en-aut-sei=Uneda en-aut-mei=Atsuhito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ChinVanessa D. en-aut-sei=Chin en-aut-mei=Vanessa D. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OtaniYusuke en-aut-sei=Otani en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=PenaTirso en-aut-sei=Pena en-aut-mei=Tirso kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KatayamaHaruyoshi en-aut-sei=Katayama en-aut-mei=Haruyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ItanoTakuto en-aut-sei=Itano en-aut-mei=Takuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=AndoTeruhiko en-aut-sei=Ando en-aut-mei=Teruhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HuangRongsheng en-aut-sei=Huang en-aut-mei=Rongsheng kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=FujimuraAtsushi en-aut-sei=Fujimura en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Cellular Physiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Division of Health Administration and Promotion, Department of Social Medicine, Faculty of Medicine, Tottori University kn-affil= affil-num=3 en-affil=Department of Neurosurgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=UMass Chan Medical School, UMass Memorial Medical Center kn-affil= affil-num=5 en-affil=Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School kn-affil= affil-num=6 en-affil=Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School kn-affil= affil-num=7 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Trauma Orthopedics, The Second Hospital of Dalian Medical University kn-affil= affil-num=11 en-affil=Department of Cellular Physiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=Adrenoceptors kn-keyword=Adrenoceptors en-keyword=Glioma stem-like cells kn-keyword=Glioma stem-like cells en-keyword=Differentiated glioma cells kn-keyword=Differentiated glioma cells en-keyword=Noradrenaline kn-keyword=Noradrenaline en-keyword=Cellular plasticity kn-keyword=Cellular plasticity END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The association between objectively measured physical activity and home blood pressure: a population-based real-world data analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Few studies have examined the association of objectively measured habitual physical activity (PA) and sedentary behavior with out-of-office blood pressure (BP). We investigated the associations of objectively measured PA intensity time, sedentary time, and step count with at-home BP. Using accelerometer-recorded PA indices and self-measured BP in 368 participants (mean age, 53.8 years; 58.7% women), we analyzed 115,575 records of each parameter between May 2019 and April 2024. PA intensities were categorized as light (2.0?2.9 metabolic equivalents [METs]); moderate (3.0?5.9 METs); vigorous (?6.0 METs), or sedentary (<2.0 METs): the median [interquartile ranges] for these variables was 188 [146?232], 83 [59?114], 1 [0?2], 501 [428?579] minutes, respectively, and for step count, was 6040 [4164?8457]. Means [standard deviations] for systolic and diastolic BP were 116.4 [14.2] and 75.2 [9.3] mmHg, respectively. A mixed-effect model adjusted for possible confounders showed that 1-h longer in vigorous PA was associated with lower systolic and diastolic BP (?1.69 and ?1.09?mmHg, respectively). A 1000-step increase in step count was associated with lower systolic and diastolic BP (?0.05 and ?0.02?mmHg, respectively). Associations were more pronounced among men and participants aged <60 years. Sedentary time was positively associated with BP in men and participants aged <60 years, but inversely associated with BP in women and participants aged ?60 years. Our findings suggest that more PA and less sedentary behavior were associated with BP reduction, particularly among men and participants aged <60 years. However, the clinical relevance of this effect remains uncertain because of its modest magnitude. en-copyright= kn-copyright= en-aut-name=KinutaMinako en-aut-sei=Kinuta en-aut-mei=Minako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HisamatsuTakashi en-aut-sei=Hisamatsu en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TaniguchiKaori en-aut-sei=Taniguchi en-aut-mei=Kaori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FukudaMari en-aut-sei=Fukuda en-aut-mei=Mari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakahataNoriko en-aut-sei=Nakahata en-aut-mei=Noriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KandaHideyuki en-aut-sei=Kanda en-aut-mei=Hideyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Environmental Medicine and Public Health, Izumo, Shimane University Faculty of Medicine kn-affil= affil-num=4 en-affil=Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Health and Nutrition, The University of Shimane Faculty of Nursing and Nutrition kn-affil= affil-num=6 en-affil=Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol=213 cd-vols= no-issue= article-no= start-page=128 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The potential mechanism maintaining transactive response DNA binding protein 43?kDa in the mouse stroke model en-subtitle= kn-subtitle= en-abstract= kn-abstract=The disruption of transactive response DNA binding protein 43?kDa (TDP-43) shuttling leads to the depletion of nuclear localization and the cytoplasmic accumulation of TDP-43. We aimed to evaluate the mechanism underlying the behavior of TDP-43 in ischemic stroke. Adult male C57BL/6?J mice were subjected to 30 or 60?min of transient middle cerebral artery occlusion (tMCAO), and examined at 1, 6, and 24?h post reperfusion. Immunostaining was used to evaluate the expression of TDP-43, G3BP1, HDAC6, and RAD23B. The total and cytoplasmic number of TDP-43?positive cells increased compared with sham operation group and peaked at 6?h post reperfusion after tMCAO. The elevated expression of G3BP1 protein peaked at 6?h after reperfusion and decreased at 24?h after reperfusion in ischemic mice brains. We also observed an increase of expression level of HDAC6 and the number of RAD23B-positive cells increased after tMCAO. RAD23B was colocalized with TDP-43 24?h after tMCAO. We proposed that the formation of stress granules might be involved in the mislocalization of TDP-43, based on an evaluation of G3BP1 and HDAC6. Subsequently, RAD23B, may also contribute to the downstream degradation of mislocalized TDP-43 in mice tMCAO model. en-copyright= kn-copyright= en-aut-name=BianYuting en-aut-sei=Bian en-aut-mei=Yuting kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FukuiYusuke en-aut-sei=Fukui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=Ota-ElliottRicardo Satoshi en-aut-sei=Ota-Elliott en-aut-mei=Ricardo Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HuXinran en-aut-sei=Hu en-aut-mei=Xinran kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SunHongming en-aut-sei=Sun en-aut-mei=Hongming kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=BianZhihong en-aut-sei=Bian en-aut-mei=Zhihong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ZhaiYun en-aut-sei=Zhai en-aut-mei=Yun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YuHaibo en-aut-sei=Yu en-aut-mei=Haibo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HuXiao en-aut-sei=Hu en-aut-mei=Xiao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=AnHangping en-aut-sei=An en-aut-mei=Hangping kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=LiuHongzhi en-aut-sei=Liu en-aut-mei=Hongzhi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=IshiuraHiroyuki en-aut-sei=Ishiura en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=13 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=14 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=TDP-43 kn-keyword=TDP-43 en-keyword=ALS kn-keyword=ALS en-keyword=RNA-binding protein kn-keyword=RNA-binding protein en-keyword=Mislocalization kn-keyword=Mislocalization en-keyword=G3BP1 kn-keyword=G3BP1 en-keyword=HDAC6 kn-keyword=HDAC6 en-keyword=RAD23B kn-keyword=RAD23B en-keyword=tMCAO kn-keyword=tMCAO END start-ver=1.4 cd-journal=joma no-vol=17 cd-vols= no-issue=4 article-no= start-page=e82348 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250416 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Bilateral Scleritis and Neutrophilic Dermatosis With Cytogenetic Chromosomal Aberrancy Related to Pyoderma Gangrenosum: A Case Report of a 20-Year Follow-Up en-subtitle= kn-subtitle= en-abstract= kn-abstract=Pyoderma gangrenosum is a non-infectious autoimmune disease with skin plaques and ulcers in the entity of neutrophilic dermatosis and may have a background of myelodysplastic syndromes. This study reported a 20-year follow-up of a patient with pyoderma gangrenosum and scleritis who showed chromosomal aberrancy from the initial phase and later in the course developed thrombocythemia. A 51-year-old man presented with widespread indurated erythematous plaques with scaling and pustules on the forehead, bilateral eyelids, and nasal bridge, in addition to nodular scleritis in the left eye and ulcer formation of the plaques in the lower legs. Skin biopsy revealed massive dermal infiltration mainly with neutrophils in the absence of neutrophilic vasculitis. Suspected of myelodysplastic syndromes, bone marrow biopsy was normal, while chromosomal aberrancy, 46, XY, del (20) (q11q13.3), was detected. In the diagnosis of neutrophilic dermatosis, probably of pyoderma gangrenosum, he began to have oral prednisolone 20 mg daily and colchicine 1 mg daily, leading to the subsidence of skin lesions. Four months later, he developed nodular scleritis in the right eye and began to use topical 0.1% betamethasone in both eyes. He was stable with only prednisolone 12.5 mg daily until the age of 55.5 years, when he showed an increase of serum lactate dehydrogenase. The bone marrow aspirate disclosed neither blast cell increase nor atypical cells. The same chromosomal aberrancy was repeatedly detected. One year later, he developed breathing difficulty and underwent tracheostomy. Laryngeal lesion biopsy disclosed squamous cell papilloma with human papillomavirus-6. At 60 years old, he showed marginal corneal infiltration in the left eye, and at 61 years old, hypopyon in the right eye. Platelets tended to increase up to 1000 ~ 103/?L, and bone marrow examinations were recommended but refused by the patient. At the latest follow-up at 71 years old, he was ambulatory in health and stable with a tracheostomy cannula. In conclusion, pyoderma gangrenosum with scleritis occurred in an undetermined hematological malignancy with chromosomal aberrancy. en-copyright= kn-copyright= en-aut-name=MatsuoToshihiko en-aut-sei=Matsuo en-aut-mei=Toshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AsadaNoboru en-aut-sei=Asada en-aut-mei=Noboru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ObikaMikako en-aut-sei=Obika en-aut-mei=Mikako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OmichiRyotaro en-aut-sei=Omichi en-aut-mei=Ryotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IwatsukiKeiji en-aut-sei=Iwatsuki en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Ophthalmology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=2 en-affil=Department of Pathology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Hematology and Oncology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of General Internal Medicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Dermatology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=corneal infiltration kn-keyword=corneal infiltration en-keyword=hypopyon kn-keyword=hypopyon en-keyword=myelodysplastic syndromes kn-keyword=myelodysplastic syndromes en-keyword=neutrophilic dermatosis kn-keyword=neutrophilic dermatosis en-keyword=peripheral keratitis kn-keyword=peripheral keratitis en-keyword=pyoderma gangrenosum kn-keyword=pyoderma gangrenosum en-keyword=scleritis kn-keyword=scleritis en-keyword=sweet syndrome kn-keyword=sweet syndrome END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=1 article-no= start-page=141 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Primary chest wall sarcoma: advances in surgical management and outcomes en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose Although rare, primary chest wall sarcomas are complex malignancies necessitating optimal local control and comprehensive treatment. This study aimed to review 9 years of cases of primary chest wall sarcomas at a single institution, focusing on their histology, surgical management, and prognosis.
Methods A retrospective analysis was performed on 19 patients undergoing chest wall resection for sarcoma from 2012 to 2020. Data on demographics, tumor specifics, resection extent, and adjuvant therapies were collected. Surgical and postoperative outcomes were also assessed.
Results The median patient age was 64 years. Chondrosarcoma was the most common histology. R0 resection was achieved in all patients, with early postoperative complications occurring in 11% of the patients. Robust chest wall reconstruction was performed, resulting in minimal respiratory complications. The 5-year overall survival and disease-free survival rates were 94% and 68%, respectively. Tumor size and patient age were significant prognostic factors for local recurrence.
Conclusion Comprehensive surgical resection, coupled with multidisciplinary preoperative planning, achieves favorable outcomes. Patients aged???70 years and with tumor size???5 cm (P?=?.047) should be carefully followed up for local recurrence. en-copyright= kn-copyright= en-aut-name=TanakaShin en-aut-sei=Tanaka en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakataEiji en-aut-sei=Nakata en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=RyukoTsuyoshi en-aut-sei=Ryuko en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ItanoTakuto en-aut-sei=Itano en-aut-mei=Takuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TomiokaYasuaki en-aut-sei=Tomioka en-aut-mei=Yasuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShienKazuhiko en-aut-sei=Shien en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SuzawaKen en-aut-sei=Suzawa en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MiyoshiKentaroh en-aut-sei=Miyoshi en-aut-mei=Kentaroh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OkazakiMikio en-aut-sei=Okazaki en-aut-mei=Mikio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=SugimotoSeiichiro en-aut-sei=Sugimoto en-aut-mei=Seiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Orthopedic Surgery, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Orthopedic Surgery, Okayama University Hospital kn-affil= affil-num=12 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Primary chest wall sarcomas kn-keyword=Primary chest wall sarcomas en-keyword=Chest wall resection kn-keyword=Chest wall resection en-keyword=Chondrosarcoma kn-keyword=Chondrosarcoma en-keyword=Robust chest wall reconstruction kn-keyword=Robust chest wall reconstruction END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=— •\Ž†E‰p•¶–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=“Še‹K’öE‰œ•t en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=47 end-page=55 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Practical BIZEN Device Design Course Activity Report in Fiscal 2024 kn-title=2024”N“xŽŸ¢‘ãˆã—Ë@ŠíŠJ”­lވ笃vƒƒOƒ‰ƒ€BIZENƒfƒoƒCƒXƒfƒUƒCƒ“ƒR[ƒX‚ÌŽæ‚è‘g‚Ý en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TSUZUKITsuneaki en-aut-sei=TSUZUKI en-aut-mei=Tsuneaki kn-aut-name=“s’zí–¾ kn-aut-sei=“s’z kn-aut-mei=í–¾ aut-affil-num=1 ORCID= en-aut-name=UCHIDADaisuke en-aut-sei=UCHIDA en-aut-mei=Daisuke kn-aut-name=“à“c‘å•ã kn-aut-sei=“à“c kn-aut-mei=‘å•ã aut-affil-num=2 ORCID= en-aut-name=KISHIMOTOToshio en-aut-sei=KISHIMOTO en-aut-mei=Toshio kn-aut-name=ŠÝ–{r•v kn-aut-sei=ŠÝ–{ kn-aut-mei=r•v aut-affil-num=3 ORCID= en-aut-name=SENGOKUYoshinari en-aut-sei=SENGOKU en-aut-mei=Yoshinari kn-aut-name=åΊì–ç kn-aut-sei=åÎ kn-aut-mei=Šì–ç aut-affil-num=4 ORCID= en-aut-name=KORENAGAToshio en-aut-sei=KORENAGA en-aut-mei=Toshio kn-aut-name=ˆÉ‰ir—Y kn-aut-sei=ˆÉ‰i kn-aut-mei=r—Y aut-affil-num=5 ORCID= en-aut-name=HITOBEYu en-aut-sei=HITOBE en-aut-mei=Yu kn-aut-name=l•”—F kn-aut-sei=l•” kn-aut-mei=—F aut-affil-num=6 ORCID= en-aut-name=YOSHIBAYasuyuki en-aut-sei=YOSHIBA en-aut-mei=Yasuyuki kn-aut-name=‹g—t‹±s 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en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=8 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@ Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=39 end-page=45 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Practicing the Innovation Loop: 2024 Report on Advanced Hospital Practicums and Future Challenges kn-title=ƒCƒmƒx[ƒVƒ‡ƒ“ƒ‹[ƒv‚ÌŽÀ‘HF2024”N“xæi•a‰@ŽÀK•ñ‚Æ–¢—ˆ‰Û‘è en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HARADANahoko en-aut-sei=HARADA en-aut-mei=Nahoko kn-aut-name=Œ´“c“Þ•äŽq kn-aut-sei=Œ´“c kn-aut-mei=“Þ•äŽq aut-affil-num=1 ORCID= en-aut-name=TAKAHASHISatoshi en-aut-sei=TAKAHASHI en-aut-mei=Satoshi kn-aut-name=ûü‹´’q kn-aut-sei=ûü‹´ kn-aut-mei=’q aut-affil-num=2 ORCID= en-aut-name=MORITomoaki en-aut-sei=MORI en-aut-mei=Tomoaki kn-aut-name=X—F–¾ kn-aut-sei=X kn-aut-mei=—F–¾ aut-affil-num=3 ORCID= en-aut-name=HIKASAHaruka en-aut-sei=HIKASA en-aut-mei=Haruka kn-aut-name=“úŠ}° kn-aut-sei=“úŠ} kn-aut-mei=° aut-affil-num=4 ORCID= en-aut-name=SHISHIDOKeisuke en-aut-sei=SHISHIDO en-aut-mei=Keisuke kn-aut-name=Ž³ŒËŒ\‰î kn-aut-sei=Ž³ŒË kn-aut-mei=Œ\‰î aut-affil-num=5 ORCID= en-aut-name=MAGARIMasaki en-aut-sei=MAGARI en-aut-mei=Masaki kn-aut-name=‹È³Ž÷ kn-aut-sei=‹È kn-aut-mei=³Ž÷ aut-affil-num=6 ORCID= en-aut-name=WATANABEToyohiko en-aut-sei=WATANABE en-aut-mei=Toyohiko kn-aut-name=“nç³–L•F kn-aut-sei=“nç³ kn-aut-mei=–L•F aut-affil-num=7 ORCID= en-aut-name=WangJin en-aut-sei=Wang en-aut-mei=Jin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MORITAMizuki en-aut-sei=MORITA en-aut-mei=Mizuki kn-aut-name=X“cŽ÷ kn-aut-sei=X“c kn-aut-mei=Ž÷ aut-affil-num=9 ORCID= affil-num=1 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=2 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=3 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=4 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=5 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=6 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=7 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=8 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=9 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=35 end-page=37 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 16th International Symposium for Future Technology Creating Better Human Health and Society kn-title=‘æ16‰ñ ‚“xˆã—ÓsŽs‚ð‘no‚·‚é–¢—ˆ‹Zp‘ÛƒVƒ“ƒ|ƒWƒEƒ€ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YANGJiajia en-aut-sei=YANG en-aut-mei=Jiajia kn-aut-name=—k‰Æ‰Æ kn-aut-sei=—k kn-aut-mei=‰Æ‰Æ aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ª??ŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=29 end-page=33 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Survey of Private Collections gKyoson Collectionsh in Okayama University Library: Focusing on His Friendship with Poets kn-title=‰ªŽR‘åŠw’†‰›}‘ŠÙEŒÂl•¶ŒÉuˆÇ‘º•¶ŒÉv‚Ì’²¸FŽl‚Æ‚ÌŒð—F‚ð’†S‚É en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SUZUKIRyozo en-aut-sei=SUZUKI en-aut-mei=Ryozo kn-aut-name=—é–Ø—ºŽO kn-aut-sei=—é–Ø kn-aut-mei=—ºŽO aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=19 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Review of Previous Research on the Use of PrEP: Focusing on Japan and China kn-title=PrEP ‚Ì—˜—p‚ÉŠÖ‚·‚éæsŒ¤‹†ƒŒƒrƒ…[“ú–{‚Æ’†‘‚ð’†S‚É en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WangDecheng en-aut-sei=Wang en-aut-mei=Decheng kn-aut-name=ŸŠ“¿¬ kn-aut-sei=ŸŠ kn-aut-mei=“¿¬ aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŒ¤‹†‰È en-keyword=PrEP (Pre-exposure Prophylaxis) kn-keyword=PrEP (Pre-exposure Prophylaxis) en-keyword=HIV Prevention kn-keyword=HIV Prevention en-keyword=Social Stigma kn-keyword=Social Stigma en-keyword=Policy Support kn-keyword=Policy Support en-keyword=Regional Disparities kn-keyword=Regional Disparities END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=11 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An examination of decision-making support at the end of life on relational autonomy theory kn-title=ŠÖŒW“IŽ©—¥—˜_‚ÉŠî‚¢‚½I––Šú‚ÉŠÖ‚·‚éˆÓŽvŒˆ’èŽx‰‡‚ÌŒŸ“¢ en-subtitle= kn-subtitle= en-abstract= kn-abstract=In contemporary end-of-life care, it is difficult for patients to make decisions without the influence of society, family, and other factors. In many cases, patients have the capacity to make the decisions; nevertheless, they have difficulty expressing their own will because of the influence of their relationships and environment. Patient concerns about the burden of care and also the social and economic impacts on family members often hinder their use of imagination and decision-making. Therefore, this study has examined how patients with decision-making capacities could achieve autonomy under the influence of their relationships with their surroundings. The method of decision-making support provided by nurses to patients was examined using relational autonomy theory. Relational autonomy theory attempts to reconceptualize autonomy through feminists who criticize individualist theories of autonomy. en-copyright= kn-copyright= en-aut-name=SONOYAMASumiyo en-aut-sei=SONOYAMA en-aut-mei=Sumiyo kn-aut-name=‰€ŽRƒ‘ã kn-aut-sei=‰€ŽR kn-aut-mei=ƒ‘ã aut-affil-num=1 ORCID= affil-num=1 en-affil=The University of Shimane kn-affil=“‡ªŒ§—§‘åŠw en-keyword=relational autonomy kn-keyword=relational autonomy en-keyword=decision-making kn-keyword=decision-making en-keyword=end of life care kn-keyword=end of life care END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=1 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Corporate decision-making process for exploration time kn-title=’m‚Ì’TõŽžŠÔ‚ɂ‚¢‚Ä‚ÌŠé‹Æ‚̈ӎvŒˆ’èƒvƒƒZƒX en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order for companies to innovate through business co-creation, it is necessary to explore a wide range of external knowledge and technologies. However, there is no clear answer as to how much time should be spent for exploration. Under these circumstances, companies must take into account constraints such as the amount of management resources that can be invested, and make decisions about the time to spend for exploration. The purpose of this paper is to clarify the process of how companies that have introduced corporate accelerator program recognize the relationship between the program period and the results of business co-creation, and how they make decisions about the program period. We conducted a case study of several companies that have introduced corporate accelerator program in Japan. In addition, this paper established a hypothesis about decision-making about the time for exploration from case studies. en-copyright= kn-copyright= en-aut-name=SHIMIZUTakeshi en-aut-sei=SHIMIZU en-aut-mei=Takeshi kn-aut-name=Žu…•Žj kn-aut-sei=Žu… kn-aut-mei=•Žj aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems Okayama University kn-affil=‘—§‘åŠw–@l‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŒ¤‹†Šwˆæ en-keyword=corporate accelerator program kn-keyword=corporate accelerator program en-keyword=co-creation kn-keyword=co-creation en-keyword=exploration kn-keyword=exploration en-keyword=Time Compression Diseconomies kn-keyword=Time Compression Diseconomies END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž†E–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=37 cd-vols= no-issue=1 article-no= start-page=16 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The preoperative flexion tear gap affects postoperative meniscus stability after pullout repair for medial meniscus posterior root tear en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background We investigated whether the preoperative flexion tear gap (FTG) observed in open magnetic resonance imaging (MRI) affects meniscus stability after medial meniscus (MM) posterior root (MMPR) repairs. Furthermore, time-correlated MRI findings from MMPR tear occurrence were evaluated.
Methods This retrospective observational study included 54 patients (mean age, 64.6 years; 13 males and 41 females) who underwent pullout repair for radial degenerative MMPR tear. Meniscus stability (scored 0-4 points) was assessed using a semi-quantitative arthroscopic scoring system during second-look arthroscopy 1 year postoperatively. The FTG was evaluated on preoperative axial MRI at 90 degrees knee flexion. Other MRI measurements included MM extrusion (MME) at 10 degrees knee flexion, MM posterior extrusion (MMPE) at 90 degrees knee flexion, and MM posteromedial extrusion (MMpmE) at 90 degrees knee flexion preoperatively and 1 year postoperatively. The correlation between the arthroscopic stability score and MRI findings was investigated. A receiver-operating characteristic curve was calculated to predict a good meniscus healing score (3-4 points). The correlation between the FTG and patient demographics, including time from injury to MRI, was analyzed.
Results At 1 year postoperatively, MME increased by 1.1 mm, while MMpmE and MMPE decreased by 0.4 mm and 1.0 mm, respectively. The meniscus stability score was negatively correlated with the preoperative FTG (r = -0.61, p < 0.01). The time from injury to MRI was significantly correlated with the preoperative FTG. The receiver-operating characteristic curve identified an FTG cut-off value of 8.7 mm for predicting good postoperative stability, with sensitivity and specificity of 67% and 85%, respectively.
Conclusions FTG evaluated with open MRI at 90 degrees knee flexion was associated with time from injury and affected meniscus stability following pullout repair. MMPR tears should be treated in the early phase to increase meniscus healing stability. en-copyright= kn-copyright= en-aut-name=TamuraMasanori en-aut-sei=Tamura en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FurumatsuTakayuki en-aut-sei=Furumatsu en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KitayamaTakahiro en-aut-sei=Kitayama en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YokoyamaYusuke en-aut-sei=Yokoyama en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkazakiYuki en-aut-sei=Okazaki en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KawadaKoki en-aut-sei=Kawada en-aut-mei=Koki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=Medial meniscus kn-keyword=Medial meniscus en-keyword=Posterior root tear kn-keyword=Posterior root tear en-keyword=Distance kn-keyword=Distance en-keyword=Pullout repair kn-keyword=Pullout repair en-keyword=Second-look arthroscopy kn-keyword=Second-look arthroscopy END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue=3 article-no= start-page=e0320482 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Serum uric acid level is associated with renal arteriolar hyalinosis and predicts post-donation renal function in living kidney donors en-subtitle= kn-subtitle= en-abstract= kn-abstract=Major guidelines for living-donor kidney transplantation underscore the need for pre-donation evaluation of renal function, hypertension, obesity, diabetes mellitus, and albuminuria to minimize the risk of donation from marginal donors. However, validity is yet to be established. We retrospectively investigated the relationship between clinical characteristics and histological indices in baseline renal biopsies (0-h biopsies) and whether these parameters could predict renal function in living kidney donors one year post-donation. Seventy-six living kidney donors were recruited for this study. In histological analyses, glomerulosclerosis, arteriosclerosis, arteriolosclerosis, arteriolar hyalinosis, and interstitial fibrosis and tubular atrophy scores/indices were evaluated. Post-donation serum creatinine levels in kidney donors with arteriolar hyalinosis were significantly higher than those in individuals without arteriolar hyalinosis. There was a significant correlation between baseline serum uric acid levels and the arteriolar hyalinosis index, with baseline uric acid level identified as an independent factor for hyalinosis in multiple regression analysis. Additionally, the serum uric acid level was a significant prognostic factor for post-donation serum creatinine after adjustment for baseline clinical parameters. These data demonstrate that pre-donation serum uric acid levels are associated with arteriolar hyalinosis in the kidney and could predict a decline in renal function during the first year after donation in living kidney donors. en-copyright= kn-copyright= en-aut-name=KanoYuzuki en-aut-sei=Kano en-aut-mei=Yuzuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanabeKatsuyuki en-aut-sei=Tanabe en-aut-mei=Katsuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KitagawaMasashi en-aut-sei=Kitagawa en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SugiyamaHitoshi en-aut-sei=Sugiyama en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamanoiTomoaki en-aut-sei=Yamanoi en-aut-mei=Tomoaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YoshinagaKasumi en-aut-sei=Yoshinaga en-aut-mei=Kasumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=BekkuKensuke en-aut-sei=Bekku en-aut-mei=Kensuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NishimuraShingo en-aut-sei=Nishimura en-aut-mei=Shingo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Medicine, Kawasaki Medical School General Medical Center and Department of Medical Care Work, Kawasaki College of Health Professions kn-affil= affil-num=5 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=4 article-no= start-page=e70139 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Induction Therapy With Oral Tacrolimus Provides Long-Term Benefit in Thiopurine-Na?ve Refractory Ulcerative Colitis Patients Despite Low Serum Albumin Levels en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background and Aim: Oral tacrolimus is an effective treatment for refractory ulcerative colitis (UC). However, tacrolimus is underutilized because of the difficulties in transitioning to subsequent maintenance therapy and concerns about adverse events.
Methods: We evaluated the clinical outcomes, adverse events, and accumulated medication costs in consecutive 72 UC patients treated with tacrolimus.
Results: Fifty-five (76%) patients with pancolitis and 43 (60%) patients with acute severe disease were entered. Fifty-four (75%) achieved clinical remission 8 weeks after starting tacrolimus. At the last visit, 62 (86%) patients had colectomy-free remission, and 55 (76%) patients had corticosteroid-free remission. Eighteen (25%) patients maintained remission without additional treatment after tacrolimus discontinuation. Patients with continuous remission had a significantly lower history of thiopurine use and lower serum albumin levels at the induction of tacrolimus than patients with failure to induce or maintain remission. No severe adverse events due to tacrolimus treatment were observed. The accumulated medication costs over 3 years in patients with continuous remission after the start of tacrolimus were lower than those in patients with induction and maintenance of infliximab (p < 0.001).
Conclusions: Tacrolimus could have an irreplaceable role in the era of biologic therapies, especially for refractory UC patients with thiopurine-na & iuml;ve and low serum albumin levels. en-copyright= kn-copyright= en-aut-name=IgawaShoko en-aut-sei=Igawa en-aut-mei=Shoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=InokuchiToshihiro en-aut-sei=Inokuchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HiraokaSakiko en-aut-sei=Hiraoka en-aut-mei=Sakiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ToyosawaJunki en-aut-sei=Toyosawa en-aut-mei=Junki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AoyamaYuki en-aut-sei=Aoyama en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamasakiYasushi en-aut-sei=Yamasaki en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KinugasaHideaki en-aut-sei=Kinugasa en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakaharaMasahiro en-aut-sei=Takahara en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OtsukaMotoyuki en-aut-sei=Otsuka en-aut-mei=Motoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=biologics therapy kn-keyword=biologics therapy en-keyword=tacrolimus kn-keyword=tacrolimus en-keyword=thiopurine kn-keyword=thiopurine en-keyword=ulcerative colitis kn-keyword=ulcerative colitis END start-ver=1.4 cd-journal=joma no-vol=50 cd-vols= no-issue=1 article-no= start-page=100 end-page=107 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Investigating the Effects of Reconstruction Conditions on Image Quality and Radiomic Analysis in Photon-counting Computed Tomography en-subtitle= kn-subtitle= en-abstract= kn-abstract=Introduction:Photon-counting computed tomography (CT) is equipped with an adaptive iterative reconstruction method called quantum iterative reconstruction (QIR), which allows the intensity to be changed during image reconstruction. It is known that the reconstruction conditions of CT images affect the analysis results when performing radiomic analysis. The aim of this study is to investigate the effect of QIR intensity on image quality and radiomic analysis of renal cell carcinoma (RCC).
Materials and Methods:The QIR intensities were selected as off, 2 and 4. The image quality evaluation items considered were task-based transfer function (TTF), noise power spectrum (NPS), and low-contrast object specific contrast-to-noise ratio (CNRLO). The influence on radiomic analysis was assessed using the discrimination accuracy of clear cell RCC.
Results:For image quality evaluation, TTF and NPS values were lower and CNRLO values were higher with increasing QIR intensity; for radiomic analysis, sensitivity, specificity, and accuracy were higher with increasing QIR intensity. Principal component analysis and receiver operating characteristics analysis also showed higher values with increasing QIR intensity.
Conclusion:It was confirmed that the intensity of the QIR intensity affects both the image quality and the radiomic analysis. en-copyright= kn-copyright= en-aut-name=OhataMiyu en-aut-sei=Ohata en-aut-mei=Miyu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FukuiRyohei en-aut-sei=Fukui en-aut-mei=Ryohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MorimitsuYusuke en-aut-sei=Morimitsu en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KobayashiDaichi en-aut-sei=Kobayashi en-aut-mei=Daichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamauchiTakatsugu en-aut-sei=Yamauchi en-aut-mei=Takatsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AkagiNoriaki en-aut-sei=Akagi en-aut-mei=Noriaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HondaMitsugi en-aut-sei=Honda en-aut-mei=Mitsugi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HayashiAiko en-aut-sei=Hayashi en-aut-mei=Aiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HasegawaKoshi en-aut-sei=Hasegawa en-aut-mei=Koshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KidaKatsuhiro en-aut-sei=Kida en-aut-mei=Katsuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=GotoSachiko en-aut-sei=Goto en-aut-mei=Sachiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Division of Radiological Technology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Division of Radiological Technology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Division of Radiological Technology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Division of Radiological Technology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Division of Radiological Technology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Radiology, Hiroshima University Hospital kn-affil= affil-num=9 en-affil=Department of Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical, Okayama University kn-affil= en-keyword=Image quality kn-keyword=Image quality en-keyword=photon-counting computed tomography kn-keyword=photon-counting computed tomography en-keyword=quantum iterative reconstruction kn-keyword=quantum iterative reconstruction en-keyword=radiomics kn-keyword=radiomics en-keyword=renal cell carcinoma kn-keyword=renal cell carcinoma END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=10462 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250326 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Gingipain regulates isoform switches of PD-L1 in macrophages infected with Porphyromonas gingivalis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Periodontal pathogen Porphyromonas gingivalis (P. gingivalis) is believed to possess immune evasion capabilities, but it remains unclear whether this immune evasion is related to host gene alternative splicing (AS). In this study, RNA-sequencing revealed significant changes in both AS landscape and transcriptomic profile of macrophages following P. gingivalis infection with/without knockout of gingipain (a unique toxic protease of P. gingivalis). P. gingivalis infection increased the PD-L1 transcripts expression and selectively upregulated a specific coding isoform that more effectively binds to PD-1 on T cells, thereby inhibiting immune function. Biological experiments also detected AS switch of PD-L1 in P. gingivalis-infected or gingipain-treated macrophages. AlphaFold 3 predictions indicated that the protein docking compatibility between PD-1 and P. gingivalis-upregulated PD-L1 isoform was over 80% higher than another coding isoform. These findings suggest that P. gingivalis employs gingipain to modulate the AS of PD-L1, facilitating immune evasion. en-copyright= kn-copyright= en-aut-name=ZhengYilin en-aut-sei=Zheng en-aut-mei=Yilin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WangZiyi en-aut-sei=Wang en-aut-mei=Ziyi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WengYao en-aut-sei=Weng en-aut-mei=Yao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SitosariHeriati en-aut-sei=Sitosari en-aut-mei=Heriati kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HeYuhan en-aut-sei=He en-aut-mei=Yuhan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ZhangXiu en-aut-sei=Zhang en-aut-mei=Xiu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShiotsuNoriko en-aut-sei=Shiotsu en-aut-mei=Noriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=FukuharaYoko en-aut-sei=Fukuhara en-aut-mei=Yoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=IkegameMika en-aut-sei=Ikegame en-aut-mei=Mika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OkamuraHirohiko en-aut-sei=Okamura en-aut-mei=Hirohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama University kn-affil= affil-num=2 en-affil=Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama University kn-affil= affil-num=4 en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama University kn-affil= affil-num=5 en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama University kn-affil= affil-num=6 en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama University kn-affil= affil-num=7 en-affil=Comprehensive Dental Clinic, Okayama University Hospital, Okayama University kn-affil= affil-num=8 en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama University kn-affil= affil-num=9 en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama University kn-affil= affil-num=10 en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama University kn-affil= en-keyword=Porphyromonas gingivalis kn-keyword=Porphyromonas gingivalis en-keyword=Gingipain kn-keyword=Gingipain en-keyword=Macrophage kn-keyword=Macrophage en-keyword=Alternative splicing kn-keyword=Alternative splicing en-keyword=PD-L1 kn-keyword=PD-L1 en-keyword=Immune evasion kn-keyword=Immune evasion END start-ver=1.4 cd-journal=joma no-vol=18 cd-vols= no-issue=3 article-no= start-page=143 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250304 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Hair Drawing Evaluation Algorithm for Exactness Assessment Method in Portrait Drawing Learning Assistant System en-subtitle= kn-subtitle= en-abstract= kn-abstract=Nowadays, portrait drawing has become increasingly popular as a means of developing artistic skills and nurturing emotional expression. However, it is challenging for novices to start learning it, as they usually lack a solid grasp of proportions and structural foundations of the five senses. To address this problem, we have studied Portrait Drawing Learning Assistant System (PDLAS) for guiding novices by providing auxiliary lines of facial features, generated by utilizing OpenPose and OpenCV libraries. For PDLAS, we have also presented the exactness assessment method to evaluate drawing accuracy using the Normalized Cross-Correlation (NCC) algorithm. It calculates the similarity score between the drawing result and the initial portrait photo. Unfortunately, the current method does not assess the hair drawing, although it occupies a large part of a portrait and often determines its quality. In this paper, we present a hair drawing evaluation algorithm for the exactness assessment method to offer comprehensive feedback to users in PDLAS. To emphasize hair lines, this algorithm extracts the texture of the hair region by computing the eigenvalues and eigenvectors of the hair image. For evaluations, we applied the proposal to drawing results by seven students from Okayama University, Japan and confirmed the validity. In addition, we observed the NCC score improvement in PDLAS by modifying the face parts with low similarity scores from the exactness assessment method. en-copyright= kn-copyright= en-aut-name=ZhangYue en-aut-sei=Zhang en-aut-mei=Yue kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FunabikiNobuo en-aut-sei=Funabiki en-aut-mei=Nobuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FebriantiErita Cicilia en-aut-sei=Febrianti en-aut-mei=Erita Cicilia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SudarsonoAmang en-aut-sei=Sudarsono en-aut-mei=Amang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HsuChenchien en-aut-sei=Hsu en-aut-mei=Chenchien kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Information and Communication Systems, Okayama University kn-affil= affil-num=2 en-affil=Department of Information and Communication Systems, Okayama University kn-affil= affil-num=3 en-affil=Department of Electrical Engineering, Politeknik Elektronika Negeri Surabaya kn-affil= affil-num=4 en-affil=Department of Electrical Engineering, Politeknik Elektronika Negeri Surabaya kn-affil= affil-num=5 en-affil=Department of Electrical Engineering, National Taiwan Normal University kn-affil= en-keyword=portrait drawing kn-keyword=portrait drawing en-keyword=auxiliary lines kn-keyword=auxiliary lines en-keyword=OpenPose kn-keyword=OpenPose en-keyword=OpenCV kn-keyword=OpenCV en-keyword=normalized cross-correlation (NCC) kn-keyword=normalized cross-correlation (NCC) en-keyword=hair texture kn-keyword=hair texture en-keyword=exactness assessment method kn-keyword=exactness assessment method END start-ver=1.4 cd-journal=joma no-vol=96 cd-vols= no-issue=3 article-no= start-page=033907 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Development of density measurement at high pressure and high temperature using the x-ray absorption method combined with laser-heated diamond anvil cell en-subtitle= kn-subtitle= en-abstract= kn-abstract=The densities of liquid materials at high pressures and high temperatures are important information to understand the elastic behavior of liquids at extreme conditions, which is closely related to the formation and evolution processes of the Earth and planetary interiors. The x-ray absorption method is an effective method to measure the density of non-crystalline materials at high pressures. However, the temperature condition of the x-ray absorption method using a diamond anvil cell (DAC) has been limited to 720 K to date. To significantly expand the measurable temperature condition of this method, in this study, we developed a density measurement technique using the x-ray absorption method in combination with a laser-heated DAC. The density of solid Ni was measured up to 26 GPa and 1800 K using the x-ray absorption method and evaluated by comparison with the density obtained from the x-ray diffraction. The density of solid Ni with a thickness >17 ƒÊm was determined with an accuracy of 0.01%?2.2% (0.001?0.20 g/cm3) and a precision of 0.8%?1.8% (0.07?0.16 g/cm3) in the x-ray absorption method. The density of liquid Ni was also determined to be 8.70 } 0.15?8.98 } 0.38 g/cm3 at 16?23 GPa and 2230?2480 K. Consequently, the temperature limit of the x-ray absorption method can be expanded from 720 to 2480 K by combining it with a laser-heated DAC in this study. en-copyright= kn-copyright= en-aut-name=TerasakiHidenori en-aut-sei=Terasaki en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KaminaHiroyuki en-aut-sei=Kamina en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KawaguchiSaori I. en-aut-sei=Kawaguchi en-aut-mei=Saori I. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KondoTadashi en-aut-sei=Kondo en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MoriokaKo en-aut-sei=Morioka en-aut-mei=Ko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TsuruokaRyo en-aut-sei=Tsuruoka en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SakuraiMoe en-aut-sei=Sakurai en-aut-mei=Moe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YonedaAkira en-aut-sei=Yoneda en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KamadaSeiji en-aut-sei=Kamada en-aut-mei=Seiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HiraoNaohisa en-aut-sei=Hirao en-aut-mei=Naohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Earth Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Earth Sciences, Okayama University kn-affil= affil-num=3 en-affil=Japan Synchrotron Radiation Research Institute, SPring-8 kn-affil= affil-num=4 en-affil=Department of Earth and Space Science, Osaka University kn-affil= affil-num=5 en-affil=Department of Earth Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Earth and Space Science, Osaka University kn-affil= affil-num=7 en-affil=Department of Earth Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Earth and Space Science, Osaka University kn-affil= affil-num=9 en-affil=AD Science Incorporation kn-affil= affil-num=10 en-affil=Japan Synchrotron Radiation Research Institute, SPring-8 kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250317 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Novel Therapeutic Algorism in Patients With Anterior Cutaneous Nerve Entrapment Syndrome en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Anterior cutaneous nerve entrapment syndrome (ACNES) is often overlooked as a cause of chronic abdominal pain. Trigger point injections (TPIs) serve as both a diagnostic and therapeutic tool. Although neurectomy is frequently chosen for patients with severe ACNES, its surgical outcomes remain unclear.
Aim: This study aims to evaluate both the short- and long-term outcomes for neurectomy and propose a novel therapeutic algorithm.
Methods: A cohort of postoperative patients presenting with ACNES between 2016 and 2023 was retrospectively evaluated. Patients received a single diagnostic TPI. When the pain subsided, an anterior neurectomy was performed using either an anterior or laparoscopic approach. Pain scores were assessed using the numeric rating scale (NRS).
Results: Among 37 patients (60% females, mean age 33.8?}?3.4?years), 29 patients (78.4%) experienced pain recurrence following initial neurectomy. Of these, 22 patients underwent repeat neurectomies, resulting in complete remission in 15 patients and no benefit in 7 patients. Long-term outcomes showed that 62.2% achieved clinical remission (NRS?=?0), whereas 8.1% reported reduced but persistent pain (NRS 1?2). Preoperative TPI effectiveness was a strong predictor of surgical success, with patients achieving post-TPI NRS (0?1) significantly more likely to attain remission (p?=?0.0074). Older age was also associated with higher remission rates (p?=?0.0476).
Conclusion: TPI is critical for predicting neurectomy success. These findings support the integration of preoperative TPI evaluation and tailored surgical strategies to optimize outcomes for patients with ACNES. en-copyright= kn-copyright= en-aut-name=KondoYoshitaka en-aut-sei=Kondo en-aut-mei=Yoshitaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KanayaNobuhiko en-aut-sei=Kanaya en-aut-mei=Nobuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KobayashiAmi en-aut-sei=Kobayashi en-aut-mei=Ami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ArakawaKyosuke en-aut-sei=Arakawa en-aut-mei=Kyosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MatsuokaYoshikazu en-aut-sei=Matsuoka en-aut-mei=Yoshikazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MimataYudai en-aut-sei=Mimata en-aut-mei=Yudai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KakiuchiYoshihiko en-aut-sei=Kakiuchi en-aut-mei=Yoshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ShigeyasuKunitoshi en-aut-sei=Shigeyasu en-aut-mei=Kunitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KurodaShinji en-aut-sei=Kuroda en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KagawaShunsuke en-aut-sei=Kagawa en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Neurology, Brigham and Women's Hospital, Harvard Medical School kn-affil= affil-num=4 en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine kn-affil= affil-num=5 en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine kn-affil= affil-num=6 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=anterior cutaneous nerve entrapment syndrome (ACNES) kn-keyword=anterior cutaneous nerve entrapment syndrome (ACNES) en-keyword=neurectomy kn-keyword=neurectomy en-keyword=trigger point injections (TPIs) kn-keyword=trigger point injections (TPIs) END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=4 article-no= start-page=283 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Cancer-related alopecia and wig acquisition: how age, sex, and treatment affect patient choices en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose This study aimed to explore the prevalence and cost of wig purchases among patients with cancer in Okayama Prefecture, Japan, and examine the relationship between wig purchases and various demographic, social, and clinical factors. The findings aim to provide insights into appearance care and support systems for patients with cancer, particularly wig subsidies.
Methods A survey was conducted between July and August 2023 among 3000 patients with cancer at 13 designated cancer care hospitals in Okayama Prefecture. Data on demographics, cancer treatment status, and wig purchase details were collected. Statistical analyses, including the Mann?Whitney U test, chi-square test, and logistic regression, were performed to identify factors significantly associated with wig purchases.
Results Among the 863 respondents, 31.4% (271 patients) reported purchasing wigs. Factors significantly associated with wig purchase included young age (odds ratio [OR]?=?1.04), female sex (OR?=?1.61), and current cancer treatment (OR?=?1.16). No significant correlation was found between wig purchase and household income, although higher-income patients tended to purchase more expensive wigs.
Conclusion The findings suggest that younger female patients with cancer and those undergoing treatment were more likely to purchase wigs, highlighting the importance of appearance care and the need for enhanced financial support for low-income patients. en-copyright= kn-copyright= en-aut-name=KatayamaHideki en-aut-sei=Katayama en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IchiharaEiki en-aut-sei=Ichihara en-aut-mei=Eiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MoritaAyako en-aut-sei=Morita en-aut-mei=Ayako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MakimotoGo en-aut-sei=Makimoto en-aut-mei=Go kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KagawaShunsuke en-aut-sei=Kagawa en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IshiiAyano en-aut-sei=Ishii en-aut-mei=Ayano kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TabataMasahiro en-aut-sei=Tabata en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Palliative and Supportive Care, Okayama University Hospital kn-affil= affil-num=2 en-affil=Center for Clinical Oncology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Allergy and Respiratory Medicine , Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Allergy and Respiratory Medicine , Okayama University Hospital kn-affil= affil-num=5 en-affil=Center for Clinical Oncology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Integrated Support Center for Patients and Self-Learning , Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Palliative and Supportive Care, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= en-keyword=Cancer kn-keyword=Cancer en-keyword=Alopecia kn-keyword=Alopecia en-keyword=Wig purchases kn-keyword=Wig purchases en-keyword=Appearance care kn-keyword=Appearance care en-keyword=Patient support kn-keyword=Patient support END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue=6 article-no= start-page=2485 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250311 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Vesicular Glutamate Transporter 3 Is Involved in Glutamatergic Signalling in Podocytes en-subtitle= kn-subtitle= en-abstract= kn-abstract=Glomerular podocytes act as a part of the filtration barrier in the kidney. The activity of this filter is regulated by ionotropic and metabotropic glutamate receptors. Adjacent podocytes can potentially release glutamate into the intercellular space; however, little is known about how podocytes release glutamate. Here, we demonstrated vesicular glutamate transporter 3 (VGLUT3)-dependent glutamate release from podocytes. Immunofluorescence analysis revealed that rat glomerular podocytes and an immortal mouse podocyte cell line (MPC) express VGLUT1 and VGLUT3. Consistent with this finding, quantitative RT-PCR revealed the expression of VGLUT1 and VGLUT3 mRNA in undifferentiated and differentiated MPCs. In addition, the exocytotic proteins vesicle-associated membrane protein 2, synapsin 1, and synaptophysin 1 were present in punctate patterns and colocalized with VGLUT3 in MPCs. Interestingly, approximately 30% of VGLUT3 colocalized with VGLUT1. By immunoelectron microscopy, VGLUT3 was often observed around clear vesicle-like structures in differentiated MPCs. Differentiated MPCs released glutamate following depolarization with high potassium levels and after stimulation with the muscarinic agonist pilocarpine. The depletion of VGLUT3 in MPCs by RNA interference reduced depolarization-dependent glutamate release. These results strongly suggest that VGLUT3 is involved in glutamatergic signalling in podocytes and may be a new drug target for various kidney diseases. en-copyright= kn-copyright= en-aut-name=NishiiNaoko en-aut-sei=Nishii en-aut-mei=Naoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawaiTomoko en-aut-sei=Kawai en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YasuokaHiroki en-aut-sei=Yasuoka en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AbeTadashi en-aut-sei=Abe en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TatsumiNanami en-aut-sei=Tatsumi en-aut-mei=Nanami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HaradaYuika en-aut-sei=Harada en-aut-mei=Yuika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MiyajiTakaaki en-aut-sei=Miyaji en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=LiShunai en-aut-sei=Li en-aut-mei=Shunai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TsukanoMoemi en-aut-sei=Tsukano en-aut-mei=Moemi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=WatanabeMasami en-aut-sei=Watanabe en-aut-mei=Masami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=OgawaDaisuke en-aut-sei=Ogawa en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=TakeiKohji en-aut-sei=Takei en-aut-mei=Kohji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=YamadaHiroshi en-aut-sei=Yamada en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Cell Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Genomics and Proteomics, Advanced Science Research Center, Okayama University kn-affil= affil-num=7 en-affil=Department of Genomics and Proteomics, Advanced Science Research Center, Okayama University kn-affil= affil-num=8 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil= affil-num=9 en-affil=Central Research Laboratory, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil= affil-num=11 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=13 en-affil=Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=14 en-affil=Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=VGLUT3 kn-keyword=VGLUT3 en-keyword=glutamate kn-keyword=glutamate en-keyword=podocyte kn-keyword=podocyte en-keyword=glutamatergic transmission kn-keyword=glutamatergic transmission END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=1547222 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250311 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways en-subtitle= kn-subtitle= en-abstract= kn-abstract=Aims: Cathepsins are essential lysosomal enzymes that maintain organismal homeostasis by degrading extracellular substrates. The inflammatory cytokine interleukin-6 (IL-6) increases the production of cathepsins through the caveolin-1 (Cav-1) and c-Jun N-terminal kinase (JNK) signaling pathways, which have been implicated in the destruction of periodontal tissue. This study investigated the effect of the IL-6/soluble IL-6 receptor (sIL-6R) complex on the extracellular secretion of cathepsins in human gingival fibroblasts (HGFs) and examined the function of extracellularly secreted cathepsins B and L under acidic culture conditions in vitro.
Methods: HGFs were isolated from healthy volunteer donors. The expression of Cav-1 was suppressed via transfection with small interfering RNA (siRNA) targeting Cav-1. The expression levels of cathepsins B and L induced by extracellular IL-6/sIL-6R were measured using western blotting and enzyme-linked immunosorbent assay. Extracellular cathepsin activity following IL-6/sIL-6R stimulation was assessed using a methylcoumarylamide substrate in a fluorescence-based assay. IL-6/sIL-6R-induced expression of cathepsins B and L in HGFs was quantified under inhibitory conditions for extracellular signal-regulated kinase (ERK) 1/2 and/or JNK signaling, both of which are transduction pathways activated by IL-6/sIL-6R. This quantification was also performed in HGFs with suppressed Cav-1 expression using western blotting.
Results: Cathepsins B and L were secreted in their precursor forms from HGFs, with significantly elevated protein levels observed at 24, 48, and 72 h post-IL-6/sIL-6R stimulation. Under acidic culture conditions, cathepsin B activity increased at 48 and 72 h. Cav-1 suppression inhibited the secretion of cathepsin B regardless of IL-6/sIL-6R stimulation, whereas the secretion of cathepsin L was reduced only after 48 h of IL-6/sIL-6R stimulation. Inhibition of ERK1/2 and JNK pathways decreased the secretion of cathepsin B after 48 h of IL-6/sIL-6R stimulation, and JNK inhibition reduced the secretion of cathepsin L under similar conditions.
Conclusion: IL-6/sIL-6R stimulation increased the extracellular secretion of cathepsin B and L precursors in HGFs, and these precursors became activated under acidic conditions. Cav-1 and ERK1/2 are involved in regulating the secretion of cathepsin B precursors. en-copyright= kn-copyright= en-aut-name=GotoAyaka en-aut-sei=Goto en-aut-mei=Ayaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OmoriKazuhiro en-aut-sei=Omori en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=Yamaguchi-TomikawaTomoko en-aut-sei=Yamaguchi-Tomikawa en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KobayashiHiroya en-aut-sei=Kobayashi en-aut-mei=Hiroya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=Shinoda-ItoYuki en-aut-sei=Shinoda-Ito en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HiraiKimito en-aut-sei=Hirai en-aut-mei=Kimito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IkedaAtsushi en-aut-sei=Ikeda en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakashibaShogo en-aut-sei=Takashiba en-aut-mei=Shogo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Periodontics & Endodontics, Division of Dentistry, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=cathepsin B kn-keyword=cathepsin B en-keyword=cathepsin L kn-keyword=cathepsin L en-keyword=human gingival fibroblast kn-keyword=human gingival fibroblast en-keyword=interleukin-6 kn-keyword=interleukin-6 en-keyword=caveolin kn-keyword=caveolin END start-ver=1.4 cd-journal=joma no-vol=301 cd-vols= no-issue=4 article-no= start-page=108334 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Roles of basic amino acid residues in substrate binding and transport of the light-driven anion pump Synechocystis halorhodopsin (SyHR) en-subtitle= kn-subtitle= en-abstract= kn-abstract=Microbial rhodopsins are photoreceptive seventransmembrane a-helical proteins, many of which function as ion transporters, primarily for small monovalent ions such as Na+, K+, Cl-, Br-, and I-. Synechocystis halorhodopsin (SyHR), identified from the cyanobacterium Synechocystis sp. PCC 7509, uniquely transports the polyatomic divalent SO42- inward, in addition to monovalent anions (Cl- and Br-). In this study, we conducted alanine-scanning mutagenesis on twelve basic amino acid residues to investigate the anion transport mechanism of SyHR. We quantitatively evaluated the Cl-and SO42- transport activities of the WT SyHR and its mutants. The results showed a strong correlation between the Cl-and SO42- transport activities among them (R = 0.94), suggesting a shared pathway for both anions. Notably, the R71A mutation selectively abolished SO42- transport activity while maintaining Cl- transport, whereas the H167A mutation significantly impaired both Cl-and SO42- transport. Furthermore, spectroscopic analysis revealed that the R71A mutant lost its ability to bind SO42- due to the absence of a positive charge, while the H167A mutant failed to accumulate the O intermediate during the photoreaction cycle (photocycle) due to reduced hydrophilicity. Additionally, computational analysis revealed the SO42- binding modes and clarified the roles of residues involved in its binding around the retinal chromophore. Based on these findings and previous structural information, we propose that the positive charge and hydrophilicity of Arg71 and His167 are crucial for the formation of the characteristic initial and transient anion-binding site of SyHR, enabling its unique ability to bind and transport both Cl-and SO42-. en-copyright= kn-copyright= en-aut-name=NakamaMasaki en-aut-sei=Nakama en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NojiTomoyasu en-aut-sei=Noji en-aut-mei=Tomoyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KojimaKeiichi en-aut-sei=Kojima en-aut-mei=Keiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YoshizawaSusumu en-aut-sei=Yoshizawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IshikitaHiroshi en-aut-sei=Ishikita en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SudoYuki en-aut-sei=Sudo en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Applied Chemistry, The University of Tokyo kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Atmosphere and Ocean Research Institute, The University of Tokyo kn-affil= affil-num=5 en-affil=Department of Applied Chemistry, The University of Tokyo kn-affil= affil-num=6 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=microbial rhodopsin kn-keyword=microbial rhodopsin en-keyword=anion transport kn-keyword=anion transport en-keyword=retinal kn-keyword=retinal en-keyword=membrane protein kn-keyword=membrane protein en-keyword=photobiology kn-keyword=photobiology END start-ver=1.4 cd-journal=joma no-vol=17 cd-vols= no-issue=3 article-no= start-page=124 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250311 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Facial Privacy Protection with Dynamic Multi-User Access Control for Online Photo Platforms en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the digital age, sharing moments through photos has become a daily habit. However, every face captured in these photos is vulnerable to unauthorized identification and potential misuse through AI-powered synthetic content generation. Previously, we introduced SnapSafe, a secure system for enabling selective image privacy focusing on facial regions for single-party scenarios. Recognizing that group photos with multiple subjects are a more common scenario, we extend SnapSafe to support multi-user facial privacy protection with dynamic access control designed for online photo platforms. Our approach introduces key splitting for access control, an owner-centric permission system for granting and revoking access to facial regions, and a request-based mechanism allowing subjects to initiate access permissions. These features ensure that facial regions remain protected while maintaining the visibility of non-facial content for general viewing. To ensure reproducibility and isolation, we implemented our solution using Docker containers. Our experimental assessment covered diverse scenarios, categorized as "Single", "Small", "Medium", and "Large", based on the number of faces in the photos. The results demonstrate the system's effectiveness across all test scenarios, consistently performing face encryption operations in under 350 ms and achieving average face decryption times below 286 ms across various group sizes. The key-splitting operations maintained a 100% success rate across all group configurations, while revocation operations were executed efficiently with server processing times remaining under 16 ms. These results validate the system's capability in managing facial privacy while maintaining practical usability in online photo sharing contexts. en-copyright= kn-copyright= en-aut-name=SantosoAndri en-aut-sei=Santoso en-aut-mei=Andri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HudaSamsul en-aut-sei=Huda en-aut-mei=Samsul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KoderaYuta en-aut-sei=Kodera en-aut-mei=Yuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NogamiYasuyuki en-aut-sei=Nogami en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Green Innovation Center, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=facial privacy protection kn-keyword=facial privacy protection en-keyword=selective facial encryption kn-keyword=selective facial encryption en-keyword=multi-user access control kn-keyword=multi-user access control en-keyword=deep-learning applications kn-keyword=deep-learning applications en-keyword=online photo platform kn-keyword=online photo platform END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue=6 article-no= start-page=2713 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Involvement of a Novel Variant of FGFR1 Detected in an Adult Patient with Kallmann Syndrome in Regulation of Gonadal Steroidogenesis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Fibroblast growth factor receptor 1 (FGFR1), also known as KAL2, is a tyrosine kinase receptor, and variants of FGFR1 have been detected in patients with Kallmann syndrome (KS), which is a congenital developmental disorder characterized by central hypogonadism and anosmia. Herein, we report an adult case of KS with a novel variant of FGFR1. A middle-aged male was referred for a compression fracture of a lumbar vertebra. It was shown that he had severe osteoporosis, anosmia, gynecomastia, and a past history of operations for cryptorchidism. Endocrine workup using pituitary and gonadal stimulation tests revealed the presence of both primary and central hypogonadism. Genetic testing revealed a novel variant of FGFR1 (c.2197_2199dup, p.Met733dup). To identify the pathogenicity of the novel variant and the clinical significance for the gonads, we investigated the effects of the FGFR1 variant on the downstream signaling of FGFR1 and gonadal steroidogenesis by using human steroidogenic granulosa cells. It was revealed that the transfection of the variant gene significantly impaired FGFR1 signaling, detected through the downregulation of SPRY2, compared with that of the case of the forced expression of wild-type FGFR1, and that the existence of the variant gene apparently altered the expression of key steroidogenic factors, including StAR and aromatase, in the gonad. The results suggested that the novel variant of FGFR1 detected in the patient with KS was linked to the impairment of FGFR1 signaling, as well as the alteration of gonadal steroidogenesis, leading to the pathogenesis of latent primary hypogonadism. en-copyright= kn-copyright= en-aut-name=SoejimaYoshiaki en-aut-sei=Soejima en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OtsukaYuki en-aut-sei=Otsuka en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KawaguchiMarina en-aut-sei=Kawaguchi en-aut-mei=Marina kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OguniKohei en-aut-sei=Oguni en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamamotoKoichiro en-aut-sei=Yamamoto en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakanoYasuhiro en-aut-sei=Nakano en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YasudaMiho en-aut-sei=Yasuda en-aut-mei=Miho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TokumasuKazuki en-aut-sei=Tokumasu en-aut-mei=Kazuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=UedaKeigo en-aut-sei=Ueda en-aut-mei=Keigo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HasegawaKosei en-aut-sei=Hasegawa en-aut-mei=Kosei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IwataNahoko en-aut-sei=Iwata en-aut-mei=Nahoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=11 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=fibroblast growth factor receptor 1 (FGFR1) kn-keyword=fibroblast growth factor receptor 1 (FGFR1) en-keyword=gynecomastia kn-keyword=gynecomastia en-keyword=Kallmann syndrome (KS) kn-keyword=Kallmann syndrome (KS) en-keyword=osteoporosis and steroidogenesis kn-keyword=osteoporosis and steroidogenesis END start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue= article-no= start-page=670 end-page=679 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Photochemically assisted synthesis of phenacenes fluorinated at the terminal benzene rings and their electronic spectra en-subtitle= kn-subtitle= en-abstract= kn-abstract=[n]Phenacenes ([n] = 5-7), octafluorinated at the terminal benzene rings (F8-phenacenes: F8PIC, F8FUL, and F87PHEN), were photochemically synthesized, and their electronic spectra were investigated to reveal the effects of the fluorination on the electronic features of phenacene molecules. F8-Phenacenes were conveniently synthesized by the Mallory photoreaction of the corresponding fluorinated diarylethenes as the key step. Upon fluorination on the phenacene cores, the absorption and fluorescence bands of the F8-phenacenes in CHCl3 systematically red-shifted by ca. 3-5 nm compared to those of the corresponding parent phenacenes. The vibrational progressions of the absorption and fluorescence bands were little affected by the fluorination in the solution phase. In the solid state, the absorption band of F8-phenacenes appeared in the similar wavelength region for the corresponding parent phenacenes whereas their fluorescence bands markedly red-shifted and broadened. These observations suggest that the intermolecular interactions of excited-state F8-phenacene molecules are significantly different from those of the corresponding parent molecules, most likely due to different crystalline packing motifs. en-copyright= kn-copyright= en-aut-name=IshiiYuuki en-aut-sei=Ishii en-aut-mei=Yuuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamajiMinoru en-aut-sei=Yamaji en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TaniFumito en-aut-sei=Tani en-aut-mei=Fumito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GotoKenta en-aut-sei=Goto en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KubozonoYoshihiro en-aut-sei=Kubozono en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Molecular Science, Graduate School of Science and Engineering, Gunma University kn-affil= affil-num=3 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=4 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=5 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=fluorescence kn-keyword=fluorescence en-keyword=fluorinated aromatics kn-keyword=fluorinated aromatics en-keyword=phenacene kn-keyword=phenacene en-keyword=photoreaction kn-keyword=photoreaction END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=1537615 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250311 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=PARylation-mediated post-transcriptional modifications in cancer immunity and immunotherapy en-subtitle= kn-subtitle= en-abstract= kn-abstract=Poly-ADP-ribosylation (PARylation) is a post-translational modification in which ADP-ribose is added to substrate proteins. PARylation is mediated by a superfamily of ADP-ribosyl transferases known as PARPs and influences a wide range of cellular functions, including genome integrity maintenance, and the regulation of proliferation and differentiation. We and others have recently reported that PARylation of SH3 domain-binding protein 2 (3BP2) plays a role in bone metabolism, immune system regulation, and cytokine production. Additionally, PARylation has recently gained attention as a target for cancer treatment. In this review, we provide an overview of PARylation, its involvement in several signaling pathways related to cancer immunity, and the potential of combination therapies with PARP inhibitors and immune checkpoint inhibitors. en-copyright= kn-copyright= en-aut-name=MatsumotoKazuya en-aut-sei=Matsumoto en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsumotoYoshinori en-aut-sei=Matsumoto en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=PARylation kn-keyword=PARylation en-keyword=cancer kn-keyword=cancer en-keyword=post-transcriptional regulation kn-keyword=post-transcriptional regulation en-keyword=ubiquitylation kn-keyword=ubiquitylation en-keyword=immune system kn-keyword=immune system END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=6 article-no= start-page=668 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Robustness of Machine Learning Predictions for Determining Whether Deep Inspiration Breath-Hold Is Required in Breast Cancer Radiation Therapy en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background/Objectives: Deep inspiration breath-hold (DIBH) is a commonly used technique to reduce the mean heart dose (MHD), which is critical for minimizing late cardiac side effects in breast cancer patients undergoing radiation therapy (RT). Although previous studies have explored the potential of machine learning (ML) to predict which patients might benefit from DIBH, none have rigorously assessed ML model performance across various MHD thresholds and parameter settings. This study aims to evaluate the robustness of ML models in predicting the need for DIBH across different clinical scenarios. Methods: Using data from 207 breast cancer patients treated with RT, we developed and tested ML models at three MHD cut-off values (240, 270, and 300 cGy), considering variations in the number of independent variables (three vs. six) and folds in the cross-validation (three, four, and five). Robustness was defined as achieving high F2 scores and low instability in predictive performance. Results: Our findings indicate that the decision tree (DT) model demonstrated consistently high robustness at 240 and 270 cGy, while the random forest model performed optimally at 300 cGy. At 240 cGy, a threshold critical to minimize late cardiac risks, the DT model exhibited stable predictive power, reducing the risk of overestimating DIBH necessity. Conclusions: These results suggest that the DT model, particularly at lower MHD thresholds, may be the most reliable for clinical applications. By providing a tool for targeted DIBH implementation, this model has the potential to enhance patient-specific treatment planning and improve clinical outcomes in RT. en-copyright= kn-copyright= en-aut-name=Al-HammadWlla E. en-aut-sei=Al-Hammad en-aut-mei=Wlla E. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KurodaMasahiro en-aut-sei=Kuroda en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=Al JamalJamal, Ghaida en-aut-sei=Al Jamal en-aut-mei=Jamal, Ghaida kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FujikuraMamiko en-aut-sei=Fujikura en-aut-mei=Mamiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KamizakiRyo en-aut-sei=Kamizaki en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KurodaKazuhiro en-aut-sei=Kuroda en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YoshidaSuzuka en-aut-sei=Yoshida en-aut-mei=Suzuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NakamuraYoshihide en-aut-sei=Nakamura en-aut-mei=Yoshihide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OitaMasataka en-aut-sei=Oita en-aut-mei=Masataka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TanabeYoshinori en-aut-sei=Tanabe en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=SugimotoKohei en-aut-sei=Sugimoto en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=SugiantoIrfan en-aut-sei=Sugianto en-aut-mei=Irfan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=BarhamMajd en-aut-sei=Barham en-aut-mei=Majd kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=TekikiNouha en-aut-sei=Tekiki en-aut-mei=Nouha kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=HisatomiMiki en-aut-sei=Hisatomi en-aut-mei=Miki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=AsaumiJunichi en-aut-sei=Asaumi en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= affil-num=1 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Oral Medicine and Oral Surgery, Faculty of Dentistry, Jordan University of Science and Technology kn-affil= affil-num=4 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=6 en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Graduate School of Interdisciplinary Sciences and Engineering in Health Systems, Okayama University kn-affil= affil-num=10 en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=11 en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Oral Radiology, Faculty of Dentistry, Hasanuddin University kn-affil= affil-num=13 en-affil=Department of Dentistry and Dental Surgery, College of Medicine and Health Sciences, An-Najah National University kn-affil= affil-num=14 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=15 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=16 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=breast cancer kn-keyword=breast cancer en-keyword=radiation therapy kn-keyword=radiation therapy en-keyword=heart dose kn-keyword=heart dose en-keyword=cut-off value kn-keyword=cut-off value en-keyword=machine learning kn-keyword=machine learning en-keyword=robustness kn-keyword=robustness en-keyword=instability kn-keyword=instability en-keyword=F2 score kn-keyword=F2 score en-keyword=deep inspiration breath-hold technique kn-keyword=deep inspiration breath-hold technique en-keyword=computed tomography kn-keyword=computed tomography END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=6 article-no= start-page=790 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Improving Diagnostic Performance for Head and Neck Tumors with Simple Diffusion Kurtosis Imaging and Machine Learning Bi-Parameter Analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background/Objectives: Mean kurtosis (MK) values in simple diffusion kurtosis imaging (SDI)-a type of diffusion kurtosis imaging (DKI)-have been reported to be useful in the diagnosis of head and neck malignancies, for which pre-processing with smoothing filters has been reported to improve the diagnostic accuracy. Multi-parameter analysis using DKI in combination with other image types has recently been reported to improve the diagnostic performance. The purpose of this study was to evaluate the usefulness of machine learning (ML)-based multi-parameter analysis using the MK and apparent diffusion coefficient (ADC) values-which can be acquired simultaneously through SDI-for the differential diagnosis of benign and malignant head and neck tumors, which is important for determining the treatment strategy, as well as examining the usefulness of filter pre-processing. Methods: A total of 32 pathologically diagnosed head and neck tumors were included in the study, and a Gaussian filter was used for image pre-processing. MK and ADC values were extracted from pixels within the tumor area and used as explanatory variables. Five ML algorithms were used to create models for the prediction of tumor status (benign or malignant), which were evaluated through ROC analysis. Results: Bi-parameter analysis with gradient boosting achieved the best diagnostic performance, with an AUC of 0.81. Conclusions: The usefulness of bi-parameter analysis with ML methods for the differential diagnosis of benign and malignant head and neck tumors using SDI data were demonstrated. en-copyright= kn-copyright= en-aut-name=YoshidaSuzuka en-aut-sei=Yoshida en-aut-mei=Suzuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KurodaMasahiro en-aut-sei=Kuroda en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakamuraYoshihide en-aut-sei=Nakamura en-aut-mei=Yoshihide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FukumuraYuka en-aut-sei=Fukumura en-aut-mei=Yuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakamitsuYuki en-aut-sei=Nakamitsu en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=Al-HammadWlla E. en-aut-sei=Al-Hammad en-aut-mei=Wlla E. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KurodaKazuhiro en-aut-sei=Kuroda en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ShimizuYudai en-aut-sei=Shimizu en-aut-mei=Yudai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TanabeYoshinori en-aut-sei=Tanabe en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OitaMasataka en-aut-sei=Oita en-aut-mei=Masataka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=SugiantoIrfan en-aut-sei=Sugianto en-aut-mei=Irfan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=BarhamMajd en-aut-sei=Barham en-aut-mei=Majd kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=TekikiNouha en-aut-sei=Tekiki en-aut-mei=Nouha kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KamaruddinNurul N. en-aut-sei=Kamaruddin en-aut-mei=Nurul N. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=HisatomiMiki en-aut-sei=Hisatomi en-aut-mei=Miki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=YanagiYoshinobu en-aut-sei=Yanagi en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=AsaumiJunichi en-aut-sei=Asaumi en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= affil-num=1 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=10 en-affil=Graduate School of Interdisciplinary Sciences and Engineering in Health Systems, Okayama University kn-affil= affil-num=11 en-affil=Department of Oral Radiology, Faculty of Dentistry, Hasanuddin University kn-affil= affil-num=12 en-affil=Department of Dentistry and Dental Surgery, College of Medicine and Health Sciences, An-Najah National University kn-affil= affil-num=13 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=14 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=15 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=16 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=17 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=head and neck tumors kn-keyword=head and neck tumors en-keyword=mean kurtosis kn-keyword=mean kurtosis en-keyword=simple diffusion kurtosis imaging kn-keyword=simple diffusion kurtosis imaging en-keyword=magnetic resonance imaging kn-keyword=magnetic resonance imaging en-keyword=apparent diffusion coefficient value kn-keyword=apparent diffusion coefficient value en-keyword=diffusion kurtosis imaging kn-keyword=diffusion kurtosis imaging en-keyword=machine learning kn-keyword=machine learning en-keyword=bi-parameter analysis kn-keyword=bi-parameter analysis en-keyword=gradient boosting kn-keyword=gradient boosting en-keyword=differential diagnosis of benign and malignant kn-keyword=differential diagnosis of benign and malignant END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue=1 article-no= start-page=e70053 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Association of blood carboxyhemoglobin levels with mortality and neurological outcomes in out-of-hospital cardiac arrest en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Carbon monoxide (CO), produced endogenously by heme oxygenase-1, plays a crucial role in the immune system by mitigating cellular damage under stress. However, the significance of carboxyhemoglobin (COHb) levels after out-of-hospital cardiac arrest (OHCA) is not well understood. This study aimed to explore the association between COHb levels at hospital arrival and within the first 24 h post-arrival with 30-day mortality and neurological outcomes in patients who experienced OHCA.
Methods: This single-center, retrospective study analyzed data from adult patients who experienced OHCA seen at Okayama University Hospital from 2019 to 2023. The patients were assigned to one of two study groups based on COHb levels (0.0% or >= 0.1%) upon hospital arrival. The primary outcome was 30-day mortality.
Results: Among the 560 eligible patients who experienced OHCA, 284 (50.7%) were in the COHb 0.0% group and 276 (49.3%) were in the COHb >= 0.1% group. The 30-day mortality was significantly higher in the COHb 0.0% group compared to the COHb >= 0.1% group (264 [92.9%] vs. 233 [84.4%]). Multivariable logistic regression showed that the COHb 0.0% group was associated with 30-day mortality (adjusted ORs: 2.24, 95% CIs: 1.10-4.56). Non-survivors at 30 days who were admitted to the intensive care unit had lower COHb levels at hospital arrival (0.0% vs. 0.2%) and lower mean COHb levels during the first 24 h post-arrival (0.7% vs. 0.9%) compared to survivors.
Conclusions: COHb levels of 0.0% were linked to worse outcomes in patients experiencing OHCA, warranting further research on the prognostic implications of COHb in this context. en-copyright= kn-copyright= en-aut-name=HongoTakashi en-aut-sei=Hongo en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YumotoTetsuya en-aut-sei=Yumoto en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NaitoHiromichi en-aut-sei=Naito en-aut-mei=Hiromichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HiraokaTomohiro en-aut-sei=Hiraoka en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MurakamiYuya en-aut-sei=Murakami en-aut-mei=Yuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ObaraTakafumi en-aut-sei=Obara en-aut-mei=Takafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NojimaTsuyoshi en-aut-sei=Nojima en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=AokageToshiyuki en-aut-sei=Aokage en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NakaoAtsunori en-aut-sei=Nakao en-aut-mei=Atsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=brain injury kn-keyword=brain injury en-keyword=carbon monoxide kn-keyword=carbon monoxide en-keyword=carboxyhemoglobin kn-keyword=carboxyhemoglobin en-keyword=cardiac arrest kn-keyword=cardiac arrest en-keyword=resuscitation kn-keyword=resuscitation END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=6 article-no= start-page=619 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250313 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of Trehalose on Halitosis: A Randomized Cross-Over Clinical Trial en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background/Objectives: Halitosis is a condition characterized by an unpleasant malodor. Intra-oral halitosis is caused by volatile sulfur compounds (VSCs) and can be associated with oral dryness. Trehalose is one of the materials used to relieve oral dryness. The aim of the present study was to investigate the effect of trehalose on halitosis. Methods: This prospective, double-blinded, placebo-controlled, cross-over study enrolled volunteers from Okayama University Hospital. The participants were randomly divided into two groups, with one group receiving trehalose (a 10% trehalose solution) and the other receiving a placebo (distilled water) in a 1:1 allocation. The primary study outcome was the subjective organoleptic test. The secondary outcomes were the concentrations of the VSCs, which were measured using a portable gas chromatography device, and the oral moisture status, which was measured using an oral moisture meter. The planned sample size was 10 participants based on the previous study. Results: The final intention-to-treat analysis was performed using the data from 9 participants. After applying 10% trehalose as an oral spray, the organoleptic score decreased in a time-dependent manner. However, no significant differences were seen between the trehalose and placebo groups. In terms of secondary outcomes, the oral moisture levels increased immediately after the trehalose spray application, and significant differences in the amount of change from the baseline were seen between the trehalose and placebo groups (p = 0.047). No significant differences were seen in any of the other variables (p > 0.05). Conclusions: We could not identify any positive effects on halitosis from a one-time 10% trehalose application as an oral spray in this prospective, double-blinded, placebo-controlled, cross-over study. However, the trehalose application immediately improved the oral moisture levels and was useful for treating oral dryness. en-copyright= kn-copyright= en-aut-name=MiyaiHisataka en-aut-sei=Miyai en-aut-mei=Hisataka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TomofujiTakaaki en-aut-sei=Tomofuji en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MizunoHirofumi en-aut-sei=Mizuno en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoritaManabu en-aut-sei=Morita en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakaharaMomoko en-aut-sei=Nakahara en-aut-mei=Momoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KataokaKota en-aut-sei=Kataoka en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SumitaIchiro en-aut-sei=Sumita en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=UchidaYurika en-aut-sei=Uchida en-aut-mei=Yurika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ToyamaNaoki en-aut-sei=Toyama en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YokoiAya en-aut-sei=Yokoi en-aut-mei=Aya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=Yamanaka-KohnoReiko en-aut-sei=Yamanaka-Kohno en-aut-mei=Reiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=TakeuchiNoriko en-aut-sei=Takeuchi en-aut-mei=Noriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=MaruyamaTakayuki en-aut-sei=Maruyama en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=EkuniDaisuke en-aut-sei=Ekuni en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Community Oral Health, School of Dentistry, Asahi University kn-affil= affil-num=3 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Oral Health Sciences, Faculty of Health Care Sciences, Takarazuka University of Medical and Health Care kn-affil= affil-num=5 en-affil=Department of Preventive Dentistry, Division of Dentistry, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Preventive Dentistry, Division of Dentistry, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Preventive Dentistry, Division of Dentistry, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Preventive Dentistry, Division of Dentistry, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Preventive Dentistry, Division of Dentistry, Okayama University Hospital kn-affil= affil-num=12 en-affil=Department of Preventive Dentistry, Division of Dentistry, Okayama University Hospital kn-affil= affil-num=13 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=14 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=halitosis kn-keyword=halitosis en-keyword=trehalose kn-keyword=trehalose en-keyword=oral dryness kn-keyword=oral dryness en-keyword=cross-over study kn-keyword=cross-over study en-keyword=randomized trial kn-keyword=randomized trial END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue= article-no= start-page=101 end-page=112 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=19891115 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Some Sketches of Social Networks in Canberra kn-title=ƒLƒƒƒ“ƒxƒ‰‚̎Љï“Iƒlƒbƒgƒ[ƒN‚ɂ‚¢‚Ä \\ŽQ—^ŠÏŽ@‚Ì‹L˜^\\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NOBEMASAO en-aut-sei=NOBE en-aut-mei=MASAO kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=83 cd-vols= no-issue= article-no= start-page=155 end-page=164 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=19900315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Stages of Development in Canberra\PART I kn-title=ƒLƒƒƒ“ƒxƒ‰‚É‚¨‚¯‚éŠJ”­‚Ì”’iŠKi‡Tj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NOBEMASAO en-aut-sei=NOBE en-aut-mei=MASAO kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=84 cd-vols= no-issue= article-no= start-page=165 end-page=177 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=19900716 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Stages of Development in Canberra\Part II kn-title=ƒLƒƒƒ“ƒxƒ‰‚É‚¨‚¯‚éŠJ”­‚Ì”’iŠKi‡Uj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NOBEMASAO en-aut-sei=NOBE en-aut-mei=MASAO kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue= article-no= start-page=63 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=19910715 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Daily Social Support among Canberra Residents kn-title=“úí¶Šˆ‚É‚¨‚¯‚鉇•Šó‹s“® \ƒLƒƒƒ“ƒxƒ‰‚ÌŽ–—á\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@This paper reports a study that investigated perceived sources of daily support. To gather empirical evidence, a sample survey of women in four study areas of Canberra was conducted in 1986-1987. Three hundred and ninety-four women who were under 55 years of age and who were married or in a de facto relationship were interviewed. They responded to six hypothetical difficult situations by identifying the first source from which they would seek support. Analysis of the data has revealed the following ;
@(1) When respondents had their relatives in Canberra, they regarded their relatives as the chief source of daily support. However, there were many residents without local relatives in Canberra. For such respondents, their relatives were not so helpful in daily support. Incidentally, workmates were thought of as much less important providers of support than relatives, neighbours or friends.
@(2) Social networks were differentiated in that respondents tended to depend on types of people appropriate to individual difficult situations.
@(3) Dependable friends and workmates tended to live closer than dependable relatives.
@(4) Dependable relatives were usually limited to immediate family, such as parents (-in-law), brothers (-in-law) or sisters (-in-law). en-copyright= kn-copyright= en-aut-name=NOBEMASAO en-aut-sei=NOBE en-aut-mei=MASAO kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue= article-no= start-page=11 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=19911115 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Variations of Residential Groups in Okayama City, Japan kn-title=’n•û“sŽs‚É‚¨‚¯‚é’¬“à‰ï‚Ì—ÞŒ^ \\‰ªŽRŽs‚ÌŽ–—á\\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NOBEMASAO en-aut-sei=NOBE en-aut-mei=MASAO kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue= article-no= start-page=7 end-page=34 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=19920316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The First Report on the Changing Rural Community Survey\Part 1 kn-title=u¬Z‰»”_‘º’²¸v‘æ‚PŽŸ•ñ‘(1) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NOBEMASAO en-aut-sei=NOBE en-aut-mei=MASAO kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=90 cd-vols= no-issue= article-no= start-page=9 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=19920715 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The First Report on the Changing Rural Community Survey\\Part II kn-title=u¬Z‰»”_‘º’²¸v‘æ‚PŽŸ•ñ‘i‡Uj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NOBEMASAO en-aut-sei=NOBE en-aut-mei=MASAO kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=91 cd-vols= no-issue= article-no= start-page=9 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=19921116 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Occupational Change in Australia 1961-86 kn-title=ƒI[ƒXƒgƒ‰ƒŠƒA‚É‚¨‚¯‚éE‹Æ\‘¢‚Ì–¨•ªÍ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NOBEMASAO en-aut-sei=NOBE en-aut-mei=MASAO kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=92 cd-vols= no-issue= article-no= start-page=9 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Some Features of Canberra@\\Part I kn-title=ƒLƒƒƒ“ƒxƒ‰‚ÌŠTà(1) en-subtitle= kn-subtitle= en-abstract= 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kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Social Studies Education, Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆçŠw•”ŽÐ‰ï‰È‹³ˆçuÀ en-keyword=ƒp[ƒ\ƒiƒ‹Eƒlƒbƒgƒ[ƒN kn-keyword=ƒp[ƒ\ƒiƒ‹Eƒlƒbƒgƒ[ƒN en-keyword=‚—î—« kn-keyword=‚—î—« en-keyword=’n•û¬“sŽs kn-keyword=’n•û¬“sŽs en-keyword=‰ºˆÊ•¶‰»—˜_ kn-keyword=‰ºˆÊ•¶‰»—˜_ END start-ver=1.4 cd-journal=joma no-vol=17 cd-vols= no-issue=3 article-no= start-page=e81476 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Natural Course From Primary Intraocular Lymphoma to Brain Lymphoma in Four Years According to Patient's Choice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Primary intraocular lymphoma or vitreoretinal lymphoma is a rare entity of diffuse large B-cell lymphoma that presents vitreous opacity and retinal and choroidal infiltration. Primary central nervous system lymphoma would occur previously, later, or concurrently with respect to primary intraocular lymphoma. This study reported a 72-year-old patient with a pathological diagnosis of primary intraocular lymphoma who developed central nervous system lymphoma four years later in the course of no treatment. She presented with a four-year history of blurred vision in both eyes after cataract surgeries. Three weeks previously, she underwent a vitrectomy in the left eye at a clinic, and measurements of the vitreous fluid showed a high level of interleukin-10 at 5739 pg/mL, in contrast with interleukin-6 at 142 pg/mL. Cytology of the vitreous fluid was class III on the Papanicolaou classification. Head magnetic resonance imaging detected nothing abnormal. She underwent vitrectomy in the right eye as a diagnostic procedure to show large cells in the vitreous which were positive for CD20 and Ki-67 and negative for CD3, leading to a pathological diagnosis of large B-cell lymphoma. Prophylactic chemotherapy with high-dose methotrexate was recommended as a therapeutic option, but she chose observation since she did not have any eye or systemic symptoms. In the follow-up every three months by an oncologist and an ophthalmologist, she did not have any symptoms, and serum levels of soluble interleukin-2 receptor were in the normal range at each visit. She was well for four years until the age of 76 years when she fell and hit her head, and an emergency head computed tomography scan showed a mass in the left occipital lobe. Magnetic resonance imaging demonstrated a well-defined circular mass in the left occipital lobe with a hyperintense signal in the T2-weighted fluid-attenuated inversion recovery (FLAIR) image and diffusion-weighted image. Fluorodeoxyglucose positron emission tomography showed no abnormal uptake systemically, except for the left occipital lesion. She underwent a brain biopsy by craniotomy to pathologically prove diffuse large B-cell lymphoma. She was recommended to receive first-line chemotherapy as the standard treatment but chose observation with no treatment and died of brain lymphoma nine months later. This case happened to illustrate a natural course of primary intraocular lymphoma which proceeded to central nervous system lymphoma four years later. en-copyright= kn-copyright= en-aut-name=MatsuoToshihiko en-aut-sei=Matsuo en-aut-mei=Toshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IshidaJoji en-aut-sei=Ishida en-aut-mei=Joji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KondoShotaro en-aut-sei=Kondo en-aut-mei=Shotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MatsuokaKen-ichi en-aut-sei=Matsuoka en-aut-mei=Ken-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Ophthalmology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=2 en-affil=Department of Pathology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurological Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Internal Medicine, Kurashiki Municipal Hospital kn-affil= affil-num=5 en-affil=Department of Hematology and Oncology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=brain biopsy kn-keyword=brain biopsy en-keyword=cell block pathology kn-keyword=cell block pathology en-keyword=diffuse large b-cell lymphoma kn-keyword=diffuse large b-cell lymphoma en-keyword=natural course kn-keyword=natural course en-keyword=primary central nervous system lymphoma kn-keyword=primary central nervous system lymphoma en-keyword=primary intraocular (vitreoretinal) lymphoma kn-keyword=primary intraocular (vitreoretinal) lymphoma en-keyword=vitrectomy kn-keyword=vitrectomy en-keyword=vitreous opacity kn-keyword=vitreous opacity END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=— •\Ž†E‰p•¶–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰œ•t en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=(1) end-page=(15) dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Organization of the Okayama Domain's Standing Army in Early Meji Japan : Focusing on the gun battalion kn-title=–¾Ž¡‰”N‚É‚¨‚¯‚鉪ŽR”Ë‚Ìí”õŒR•Ò¬ \e‘à‚ð’†S‚É\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MASATSUGUKanako en-aut-sei=MASATSUGU en-aut-mei=Kanako kn-aut-name=­ŽŸ‰Á“ÞŽq kn-aut-sei=­ŽŸ kn-aut-mei=‰Á“ÞŽq aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=143 end-page=163 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An Analysis of the Function of g1GjaŒRh in the Tangut Military System \Positions of g1GjaŒRh and its Relationship with g1T?juEh\ kn-title=¼‰ÄŒR§‚É‚¨‚¯‚éuŒRv‚Ì‹@”\ \uŒRv‚É‘®‚·‚é’nˆÊ–¼Ì‚¨‚æ‚ÑuEv‚Æ‚ÌŠÖŒW\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ONOHiroko en-aut-sei=ONO en-aut-mei=Hiroko kn-aut-name=¬–ì—TŽq kn-aut-sei=¬–ì kn-aut-mei=—TŽq aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=123 end-page=141 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Punishment of Government Officials in the Qin and Han Periods \Focusing on thegFeih andgMianh \ kn-title=`Š¿Žž‘ã‚É‚¨‚¯‚銯—™‚̈”± \uœEv‚Æu–Æv‚ð’†S‚É\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=LIUCong en-aut-sei=LIU en-aut-mei=Cong kn-aut-name=—«‘ kn-aut-sei=—« kn-aut-mei=‘ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=101 end-page=122 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Impact of Free Government Healthcare Insurance on The Utilization of Healthcare Services in Vietnam en-subtitle= kn-subtitle= en-abstract= kn-abstract=@This study investigates the impact of the Free Government Healthcare Insurance (FGHI) scheme on healthcare utilization patterns among enrolled households. Utilizing Tobit regression and Nearest Neighbor Matching (NNM), the analysis revealed a significant positive correlation between scheme enrollment and increased healthcare checkup frequency. However, demographic and geographic variations were evident in the scheme's impact, with ethnic minorities and rural households experiencing a more pronounced rise in healthcare visits compared to the majority group and urban residents. These findings underscore the necessity for tailored policy interventions to address disparities across diverse demographic and geographic strata. Moreover, the FGHI scheme demonstrated effectiveness in encouraging healthcare utilization, particularly among specific demographic groups. This study's insights advocate for more nuanced policy frameworks that consider demographic and geographic nuances, ensuring equitable access to healthcare services for all segments of society. en-copyright= kn-copyright= en-aut-name=Do Thi Hoai Giang en-aut-sei=Do Thi Hoai Giang en-aut-mei= kn-aut-name=ƒh ƒeƒB ƒzƒAƒC ƒWƒƒƒ“ kn-aut-sei=ƒh ƒeƒB ƒzƒAƒC ƒWƒƒƒ“ kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È en-keyword=Free Government Healthcare Insurance kn-keyword=Free Government Healthcare Insurance en-keyword=Nearest Neighbor Matching kn-keyword=Nearest Neighbor Matching en-keyword=Vietnam Healthcare kn-keyword=Vietnam Healthcare END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=83 end-page=100 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Expression 'Fengyue Manting' in the Poetry of Yu Xuanji: On its Formation kn-title=‹›Œº‹@Ž‚ÉŒ©‚ç‚ê‚éu•—ŒŽŸÞ’ëv\‚»‚̬—§‚ɂ‚¢‚Ä\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WangRuochong en-aut-sei=Wang en-aut-mei=Ruochong kn-aut-name=‰¤Žá™t kn-aut-sei=‰¤ kn-aut-mei=Žá™t aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=65 end-page=81 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Regional Response to Securing Transportation through Mutual Assistance \A Case Study of Okayama Prefecture\ kn-title=‹¤•‚É‚æ‚éŒð’ÊŽè’i‚ÌŠm•Û‚ÉŒW‚é’nˆæ“I‘Ήž \‰ªŽRŒ§“à‚ð—á‚É\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KATAOKAKatsumi en-aut-sei=KATAOKA en-aut-mei=Katsumi kn-aut-name=•Ð‰ªŽ–¤ kn-aut-sei=•Ð‰ª kn-aut-mei=Ž–¤ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=45 end-page=64 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Reconsideration of Vocabulary Difficulty Standards in "Easy Japanese": From the subdivision of polysemous words by J-CLID kn-title=u‚₳‚µ‚¢“ú–{Œêv‚É‚¨‚¯‚éŒêœb“ïˆÕ“xŠî€‚ÌÄŒŸ“¢ \J-CLID‚É‚æ‚鑽‹`Œê‚Ìוª—Þ‚©‚ç\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=LUJianhui en-aut-sei=LU en-aut-mei=Jianhui kn-aut-name=˜CŒš‹P kn-aut-sei=˜C kn-aut-mei=Œš‹P aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=25 end-page=44 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on the Relationship between Kazuo Inamori's Philosophy, the Teachings of Nanshu Saigo, and the Iroha Poem by Prince Jisshin kn-title=ˆî·˜a•v‚̃tƒBƒƒ\ƒtƒB[‚Ƽ‹½“ìF‰¥ˆâŒP‹y‚Ñ“úVŒö‚¢‚ë‚͉̘̂AŠÖ‚ɂ‚¢‚Ä‚ÌlŽ@ en-subtitle= kn-subtitle= en-abstract=Kazuo Inamori is a rare business leader who founded DDI, the predecessor of Kyocera and KDDI, in one generation, and grew it into a trillion-yen company. He also rebuilt the bankrupt Japan Airlines (JAL) in three years and led it to relisting. He has not only led tens of thousands of people with his unique management method called amoeba management, but also with management principles. What are the roots of the way of life that a manager of a small and medium-sized business has derived from management? What is the Goju education that is the foundation of Satsuma, where he was born and raised? From the perspective of business management, it is interesting to know what it is like.
How is it related to Saigo Nanshu Ikun, the record of the words and deeds of Saigo Takamori, a local hero whom Kazuo Inamori met after founding Kyocera and used as the basis of his own management philosophy, and Shimazu Nisshin Iroha Uta, left by Shimazu Tadayoshi (Nissin), the father of Shimazu Takahisa, the 15th lord of the Shimazu clan who unified southern Kyushu, including Satsuma and Hyuga, in the 16th century? First of all, I am interested in the relationship between the ideas of the three men born in Satsuma. In this study, we used the grounded theory approach, a qualitative research method, to analyze the correlation between Kazuo Inamori's philosophy, the teachings of Nanshu Saigo, and the Nisshin Iroha Uta. As a result, the analysis revealed that the three concepts are related across 400 years of time. In particular, Kazuo Inamori's philosophy is not only positively influenced by the teachings of Nanshu Saigo, which are the words and deeds of Takamori Saigo, whom Kazuo Inamori admires, but also by the Nisshin Iroha Uta, which dates back 400 years, due to his education in Satsuma. It is believed that the ideals that the people of Satsuma have inherited for 400 years contain concepts that should be the foundation for people's lives, or that should be important core ideas and qualities in life, regardless of the era. kn-abstract=@ˆê‘ã‚Å‹žƒZƒ‰‚âKDDI‚Ì‘Og‚Æ‚È‚é‘æ“ñ“d“diDDIj‚ð‘n‹Æ‚µA‡Œv”’›‰~Šé‹Æ‚Ɉç‚ÄA“|ŽY‚µ‚½“ú–{q‹óiJALj‚ð3”N‚ÅÄŒš‚µAÄãê‚É“±‚¢‚½‹H‘ã‚ÌŒo‰cŽÒˆî·˜a•v‚ÍAƒAƒ[ƒoŒo‰c‚Æ‚¢‚¤“ÆŽ©‚ÌŒo‰cŽè–@‚¾‚¯‚Å‚È‚­A—”OŒo‰c‚É‚æ‚è”–œl‚𓱂¢‚Ä‚«‚½B’†¬Šé‹Æ‚̈êŒo‰cŽÒ‚ªŒo‰c‚Ì’†‚©‚瓱‚«o‚µ‚½l¶¬Œ÷‚̈¢p‚̃‹[ƒc‚͉½ˆ‚É‚ ‚é‚Ì‚©B¶‚Ü‚êˆç‚Á‚½ŽF–€‚ÌŠî‘b‚ƂȂ鋽’†i‚²‚¶‚イj‹³ˆç‚Ƃ͉½‚©A‚Ȃǂɂ‚¢‚ÄŒo‰cŠw‚ÌŠÏ“_‚©‚çŠÖS‚ª—N‚­B
@ˆî·˜a•v‚ª‹žƒZƒ‰‘n‹ÆˆÈ~‚Éo‰ï‚¢AŽ©‚çŒo‰c—”O‚ÌŠî‘b‚Æ‚µ‚½’nŒ³‚̈Ìl‚Å‚ ‚鼋½—²·‚ÌŒ¾s˜^‚Å‚ ‚鼋½“ìF‰¥ˆâŒP‹y‚Ñ16¢‹I‚ÉŽF–€‚â“úŒü‚È‚Ç“ì‹ãB‚ð“ˆê‚µ‚½“‡’ÉƑæ15‘ã—̎哇’ËM‹vŒö‚ÌŽÀ•ƒ“‡’Ã’‰—Çi“úVj‚ªŽc‚µ‚½A“‡’ÓúVŒö‚¢‚ë‚͉̂Ƃǂ̂悤‚ɘAŠÖ‚ª‚ ‚é‚Ì‚©B‚»‚à‚»‚àŽF–€¶‚Ü‚ê‚Ì3–¼‚ÌŽv‘z‚ɂǂ̂悤‚ȘAŠÖ‚ª‚ ‚é‚Ì‚©A‚ɂ‚¢‚Ä‚àŠÖS‚ª—N‚­B‚±‚ÌŒ¤‹†‚Å‚ÍAŽ¿“IŒ¤‹†–@‚Å‚ ‚éƒOƒ‰ƒEƒ“ƒfƒbƒhEƒZƒIƒŠ[EƒAƒvƒ[ƒ`‚ð‰‡—p‚µ‚ÄAˆî·˜a•v‚̃tƒBƒƒ\ƒtƒB[‚Ƽ‹½“ìF‰¥ˆâŒP‹y‚Ñ“úVŒö‚¢‚ë‚͉̘̂AŠÖ‚ɂ‚¢‚Ä•ªÍ‚µ‚½BŒ‹‰Ê“I‚É3‚‚̊T”O‚Í400”N‚ÌŽž‘ã‚ð’´‚¦‚ÄA˜AŠÖ‚µ‚Ä‚¢‚邱‚Æ‚ª•ªÍ‚É‚æ‚è–¾‚ç‚©‚É‚È‚Á‚½B“Á‚Ɉa•v‚̃tƒBƒƒ\ƒtƒB[‚ªˆî·˜a•v‚ªŒhˆ¤‚·‚鼋½—²·‚ÌŒ¾s˜^‚Å‚ ‚鼋½“ìF‰¥ˆâŒP‚ɳ‚̉e‹¿‚ðŽó‚¯‚Ä‚¢‚邾‚¯‚Å‚È‚­AŽF–€‚Å‚Ì‹³ˆç‚ð”wŒi‚ÉA400”N‘O‚É‘k‚é“úVŒö‚¢‚ë‚͉̂©‚ç‚ೂ̉e‹¿‚ðŽó‚¯‚Ä‚¢‚邱‚Æ‚ª–¾‚ç‚©‚É‚È‚Á‚½B400”N‚É“n‚èŽF–€‚ÌlX‚ªŽó‚¯Œp‚¢‚Å‚«‚½—”O‚É‚ÍAŽž‘ã‚ð’´‚¦‚Ä‚àl‚ª¶‚«‚Ä‚¢‚­’†‚ÅŠî‘b‚Æ‚·‚ׂ«A‚à‚µ‚­‚Íl¶‚Åd—v‚ȃRƒA‚ÈŽv‘zEŽ‘Ž¿‚Æ‚·‚ׂ«ŠT”O‚ª‚ ‚é‚Æl‚¦‚ç‚ê‚éB en-copyright= kn-copyright= en-aut-name=MACHIDAHisashi en-aut-sei=MACHIDA en-aut-mei=Hisashi kn-aut-name=’¬“c®Žj kn-aut-sei=’¬“c kn-aut-mei=®Žj aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ en-keyword=ˆî·˜a•v (Kazuo Inamori) kn-keyword=ˆî·˜a•v (Kazuo Inamori) en-keyword=ƒtƒBƒƒ\ƒtƒB[ (philosophy) kn-keyword=ƒtƒBƒƒ\ƒtƒB[ (philosophy) en-keyword=¼‹½—²· (Takamori Saigo) kn-keyword=¼‹½—²· (Takamori Saigo) en-keyword=¼‹½“ìF‰¥ˆâŒP (the teachings of Nanshu Saigo) kn-keyword=¼‹½“ìF‰¥ˆâŒP (the teachings of Nanshu Saigo) en-keyword=“‡’Ã’‰—Çi“úVj (Tadayoshi Shimazu (Nissin)) kn-keyword=“‡’Ã’‰—Çi“úVj (Tadayoshi Shimazu (Nissin)) en-keyword=“úVŒö‚¢‚ë‚Í‰Ì (Nisshin Iroha Uta) kn-keyword=“úVŒö‚¢‚ë‚Í‰Ì (Nisshin Iroha Uta) en-keyword=ƒOƒ‰ƒEƒ“ƒfƒbƒhEƒZƒIƒŠ[EƒAƒvƒ[ƒ` (grounded theory approach) kn-keyword=ƒOƒ‰ƒEƒ“ƒfƒbƒhEƒZƒIƒŠ[EƒAƒvƒ[ƒ` (grounded theory approach) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=15 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=iTranslationjkatrina Jaworski : The Gender of suicide, Part‚Q kn-title=ƒJƒgƒŠ[ƒiEƒWƒƒƒ{ƒ‹ƒXƒLFŽ©ŽE‚ƃWƒFƒ“ƒ_[‚̎ЉïŠw \\•¶Šw•”ƒvƒƒWƒFƒNƒgiƒWƒFƒ“ƒ_[‚Ì‘½‘w«‚ÉŠÖ‚·‚é—̈扡’f“IŒ¤‹†3j‚Ìu‰‰‹L˜^iŒã•Òj\\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SAITOKeisuke en-aut-sei=SAITO en-aut-mei=Keisuke kn-aut-name=âV“¡Œ\‰î kn-aut-sei=âV“¡ kn-aut-mei=Œ\‰î aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=1 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on the Accessibility of Admissions Information: Comparison of universities in Japan, East and South-East Asia and English-speaking countries kn-title=“üŠwî•ñ‚ւ̃AƒNƒZƒX«‚ÉŠÖ‚·‚錤‹† \“ú–{A“ŒE“Œ“ìƒAƒWƒAA‰pŒêŒ—‚Ì‘åŠw‚Æ‚Ì”äŠr‚©‚ç\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=INAMORITakao en-aut-sei=INAMORI en-aut-mei=Takao kn-aut-name=ˆîXŠx‰› kn-aut-sei=ˆîX kn-aut-mei=Šx‰› aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwƒOƒ[ƒoƒ‹lވ笉@ END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž† en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰œ•t en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue= article-no= start-page=(17) end-page=(21) dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=sŽ„‚Ì‘Œê‹³ŽºtV‚µ‚¢u‘ŽÊ‘“¹vŽö‹Æ‚Ì‚ ‚è•û \“‚‘ã‚Ìu–@v‚©‚ç‘v‘ã‚ÌuˆÓv‚ւ̃Vƒtƒg‚ð‘‹}‚É\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‘O“cG—Y kn-aut-sei=‘O“c kn-aut-mei=G—Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue= article-no= start-page=(1) end-page=(16) dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ûüŠKžXˆêu•—‚ÌŒÜü•ˆv‚̉ðŽß \”­‰¹‚©‚玂Ì\‘¢‚ð“ǂ݉ð‚­\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=–”‹g—¢”ü kn-aut-sei=–”‹g kn-aut-mei=—¢”ü aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue= article-no= start-page=15 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=sŽ„‚Ì‘Œê‹³Žºt’nˆæ‚Ì–£—Í‚ªŠw‚ÔˆÓ—~‚ðŠ«‹N‚·‚é en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=’†‰Í•‘ kn-aut-sei=’†‰Í kn-aut-mei=•‘ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Q‰®ìŽs—§‘æŽO’†ŠwZ END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue= article-no= start-page=1 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=–ÚŽw‚·Žq‹Ÿ‘œ‚̉ðŽß‚ð’Ê‚¶‚½‘Œê‰È‚ÌŽö‹Æ‰ü‘P \ƒJƒŠƒLƒ…ƒ‰ƒ€ŠJ”­‚𑣂·‹³Žt‚Ì–ðŠ„‚É’…–Ú‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ˆî–{‘½‰ÁŽu kn-aut-sei=ˆî–{ kn-aut-mei=‘½‰ÁŽu aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw•‘®¬ŠwZ END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž† en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=8366 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250311 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Local-structure insight into the improved superconducting properties of Pb-substituted La(O, F)BiS2: a photoelectron holography study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Pb-substituted La(O, F)BiS2 (Pb-LaOFBiS2) exhibits improved superconducting properties and a resistivity anomaly around 100 K that is attributed to a structural transition. We have performed temperature(T)-dependent photoelectron holography (PEH) to study dopant incorporation sites and the local structure change across the anomaly. The PEH study of Pb-LaOFBiS2 provided evidence for the dominant incorporation sites of Pb and F: Pb atoms are incorporated into the Bi sites and F atoms are incorporated into the O site. No remarkable difference in the local structures around Pb and Bi atoms was observed. Across the temperature of the resistivity anomaly (T*), photoelectron holograms of Bi 4f changed. Comparisons of holograms with those of non-substituted LaOFBiS2 sample, as well as simulated holograms, suggested that (1), above T*, the tetragonal structure of Pb-LaOFBiS2 is different from the tetragonal structure of LaOFBiS2 and (2), below T*, the tetragonal structure still remains in Pb-LaOFBiS2. We discuss a possible origin of the difference in the structure above T* and the implication of the result below T*, which are necessary ingredients to understand the physical properties of Pb-LaOFBiS2. en-copyright= kn-copyright= en-aut-name=LiYajun en-aut-sei=Li en-aut-mei=Yajun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HashimotoYusuke en-aut-sei=Hashimoto en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KataokaNoriyuki en-aut-sei=Kataoka en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SunZexu en-aut-sei=Sun en-aut-mei=Zexu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KawamuraSota en-aut-sei=Kawamura en-aut-mei=Sota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TomitaHiroto en-aut-sei=Tomita en-aut-mei=Hiroto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SetoguchiTaro en-aut-sei=Setoguchi en-aut-mei=Taro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakeuchiSoichiro en-aut-sei=Takeuchi en-aut-mei=Soichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KogaShunjo en-aut-sei=Koga en-aut-mei=Shunjo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamagamiKohei en-aut-sei=Yamagami en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KotaniYoshinori en-aut-sei=Kotani en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=DemuraSatoshi en-aut-sei=Demura en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=NoguchiKanako en-aut-sei=Noguchi en-aut-mei=Kanako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=SakataHideaki en-aut-sei=Sakata en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=MatsushitaTomohiro en-aut-sei=Matsushita en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=WakitaTakanori en-aut-sei=Wakita en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=MuraokaYuji en-aut-sei=Muraoka en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=YokoyaTakayoshi en-aut-sei=Yokoya en-aut-mei=Takayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=5 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=6 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=7 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=8 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=9 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=10 en-affil=Japan Synchrotron Radiation Research Institute (JASRI) kn-affil= affil-num=11 en-affil=Japan Synchrotron Radiation Research Institute (JASRI) kn-affil= affil-num=12 en-affil=Department of Physics, College of Science and Technology(CST), Nihon University kn-affil= affil-num=13 en-affil=Tokyo University of Science kn-affil= affil-num=14 en-affil=Tokyo University of Science kn-affil= affil-num=15 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=16 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=17 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=18 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue= article-no= start-page=1551700 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250305 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Acetoacetate, a ketone body, attenuates neuronal bursts in acutely-induced epileptiform slices of the mouse hippocampus en-subtitle= kn-subtitle= en-abstract= kn-abstract=The ketogenic diet increases ketone bodies (beta-hydroxybutyrate and acetoacetate) in the brain, and ameliorates epileptic seizures in vivo. However, ketone bodies exert weak or no effects on electrical activity in rodent hippocampal slices. Especially, it remains unclear what kinds of conditions are required to strengthen the actions of ketone bodies in hippocampal slices. In the present study, we examined the effects of acetoacetate on hippocampal pyramidal cells in normal slices and epileptiform slices of mice. By using patch-clamp recordings from CA1 pyramidal cells, we first confirmed that acetoacetate did not change the membrane potentials and intrinsic properties of pyramidal cells in normal slices. However, we found that acetoacetate weakened spontaneous epileptiform bursts in pyramidal cells of epileptiform slices, which were acutely induced by applying convulsants to normal slices. Interestingly, acetoacetate did not change the frequency of the epileptiform bursts, but attenuated individual epileptiform bursts. We finally examined the effects of acetoacetate on excitatory synaptic barrages during epileptiform activity, and found that acetoacetate weakened epileptiform bursts by reducing synchronous synaptic inputs. These results show that acetoacetate attenuated neuronal bursts in epileptiform slices, but did not affect neuronal activity in normal slices, which leads to seizure-selective actions of ketone bodies. en-copyright= kn-copyright= en-aut-name=WenHao en-aut-sei=Wen en-aut-mei=Hao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SadaNagisa en-aut-sei=Sada en-aut-mei=Nagisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InoueTsuyoshi en-aut-sei=Inoue en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Biophysical Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Biophysical Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Biophysical Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=epilepsy kn-keyword=epilepsy en-keyword=ketone body kn-keyword=ketone body en-keyword=ketogenic diet kn-keyword=ketogenic diet en-keyword=hippocampus kn-keyword=hippocampus en-keyword=slice physiology kn-keyword=slice physiology en-keyword=patch-clamp recording kn-keyword=patch-clamp recording END start-ver=1.4 cd-journal=joma no-vol=121 cd-vols= no-issue= article-no= start-page=207 end-page=214 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20021115 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Basic Characteristics of Personal Networks of Elderly Women in a Small Japanese City kn-title=ƒƒ‹ƒ{ƒ‹ƒ“‚ÌZ–¯‚Ì•é‚炵 ˆêŽQ—^ŠÏŽ@‚É‚æ‚錤‹†ˆê en-subtitle= kn-subtitle= en-abstract= kn-abstract=@ƒƒ‹ƒ{ƒ‹ƒ“‚ÉZ‚ÞƒI[ƒXƒgƒ‰ƒŠƒAl‚̉ƒë‚Ńz[ƒ€ƒXƒeƒC‚ð‚¨‚±‚È‚¢C‚»‚̉Ƒ°¶Šˆ‚âŒðÛ‚ðŽQ—^ŠÏŽ@‚µ‚½B‚»‚µ‚ÄCŽŸ‚Ì2“_‚𖾂炩‚É‚µ‚½B‡@ƒƒ‹ƒ{ƒ‹ƒ“‚Å‚ÍC‘ål‚Í1‘䂸‚ÂŽÔ‚ðŽ‚‚±‚Æ‚ªˆê”Ê“I‚É‚È‚Á‚Ä‚«‚½BŠOo‚É‚Í‚½‚¢‚Ä‚¢ŽÔ‚ðŽg‚¢C‹ßŠ‚ð•à‚­‚±‚Æ‚ª­‚È‚­‚È‚Á‚½‚©‚çC‹ßŠ‚ÌlX‚Æ’m‚臂¢‚É‚È‚è‚É‚­‚­‚È‚Á‚½B‚»‚±‚ÅC‹ß—׊֌W‚â‹ß—׌ðÛ‚ª–R‚µ‚­‚È‚èC‹ßŠ‚ÌlX‚Æ•‚¯‚ ‚¤‚±‚Æ‚à‚ ‚Ü‚è‚È‚­‚È‚Á‚½B‡AŽÔ‚ðŽg‚Á‚ÄŠOo‚ð‚·‚é‚Ì‚ÅCŽ©—R‚És‚«—ˆ‚Å‚«‚é’n—“I”͈͂ªL‚­‚È‚Á‚½B‚»‚Ì‚½‚ßCZ–¯‚ÍL”͈͂ÉZ‚Þ‘½‚­‚ÌlX‚Ì’†‚©‚çC‹CS‚ª‚ ‚Á‚½‚èC—˜ŠQ‚âŠÖS‚ð‹¤—L‚·‚é‘ŠŽè‚ðŽ©—R‚É‘I‚ñ‚Å—FlŠÖŒW‚ðŽæ‚茋‚ÑC‚»‚¤‚µ‚½—Fl‚ÆŒð—V‚ð‚µ‚½‚èC¶Šˆ‚Ì•‚¯‡‚¢‚ð‚¨‚±‚È‚Á‚Ä‚¢‚éB en-copyright= kn-copyright= en-aut-name=NOBEMasao en-aut-sei=NOBE en-aut-mei=Masao kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Social Studies Education, Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆçŠw•”ŽÐ‰ï‰È‹³ˆçuÀ en-keyword=ƒƒ‹ƒ{ƒ‹ƒ“ kn-keyword=ƒƒ‹ƒ{ƒ‹ƒ“ en-keyword=ŽQ—^ŠÏŽ@ kn-keyword=ŽQ—^ŠÏŽ@ en-keyword=ƒp[ƒ\ƒiƒ‹Eƒlƒbƒgƒ[ƒN kn-keyword=ƒp[ƒ\ƒiƒ‹Eƒlƒbƒgƒ[ƒN en-keyword=ƒ\[ƒVƒƒƒ‹EƒTƒ|[ƒg kn-keyword=ƒ\[ƒVƒƒƒ‹EƒTƒ|[ƒg END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue= article-no= start-page=219 end-page=227 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030710 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Trend Analysis of Migration in a Small Local Japanese City kn-title=’n•û¬“sŽs‚É‚¨‚¯‚élŒû‚Ì’n—“IˆÚ“®‚Ì–¨•ªÍ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@‚—ÀŽs‚ÍC‰ªŽRŒ§‚Ì’†¼•”‚Ɉʒu‚·‚é’n•û¬“sŽs‚Å‚ ‚éB–{e‚Å‚ÍC1965”NC1975”NC1985”NC1995”NC2000”N‚É‚¨‚¯‚éC‚—ÀŽs‚ÌlŒû‚Ì’n—“IˆÚ“®‚ÉŠÖ‚·‚éƒf[ƒ^‚ðŒŸ“¢‚µ‚»‚Ì–¨‚𖾂炩‚É‚µ‚½B en-copyright= kn-copyright= en-aut-name=NOBEMasao en-aut-sei=NOBE en-aut-mei=Masao kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Social Studies Education, Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆçŠw•”ŽÐ‰ï‰È‹³ˆçuÀ en-keyword=’n—“IˆÚ“® kn-keyword=’n—“IˆÚ“® en-keyword=“]“üE“]o kn-keyword=“]“üE“]o en-keyword=ƒˆÚ“®” kn-keyword=ƒˆÚ“®” en-keyword=’n•û¬“sŽs kn-keyword=’n•û¬“sŽs END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue= article-no= start-page=113 end-page=121 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20031115 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Trend Analysis of Migration in Okayama City, Japan kn-title=‰ªŽRŽs‚É‚¨‚¯‚élŒû‚Ì’n—“IˆÚ“®‚Ì–¨•ªÍ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@‰ªŽRŽs‚ÍClŒû–ñ63–œl‚Ì’n•û’†Šj“sŽs‚Å‚ ‚éB–{e‚Å‚ÍC1965”NC1975”NC1985”NC1995”NC2000”N‚É‚¨‚¯‚éC‰ªŽRŽs‚̃f[ƒ^‚ðŒŸ“¢‚µClŒû‚Ì’n—“IˆÚ“®‚Ì–¨‚𖾂炩‚É‚µ‚½B‚³‚ç‚ÉC‰ªŽRŒ§‚Ì’n•û¬“sŽs‚Å‚ ‚é‚—ÀŽs‚Ì’n—“IˆÚ“®‚Æ”äŠr‚ð‚¨‚±‚È‚Á‚½B en-copyright= kn-copyright= en-aut-name=NOBEMasao en-aut-sei=NOBE en-aut-mei=Masao kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Social Studies Education, Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆçŠw•”ŽÐ‰ï‰È‹³ˆçuÀ en-keyword=’n—“IˆÚ“® kn-keyword=’n—“IˆÚ“® en-keyword=“]“üE“]o kn-keyword=“]“üE“]o en-keyword=ƒˆÚ“®” kn-keyword=ƒˆÚ“®” en-keyword=‰ªŽRŽs kn-keyword=‰ªŽRŽs END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue= article-no= start-page=107 end-page=110 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Research Note on Aged Care Services in Melbourne kn-title=ƒƒ‹ƒ{ƒ‹ƒ“‚É‚¨‚¯‚é‚—îŽÒ‚ւ̃PƒAEƒT[ƒrƒX‚ƉîŒìƒT[ƒrƒX en-subtitle= kn-subtitle= en-abstract= kn-abstract=@•MŽÒ‚̓ƒ‹ƒ{ƒ‹ƒ“‘å“sŽsŒ—‚É‚ ‚éƒzƒƒCƒgƒz[ƒXŽs‚ÅŽs–ðŠ‚Ì•ŸŽƒ’S“–ŽÒ‚⋳‰ï‚ª‰^‰c‚·‚éƒi[ƒVƒ“ƒOEƒz[ƒ€‚ð–K–₵C‚—îŽÒ‚ւ̃PƒAEƒT[ƒrƒX‚â‰îŒìƒT[ƒrƒX‚ÉŠÖ‚µ‚Ä‚Ì•·‚«Žæ‚è’²¸‚⎑—¿ŽûW‚ð‚¨‚±‚È‚Á‚½B–{e‚Å‚ÍC‚»‚Ì•·‚«Žæ‚è’²¸‚âŽûW‚µ‚½Ž‘—¿‚É‚à‚Ƃ¢‚ÄC“¯Žs‚É‚¨‚¯‚éƒPƒAEƒT[ƒrƒX‚ƉîŒìƒT[ƒrƒX‚ÌŒ»ó‚ðЉ‚½B en-copyright= kn-copyright= en-aut-name=NOBEMasao en-aut-sei=NOBE en-aut-mei=Masao kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Social Studies Education, Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆçŠw•”ŽÐ‰ï‰È‹³ˆçuÀ en-keyword=ƒLƒƒ‹ƒ{ƒ‹ƒ“ kn-keyword=ƒLƒƒ‹ƒ{ƒ‹ƒ“ en-keyword=‚—îŽÒ kn-keyword=‚—îŽÒ en-keyword=ƒPƒAEƒT[ƒrƒX kn-keyword=ƒPƒAEƒT[ƒrƒX en-keyword=‰îŒìƒT[ƒrƒX kn-keyword=‰îŒìƒT[ƒrƒX END start-ver=1.4 cd-journal=joma no-vol=85 cd-vols= no-issue=6 article-no= start-page=1082 end-page=1096 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Myeloid Cells Induce Infiltration and Activation of B Cells and CD4+ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy en-subtitle= kn-subtitle= en-abstract= kn-abstract=Brain metastasis is a poor prognostic factor in patients with cancer. Despite showing efficacy in many extracranial tumors, immunotherapy with anti?PD-1 mAb or anti?CTLA4 mAb seems to be less effective against intracranial tumors. Promisingly, recent clinical studies have reported that combination therapy with anti?PD-1 and anti?CTLA4 mAbs has a potent antitumor effect on brain metastasis, highlighting the need to elucidate the detailed mechanisms controlling the intracranial tumor microenvironment (TME) to develop effective immunotherapeutic strategies. In this study, we analyzed the tumor-infiltrating lymphocytes in murine models of brain metastasis that responded to anti?CTLA4 and anti?PD-1 mAbs. Activated CD4+ T follicular helper (TFH) cells with high CTLA4 expression characteristically infiltrated the intracranial TME, which were activated by combination anti?CTLA4 and anti?PD-1 treatment. The loss of TFH cells suppressed the additive effect of CTLA4 blockade on anti?PD-1 mAb. B-cell?activating factor belonging to the TNF family (BAFF) and a proliferation-inducing ligand (APRIL) produced by abundant myeloid cells, particularly CD80hiCD206lo proinflammatory M1-like macrophages, in the intracranial TME induced B-cell and TFH-cell infiltration and activation. Furthermore, the intracranial TME of patients with non?small cell lung cancer featured TFH- and B-cell infiltration as tertiary lymphoid structures. Together, these findings provide insights into the immune cell cross-talk in the intracranial TME that facilitates an additive antitumor effect of CTLA4 blockade with anti?PD-1 treatment, supporting the potential of a combination immunotherapeutic strategy for brain metastases.
Significance: B-cell and CD4+ T follicular helper cell activation via BAFF/APRIL from abundant myeloid cells in the intracranial tumor microenvironment enables a combinatorial effect of CTLA4 and PD-1 blockade in brain metastases. en-copyright= kn-copyright= en-aut-name=NinomiyaToshifumi en-aut-sei=Ninomiya en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KemmotsuNaoya en-aut-sei=Kemmotsu en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MukoharaFumiaki en-aut-sei=Mukohara en-aut-mei=Fumiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MagariMasaki en-aut-sei=Magari en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyamotoAi en-aut-sei=Miyamoto en-aut-mei=Ai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UedaYouki en-aut-sei=Ueda en-aut-mei=Youki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IshinoTakamasa en-aut-sei=Ishino en-aut-mei=Takamasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NagasakiJoji en-aut-sei=Nagasaki en-aut-mei=Joji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FujiwaraTomohiro en-aut-sei=Fujiwara en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamamotoHidetaka en-aut-sei=Yamamoto en-aut-mei=Hidetaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=HayashiHidetoshi en-aut-sei=Hayashi en-aut-mei=Hidetoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=TachibanaKota en-aut-sei=Tachibana en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=IshidaJoji en-aut-sei=Ishida en-aut-mei=Joji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=OtaniYoshihiro en-aut-sei=Otani en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=TanakaShota en-aut-sei=Tanaka en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=OkamotoIsamu en-aut-sei=Okamoto en-aut-mei=Isamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=TogashiYosuke en-aut-sei=Togashi en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= affil-num=1 en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=5 en-affil=Medical Protein Engineering, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=6 en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Orthopaedic Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Pathology and Oncology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Medical Oncology, Kindai University Faculty of Medicine kn-affil= affil-num=12 en-affil=Department of Dermatology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=13 en-affil=Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=14 en-affil=Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=15 en-affil=Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=16 en-affil=Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Science, Okayama University kn-affil= affil-num=17 en-affil=Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University kn-affil= affil-num=18 en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=— •\Ž†E‰p•¶–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰œ•t en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰ªŽR‘åŠw‹³Žt‹³ˆçŠJ”­ƒZƒ“ƒ^[‹I—vŒ´eŽ·•M—v—Ì en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰ªŽR‘åŠw‹³Žt‹³ˆçŠJ”­ƒZƒ“ƒ^[‚ÌŠˆ“®ó‹µ‚ÌŠT—v en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=357 end-page=371 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Proposals for Supporting Childrenfs Adaptation in School Mergers and Closures kn-title=ŠwZ“”p‡‚É‚¨‚¯‚鎙“¶‚Ì“K‰žŽx‰‡ô‚Ì’ñŒ¾ en-subtitle= kn-subtitle= en-abstract=The purpose of this study is to examine the impact of school mergers and closures on children through a literature review and field survey and to propose strategies for supporting children's adaptation to the resulting environmental transitions. First, a literature review on school mergers and closures indicated that such experiences could influence children's later interpersonal relationships and increase stress responses. However, research on the impact of school mergers and closures on children remains limited, with insufficient understanding of their psychological effects on children. Next, interviews conducted as part of a field survey revealed that school mergers and closures could be significant sources of stress for children. Based on these findings, we recommends multi-level support measures targeting individuals, classes, grades, and entire schools, primarily through special activities, to help mitigate the impact of these transitions on children. kn-abstract=–{Œ¤‹†‚Ì–Ú“I‚ÍCŠwZ“”p‡‚ÉŒW‚镶Œ£ŒŸõ‚¨‚æ‚ÑŽÀ‘Ô’²¸‚ð’Ê‚µ‚ÄCŠwZ“”p‡‚Æ‚¢‚¤ŠÂ‹«ˆÚs‚ªŽ™“¶‚É—^‚¦‚é‰e‹¿‚ɂ‚¢‚ÄŒŸ“¢‚µCŠwZ“”p‡‚ª‚à‚½‚ç‚·ŠÂ‹«ˆÚs‚ɑ΂·‚鎙“¶‚Ì“K‰žŽx‰‡ô‚ɂ‚¢‚Ä’ñŒ¾‚·‚邱‚Æ‚Å‚ ‚éB‚Ü‚¸CŠwZ“”p‡‚ÉŒW‚镶Œ£ŒŸõ‚ðs‚Á‚½Œ‹‰ÊCŠwZ“”p‡‚ÌŒoŒ±‚ªŽ™“¶¶“k‚Ì‚»‚ÌŒã‚ÌlŠÔŠÖŒWŒ`¬‚âƒXƒgƒŒƒX”½‰ž‚Ì‘‰Á‚ɉe‹¿‚ð—^‚¦‚Ä‚¢‚é‰Â”\«‚ªŽ¦‚³‚ꂽB‚µ‚©‚µCŠwZ“”p‡‚ªŽ™“¶‚É—^‚¦‚é‰e‹¿‚ÉŠÖ‚·‚錤‹†‚Í”ñí‚É­‚È‚­C“”p‡‚ÌŒoŒ±‚ªŽ™“¶‚É—^‚¦‚éS—“I‰e‹¿‚ɂ‚¢‚Ä‚Í\•ª‚ɉ𖾂³‚ê‚Ä‚¢‚È‚¢‚±‚Æ‚ª‚í‚©‚Á‚½BŽŸ‚ÉCŽÀ‘Ô’²¸‚Æ‚µ‚Äs‚Á‚½ƒCƒ“ƒ^ƒrƒ…[‚É‚¨‚¢‚ÄCŠwZ“”p‡‚ªŽ™“¶‚É‚Æ‚Á‚Ä‘å‚«‚ȃXƒgƒŒƒX—vˆö‚Æ‚È‚é‰Â”\«‚ª‚ ‚邱‚Æ‚ª‚í‚©‚Á‚½B‚±‚ê‚ç‚ÌŒ»ó‚𓥂܂¦‚ÄCŠwZ“”p‡‚ªŽ™“¶‚É—^‚¦‚é‰e‹¿‚ð˜a‚ç‚°‚邽‚ßC“Á•ÊŠˆ“®‚ð’†S‚Æ‚µ‚ÄCŒÂlEŠw‹‰EŠw”NEŠwZƒŒƒxƒ‹‚Å‚Ì‹ï‘Ì“I‚ÈŽæ‘g‚ð’ñˆÄ‚µ‚½B en-copyright= kn-copyright= en-aut-name=IKEDAYuka en-aut-sei=IKEDA en-aut-mei=Yuka kn-aut-name=’r“c?‰Á kn-aut-sei=’r“c kn-aut-mei=?‰Á aut-affil-num=1 ORCID= en-aut-name=IZUMITsuguyuki en-aut-sei=IZUMI en-aut-mei=Tsuguyuki kn-aut-name=ˆÉZŒps kn-aut-sei=ˆÉZ kn-aut-mei=Œps aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Education (Professional Degree Corse), Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@¶ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=ŠwZ“”p‡ (School Consolidation) kn-keyword=ŠwZ“”p‡ (School Consolidation) en-keyword=Ž™“¶ (Children) kn-keyword=Ž™“¶ (Children) en-keyword=lŠÔŠÖŒWŒ`¬ (Relationship Building) kn-keyword=lŠÔŠÖŒWŒ`¬ (Relationship Building) en-keyword=ƒXƒgƒŒƒX (Stress) kn-keyword=ƒXƒgƒŒƒX (Stress) en-keyword=“Á•ÊŠˆ“® (Special Activities) kn-keyword=“Á•ÊŠˆ“® (Special Activities) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=341 end-page=355 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Research Trends on Educational Needs and Support of Children with Cancer kn-title=¬Ž™‚ª‚ñŠ³Ž™‚ɑ΂·‚鋳ˆç“IŽx‰‡‚Æ‚»‚ÌŒ¤‹†“®Œü en-subtitle= kn-subtitle= en-abstract=@In this study, we summarized research trends related to the educational needs and support of children with cancer from the perspectives of glearning,h gself-management,h ginterpersonal,h gpsychological,h and gcollaboration,h. In terms of learning, the study showed that experiential learning and distance education are solutions to the problem of delayed learning due to prolonged absence from school and poor concentration during treatment. Next, in self-management, it is important to educate affected children so that they can fully understand the disease and treatment. In addition, in terms of interpersonal support, it is difficult for the affected patients to build relationships with friends, but providing opportunities for interaction is expected to contribute to the improvement of interpersonal relationships. In terms of psychological support, the anxiety associated with treatment is a major psychological burden for the affected children, and the understanding of their friends and the intervention of university student volunteers are effective in helping them achieve psychological stability. Finally, the lack of cooperation between medical institutions and schools was highlighted as a deficiency in the support system, which needs to be strengthened. In the future, these support measures should be empirically verified to establish a sustainable support system. kn-abstract=@–{Œ¤‹†‚ÍA¬Ž™‚ª‚ñŠ³Ž™‚Ì‹³ˆç“IŽx‰‡‚ÉŠÖ‚·‚錤‹†‚Ì“®Œü‚𖾂炩‚É‚µA¡Œã‚̉ۑè‚Æ‚»‚̉ðŒˆô‚ð’ñ‹N‚·‚邱‚Æ‚ð–Ú“I‚Æ‚µ‚½BuŠwKvAuŽ©ŒÈŠÇ—vAu‘ÎlvAuS—vAu˜AŒgv‚Ì5‚‚̎‹“_‚©‚番͂ðs‚Á‚½BŠwKŽx‰‡‚ɂ‚¢‚ÄAŽ¡—Âɔº‚¤ŠwK‚Ì’x‚ê‚âW’†—͂̒ቺ‚ɑ΂µAŒÂ•Ê‚Ì‹³ˆçŽx‰‡Œv‰æ‚â‘ÌŒ±“I‚ÈŠwKA‚¨‚æ‚щ“Šu‹³ˆç‚ÌŽÀŽ{‚ÉŠú‘Ò‚³‚ê‚Ä‚¢‚½BŽ©ŒÈŠÇ—Žx‰‡‚Å‚ÍAŠ³Ž™‚ªŽ©g‚Ì•aó‚⎡—Âɂæ‚é•›ì—p‚ð—‰ð‚µAŽ©—§“I‚ÉŠÇ—‚Å‚«‚é”\—Í‚ðˆç¬‚·‚邱‚Æ‚ª‹‚ß‚ç‚ê‚Ä‚¢‚½B‘ÎlŽx‰‡‚ɂ‚¢‚ÄAŠ³Ž™‚Ì’·Šú“ü‰@‚É‚æ‚èA—FlŠÖŒW‚Ì\’z‚ª¢“ï‚É‚È‚èA“ü‰@’†‚â•œŠwŒã‚̃Rƒ~ƒ…ƒjƒP[ƒVƒ‡ƒ“‚ÌŽx‰‡‚ªd—v‚Å‚ ‚邱‚Æ‚ªŠm”F‚³‚ꂽBS—Žx‰‡‚É‚¨‚¢‚Ä‚ÍAŽüˆÍ‚Ö‚ÌŒø‰Ê“I‚È‚ª‚ñ‹³ˆç‚â‘åŠw¶ƒ{ƒ‰ƒ“ƒeƒBƒA‚É‚æ‚éŽx‰‡‚ªAŠ³Ž™‚ÌS—“IˆÀ’è‚𑣂·‚±‚Æ‚ªŽ¦‚³‚ꂽBÅŒã‚ÉAŠwZ‚ƈã—Ë@ŠÖA•ÛŒìŽÒ‚̘AŒg•s‘«‚ªŽw“E‚³‚ê‚Ä‚¨‚èA˜AŒgƒc[ƒ‹‚ÌŠJ”­‚ª‹‚ß‚ç‚ê‚Ä‚¢‚éB en-copyright= kn-copyright= en-aut-name=CHENYiwen en-aut-sei=CHEN en-aut-mei=Yiwen kn-aut-name=’ˆ˕¶ kn-aut-sei=’ kn-aut-mei=ˆË•¶ aut-affil-num=1 ORCID= en-aut-name=YOSHITOSHIMunehisa en-aut-sei=YOSHITOSHI en-aut-mei=Munehisa kn-aut-name=‹g—˜@‹v kn-aut-sei=‹g—˜ kn-aut-mei=@‹v aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Education Doctoral Programs, Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@˜A‡ŠwZ‹³ˆçŠwŒ¤‹†‰È”ŽŽm‰Û’ö affil-num=2 en-affil=Graduate School of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=¬Ž™‚ª‚ñ (child hood cancer) kn-keyword=¬Ž™‚ª‚ñ (child hood cancer) en-keyword=–«Ž¾Š³ (chronic illness) kn-keyword=–«Ž¾Š³ (chronic illness) en-keyword=‹³ˆç“Iƒj[ƒY (educational needs) kn-keyword=‹³ˆç“Iƒj[ƒY (educational needs) en-keyword=Œ¤‹†“®Œü (research trends) kn-keyword=Œ¤‹†“®Œü (research trends) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=325 end-page=339 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Recommendations on how to View STEAM Education in General Education and Development of Classes and Teacher Training ?Through the Enrichment of Integrated Inquiry Time? kn-title=•’ʉȂɂ¨‚¯‚é STEAM ‹³ˆç‚Ì‘¨‚¦•û‚Ì’ñŒ¾‚ÆŽö‹Æ‚¨‚æ‚Ñ‹³ˆõŒ¤C‚ÌŠJ”­@\‘‡“I‚È’T‹†‚ÌŽžŠÔ‚Ì[ŽÀ‚ð’Ê‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–{ŽÀ‘H•ñ‚Å‚ÍC•’ʉȂɂ¨‚¯‚é STEAM ‹³ˆç‚Ì‘¨‚¦•û‚ð’ñŒ¾‚µC‹ï‘Ì“I‚ÈŽö‹ÆŽÀ‘H‚⋳ˆõŒ¤C‚ð’ñˆÄ‚·‚éBæsŒ¤‹†“™‚Å‹c˜_‚³‚ê‚Ä‚¢‚é STEAM ‹³ˆç‚ÌŠT”O“™‚©‚çCSTEAM ‹³ˆç‚̪Š²‚Í‘n‘¢«‚🼗{EŽhŒƒE”­Šö‚·‚鋳ˆç‚Å‚ ‚é‚Æ‘¨‚¦CSTEAM ‹³ˆç‚ÆÅ‚àe˜a«‚ª‚‚¢‘‡“I‚È’T‹†‚ÌŽžŠÔ‚ÅŽö‹ÆŽÀ‘H‚ðs‚Á‚½BŽæ‚è‘g‚Ý‚ÌŒø‰Ê‚ɂ‚¢‚Ä‚ÍC¬‰Ê•¨‚Ì•ªÍ‚âƒqƒAƒŠƒ“ƒO’²¸“™‚ð’Ê‚µ‚ÄŒŸØ‚µC’T‹†‚ðŽ©•ªŽ–‚É‚Å‚«‚Ä‚¢‚邱‚Æ‚ªŽ¦´‚³‚ꂽB‚Ü‚½C¶“k‚ª‘n‘¢«‚🼗{EŽhŒƒE”­Šö‚·‚éê–Ê‚ÍCŠe‹³‰È“™‚ÌŽö‹Æ“à‚Å‚àŽÀŒ»‚Å‚«‚é‚Æl‚¦CuŠy‚µ‚­[‚Ü‚éŽö‹Æv‚ðƒe[ƒ}‚É‚µ‚½‹³ˆõŒ¤C‚ÌŠJ”­‚ðs‚Á‚½B‚±‚ÌŒ¤C‚Å‚ÍŽö‹ÆŠJ”­‚ð‹³ˆõ‚̃`[ƒ€’T‹†‚Æ‘¨‚¦C‘‡“I‚È’T‹†‚ÌŽžŠÔ‚Ŷ“k‚ªŽæ‚è‘g‚Þƒ[ƒN“™‚àŠˆ—p‚µ‚½B‘‡“I‚È’T‹†‚ÌŽžŠÔ‚ðŽó‚¯‚½ŒoŒ±‚Ì‚È‚¢‹³ˆõ‚ª’T‹†Šˆ“®‚̃vƒƒZƒX‚ðŒoŒ±‚µC’T‹†‚ÌŠy‚µ‚³‚⃃NƒƒNŠ´‚ðŽÀŠ´‚Å‚«‚邱‚Æ‚à‘_‚Á‚Ä‚¢‚éBŽå‘Ì“I‚ÅŠˆ”­‚È‘SZŒ¤C‚ªŽÀŒ»‚µC‹³ˆõ‚ª’T‹†“I‚ÉŽö‹Æ‘n‚è‚ði‚߂邱‚Æ‚Ì‚Å‚«‚錤C‚ÌŽdŠ|‚¯‚ðŒ©o‚·‚±‚Æ‚ª‚Å‚«‚½B en-copyright= kn-copyright= en-aut-name=EBARAMitsuo en-aut-sei=EBARA en-aut-mei=Mitsuo kn-aut-name=]Œ´Œõ•v kn-aut-sei=]Œ´ kn-aut-mei=Œõ•v aut-affil-num=1 ORCID= en-aut-name=INADAYoshihiko en-aut-sei=INADA en-aut-mei=Yoshihiko kn-aut-name=ˆî“c‰À•F kn-aut-sei=ˆî“c kn-aut-mei=‰À•F aut-affil-num=2 ORCID= affil-num=1 en-affil=Okayama Prefectural Kurashiki Amaki High School (Graduate School of Education (Professional Degree Corse), Okayama University) kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@¶ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=STEAM ‹³ˆç (STEAM education) kn-keyword=STEAM ‹³ˆç (STEAM education) en-keyword=‘n‘¢« (creativity) kn-keyword=‘n‘¢« (creativity) en-keyword=‘‡“I‚È’T‹†‚ÌŽžŠÔ (integrated inquiry time) kn-keyword=‘‡“I‚È’T‹†‚ÌŽžŠÔ (integrated inquiry time) en-keyword=•’Ê‰È (general education) kn-keyword=•’Ê‰È (general education) en-keyword=‹³ˆõŒ¤C (teacher training) kn-keyword=‹³ˆõŒ¤C (teacher training) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=313 end-page=324 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An Attempt at International Understanding Education Incorporating Letter Exchange Activities between Japanese and Chinese High School Students: Through Development of a Civics Unit Plan on International Issues kn-title=“ú’†‚Ì‚Z¶‚̎莆‚ðŽg‚Á‚½Œð—¬Šˆ“®‚ðŽæ‚è“ü‚ꂽ‘Û—‰ð‹³ˆç‚ÌŽŽ‚Ý@\‘Û“I‰Û‘è‚ðŽæ‚èã‚°‚½Œö–¯‰È‚Ì’PŒ³ŠJ”­\ en-subtitle= kn-subtitle= en-abstract=This study reports the results of the development and practice of a class in which Japanese and Chinese high school students deepened mutual understanding and became aware of themselves as members of the international community through l earning activities in which they exchanged letters in order to share their thoughts on a global international issue. Through the practice, it became clear that exchange activities have the following significance for students. Firstly, it was the first one-on-one exchange with a foreigner. Even if they did not meet directly, for many of the students in this class, it was their first experience to interact with people from other countries. Secondly, it was an opportunity for them to develop an interest in other cultures and schools. Thirdly, the students were able to consider the issue of climate change from a global perspective. kn-abstract=@–{Œ¤‹†‚ÍC“ú–{‚Æ’†‘‚Ì‚Z¶‚ª’n‹…‹K–Í‚Ì‘Û“I‰Û‘è‚ɂ‚¢‚Äl‚¦‚ð‹¤—L‚·‚邽‚ß‚ÉCŽèŽ†‚ðŒðŠ·‚·‚éŠwKŠˆ“®‚ð’Ê‚µ‚Ä‘ŠŒÝ—‰ð‚ð[‚ßC‘ێЉï‚̈êˆõ‚Æ‚µ‚Ä‚ÌŽ©Šo‚ðŽ‚‚悤‚ɂȂ邱‚Æ‚ð–ÚŽw‚µ‚½Žö‹Æ‚ÌŠJ”­EŽÀ‘H‚̬‰Ê‚ð•ñ‚·‚é‚à‚Ì‚Å‚ ‚éBŽÀ‘H‚ð’Ê‚µ‚ÄCŒð—¬Šˆ“®‚Ͷ“k‚É‚Æ‚Á‚ÄŽŸ‚̂悤‚ȈӋ`‚ª‚ ‚邱‚Æ‚ª–¾‚ç‚©‚É‚È‚Á‚½B‘æ[‚ÍCŠO‘l‚Ƃ̉‚߂Ă̈ê‘Έê‚̌𗬂ł ‚Á‚½‚Æ‚¢‚¤‚±‚Æ‚Å‚ ‚éB’¼Ú‰ï‚í‚È‚¢Œ`‚Å‚ ‚Á‚½‚Æ‚µ‚Ä‚àC¡‰ñ‚ÌŽö‹Æ‚ðŽó‚¯‚½‘½‚­‚̶“k‚É‚Æ‚Á‚Ä‚Í‘¼‚Ì‘‚Ìl‚ÆŠÖ‚í‚鉂߂Ă̌oŒ±‚Å‚ ‚Á‚½B‘æ“ñ‚ÍC‘¼‘‚Ì•¶‰»‚âŠwZ‚Ö‚ÌŠÖS‚ðŽ‚‚«‚Á‚©‚¯‚Æ‚È‚Á‚½‚±‚Æ‚Å‚ ‚éB‘æŽO‚ÍC‹CŒó•Ï“®–â‘è‚ɑ΂µ‚ăOƒ[ƒoƒ‹‚ÈŽ‹“_‚Ål‚¦‚é‚«‚Á‚©‚¯‚ð—^‚¦‚ç‚ꂽ‚Æ‚¢‚¤‚±‚Æ‚Å‚ ‚éB en-copyright= kn-copyright= en-aut-name=BEKKIMoeka en-aut-sei=BEKKI en-aut-mei=Moeka kn-aut-name=•Ê–Ø–G‰Ê kn-aut-sei=•Ê–Ø kn-aut-mei=–G‰Ê aut-affil-num=1 ORCID= en-aut-name=ZHOUXingxing en-aut-sei=ZHOU en-aut-mei=Xingxing kn-aut-name=Žü¯¯ kn-aut-sei=Žü kn-aut-mei=¯¯ aut-affil-num=2 ORCID= en-aut-name=KUWABARAToshinori en-aut-sei=KUWABARA en-aut-mei=Toshinori kn-aut-name=ŒKŒ´•q“T kn-aut-sei=ŒKŒ´ kn-aut-mei=•q“T aut-affil-num=3 ORCID= affil-num=1 en-affil=Tokyo Metropolitan Ogawa High School kn-affil=“Œ‹ž“s—§¬ì‚“™ŠwZ affil-num=2 en-affil=School of Foreign Languages, Shijiazhuang University kn-affil=ΉƑ‘Šw‰@ŠO‘ŒêŠw‰@i’†‘j affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=‘Û—‰ð‹³ˆç (international understanding education) kn-keyword=‘Û—‰ð‹³ˆç (international understanding education) en-keyword=Œö–¯‰È (civics) kn-keyword=Œö–¯‰È (civics) en-keyword=’PŒ³ŠJ”­ (unit development) kn-keyword=’PŒ³ŠJ”­ (unit development) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=297 end-page=311 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Exploring Home Learning That Bridges Lessons to Foster Autonomous and Self-Directed Learning kn-title=Žå‘Ì“IEŽ©—¥“I‚ÈŠw‚Ñ‚ð–G‰è‚³‚¹‚éuŽö‹Æ‚ÆŽö‹Æ‚ð‚‚Ȃ®‰Æ’ëŠwKv‚Ì’T‹† en-subtitle= kn-subtitle= en-abstract=@For students to develop the ability to learn independently, they need learning experiences that extend beyond the classroom, including at home. In other words, learning is not confined to the classroom but is reinforced through a wide range of activities. This study aimed to nurture gautonomous and self-directed learningh among students in the second grade at a public junior high school by integrating classroom and home learning. Teachers emphasized the importance of learning strategies and goal setting, and encouraged metacognition. As a result, students became more aware of the self-regulated learning cycle and began exploring learning strategies tailored to their needs. In addition, working at home on assignments connected to the class not only increased studentsf active participation in class but also improved their motivation to learn independ ently outside of class. kn-abstract=@¶“k‚ªŽ©‚çŠwK‚ði‚ß‚Ä‚¢‚­—Í‚ðg‚É•t‚¯‚é‚É‚ÍCŽö‹Æ“à‚¾‚¯‚Å‚È‚­C‰Æ’ë‚È‚ÇŽö‹ÆŠO‚Ìê‚Å‚ÌŠwKŒoŒ±‚ðÏ‚Þ•K—v‚ª‚ ‚éB‚‚܂èCŠwK‚ÍŽö‹Æ“à‚¾‚¯‚ÅŠ®Œ‹‚·‚é‚Ì‚Å‚Í‚È‚­CL”Í‚ÈŠˆ“®‚ð’Ê‚µ‚Ĭ—§‚·‚éB–{Œ¤‹†‚Å‚ÍCŒö—§’†ŠwZ‚Ì‘æ2Šw”N‚ð‘ÎÛ‚ÉŽö‹Æ‚ƉƒëŠwK‚ð˜AŒg‚³‚¹‚éŽÀ‘H‚ðs‚¢C¶“k‚ÌuŽå‘Ì“IEŽ©—¥“I‚ÈŠw‚Ñv‚ð–G‰è‚³‚¹‚邱‚Æ‚ð–ÚŽw‚µ‚½B‹³Žt‚ªŠwK•û—ª‚â–Ú•WÝ’è‚Ìd—v«‚ð“`‚¦Cƒƒ^”F’m‚𑣂·‚±‚Æ‚ÅC¶“k‚ÍŽ©ŒÈ’²®ŠwK‚̃TƒCƒNƒ‹‚ðˆÓŽ¯‚µCŽ©•ª‚È‚è‚ÌŠwK•û—ª‚ð’T‹‚·‚é‚悤‚É‚È‚Á‚½B‚Ü‚½C‰Æ’ëŠwK‚ÅŽö‹Æ‚ɂ‚Ȃª‚é‰Û‘è‚ÉŽæ‚è‘g‚Þ‚±‚Æ‚ÅCŽö‹Æ‚Ö‚ÌŽå‘Ì“I‚ÈŽQ‰Á‚ÆCŽö‹ÆŠO‚ÅŽ©—¥“I‚ÉŠw‚ÔˆÓ—~‚ª‘£‚³‚ê‚邱‚Æ‚àŽ¦´‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=TANAKAJunko en-aut-sei=TANAKA en-aut-mei=Junko kn-aut-name=“c’†ƒŽq kn-aut-sei=“c’† kn-aut-mei=ƒŽq aut-affil-num=1 ORCID= en-aut-name=MISAWARyo en-aut-sei=MISAWA en-aut-mei=Ryo kn-aut-name=ŽO‘ò—Ç kn-aut-sei=ŽO‘ò kn-aut-mei=—Ç aut-affil-num=2 ORCID= affil-num=1 en-affil=Okayama Municipal Hosen Junior High School kn-affil=‰ªŽRŽs—§–Fò’†ŠwZ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=Žö‹Æ‚ƉƒëŠwK‚̘AŒg (coordination between classroom and home learning) kn-keyword=Žö‹Æ‚ƉƒëŠwK‚̘AŒg (coordination between classroom and home learning) en-keyword=Ž©ŒÈ’²®ŠwK (self-regulated learning) kn-keyword=Ž©ŒÈ’²®ŠwK (self-regulated learning) en-keyword=h‘è (homework) kn-keyword=h‘è (homework) en-keyword=Žö‹Æ‰ü‘P (lesson improvement) kn-keyword=Žö‹Æ‰ü‘P (lesson improvement) END start-ver=1.4 cd-journal=joma no-vol=18 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clipping closure length is a crucial factor for delayed bleeding after endoscopic papillectomy: a retrospective multicenter cohort study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Bleeding is a serious and frequent adverse event that occurs during and after endoscopic papillectomy (EP). Previous studies have highlighted the effectiveness of preventive clipping closure of the resection site in preventing post-EP bleeding. However, the optimal length of closure remained unclear.
Objectives: We aimed to clarify the optimal clipping length at the post-EP resection site to prevent delayed bleeding.
Design: This study was a multicenter retrospective cohort study.
] Methods: We retrospectively analyzed patients who were consecutively admitted to nine high-volume centers for EP between November 2003 and October 2023. The primary outcome was the frequency of delayed bleeding based on the closure length. The optimal closure length rate of the resected site to prevent delayed bleeding was determined using a receiver operating characteristic curve. Secondary outcomes were the incidence, treatment outcomes, and risk factors for post-EP delayed bleeding.
Results: A total of 130 patients who underwent EP were analyzed. Delayed bleeding was observed in 22 (17%) patients, occurring more frequently in cases without clipping closure than in those with clipping closure (28% (13/47) vs 11% (9/83); p = 0.014). Among 83 patients who underwent clipping closure, delayed bleeding occurred more frequently with a closure length rate <65% than in those with a closure rate >= 65% (25% (5/20) vs 6% (4/63); p = 0.019). Multivariate analysis showed that a closure rate <65% was the risk factor for delayed bleeding (odds ratio, 6.3; 95% confidence interval, 1.2-33; p = 0.030) in cases with clipping.
Conclusion: Clipping closure was effective in preventing delayed bleeding, and closure length rate >= 65% of the resected site significantly reduced post-EP delayed bleeding. en-copyright= kn-copyright= en-aut-name=FujiiYuki en-aut-sei=Fujii en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsumotoKazuyuki en-aut-sei=Matsumoto en-aut-mei=Kazuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OchiKiyoaki en-aut-sei=Ochi en-aut-mei=Kiyoaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HimeiHitomi en-aut-sei=Himei en-aut-mei=Hitomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SakakiharaIchiro en-aut-sei=Sakakihara en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UetaEijiro en-aut-sei=Ueta en-aut-mei=Eijiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ToyokawaTatsuya en-aut-sei=Toyokawa en-aut-mei=Tatsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HaradaRyo en-aut-sei=Harada en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OgawaTaiji en-aut-sei=Ogawa en-aut-mei=Taiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TomodaTakeshi en-aut-sei=Tomoda en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KatoHironari en-aut-sei=Kato en-aut-mei=Hironari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=SatoRyosuke en-aut-sei=Sato en-aut-mei=Ryosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=ObataTaisuke en-aut-sei=Obata en-aut-mei=Taisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=MatsumiAkihiro en-aut-sei=Matsumi en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=MiyamotoKazuya en-aut-sei=Miyamoto en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=UchidaDaisuke en-aut-sei=Uchida en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=HoriguchiShigeru en-aut-sei=Horiguchi en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=TsutsumiKoichiro en-aut-sei=Tsutsumi en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=OtsukaMotoyuki en-aut-sei=Otsuka en-aut-mei=Motoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Gastroenterology, Fukuyama City Hospital kn-affil= affil-num=4 en-affil=Department of Gastroenterology, Hiroshima City Hiroshima Citizens Hospital kn-affil= affil-num=5 en-affil=Department of Gastroenterology, Kagawa Prefectural Central Hospital kn-affil= affil-num=6 en-affil=Department of Gastroenterology, National Hospital Organization, Iwakuni Clinical Center kn-affil= affil-num=7 en-affil=Department of Gastroenterology, National Hospital Organization, Fukuyama Medical Center kn-affil= affil-num=8 en-affil=Department of Gastroenterology, Japanese Red Cross Okayama Hospital kn-affil= affil-num=9 en-affil=Department of Gastroenterology, Tsuyama Chuo Hospital kn-affil= affil-num=10 en-affil=Department of Gastroenterology, Okayama City Hospital kn-affil= affil-num=11 en-affil=Department of Gastroenterology, Okayama City Hospital kn-affil= affil-num=12 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=13 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=14 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=15 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=16 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=17 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=18 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=19 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= en-keyword=clipping closure kn-keyword=clipping closure en-keyword=delayed bleeding kn-keyword=delayed bleeding en-keyword=endoscopic papillectomy kn-keyword=endoscopic papillectomy END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=281 end-page=295 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Development Support a Child with Autism to Acquisition of Intersubjective Communication: Through the Environmental Setting of Play with Shared Positive Emotions kn-title=ASD Ž™‚É‚¨‚¯‚é‘ŠŒÝ“`’Bsˆ×‚ÌŠl“¾‚ð–ÚŽw‚µ‚½—V‚Ñ‚ð’†S‚Æ‚µ‚½ƒRƒ~ƒ…ƒjƒP[ƒVƒ‡ƒ“Žw“±@ƒ|ƒWƒeƒBƒu‚Èî“®‚Ì‹¤—L‚ð¶‚Ýo‚·—V‚т̊‹«Ý’è‚ð’Ê‚µ‚Ä en-subtitle= kn-subtitle= en-abstract=In this study, a play-based instruction was used to promote the acquisition of intersubjective communication in a special needs school for students with intellectual disabilities. The participant was a first-grade boy with autism. As a result, the boy began to show intersubjective communication and to respond to the teacher's instruction. It was suggested that four aspects of the play environment may have promoted the acquisition of intersubjective communication: 1) attractive toys, 2) play with the teacher through attractive toys, 3) intervention according to the developmental process of the target children's play, and 4) empathic involvement to encourage the affective sharing. kn-abstract=@Ž©•ÂƒXƒyƒNƒgƒ‰ƒ€ÇŽ™‚ÍC‘ŠŒÝ“`’Bsˆ×‚ÌŠl“¾‚É’x‚ꂪ‚ ‚邱‚Æ‚ªŽw“E‚³‚ê‚Ä‚¢‚éB–{Œ¤‹†‚Å‚ÍCŽ©•ÂƒXƒyƒNƒgƒ‰ƒ€Ç‚Ìf’f‚Ì‚ ‚é’m“IáŠQ“Á•ÊŽx‰‡ŠwZ¬Šw•”‚P”N¶’jŽ™‚ð‘ÎÛ‚ÉC‘ŠŒÝ“`’Bsˆ×‚ÌŠl“¾‚ð–ÚŽw‚µ‚ÄC—V‚Ñ‚ð’†S‚Æ‚µ‚½Žw“±‚ðs‚Á‚½B‚»‚ÌŒ‹‰ÊC‘ÎÛŽ™‚Ì—V‚Ñ‚ªuŠ´Šo‰^“®“I—V‚Ñvu‹@”\“I—V‚Ñv‚©‚çuÛ’¥“I—V‚ÑvuŽÐ‰ï“I—V‚Ñv‚ւƈÚs‚·‚é‚É”º‚¢C‘ŠŒÝ“`’Bsˆ×‚ªŒ©‚ç‚ê‚é‚悤‚É‚È‚Á‚½B‚Ü‚½C‹³Žt‚É‚æ‚é“­‚«Š|‚¯‚ւ̉ž“š‚àŒ©‚ç‚ê‚é‚悤‚É‚È‚èCƒ|ƒWƒeƒBƒu‚Èî“®‚Ì‹¤—L‚ª¶‚Ýo‚³‚ê‚â‚·‚¢—V‚т̊‹«Ý’肪C‘ŠŒÝ“`’Bsˆ×‚ÌŠl“¾‚É‚¨‚¢‚ÄŒø‰Ê“I‚Å‚ ‚Á‚½‚±‚Æ‚ªŽ¦´‚³‚ꂽB—V‚ъ‹«‚ɂ‚¢‚Ä‚ÍC1j–£—Í“I‚ÈŠß‹ïC2j–£—Í“I‚ÈŠß‹ï‚ð‰î‚µ‚½‹³Žt‚Æ‚Ì—V‚ÑC3j‘ÎÛŽ™‚Ì—V‚Ñ‚Ì”­’B’iŠK‚ɉž‚¶‚½‰î“üC4jî“®‚Ì‹¤—L‚𑣂·‹¤Š´“IŠÖ‚í‚è‚Ì‚S“_‚ª‘ŠŒÝ“`’Bsˆ×‚ÌŠl“¾‚𑣂µ‚½‰Â”\«‚ªl‚¦‚ç‚ꂽB en-copyright= kn-copyright= en-aut-name=KAKUHARAKeisuke en-aut-sei=KAKUHARA en-aut-mei=Keisuke kn-aut-name=ŠpŒ´‰À‰î kn-aut-sei=ŠpŒ´ kn-aut-mei=‰À‰î aut-affil-num=1 ORCID= en-aut-name=BANMarina en-aut-sei=BAN en-aut-mei=Marina kn-aut-name=”º^—¢“Þ kn-aut-sei=”º kn-aut-mei=^—¢“Þ aut-affil-num=2 ORCID= en-aut-name=TANJITakayuki en-aut-sei=TANJI en-aut-mei=Takayuki kn-aut-name=’OŽ¡Œh”V kn-aut-sei=’OŽ¡ kn-aut-mei=Œh”V aut-affil-num=3 ORCID= affil-num=1 en-affil=Tobi Special School kn-affil=‰ªŽRŒ§—§“Œ”õŽx‰‡ŠwZ affil-num=2 en-affil=Special School Affiliated with the Faculty of Education at Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆçŠw•”•‘®“Á•ÊŽx‰‡ŠwZ affil-num=3 en-affil=Institute of Human Sciences, University of Tsukuba kn-affil=’}”g‘åŠwlŠÔŒn en-keyword=Ž©•ÂƒXƒyƒNƒgƒ‰ƒ€Ç (a Child with Autism) kn-keyword=Ž©•ÂƒXƒyƒNƒgƒ‰ƒ€Ç (a Child with Autism) en-keyword=‘ŠŒÝ“`’Bsˆ× (Intersubjective Communication) kn-keyword=‘ŠŒÝ“`’Bsˆ× (Intersubjective Communication) en-keyword=î“®‚Ì‹¤—L (effective sharing) kn-keyword=î“®‚Ì‹¤—L (effective sharing) en-keyword=—V‚т̊‹«Ý’è (Setting of Play) kn-keyword=—V‚т̊‹«Ý’è (Setting of Play) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=267 end-page=279 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Examination of Practical Cases of Career Education to Promote Self-Understanding in Elementary School Students: Utilizing Character Strengths Intervention kn-title=Ž™“¶‚ÌŽ©ŒÈ—‰ð‚𑣂·ƒLƒƒƒŠƒA‹³ˆç‚ÌŽÀ‘HŽ–—á‚ÌŒŸ“¢@\‹­‚݉î“ü‚ðŠˆ—p‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract=This study explored the implementation of Character Strengths Intervention (CSI), rooted in positive psychology, to enhance self-awareness in career education for elementary school students. The intervention targeted 4th-grade students at a public elementary school, aiming to facilitate their recognition and utilization of character strengths in relation to future aspirations. Through structured lessons, students deepened their understanding of personal strengths and developed increased awareness of how to apply these attributes towards their future goals. Moreover, peer-focused activities designed to acknowledge individual strengths contributed to improved interpersonal relationships among students. However, challenges persist, including the need for comprehensive systematic and developmental planning of career education across the entire school, as well as providing tailored support for students who find it difficult to identify and leverage their unique strengths. kn-abstract=–{Œ¤‹†‚Å‚ÍCŒö—§¬ŠwZ4”N¶‚ð‘ÎÛ‚ÉCƒLƒƒƒŠƒA‹³ˆç‚É‚¨‚¯‚鎩ŒÈ—‰ð”\—͂̈笂ð–Ú“I‚Æ‚µCƒ|ƒWƒeƒBƒuS—Šw‚ÉŠî‚­«Ši“Á«“I‹­‚݉î“ü (Character Strengths InterventionFCSI) ‚Æ«—ˆ‚Ì–²‚ɂ‚¢‚Ä‚ÌŠwK‚ðŠÖ˜A•t‚¯‚½Šw‹‰Šˆ“® (‚R) ‚ÌŽö‹Æ‚ðs‚Á‚½B–{ŽÀ‘H‚ð’Ê‚µ‚ÄCŽ™“¶‚ÍŽ©•ª‚Ì‹­‚Ý‚ð—‰ð‚µC‚»‚ê‚ð«—ˆ‚ÉŠˆ‚©‚»‚¤‚Æ‚·‚éˆÓŽ¯‚ª‚‚Ü‚é‚Æ‚Æ‚à‚ÉCŒÝ‚¢‚Ì‹­‚Ý‚ð”F‚߇‚¤Šˆ“®‚É‚æ‚Á‚ÄŽ™“¶“¯Žm‚ÌŠÖŒW«‚Ì\’z‚ª‘£i‚³‚ꂽBˆê•û‚ÅCŠwZ‘S‘̂ł̃LƒƒƒŠƒA‹³ˆç‚ÌŒn“«‚Æ”­“W«‚ÌŒŸ“¢C‹­‚Ý‚ÌŠˆ—p‚ª“‚¢Ž™“¶‚ւ̌•ʎx‰‡‚Ì•K—v«‚ª¡Œã‚̉ۑè‚Æ‚µ‚ÄŽw“E‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=YOSHIKAWAShinji en-aut-sei=YOSHIKAWA en-aut-mei=Shinji kn-aut-name=‹gìL“ñ kn-aut-sei=‹gì kn-aut-mei=L“ñ aut-affil-num=1 ORCID= en-aut-name=ISODAKouhei en-aut-sei=ISODA en-aut-mei=Kouhei kn-aut-name=ˆé“c_•½ kn-aut-sei=ˆé“c kn-aut-mei=_•½ aut-affil-num=2 ORCID= en-aut-name=IZUMITsuguyuki en-aut-sei=IZUMI en-aut-mei=Tsuguyuki kn-aut-name=ˆÉZŒps kn-aut-sei=ˆÉZ kn-aut-mei=Œps aut-affil-num=3 ORCID= affil-num=1 en-affil=Uwanari Elementary School kn-affil=‘q•~Žs—§ã¬¬ŠwZ affil-num=2 en-affil=Uwanari Elementary School kn-affil=‘q•~Žs—§ã¬¬ŠwZ affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=ƒLƒƒƒŠƒA‹³ˆç (Career Education) kn-keyword=ƒLƒƒƒŠƒA‹³ˆç (Career Education) en-keyword=Ž©ŒÈ—‰ð (Self-awareness) kn-keyword=Ž©ŒÈ—‰ð (Self-awareness) en-keyword=«Ši“Á«“I‹­‚Ý (Character Strengths) kn-keyword=«Ši“Á«“I‹­‚Ý (Character Strengths) en-keyword=Šw‹‰Šˆ“® (‚R) (Classroom Activities (3)) kn-keyword=Šw‹‰Šˆ“® (‚R) (Classroom Activities (3)) en-keyword=Ž™“¶ (Children) kn-keyword=Ž™“¶ (Children) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=251 end-page=265 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Bridging the Gap: Outcomes and Challenges of a Collaborative Start Curriculum for Seamless Transition to Elementary School kn-title=¬ŠwZ‚Ö‚ÌŠŠ‚ç‚©‚ȈÚs‚ðŽx‚¦‚éƒXƒ^[ƒgƒJƒŠƒLƒ…ƒ‰ƒ€‹¤“¯•Ò¬ƒvƒƒWƒFƒNƒg‚̬‰Ê‚Ɖۑè en-subtitle= kn-subtitle= en-abstract=In this practice, a joint curriculum development project was launched to ease the transition for children in the gbridge periodh from age five to first grade, involving five discussions between kindergarten and elementary school teachers. Participants reflected on these discussions, and the content was analyzed. (1) A screening sheet to identify children who gcause concernh helped clarify differences in observations, leading to a shared understanding of child perceptions. (2) Teachers recognized differences in their views of children and education, improving their attitudes toward compromise and increasing awareness of the need to smooth the transition. However, an overloaded elementary school curriculum was noted, limiting the flexible application of the start curriculum and hindering child-centered education. kn-abstract=–{ŽÀ‘H‚Å‚ÍC‚TÎŽ™‚©‚笊w‚P”N¶‚Ìu‰Ë‚¯‹´Šúv‚ÌŠŠ‚ç‚©‚ȈÚs‚ÉÅ“_‚ð“–‚Ä‚½ƒXƒ^[ƒgƒJƒŠƒLƒ…ƒ‰ƒ€‹¤“¯•Ò¬ƒvƒƒWƒFƒNƒg‚𗧂¿ã‚°C—c’t‰€‚ƬŠwZ‚Ì‹³ˆõ‚ªW‚Ü‚Á‚Ä‚T‰ñ‚̘b‡‚¢‚ðs‚Á‚½B–{ƒvƒƒWƒFƒNƒg‚ð•]‰¿‚·‚邽‚ß‚ÉCŽQ‰ÁŽÒ‚ɘb‡‚¢‚ÌU•Ô‚è‚ð‘‚¢‚Ä‚à‚ç‚¢C‚»‚Ì“à—e‚ðŒŸ“¢‚µ‚½B¬‰Ê‚Æ‚µ‚ÄC‡@ƒXƒNƒŠ[ƒjƒ“ƒOƒV[ƒg‚ðŽg‚Á‚ÄCu‹C‚É‚È‚évŽq‹Ÿ‚ð’Šo‚µCŒ©Žæ‚è‚̈Ⴂ‚ð‰ÂŽ‹‰»‚·‚邱‚Æ‚ÅC‘ŠŒÝ‚ÌŽq‹ŸŠÏ‚ɂ‚¢‚Ä‹¤’Ê—‰ð‚ð}‚邱‚Æ‚ª‚Å‚«‚½B‡A—c’t‰€‚ƬŠwZC‘o•û‚Ì‹³ˆõ‚ªŒÝ‚¢‚ÌŽq‹ŸŠÏE‹³ˆçŠÏ‚̈Ⴂ‚ð—‰ð‚µC•à‚ÝŠñ‚낤‚Æ‚·‚éŽp¨‚âZŽíŠÔ‚ÌÚ‘±‚ð‚æ‚芊‚ç‚©‚É‚µ‚悤‚Æ‚·‚éˆÓŽ¯‚ÌŒüオŠm”F‚³‚ꂽBˆê•ûC‰Û‘è‚Æ‚µ‚ÄCƒXƒ^[ƒgƒJƒŠƒLƒ…ƒ‰ƒ€‚Ì_“î‚ȉ^—p‚⬊wZ‹³ˆç‚É‚¨‚¯‚éŽq‹ŸŽå‘Ì‚Ì‹³ˆç‚ÌŽÀŒ»‚ð–W‚°‚鋳ˆç‰Û’ö‚̉ßÏÚó‘Ô‚Ì–â‘肪Žw“E‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=OKURAHisashi en-aut-sei=OKURA en-aut-mei=Hisashi kn-aut-name=‘å‘q®Žu kn-aut-sei=‘å‘q kn-aut-mei=®Žu aut-affil-num=1 ORCID= en-aut-name=MATSUINoriko en-aut-sei=MATSUI en-aut-mei=Noriko kn-aut-name=¼ˆä‹IŽq kn-aut-sei=¼ˆä kn-aut-mei=‹IŽq aut-affil-num=2 ORCID= en-aut-name=IZUMITsuguyuki en-aut-sei=IZUMI en-aut-mei=Tsuguyuki kn-aut-name=ˆÉZŒps kn-aut-sei=ˆÉZ kn-aut-mei=Œps aut-affil-num=3 ORCID= affil-num=1 en-affil=Hayashima Kindergarten kn-affil=‘“‡’¬—§‘“‡—c’t‰€ affil-num=2 en-affil=Hayashima Kindergarten kn-affil=‘“‡’¬—§‘“‡—c’t‰€ affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=‰Ë‚¯‹´ƒvƒƒOƒ‰ƒ€ (Bridge Program) kn-keyword=‰Ë‚¯‹´ƒvƒƒOƒ‰ƒ€ (Bridge Program) en-keyword=ƒXƒ^[ƒgƒJƒŠƒLƒ…ƒ‰ƒ€ (Start Curriculum) kn-keyword=ƒXƒ^[ƒgƒJƒŠƒLƒ…ƒ‰ƒ€ (Start Curriculum) en-keyword=ƒXƒNƒŠ[ƒjƒ“ƒOƒV[ƒg (Screening Sheet) kn-keyword=ƒXƒNƒŠ[ƒjƒ“ƒOƒV[ƒg (Screening Sheet) en-keyword=ƒJƒŠƒLƒ…ƒ‰ƒ€EƒI[ƒo[ƒ[ƒh (Curriculum Overload) kn-keyword=ƒJƒŠƒLƒ…ƒ‰ƒ€EƒI[ƒo[ƒ[ƒh (Curriculum Overload) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=235 end-page=249 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Practical Research on Nurturing the Next Generation of Classical Japanese Instrument Music That Connects the Local and the Global Community (1): Analysis of External Evaluations of the gOkayama International Classical Japanese Instruments Student Festivalh kn-title=’nˆæŽÐ‰ï‚ƃOƒ[ƒoƒ‹‚ð‚‚Ȃ®˜aŠyŠí‰¹ŠyŽŸ¢‘ãˆç¬‚ÌŽÀ‘HŒ¤‹†i‚Pj@u‚¨‚©‚â‚Ü‘Û˜aŠyŠíŠw¶ƒtƒFƒXƒeƒBƒoƒ‹vŠO“I•]‰¿‚Ì•ªÍ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–{e‚Å‚ÍCu˜aŠyŠí‰¹Šy‹y‚Ñ‹³ˆç‚Ì‹’“_‚­‚è‚ÌŽÀ‘HŒ¤‹†v‚̈êŠÂ‚Æ‚µ‚ÄŠJµ‚½u‚¨‚©‚â‚Ü‘Û˜aŠyŠíŠw¶ƒtƒFƒXƒeƒBƒoƒ‹v‚ÌŽæ‚è‘g‚݂ɂ‚¢‚ÄC‚»‚ÌŠT—v‚ð•ñ‚·‚é‚Æ‚Æ‚à‚ÉCŠO“I•]‰¿‚Æ‚µ‚Äu‚¨‚©‚â‚Ü‘Û˜aŠyŠíŠw¶ƒtƒFƒXƒeƒBƒoƒ‹ƒRƒ“ƒT[ƒgvI‰‰Œã‚ÉŽÀŽ{‚µ‚½ˆê”Ê—ˆêŽÒ‘ÎÛ‚ÌŽ¿–⎆’²¸‹y‚уtƒFƒXƒeƒBƒoƒ‹‚ðŽQŠÏ‚µ‚½‰ªŽRŒ§“à‚ÌŠwZŠÖŒWŽÒ‘ÎÛ‚ÌŽ¿–⎆’²¸‚ðŽæ‚èã‚°CˆÓ‹`‚Ɖۑè‚ɂ‚¢‚ÄŒŸ“¢‚µ‚½B
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kn-title=’†ŠwZ‰Æ’ë‰È‚É‚¨‚¯‚é‚—îŠúŠwK‚ÌŽÀ‘H@\ƒ‰ƒCƒtƒR[ƒX‚Ì’†‚Å‚—îŠú‚ðl‚¦‚é\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–{Œ¤‹†‚Å‚ÍC’†ŠwZ‰Æ’ë‰È‚É‚¨‚¯‚é‚—îŠúŠwK‚ÌŽö‹ÆŽÀ‘H‚ð’Ê‚µ‚ÄC’†Šw¶‚ª‚—îŠú‚ðŽ©‚ç‚̃‰ƒCƒtƒR[ƒX‚Ì’†‚Ål‚¦‚邱‚Æ‚ª‚Å‚«‚é‚©‚𖾂炩‚É‚·‚邱‚Æ‚ð–Ú“I‚Æ‚µC’†Šw¶‚ð‘ÎÛ‚É‚—îŽÒC‚—îŠúŠwK‚ðŽÀ‘H‚µ‚½B’†ŠwZ‰Æ’ë‰È‚É‚¨‚¯‚é‚—îŽÒ‚â‚—îŠú‚ÉŠÖ˜A‚·‚éŠwK“à—e‚ðŠm”F‚·‚邽‚ßCw’†ŠwZŠwKŽw“±—v—Ìi•½¬29”NŽ¦j‰ðà‹ZpE‰Æ’ë•Òx‚Ɖƒë‰È‚Ì‹³‰È‘‚ð•ªÍ‚µ‚½B’†Šw¶‚ª‚—îŽÒC‚—îŠú‚ÉŠÖ‚µ‚ÄŽ©•ª‚̃‰ƒCƒtƒR[ƒX‚̈ꕔ‚Æ‚µ‚Äl‚¦‚邱‚Æ‚ª‚Å‚«‚é‚悤‚ÉŠwKŽw“±ˆÄ‚ð쬂µC‰ªŽRŒ§“à‚ÌT’†ŠwZ3”N¶‚ð‘ÎÛ‚ÉŽö‹Æ‚ðs‚Á‚½BŽö‹ÆŽÀ‘H‚ÌŒ‹‰ÊCŠwK‚Ì[‚Ü‚è‚ðŠ´‚¶‚½‚Ɖñ“š‚µ‚½’†Šw¶‚ª‘½‚­C‚—îŠú‚ð«—ˆ‚ÌŽ©‚ç‚̃‰ƒCƒtƒR[ƒX‚Ì’†‚Ål‚¦‚ç‚ê‚é‚悤‚É‚È‚Á‚½’†Šw¶‚à­‚È‚­‚È‚¢‚±‚Æ‚ðŠm”F‚Å‚«‚½B‚µ‚©‚µC‚—îŽÒ‚ÉŠÖ‚·‚éŠwK‚ð‚æ‚è–]‚Þ’†Šw¶‚ª”¼”‚ð‰º‰ñ‚èC’†Šw¶‚ªX‚È‚éŠwK‚̈ӗ~‚â‹»–¡‚ðŽ‚Ä‚é‚悤‚ÈŠwK•û–@‚ÌH•v‚ª•K—v‚Å‚ ‚邱‚Æ‚à–¾‚ç‚©‚É‚È‚Á‚½B en-copyright= kn-copyright= en-aut-name=TAKATAMihoko en-aut-sei=TAKATA en-aut-mei=Mihoko kn-aut-name=‚“c…•äŽq kn-aut-sei=‚“c kn-aut-mei=…•äŽq aut-affil-num=1 ORCID= en-aut-name=LEEKyoungwon en-aut-sei=LEE en-aut-mei=Kyoungwon kn-aut-name=—›ûm•Q kn-aut-sei=—› kn-aut-mei=ûm•Q aut-affil-num=2 ORCID= affil-num=1 en-affil=Student At Graduate School of Education, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@¶ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=‚—îŽÒ kn-keyword=‚—îŽÒ en-keyword=‚—îŠú kn-keyword=‚—îŠú en-keyword=’†ŠwZ‰Æ’ë‰È kn-keyword=’†ŠwZ‰Æ’ë‰È en-keyword=ŠwKŽw“±—v—Ì kn-keyword=ŠwKŽw“±—v—Ì en-keyword=‹³‰È‘ kn-keyword=‹³‰È‘ en-keyword=Elderly (Aging) kn-keyword=Elderly (Aging) en-keyword=junior High School Technology-Home Economics (Home Economics) kn-keyword=junior High School Technology-Home Economics (Home Economics) en-keyword=Courses of Study Textbooks kn-keyword=Courses of Study Textbooks END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=207 end-page=218 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Lesson Structure of Elementary Social Studies Law-Related Education Focusing on the Concept of Contract: Through the Designing of a Unit on Production and Sales in the Third Grade kn-title=Œ_–ñŠT”O‚É’–Ú‚µ‚½¬ŠwZŽÐ‰ï‰È–@‹³ˆç‚ÌŽö‹Æ\¬@\‘æ‚RŠw”N‚̶ŽY‚â”Ì”„‚ÉŠÖ‚·‚é’PŒ³‚ÌŠJ”­‚ð’Ê‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract=This paper clarifies the Lesson Theory of Law-Related Education as citizenship education in elementary social studies, clarifies the Theory of lesson structure, and develops a unit on sales work in the middle grades. Research has been conducted in elementary Law-Related Education based on the theory of developmental psychology, but systematization as elementary social studies has not been promoted. In the elementary school social studies, the content of the third grade "about the work of production and sales found in the community" is set. Sales equally involve legal issues such as sales contracts. this paper suggests an elementary social studies unit using a supermarket as a teaching material, based on Law-Related Education research accumulated in social studies education research to date. kn-abstract=@–{˜_•¶‚ÍA¬ŠwZŽÐ‰ï‰È‚É‚¨‚¯‚éŽs–¯«‹³ˆç‚Æ‚µ‚Ä‚Ì–@‹³ˆç‚Ì‚ ‚è•û‚ðŒŸ“¢‚µA‚»‚ÌŽö‹Æ\¬Œ´—‚𖾂炩‚É‚µ‚½‚¤‚¦‚ÅA’†Šw”N‚Ì‹³ˆç“à—e‚Å‚ ‚é”Ì”„‚ÌŽdŽ–‚ÉŠÖ‚·‚é’PŒ³ŠJ”­‚ðs‚¤‚à‚Ì‚Å‚ ‚éB‚±‚ê‚܂ŬŠwZ–@‹³ˆç‚Å‚ÍA”­’BS—Šw‚̘_‚ðŠî‚É‚µ‚È‚ª‚猤‹†‚ªi‚ß‚ç‚ê‚Ä‚«‚½‚ªA¬ŠwZŽÐ‰ï‰È–@‹³ˆç‚Æ‚µ‚Ä‚Ì‘ÌŒn“I‚ÈŒ¤‹†‚Í\•ª‚Å‚Í‚È‚©‚Á‚½B¬ŠwZ‘æ‚RŠw”N‚̎Љï‰È‚Å‚ÍA‘æ‚RŠw”Nu’nˆæ‚É‚Ý‚ç‚ê‚鶎Y‚â”Ì”„‚ÌŽdŽ–‚ɂ‚¢‚Äv‚Ì“à—e‚ªÝ’肳‚ê‚Ä‚¢‚éB²“¡‚̓X[ƒp[ƒ}[ƒPƒbƒg‚ð‹³Þ‚Æ‚µ‚ĬŠwZŽÐ‰ï‰È‚ÅŒoÏŠT”O‚ðŒ`¬‚·‚éŽö‹Æ‚ðŠJ”­‚µA‚»‚Ì—LŒø«‚ðŒŸØ‚µ‚½Bˆê•û‚ÅA”Ì”„‚É‚Í”„”ƒŒ_–ñ‚̂悤‚È–@“I–â‘è‚à”­¶‚·‚éB–{˜_•¶‚Å‚ÍA‚±‚ê‚܂ł̎Љï‰È‹³ˆçŒ¤‹†‚É‚¨‚¢‚Ä’~Ï‚³‚ê‚Ä‚«‚½–@‹³ˆç˜_‚≿’lŠÏŒ`¬˜_‚̬‰Ê‚𓥂܂¦AƒX[ƒp[ƒ}[ƒPƒbƒg‚ð‹³Þ‚Æ‚µ‚½¬ŠwZŽÐ‰ï‰È’PŒ³ŠJ”­‚ðs‚¤B en-copyright= kn-copyright= en-aut-name=MIYAMOTOAyuha en-aut-sei=MIYAMOTO en-aut-mei=Ayuha kn-aut-name=‹{–{‚ ‚ä‚Í kn-aut-sei=‹{–{ kn-aut-mei=‚ ‚ä‚Í aut-affil-num=1 ORCID= en-aut-name=KUWABARAToshinori en-aut-sei=KUWABARA en-aut-mei=Toshinori kn-aut-name=ŒKŒ´•q“T kn-aut-sei=ŒKŒ´ kn-aut-mei=•q“T aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Humanities and Social Sciences, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È”ŽŽmŒãŠú‰Û’ö affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=–@‹³ˆç (Law-Related Education) kn-keyword=–@‹³ˆç (Law-Related Education) en-keyword=‰“™‹³ˆç (Elementary School Education) kn-keyword=‰“™‹³ˆç (Elementary School Education) en-keyword=¬ŠwZŽÐ‰ï‰È (Social Studies) kn-keyword=¬ŠwZŽÐ‰ï‰È (Social Studies) en-keyword=–¯–@ŠwK (Civil Law Education) kn-keyword=–¯–@ŠwK (Civil Law Education) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=191 end-page=205 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Prevention of Apathy in High School Students Perspective on Time Management and Future Prospects kn-title=ƒAƒpƒV[ŒXŒü‚©‚ç‚Ý‚½‚Z¶‚Ì–³‹C—Í‚Ì—\–h‚ɂ‚¢‚Ä@\ƒ^ƒCƒ€ƒ}ƒlƒWƒƒ“ƒgC«—ˆ“W–]‚Æ‚ÌŠÖŒW‚ð’Ê‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract=@According to the Ministry of Education in Japan (2023), apathy is the leading cause of truancy among high school students, with the percentage of nonattendance at 40%. Therefore, this study aimed to examine the prevention of apathy among high school students. Apathy among college students has been examined as a propensity for apathy. This study presupposes that apathy among high school students is also associated with a propensity for apathy. Two hundred and nineteen high school students were participated in this research. We assumed time management (TM) and future prospects (self-fulfillment, goal-directedness, and hopefulness) would be preventive factors against apathetic tendencies for them. The study findings indicate that self-fulfillment may significantly reduce apathy, with hopefulness also contributing to reducing apathy. Additionally, the characteristics of apathy tendency, specifically lack of self, were found to be differently related to students' TM skills. In other words, the findings suggest that goal-directedness may alleviate apathy among students struggling with TM. kn-abstract=@•s“oZ‚̎傽‚é—vˆö‚Ì1ˆÊ‚Íu–³‹C—ÍE•sˆÀv‚Å40.0%‚ðè‚ß‚éi•¶•”‰ÈŠwÈC2023jB‚±‚Ì‚±‚Æ‚ÍC•s“oZ‚Å‚È‚¢¶“k‚Ì’†‚É‚àC–³‹C—Í‚ðŠ´‚¶‚Ä‚¢‚鶓k‚ª‚©‚È‚è‚¢‚邱‚Æ‚ðŽ¦´‚µ‚Ä‚¢‚éB‚»‚±‚Å–{Œ¤‹†‚ÍC‚Z¶‚Ì–³‹C—Í‚Æ‚»‚Ì—\–h‚ɂ‚¢‚ÄŒŸ“¢‚·‚éB–³‹C—Í‚ÍC‘åŠw¶‚ð‘ÎۂɃAƒpƒV[ŒXŒü‚Æ‚µ‚ÄŒŸ“¢‚³‚ê‚Ä‚«‚½B‚»‚±‚Å‚Z¶‚Ì–³‹C—Í‚ðƒAƒpƒV[ŒXŒü‚Æ‚µ‚Ä‘¨‚¦C‰Á‚¦‚Ä‚»‚ê‚ð—\–h‚·‚é‚à‚̂ɂ‚¢‚Ä‚à•¹‚¹‚ÄŒŸ“¢‚µ‚½B—\–h–@‚ÌŒó•â‚Æ‚µ‚ÄCƒ^ƒCƒ€ƒ}ƒlƒWƒƒ“ƒgiˆÈ‰ºCTMj‚Æ«—ˆ“W–]iŒ»Ý‚Ì[ŽÀŠ´E–Ú•WŽwŒü«EŠó–]j‚ð‘z’肵C‚Z¶219–¼‚ð‘ÎÛ‚ÉC‚±‚ê‚ç‚ÌŠÖŒW‚ðŒŸ“¢‚µ‚½B•ªÍ‚ÌŒ‹‰ÊC–³‹C—Í‚ð’ጸ‚·‚é‚Ì‚ÍCŒ»Ý‚Ì[ŽÀŠ´CŠó–]‚Å‚ ‚èC“Á‚É‘OŽÒ‚ª—LŒø‚Å‚ ‚é‰Â”\«‚ðŽ¦‚¹‚½Bˆê•û‚ÅCƒAƒpƒV[ŒXŒü‚ÌŽ©•ª‚Ì‚È‚³‚Å‚ÍCTM ‚̃^ƒCƒv‚É‚æ‚Á‚ĈقȂéŠÖŒW‚ª‚Ý‚ç‚ꂽB‚‚܂èCTM ‚ª‹êŽè‚ȶ“k‚Å‚ÍCŠó–]‚æ‚è‚àC–Ú‘O‚Ì–Ú•W‚É–Ú‚ðŒü‚¯‚邱‚Æ‚ª–³‹C—Í‚ð’ጸ‚Å‚«‚é‰Â”\«‚ªŽ¦´‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=ASADAAsuka en-aut-sei=ASADA en-aut-mei=Asuka kn-aut-name=–ƒ“c–¾“ú kn-aut-sei=–ƒ“c kn-aut-mei=–¾“ú aut-affil-num=1 ORCID= en-aut-name=AOKITazuko en-aut-sei=AOKI en-aut-mei=Tazuko kn-aut-name=–ؑ½ŽõŽq kn-aut-sei=Â–Ø kn-aut-mei=‘½ŽõŽq aut-affil-num=2 ORCID= affil-num=1 en-affil=KANKO GAKUSEIFUKU CO., LTD. kn-affil=›ŒöŠw¶•ž affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ@‹³Žö en-keyword=‚Z¶ (High School Students) kn-keyword=‚Z¶ (High School Students) en-keyword=–³‹C—Í kn-keyword=–³‹C—Í en-keyword=ƒAƒpƒV[ŒXŒü (Apathy tendency) kn-keyword=ƒAƒpƒV[ŒXŒü (Apathy tendency) en-keyword=ƒ^ƒCƒ€ƒ}ƒlƒWƒƒ“ƒg (Time Management) kn-keyword=ƒ^ƒCƒ€ƒ}ƒlƒWƒƒ“ƒg (Time Management) en-keyword=«—ˆ“W–] (Future Prospect) kn-keyword=«—ˆ“W–] (Future Prospect) en-keyword=Prevention kn-keyword=Prevention END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=179 end-page=190 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Current Trends and Future Issues Related to Songfs speed in the Preschool-Elementary Cooperated Education Research kn-title=—cŽ™‰Ì¥‹È‚Ì‘¬“xŠ´‚ÌŒXŒü‚Ɖۑè en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–{Œ¤‹†‚Å‚ÍC‰¹Šy‹³ˆç“IŠÏ“_‚©‚ç—cŽ™‰Ì¥‹È‚Ì‘I’è‚Ì‚ ‚è•û‚ðŒŸ“¢‚µ‚½B‚»‚ÌÛC¬ŠwZ‚̉¹Šy‹³ˆç‚ʼn̥‹¤’ʉۑè‚Æ‚µ‚Ä‹“‚°‚ç‚ê‚Ä‚«‚½‹³Þ‚ð”äŠr‘ÎÛ‚Æ‚µC‚»‚ÌŒXŒü‚Ɖۑè‚ðlŽ@‚·‚éB‚P‚–ڂ͋Ȃ̑¬“xŠ´‚É‚¨‚¢‚ĉ̥‹¤’Ê‹³Þ‚Æ‘I’è•p“x‚Ì‚‚¢—cŽ™‰Ì¥‹È‚Ì•½‹Ï“I‚È‘¬“x‚É‚¨‚¢‚ÄC‚Ç‚Ì’ö“x‚Ì·‚ª‚ ‚é‚Ì‚©‚Æ‚¢‚¤’²¸‚ðs‚Á‚½B‚Q‚–ڂÍC—c’t‰€‚ƬŠwZ‰¹Šy‰È‚Å‹¤’Ê‚µ‚Ä—p‚¢‚ç‚ê‚鋳ދȂÌì‹È‚³‚ꂽ”N‘ã‚̈Ⴂ‚ɂ‚¢‚Ä–¾‚ç‚©‚É‚µ‚½B‚±‚Ì‚Q‚‚̒²¸‚ð—p‚¢‚ÄC‰Ì¥‹¤’ʉۑè‚É‘I’肳‚ê‚Ä‚¢‚é‹È‚Ì‘¬“xŠ´‚©‚猻‘ã‚ÌŽq‚Ç‚à‚̉̂̑¬“xŠ´‚ÌŒXŒü‚𖾂炩‚É‚µ‚½B‚±‚ÌŒ‹‰Ê‚©‚ç—c’t‰€‹³ˆç‚É‚¨‚¯‚é—cŽ™‰Ì¥‹È‚̃`ƒƒ[ƒg‚ð쬂·‚邱‚Æ‚É‚æ‚Á‚ÄC“`““I‚ɉ̂¢Œp‚ª‚ê‚Ä‚«‚½—cŽ™‰Ì¥‹È‚ÌÄl‚̉”\«‚ðŽ¦‚µ‚½B en-copyright= kn-copyright= en-aut-name=TAKASUHiromi en-aut-sei=TAKASU en-aut-mei=Hiromi kn-aut-name=ûü{—T”ü kn-aut-sei=ûü{ kn-aut-mei=—T”ü aut-affil-num=1 ORCID= affil-num=1 en-affil=Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=—c•Û¬˜AŒg (Preschool-elementary cooperation) kn-keyword=—c•Û¬˜AŒg (Preschool-elementary cooperation) en-keyword=Žq‹Ÿ‚̉̂̑¬“xŠ´ (Childrenfs Song speed) kn-keyword=Žq‹Ÿ‚̉̂̑¬“xŠ´ (Childrenfs Song speed) en-keyword=Žq‹Ÿ‚̉̕¶‰» (Childrenfs singing culture) kn-keyword=Žq‹Ÿ‚̉̕¶‰» (Childrenfs singing culture) en-keyword=“`“‰¹Šy (Japanese traditional song materials) kn-keyword=“`“‰¹Šy (Japanese traditional song materials) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=163 end-page=177 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Climate and Songs of Spring/May Around Germany (Part ‡U): A Report of an Interdisciplinary Lesson Practice at the University Leading to the Understanding of Heterogeneous Others kn-title=ƒhƒCƒc•t‹ß‚ÌtE‚TŒŽ‚Ì‹CŒó‚ƉÌi‚»‚Ì‚QjFˆÙŽ¿‚È‘¼ŽÒ‚Ö‚Ìo‰ï‚¢‚𑣂·‘åŠw‚Å‚ÌŠwÛ“IŽö‹Æ‚ÌŽÀ‘H en-subtitle= kn-subtitle= en-abstract=An interdisciplinary lesson practice for the university students leading to the understanding of heterogeneous others was made on a topic of climate and songs of "spring/May" around Germany, as a continuing study of Kato et al. (2023b). In the lesson practice, details of the climate and seasonal cycle around Germany, in association with the seasonal feeling of the special season May, were firstly presented. Then, several German lieder, a film music, etc. were appreciated, paying attention to the relation between expressions of the songs and their climate backgrounds. It seems that the students were able to realize the characteristic expressions of the songs relating to the seasonal feeling of "the special season May" around Germany, mainly from the song lyrics, although how to promote further the students' deepening of such perception including musical expressions themselves is a remaining problem. kn-abstract=@ƒhƒCƒc•t‹ß‚ÌutE5ŒŽv‚Ì‹CŒó‚Ɖ̂̕\Œ»‚ÌŠwÛ“IŠwK‚ð’Ê‚µ‚ÄuˆÙŽ¿‚È‘¼ŽÒv‚Ö‚Ìo‰ï‚¢‚𑣂·‹³‰È‰¡’f“IŽö‹Æ‚ð‘åŠw‚Ås‚Á‚½BŽö‹Æ‚Å‚ÍCƒhƒCƒc•t‹ß‚É‚¨‚¯‚éutE5ŒŽv‚Ì‹Gߊ´‚Ì2‚‚̑¤–ÊC‚·‚È‚í‚¿uŒµ‚µ‚¢“~‚ðŒo‚Ä„‚è—ˆ‚é“Á•Ê‚ÈŠì‚Ñv‚âu‚·‚®‚ɉ߂¬‹Ž‚鎊•Ÿ‚ÌuŠÔ‚Ì™R‚³v‚ÉŠÖ˜A‚µ‚½‹CŒó‚Ì“Á’¥‚ðu‹`‚·‚é‚Æ‹¤‚ÉC‚»‚ê‚ç‚Ì‹Gߊ´‚ª•\Œ»‚³‚ꂽƒhƒCƒc‰Ì‹È‚â‰f‰æs‰ï‹c‚Í—x‚ét‚ÌŽå‘è‰Ìq‚½‚¾ˆê“x‚¾‚¯r“™‚ÌŠÓÜ‚ðs‚¢Cì•i‚Ì”wŒi‚É‚ ‚é‹CŒó‚Ɖ¹Šy•\Œ»‚ÌŠÖ‚è‚ɃAƒvƒ[ƒ`‚µ‚½B‚»‚ÌŒ‹‰ÊCì•i‚̉̎Œ‚ðŽå‚Ȏ肪‚©‚è‚ÉC‹CŒó‚â‹Gߊ´‚Ɖ¹Šy•\Œ»‚ÌŠÖ‚è‚ðŠT‚Ë‘¨‚¦‚邱‚Æ‚ª‚Å‚«‚½B]‚Á‚ÄC–{ŽÀ‘H‚ªuˆÙŽ¿‚È‘¼ŽÒv‚Ì‘¶Ý‚ðŽÀŠ´‚·‚é‹@‰ï‚ɂȂ蓾‚½‚Æ‚¢‚¦‚éBˆê•ûCu5ŒŽv‚Æ‚¢‚¤ˆêŒê‚É‹Ãk‚³‚ꂽƒhƒCƒc•t‹ß‚È‚ç‚Å‚Í‚Ì[‚¢“à—e‚ðu‰ä‚ªŽ–v‚Æ‚µ‚Ä‚æ‚è‹­‚­ŽÀŠ´‚·‚邽‚ß‚É‚ÍC‰ÌŽŒ‚Í‚à‚Æ‚æ‚艹Šy“I•\Œ»‚Æ‚Ì—‚Ý‚ðˆÓŽ¯‚µ‚½‘¨‚¦•ûC’ñŽ¦‚Ì•K—v«‚ªŽ¦´‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=KATOKuranoshin en-aut-sei=KATO en-aut-mei=Kuranoshin kn-aut-name=‰Á“¡“àåUi kn-aut-sei=‰Á“¡ kn-aut-mei=“àåUi aut-affil-num=1 ORCID= en-aut-name=NAGAOKAIsao en-aut-sei=NAGAOKA en-aut-mei=Isao kn-aut-name=’·‰ªŒ÷ kn-aut-sei=’·‰ª kn-aut-mei=Œ÷ aut-affil-num=2 ORCID= en-aut-name=KATOHaruko en-aut-sei=KATO en-aut-mei=Haruko kn-aut-name=‰Á“¡°Žq kn-aut-sei=‰Á“¡ kn-aut-mei=°Žq aut-affil-num=3 ORCID= en-aut-name=OTANIKazuo en-aut-sei=OTANI en-aut-mei=Kazuo kn-aut-name=‘å’J˜a’j kn-aut-sei=‘å’J kn-aut-mei=˜a’j aut-affil-num=4 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=3 en-affil=Faculty of Education, Gifu Shotoku Gakuen University (Former affiliation) kn-affil=Œ³@Šò•Œ¹“¿Šw‰€‘åŠw‹³ˆçŠw•” affil-num=4 en-affil=TV Setouchi Broadcasting Co., LTD. kn-affil=ƒeƒŒƒr‚¹‚Æ‚¤‚¿iŠ”j en-keyword=‹CŒó‚Ɖ¹Šy (Climate and music) kn-keyword=‹CŒó‚Ɖ¹Šy (Climate and music) en-keyword=ƒhƒCƒc•t‹ß‚ÌtE5ŒŽ‚Ì‹CŒó‚Æ‹Gߊ´ (Climate and seasonal feeling in spring/May around Germany) kn-keyword=ƒhƒCƒc•t‹ß‚ÌtE5ŒŽ‚Ì‹CŒó‚Æ‹Gߊ´ (Climate and seasonal feeling in spring/May around Germany) en-keyword=ESD ‹³Žt‹³ˆç (Teacher education on ESD) kn-keyword=ESD ‹³Žt‹³ˆç (Teacher education on ESD) en-keyword=ˆÙŽ¿‚È‘¼ŽÒ‚Ö‚Ì—‰ð (Understanding of heterogeneous others) kn-keyword=ˆÙŽ¿‚È‘¼ŽÒ‚Ö‚Ì—‰ð (Understanding of heterogeneous others) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=147 end-page=161 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Teacher Response Processes to Behavioral Problems in Students with Mild Intellectual Disabilities: An Examination Based on Practices at High School Division of Special Needs School A kn-title=Œy“x’m“IáŠQ‚Ì‚ ‚鶓k‚Ìs“®–â‘è‚Ö‚Ì‹³ˆõ‘Ήž‰ß’ö@\A ’m“IáŠQ“Á•ÊŽx‰‡ŠwZ‚“™•”‚Å‚ÌŽÀ‘HŒŸ“¢‚ð’Ê‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract=The purpose of this study is to clarify the framework for teachers when addressing behavioral problems of students in the high school division of a special needs school for students with intellectual disabilities. The methodology involved conducting interviews with four experienced teachers from School A, a special needs school for students with intellectual disabilities, which had successfully navigated difficult periods due to challenges in student guidance. Qualitative analysis was conducted using the Modified Grounded Theory Approach (M-GTA). As a result, two core categories emerged: "Building relationships with individuals that foster a sense of security" and "Aiming for shared and unified approaches." Sixteen concepts were generated. When faced with behavioral problems, teachers focused on "Building relationships with individuals that foster a sense of security" as the axis for responding to students, while behind the scenes the teachers worked collectively toward "Aiming for shared and unified approaches." Finally, based on the framework clarified in this study, a hierarchical, comprehensive support system, including individualized support, was proposed. kn-abstract=@–{Œ¤‹†‚Ì–Ú“I‚ÍC’m“IáŠQ“Á•ÊŽx‰‡ŠwZ‚“™•”‚ÉÝЂ·‚鶓k‚Ìs“®–â‘è‚É’…–Ú‚µCŠwZŒ»ê‚Å‹³ˆõ‚ª“K؂ɑΉž‚·‚éۂ̘g‘g‚݂𖾂炩‚É‚·‚邱‚Æ‚Å‚ ‚éB‚»‚Ì•û–@‚Æ‚µ‚ÄC¶“kŽw“±ã‚̉ۑè‚ð——R‚Æ‚·‚鋳ˆç¢“ïŠú‚ðæ‚è‰z‚¦‚½A ’m“IáŠQ“Á•ÊŽx‰‡ŠwZ‚“™•”‚ÉŠ‘®‚µ‚Ä‚¢‚½ŒoŒ±–L•x‚È‹³ˆõ4–¼‚É–ÊÚ’²¸‚ðŽÀŽ{‚µCM-GTA ‚ÌŽè–@‚ð‰‡—p‚µ‚½Ž¿“I•ªÍ‚ðs‚Á‚½B‚»‚ÌŒ‹‰ÊCyˆÀSŠ´‚ð¶‚ތ‚Ƃ̊֌W‚­‚èz‚Æy‘Ήž•û–@‚Ì‹¤—L‚Æ“ˆê‰»‚ð–ÚŽw‚·zŠÖŒW«‚ªƒRƒAEƒJƒeƒSƒŠ[‚ƈʒu‚«C16‚Ì”ŠT”O‚𶬂µ‚½Bs“®–â‘è‚É’¼–Ê‚µ‚½‹³ˆõ‚ÍC¶“k‚ɑ΂µ‚Ä‚ÍyˆÀSŠ´‚ð¶‚ތ‚Ƃ̊֌W‚­‚èz‚ð‘Ήž‚ÌŽ²‚Æ‚µC‚»‚Ì”wŒã‚Å‚ÍŠwZ‚Æ‚µ‚Äy‘Ήž•û–@‚Ì‹¤—L‚Æ“ˆê‰»‚ð–ÚŽw‚·z‚½‚ß‚Ì“®‚«‚ð‚µ‚Ä‚¢‚½BÅŒã‚ÉC–{Œ¤‹†‚Å–¾‚ç‚©‚Æ‚È‚Á‚½‘Ήž‚̘g‘g‚݂ɂ‚¢‚ÄlŽ@‚µ‚½ŠÏ“_‚©‚çCŒÂ•Ê‚ÌŽžŠÔ‚ðŠÜ‚ÞŠK‘w«‚Ì‚ ‚é•ïŠ‡“I‚ÈŽx‰‡ƒVƒXƒeƒ€‚ðˆê‚‚̒ñˆÄ‚Æ‚µ‚½B en-copyright= kn-copyright= en-aut-name=TOKIMITSUHideaki en-aut-sei=TOKIMITSU en-aut-mei=Hideaki kn-aut-name=ŽžŒõG–¾ kn-aut-sei=ŽžŒõ kn-aut-mei=G–¾ aut-affil-num=1 ORCID= en-aut-name=MIYAZAKIYoshio en-aut-sei=MIYAZAKI en-aut-mei=Yoshio kn-aut-name=‹{ú±‘P˜Y kn-aut-sei=‹{ú± kn-aut-mei=‘P˜Y aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Education (Professional Degree Course), Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@¶ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=‚“™•” (High school division) kn-keyword=‚“™•” (High school division) en-keyword=Œy“x’m“IáŠQ (Mild intellectual disabilities) kn-keyword=Œy“x’m“IáŠQ (Mild intellectual disabilities) en-keyword=”­’BáŠQ (Developmental disorders) kn-keyword=”­’BáŠQ (Developmental disorders) en-keyword=s“®–â‘è (Behavioral problems) kn-keyword=s“®–â‘è (Behavioral problems) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=133 end-page=145 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Image of Mushroom Created by Junior High School Science Textbooks: Suggestions for Learning about Mushroom from Diachronic Surveys kn-title=’†ŠwZ—‰È‹³‰È‘‚ª‚‚­‚èã‚°‚Ä‚«‚½‚«‚Ì‚±‘œ@\’ÊŽž“I’²¸‚©‚瓾‚é‚«‚Ì‚±‚ð„‚éŠwK‚Ö‚ÌŽ¦´\ en-subtitle= kn-subtitle= en-abstract=@In this paper, we examined the image of mushroom in postwar junior high school science textbooks from four perspectives: (1) which species of mushroom were covered, (2) whether they were classified as plants or not, (3) what makes up the body of a mushroom, and (4) how they functioned in an ecosystem. The 47 species were identified through a periodic survey. Although a total of 47 species have appeared in science textbooks, we pointed out that in recent years, the focus has shifted to the role of mushroom as decomposers, rather than to species awareness. We also pointed out that although mycorrhizal fungi have been discussed in textbooks, there was no reference to the perspective in a plant-fungal symbiosis, which raises the possibility of developing learning that aims to understand symbiosis/interactions within a nature ecosystem. kn-abstract=@–{e‚Å‚ÍCíŒã’†ŠwZ—‰ÈŒŸ’苳‰È‘‚É‚¨‚¯‚é‚«‚Ì‚±‚̈µ‚í‚ê•ûC‚·‚È‚í‚¿ŠwKŽÒ‚ªŽó‚¯Žæ‚邱‚Æ‚É‚È‚é‚«‚Ì‚±‘œ‚ɂ‚¢‚ÄC‡@‚ǂ̂悤‚È‚«‚Ì‚±‚ªˆµ‚í‚ê‚Ä‚«‚½‚Ì‚©C‡AA•¨‚É•ª—Þ‚³‚ê‚Ä‚¢‚é‚©”Û‚©C‡B‚«‚Ì‚±‚Ì‚©‚炾‚͉½‚ÅŒ`¬‚³‚ê‚Ä‚¢‚é‚Ì‚©C‡C¶‘ÔŒn‚É‚¨‚¯‚é“­‚«‚ÌŽl‚‚̊ϓ_‚©‚çC’ÊŽž“I‚È’²¸‚É‚æ‚Á‚Ä–¾‚ç‚©‚É‚µ‚½B‘S47Ží‚ª‚±‚ê‚Ü‚Å‚Ì—‰È‹³‰È‘‚Å“oꂵ‚Ä‚«‚½‚ªC‹ß”N‚ÍŽí‚ւ̈ӎ¯‚Æ‚¢‚¤‚æ‚è‚àC‚«‚Ì‚±‚ª•ª‰ðŽÒ‚Æ‚µ‚Ä‚Ì–ðŠ„‚ðŽ‚‚±‚Æ‚É‚Ì‚ÝÅ“_‚ª“–‚Ä‚ç‚ê‚Ä‚«‚Ä‚¢‚邱‚Æ‚ðŽw“E‚µ‚½B‚Ü‚½C‚±‚ê‚Ü‚Å‹³‰È‘‚É‚¨‚¢‚Ä‚Í‹Ûª«‚Ì‚«‚Ì‚±Ž©‘̂ɂ‚¢‚ÄŽæ‚èã‚°‚ç‚ê‚‚‚àC‚»‚̶‘ÔŒn‚É‚¨‚¯‚é‘Š—˜‹¤¶‚ÌŠÏ“_‚Ö‚ÌŒ¾‹y‚Í‚È‚¢‚±‚Æ‚©‚çC‘Š—˜‹¤¶‚Ì—‰ð‚ð–ÚŽw‚·ŠwK‚ÌŠJ”­‚ª‰Â”\«‚Æ‚µ‚Ä•‚‚©‚Ñオ‚Á‚Ä‚­‚邱‚Æ‚àŽw“E‚µ‚½B en-copyright= kn-copyright= en-aut-name=TAKAGIRisa en-aut-sei=TAKAGI en-aut-mei=Risa kn-aut-name=ûü–Ø—¢Ê kn-aut-sei=ûü–Ø kn-aut-mei=—¢Ê aut-affil-num=1 ORCID= en-aut-name=IKEDAMasafumi en-aut-sei=IKEDA en-aut-mei=Masafumi kn-aut-name=’r“c‹§Žj kn-aut-sei=’r“c kn-aut-mei=‹§Žj aut-affil-num=2 ORCID= en-aut-name=YAMAMOTOMasaya en-aut-sei=YAMAMOTO en-aut-mei=Masaya kn-aut-name=ŽR–{«–ç kn-aut-sei=ŽR–{ kn-aut-mei=«–ç aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Education (Professional Degree Corse), Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@¶ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=3 en-affil=Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@ŠwZ‹³ˆçŒ¤‹†‰È en-keyword=‹Û—Þ (Fungus) kn-keyword=‹Û—Þ (Fungus) en-keyword=‹Ûª‹Û (Mycorrhizal Fungi) kn-keyword=‹Ûª‹Û (Mycorrhizal Fungi) en-keyword=•…¶‹Û (Saprobic Fungi) kn-keyword=•…¶‹Û (Saprobic Fungi) en-keyword=‘Š—˜‹¤¶ (Symbiosis) kn-keyword=‘Š—˜‹¤¶ (Symbiosis) en-keyword=‹³ÞŽj (History of teaching materials) kn-keyword=‹³ÞŽj (History of teaching materials) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=119 end-page=132 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Development of Thoughts on the Effective Use of School Libraries and Collaboration with Teacher-Librarians and School Librarians in Japanese Language Arts: From a Survey of the Journal Kyoiku Kagaku Kokugo Kyoiku kn-title=ŠwZ}‘ŠÙ‚ÌŠˆ—p‚ÆŽi‘‹³—@EŠwZŽi‘‚Æ‚Ì‹¦“­‚ð‚ß‚®‚鑌ꋳˆçŽv’ª‚Ì“WŠJ@\w‹³ˆç‰ÈŠw‘Œê‹³ˆçxŽ‚Ì’²¸‚©‚ç\ en-subtitle= kn-subtitle= en-abstract=@School libraries are mentioned by government guidelines for teaching, and it is also closely related to Japanese language arts. Previous studies have reported the necessity of collaboration with teacher-librarians and school librarians. However, there has been no study of what kind of collaboration has been conducted in Japanese language arts to date. Therefore, the purpose of this study is to examine how school libraries are utilized in Japanese language arts based on a survey of educational journals, and to organize references to teacher-librarians and school librarians. As a result, we pointed out that while school libraries have been utilized in Japanese language arts in elementary and junior high schools, the collaboration with teacher-librarians and school librarians may not have been focused on, and that the reason for this is the lack of human resources, while some valuable collaborations can be found. kn-abstract=@ŠwZ}‘ŠÙ‚ÍCŠwKŽw“±—v—Ì‚Å‚àG‚ê‚ç‚ê‚Ä‚¨‚èC‘Œê‰È‚Æ‚ÌŠÖ˜A‚à[‚¢B‚Ü‚½æsŒ¤‹†‚Å‚ÍCŽi‘‹³—@‚âŠwZŽi‘‚Æ‚Ì‹¦“­‚Ì•K—v«‚ª‘i‚¦‚ç‚ê‚Ä‚¢‚éB‚µ‚©‚µ‚±‚ê‚Ü‚Å‚Ì‘Œê‹³ˆç‚Å‚ÍC‚ǂ̂悤‚È‹¦“­‚ª‚È‚³‚ê‚Ä‚¢‚½‚Ì‚©‚Æ‚¢‚¤ŒŸ“¢‚ª‚È‚³‚ê‚Ä‚¢‚È‚¢B‚»‚±‚ÅC–{Œ¤‹†‚Å‚ÍC‹³ˆçŽGŽ‚Ì’²¸‚ð‚à‚Æ‚ÉC‘Œê‰È‚É‚¨‚¢‚Ä‚ÍCŠwZ}‘ŠÙ‚ª‚ǂ̂悤‚ÉŠˆ—p‚³‚ê‚Ä‚«‚½‚Ì‚©CŽi‘‹³—@‚âŠwZŽi‘‚Æ‚Ì‹¦“­‚͂ǂ̂悤‚È‘Ô“x‚ª‚Æ‚ç‚ê‚Ä‚«‚½‚Ì‚©‚𖾂炩‚É‚·‚邱‚Æ‚ð–Ú“I‚Æ‚µ‚½B’²¸‚Å‚ÍC}‘ŠÙ‚ÉŒ¾‹y‚µ‚Ä‚¢‚é˜_•¶‚âŠwZ}‘ŠÙ‚ðŠˆ—p‚µ‚½ŽÀ‘HEŽw“±—á‚ð’Šo‚µC•ªÍ‚µ‚½BŽÀ‘HEŽw“±—á‚Ì•ªÍ‚©‚ç‚ÍC¬E’†ŠwZ‚Ì‘Œê‰È‚É‚¨‚¢‚ÄŠwZ}‘ŠÙ‚ÍŠˆ—p‚³‚ê‚Ä‚«‚½ˆê•û‚ÅCŽi‘‹³—@‚âŠwZŽi‘‚Æ‚Ì‹¦“­‚É‚Í’…–Ú‚ª‹y‚ñ‚Å‚¢‚È‚¢ó‹µ‚ª–¾‚ç‚©‚É‚È‚Á‚½B‚Ü‚½CŽi‘‹³—@‚âŠwZŽi‘‚ÉŠÖ‚·‚錾‹y‚©‚ç‚ÍCl“IƒŠƒ\[ƒX‚É‚»‚ÌŒ´ˆö‚ð‹‚ß‚éŽv’ª‚ª‰M‚¦‚½‚à‚Ì‚ÌC‰¿’l‚ ‚鋦“­‚àŒ©Žó‚¯‚ç‚ê‚邱‚Æ‚ðŽw“E‚µ‚½B en-copyright= kn-copyright= en-aut-name=SAISHOYumi en-aut-sei=SAISHO en-aut-mei=Yumi kn-aut-name=Å‘Š—L–¢ kn-aut-sei=Å‘Š kn-aut-mei=—L–¢ aut-affil-num=1 ORCID= en-aut-name=IKEDAMasafumi en-aut-sei=IKEDA en-aut-mei=Masafumi kn-aut-name=’r“c‹§Žj kn-aut-sei=’r“c kn-aut-mei=‹§Žj aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of EducationiProfessional Degree CorsejCOkayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@¶ affil-num=2 en-affil=Faculty of EducationCOkayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=ŽGŽ’²¸ (survey of journals) kn-keyword=ŽGŽ’²¸ (survey of journals) en-keyword=“Ç‘Žw“± (reading instruction) kn-keyword=“Ç‘Žw“± (reading instruction) en-keyword=’T‹†“I‚ÈŠwK (inquiry-based learning) kn-keyword=’T‹†“I‚ÈŠwK (inquiry-based learning) en-keyword=‘Œê‹³ˆçŽj (history of Japanese Language Arts) kn-keyword=‘Œê‹³ˆçŽj (history of Japanese Language Arts) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=107 end-page=118 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of Practical Results of the Liberal Arts Education Class gCreativity in Lifeh at Okayama University ‡V kn-title=‘åŠw‹³—{‹³ˆç‚É‚¨‚¯‚é‘n‘¢«‚ðdŽ‹‚µ‚½’T‹†Œ^Žö‹Æ‚Ì•]‰¿@‰ªŽR‘åŠw‹³—{‹³ˆç‰È–Úu¶Šˆ‚Ì’†‚Ì‘n‘¢«v‚ÌŽÀ‘HŒ‹‰Ê‚Ì•ªÍ‡V en-subtitle= kn-subtitle= en-abstract=@Since 2022, in the liberal arts education course gModernity and Society,h a class entitled gCreativity in Lifeh has been implemented, in which students propose gOkadai Goodsh using gcolorh as the theme. According to the questionnaires conducted before and after the class, the students regarded creativity as gimportant for me,h were ginterested in communicating with others and engaging in creative activities,h and changed their evaluation to a positive one, saying gI am creativeh after the class. This class was found to be highly effective in promoting gawareness of one's own existence to think, feel, and judge independently and interactively. We believe that the main theme and the content of the inquiry activities in this class were suitable for the inquiry-based learning of university students. kn-abstract=@2022”N‚æ‚苳—{‹³ˆç‰È–ÚuŒ»‘ã‚ƎЉïv‚É‚¨‚¢‚ÄCuFv‚ðŽå‘è‚É‚µ‚Äu‰ª‘åƒOƒbƒYv‚Ì’ñˆÄ‚ðs‚¤’T‹†Œ^Žö‹Æu¶Šˆ‚Ì’†‚Ì‘n‘¢«v‚ðŠJu‚µ‚Ä‚¢‚éBŽö‹Æ‘OŒã‚̃Aƒ“ƒP[ƒg‚É‚æ‚é‚ÆCŠw¶‚ÍuŽ©•ª‚É‚Æ‚Á‚Ä‘n‘¢«‚Íd—vv‚Æ‘¨‚¦Cu‘¼ŽÒ‚ƃRƒ~ƒ…ƒjƒP[ƒVƒ‡ƒ“‚ðŽæ‚è‚È‚ª‚ç‘n‘¢“I‚ÈŠˆ“®‚ð‚·‚é‚±‚Æ‚É‹»–¡v‚ª‚ ‚èCŽö‹ÆŒã‚ÍuŽ©•ª‚Ì‚±‚Æ‚ð‘n‘¢“I‚Å‚ ‚év‚Æm’è“I‚È•]‰¿‚Æ‚È‚Á‚Ä‚¢‚½B‚±‚ÌŽö‹Æ‚ÍuŽå‘Ì“IC‘Θb“I‚Él‚¦CŠ´‚¶C”»’f‚·‚鎩•ªŽ©g‚Ì‘¶Ý‚ðˆÓŽ¯‚·‚邱‚Æv‚𑣂·Œø‰Ê‚ª‘å‚«‚¢‚±‚Æ‚ª•ª‚©‚Á‚½B‚±‚Ì‚R”NŠÔ‚ÌŽÀ‘H‚ÍCŽåŽ²‚Æ‚È‚éƒe[ƒ}‚Æ’T‹†Šˆ“®‚Ì“à—e‚ª‘åŠw¶‚Ì’T‹†“I‚ÈŠw‚Ñ‚É“K‚µ‚½‚à‚Ì‚Å‚ ‚Á‚½‚Æl‚¦‚Ä‚¢‚éB en-copyright= kn-copyright= en-aut-name=SHINOHARAYoko en-aut-sei=SHINOHARA en-aut-mei=Yoko kn-aut-name=ŽÂŒ´—zŽq kn-aut-sei=ŽÂŒ´ kn-aut-mei=—zŽq aut-affil-num=1 ORCID= en-aut-name=INADAYoshihiko en-aut-sei=INADA en-aut-mei=Yoshihiko kn-aut-name=ˆî“c‰À•F kn-aut-sei=ˆî“c kn-aut-mei=‰À•F aut-affil-num=2 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=’T‹†Œ^Žö‹Æ kn-keyword=’T‹†Œ^Žö‹Æ en-keyword=‘n‘¢« (Creativity) kn-keyword=‘n‘¢« (Creativity) en-keyword=•¨—Šw (Physics) kn-keyword=•¨—Šw (Physics) en-keyword=”í•žŠw (Clothing) kn-keyword=”í•žŠw (Clothing) en-keyword=‰ª‘åƒOƒbƒY (Okadai-Goods) kn-keyword=‰ª‘åƒOƒbƒY (Okadai-Goods) en-keyword=ICT Šˆ—p (ICT) kn-keyword=ICT Šˆ—p (ICT) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=91 end-page=105 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Reflections of Early Care and Education Practitioners, as Indicated in the Content on the Care and Education of Kindergarten Children Published by Japanfs Ministry of Education, Culture, Sports, Science and Technology kn-title=—c’t‰€‚Ì•Ûˆç‘S‘Ì‚ÉŠÖ‚·‚镶•”‰ÈŠwÈŒö•\Ž‘—¿‚ÉŽ¦‚³‚ê‚Ä‚¢‚é•ÛˆçŽÒ‚ÌU‚è•Ô‚è‚ÌŽd•û‚ÌŒŸ“¢ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–{Œ¤‹†‚Å‚ÍC‚Ü‚¸C‰ä‚ª‘‚Ì•ÛˆçŽ{Ý‚É‚¨‚¯‚éƒJƒŠƒLƒ…ƒ‰ƒ€Eƒ}ƒlƒWƒƒ“ƒg‚ÉŠÖ‚·‚éæsŒ¤‹†‚ðŠTŠÏ‚µCƒJƒŠƒLƒ…ƒ‰ƒ€Eƒ}ƒlƒWƒƒ“ƒg‚ðŽÀŒ»‚·‚邽‚ß‚É•K—v‚ÈC•Ûˆç‚Ì–Ú•WE‚Ë‚ç‚¢E“à—e‚̘AŠÖ«‚ÌŠm•Û‚³‚ꂽ‘S‘Ì“IŒv‰æ‚Ì쬂ª¢“ï‚È󋵂ɂ ‚邱‚Æ‚ðŠm”F‚µ‚½B‘±‚¢‚ÄC•Ûˆç‚Ì–Ú•WE‚Ë‚ç‚¢E“à—e‚̘AŠÖ«‚ðŠm•Û‚·‚éã‚ÅC‚»‚Ì‚±‚Æ‚ð‰Â”\‚É‚·‚é•ÛˆçŽÒ‚ÌU‚è•Ô‚è‚ÌŽd•û‚ª•s‰ÂŒ‡‚ƂȂ邱‚Ƃ𓥂܂¦‚ÄC—c’t‰€‚Ì•Ûˆç‘S‘Ì‚ÉŠÖ‚·‚镶•”‰ÈŠwÈŒö•\Ž‘—¿‚ÉŽ¦‚³‚ê‚Ä‚¢‚éC•ÛˆçŽÒ‚ÌU‚è•Ô‚è‚Ì–Ú“ICŠÏ“_C•û–@‚ð’Šo‚µ®—‚µCŒŸ“¢‚µ‚½B‚»‚ÌŒ‹‰ÊC•ÛˆçŽÒ‚Ì’·Šú‚ÌU‚è•Ô‚è‚ÉŠÖ‚µ‚ÄŽ¦‚³‚ê‚Ä‚¢‚é‹Lq‚Å‚ÍC‹ï‘Ì«‚ª–R‚µ‚­C•Ûˆç‚Ì–Ú•WE‚Ë‚ç‚¢E“à—e‚̘AŠÖ«‚ÌŠm•Û‚³‚ꂽ’·ŠúŽw“±Œv‰æ‹y‚Ñ‘S‘Ì“IŒv‰æ‚ð쬂·‚éã‚ÅCŽÀ—p“I‚Å‚Í‚È‚¢‚±‚Ƃ𖾂炩‚É‚µ‚½B en-copyright= kn-copyright= en-aut-name=ARITASho en-aut-sei=ARITA en-aut-mei=Sho kn-aut-name=—L“cãÄ kn-aut-sei=—L“c kn-aut-mei=ãÄ aut-affil-num=1 ORCID= en-aut-name=YOKOMATSUTomoyoshi en-aut-sei=YOKOMATSU en-aut-mei=Tomoyoshi kn-aut-name=‰¡¼—F‹` kn-aut-sei=‰¡¼ kn-aut-mei=—F‹` aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Education, Okayama University (Masterfs Course) kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@¶ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=•ÛˆçŽÒ‚ÌU‚è•Ô‚è (reflections of early care and education practitioners) kn-keyword=•ÛˆçŽÒ‚ÌU‚è•Ô‚è (reflections of early care and education practitioners) en-keyword=—c’t‰€ (kindergarten) kn-keyword=—c’t‰€ (kindergarten) en-keyword=ƒJƒŠƒLƒ…ƒ‰ƒ€Eƒ}ƒlƒWƒƒ“ƒg (curriculum management) kn-keyword=ƒJƒŠƒLƒ…ƒ‰ƒ€Eƒ}ƒlƒWƒƒ“ƒg (curriculum management) en-keyword=•¶•”‰ÈŠwÈŒö•\Ž‘—¿ (the content on the care and education of kindergarten children published by Japanfs Ministry of Education, Culture, Sports, Science and Technology) kn-keyword=•¶•”‰ÈŠwÈŒö•\Ž‘—¿ (the content on the care and education of kindergarten children published by Japanfs Ministry of Education, Culture, Sports, Science and Technology) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=75 end-page=89 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Trends in Awareness of Earthquake Disaster Prevention among Students Aspiring to Become Childcare Providers kn-title=•ÛˆçŽÒŽu–]Šw¶‚Ì’nk–hЂɑ΂·‚éˆÓŽ¯‚ÌŒXŒü en-subtitle= kn-subtitle= en-abstract=@In recent years, under the growing sense of crisis about the possibility of a major earthquake in the Nankai Trough, etc., it has become necessary to have more awareness of earthquake disaster prevention and to take measures for disaster prevention regularly. The purpose of this study was to clarify the actual situation of students who aspire to become childcare providers to protect children's lives. As a result of a questionnaire survey, we found that their awareness of the danger of earthquakes tended to differ by grade level and that their understanding and knowledge of earthquake disaster prevention differed depending on their awareness of earthquake disaster prevention. In the future, it will be necessary to consider conducting evacuation drills in kindergartens or nursery schools and providing guidance on disaster prevention education in training programs for childcare providers. kn-abstract=@‹ß”NC“ìŠCƒgƒ‰ƒt‹‘å’nk‚â“sŽs’¼‰ºŒ^’nk‚ɑ΂·‚éŠë‹@Š´‚ª‚‚Ü‚é’†C’nk–hЂɑ΂·‚é‚‚¢ˆÓŽ¯‚ðŽ‚¿C•’i‚©‚ç–hЂɊւ·‚éŽæ‚è‘g‚Ý‚É“w‚߂邱‚Æ‚ª‹‚ß‚ç‚ê‚Ä‚¢‚éB–{Œ¤‹†‚Å‚ÍCŽq‚Ç‚à‚Ì–½‚ðŽç‚é•ÛˆçŽÒ‚ð–ÚŽw‚·Žu–]Šw¶‚ªC’nkЊQ‚ɑ΂·‚éˆÓŽ¯‚ð‚ǂ̂悤‚ÉŽ‚¿C’nk–hЂɊւ·‚é’mŽ¯‚â—‰ð‚ð‚Ç‚Ì’ö“x•ÛŽ‚µ‚Ä‚¢‚é‚Ì‚©‚ɂ‚¢‚ÄC‚»‚ÌŽÀ‘Ԃ𖾂炩‚É‚·‚邱‚Æ‚ð–Ú“I‚Æ‚µ‚½B•ÛˆçŽÒ—{¬Z‚S‘åŠw‚ÌŠw¶‚ɑ΂·‚鎿–⎆’²¸‚ðs‚Á‚½Œ‹‰ÊC’nk‚Ö‚ÌŠë‹@ˆÓŽ¯‚ªŠw”N‚É‚æ‚Á‚ĈقȂéŒXŒü‚É‚ ‚邱‚Æ‚âC’nk–hЂɊւ·‚éˆÓŽ¯‚Ì‚’á‚É‚æ‚Á‚ÄC’nk‚ɑ΂·‚é’mŽ¯‚â”FŽ¯‚̈Ⴂ‚ª‚ ‚邱‚Æ‚ª”»–¾‚µ‚½B¡ŒãC—cŽ™‹³ˆçE•ÛˆçŽ{Ý‚É‚¨‚¯‚é”ð“ïŒP—û‚ÌŽÀŽ{‚âC•ÛˆçŽÒ—{¬‰Û’ö‚É‚¨‚¢‚Ä–hЋ³ˆç‚ÉŠÖ‚·‚éŽw“±‚ðŒŸ“¢‚µ‚Ä‚¢‚­‚±‚Æ‚ª‹‚ß‚ç‚ê‚éB en-copyright= kn-copyright= en-aut-name=SATOHDaisuke en-aut-sei=SATOH en-aut-mei=Daisuke kn-aut-name=²“¡‘å‰î kn-aut-sei=²“¡ kn-aut-mei=‘å‰î aut-affil-num=1 ORCID= en-aut-name=TAKAHASHIKei en-aut-sei=TAKAHASHI en-aut-mei=Kei kn-aut-name=ûü‹´Œd kn-aut-sei=ûü‹´ kn-aut-mei=Œd aut-affil-num=2 ORCID= en-aut-name=BABANoriko en-aut-sei=BABA en-aut-mei=Noriko kn-aut-name=”nêŒPŽq kn-aut-sei=”nê kn-aut-mei=ŒPŽq aut-affil-num=3 ORCID= affil-num=1 en-affil=Faculty of Health and Welfare, Kawasaki University of Medical Welfare kn-affil=ìèˆã—ÕŸŽƒ‘åŠwˆã—ÕŸŽƒŠw•” affil-num=2 en-affil=Faculty of Childhood Education, Kurashiki Sakuyo University kn-affil=‚­‚炵‚«ì—z‘åŠwŽq‚Ç‚à‹³ˆçŠw•” affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=’nk–hÐ (earthquake disaster prevention) kn-keyword=’nk–hÐ (earthquake disaster prevention) en-keyword=•ÛˆçŽÒŽu–]Šw¶ (students aspiring to become childcare providers) kn-keyword=•ÛˆçŽÒŽu–]Šw¶ (students aspiring to become childcare providers) en-keyword=ˆÓŽ¯’²¸ (questionnaire survey) kn-keyword=ˆÓŽ¯’²¸ (questionnaire survey) en-keyword=Šë‹@ˆÓŽ¯ (sense of crisis) kn-keyword=Šë‹@ˆÓŽ¯ (sense of crisis) en-keyword=’nk–hЋ³ˆç (education for earthquake disaster prevention) kn-keyword=’nk–hЋ³ˆç (education for earthquake disaster prevention) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=59 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Career Years on the Coordination Behavior of Yogo Teachers kn-title=—{Œì‹³—@‚̃R[ƒfƒBƒl[ƒVƒ‡ƒ“s“®‚É‹y‚Ú‚·ƒLƒƒƒŠƒA”N”‚̉e‹¿ en-subtitle= kn-subtitle= en-abstract=The purpose of this study was to clarify the factors influencing coordination behavior of Yogo teachers and the relationship between the occurrence process of the factors and career years. The subjects analyzed were 695 persons working in public elementary and junior high schools. The effect of years of career was seen in the improvement of scale scores of factors related to the stages of coordination behavior and motivation, as well as subscale scores of the factors.
The relationship between the number of years of career and factors related to the generation process of coordination behavior suggested three characteristics. That is, (1) The establishment of a foundation for organizational support that starts from collaboration, due to the correlation between factors showing high subscale scores unaffected by the number of years of career, and (2) The correlation among factors of motivational factors whose subscale scores increase with the number of years of career, which leads to the promotion of individualized support efforts, and (3) Correlation between factors of leader recognition and individual support seen in the career category of 11 years or more, and which leads to the promotion of expansion to management of organizational support. kn-abstract=@–{Œ¤‹†‚Ì–Ú“I‚ÍC—{Œì‹³—@‚̃R[ƒfƒBƒl[ƒVƒ‡ƒ“s“®‚ɉe‹¿‚·‚é—vˆö‚â‚»‚̈öŽq‚ÌŒXŒü‚ðƒLƒƒƒŠƒA”N”‚©‚瑨‚¦C‚±‚ê‚ç‚ƃR[ƒfƒBƒl[ƒVƒ‡ƒ“s“®‚̶‹NƒvƒƒZƒX‚Æ‚ÌŠÖŒW‚ɂ‚¢‚Ä–¾‚ç‚©‚É‚·‚邱‚Æ‚Å‚ ‚Á‚½B•ªÍ‘ÎÛ‚ÍCŒö—§¬ŠwZE’†ŠwZ‹Î–±695–¼‚Æ‚µ‚½BƒLƒƒƒŠƒA”N”‚̉e‹¿‚ÍCƒR[ƒfƒBƒl[ƒVƒ‡ƒ“s“®‚Æ“®‹@‚¯‚Ì’iŠK‚ÉŠÖ‚í‚é—vˆö‚ÌŽÚ“x“¾“_‚âCˆöŽq‚̉ºˆÊŽÚ“x“¾“_‚ÌŒüã‚ÉŒ©‚ç‚ꂽB‚Ü‚½CƒLƒƒƒŠƒA”N”‚ƃR[ƒfƒBƒl[ƒVƒ‡ƒ“s“®‚̶‹NƒvƒƒZƒX‚ÉŠÖ‚í‚éˆöŽqŠÔ‚ÌŠÖŒW‚©‚ç‚ÍCi1jƒLƒƒƒŠƒA”N”‚ɉe‹¿‚³‚ê‚È‚¢‚‚¢‰ºˆÊŽÚ“x“¾“_‚ðŽ¦‚·ˆöŽqŠÔ‘ŠŠÖ‚É‚æ‚éC‹¦“­‚ð‹N“_‚É‚µ‚½‘gDŽx‰‡‚ÌŠî”Ղ­‚èCi2jƒLƒƒƒŠƒA”N”‚É‚æ‚艺ˆÊŽÚ“x“¾“_‚ª‚‚Ü‚é“®‹@‚¯—vˆö‚̈öŽqŠÔ‘ŠŠÖ‚É‚æ‚éCŒÂ•ÊŽx‰‡‚ÌŽæ‘g„i‚ւ̂‚Ȃª‚èCi3j11”NˆÈãƒLƒƒƒŠƒA‹æ•ª‚ÅŒ©‚ç‚ê‚郊[ƒ_[”F’m‚ƌ•ʎx‰‡‚̈öŽqŠÔ‘ŠŠÖC‹y‚Ñ‘gD“IŽx‰‡‚̃}ƒlƒWƒƒ“ƒg‚Ö‚ÌL‚ª‚èC‚Ì‚R‚‚̓Á’¥‚ð‚à‚‚±‚Æ‚ªŽ¦´‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=SUZUKIKaoru en-aut-sei=SUZUKI en-aut-mei=Kaoru kn-aut-name=—é–ØŒO kn-aut-sei=—é–Ø kn-aut-mei=ŒO aut-affil-num=1 ORCID= en-aut-name=MIMURAYukari en-aut-sei=MIMURA en-aut-mei=Yukari kn-aut-name=ŽO‘º—R—¢ kn-aut-sei=ŽO‘º kn-aut-mei=—R—¢ aut-affil-num=2 ORCID= affil-num=1 en-affil=Research student, United Graduate School of Education, Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw˜A‡‘åŠw‰@‹³ˆçŠwŒ¤‹†‰ÈŒ¤‹†¶ affil-num=2 en-affil=Graduate School of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=—{Œì‹³—@ (Yogo teacher) kn-keyword=—{Œì‹³—@ (Yogo teacher) en-keyword=ƒR[ƒfƒBƒl[ƒVƒ‡ƒ“s“® (coordination behavior) kn-keyword=ƒR[ƒfƒBƒl[ƒVƒ‡ƒ“s“® (coordination behavior) en-keyword=ŽÚ“x“¾“_ (scale score) kn-keyword=ŽÚ“x“¾“_ (scale score) en-keyword=‰ºˆÊŽÚ“x“¾“_ (subscale score‚’) kn-keyword=‰ºˆÊŽÚ“x“¾“_ (subscale score‚’) en-keyword=s“®‚̶‹NƒvƒƒZƒX (process of behavioral development) kn-keyword=s“®‚̶‹NƒvƒƒZƒX (process of behavioral development) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=33 end-page=44 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Systematic Improvement of Lessons in Elementary Schools ?A Case Study of Japanese Language Instruction Aimed at Realizing the gIdeal Child Imageh? kn-title=¬ŠwZ‚É‚¨‚¯‚é‘gD“I‚ÈŽö‹Æ‰ü‘P‚Ì‚ ‚è•û@?u–ÚŽw‚·Žq‚Ç‚à‘œvŽÀŒ»‚ÉŒü‚¯‚½‘Œê‰ÈŽw“±‚ðŽ–—á‚Æ‚µ‚Ä? en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–{Œ¤‹†‚Ì–Ú“I‚ÍAu–ÚŽw‚·Žq‚Ç‚à‘œvŽÀŒ»‚ÉŒü‚¯‚½‘Œê‰È‚ÌŽö‹Æ‚­‚è‚Ì‹ï‘Ì‚ðŒŸ“¢‚µA¬ŠwZ‚É‚¨‚¯‚é‘gD“I‚ÈŽö‹Æ‰ü‘P‚Ì‚ ‚è•û‚ð’ñŒ¾‚·‚邱‚Æ‚É‚ ‚éB‹ï‘Ì“I‚É‚ÍAu–ÚŽw‚·Žq‚Ç‚à‘œvŽÀŒ»‚ÉŒü‚¯‚½‘Œê‰È‚ÌŽö‹Æ‚­‚è‚ð’Ê‚µ‚ÄA¡‚̎Љ¬ŠwZ‹³ˆç‚É‹‚ß‚é“ÁF‚ ‚éŽö‹Æ‚­‚è‚Ìi‚ß•û‚𖾂炩‚É‚·‚邽‚ßA‹Î–±Z‚Å‚ ‚é‘“‡’¬—§‘“‡¬ŠwZ‚ÉŠ‘®‚·‚鋳Žt‚ÌŽö‹Æ‚­‚è‚ð‘ÎÛ‚ÉŽ–—ጤ‹†‚ð“WŠJ‚µ‚½BŒŸ“¢‚ð’Ê‚¶‚Ä–¾‚ç‚©‚É‚È‚Á‚½‚±‚Æ‚ÍAŽö‹Æ‚­‚è‚É‚¨‚¯‚鋳Žt‚ÌŽvlEŽÀ‘H‰ß’ö‚ÆA‚±‚ê‚ç‚ðŽÀ‘HŽÒ‚ª”½È“I‚É‘¨‚¦’¼‚·‚½‚ß‚Ìu–ÚŽw‚·Žq‚Ç‚à‘œv‚É‚æ‚錾ŒêŠˆ“®‹ï‘̉»‚ÌŽè—§‚Ä‚Å‚ ‚éB‚³‚ç‚ÉAŽö‹Æ‚­‚è‚Ì‘gDEŒn“«‚ÍA‘¼Šw”N‹³Žt‚Ì–ðŠ„‚É‚æ‚Á‚Ä‚à‚½‚炳‚ê‚邱‚Æ‚ªŠm”F‚³‚ꂽ‚±‚Æ‚©‚çA‚»‚ê‚ç‚𓥂܂¦‚‚ÂAu–ÚŽw‚·Žq‚Ç‚à‘œvŽÀŒ»‚ÉŒü‚¯‚½Žö‹Æ‚­‚è‚Ì‚ ‚è•û‚ð‘ÌŒn‰»‚µ‚½B‚»‚¤‚·‚邱‚Æ‚ÅA¬ŠwZ‚É‚¨‚¯‚é‘gD“I‚ÈŽö‹Æ‰ü‘P‚ði‚ß‚Ä‚¢‚­‚½‚߂̉”\«‚ªŒ©o‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=KOMOTOAkihiro en-aut-sei=KOMOTO en-aut-mei=Akihiro kn-aut-name=‰Í–{ÍG kn-aut-sei=‰Í–{ kn-aut-mei=ÍG aut-affil-num=1 ORCID= en-aut-name=MIYAMOTOKoji en-aut-sei=MIYAMOTO en-aut-mei=Koji kn-aut-name=‹{–{_Ž¡ kn-aut-sei=‹{–{ kn-aut-mei=_Ž¡ aut-affil-num=2 ORCID= en-aut-name=IKEDAMasafumi en-aut-sei=IKEDA en-aut-mei=Masafumi kn-aut-name=’r“c‹§Žj kn-aut-sei=’r“c kn-aut-mei=‹§Žj aut-affil-num=3 ORCID= en-aut-name=MATUDASatoshi en-aut-sei=MATUDA en-aut-mei=Satoshi kn-aut-name=¼“c‘ kn-aut-sei=¼“c kn-aut-mei=‘ aut-affil-num=4 ORCID= affil-num=1 en-affil=Hayashima Elementary School (Graduate School of Education (Professional Degree Corse), Okayama University) kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@¶ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=4 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=–ÚŽw‚·Žq‚Ç‚à‘œ (The school's educational goals) kn-keyword=–ÚŽw‚·Žq‚Ç‚à‘œ (The school's educational goals) en-keyword=‰¿’l–Ú•W (into value-objectives) kn-keyword=‰¿’l–Ú•W (into value-objectives) en-keyword=‘ŒêŠw—Í (Japanese language ability) kn-keyword=‘ŒêŠw—Í (Japanese language ability) en-keyword=ƒJƒŠƒLƒ…ƒ‰ƒ€ƒ}ƒlƒWƒƒ“ƒg (Curriculum Management) kn-keyword=ƒJƒŠƒLƒ…ƒ‰ƒ€ƒ}ƒlƒWƒƒ“ƒg (Curriculum Management) en-keyword=‘gDEŒn“« (Organization and Systematic) kn-keyword=‘gDEŒn“« (Organization and Systematic) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=17 end-page=31 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Research of the Image of Teacher-Training Courses among Student Teachers in Non-Faculty of Education kn-title=‘SŠw‹³E‰Û’ö—šCŠw¶‚Ì‹³E‰Û’öƒCƒ[ƒW‚ÉŠÖ‚·‚錤‹† en-subtitle= kn-subtitle= en-abstract=The purpose of this study was to explore the image of teacher-training courses among student teachers in non-faculty of education. In this study, special attention to was paid to the difference first-year students and fourth-year students. This study 1 included student teachers in non-faculty of education. They were asked to answer metaphor-making task : gteacher-training coursesh. Major findings (study 1) were as follows: (a) analysis of metaphors and reasons regarding the image of teacher-training course revealed 19 categories. (b) The category with the most number of descriptions was gA place to learn to become a teacherh followed by gA place to grow as a personh. (c) There were differences in the number of descriptions in some categories between first-year students and fourth-year students. Next, major findings (study 2) were as follows: (a) Exploratory factor analysis of the concept of image of teacher-training courses revealed 11 factors such as gplace for active learningh and ghardh. (b) First-year students and fourth-year students had different scores on three factors: gOpportunity to reflect on the educational experienceh, gGreat valueh and gA place for longterm leaningh. These studies indicated that student teachers in non-faculty of education had various images teacher-training courses, and that there were differences in some images teacher-training course between first-year students and fourth-year students. kn-abstract=@–{Œ¤‹†‚Ì–Ú“I‚ÍC‘SŠw‹³E‰Û’ö—šCŠw¶‚Ì‹³E‰Û’öƒCƒ[ƒW‚ðŒŸ“¢‚·‚邱‚Æ‚Å‚ ‚Á‚½BŒ¤‹†‚P‚ł̓ƒ^ƒtƒ@[–@‚ð—p‚¢‚Ä‘SŠw‹³E‰Û’ö—šCŠw¶‚ð‘ÎÛ‚É‹³E‰Û’öƒCƒ[ƒW‚𒲸‚µC19‚̃JƒeƒSƒŠ[‚ª“¾‚ç‚ꂽBÅ‚à‹Lq‚ª‘½‚¢ƒJƒeƒSƒŠ[‚Íu‹³Žt‚ɂȂ邽‚ß‚ÌŠw‚Ñ‚Ìêv‚Å‚ ‚èCŽŸ‚¢‚Åul‚Æ‚µ‚Ă̬’·‚Ìêv‚Å‚ ‚Á‚½B‚Ü‚½C1”N¶‚Æ4”N¶‚Å‚¢‚­‚‚©‚̃JƒeƒSƒŠ[‚Å—LˆÓ·‚ªŒ©‚ç‚ꂽBŒ¤‹†‚Q‚Å‚ÍCŒ¤‹†‚P‚ðŠî‚É‹³E‰Û’öƒCƒ[ƒW‚𑪒肷‚éŽÚ“xì¬‚ðŽŽ‚Ý‚é‚Æ‹¤‚ÉC1”N¶‚Æ4”N¶‚Å‚Ì”äŠr‚ðs‚Á‚½B’²¸‚ÌŒ‹‰ÊC‹³E‰Û’öƒCƒ[ƒW‚Íu”\“®“I‚ÈŠw‚Ñ‚Ìêvu‘å•Ï‚³v‚È‚Ç‘S11ˆöŽq‚©‚ç‚Ȃ邱‚ÆCu”틳ˆç‘ÌŒ±‚ÌU‚è•Ô‚è‚Ì‹@‰ïvu‚¨“¾Š´vu’·Šú“I‚ÈŠw‚Ñ‚Ìêv‚É‚¨‚¢‚Ä1”N¶‚Æ4”N¶‚Å—LˆÓ·‚ª‚ ‚邱‚ÆC‚ªŽ¦´‚³‚ꂽB–{Œ¤‹†‚©‚ç‘SŠw‹³E‰Û’ö—šCŠw¶‚Ì‹³E‰Û’öƒCƒ[ƒW‚̈ê’[‚ª–¾‚ç‚©‚É‚³‚ê‚é‚Æ‹¤‚ÉC1”N¶‚Æ4”N¶‚Å—L‚µ‚Ä‚¢‚éƒCƒ[ƒW‚ª•”•ª“I‚ɈقȂé‰Â”\«‚ªŽ¦´‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=MISHIMATomotaka en-aut-sei=MISHIMA en-aut-mei=Tomotaka kn-aut-name=ŽO“‡’m„ kn-aut-sei=ŽO“‡ kn-aut-mei=’m„ aut-affil-num=1 ORCID= affil-num=1 en-affil=Center for Teacher Education and Development, Okayama University kn-affil=‰ªŽR‘åŠw‹³Žt‹³ˆçŠJ”­ƒZƒ“ƒ^[ en-keyword=‘SŠw‹³E‰Û’ö—šCŠw¶ (student teachers in non-faculty of education) kn-keyword=‘SŠw‹³E‰Û’ö—šCŠw¶ (student teachers in non-faculty of education) en-keyword=‹³E‰Û’öƒCƒ[ƒW (image of teacher-training courses) kn-keyword=‹³E‰Û’öƒCƒ[ƒW (image of teacher-training courses) en-keyword=ƒƒ^ƒtƒ@[ (metaphor) kn-keyword=ƒƒ^ƒtƒ@[ (metaphor) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=1 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Treatment of Learning about Marriage in High School Home Economics (2): Description Analysis of the Textbooks kn-title=‚“™ŠwZ‰Æ’ë‰È‚É‚¨‚¯‚錋¥‚ÉŠÖ‚·‚éŠwK‚̈µ‚¢i2j@‹³‰È‘‚Ì‹Lq•ªÍ‚ÉŠî‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–{e‚Å‚ÍCu‘½—l‰»‚·‚錋¥v‚Æ‚¢‚¤“ú–{‚ÌŒ»ó‚𓥂܂¦CŒ‹¥‚ÉŠÖ˜A‚·‚éŠwK“à—e‚ªC‚“™ŠwZ‰Æ’ë‰È‚É‚¨‚¢‚Ăǂ̂悤‚Ɉµ‚í‚ê‚Ä‚¢‚é‚©‚ð•ªÍ‚·‚邱‚Æ‚ð–Ú“I‚Æ‚µC•½¬30”N”Å‚Ìw‚“™ŠwZŠwKŽw“±—v—Ìx‚ÉŠî‚¢‚Ä\¬‚³‚ꂽu‰Æ’ëŠî‘bv‚Ì‹³‰È‘10û‚ð—p‚¢‚ÄŒ‹¥‚ÉŠÖ˜A‚·‚éŠwK“à—e‚ð•ªÍ‚µ‚½B•ªÍ‚ÌŒ‹‰ÊC‹³‰È‘‚É‚ÍCwŽw“±—v—Ìx‚ÉŠî‚¢‚ÄŒ‹¥“™‚ÉŠÖ˜A‚·‚é–@§“x‚Ì‹Lq‚ª‚Ý‚ç‚ê‚邱‚ÆCŒ‹¥‚ð‚ß‚®‚錻ó‚â•Ï‰»‚𔽉f‚µ‚½ŠwK“à—e‚ªŽæ‚舵‚í‚ê‚Ä‚¢‚邱‚Æ‚ðŠm”F‚µ‚½B‚Ü‚½C•v•w‚ÌŽC“¯«¥‚ðŽæ‚èã‚°C‹ï‘Ì“I‚ÈŠwKŠˆ“®‚ɂ‚¢‚Ä•ªÍ‚µ‚½Œ‹‰ÊC‹³‰È‘‚É‚æ‚Á‚Ä‚ÍC’mŽ¯‚⌻ó‚ð’ñŽ¦‚·‚éŠwK‚¾‚¯‚Å‚È‚­CŠwKŽÒ‚Å‚ ‚é‚Z¶‚ªŽ©‚çl‚¦‚邱‚ÆC‘I‘ð‚·‚é‚±‚ÆC‚³‚ç‚É‘¼l‚Ì‘I‘ð‚ɂ‚¢‚Ä‚à‹qŠÏ“I‚Él‚¦‚ç‚ê‚é‚悤‚É–â‚¢‚©‚¯‚Ä‚¢‚鋳‰È‘‚à‚Ý‚ç‚ꂽBŒ‹¥‚ÉŠÖ˜A‚·‚é–@—¥CŒê‹å‚ÌŒfÚ‚Ì—L–³CŠwKŠˆ“®‚É‚¨‚¢‚ÄC‹³‰È‘‚É‚æ‚Á‚Ď戵‚¢‚Ì·‚ª‚ ‚邱‚Æ‚ª–¾‚ç‚©‚É‚È‚Á‚½B en-copyright= kn-copyright= en-aut-name=TANABEShiho en-aut-sei=TANABE en-aut-mei=Shiho kn-aut-name=“c糎•à kn-aut-sei=“cç³ kn-aut-mei=Ž•à aut-affil-num=1 ORCID= en-aut-name=LEEKyoungwon en-aut-sei=LEE en-aut-mei=Kyoungwon kn-aut-name=—›ûm•Q kn-aut-sei=—› kn-aut-mei=ûm•Q aut-affil-num=2 ORCID= affil-num=1 en-affil=Fukuyama University kn-affil=•ŸŽR‘åŠw affil-num=2 en-affil=Faculty of EducationCOkayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=‚“™ŠwZ‰Æ’ë‰È (High School Home Economics) kn-keyword=‚“™ŠwZ‰Æ’ë‰È (High School Home Economics) en-keyword=‹³‰È‘ (Textbooks) kn-keyword=‹³‰È‘ (Textbooks) en-keyword=Œ‹¥ (Marriage) kn-keyword=Œ‹¥ (Marriage) en-keyword=‘½—l‰»‚·‚錋¥ kn-keyword=‘½—l‰»‚·‚錋¥ en-keyword=Course of Study kn-keyword=Course of Study END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž†E–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰ªŽR‘åŠw‹³Žt‹³ˆçŠJ”­ƒZƒ“ƒ^[‹I—v ‘æ15† ‘S•¶iˆêŠ‡ƒ_ƒEƒ“ƒ[ƒh—pj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue=1 article-no= start-page=2480231 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Specific enhancement of the translation of thermospermine-responsive uORF-containing mRNAs by ribosomal mutations in Arabidopsis thaliana en-subtitle= kn-subtitle= en-abstract= kn-abstract=Auxin-induced xylem formation in angiosperms is negatively regulated by thermospermine, whose biosynthesis is also induced by auxin. In Arabidopsis thaliana, loss-of-function mutants of ACL5, which encodes thermospermine synthase, exhibit a dwarf phenotype accompanied by excessive xylem formation. Studies of suppressor mutants that recover from the acl5 dwarf phenotype suggest that thermospermine alleviates the inhibitory effect of an upstream open-reading frame (uORF) on the main ORF translation of SAC51 mRNA. Many suppressor mutations for acl5 have been mapped to the uORF conserved in the SAC51 family or to ribosomal protein genes, such as RPL10A, RPL4A, and RACK1A. In this study, we identified newly isolated acl5 suppressors, sac501, sac504, and sac506, which are additional alleles of RPL10A and the uORFs of SAC51 family members, SACL1 and SACL3, respectively. To investigate whether acl5-suppressor alleles of ribosomal genes broadly affect translation of uORF-containing mRNAs, we examined GUS activity in several 5'-GUS fusion constructs. Our results showed that these alleles enhanced GUS activity in SAC51 and SACL3 5'-fusion constructs but had no effect on other 5'-fusion constructs unrelated to thermospermine response. This suggests that these ribosomal proteins are specifically involved in the thermospermine-mediated regulation of mRNA translation. en-copyright= kn-copyright= en-aut-name=MutsudaKoki en-aut-sei=Mutsuda en-aut-mei=Koki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishiiYuichi en-aut-sei=Nishii en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ToyoshimaTomohiko en-aut-sei=Toyoshima en-aut-mei=Tomohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FukushimaHiroko en-aut-sei=Fukushima en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MotoseHiroyasu en-aut-sei=Motose en-aut-mei=Hiroyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakahashiTaku en-aut-sei=Takahashi en-aut-mei=Taku kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=mRNA translation kn-keyword=mRNA translation en-keyword=RPL10 kn-keyword=RPL10 en-keyword=suppressor mutant kn-keyword=suppressor mutant en-keyword=thermospermine kn-keyword=thermospermine en-keyword=uORF kn-keyword=uORF END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Droplet Impact Behavior on Convex Surfaces with a Circumferential Wettability Difference en-subtitle= kn-subtitle= en-abstract= kn-abstract=Controlling the bouncing behavior of the impacting droplets is an important issue for splay cooling, icing prevention, and other applications. The bouncing behavior of impacting droplets on superhydrophobic curved surfaces and flat substrates with a wettability difference has been widely investigated, and droplets impacting these surfaces show shorter contact times than those on superhydrophobic flat surfaces and droplet transport. However, there have been few studies on the droplet impact behavior on curved surfaces with a wettability difference, where efficient droplet control could be achieved by combining the features. In the present study, droplet impact experiments were conducted using copper cylinders with different circumferential wettabilities from hydrophilic to superhydrophobic, varying the impact velocity, cylinder diameter, and rotation angle. Droplets that impacted the wettability boundary showed asymmetric deformation and moved to the hydrophilic side, owing to the driving force of the wettability difference. Moreover, the droplet behavior was classified into four types: the droplet bounced off the surface, the droplet bounced off the surface and split, the droplet attached to the surface, and the droplet attached to the surface and split. The droplet behavior was estimated by using the maximum spreading width of the droplet impacted on the flat substrate. We evaluated whether the droplets attached to the surface or bounced off the surface after impact using the Weber number and rotation angle, and the estimations were in agreement with the experimental results for cylinder diameters of 4 and 6 mm. en-copyright= kn-copyright= en-aut-name=IshikawaTaku en-aut-sei=Ishikawa en-aut-mei=Taku kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamadaYutaka en-aut-sei=Yamada en-aut-mei=Yutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IsobeKazuma en-aut-sei=Isobe en-aut-mei=Kazuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HoribeAkihiko en-aut-sei=Horibe en-aut-mei=Akihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Novel pulmonary abdominal normothermic regional perfusion circuit for simultaneous in-donor evaluation and preservation of lungs and abdominal organs in donation after circulatory death en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective To overcome limitations of traditional ex vivo lung perfusion (EVLP) for controlled donation after circulatory death (cDCD) lungs, this study aimed to evaluate a novel pulmonary abdominal normothermic regional perfusion (PANRP) technique, which we uniquely designed, for in situ assessment of lungs from cDCD donors.
Methods We modified the abdominal normothermic regional perfusion circuit for simultaneous lung and abdominal organ assessment using independent extracorporeal membrane oxygenation components. Blood was oxygenated via a membrane oxygenator and returned to the body, with pulmonary flow adjusted to maintain pressure? Results PANRP maintained stable lung function, with P/F ratios above 300, and preserved abdominal organ parameters, including stable AST, ALT, BUN, and Cr levels. Adequate urine output was observed, indicating normal renal function. Pulmonary artery pressure remained? Conclusions PANRP offers a promising alternative to traditional EVLP for cDCD lung evaluation, allowing in situ assessment of multiple organs simultaneously. This approach may overcome logistical and economic challenges associated with ex vivo techniques, enabling a more efficient evaluation process. Further studies are warranted to confirm its clinical applicability and impact on long-term outcomes. en-copyright= kn-copyright= en-aut-name=TanakaShin en-aut-sei=Tanaka en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UmedaMasashi en-aut-sei=Umeda en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UjikeHiroyuki en-aut-sei=Ujike en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=RyukoTsuyoshi en-aut-sei=Ryuko en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TomiokaYasuaki en-aut-sei=Tomioka en-aut-mei=Yasuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyoshiKentaroh en-aut-sei=Miyoshi en-aut-mei=Kentaroh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkazakiMikio en-aut-sei=Okazaki en-aut-mei=Mikio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SugimotoSeiichiro en-aut-sei=Sugimoto en-aut-mei=Seiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of General Thoracic and Breast and Endocrinological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=2 en-affil=Department of General Thoracic and Breast and Endocrinological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=3 en-affil=Department of General Thoracic Surgery, Shimane University Graduate School of Medicine kn-affil= affil-num=4 en-affil=Department of General Thoracic and Breast and Endocrinological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=5 en-affil=Department of General Thoracic and Breast and Endocrinological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=6 en-affil=Department of General Thoracic and Breast and Endocrinological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=7 en-affil=Department of General Thoracic and Breast and Endocrinological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=8 en-affil=Department of General Thoracic and Breast and Endocrinological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=9 en-affil=Department of General Thoracic and Breast and Endocrinological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= en-keyword=Lung preservation kn-keyword=Lung preservation en-keyword=Donation after circulatory death kn-keyword=Donation after circulatory death en-keyword=Abdominal normothermic regional perfusion kn-keyword=Abdominal normothermic regional perfusion END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰œ•t en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page=193 end-page=193 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ƒZƒ“ƒ^[•ñ“Še—v—Ì en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page=185 end-page=192 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Ž‘—¿ : 2020`2022”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page=33 end-page=184 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰^‰c : 2020`2022”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page=29 end-page=31 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=’nˆæ˜AŒg : 2020`2022”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page=15 end-page=28 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ŽŽŒ±Œ¤‹† : 2020`2022”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page=1 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‹³ˆç : 2020`2022”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=8502 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Age-specific assessment of initial hemoglobin levels and shock index for predicting life-saving interventions in pediatric blunt liver and spleen injuries en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study aimed to evaluate the effectiveness of combining initial hemoglobin levels with the shock index for predicting the need for life-saving interventions (LSI) in pediatric patients with blunt liver and spleen injuries (BLSI), specifically tailored to different age groups. This was a multicenter retrospective cohort study of pediatric patients with BLSI in Japan. The area under the receiver operating characteristic curve (AUROC) were used to assess predictive accuracy. The study included 1,370 patients. LSI was required in 59 of 247 (23.9%) aged 1 to 6 years, 100 of 402 (24.9%) aged 7 to 12 years, and 125 of 297 (42.1%) patients aged 13 to 16 years. Within each specific age group, the predictability was categorized as fair and appeared higher than that of the entire cohort or when using either parameter alone. Notably, in the 1 to 6-year age group, the combined values showed the highest predictability, which was statistically superior to the shock index alone (AUROC of 0.770 vs. 0.671, P = 0.025). Tailoring initial hemoglobin levels and shock index to specific age groups enhances predictability of LSI in pediatric BLSI, showing a fair level of predictive accuracy. en-copyright= kn-copyright= en-aut-name=YumotoTetsuya en-aut-sei=Yumoto en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ObaraTakafumi en-aut-sei=Obara en-aut-mei=Takafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HongoTakashi en-aut-sei=Hongo en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IidaAtsuyoshi en-aut-sei=Iida en-aut-mei=Atsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TsukaharaKohei en-aut-sei=Tsukahara en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KatsuraMorihiro en-aut-sei=Katsura en-aut-mei=Morihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KondoYutaka en-aut-sei=Kondo en-aut-mei=Yutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YasudaHideto en-aut-sei=Yasuda en-aut-mei=Hideto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KushimotoShigeki en-aut-sei=Kushimoto en-aut-mei=Shigeki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=NaitoHiromichi en-aut-sei=Naito en-aut-mei=Hiromichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NakaoAtsunori en-aut-sei=Nakao en-aut-mei=Atsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=SHIPPs Study Group en-aut-sei=SHIPPs Study Group en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Surgery, Okinawa Chubu Hospital kn-affil= affil-num=7 en-affil=Department of Emergency and Critical Care Medicine, Juntendo University Urayasu Hospital kn-affil= affil-num=8 en-affil=Department of Emergency and Critical Care Medicine, Jichi Medical University Saitama Medical Center kn-affil= affil-num=9 en-affil=Division of Emergency and Critical Care Medicine, Tohoku University Graduate School of Medicine kn-affil= affil-num=10 en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=13 en-affil= kn-affil= en-keyword=Abdominal injuries kn-keyword=Abdominal injuries en-keyword=Blood transfusions kn-keyword=Blood transfusions en-keyword=Hemoglobin kn-keyword=Hemoglobin en-keyword=Hemostasis kn-keyword=Hemostasis en-keyword=Shock index kn-keyword=Shock index END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=1 article-no= start-page=1757 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250224 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Keratinocyte-driven dermal collagen formation in the axolotl skin en-subtitle= kn-subtitle= en-abstract= kn-abstract=Type I collagen is a major component of the dermis and is formed by dermal fibroblasts. The development of dermal collagen structures has not been fully elucidated despite the major presence and importance of the dermis. This lack of understanding is due in part to the opacity of mammalian skin and it has been an obstacle to cosmetic and medical developments. We reveal the process of dermal collagen formation using the highly transparent skin of the axolotl and fluorescent collagen probes. We clarify that epidermal cells, not dermal fibroblasts, contribute to dermal collagen formation. Mesenchymal cells (fibroblasts) play a role in modifying the collagen fibers already built by keratinocytes. We confirm that collagen production by keratinocytes is a widely conserved mechanism in other model organisms. Our findings warrant a change in the current consensus about dermal collagen formation and could lead to innovations in cosmetology and skin medication. en-copyright= kn-copyright= en-aut-name=OhashiAyaka en-aut-sei=Ohashi en-aut-mei=Ayaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakamotoHirotaka en-aut-sei=Sakamoto en-aut-mei=Hirotaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KurodaJunpei en-aut-sei=Kuroda en-aut-mei=Junpei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KondoYohei en-aut-sei=Kondo en-aut-mei=Yohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KameiYasuhiro en-aut-sei=Kamei en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NonakaShigenori en-aut-sei=Nonaka en-aut-mei=Shigenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=FurukawaSaya en-aut-sei=Furukawa en-aut-mei=Saya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamamotoSakiya en-aut-sei=Yamamoto en-aut-mei=Sakiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SatohAkira en-aut-sei=Satoh en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Graduate School of Environment, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environment, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Frontier Biosciences, Osaka University kn-affil= affil-num=4 en-affil=Center for One Medicine Innovative Translational Research (COMIT), Nagoya University kn-affil= affil-num=5 en-affil=Laboratory for Biothermology, National Institute for Basic Biology kn-affil= affil-num=6 en-affil=The Graduate University for Advanced Studies (SOKENDAI) kn-affil= affil-num=7 en-affil=Graduate School of Environment, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=8 en-affil=Graduate School of Environment, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=9 en-affil=Graduate School of Environment, Life, Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=7506 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250303 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A glucocorticoid-regulating molecule, Fkbp5, may interact with mitogen-activated protein kinase signaling in the organ of Corti of mice cochleae en-subtitle= kn-subtitle= en-abstract= kn-abstract=FKBP5 is a 51-Da FK506-binding protein and member of the immunophilin family involved in controlling the signaling of glucocorticoid receptor from the cytosol to nucleus. Fkbp5 has previously been shown to be expressed in murine cochlear tissue, including the organ of Corti (i.e., the sensory epithelium of the cochlea). Fkbp5-/- mice as used in this study show hearing loss in the low-frequency (8-kHz) range and click-evoked auditory brainstem response (ABR) threshold compared to wild-type mice. Both Fkbp5-/- and wild-type mice showed hearing loss at all frequencies and click-ABR thresholds at 24 h and 14 days following acoustic overexposure (AO). Tissues of the organ of Corti were subjected to RNA sequencing and KEGG pathway analysis. In Fkbp5-/- mice before AO, the mitogen-activated protein kinase (MAPK) signaling pathway was dysregulated compared to wild-type mice. In wild-type mice at 12 h following AO, the most significantly modulated KEGG pathway was the TNF signaling pathway and major MAPK molecules p38 and Jun were involved in the TNF signaling pathway. In Fkbp5-/- mice at 12 h following AO, the MAPK signaling pathway was dysregulated compared to wild-type mice following AO. In conclusion, Fkbp5 interacts with MAPK signaling in the organ of Corti in mice cochleae. en-copyright= kn-copyright= en-aut-name=SatoAsuka en-aut-sei=Sato en-aut-mei=Asuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OmichiRyotaro en-aut-sei=Omichi en-aut-mei=Ryotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MaedaYukihide en-aut-sei=Maeda en-aut-mei=Yukihide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AndoMizuo en-aut-sei=Ando en-aut-mei=Mizuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=The organ of Corti kn-keyword=The organ of Corti en-keyword=Acoustic trauma kn-keyword=Acoustic trauma en-keyword=RNA sequencing kn-keyword=RNA sequencing en-keyword=51-Da FK506-binding protein kn-keyword=51-Da FK506-binding protein en-keyword=Mitogen-activated protein kinase signaling kn-keyword=Mitogen-activated protein kinase signaling en-keyword=Tumor necrosis factor signaling kn-keyword=Tumor necrosis factor signaling END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page=iv end-page=v dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page=i end-page=iii dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=˜ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ꎓ¡–Ms kn-aut-sei=ꎓ¡ kn-aut-mei=–Ms aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw”_Šw•”•‘®ŽR—zŒ—ƒtƒB[ƒ‹ƒh‰ÈŠwƒZƒ“ƒ^[ END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž† en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=752 cd-vols= no-issue= article-no= start-page=151481 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Discovery of myeloid zinc finger (MZF) 1 nuclear bodies en-subtitle= kn-subtitle= en-abstract= kn-abstract=Myeloid zinc finger 1 (MZF1) is a multifaceted transcription factor that can act either as a transcriptional activator or a gene repressor. We examined its production of nuclear bodies (NBs) and subcellular localization. Proteomic and protein?protein interaction analysis were used to identify its cofactors and interactions. These revealed the presence of MZF1-NBs (intranuclear oligomers containing MZF1). MZF-NBs are similar to some other nuclear bodies, notably promyelocytic leukemia (PML) -NBs in terms of size and morphology. However the two structures appear to be different. MZF-NBs and PML-NBs were found to associate in the nucleus. Both MZF1 and PML are SUMO1-SUMOylated in PC-3 cells. Sumoylated MZF1 can interact with proteins containing SUMO-interaction motifs (SIM) through SUMO-SIM interaction. Interactome analysis revealed that its NBs participate in the stress response (TPR and UBAP2L), protein folding (CALR and ANKRD40), transcription, post-translational modification (TRIM33, ACOT7, CAMK2D, and CAMK2G), and RNA binding (ALURBP and CPSF5). en-copyright= kn-copyright= en-aut-name=EguchiTakanori en-aut-sei=Eguchi en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=CalderwoodStuart K. en-aut-sei=Calderwood en-aut-mei=Stuart K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Division of Molecular and Cellular Biology, Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School kn-affil= en-keyword=Myeloid zinc finger 1 kn-keyword=Myeloid zinc finger 1 en-keyword=MZF1 kn-keyword=MZF1 en-keyword=Nuclear body kn-keyword=Nuclear body en-keyword=PML kn-keyword=PML en-keyword=Sumoylation kn-keyword=Sumoylation en-keyword=SCAN domain protein kn-keyword=SCAN domain protein END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=1 end-page=60 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Annual report / Institute of Plant Science and Resources, Okayama University kn-title=‰ªŽR‘åŠwŽ‘Œ¹A•¨‰ÈŠwŒ¤‹†Š•ñ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute of Plant Science and Resources, Okayama University en-aut-sei=Institute of Plant Science and Resources, Okayama University en-aut-mei= kn-aut-name=‰ªŽR‘åŠwŽ‘Œ¹A•¨‰ÈŠwŒ¤‹†Š kn-aut-sei=‰ªŽR‘åŠwŽ‘Œ¹A•¨‰ÈŠwŒ¤‹†Š kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=— •\Ž†E‰p•¶–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰œ•t en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=81 end-page=94 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Building a Task Bank to Enhance Task-Supported Language Teaching : Tailoring Task Difficulty to Match Proficiency Levels of Japanese Language Learners kn-title=ƒ^ƒXƒNŽx‰‡Œ^Žw“±‚ðŽx‰‡‚·‚éƒ^ƒXƒNEƒoƒ“ƒN‚Ì\’z‚ð–ÚŽw‚µ‚Ä\“ú–{ŒêŠwKŽÒ‚ÌKn“x‚ɇ‚킹‚½ƒ^ƒXƒN‚Ì“ïˆÕ“x’²®\ en-subtitle= kn-subtitle= en-abstract=This paper reports on the creation and practice of using tasks for task-supported language teaching (TSLT). While focusing on TSLT, in which tasks are incorporated into the existing curriculum as a supplement, the aim is to construct a task bank to support the transition from PPP (Presentation-Practice-Production) classes to TSLT. The results of the analysis on the changes in utterances during tasks with different levels of difficulty showed that (1) the number of utterances did not increase in proportion to the number of items (elements or information) included in the task, (2) tasks with more items and higher difficulty increased the range of expressions used by Japanese learners, and (3) the goal of the task presented in the role card made it possible to predict the intention of the utterance, leading to a tendency to tolerate inaccurate utterances. kn-abstract=–{e‚Å‚ÍCƒ^ƒXƒNŽx‰‡Œ^Žw“±iTSLTj—p‚̃^ƒXƒN‚Ì쬂¨‚æ‚у^ƒXƒN‚ð—p‚¢‚½ŽÀ‘H‚ɂ‚¢‚Ä•ñ‚·‚éBŠù‘¶‚̃JƒŠƒLƒ…ƒ‰ƒ€‚Ì’†‚Ƀ^ƒXƒN‚ð•â•“I‚ÉŽæ‚è“ü‚ê‚éTSLT‚É’…–Ú‚µCPPPiPresentation-Practice-ProductionjŽö‹Æ‚©‚çTSLT‚ւ̈Ús‚ðŽx‰‡‚·‚éƒ^ƒXƒNEƒoƒ“ƒN‚Ì\’z‚ð–ÚŽw‚µC‰‹‰“ú–{Œê‹³‰È‘‚̃GƒNƒTƒTƒCƒY‚ðƒx[ƒX‚ÉC“¯‚¶ƒgƒsƒbƒN‚Å“ïˆÕ“x‚̈قȂéƒ^ƒXƒN‚Ì쬂ðs‚Á‚½B“ïˆÕ“x‚̈Ⴂ‚É‚æ‚éƒ^ƒXƒN’†‚Ì”­˜b‚̕ω»‚ð•ªÍ‚µ‚½Œ‹‰ÊCi1j”­˜b”‚ɂ‚¢‚Ă̓^ƒXƒN‚ÉŠÜ‚Ü‚ê‚逖ڔi—v‘f‚âî•ñ‚Ì”j‚Ì‘‰Á‚É”ä—Ⴕ‚Ä‘‚¦‚é‚킯‚Å‚Í‚È‚¢‚±‚ÆCi2j€–Ú”‚ª‘½‚¢“ïˆÕ“x‚ª‚‚¢ƒ^ƒXƒN‚Å‚ÍC“ú–{ŒêŠwKŽÒ‚Ì•\Œ»‚ÌŽg—p•‚ªL‚ª‚邱‚ÆCi3jƒ^ƒXƒN‚̃S[ƒ‹‚ªƒ[ƒ‹ƒJ[ƒh‚É‚Ä’ñŽ¦‚³‚ê‚Ä‚¢‚邱‚Æ‚É‚æ‚èC”­˜bˆÓ}‚Ì—\‘ª‚ª‰Â”\‚É‚È‚èC•s³Šm‚È”­˜b‚ª‹–—e‚³‚ê‚éŒXŒü‚ª‚ ‚邱‚Æ‚ªŽ¦‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=SUESHIGEMiwa en-aut-sei=SUESHIGE en-aut-mei=Miwa kn-aut-name=––”É”ü˜a kn-aut-sei=––”É kn-aut-mei=”ü˜a aut-affil-num=1 ORCID= affil-num=1 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ en-keyword=PPP kn-keyword=PPP en-keyword=TSLT kn-keyword=TSLT en-keyword=ƒ^ƒXƒN kn-keyword=ƒ^ƒXƒN en-keyword=€–Ú” kn-keyword=€–Ú” en-keyword=“ïˆÕ“x’²® kn-keyword=“ïˆÕ“x’²® END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=71 end-page=80 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=KIBITANGO : Development and Implementation of an Academic English Vocabulary Learning Program kn-title=‚«‚Ñ‚½‚ñ‚² \ƒAƒJƒfƒ~ƒbƒN‰p’PŒêŠwKƒvƒƒOƒ‰ƒ€‚ÌŠJ”­‚ÆŽÀ‘H•ñ\ en-subtitle= kn-subtitle= en-abstract=At Okayama University, we have developed and provided a self-study material called "Kibitango" to help students improve their academic English vocabulary. The project began in 2019, with a focus on collecting frequently used words from academic journals, resulting in a list of 1,500 words. Each word comes with explanations by project members and examples of how it is used in academic papers. The material has been available to students since the 2022 academic year. Registered students receive one word per day via email and learn through the Kibitango website. The number of users has steadily increased. Today, however, several challenges have emerged, including the need to update the word list and improve the delivery method and system. kn-abstract=‰ªŽR‘åŠw‚Å‚ÍŠwp‰pŒê‚ÌŒêœb—Í‚ðL‚΂·‚½‚ß‚ÌŽ©K‹³Þ‚Æ‚µ‚ÄAu‚«‚Ñ‚½‚ñ‚²v‚ðŠJ”­‚µŠw¶‚É’ñ‹Ÿ‚µ‚Ä‚¢‚éB2019”N‚©‚çŠJ”­‚Ì‚½‚߂̃vƒƒWƒFƒNƒg‚ðŠJŽn‚µAŠwpŽGŽ‚©‚ç•po’PŒê‚ðŽûW‚µ1500Œê‚̃ŠƒXƒg‚ð쬂µ‚½B’PŒê‚ɂ͈Ӗ¡E”­‰¹‚È‚Ç‚ÌŠî‘bî•ñˆÈŠO‚ÉAƒvƒƒWƒFƒNƒgƒƒ“ƒo[‚É‚æ‚é‰ðà‚âŽÀۂɂǂ̂悤‚ÉŠwp˜_•¶’†‚ÉŽg—p‚³‚ê‚Ä‚¢‚é‚©‚ÌŽÀ—á‚ð•t‚µ‚Ä‚¢‚éBŠw¶‚Ö‚Ì’ñ‹Ÿ‚Í2022”N“x‚©‚ç‚ÅA“o˜^‚µ‚½Šw¶‚Ƀ[ƒ‹‚ňê“úˆê’PŒê”zM‚µAê—pƒEƒFƒbƒuƒTƒCƒg‚ÅŠwK‚³‚¹‚é‚Æ‚¢‚¤ƒVƒXƒeƒ€‚Å‚ ‚éB—˜—pŽÒ‚à‡’²‚É‘‚¦‚Ä‚¢‚éBŠJ”­ŠJŽn‚©‚ç‚T”NA’ñ‹Ÿ‚©‚ç‚Q”NŒo‰ß‚µA’PŒêƒŠƒXƒg‚̃Aƒbƒvƒf[ƒg‚â’ñ‹Ÿ•û–@EƒVƒXƒeƒ€‚̉ü‘P‚Ȃljۑè‚à–¾‚ç‚©‚É‚È‚Á‚Ä‚¢‚éB en-copyright= kn-copyright= en-aut-name=IGARASHIMasumi en-aut-sei=IGARASHI en-aut-mei=Masumi kn-aut-name=ŒÜ\—’”ü kn-aut-sei=ŒÜ\—’ kn-aut-mei=”ü aut-affil-num=1 ORCID= en-aut-name=OGINOMasaru en-aut-sei=OGINO en-aut-mei=Masaru kn-aut-name=‰¬–ìŸ kn-aut-sei=‰¬–ì kn-aut-mei=Ÿ aut-affil-num=2 ORCID= en-aut-name=OTOSHIJunko en-aut-sei=OTOSHI en-aut-mei=Junko kn-aut-name=‘å”N‡Žq kn-aut-sei=‘å”N kn-aut-mei=‡Žq aut-affil-num=3 ORCID= en-aut-name=TERANISHIMasako en-aut-sei=TERANISHI en-aut-mei=Masako kn-aut-name=Ž›¼‰ëŽq kn-aut-sei=Ž›¼ kn-aut-mei=‰ëŽq aut-affil-num=4 ORCID= en-aut-name=YOSHIDAAzumi en-aut-sei=YOSHIDA en-aut-mei=Azumi kn-aut-name=‹g“cˆÀ“Ü kn-aut-sei=‹g“c kn-aut-mei=ˆÀ“Ü aut-affil-num=5 ORCID= en-aut-name=KENMOTSUYoshi en-aut-sei=KENMOTSU en-aut-mei=Yoshi kn-aut-name=™›Ži kn-aut-sei=™›Ž kn-aut-mei=i aut-affil-num=6 ORCID= affil-num=1 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ affil-num=2 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ affil-num=3 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ affil-num=4 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ affil-num=5 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ affil-num=6 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ en-keyword=ŠwpŒêœb kn-keyword=ŠwpŒêœb en-keyword=‰pŒêŒêœb—Í kn-keyword=‰pŒêŒêœb—Í en-keyword=Ž©K‹³Þ kn-keyword=Ž©K‹³Þ en-keyword=‹³ÞŠJ”­ kn-keyword=‹³ÞŠJ”­ END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=49 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Online Exchange Program between Sungkyunkwan University,Jilin University,and Okayama University : Practice Report kn-title=¬‹ÏŠÙE‹g—Ñ‘åŠwŒð—¬ƒvƒƒOƒ‰ƒ€yƒIƒ“ƒ‰ƒCƒ“zŽÀ‘H•ñ en-subtitle= kn-subtitle= en-abstract=The Institute for Promotion of Education and Campus Life at Okayama University hosted 5th annual Sungkyunkwan University (South Korea) and Jilin University (China) Exchange Program online. This program convened Sungkyunkwan University students, Jilin University students, and Okayama University students to engage in discussion, exploration, and presentation of cultural topics. While participants used Japanese as their common language, they addressed and overcame communication challenges that arise due to language barriers and cultural differences. The current report explores the programfs significance for global citizenship education, programfs results, several issues encountered during its implementation, and actions to resolve those issues. kn-abstract=‰ªŽR‘åŠw‹³ˆç„i‹@\‰CŠO‘ŒêŒn‚ª–ˆ”N‚QŒŽ‚ɃIƒ“ƒ‰ƒCƒ“‚ÅŽÀŽ{‚µ‚Ä‚¢‚éu¬‹ÏŠÙE‹g —Ñ‘åŠwŒð—¬ƒvƒƒOƒ‰ƒ€v‚ÍA“ú’†ŠØŽOƒ•‘‚Ì‘åŠw‚ÌŠw¶‚ªA“ú–{Œê‚ð‹¤’ÊŒ¾Œê‚Æ‚µ‚ÄA•¡ ”‚Ì•¶‰»EŒ¾ŒêAŠwKŒ¾Œê‚Æ•êŒê‚̈Ⴂ‚È‚Ç‚ð•ïÛ‚µ‚½ê‚Ŷ‚¶‚éƒRƒ~ƒ…ƒjƒP[ƒVƒ‡ƒ“ã ‚Ì–â‘è‚ð‰ðŒˆ‚µ‚È‚ª‚çA—lX‚Șb‘è‚̃fƒBƒXƒJƒbƒVƒ‡ƒ“‚âƒvƒŒƒ[ƒ“ƒe[ƒVƒ‡ƒ“‚ðs‚È‚¤B –{ŽÀ‘H•ñ‚ÍA‚±‚̃vƒƒOƒ‰ƒ€‚ÌŽïŽ|‚Ƭ‰ÊA‚Ü‚½ŽÀ‘H‚É“–‚½‚Á‚Ä‚Ì—lX‚ȉۑè‚Æ‚»‚ê‚É ‘΂·‚éŽæ‚è‘g‚݂ɂ‚¢‚Ä•ñ‚µAƒRƒƒiŒã‚̑ی𗬂̈ê‚‚̃‚ƒfƒ‹‚ƂȂ邱‚Æ‚ðŠú‘Ò‚· ‚é‚à‚Ì‚Å‚ ‚éB en-copyright= kn-copyright= en-aut-name=FUJIWARAYuko en-aut-sei=FUJIWARA en-aut-mei=Yuko kn-aut-name=“¡Œ´—SŽq kn-aut-sei=“¡Œ´ kn-aut-mei=—SŽq aut-affil-num=1 ORCID= en-aut-name=AKITASetsuko en-aut-sei=AKITA en-aut-mei=Setsuko kn-aut-name=H“cߎq kn-aut-sei=H“c kn-aut-mei=ߎq aut-affil-num=2 ORCID= en-aut-name=ISHIITomomi en-aut-sei=ISHII en-aut-mei=Tomomi kn-aut-name=Έä—F”ü kn-aut-sei=Έä kn-aut-mei=—F”ü aut-affil-num=3 ORCID= en-aut-name=SATOMiho en-aut-sei=SATO en-aut-mei=Miho kn-aut-name=²“¡”ü•ä kn-aut-sei=²“¡ kn-aut-mei=”ü•ä aut-affil-num=4 ORCID= affil-num=1 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ affil-num=2 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw”ñí‹ÎuŽt affil-num=3 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ affil-num=4 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw”ñí‹ÎuŽt en-keyword=ŽO‘ŠÔŒð—¬ kn-keyword=ŽO‘ŠÔŒð—¬ en-keyword=ˆÙ•¶‰»—‰ð kn-keyword=ˆÙ•¶‰»—‰ð en-keyword=•¡Œ¾ŒêE•¡•¶‰»Žå‹` kn-keyword=•¡Œ¾ŒêE•¡•¶‰»Žå‹` en-keyword=ƒCƒ“ƒNƒ‹[ƒWƒ‡ƒ“ kn-keyword=ƒCƒ“ƒNƒ‹[ƒWƒ‡ƒ“ en-keyword=ƒAƒNƒeƒBƒuƒ‰[ƒjƒ“ƒO kn-keyword=ƒAƒNƒeƒBƒuƒ‰[ƒjƒ“ƒO END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=33 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Old Stories, Original Retellings : The Heike-related Tales in the Repertory of the Blind Biwa Players of Kyushu en-subtitle= kn-subtitle= en-abstract= kn-abstract=While higobiwa, the blind biwa players' tradition of Kyushu, is regarded as a historically distinctive genre, its evolution has been influenced by interactions with other storytelling traditions. It is evident that higobiwa borrowed stories from other genres and adapted them to its own distinctive narrative style. The findings of this research focused on the Heike-related tales reveal significant similarities between the tales of Ichi-no-Tani and Ko-Atsumori in the blind biwa players' tradition and Ko-Atsumori in the kojoruri tradition. These parallels suggest a shared narrative lineage between these two performance genres, prompting a reevaluation of our understanding of the transmission and evolution of oral narratives within the blind biwa players' tradition of Kyushu and shedding light on the dynamic nature and the interconnectedness of different performance traditions within Japan. en-copyright= kn-copyright= en-aut-name=KHALMIRZAEVASaida en-aut-sei=KHALMIRZAEVA en-aut-mei=Saida kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Institute of Global Human Resource Development, Okayama University kn-affil= en-keyword=higobiwa kn-keyword=higobiwa en-keyword=the blind biwa players' tradition kn-keyword=the blind biwa players' tradition en-keyword=kojoruri kn-keyword=kojoruri en-keyword=Ichi-no-Tani kn-keyword=Ichi-no-Tani en-keyword=Ko-Atsumori kn-keyword=Ko-Atsumori END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=13 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Research on Factors Promoting Study in Japan : Cases of International Students from South-East Asia kn-title=“ú–{‚Ö‚Ì—¯Šw‚ð‘£i‚·‚é—vˆö‚ÉŠÖ‚·‚錤‹†@|“Œ“ìƒAƒWƒA‚©‚ç‚Ì—¯Šw¶‚ðŽ–—á‚Æ‚µ‚Ä| en-subtitle= kn-subtitle= en-abstract=In this study, international students from Southeast Asia were asked, 'Why did you decide to study in Japan?' and the information was collected through semi-structured interviews. The results showed that (i) international students' image of Japan, (ii) parents' image of Japan, (iii) the availability of scholarships, (iv) affordable tuition fees and living costs, and (v) the existence of a community of people from the country of origin., were found to be important. It was assumed that some of this information and image is formed by the international students' (1) satisfaction with their study destination, (2) opportunities to interact with Japanese people, (3) ease of living in Japan, (4) Japanese language level, (5) understanding of Japanese culture, etc., and is reinforced through word of mouth and the internet. Therefore, supporting the creation of these environments will create a positive image of studying in Japan and increase the number of students from Southeast Asia. kn-abstract=@–{Œ¤‹†‚Å‚ÍA“Œ“ìƒAƒWƒA‚©‚ç—¯Šw‚µ‚Ä‚¢‚é—¯Šw¶15l‚ð‘ÎÛ‚Æ‚µ‚Äu‚È‚º“ú–{‚É—¯Šw‚µ‚½‚Ì‚©HvA”¼\‘¢‰»ƒCƒ“ƒ^ƒrƒ…[‚É‚æ‚èî•ñ‚ðŽûW‚µ‚½B‚»‚ÌŒ‹‰ÊA(i) —¯Šw¶‚Ì“ú–{‚ɑ΂·‚éƒCƒ[ƒWA(ii) •ÛŒìŽÒ‚Ì“ú–{‚ɑ΂·‚éƒCƒ[ƒWA(iii) §Šw‹à‚Ì‹@‰ïA(iv) Ž„”ï—¯Šw‚ª‰Â”\‚ÈŠw”ïE¶Šˆ”ƒxƒ‹A(v) og‘ƒRƒ~ƒ…ƒjƒeƒB[‚Ì—L–³A‚ªd—v‚Å‚ ‚邱‚Æ‚ª•ª‚©‚Á‚½B‚±‚ê‚ç‚Ìî•ñ‚âƒCƒ[ƒW‚̈ꕔ‚ÍA(1) —¯Šwæ‚Å‚Ì–ž‘«“xA(2) “ú–{l‚Ƃ̌𗬋@‰ïA(3) ¶Šˆ‚Ì‚µ‚â‚·‚³A(4) —¯Šw¶‚Ì“ú–{ŒêƒŒƒxƒ‹A(5) “ú–{•¶‰»‚ɑ΂·‚闉𓙂ɂæ‚Á‚ÄŒ`¬‚³‚êAƒƒRƒ~‚âƒCƒ“ƒ^[ƒlƒbƒg‚ð’Ê‚¶‚Ä‹­‰»‚³‚ê‚邱‚Æ‚ª„‘ª‚³‚ꂽB‚æ‚Á‚ÄAã‹L‚Ì€–Ú‚É’…–Ú‚µA—¯Šw¶‚Ì–ž‘«“x“™‚ðŒüコ‚¹‚邽‚߂̊‹«‚­‚è‚ðŽx‰‡‚µ‚Ä‚¢‚­‚±‚Æ‚ªA“ú–{—¯Šw‚ɑ΂·‚éƒvƒ‰ƒX‚̃Cƒ[ƒW‚ðì‚èA“Œ“ìƒAƒWƒA‚©‚ç‚Ì—¯Šw¶‘‚ɂ‚Ȃª‚Á‚Ä‚¢‚­‚Æl‚¦‚ç‚ꂽB en-copyright= kn-copyright= en-aut-name=INAMORITakao en-aut-sei=INAMORI en-aut-mei=Takao kn-aut-name=ˆîXŠx‰› kn-aut-sei=ˆîX kn-aut-mei=Šx‰› aut-affil-num=1 ORCID= affil-num=1 en-affil=Institute of Global Human Resource Development, Okayama University kn-affil=‰ªŽR‘åŠwƒOƒ[ƒoƒ‹lވ笉@ en-keyword=“ú–{—¯Šw kn-keyword=“ú–{—¯Šw en-keyword=—¯Šw¶ kn-keyword=—¯Šw¶ en-keyword=“Œ“ìƒAƒWƒA kn-keyword=“Œ“ìƒAƒWƒA en-keyword=ASEAN kn-keyword=ASEAN en-keyword=‘£i—vˆö kn-keyword=‘£i—vˆö END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=1 end-page=12 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Relationship between Sexual Minorities and Attention Deficit Hyperactivity Disorder (ADHD) kn-title=ƒZƒNƒVƒ…ƒAƒ‹ƒ}ƒCƒmƒŠƒeƒB‚Æ”­’BáŠQ‚ÌADHD“Á«‚Æ‚ÌŠÖ˜A en-subtitle= kn-subtitle= en-abstract=To reveal the association between various sexual minority groups and the developmental disorder (ADHD), a web-based survey was conducted. Adults aged 18 years and over were surveyed and 11018 people (mean age 39.47 years) responded. The Adult ADHD Self-Rating Scale was used. For each sexual minority, a t-test was performed for ADHD scores and subscale scores of ginattention,h ghyperactivity,h and gimpulsivity,h and a x2 test was performed for the number of persons above the cut-off. All sexual minority groups had significantly higher ADHD and subscale scores and significantly more people above the cut-off scores, so the close association was evident. There was no significant difference in ADHD scores or numbers of persons between transwomen and transmen. kn-abstract=@—lX‚ȃZƒNƒVƒ…ƒAƒ‹ƒ}ƒCƒmƒŠƒeƒB‚Æ”­’BáŠQ‚ÌADHDiAttention Deficit Hyperactivity Disorderj‚Æ‚ÌŠÖ˜A‚𖾂炩‚É‚·‚邽‚ßC WEB’²¸‚ðs‚Á‚½B18ΈÈã‚̬l‚ð‘ÎÛ‚Æ‚µC11,018li•½‹Ï”N39.47Îj‚©‚ç‰ñ“š‚𓾂½BADHD‚𑪂鎿–⎆‚Íu¬lŠúADHDŒŸ¸iA-ADHDjv‚ðŽg—p‚µ‚½BƒZƒNƒVƒ…ƒAƒ‹ƒ}ƒCƒmƒŠƒeƒB‚²‚Æ‚ÉC ADHD“¾“_‚ƉºˆÊŽÚ“xu•s’ˆÓvu‘½“®«vuÕ“®«v“¾“_‚ɂ‚¢‚ÄtŒŸ’èCƒJƒbƒgƒIƒt54“_ˆÈã‚Ìl”‚ɂ‚¢‚Äx2ŒŸ’è‚ðs‚Á‚½B‘S‚ẴZƒNƒVƒ…ƒAƒ‹ƒ}ƒCƒmƒŠƒeƒB‚Å—LˆÓ‚ÉADHD‚ƉºˆÊŽÚ“x“¾“_‚ª‚‚­CƒJƒbƒgƒIƒt“¾“_ˆÈã‚Ìl”‚à—LˆÓ‚É‘½‚©‚Á‚½B‚È‚¨ƒgƒ‰ƒ“ƒXƒE[ƒ}ƒ“‚ƃgƒ‰ƒ“ƒXƒ}ƒ“‚ÅADHD“¾“_‚âl”‚É—LˆÓ‚È·‚ÍŒ©‚ç‚ê‚È‚©‚Á‚½BˆÈã‚©‚çCƒZƒNƒVƒ…ƒAƒ‹ƒ}ƒCƒmƒŠƒeƒB‚ÆADHD‚Í–§Ú‚ÉŠÖŒW‚µ‚Ä‚¢‚鎖‚ª–¾‚ç‚©‚Æ‚È‚Á‚½B en-copyright= kn-copyright= en-aut-name=MATSUIMegumi en-aut-sei=MATSUI en-aut-mei=Megumi kn-aut-name=¼ˆä‚ß‚®‚Ý kn-aut-sei=¼ˆä kn-aut-mei=‚ß‚®‚Ý aut-affil-num=1 ORCID= affil-num=1 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ en-keyword=ƒZƒNƒVƒ…ƒAƒ‹ƒ}ƒCƒmƒŠƒeƒB kn-keyword=ƒZƒNƒVƒ…ƒAƒ‹ƒ}ƒCƒmƒŠƒeƒB en-keyword=”­’BáŠQ kn-keyword=”­’BáŠQ en-keyword=ADHD kn-keyword=ADHD en-keyword=’ˆÓŒ‡”@E‘½“®Ç kn-keyword=’ˆÓŒ‡”@E‘½“®Ç END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž†E–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=5 article-no= start-page=577 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Efficacy of Oral Intake of Hydrogen-Rich Jelly Intake on Gingival Inflammation: A Double-Blind, Placebo-Controlled and Exploratory Randomized Clinical Trial en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background/Objectives: Initiation and progression of periodontal disease include oxidative stress. Systemic application of antioxidants may provide clinical benefits against periodontal disease including gingivitis. Recently, a jelly containing a high concentration of hydrogen (40 ppm) was developed. We hypothesized that oral intake of this hydrogen-rich jelly may be safe and effective on gingivitis. This clinical trial was designed to investigate the safety and efficacy of oral intake of hydrogen-rich jelly against gingival inflammation. Methods: Participants with gingivitis were instructed to orally ingest 30 g of hydrogen-rich jelly (experimental group) or placebo jelly (control group) three times a day for 14 consecutive days. The primary outcome of this trial was the percentage of bleeding on probing (BOP) sites. Secondary outcomes were oral parameters, serum reactive oxygen metabolites, antioxidant capacity, oxidative index, concentrations of cytokine (interleukin [IL]-1ƒÀ, IL-6, IL-10, IL-17, and tumor necrosis factor-alpha) in gingival crevicular fluid, and adverse events. For all parameters, Mann?Whitney U test was used for comparison between experimental and control groups. Analysis of covariance, controlling for baseline periodontal inflamed surface area, was performed to evaluate the association between the effect of the hydrogen-rich jelly and gingival inflammation. Results: In the experiment and control groups, the percentage of sites with BOP and PISA significantly decreased at the end of the experiment compared to the baseline. However, no significant differences were found between groups (p > 0.05). Conclusions: Administration of hydrogen-rich jelly for 14 days decreased gingival inflammation. However, no significant differences were identified compared to the control group. en-copyright= kn-copyright= en-aut-name=MaruyamaTakayuki en-aut-sei=Maruyama en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakayamaEiji en-aut-sei=Takayama en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TokunoShinichi en-aut-sei=Tokuno en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoritaManabu en-aut-sei=Morita en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=EkuniDaisuke en-aut-sei=Ekuni en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Oral Biochemistry, Asahi University School of Dentistry kn-affil= affil-num=3 en-affil=Graduate School of Health Innovation, Kanagawa University of Human Services kn-affil= affil-num=4 en-affil=Department of Oral Health, Takarazuka University of Medical and Health Care kn-affil= affil-num=5 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=periodontal disease kn-keyword=periodontal disease en-keyword=oxidative stress kn-keyword=oxidative stress en-keyword=hydrogen kn-keyword=hydrogen en-keyword=randomized controlled trial kn-keyword=randomized controlled trial END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue=9 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160908 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=S-nitrosylation of laforin inhibits its phosphatase activity and is implicated in Lafora disease en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recently, the relation between S-nitrosylation by nitric oxide (NO), which is over?produced under pathological conditions and neurodegenerative diseases, includingAlzheimerfs and Parkinsonfs diseases, has become a focus of attention. Although mostcases of Parkinsonfs disease are known to be caused by mutations in the Parkin gene, arecent finding has indicated that S-nitrosylation of Parkin affects its enzymatic activityand leads to the Parkinsonian phenotype. Therefore, it is important to understand thefunction of S-nitrosylated proteins in the pathogenesis of neurodegenerative diseases.Lafora disease (LD, OMIM 254780) is a neurodegenerative disease characterized by theaccumulation of insoluble glucans called Lafora bodies (LBs). LD is caused by mutationsin genes that encode the glucan phosphatase, Laforin, or the E3 ubiquitin ligase, Malin.In this study, we hypothesized that LD may be caused by S-nitrosylation of Laforin,which is similar to the finding that Parkinsonfs disease is caused by S-nitrosylation ofParkin. To test this hypothesis, we first determined whether Laforin was S-nitrosylatedusing a biotin switch assay, and compared the three main functions of unmodified andS-nitrosylated Laforin, namely glucan- and Malin-binding activity and phosphataseactivity. Furthermore, we examined whether the numbers of LBs were changed byNO in the cells expressing wild-type Laforin. Here, we report for the first time thatS-nitrosylation of Laforin inhibited its phosphatase activity and that LB formation wasincreased by an NO donor. Our results suggest a possible hypothesis for LD pathogenesis; that is, the decrease in phosphatase activity of Laforin by S-nitrosylation leads toincreased LB formation. Therefore, LD may be caused not only by mutations in theLaforin or Malin genes, but also by the S-nitrosylation of Laforin. en-copyright= kn-copyright= en-aut-name=ToyotaRikako en-aut-sei=Toyota en-aut-mei=Rikako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HonjoYasuko en-aut-sei=Honjo en-aut-mei=Yasuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ImajoRisa en-aut-sei=Imajo en-aut-mei=Risa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SatohAyano en-aut-sei=Satoh en-aut-mei=Ayano kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University; Research Institute for Radiation Biology and Medicine, Hiroshima University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University; Research Institute for Radiation Biology and Medicine, Hiroshima University kn-affil= affil-num=4 en-affil=Graduate School of Natural Science and Technology, Okayama University; Research Institute for Radiation Biology and Medicine, Hiroshima University kn-affil= en-keyword=S-Nitrosylation Of Laforin kn-keyword=S-Nitrosylation Of Laforin en-keyword=Post-Translational Modification kn-keyword=Post-Translational Modification en-keyword=Nitrosylation kn-keyword=Nitrosylation en-keyword=Phosphatase kn-keyword=Phosphatase en-keyword=Glucan-Binding kn-keyword=Glucan-Binding END start-ver=1.4 cd-journal=joma no-vol=195 cd-vols= no-issue= article-no= start-page=123743 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202503 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Utility of Surgical Simulation for Tubular Retractor Surgery Using Three-Dimensional Printed Intraventricular Tumor Models: Case Series en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective: The utility of the tubular retractor for deep-seated tumors, including intraventricular tumors, has recently been reported. However, the surgical fieldfs depth and narrowness can lead to blind spots, and it is crucial to prevent damage to the cortex and white matter fibers in eloquent areas. Therefore, preoperative simulation is critical for tubular retractor surgery. In this study, we investigated the benefits of threedimensional (3D)-printed intraventricular tumor models for tubular retractor surgery.
Methods: Nine patients with intraventricular central neurocytoma who underwent tubular retractor surgery at our institution between March 2013 and August 2023 were retrospectively reviewed. Fusion images and 3D-printed intraventricular tumor models were developed from preoperative computed tomography (CT) and magnetic resonance imaging (MRI). The puncture points of the tubular retractor were simulated using fusion images and 3D-printed intraventricular tumor models by 11 neurosurgeons (3 experts in brain tumors, 2 experts in areas other than brain tumors, and 6 residents). The dispersion of puncture points among 8 neurosurgeons (excluding brain tumor experts) was compared in each simulation model.
Results: These cases were categorized into two groups based on the dispersion of puncture points simulated by fusion images. Puncture point dispersion was markedly smaller in all cases when using 3D-printed intraventricular tumor models compared to simulations solely based on fusion images.
Conclusions: In intraventricular tumor surgery using a tubular retractor, 3D-printed intraventricular tumor models proved more beneficial in preoperative simulation compared to fusion images. en-copyright= kn-copyright= en-aut-name=OmaeRyo en-aut-sei=Omae en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KimuraRyu en-aut-sei=Kimura en-aut-mei=Ryu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OtaniYoshihiro en-aut-sei=Otani en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HarumaJun en-aut-sei=Haruma en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SaijoTomoya en-aut-sei=Saijo en-aut-mei=Tomoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FujitaJuntaro en-aut-sei=Fujita en-aut-mei=Juntaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NishigakiShohei en-aut-sei=Nishigaki en-aut-mei=Shohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IkemachiRyosuke en-aut-sei=Ikemachi en-aut-mei=Ryosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HiranoShuichiro en-aut-sei=Hirano en-aut-mei=Shuichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IshidaJoji en-aut-sei=Ishida en-aut-mei=Joji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=FujiiKentaro en-aut-sei=Fujii en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YasuharaTakao en-aut-sei=Yasuhara en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=TanakaShota en-aut-sei=Tanaka en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=13 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=3D-printed model kn-keyword=3D-printed model en-keyword=Case series kn-keyword=Case series en-keyword=Intraventricular tumors kn-keyword=Intraventricular tumors en-keyword=Preoperative surgical simulation kn-keyword=Preoperative surgical simulation en-keyword=Tubular retractor kn-keyword=Tubular retractor END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=4 article-no= start-page=252 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250305 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Characteristics of oral mucositis in patients undergoing haploidentical stem cell transplantation with posttransplant cyclophosphamide: marked difference between busulfan and melphalan regimens en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose This study was performed to examine the effects of conditioning regimens on oral mucositis in haploidentical (haplo) donor hematopoietic stem cell transplantation (HSCT) with posttransplant cyclophosphamide (PTCy).
Methods Thirty consecutive patients (male, 23; female, 7; 18?68 years, median, 59 years) undergoing haplo-HSCT with PTCy using one of three conditioning regimens?reduced intensity conditioning (RIC)-melphalan (Mel); RIC-Busulfan (Bu); and myeloablative conditioning (MAC)-Bu?were enrolled in this study. Data on the WHO grade of oral mucositis (day???7 to?+?20) were collected retrospectively. The incidences of ulcerative and severe mucositis (Grade 2?4 and Grade 3?4, respectively) were compared between the three groups.
Results Ulcerative mucositis occurred in 0% (0/10) of patients in the RIC-Mel group, 57.1% (4/7) in the RIC-Bu group, and 100% (13/13) in the MAC-Bu group. The differences between the RIC-Mel and RIC-Bu groups and between the RIC-Bu and MAC-Bu groups were significant (all P? Conclusion The risk of oral mucositis in patients undergoing haplo-HSCT with PTCy is highest with the MAC-Bu conditioning regimen, followed by RIC-Bu, and lowest with RIC-Mel. en-copyright= kn-copyright= en-aut-name=OguraSaki en-aut-sei=Ogura en-aut-mei=Saki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SogaYoshihiko en-aut-sei=Soga en-aut-mei=Yoshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiwaraHideaki en-aut-sei=Fujiwara en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiuraRumi en-aut-sei=Miura en-aut-mei=Rumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MatsuokaKen-ichi en-aut-sei=Matsuoka en-aut-mei=Ken-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KubokiTakuo en-aut-sei=Kuboki en-aut-mei=Takuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Division of Dental Hygienist, Okayama University Hospital kn-affil= affil-num=2 en-affil=Division of Hospital Dentistry, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Division of Dental Hygienist, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Hematology, Oncology and Respiratory Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Hematology, Oncology and Respiratory Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Division of Dental Hygienist, Okayama University Hospital kn-affil= en-keyword=Oral mucositis kn-keyword=Oral mucositis en-keyword=Hematopoietic cell transplantation kn-keyword=Hematopoietic cell transplantation en-keyword=Posttransplant cyclophosphamide kn-keyword=Posttransplant cyclophosphamide en-keyword=Busulfan kn-keyword=Busulfan en-keyword=Melphalan kn-keyword=Melphalan END start-ver=1.4 cd-journal=joma no-vol=210 cd-vols= no-issue= article-no= start-page=112952 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202503 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A microfluidic paper-based analytical device that uses gelatin film to assay protease activity via time readout en-subtitle= kn-subtitle= en-abstract= kn-abstract=Food processing, detergents, and pharmaceuticals frequently employ proteases, which are enzymes that break the chemical bonds of both proteins and peptides. In this work, we developed a microfluidic paper-based analytical device (?PAD) for protease activity assays via time readout. To accomplish this, we folded the ?PAD to form layers, then inserted a water-insoluble gelatin film between the layers of paper to form the device. Lamination helps to maintain the gelatin film between the introduction zone, which is the upper layer, and the detection channel, which is the lower layer. Proteases decompose the gelatin film when it enters the introduction zone, which then allows it to flow into the detection channel. The protease activity in the sample solution determines the time required to dissolve the gelatin film, which leads to a linear relationship between the logarithm of the protease concentration and the time required to flow the solution a specific distance on the detection channel. The ?PAD was used to measure proteases in concentrations that ranged from 0.25 to 1 mg L?1 for bromelain, 2.5 to 10 mg L?1 for papain, and 1 to 8 mg L?1 for trypsin. The limits of quantification for bromelain, papain, and trypsin were 0.41, 2.7, and 9.2 mg mL?1, respectively. The relative standard deviations for bromelain were smaller than 2 % for concentrations ranging from 0.5 to 1.0 mg L?1. We compared the ?PAD to a commercially available protease activity assay kit, which relies on quenching fluorescein isothiocyanate-labeled casein. Both methods demonstrated the same order of activity: bromelain > papain > trypsin. The proposed device allowed the assay of bromelain in both pineapple pulp and juice, which were stored at room temperature. When first using the proposed device, the bromelain in the pulp gradually lost its activity, while the activity of the bromelain in the juice showed no significant change for five days. The ?PAD requires no analytical instruments for quality control and monitoring of the protease activity in food. en-copyright= kn-copyright= en-aut-name=RenJianchao en-aut-sei=Ren en-aut-mei=Jianchao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=DanchanaKaewta en-aut-sei=Danchana en-aut-mei=Kaewta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KanetaTakashi en-aut-sei=Kaneta en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Chemistry, Okayama University kn-affil= affil-num=2 en-affil=Department of Chemistry, Okayama University kn-affil= affil-num=3 en-affil=Department of Chemistry, Okayama University kn-affil= en-keyword=Microfluidic paper-based analytical device kn-keyword=Microfluidic paper-based analytical device en-keyword=Protease kn-keyword=Protease en-keyword=Enzyme assay kn-keyword=Enzyme assay en-keyword=Time readout kn-keyword=Time readout END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=3 article-no= start-page=32 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250307 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Rapid development of naked malting barley germplasm through targeted mutagenesis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Covered barley (Hordeum vulgare) has historically been preferred for malting, as the husk in this plant protects the embryo during harvest and acts as a filter during brewing. Naked barley, which is typically used as food, has the potential to be used in brewing due to recent technical advances, but the grains contain higher levels of ƒÀ-glucan and polyphenols, which are undesirable in brewing. Introducing the naked trait into brewing cultivars through crossing is time-consuming due to the need to eliminate these undesirable traits. In this study, we rapidly developed naked barley that is potentially suitable for malting by introducing targeted mutations into Nudum (NUD) using CRISPR/Cas9-mediated targeted mutagenesis. The doubled haploid line eDH120366f, which was used as the parental line, was derived from a cross between two covered malting barley cultivars. We generated CRISPR/Cas9-mediated targeted mutagenized barley harboring mutations in NUD via Agrobacterium tumefaciens-mediated transformation and confirmed the presence of mosaic mutations in one individual from among 16 T0 transformants. We sowed T1 grains exhibiting the naked trait and sequenced the NUD gene in these T1 seedlings, identifying two types of mutations. Shotgun high-throughput whole-genome sequencing confirmed the absence of the transgene in at least one nud mutant line following k-mer-based analysis. Cultivation in a closed growth chamber revealed no significant differences in agronomic traits between the nud mutants and the wild type. This study demonstrates the feasibility of rapidly developing naked barley with potential use for malting and brewing by targeting only NUD via targeted mutagenesis. en-copyright= kn-copyright= en-aut-name=HisanoHiroshi en-aut-sei=Hisano en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakaiHiroaki en-aut-sei=Sakai en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HamaokaMika en-aut-sei=Hamaoka en-aut-mei=Mika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MunemoriHiromi en-aut-sei=Munemori en-aut-mei=Hiromi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AbeFumitaka en-aut-sei=Abe en-aut-mei=Fumitaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MeintsBrigid en-aut-sei=Meints en-aut-mei=Brigid kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SatoKazuhiro en-aut-sei=Sato en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HayesPatrick M. en-aut-sei=Hayes en-aut-mei=Patrick M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=2 en-affil=Research Center for Advanced Analysis, National Agriculture and Food Research Organization kn-affil= affil-num=3 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=4 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=5 en-affil=Institute of Crop Science, National Agriculture and Food Research Organization kn-affil= affil-num=6 en-affil=Department Crop and Soil Science, Oregon State University kn-affil= affil-num=7 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=8 en-affil=Department Crop and Soil Science, Oregon State University kn-affil= en-keyword=Hordeum vulgare kn-keyword=Hordeum vulgare en-keyword=Covered (hulled) kn-keyword=Covered (hulled) en-keyword=Naked (hull-less) kn-keyword=Naked (hull-less) en-keyword=Genome editing kn-keyword=Genome editing en-keyword=CRISPR/Cas9 kn-keyword=CRISPR/Cas9 en-keyword=Transformation amenability kn-keyword=Transformation amenability END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=25 article-no= start-page=4757 end-page=4773 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Recent development of azahelicenes showing circularly polarized luminescence en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recently, a variety of circularly polarized luminescence (CPL) dyes have been developed as next-generation chiroptical materials. Helicenes, ortho-fused aromatics, have been recognized as some of the most promising CPL dyes. Although typical carbohelicenes show CPL, weak fluorescence is often emitted in the blue region. In contrast, heteroatom-embedded helicenes (heterohelicenes) can show intense fluorescence and CPL in the visible region because heteroatoms alter the electronic states of helicene frameworks. Among various heterohelicenes, nitrogen-embedded helicenes (azahelicenes) have unique features such as facile functionalization and sensitive responses to acid/base or metal ions. Furthermore, polycyclic aromatic hydrocarbons (PAHs) containing azaborine units have been recognized as excellent luminescent materials, and the helical derivatives, B,N-embedded helicenes, have been rapidly growing recently. In this feature article, we review and summarize the synthesis and chiroptical properties of azahelicenes, which are classified into imine-type and amine-type azahelicenes and B,N-embedded helicenes. CPL switching systems of azahelicenes are also reviewed. en-copyright= kn-copyright= en-aut-name=MaedaChihiro en-aut-sei=Maeda en-aut-mei=Chihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=EmaTadashi en-aut-sei=Ema en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Examining the Long-Term Impact of COVID-19-Induced Clinical Practice Changes on Problem-Solving Behaviors Among Newly Graduated Nurses: A Longitudinal Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective: This study aimed to longitudinally examine how the cancellation or modification of the clinical practicum due to COVID-19 affected the nursing practice competence of newly graduated nurses in Japan.
Methods: A survey was conducted across three periods-June, September, and December 2022-to seek responses from participants. A total of 73 participants (two men and 71 women) who responded in all periods were included in the analysis. The survey included questions on the impact of the integrated and specific clinical practicums, including a self-assessment scale for nursing problem-solving behaviors.
Results: During all response periods, those whose practicums were entirely clinical scored significantly higher in nursing problem-solving behaviors. Furthermore, by December, "psychological support to patients for overcoming challenges" improved alongside the clinical experience of newly graduated nurses. However, their practical skills related to aggregating information, identifying improvements in nursing problems, facilitating smooth patient interactions, and individualizing assistance were challenging to improve along with clinical experience.
Conclusion: This study revealed that canceling or modifying the clinical practicum owing to COVID-19 impacted the problem-solving behaviors of newly graduated nurses. en-copyright= kn-copyright= en-aut-name=OhueTakashi en-aut-sei=Ohue en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhueYuka en-aut-sei=Ohue en-aut-mei=Yuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HaradaHiroe en-aut-sei=Harada en-aut-mei=Hiroe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences and Faculty of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Faculty of Nursing, Department of Nursing, Hyogo University kn-affil= affil-num=3 en-affil=Faculty of Nursing, Department of Nursing, Hyogo University kn-affil= en-keyword=COVID-19 kn-keyword=COVID-19 en-keyword=clinical practice kn-keyword=clinical practice en-keyword=newly graduated nurses kn-keyword=newly graduated nurses en-keyword=nursing practice skills kn-keyword=nursing practice skills en-keyword=longitudinal study kn-keyword=longitudinal study END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=5 article-no= start-page=2421 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250224 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Deep Reinforcement Learning for Dynamic Pricing and Ordering Policies in Perishable Inventory Management en-subtitle= kn-subtitle= en-abstract= kn-abstract=Perishable goods have a limited shelf life, and inventory should be discarded once it exceeds its shelf life. Finding optimal inventory management policies is essential since inefficient policies can lead to increased waste and higher costs. While many previous studies assume the perishable inventory is processed following the First In, First Out rule, it does not reflect customer purchasing behavior. In practice, customers' preferences are influenced by the shelf life and price of products. This study optimizes inventory and pricing policies for a perishable inventory management problem considering age-dependent probabilistic demand. However, introducing dynamic pricing significantly increases the complexity of the problem. To tackle this challenge, we propose eliminating irrational actions in dynamic programming without sacrificing optimality. To solve this problem more efficiently, we also implement a deep reinforcement learning algorithm, proximal policy optimization, to solve this problem. The results show that dynamic programming with action reduction achieved an average of 63.1% reduction in computation time compared to vanilla dynamic programming. In most cases, proximal policy optimization achieved an optimality gap of less than 10%. Sensitivity analysis of the demand model revealed a negative correlation between customer sensitivity to shelf lives or prices and total profits. en-copyright= kn-copyright= en-aut-name=NomuraYusuke en-aut-sei=Nomura en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=LiuZiang en-aut-sei=Liu en-aut-mei=Ziang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NishiTatsushi en-aut-sei=Nishi en-aut-mei=Tatsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=reinforcement learning kn-keyword=reinforcement learning en-keyword=supply chain kn-keyword=supply chain en-keyword=inventory management kn-keyword=inventory management en-keyword=perishable inventory kn-keyword=perishable inventory en-keyword=dynamic pricing kn-keyword=dynamic pricing END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=1 article-no= start-page=36 end-page=43 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Evaluation of the temporal behavior of fulvic acid iron in Asahi River, Okayama, Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=Iron is essential for biogeochemical processes in aquatic ecosystems, but its riverine concentration can be affected by environmental conditions. This study assessed weekly fulvic acid iron (FAFe) concentration at a single sampling site in Asahi River from 2022?2023 to explore the differences in the temporal scales. The objectives of this study were to evaluate the effects of physicochemical properties of the river on the concentration of FAFe, analyze the concentration of FAFe in spring, summer, autumn and winter, and assess the relationship between FAFe concentration and land use types of the watershed. The results indicated that physicochemical parameters, such as pH and surface water temperature (SWT) seemed to influence FAFe concentration (p < 0.05). Hydrological dynamics influenced FAFe concentration and transport, revealing an increasing trend during spring (p < 0.001) and summer (p = 0.05), with non-significant trends during autumn and winter (p > 0.05). FAFe exhibited a strong positive correlation with total organic carbon (TOC) (p < 0.001). Upland fields significantly influenced FAFe concentration (p < 0.01) through runoff with abundant NO3? and PO43? into the river. Thus, FAFe concentration in Asahi River was influenced by pH, SWT, TOC, hydrological regime, and agricultural runoff. en-copyright= kn-copyright= en-aut-name=YengehRohdof Lactem en-aut-sei=Yengeh en-aut-mei=Rohdof Lactem kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SomuraHiroaki en-aut-sei=Somura en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MoroizumiToshitsugu en-aut-sei=Moroizumi en-aut-mei=Toshitsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoriYasushi en-aut-sei=Mori en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MaedaMorihiro en-aut-sei=Maeda en-aut-mei=Morihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= en-keyword=dissolved iron kn-keyword=dissolved iron en-keyword=seasonal variation kn-keyword=seasonal variation en-keyword=dissolved organic matter kn-keyword=dissolved organic matter en-keyword=fulvic acid iron kn-keyword=fulvic acid iron END start-ver=1.4 cd-journal=joma no-vol=429 cd-vols= no-issue= article-no= start-page=529 end-page=565 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250605 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Polyhedral entire solutions in reaction-diffusion equations en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper studies polyhedral entire solutions to a bistable reaction-diffusion equation in Rn. We consider a pyramidal traveling front solution to the same equation in Rn+1. As the speed goes to infinity, its projection converges to an n-dimensional polyhedral entire solution. Conversely, as the time goes to -infinity, an n-dimensional polyhedral entire solution gives n-dimensional pyramidal traveling front solutions. The result in this paper suggests a correlation between traveling front solutions and entire solutions in general reaction-diffusion equations or systems. en-copyright= kn-copyright= en-aut-name=TaniguchiMasaharu en-aut-sei=Taniguchi en-aut-mei=Masaharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= en-keyword=Traveling front solution kn-keyword=Traveling front solution en-keyword=Entire solution kn-keyword=Entire solution en-keyword=Reaction-diffusion equation kn-keyword=Reaction-diffusion equation END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue=1 article-no= start-page=e70096 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250311 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Endoscopic ultrasonography-guided removal of a stent that had migrated into the pancreas post-pancreaticojejunostomy: A case report en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 64-year-old woman had undergone subtotal stomach-preserving pancreaticoduodenectomy for locally advanced pancreatic head cancer. She had an uneventful postoperative course with no recurrence. However, approximately 18 months after surgery, she presented with recurrent abdominal pain. Although contrast-enhanced computed tomography abdominal radiographs showed internal stent migration to the residual pancreas, dilatation of the tail side of the pancreatic duct was observed. The impaired internal stent was considered to be the cause of the abdominal pain. An attempt to remove the stent via balloon-assisted endoscopy was unsuccessful as the pancreaticojejunostomy site could not be reached. Consequently, endoscopic ultrasonography-guided pancreatic duct drainage was performed, and a plastic stent was placed through the jejunal site to the stomach. Two months later, the endosonographically/endoscopic ultrasonography-guided created route was dilated, and an endoscopic introducer was inserted into the pancreatic duct. Biopsy forceps were advanced through the sheath, allowing the successful removal of the stent by direct grasping. The symptoms of the patient improved, and she was discharged without complications. en-copyright= kn-copyright= en-aut-name=KajitaniSatoshi en-aut-sei=Kajitani en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsumotoKazuyuki en-aut-sei=Matsumoto en-aut-mei=Kazuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkiKentaro en-aut-sei=Oki en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MatsumiAkihiro en-aut-sei=Matsumi en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyamotoKazuya en-aut-sei=Miyamoto en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FujiiYuki en-aut-sei=Fujii en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=UchidaDaisuke en-aut-sei=Uchida en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TsutsumiKoichiro en-aut-sei=Tsutsumi en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HoriguchiShigeru en-aut-sei=Horiguchi en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OtsukaMotoyuki en-aut-sei=Otsuka en-aut-mei=Motoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Gastroenterology andHepatology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Gastroenterology andHepatology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Gastroenterology andHepatology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Gastroenterology andHepatology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Gastroenterology andHepatology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Gastroenterology andHepatology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Gastroenterology andHepatology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Gastroenterology andHepatology, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Gastroenterology andHepatology, Okayama University Hospital kn-affil= affil-num=10 en-affil=Department of Gastroenterology andHepatology, Okayama University Hospital kn-affil= en-keyword=endoscopic introducer kn-keyword=endoscopic introducer en-keyword=endoscopic ultrasonography-guided pancreatic duct drainage kn-keyword=endoscopic ultrasonography-guided pancreatic duct drainage en-keyword=endosonographically/EUS-guided created route kn-keyword=endosonographically/EUS-guided created route en-keyword=EUS-guided interventions kn-keyword=EUS-guided interventions en-keyword=internal stent kn-keyword=internal stent END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=5248 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Changes of leucine-rich alpha 2 glycoprotein could be a marker of changes of endoscopic and histologic activity of ulcerative colitis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Leucine-rich alpha 2 glycoprotein (LRG) is one of the serum biomarkers for disease activity of ulcerative colitis (UC). We focused on the correlation between the changes of LRG and the changes of endoscopic and histologic activity of UC, in comparison to the changes of fecal calprotectin (Fcal), fecal immunochemical test (FIT), and C-reactive protein (CRP). Seventy-nine patients with two or more colonoscopies were enrolled, and 123 paired colonoscopies and 121 paired biopsies were examined. With regard to the change of endoscopic/histologic activity between the preceding and subsequent colonoscopy, there was improvement (n = 29/45), unchanging (n = 63/36), and worsening (n = 31/40). The correlations between the changes of marker levels and endoscopic/histologic activity were Fcal; r = 0.50/0.39 and FIT; r = 0.41/0.40, LRG; r = 0.42/0.40 and CRP; r = 0.22/0.17. Furthermore, when the correlation between the changes of LRG levels and the changes of endoscopic/histological activity was compared with those of other markers, the correlation of LRG tended to be superior to those of CRP (CRP vs. LRG; p = 0.08/0.01). LRG is equivalent to fecal markers and superior to CRP, when inferring changes in disease activity of UC based on changes in its level. en-copyright= kn-copyright= en-aut-name=AoyamaYuki en-aut-sei=Aoyama en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HiraokaSakiko en-aut-sei=Hiraoka en-aut-mei=Sakiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YasutomiEriko en-aut-sei=Yasutomi en-aut-mei=Eriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=InokuchiToshihiro en-aut-sei=Inokuchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakeiKensuke en-aut-sei=Takei en-aut-mei=Kensuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IgawaShoko en-aut-sei=Igawa en-aut-mei=Shoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakeuchiKeiko en-aut-sei=Takeuchi en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TakaharaMasahiro en-aut-sei=Takahara en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=ToyosawaJunki en-aut-sei=Toyosawa en-aut-mei=Junki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YamasakiYasushi en-aut-sei=Yamasaki en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=KinugasaHideaki en-aut-sei=Kinugasa en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KatoJun en-aut-sei=Kato en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=OtsukaMotoyuki en-aut-sei=Otsuka en-aut-mei=Motoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Pathology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=13 en-affil=Department of Gastroenterology, Graduate School of Medicine, Chiba University kn-affil= affil-num=14 en-affil=Department of Gastroenterology, Japanese Red Cross Society Himeji Hospital kn-affil= affil-num=15 en-affil=Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Ulcerative colitis kn-keyword=Ulcerative colitis en-keyword=Leucine-rich alpha 2 glycoprotein kn-keyword=Leucine-rich alpha 2 glycoprotein en-keyword=Biomarker kn-keyword=Biomarker END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue= article-no= start-page=1543543 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Empowering pediatric, adolescent, and young adult patients with cancer utilizing generative AI chatbots to reduce psychological burden and enhance treatment engagement: a pilot study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Pediatric and adolescent/young adult (AYA) cancer patients face profound psychological challenges, exacerbated by limited access to continuous mental health support. While conventional therapeutic interventions often follow structured protocols, the potential of generative artificial intelligence (AI) chatbots to provide continuous conversational support remains unexplored. This study evaluates the feasibility and impact of AI chatbots in alleviating psychological distress and enhancing treatment engagement in this vulnerable population.
Methods: Two age-appropriate AI chatbots, leveraging GPT-4, were developed to provide natural, empathetic conversations without structured therapeutic protocols. Five pediatric and AYA cancer patients participated in a two-week intervention, engaging with the chatbots via a messaging platform. Pre- and post-intervention anxiety and stress levels were self-reported, and usage patterns were analyzed to assess the chatbots' effectiveness.
Results: Four out of five participants reported significant reductions in anxiety and stress levels post-intervention. Participants engaged with the chatbot every 2-3 days, with sessions lasting approximately 10 min. All participants noted improved treatment motivation, with 80% disclosing personal concerns to the chatbot they had not shared with healthcare providers. The 24/7 availability particularly benefited patients experiencing nighttime anxiety.
Conclusions: This pilot study demonstrates the potential of generative AI chatbots to complement traditional mental health services by addressing unmet psychological needs in pediatric and AYA cancer patients. The findings suggest these tools can serve as accessible, continuous support systems. Further large-scale studies are warranted to validate these promising results. en-copyright= kn-copyright= en-aut-name=HaseiJoe en-aut-sei=Hasei en-aut-mei=Joe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HanzawaMana en-aut-sei=Hanzawa en-aut-mei=Mana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NaganoAkihito en-aut-sei=Nagano en-aut-mei=Akihito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MaedaNaoko en-aut-sei=Maeda en-aut-mei=Naoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YoshidaShinichirou en-aut-sei=Yoshida en-aut-mei=Shinichirou kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=EndoMakoto en-aut-sei=Endo en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YokoyamaNobuhiko en-aut-sei=Yokoyama en-aut-mei=Nobuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OchiMotoharu en-aut-sei=Ochi en-aut-mei=Motoharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=IshidaHisashi en-aut-sei=Ishida en-aut-mei=Hisashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KatayamaHideki en-aut-sei=Katayama en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=FujiwaraTomohiro en-aut-sei=Fujiwara en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NakataEiji en-aut-sei=Nakata en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=NakaharaRyuichi en-aut-sei=Nakahara en-aut-mei=Ryuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KunisadaToshiyuki en-aut-sei=Kunisada en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=TsukaharaHirokazu en-aut-sei=Tsukahara en-aut-mei=Hirokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= affil-num=1 en-affil=Department of Medical Information and Assistive Technology Development, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Orthopedic Surgery, Gifu University Graduate School of Medicine kn-affil= affil-num=4 en-affil=Department of Pediatrics, NHO National Hospital Organization Nagoya Medical Center kn-affil= affil-num=5 en-affil=Department of Orthopedic Surgery, Tohoku University Graduate School of Medicine kn-affil= affil-num=6 en-affil=Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University kn-affil= affil-num=7 en-affil=Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University kn-affil= affil-num=8 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=10 en-affil=Department of Palliative and Supportive Care, Okayama University Hospital kn-affil= affil-num=11 en-affil=Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=13 en-affil=Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=14 en-affil=Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=15 en-affil=Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=16 en-affil=Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=generative AI chatbot kn-keyword=generative AI chatbot en-keyword=large language model kn-keyword=large language model en-keyword=pediatric cancer kn-keyword=pediatric cancer en-keyword=adolescent and young adult (AYA) kn-keyword=adolescent and young adult (AYA) en-keyword=psychological support kn-keyword=psychological support END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue= article-no= start-page=85 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Personal Networks and Social Support in Relation to Age of Elderly Women kn-title=‚—î—«‚̃p[ƒ\ƒiƒ‹Eƒlƒbƒgƒ[ƒN‚ƃ\[ƒVƒƒƒ‹EƒTƒ|[ƒg‚Ì”N—î‚É‚æ‚éˆá‚¢‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract=@’n•û¬“sŽs‚Å‚ ‚鉪ŽRŒ§‚—ÀŽs‚Å1997”N‚©‚ç1998”N‚É‚©‚¯‚Ä‚—î—«‚ð‘ÎÛ‚É’²¸‚ð‚¨‚±‚È‚Á‚½B–{e‚Å‚Í‚»‚̃f[ƒ^‚ð•ªÍ‚µC”N—î‚É‚æ‚Á‚Ä‚—î—«‚̃p[ƒ\ƒiƒ‹Eƒlƒbƒgƒ[ƒN‚ƃ\[ƒVƒƒƒ‹EƒTƒ|[ƒg‚Ì“üŽè‚ª‚ǂ̂悤‚É‘Šˆá‚·‚é‚©‚ðŒŸ“¢‚µ‚½B en-copyright= kn-copyright= en-aut-name=NOBEMasao en-aut-sei=NOBE en-aut-mei=Masao kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Social Studies Education, Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆçŠw•”ŽÐ‰ï‰È‹³ˆçuÀ en-keyword=‚—î—« kn-keyword=‚—î—« en-keyword=ƒp[ƒ\ƒiƒ‹Eƒlƒbƒgƒ[ƒN kn-keyword=ƒp[ƒ\ƒiƒ‹Eƒlƒbƒgƒ[ƒN en-keyword=ƒ\[ƒVƒƒƒ‹EƒTƒ|[ƒg kn-keyword=ƒ\[ƒVƒƒƒ‹EƒTƒ|[ƒg en-keyword=’n•û¬“sŽs kn-keyword=’n•û¬“sŽs END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue= article-no= start-page=45 end-page=53 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050715 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Daily Life and Life History of Elderly Women in Melbourne kn-title=ƒƒ‹ƒ{ƒ‹ƒ“‚ÉZ‚Þ‚—î—«‚Ì•é‚炵‚ƃ‰ƒCƒtEƒqƒXƒgƒŠ[ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@ƒƒ‹ƒ{ƒ‹ƒ“‚ÉZ‚Þ3l‚Ì‚—î—«‚ÉC‡@“úí¶ŠˆC‡A‰½‚ÉK•Ÿ‚ðŠ´‚¶‚é‚©C‡B‚±‚ê‚Ü‚Å‚Ìl¶‚Ì3“_‚ÉŠÖ‚µ‚Ä•·‚«Žæ‚è’²¸‚ð2004”N9ŒŽ‚É‚¨‚±‚È‚Á‚½B–{e‚Å‚Í•·‚«Žæ‚è’²¸‚ÌŒ‹‰Ê‚ð’ñŽ¦‚µC‚»‚ê‚ÉlŽ@‚ð‰Á‚¦‚½BlŽ@‚É‚æ‚Á‚ÄCŽŸ‚Ì4“_‚𖾂炩‚É‚µ‚½B‡@Žq‚Ç‚ài•v•wj‚Æ•p”É‚ÉŒðÛ‚Å‚«‚È‚¢‚—î—«‚ÍC‘ã‚í‚è‚ÉC—Fl‚Æ•p”É‚ÉŒðÛ‚ð‚µ‚Ä‚¢‚½B‚»‚±‚ÅCŽÐ‰ïŠÖŒW‚É‚Í‘ã‘Ö«‚ª‚ ‚é‚Æ‚¢‚¦‚éB‡A 3l‚Ì‚—î—«‚Í‚‚¢ŽåŠÏ“IK•ŸŠ´‚ðŽ‚Á‚Ä‚¢‚½B‚±‚ê‚ÍC‚—î—«‚ªŒ’N‚ÅC–L•x‚ȎЉïŠÖŒW‚ð•ÛŽ‚µ‚Ä‚¢‚½‚©‚ç‚Æl‚¦‚ç‚ê‚éB‡B‘å‹°Q‚ÍCƒI[ƒXƒgƒ‰ƒŠƒAl‚̉Ƒ°‚̶Šˆ‚É‘å‚Ȃ謂Ȃè‰e‹¿‚ð‹y‚Ú‚µ‚Ä‚¢‚½B‡C‘æ“ñŽŸ¢ŠE‘åí’¼ŒãCƒI[ƒXƒgƒ‰ƒŠƒA‚Å‚Íê‹ÆŽå•w‚ªˆê”Ê“I‚Å‚ ‚Á‚½B en-copyright= kn-copyright= en-aut-name=NOBEMasao en-aut-sei=NOBE en-aut-mei=Masao kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Social Studies Education, Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆçŠw•”ŽÐ‰ï‰È‹³ˆçuÀ en-keyword=‚—î—« kn-keyword=‚—î—« en-keyword=ƒƒ‹ƒ{ƒ‹ƒ“ kn-keyword=ƒƒ‹ƒ{ƒ‹ƒ“ en-keyword=ƒp[ƒ\ƒiƒ‹Eƒlƒbƒgƒ[ƒN kn-keyword=ƒp[ƒ\ƒiƒ‹Eƒlƒbƒgƒ[ƒN en-keyword=ŽåŠÏ“IK•ŸŠ´ kn-keyword=ŽåŠÏ“IK•ŸŠ´ en-keyword=ƒ‰ƒCƒtEƒqƒXƒgƒŠ[ kn-keyword=ƒ‰ƒCƒtEƒqƒXƒgƒŠ[ END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue=1 article-no= start-page=35 end-page=40 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Evaluation of CT Findings in Squamous and Non-Squamous Cell Carcinomas of the Maxillary Sinus en-subtitle= kn-subtitle= en-abstract= kn-abstract=The aim of the present study was to compare CT images between squamous cell carcinoma (SCC) and non-SCC found in the maxillary sinus, and to identify features that could be used to differentiate between SCC and non-SCC. Patients who visited the Faculty of Dentistry, Okayama University Hospital, between April 2007 and March 2023, underwent head and neck CT, and had tumors extending into the maxillary sinus that were diagnosed histopathologically as malignancy, were enrolled. The main seat of the mass, bony changes in the maxillary sinus wall, and extension into the surrounding area were assessed. These imaging features were evaluated according to SCC or non-SCC, and the characteristics of the two classes were assessed. Comparisons between the two groups were made using the Fisher exact probability test. There were 11 cases each of SCC and non-SCC. In 11 SCC and 7 non-SCC cases, the main seat of the mass occupied the entire maxillary sinus. The frequency of mass occupying the whole sinus was significantly higher in SCC than in non-SCC (p<0.05). Bone-thickening type disease was found only in squamous cell carcinoma 4/11 (36.4%), with there being a significant difference between SCC and non-SCC (p<0.05). Occupancy of the entire maxillary sinus by the mass and bone thickening on CT images were useful for differentiating between SCC and non-SCC arising in the maxillary sinus. en-copyright= kn-copyright= en-aut-name=AsaumiYuka en-aut-sei=Asaumi en-aut-mei=Yuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujikuraMamiko en-aut-sei=Fujikura en-aut-mei=Mamiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HisatomiMiki en-aut-sei=Hisatomi en-aut-mei=Miki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=E. Al-HammadWlla en-aut-sei=E. Al-Hammad en-aut-mei=Wlla kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakeshitaYohei en-aut-sei=Takeshita en-aut-mei=Yohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkadaShunsuke en-aut-sei=Okada en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KawazuToshiyuki en-aut-sei=Kawazu en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YanagiYoshinobu en-aut-sei=Yanagi en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=AsaumiJunichi en-aut-sei=Asaumi en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Oral and Maxillofacial Radiology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Oral and Maxillofacial Radiology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Oral and Maxillofacial Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Oral and Maxillofacial Radiology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Oral and Maxillofacial Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Dental Informatics, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= 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