検索結果 5995 件
| JaLCDOI | 10.18926/40187 |
|---|---|
| タイトル（別表記） | The positive rate of RA- test in various diseases, with supplementary study on the RA-test of synovial fluid |
| フルテキストURL | pitsr_037_021_030.pdf |
| 著者 | 江沢 英光| |
| 抄録 | Since the report of the agglutination test with Streptococcus by Cecil in 1931 there appeared many reports dealing with the serum reaction involved in rheumatoid arthritis. Among these the modified form of sensitized sheep blood cell agglutination test as proposed by WAALER (1940) and ROSE (1948) had been for a long time the only method applied to the diagnosis of rheumatoid arthritis. However, as this method had disadvantages of its complex manipulation and of being relatively sensitive, generally satisfactory results could not be obtained with it. Since then the latex agglutination test by PLATZ and SINGER (1957) was used in conjuction with the bentonite agglutination test by BOZIEVICH (1957). By the RA-test it means the test where agglutination is attained by the combined reaction of the human serum to be tested and the polystyrene latex granules bound to human gamma-globulin, and it is being widely used in daily clinical examinations. For the purpose to know the positive rate of this test in disesaes other than rheumatoid arthritis, we applied this test to the patients with various diseases both visiting our out-patient clinic and those hospitalized, and studied the results. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1967-12-15 |
| 巻 | 37巻 |
| 開始ページ | 21 |
| 終了ページ | 30 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002400928 |
| JaLCDOI | 10.18926/40143 |
|---|---|
| タイトル（別表記） | Rheumatoid arthritis and Sjögren's syndrome |
| フルテキストURL | 042_031_045.pdf |
| 著者 | 市川 幸延| |
| 抄録 | 1. Parotid Sialography Parotid sialograms were investigated in 29 patients with classical or definite RA according to the criteria of the American Rheumatism Association (one of whom had scleroderma), 5 patients with SLE (according to the Dubois's criteria, three were definite, one probable and another possible SLE), 3 patients with other autoimmune diseases (Hashimoto's thyroiditis, colitis ulcerosa and undiagnosed collagen disease), 3 patients with polyarthralgia and 10 patients with nonautoimmune diseases. Sialographic technique was performed by modified Rubin's Method using contrast medium Conray-400. Sialectasis which is pathognomonic of Sjögren's syndrome (SS) alone was observed in 6 patients with RA (20.7%) (3 punctate and 3 globular patterns) and 2 patients with SLE (one punctate and another globular pattern). Retention of the contrast medium in the duct for at least 5 minutes after the injection was observed in patients with RA, one patient with SLE and one patient with colitis ulcerosa. Sial ectasis and retention almost always existed together, and were observed in patients from young to older one. Although dilatation of the Stensen's duct and subalveolar dissection also existed together, they were observed in only older patients. It appeared that the former is the specific findings of SS and the latter is the non-specific findings according to the aging. Dry mouth was complained in 7 sialectasis (87.5%), 3 subalveolar dissection (60.0%), 10 retention (62.5%) and 9 normal sialogram (37.5%). Salivary hyposecretion (less than 10 ml/10min) was observed in 4 sialectasis (50%), one subalveolar dissection (20%), 6 dilatation of the Stensen's duct (37.5%), 5 retention (45.5%) and one normal sialogram (4.2%). These results show that sialectasis and retention are well correlated with salivary hyposecretion, but dry mouth is not so diagnostic in SS. Two patients with SLE had sialectasis were young women and showed normal salivary and lacrimal secretion. These cases may be supported by Heaton's hypothesis that SS is a benign and chronic form of SLE, or thay may be a subclinical state of SS. 2. Schirmer test Sixty seven patients (36RA, 6SLE, 3 other autoimmune diseases, 3 polyarthralgia and 19 non-autoimmune diseases) were examined by Schirmer test. Besides lacrimal hyposecretion was observed in RA and other autoimmune diseases, it began in younger age. These results show that autoimmune diseases have a sicca element in themselves. Compared with the results of sialography, Schirmer test was not correlated with sialectasis and retention. Dry eye was complained in only 4 patients (13.3%) with lacrimal hyposecretion (less than 10mm/5min) and all patients with dry eye had keratoconjunctivitis sicca (KCS). Dry eye is more diagnostic than Schirmer test. 3. Corneal staining by 1% rose bengal solution Twenty five patients with RA or SLE were examned corneal staining (Holm's type A) was observed in 5 patients with RA (20%). Staining of the medial and lateral bulbar conjunctiva (Holm's type B and C) were observed in 6 patients with RA (24%) and one patient with SLE. Nine patients with positive staining (type A, B and C) (75%) showed lacrimal hyposecretion. Dry eye was complained in 4 patients with type A staining (80%), but no patient with type B and C complained dry eye. Dry eye appears to be specific for the diagnosis of SS as sialectasis on the sialogram. 4. Salivary secretion All amount of saliva was collected during ten minutes chewing two pieces of gum. All of 21 patients with non-autoimmune diseases showed more than 10 ml/10min, and slight degree of salivary hyposecretion was observed with aging. Nine patients with RA (25.7%) showed salivary hyposecretion (less than 10ml/10min), besides it began in younger age. It was also observed in patients with other autoimmune diseases. Only 36.4% patients with salivary hyposecretion showed sialectasis on the sialogram. It can be supposed that patients with sialectasis and good salivary secretion are subclinical states of SS, and that this state is depends on the compensative function of the glands. Therefore, it is impossible to suppose the salivary dysfunction from the complaints of patients alone. It is required that saliva must be analysed not only quantitativly but also qualitativly (such as RA factor, complement and lysozome). Dry mouth was not only complained in 9 patients who showed salivary hyposecretion (81.8%). but in 10 patients showed normal secretion (50%). Dry mouth appears to be less specific for the diagnosis of SS than dry eye. 5. Diagnosis of SS Vanslow's criteria of SS was modified as follows. (1) Major : ① Sialectasis or salivary gland enlargement ② Positive corneal staining (type A) ③ Classical or definite RA (according to the criteria of the ARA) (2) Minor : ① Arthritis ② History ot salivary gland swelling ③ Dry mouth or salivary hyposecretion (less than 10ml/10min) ④ Dry eye or positive Schirmer test (less than 10mm/5min). Three major was diagnosed as definite, 2 major as probable and one major with one or more minor as possible SS. Of 35 patients with RA, definite (8.6%), probable (17.1%) and possible SS (54.3%) were obserevd. Two of SLE (33.3%) were possible SS. One patients with undiagnosed collagen disease was possible SS. Clinically, definite and probable SS may be diagnosed as Sjögren's syndrome. Two possible SS with SLE may be supporsed as subclinical states of SS who do not yet exhibite full criteria. Compared with the clinical and laboratory findings of these definite, probable and possible SS with RA, it was supporsed that positive antinuclear factor or positive LE cells in RA patients almost always represents SS, drug allergy, especially to gold therapy may be a manifestation of SS. Hypergammaglobulinemia, extreme elevation of erythrocyte sedimentation rate, struma, lymphnode enlargement in RA patients must be suspected of SS. Although one possible SS with SLE and one probable SS with RA showed positive ANF (peripheral pattern), it is impossible to differentiate SS from SLE by ANF alone. Because Suzuki et al. reported that 15.4% of SS had showed positive ANF (peripheral pattern). Examinations of salivary glands including sialography must be performed in patients with SLE in the future. To detect a subclinical SS, sialography and corneal staining must be performed even in patients with no sicca symptom, because of the compensatory functions of salivary and lacrimal glands. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1973-03-25 |
| 巻 | 42巻 |
| 開始ページ | 31 |
| 終了ページ | 45 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532309 |
| JaLCDOI | 10.18926/40142 |
|---|---|
| タイトル（別表記） | A case of systemic lupus erythematosus with idiopathic thrombocytopenic purpura |
| フルテキストURL | pitsr_042_025_029.pdf |
| 著者 | 市川 幸延| 池上 忠興| 北山 稔| 森永 寛| |
| 抄録 | A 24-year-old woman was presented in whom thrombocytopenic purpura appeared during antiinflammatory drugs therapy for arthralgia. At that time she had a positive LE cell preparation, positive antinuclear factor and false positive serum test for syphilis. Steroid hormon and ACTH therapy were started under the diagnosis of systemic lupus erythematosus. In the 23-rd hospital days, she had a negative LE cell preparation, negative antinuclear factor and negative serum test for syphilis. In the 28-th days after stopping steroid hormon and ACTH therapy, positive LE cell preparation and positive antinuclear factor appeared again. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1973-03-25 |
| 巻 | 42巻 |
| 開始ページ | 25 |
| 終了ページ | 29 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002398146 |
| JaLCDOI | 10.18926/40136 |
|---|---|
| タイトル（別表記） | Oxygen Isotopic Composition of Water in the Living Things : Preliminary Analyses and Discussions |
| フルテキストURL | pitsr_044_061_075.pdf |
| 著者 | 木島 宣明| |
| 抄録 | Oxygen isotope analysis was carried out, by use of a new method (oxalate equilibration method) of preparing CO(2) for mass spectrometry, on water samples extracted from a number of biological samples collected in Misasa Town and Hashizu Coast, Tottori Prefecture. The δ values (the per mil enrichment of (18)O in sample waters relative to the Standard Mean Ocean Water) were suggested to be distributed in the living things as follows. The water absorbed by plant roots was supposed to have the same δ value with the water outside it (δs. about -8‰), and in a rapidly transpiring plant, this water reached the leaves, partly infiltrating into the phloem. When transpiration was slow, on the other hand, the isotopic composition of ascending xylem sap was modified by the exchange of water with phloem. where leaf water with a higher δ value was migrating. As Gonfiantini et aI. (1965) and Dongmann et al. (1972) have odserved, leaf waters were enriched markedly in (18)O in the daytime. A criterion of the δ of leaf water may be the sum of δs and △δ that corresponds to the (18)O fractionation factor in the H(2)O(I)-H(2)O(v) system. The sum comes to about 0‰ at ordinary leaf temperatures. and really δ values near 0‰ were observed in leaves of some herbaceous plants, in exudate from a tip of vine of Kudzu, in body fluid of herbivorous insects, etc., but higher δs (up to +19‰) were also observed in some other leaves such as pine needles, Especially leaves showed an increase in δ by about 10 ‰ toward the pnd of November when the average temperature fell below 10℃, probably because of accumulation of the daily enrichment as a resul t of slow water absorption and circulation. A few plant species grown on a dune were analyzed and it seemed that, among them, herbaceous plants were dependent on spraied sea water and pine trees on ground water. δ's of petal water were dispersed (-9～-3‰), probably according to the volume-to-transpirational flux ratio of water in the petals. Succurent fruits in enlarging stage seemed to have lower δ's near δs, but in maturing stagp δ's increaspd to about -4‰, i.e., to the avpraged δ of Ieaf water in the day and night. Herbivorous insects (imagines and la rvae) in general had distinctly higher δ values than carnivorous insects, the border being at -1‰. However, lower δ's at about -5‰ were obserbed on aphides which might have been sucking somewhat dilutpd leaf water from seave tube cells. Sometimes the δ of a herbivorous insect was a few per mil higher than that of the leaf it was nibbling, probably as a result of evaporation of water from the insect and of respiration. The level at about -3‰ common for carnivorous insects could not be explained, although tipula and chironomus making a swarm also showed a δ value on the level. Blood of a heron did not show such a low δ as supposed from its food habit. As compared with the drinking water of -8‰, blood and urine were found to have an identical δ in the range of -4 to -5‰ in either mouse or man, The δ value of the oxidation water produced in man's body was estimated to be about -6‰ from an approximate water balance. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1975-03-25 |
| 巻 | 44巻 |
| 開始ページ | 61 |
| 終了ページ | 75 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002383784 |
| JaLCDOI | 10.18926/AMO/40135 |
|---|---|
| フルテキストURL | 64_4_263.pdf |
| 著者 | Pavelić, Jasminka| Čulić, Srdjana| Čulić, Vida| |
| 抄録 | The occurrence of Langerhans cell histiocytosis (LCH) and another malignancy in the same patient is infrequent but has been recognized. The genetic changes that could be responsible for LCH and/or concomitant leukemia development are obscure. To the best of our knowledge, this is the first description of constitutional maternally derived inv (9) (p12;q13) in an LCH patient, and also of the development of common ALL Ph after LCH diagnosis and therapy. The potential significance of these findings [inv (9)LCHALL Ph] and their mutual relationship are unknown. Therefore, cooperative studies of large numbers of patients are needed to identify the common risk factors, if any. |
| キーワード | acute lymphoblastic leukemia genetic changes langerhans cell histiocytosis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-08 |
| 巻 | 64巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 263 |
| 終了ページ | 265 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20802544 |
| Web of Science KeyUT | 000281384400008 |
| JaLCDOI | 10.18926/AMO/40129 |
|---|---|
| フルテキストURL | 64_4_219.pdf |
| 著者 | Doi, Maho| Miyazaki, Ikuko| Nagamachi, Tomoko| Shinomiya, Kazuaki| Matsunaga, Hisashi| Sendo, Toshiaki| Kawasaki, Hiromu| Asanuma, Masato| Gomita, Yutaka| Kitamura, Yoshihisa| |
| 抄録 | We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH. |
| キーワード | ACTH imipramine lithium proliferation Ki-67 |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-08 |
| 巻 | 64巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 219 |
| 終了ページ | 223 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20802538 |
| Web of Science KeyUT | 000281384400002 |
| JaLCDOI | 10.18926/AMO/40128 |
|---|---|
| フルテキストURL | 64_4_213.pdf |
| 著者 | Otani, Hiroyuki| Otsuka, Fumio| Inagaki, Kenichi| Suzuki, Jiro| Makino, Hirofumi| |
| 抄録 | Aldosterone production occurs in the adrenal cortex, and is regulated primarily by angiotensin II (Ang II), potassium and adrenocorticotropin (ACTH). In the presence of the aldosterone stimulators, steroidogenesis is further governed by local autocrine and/or paracrine factors in the adrenal cortex. We reported the presence of functional bone morphogenetic protein (BMP) system in the adrenal cortex and also demonstrated that BMP-6 increases Ang II-induced aldosterone production, which could be involved in the "aldosterone breakthrough" phenomenon. Aldosterone breakthrough is the phenomenon by which circulating aldosterone concentrations increase above pre-treatment levels after long-term therapy with ACE inhibitors or Ang II type 1 receptor antagonists (ARB). This phenomenon may lead to important clinical consequences since increased aldosterone in a high-salt state facilitates cardiovascular and renal damage in hypertensive patients. We found that long-term ARB treatment reverses the reduction of aldosterone synthesis by adrenocortical cells, thereby causing "cellular aldosterone breakthrough". The availability of BMP-6 in the adrenal cortex may be at least partly involved in the occurrence of cellular escape from aldosterone suppression under chronic treatment with ARB. |
| キーワード | adrenal cortex angiotensin II aldosterone bone morphogenetic protein |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-08 |
| 巻 | 64巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 213 |
| 終了ページ | 218 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20802537 |
| Web of Science KeyUT | 000281384400001 |
| 著者 | 細川 忍| |
|---|---|
| 発行日 | 2010-06-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 菊本 陽子| |
|---|---|
| 発行日 | 2010-06-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 大塚 淳| |
|---|---|
| 発行日 | 2010-06-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 高畑 浩之| |
|---|---|
| 発行日 | 2010-06-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 末光 俊介| |
|---|---|
| 発行日 | 2010-06-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 永坂 岳司| 田中 紀章| 孫 冬生| 猶本 良夫| 松原 長秀| 八木 孝仁| 藤原 俊義| |
|---|---|
| 発行日 | 2010-08-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 内富 庸介| |
|---|---|
| 発行日 | 2010-08-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 田邊 賢司| 竹居 孝二| |
|---|---|
| 発行日 | 2010-08-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 古松 毅之| 尾﨑 敏文| 浅原 弘嗣| |
|---|---|
| 発行日 | 2010-08-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/40008 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Hirai, Kazuyuki| Arimitsu, Hideyuki| Umeda, Koji| Yokota, Kenji| Shen, Lianhua| Ayada, Kiyoshi| Kodama, Yoshikatsu| Tsuji, Takao| Hirai, Yoshikazu| Oguma, Keiji| |
| 抄録 | In an attempt to prepare egg yolk immunoglobulin (IgY) to treat and prevent cholera, hens were immunized by a mixture of heat- or formalin-killed Vibrio cholerae O1 and O139 organisms, or by the recombinant cholera toxin B subunit (CTB). The IgYs were partially purified from egg yolk and orally administered to suckling mice before or after challenge with live O1 or O139 cells. The anti-O1 and O139 IgYs and the mixture of either IgY with anti-CTB IgY significantly protected the occurrence of cholera caused by both O1 and O139 infection. Since large amounts of IgY can be prepared very easily and at low cost, this seems to be a useful procedure for preventing and treating cholera. |
| キーワード | Vibrio cholerae O1 O139 IgY |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-06 |
| 巻 | 64巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 163 |
| 終了ページ | 170 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20596127 |
| Web of Science KeyUT | 000279094300002 |
| 著者 | Kimura, Yoshinobu| Sakamura, Sho| Ushijima, Takayuki| Hama, Yoichiro| Kajiura, Hiroyuki| Fujiyama, Kazuhito| Okihara, Kiyoshi| Hashimoto, Ken| Sugimoto, Hiroyuki| Yamada, Hideo| |
|---|---|
| 発行日 | 2007-04 |
| 出版物タイトル | Bioscience, Biotechnology, and Biochemistry |
| 巻 | 71巻 |
| 号 | 4号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Sawada, Keisuke| Echigo, Noriko| Juge, Narinobu| Miyaji, Takaaki| Otsuka, Masato| Omote, Hiroshi| Yamamoto, Akitsugu| Moriyama, Yoshinori| |
|---|---|
| 発行日 | 2008-04-01 |
| 出版物タイトル | Proceedings of the National Academy of Sciences of the United States of America |
| 巻 | 105巻 |
| 号 | 15号 |
| 資料タイプ | 学術雑誌論文 |
| フルテキストURL | Fulltext.pdf fig.pdf table.pdf |
|---|---|
| 著者 | Matsumoto, Yohsuke| Motoki, Takahiro| Kubota, Satoshi| Takigawa, Masaharu| Tsubouchi, Hirohito| Gohda, Eiichi| |
| キーワード | hepatocyte growth factor valproic acid histone deacetylase inhibitor butyric acid trichostatin A induction tumor invasion dermal fibroblast |
| 備考 | Published with permission from the copyright holder. This is a author's copy,as published in Biochemical and Biophysical Research Communications, 2008 Vol.366 Issue.1 pp.110-116 | |
| 発行日 | 2008-02-01 |
| 出版物タイトル | Biochemical and Biophysical Research Communications |
| 巻 | 366巻 |
| 号 | 1号 |
| 出版者 | Academic Press |
| 開始ページ | 110 |
| 終了ページ | 116 |
| ISSN | 0006-291X |
| NCID | AA00564395 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 18053801 |
| DOI | 10.1016/j.bbrc.2007.11.089 |
| Web of Science KeyUT | 000252392400018 |