start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=1
article-no=
start-page=e70055
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250107
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Short‐process incudo‐stapedioplasty in congenital ear malformation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objectives: Although various stapedotomy and stapedectomy techniques exist, anchoring the piston can be challenging. We present a novel surgical approach for treating congenital stapes malformations with an atypical facial nerve trajectory.<br>
Methods: This is a case of a 7-year-old boy presenting with bilateral conductive hearing loss. Prior attempts at tympanoplasty had proven unsuccessful in improving his hearing. Presurgical imaging studies revealed an unusual anatomical configuration, with the facial nerve positioned inferior to the oval window. This anatomical variation precluded the use of conventional prosthesis-anchoring techniques typically employed in stapedotomies. Thus, we devised an innovative approach, opting to anchor the prosthesis to the short process of the incus.<br>
Results: This novel technique circumvented the atypical course of the facial nerve, allowing for successful reconstruction of the ossicular chain. The patient demonstrated an acceptable improvement (30?dB gain) in hearing 1-year post-surgery, with no reported complications.<br>
Conclusion: This case underscores the critical importance of adapting surgical techniques to address the unique anatomical challenges that may arise in the context of congenital ear malformations. It also highlights the potential of the short process of the incus as a viable alternative anchoring site for stapes prostheses, thereby improving the outcomes of such complex cases. This technique not only restored the patient's hearing but also contributed valuable insights into the management of similar cases, potentially improving the quality of life for individuals with rare and challenging anatomical variations.<br>
Level of evidence: 5.
en-copyright=
kn-copyright=

en-aut-name=OmichiRyotaro
en-aut-sei=Omichi
en-aut-mei=Ryotaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KariyaShin
en-aut-sei=Kariya
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SugayaAkiko
en-aut-sei=Sugaya
en-aut-mei=Akiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AndoMizuo
en-aut-sei=Ando
en-aut-mei=Mizuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Otolaryngology-Head and Neck Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Otolaryngology-Head and Neck Surgery, Kawasaki Medical School
kn-affil=

affil-num=3
en-affil=Department of Otolaryngology-Head and Neck Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=4
en-affil=Department of Otolaryngology-Head and Neck Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=
en-keyword=congenital ear malformation
kn-keyword=congenital ear malformation
en-keyword=incus
kn-keyword=incus
en-keyword=prosthesis
kn-keyword=prosthesis
en-keyword=stapedectomy
kn-keyword=stapedectomy
en-keyword=stapedotomy
kn-keyword=stapedotomy
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=3
article-no=
start-page=337
end-page=345
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Study on the Grinding Temperature of Workpiece in Side Plunge Grinding Process
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Grinding is used to finish thrust metal attachment parts, such as crankshafts, which have both journal and thrust surfaces. In side plunge grinding, a thrust surface and a cylindrical surface of a shaft workpiece with collars are finished in a single plunge grinding process. However, the surface quality near the ground internal corner, where grinding fluid may not penetrate, can deteriorate, causing high residual stress and cracks owing to grinding heat. While it has been reported that quality issues at the inner corners of the ground surface can be mitigated by reducing the grinding point temperature through efficient cooling fluid supply, the mechanisms of grinding phenomena and heat generation in side plunge grinding are not yet fully understood. In this study, the variations in the grinding temperature at the thrust surface of a workpiece with a collar were experimentally investigated using a wire/workpiece thermocouple to clarify these phenomena. The results revealed a significant increase in the grinding temperature at the corners of the grinding zone. However, it slightly decreases as the thermocouple output approaches the center of the workpiece, indicating a slight effect of the grinding speed. The surface temperature of the workpiece in side plunge grinding is primarily influenced by the wheel depth-of-cut in the thrust direction. Additionally, the effect of workpiece rotational speed and grinding infeed speed on temperature distribution has been demonstrated.
en-copyright=
kn-copyright=

en-aut-name=GaoLingxiao
en-aut-sei=Gao
en-aut-mei=Lingxiao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KuidaMotoki
en-aut-sei=Kuida
en-aut-mei=Motoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KodamaHiroyuki
en-aut-sei=Kodama
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OhashiKazuhito
en-aut-sei=Ohashi
en-aut-mei=Kazuhito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=
en-keyword=grinding
kn-keyword=grinding
en-keyword=thrust surface
kn-keyword=thrust surface
en-keyword=grinding temperature
kn-keyword=grinding temperature
en-keyword=thermocouple
kn-keyword=thermocouple
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=21
article-no=
start-page=13372
end-page=13380
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250520
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Unraveling the Molecular Mechanism of Transient Multilamellar Formation in Ethanol-Modified Vesicle Solutions
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A recent microfluidic-based small-angle X-ray scattering (SAXS) measurement intriguingly suggested the transient formation of multilamellar structures during the mixing of unilamellar vesicles with ethanol in an aqueous solution. This study explores a possible molecular mechanism underlying this phenomenon, primarily through coarse-grained molecular dynamics (CG-MD) simulations. We first examined lipid aggregate morphology as a function of ethanol concentration in an aqueous solution. Even though vesicles were observed in pure aqueous solution, increasing ethanol concentrations led to more frequent pore formation in vesicular membranes. At ethanol concentrations above 52%, vesicles destabilized and transformed into worm-like micelles. We hypothesized that the transient multilamellar structures might arise from vesicle stacking due to variations in the effective interactions between vesicles. However, a series of potential of mean force (PMF) calculations consistently showed repulsive interactions between vesicles, regardless of ethanol concentration, ruling out this possibility. In contrast, once lipid aggregates transformed into worm-like micelles, the PMF barrier between them dropped (?5kBT), promoting fusion. Our CG-MD simulations further demonstrated that lipid aggregates (micelles) readily fused and grew in high ethanol concentrations. Upon subsequent exposure to lower ethanol levels, these enlarged aggregates reorganized into vesicles with internal lamellar structure─multilamellar vesicles. These findings suggest that the heterogeneous mixing of unilamellar vesicular solutions with ethanol in a microfluidic device plays a key role in the emergence of transient multilamellar structures.
en-copyright=
kn-copyright=

en-aut-name=ShibataKana
en-aut-sei=Shibata
en-aut-mei=Kana
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MaekiMasatoshi
en-aut-sei=Maeki
en-aut-mei=Masatoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TokeshiManabu
en-aut-sei=Tokeshi
en-aut-mei=Manabu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ShinodaWataru
en-aut-sei=Shinoda
en-aut-mei=Wataru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Materials Chemistry, Nagoya University
kn-affil=

affil-num=2
en-affil=Division of Applied Chemistry, Faculty of Engineering, Hokkaido University
kn-affil=

affil-num=3
en-affil=Division of Applied Chemistry, Faculty of Engineering, Hokkaido University
kn-affil=

affil-num=4
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=1
article-no=
start-page=32
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250512
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Stability and water solubility of calcium ferrite-type aluminum-rich phase: implications for deep water cycle caused by subducting basaltic crusts
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The subducting crustal materials serve as a crucial channel for transporting water to the lower mantle. Recent experimental studies suggest that crustal materials such as basaltic crust can be a main water carrier and reservoir playing an important role on water cycling in the lower mantle. Despite being a primary mineral in crustal materials, the water solubility of calcium ferrite-type (CF) phase and its stability are unclear yet. A recent phase relation study of hydrous basalts showed Na-depletion in lower-mantle minerals, suggesting the presence of fluid possibly with high Na concentration and the absence of CF phase along the low-temperature slab geotherms, where Al-rich hydrous phase H and ferropericlase appear instead. These phases could consequently produce Na-depleted CF phase when reaching the dehydration temperature of Al-rich hydrous phase H. In this study, we investigated the stability and water solubility of CF-type MgAl2O4, which is a main CF component in a hydrous basalt, in water-bearing systems at 26?32 GPa and 1200?1900 °C using a Kawai-type multi-anvil press. Our results indicate that the stability of the CF phase is strongly influenced by water content in the system. Water contents of recovered CF phases estimated by Fourier-transform infrared spectroscopy show a limited variation between 73 and 87 ppm wt at a pressure of 26 GPa and temperatures of 1500?1900 °C. We suggest that CF phase could not be a primary water carrier at lower mantle depths. This emphasizes contributions of hydrous aluminous silica minerals to Earth’s deep water cycling and heterogeneous structures in the lower mantle due to the strong water partitioning to this phase compared with other constituent minerals.
en-copyright=
kn-copyright=

en-aut-name=ZhangXinyue
en-aut-sei=Zhang
en-aut-mei=Xinyue
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MashinoIzumi
en-aut-sei=Mashino
en-aut-mei=Izumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IshiiTakayuki
en-aut-sei=Ishii
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Deep Space Exploration Laboratory/School of Earth and Space Sciences, University of Science and Technology of China
kn-affil=

affil-num=2
en-affil=Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=3
en-affil=Institute for Planetary Materials, Okayama University
kn-affil=
en-keyword=Water solubility
kn-keyword=Water solubility
en-keyword=CF phase
kn-keyword=CF phase
en-keyword=Single crystal
kn-keyword=Single crystal
en-keyword=FTIR
kn-keyword=FTIR
en-keyword=MORB
kn-keyword=MORB
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=1
article-no=
start-page=5
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=In-frame deletion variant of ABCD1 in a sporadic case of adrenoleukodystrophy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Adrenoleukodystrophy (ALD), an X-linked leukodystrophy caused by pathogenic variants in ABCD1, exhibits a broad range of phenotypes from childhood-onset cerebral forms to adult-onset adrenomyeloneuropathy (AMN). We report a rare in-frame ABCD1 deletion c.1469_71delTGG (p.Val490del) in a man with AMN. Although this variant has been interpreted as ‘uncertain significance’ in ClinVar, biochemical analysis along with clinical evaluation confirmed the pathogenicity of this variant, underscoring the importance of functional assessment of in-frame deletions.
en-copyright=
kn-copyright=

en-aut-name=MatsukawaTakashi
en-aut-sei=Matsukawa
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SudoAtsushi
en-aut-sei=Sudo
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KakumotoToshiyuki
en-aut-sei=Kakumoto
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HaoAkihito
en-aut-sei=Hao
en-aut-mei=Akihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KainagaMitsuhiro
en-aut-sei=Kainaga
en-aut-mei=Mitsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ChangHyangri
en-aut-sei=Chang
en-aut-mei=Hyangri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ManoTatsuo
en-aut-sei=Mano
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IshiuraHiroyuki
en-aut-sei=Ishiura
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MitsuiJun
en-aut-sei=Mitsui
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=HayashiToshihiro
en-aut-sei=Hayashi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=MorishitaShinichi
en-aut-sei=Morishita
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=TsujiShoji
en-aut-sei=Tsuji
en-aut-mei=Shoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=TodaTatsushi
en-aut-sei=Toda
en-aut-mei=Tatsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=2
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=3
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=4
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=5
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=6
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=7
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=8
en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Precision Medicine Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=10
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=11
en-affil=Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
kn-affil=

affil-num=12
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=13
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=3
article-no=
start-page=976
end-page=991
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202506
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Enhanced estimation method for partial scattering functions in contrast variation small-angle neutron scattering via Gaussian process regression with prior knowledge of smoothness
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Contrast variation small-angle neutron scattering (CV-SANS) is a powerful tool for evaluating the structure of multi-component systems. In CV-SANS, the scattering intensities I(Q) measured with different scattering contrasts are de?com?posed into partial scattering functions S(Q) of the self- and cross-correlations between components. Since the measurement has a measurement error, S(Q) must be estimated statistically from I(Q). If no prior knowledge about S(Q) is available, the least-squares method is best, and this is the most popular estimation method. However, if prior knowledge is available, the estimation can be improved using Bayesian inference in a statistically authorized way. In this paper, we propose a novel method to improve the estimation of S(Q), based on Gaussian process regression using prior knowledge about the smoothness and flatness of S(Q). We demonstrate the method using synthetic core?shell and experimental polyrotaxane SANS data.
en-copyright=
kn-copyright=

en-aut-name=ObayashiIppei
en-aut-sei=Obayashi
en-aut-mei=Ippei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MiyajimaShinya
en-aut-sei=Miyajima
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TanakaKazuaki
en-aut-sei=Tanaka
en-aut-mei=Kazuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MayumiKoichi
en-aut-sei=Mayumi
en-aut-mei=Koichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Center for Artificial Intelligence and Mathematical Data Science, Okayama University
kn-affil=

affil-num=2
en-affil=Faculty of Science and Engineering, Iwate University
kn-affil=

affil-num=3
en-affil=Global Center for Science and Engineering, Waseda University
kn-affil=

affil-num=4
en-affil=Institute for Solid State Physics, University of Tokyo
kn-affil=
en-keyword=contrast variation small-angle neutron scattering
kn-keyword=contrast variation small-angle neutron scattering
en-keyword=CV-SANS
kn-keyword=CV-SANS
en-keyword=partial scattering functions
kn-keyword=partial scattering functions
en-keyword=multi-component systems
kn-keyword=multi-component systems
en-keyword=statistical methods
kn-keyword=statistical methods
en-keyword=Bayesian inference
kn-keyword=Bayesian inference
en-keyword=contrast variation
kn-keyword=contrast variation
en-keyword=Gaussian process regression
kn-keyword=Gaussian process regression
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250609
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The maxillary vein: an anatomical narrative review with clinical implications for oral and maxillofacial surgeons
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The maxillary vein, despite its clinical significance, remains underexplored in anatomical literature. It plays a crucial role in venous drainage of the maxillofacial region and is closely associated with surgical procedures such as sagittal split ramus osteotomy, mandibuloplasty, and condylar or parotid surgeries. Due to its variable anatomy and proximity to critical structures, the maxillary vein poses a risk of significant hemorrhage if injured. Its small size and deep location make preoperative identification challenging, especially without contrast-enhanced imaging. Embryologically, the maxillary vein originates from the primitive maxillary vein and develops through complex anastomoses with other craniofacial veins. Anatomical studies have revealed several variations, including the presence of accessory mandibular foramina and unusual venous connections, which may increase surgical risk. Understanding the detailed anatomy and potential variations of the maxillary vein is essential for minimizing complications and improving surgical outcomes. Despite its importance, more anatomical and clinical research is needed to better define its course, variations, and implications in oral and maxillofacial surgery.
en-copyright=
kn-copyright=

en-aut-name=RaeburnKazzara
en-aut-sei=Raeburn
en-aut-mei=Kazzara
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakeshitaYohei
en-aut-sei=Takeshita
en-aut-mei=Yohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakakuraHiroaki
en-aut-sei=Takakura
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KikutaShogo
en-aut-sei=Kikuta
en-aut-mei=Shogo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KunisadaYuki
en-aut-sei=Kunisada
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SamridRarinthorn
en-aut-sei=Samrid
en-aut-mei=Rarinthorn
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=LoukasMarios
en-aut-sei=Loukas
en-aut-mei=Marios
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TubbsR. Shane
en-aut-sei=Tubbs
en-aut-mei=R. Shane
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=IwanagaJoe
en-aut-sei=Iwanaga
en-aut-mei=Joe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Anatomical Sciences, St. George’s University
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Dental and Oral Medical Center, Kurume University School of Medicine
kn-affil=

affil-num=5
en-affil=Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=
kn-affil=

affil-num=8
en-affil=Department of Anatomical Sciences, St. George’s University
kn-affil=

affil-num=9
en-affil=Department of Anatomical Sciences, St. George’s University
kn-affil=

affil-num=10
en-affil=Dental and Oral Medical Center, Kurume University School of Medicine
kn-affil=
en-keyword=Embryology
kn-keyword=Embryology
en-keyword=Anatomy
kn-keyword=Anatomy
en-keyword=Radiology
kn-keyword=Radiology
en-keyword=Cadaver
kn-keyword=Cadaver
en-keyword=Mandible
kn-keyword=Mandible
END

start-ver=1.4
cd-journal=joma
no-vol=25
cd-vols=
no-issue=1
article-no=
start-page=745
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250521
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Exploring the relationship between posture-dependent airway assessment in orthodontics: insights from kinetic MRI, cephalometric data, and three-dimensional MRI analysis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background Previous studies have assessed the upper airway using various examination methods, such as cephalometric imaging and magnetic resonance imaging (MRI). However, there is a significant gap in the research regarding the relationship between these different imaging modalities. This study compares airway assessments using kinetic MRI and cephalometric scans, examining their correlation with three dimensional (3D) MRI data.<br>
Materials and methods Kinetic MRI, cephalometric scans, and 3D MRI of forty-seven participants were used in the present study. Airway areas and widths were measured at the retropalatal, retroglossal, and hypopharyngeal levels in both kinetic MRI and cephalometric scans. Airway volumes were calculated from 3D MRI data. Statistical analyses, including the Wilcoxon Signed Rank test, Spearman correlation, and multiple linear regression, were performed to evaluate the data and identify significant differences, correlations, and prediction models, respectively.<br>
Results Significant differences were found between kinetic MRI and cephalometric scans. Cephalometric data showed larger airway areas and widths compared to kinetic MRI measurements. Although both cephalometric and kinetic MRI showed a correlation with 3D MRI, kinetic MRI demonstrated stronger correlations with 3D MRI airway volumes than cephalometric scans. According to our linear regression model equations, RPA-Max (maximum retropalatal airway area) and RPA (retropalatal airway area) can elucidate variations in RPV (retropalatal airway volume). RGA-Med (median retroglossal airway area) and RGA-Min (minimum retroglossal airway area) can explain variations in RGV (retroglossal airway volume). HPA (hypopharyngeal airway area) and ULHPAW-Max (maximum upper limit hypopharyngeal airway width) account for variations in HPV (hypopharyngeal airway volume). Additionally, TA-Max (maximum total airway area) can account for variations in TPV (total pharyngeal airway volume).ConclusionBoth cephalometric data and kinetic MRI data showed correlations with 3D MRI data. The shared posture of kinetic MRI and 3D MRI led to stronger correlations between these two modalities. Although cephalometric data had fewer correlations with 3D MRI and predictors for 3D airway volume, they were still significant. Our study highlights the complementary nature of kinetic MRI and cephalometric imaging, as both provide valuable information for airway assessment and exhibit significant correlations with 3D MRI data.
en-copyright=
kn-copyright=

en-aut-name=OkaNaoki
en-aut-sei=Oka
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HabumugishaJanvier
en-aut-sei=Habumugisha
en-aut-mei=Janvier
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakamuraMasahiro
en-aut-sei=Nakamura
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KataokaTomoki
en-aut-sei=Kataoka
en-aut-mei=Tomoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujisawaAtsuro
en-aut-sei=Fujisawa
en-aut-mei=Atsuro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KawanabeNoriaki
en-aut-sei=Kawanabe
en-aut-mei=Noriaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=IzawaTakashi
en-aut-sei=Izawa
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KamiokaHiroshi
en-aut-sei=Kamioka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Division of Oral and Maxillofacial Surgery, Tottori University
kn-affil=

affil-num=5
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Kinetic MRI
kn-keyword=Kinetic MRI
en-keyword=Posture
kn-keyword=Posture
en-keyword=Airway assessment
kn-keyword=Airway assessment
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=20
article-no=
start-page=eadv7488
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250516
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Structure of a photosystem I supercomplex from Galdieria sulphuraria close to an ancestral red alga
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Red algae exhibit unique photosynthetic adaptations, characterized by photosystem I (PSI) supercomplexes containing light-harvesting complexes (LHCs), forming PSI-LHCI supercomplexes. In this study, we solved the PSI-LHCI structure of Galdieria sulphuraria NIES-3638 at 2.19-angstrom resolution using cryo-electron microscopy, revealing a PSI monomer core associated with seven LHCI subunits. Structural analysis uncovered the absence of phylloquinones, the common secondary electron acceptor in PSI of photosynthetic organisms, suggesting adaptation to a benzoquinone-like molecule. Phylogenetic analysis suggests that G. sulphuraria retains traits characteristic of an ancestral red alga, including distinctive LHCI binding and interaction patterns. Variations in LHCI composition and interactions across red algae, particularly in red-lineage chlorophyll a/b-binding-like protein and red algal LHCs, highlight evolutionary divergence and specialization. These findings not only deepen our understanding of red algal PSI-LHCI diversification but also enable us to predict features of an ancestral red algal PSI-LHCI supercomplex, providing a framework to explore evolutionary adaptations from an ancestral red alga.
en-copyright=
kn-copyright=

en-aut-name=KatoKoji
en-aut-sei=Kato
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KumazawaMinoru
en-aut-sei=Kumazawa
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakajimaYoshiki
en-aut-sei=Nakajima
en-aut-mei=Yoshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SuzukiTakehiro
en-aut-sei=Suzuki
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=DohmaeNaoshi
en-aut-sei=Dohmae
en-aut-mei=Naoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ShenJian-Ren
en-aut-sei=Shen
en-aut-mei=Jian-Ren
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=IfukuKentaro
en-aut-sei=Ifuku
en-aut-mei=Kentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NagaoRyo
en-aut-sei=Nagao
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Research institute for interdisciplinary Science and Graduate School of environ-mental, life, natural Science and technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Agriculture, Kyoto University
kn-affil=

affil-num=3
en-affil=Research institute for interdisciplinary Science and Graduate School of environ-mental, life, natural Science and technology, Okayama University
kn-affil=

affil-num=4
en-affil=Biomolecular characterization Unit, RiKen center for Sustainable Resource Science
kn-affil=

affil-num=5
en-affil=Biomolecular characterization Unit, RiKen center for Sustainable Resource Science
kn-affil=

affil-num=6
en-affil=Research institute for interdisciplinary Science and Graduate School of environ-mental, life, natural Science and technology, Okayama University
kn-affil=

affil-num=7
en-affil=Graduate School of Agriculture, Kyoto University
kn-affil=

affil-num=8
en-affil=Faculty of Agriculture, Shizuoka University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=18
cd-vols=
no-issue=9
article-no=
start-page=1983
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250427
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Initial Bonding Performance to CAD/CAM Restorative Materials: The Impact of Stepwise Concentration Variation in 8-Methacryloxyoctyl Trimethoxy Silane and 3-Methacryloxypropyl Trimethoxy Silane on Feldspathic Ceramic, Lithium Disilicate Glass-Ceramic, and Polymer-Infiltrated Ceramic
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study investigated the effects of varying concentrations of two distinct silane agents, 8-methacryloxyoctyl trimethoxy silane (8-MOTS) and 3-methacryloxypropyl trimethoxy silane (γ-MPTS), on their initial bonding efficacy to feldspathic ceramic (FC), lithium disilicate glass-ceramic (LD) and polymer-infiltrated ceramic (PIC) specimens, in 10% increments for concentrations ranging from 10% to 40%. Shear bond strengths between the ceramic substrates and the luting material were assessed following 24 h incubation in distilled water. For FC, the median value of shear bond strength peaked at 20% of γ-MPTS (7.4 MPa), while 8-MOTS exhibited a concentration-dependent increase, reaching its highest value at 40% (13.1 MPa). For LD, γ-MPTS above 10% yielded similar strength median values (10.2 MPa), whereas 8-MOTS at 30% (15.8 MPa) and 40% (13.4 MPa) yielded higher strength values than at 10% (2.9 MPa) and 20% (4.1 MPa), with the highest median value exhibited at 30%. For PIC, both γ-MPTS and 8-MOTS demonstrated similarly low bond strength values which were not significantly different from the non-silane-treated specimens. When applied on silica-based FC and LD, silane revealed a concentration-dependent bonding effect, with 8-MOTS exhibiting superior bond strength to γ-MPTS. However, PIC, characterized by a high inorganic filler content, demonstrated limited bondability with both silanes.
en-copyright=
kn-copyright=

en-aut-name=MaruoYukinori
en-aut-sei=Maruo
en-aut-mei=Yukinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KuwaharaMiho
en-aut-sei=Kuwahara
en-aut-mei=Miho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YoshiharaKumiko
en-aut-sei=Yoshihara
en-aut-mei=Kumiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IrieMasao
en-aut-sei=Irie
en-aut-mei=Masao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NagaokaNoriyuki
en-aut-sei=Nagaoka
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YoshizaneMai
en-aut-sei=Yoshizane
en-aut-mei=Mai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MatsumotoTakuya
en-aut-sei=Matsumoto
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=AkiyamaKentaro
en-aut-sei=Akiyama
en-aut-mei=Kentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Prosthodontics, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Health Research Institute, National Institute of Advanced Industrial Science and Technology
kn-affil=

affil-num=4
en-affil=Department of Biomaterials, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School
kn-affil=

affil-num=6
en-affil=Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Biomaterials, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=silane coupling
kn-keyword=silane coupling
en-keyword=bond strength
kn-keyword=bond strength
en-keyword=ceramic
kn-keyword=ceramic
en-keyword=feldspathic
kn-keyword=feldspathic
en-keyword=lithium
kn-keyword=lithium
en-keyword=polymer-infiltrated ceramic
kn-keyword=polymer-infiltrated ceramic
en-keyword=CAD/CAM
kn-keyword=CAD/CAM
END

start-ver=1.4
cd-journal=joma
no-vol=137
cd-vols=
no-issue=1
article-no=
start-page=20
end-page=24
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Questionnaire survey of junior and mid-career otolaryngologists' attitudes towards clinical research
kn-title=若手・中堅耳鼻咽喉科医師の臨床研究に対する質問紙調査
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　Introduction : Clinical research is crucial for the advancement of medicine, but modern otolaryngologists' attitudes regarding clinical research have not been known. This study was conducted to survey the background, knowledge, and interest in clinical research among junior and mid-career otolaryngologists.<br>
　Methods : A questionnaire survey was distributed to 34 otolaryngologists with ?15 years' clinical experience working at Okayama University and its affiliated facilities. The respondents were divided into junior (non-specialists) and mid-career otolaryngologists (specialists) based on whether they were board-certified otolaryngologists. The survey assessed their background, understanding, and interest in clinical research.<br>
　Results : Twenty-nine otolaryngologists (83%) responded (10 junior and 19 mid-career otolaryngologists). There was significant individual variation in their interest and knowledge of clinical research. However, approximately half of the respondents indicated that they were not interested in and/or had never engaged in clinical research.<br>
　Conclusion : The data collected by this survey contribute to our understanding of the current state of clinical research engagement among junior and mid-career otolaryngologists, and they can serve as a basis for exploring future strategies to increase this engagement.
en-copyright=
kn-copyright=

en-aut-name=UraguchiKensuke
en-aut-sei=Uraguchi
en-aut-mei=Kensuke
kn-aut-name=浦口健介
kn-aut-sei=浦口
kn-aut-mei=健介
aut-affil-num=1
ORCID=

en-aut-name=YorifujiTakashi
en-aut-sei=Yorifuji
en-aut-mei=Takashi
kn-aut-name=頼藤貴志
kn-aut-sei=頼藤
kn-aut-mei=貴志
aut-affil-num=2
ORCID=

en-aut-name=TakaoSoshi
en-aut-sei=Takao
en-aut-mei=Soshi
kn-aut-name=高尾総司
kn-aut-sei=高尾
kn-aut-mei=総司
aut-affil-num=3
ORCID=

en-aut-name=SugayaAkiko
en-aut-sei=Sugaya
en-aut-mei=Akiko
kn-aut-name=菅谷明子
kn-aut-sei=菅谷
kn-aut-mei=明子
aut-affil-num=4
ORCID=

en-aut-name=AndoMizuo
en-aut-sei=Ando
en-aut-mei=Mizuo
kn-aut-name=安藤瑞生
kn-aut-sei=安藤
kn-aut-mei=瑞生
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　疫学・衛生学

affil-num=2
en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科　疫学・衛生学

affil-num=3
en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科　疫学・衛生学

affil-num=4
en-affil=Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学学術研究院医歯薬学域　耳鼻咽喉・頭頸部外科学

affil-num=5
en-affil=Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学学術研究院医歯薬学域　耳鼻咽喉・頭頸部外科学
en-keyword=臨床研究 (clinical research)
kn-keyword=臨床研究 (clinical research)
en-keyword=統計解析 (statistical analysis)
kn-keyword=統計解析 (statistical analysis)
en-keyword=ビッグデータ (bigdata)
kn-keyword=ビッグデータ (bigdata)
en-keyword=質問紙調査 (questionnaire survey)
kn-keyword=質問紙調査 (questionnaire survey)
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=8
article-no=
start-page=e70793
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250418
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Genomic Differences and Distinct TP53 Mutation Site-Linked Chemosensitivity in Early- and Late-Onset Gastric Cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Gastric cancer (GC) in younger patients often exhibits aggressive behavior and a poorer prognosis than that in older patients. Although the clinical differences may stem from oncogenic gene variations, it is unclear whether genetic differences exist between these groups. This study compared the genetic profiles of early- and late-onset GC and evaluated their impact on treatment outcomes.<br>
Methods: We analyzed genetic data from 1284 patients with GC in the Japanese nationwide Center for Cancer Genomics and Advanced Therapeutics (C-CAT) database, comparing early-onset (<= 39 years; n = 143) and late-onset (>= 65 years; n = 1141) groups. The influence of TP53 mutations on the time to treatment failure (TTF) with platinum-based chemotherapy and the sensitivity of cancer cells with different TP53 mutation sites to oxaliplatin were assessed in vitro.<br>
Results: Early- and late-onset GC showed distinct genetic profiles, with fewer neoantigen-associated genetic changes observed in early-onset cases. In particular, TP53 has distinct mutation sites; R175H and R273 mutations are more frequent in early- and late-onset GC, respectively. The R175H mutation showed higher sensitivity to oxaliplatin in vitro, consistent with the longer TTF in early-onset patients (17.3 vs. 7.0 months, p = 0.013) when focusing on the patients with TP53 mutations.<br>
Conclusion: Genomic differences, particularly in TP53 mutation sites, between early- and late-onset GC support the need for age-specific treatment strategies.
en-copyright=
kn-copyright=

en-aut-name=KamioTomohiro
en-aut-sei=Kamio
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KonoYoshiyasu
en-aut-sei=Kono
en-aut-mei=Yoshiyasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HirosunaKensuke
en-aut-sei=Hirosuna
en-aut-mei=Kensuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OzatoToshiki
en-aut-sei=Ozato
en-aut-mei=Toshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamamotoHideki
en-aut-sei=Yamamoto
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HirasawaAkira
en-aut-sei=Hirasawa
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=EnnishiDaisuke
en-aut-sei=Ennishi
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TomidaShuta
en-aut-sei=Tomida
en-aut-mei=Shuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OtsukaMotoyuki
en-aut-sei=Otsuka
en-aut-mei=Motoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Clinical Genomic Medicine, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Clinical Genomic Medicine, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Center for Comprehensive Genomic Medicine, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Center for Comprehensive Genomic Medicine, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Center for Comprehensive Genomic Medicine, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=comprehensive genomic profiling
kn-keyword=comprehensive genomic profiling
en-keyword=early-onset gastric cancer
kn-keyword=early-onset gastric cancer
en-keyword=oxaliplatin
kn-keyword=oxaliplatin
en-keyword=TP53
kn-keyword=TP53
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=6
article-no=
start-page=668
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Robustness of Machine Learning Predictions for Determining Whether Deep Inspiration Breath-Hold Is Required in Breast Cancer Radiation Therapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background/Objectives: Deep inspiration breath-hold (DIBH) is a commonly used technique to reduce the mean heart dose (MHD), which is critical for minimizing late cardiac side effects in breast cancer patients undergoing radiation therapy (RT). Although previous studies have explored the potential of machine learning (ML) to predict which patients might benefit from DIBH, none have rigorously assessed ML model performance across various MHD thresholds and parameter settings. This study aims to evaluate the robustness of ML models in predicting the need for DIBH across different clinical scenarios. Methods: Using data from 207 breast cancer patients treated with RT, we developed and tested ML models at three MHD cut-off values (240, 270, and 300 cGy), considering variations in the number of independent variables (three vs. six) and folds in the cross-validation (three, four, and five). Robustness was defined as achieving high F2 scores and low instability in predictive performance. Results: Our findings indicate that the decision tree (DT) model demonstrated consistently high robustness at 240 and 270 cGy, while the random forest model performed optimally at 300 cGy. At 240 cGy, a threshold critical to minimize late cardiac risks, the DT model exhibited stable predictive power, reducing the risk of overestimating DIBH necessity. Conclusions: These results suggest that the DT model, particularly at lower MHD thresholds, may be the most reliable for clinical applications. By providing a tool for targeted DIBH implementation, this model has the potential to enhance patient-specific treatment planning and improve clinical outcomes in RT.
en-copyright=
kn-copyright=

en-aut-name=Al-HammadWlla E.
en-aut-sei=Al-Hammad
en-aut-mei=Wlla E.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KurodaMasahiro
en-aut-sei=Kuroda
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Al JamalJamal, Ghaida
en-aut-sei=Al Jamal
en-aut-mei=Jamal, Ghaida
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FujikuraMamiko
en-aut-sei=Fujikura
en-aut-mei=Mamiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KamizakiRyo
en-aut-sei=Kamizaki
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KurodaKazuhiro
en-aut-sei=Kuroda
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YoshidaSuzuka
en-aut-sei=Yoshida
en-aut-mei=Suzuka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NakamuraYoshihide
en-aut-sei=Nakamura
en-aut-mei=Yoshihide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OitaMasataka
en-aut-sei=Oita
en-aut-mei=Masataka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TanabeYoshinori
en-aut-sei=Tanabe
en-aut-mei=Yoshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SugimotoKohei
en-aut-sei=Sugimoto
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=SugiantoIrfan
en-aut-sei=Sugianto
en-aut-mei=Irfan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=BarhamMajd
en-aut-sei=Barham
en-aut-mei=Majd
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=TekikiNouha
en-aut-sei=Tekiki
en-aut-mei=Nouha
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=HisatomiMiki
en-aut-sei=Hisatomi
en-aut-mei=Miki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=AsaumiJunichi
en-aut-sei=Asaumi
en-aut-mei=Junichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Oral Medicine and Oral Surgery, Faculty of Dentistry, Jordan University of Science and Technology
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Graduate School of Interdisciplinary Sciences and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=10
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=11
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Oral Radiology, Faculty of Dentistry, Hasanuddin University
kn-affil=

affil-num=13
en-affil=Department of Dentistry and Dental Surgery, College of Medicine and Health Sciences, An-Najah National University
kn-affil=

affil-num=14
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=15
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=16
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=breast cancer
kn-keyword=breast cancer
en-keyword=radiation therapy
kn-keyword=radiation therapy
en-keyword=heart dose
kn-keyword=heart dose
en-keyword=cut-off value
kn-keyword=cut-off value
en-keyword=machine learning
kn-keyword=machine learning
en-keyword=robustness
kn-keyword=robustness
en-keyword=instability
kn-keyword=instability
en-keyword=F2 score
kn-keyword=F2 score
en-keyword=deep inspiration breath-hold technique
kn-keyword=deep inspiration breath-hold technique
en-keyword=computed tomography
kn-keyword=computed tomography
END

start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=
article-no=
start-page=11
end-page=27
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=19911115
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Variations of Residential Groups in Okayama City, Japan
kn-title=地方都市における町内会の類型 ――岡山市の事例――
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NOBEMASAO
en-aut-sei=NOBE
en-aut-mei=MASAO
kn-aut-name=野邊政雄
kn-aut-sei=野邊
kn-aut-mei=政雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=59
cd-vols=
no-issue=
article-no=
start-page=101
end-page=122
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250328
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Impact of Free Government Healthcare Insurance on The Utilization of Healthcare Services in Vietnam
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　This study investigates the impact of the Free Government Healthcare Insurance (FGHI) scheme on healthcare utilization patterns among enrolled households. Utilizing Tobit regression and Nearest Neighbor Matching (NNM), the analysis revealed a significant positive correlation between scheme enrollment and increased healthcare checkup frequency. However, demographic and geographic variations were evident in the scheme's impact, with ethnic minorities and rural households experiencing a more pronounced rise in healthcare visits compared to the majority group and urban residents. These findings underscore the necessity for tailored policy interventions to address disparities across diverse demographic and geographic strata. Moreover, the FGHI scheme demonstrated effectiveness in encouraging healthcare utilization, particularly among specific demographic groups. This study's insights advocate for more nuanced policy frameworks that consider demographic and geographic nuances, ensuring equitable access to healthcare services for all segments of society.
en-copyright=
kn-copyright=

en-aut-name=Do Thi Hoai Giang
en-aut-sei=Do Thi Hoai Giang
en-aut-mei=
kn-aut-name=ド ティ ホアイ ジャン
kn-aut-sei=ド ティ ホアイ ジャン
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科
en-keyword=Free Government Healthcare Insurance
kn-keyword=Free Government Healthcare Insurance
en-keyword=Nearest Neighbor Matching
kn-keyword=Nearest Neighbor Matching
en-keyword=Vietnam Healthcare
kn-keyword=Vietnam Healthcare
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=1
article-no=
start-page=36
end-page=43
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=2025
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evaluation of the temporal behavior of fulvic acid iron in Asahi River, Okayama, Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Iron is essential for biogeochemical processes in aquatic ecosystems, but its riverine concentration can be affected by environmental conditions. This study assessed weekly fulvic acid iron (FAFe) concentration at a single sampling site in Asahi River from 2022?2023 to explore the differences in the temporal scales. The objectives of this study were to evaluate the effects of physicochemical properties of the river on the concentration of FAFe, analyze the concentration of FAFe in spring, summer, autumn and winter, and assess the relationship between FAFe concentration and land use types of the watershed. The results indicated that physicochemical parameters, such as pH and surface water temperature (SWT) seemed to influence FAFe concentration (p < 0.05). Hydrological dynamics influenced FAFe concentration and transport, revealing an increasing trend during spring (p < 0.001) and summer (p = 0.05), with non-significant trends during autumn and winter (p > 0.05). FAFe exhibited a strong positive correlation with total organic carbon (TOC) (p < 0.001). Upland fields significantly influenced FAFe concentration (p < 0.01) through runoff with abundant NO3? and PO43? into the river. Thus, FAFe concentration in Asahi River was influenced by pH, SWT, TOC, hydrological regime, and agricultural runoff.
en-copyright=
kn-copyright=

en-aut-name=YengehRohdof Lactem
en-aut-sei=Yengeh
en-aut-mei=Rohdof Lactem
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SomuraHiroaki
en-aut-sei=Somura
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MoroizumiToshitsugu
en-aut-sei=Moroizumi
en-aut-mei=Toshitsugu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MoriYasushi
en-aut-sei=Mori
en-aut-mei=Yasushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MaedaMorihiro
en-aut-sei=Maeda
en-aut-mei=Morihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=dissolved iron
kn-keyword=dissolved iron
en-keyword=seasonal variation
kn-keyword=seasonal variation
en-keyword=dissolved organic matter
kn-keyword=dissolved organic matter
en-keyword=fulvic acid iron
kn-keyword=fulvic acid iron
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=1
article-no=
start-page=JAMDSM0001
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=2025
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Development of tool life prediction system for square end-mills based on database of servo motor current value
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Accurate prediction of tool life is crucial for reducing production costs and enhancing quality in the machining process. However, such predictions often rely on empirical knowledge, which may limit inexperienced engineers to reliably obtain accurate predictions. This study explores a method to predict the tool life of a cutting machine using servo motor current data collected during the initial stages of tool wear, which is a cost-effective approach. The LightGBM model was identified as suitable for predicting tool life from current data, given the challenges associated with predicting from the average variation of current values. By identifying and utilizing the top 50 features from the current data for prediction, the accuracy of tool life prediction in the early wear stage improved. As this prediction method was developed based on current data obtained during the very early wear stage in experiments with square end-mills, it was tested on extrapolated data using different end-mill diameters. The findings revealed average accuracy rates of 71.2% and 69.4% when using maximum machining time and maximum removal volume as thresholds, respectively.
en-copyright=
kn-copyright=

en-aut-name=KODAMAHiroyuki
en-aut-sei=KODAMA
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SUZUKIMakoto
en-aut-sei=SUZUKI
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OHASHIKazuhito
en-aut-sei=OHASHI
en-aut-mei=Kazuhito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate school of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=
en-keyword=Milling
kn-keyword=Milling
en-keyword=LightGBM
kn-keyword=LightGBM
en-keyword=Tool life prediction
kn-keyword=Tool life prediction
en-keyword=Square end-mill
kn-keyword=Square end-mill
en-keyword=Servo motor current
kn-keyword=Servo motor current
END

start-ver=1.4
cd-journal=joma
no-vol=391
cd-vols=
no-issue=
article-no=
start-page=158
end-page=176
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250215
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Magnesium isotope composition of volcanic rocks from cold and warm subduction zones: Implications for the recycling of subducted serpentinites and carbonates
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Magnesium (Mg) isotopes are regarded as a sensitive tracer to the contribution from subducted serpentinites and carbonates. However, the source, distribution, and controlling factors of the Mg isotope composition of arc magmas remain unclear. In this study, we investigated the intra-arc and inter-arc variations in Mg isotope compositions of volcanic rocks from two typical cold subduction zones [NE Japan (NEJ) and Izu arcs] and a typical hot subduction zone [SW Japan (SWJ) arc] to address the question. The volcanic rocks from the frontal-arc regions of NEJ and Izu have isotopically heavy Mg (δ26Mg = ?0.20 to ?0.08 ‰) compared to the mantle-like δ26Mg values of most of volcanic rocks from SWJ and the rear regions of NEJ and Izu arcs (?0.28 to ?0.17 ‰). It is also worth noting that NEJ arc includes samples with δ26Mg values (?0.61 to ?0.39 ‰) significantly lower than the mantle, but similar to the < 110 Ma intra-continental basalts from eastern China, which is the first observation in modern arc rocks. No obvious effects of post-eruptive alteration, fractional crystallization, partial melting, or the addition of silicate-rich sediment and oceanic crust components could be identified in the Mg isotope compositions of these volcanic rocks. By contrast, the correlations between the δ26Mg values and the proxy for serpentinite component (i.e., 11B/10B and Nb/B ratios) indicate that the component exerts a strong control on the Mg-isotopic signature of these arc rocks. Considering metamorphic reactions in subduction lithologies under P-T conditions postulated for these arcs, the variations in δ26Mg values of these arc magmas are unlikely to have been controlled by dehydration of serpentinites in subducted oceanic lithosphere (slab serpentinite). Instead, the high-δ26Mg values of frontal-arc rocks are delivered by the fluids from serpentinite formed in the lowermost part of the sub-arc mantle (mantle wedge serpentinite) in channelized flow. Comparatively, such a high-δ26Mg signature is invisible in volcanic rocks from rear-arc regions of NEJ and Izu, and the entire SWJ, suggesting that the major Mg carriers in subducted serpentinites (e.g., talc, chlorite, and serpentine) were broken down completely before subducted slabs reached the depth beneath these volcanoes. Moreover, the volcanic rocks with low δ26Mg values from the rear arc of NEJ are characterized by high La/Yb and U/Nb ratios as well as low Ti/Eu, Ti/Ti*, and Hf/Hf* ratios, suggesting the involvements of carbonates in their magma sources. The quantitative modeling suggests that < 20 % of sedimentary carbonate (dolomite) was recycled into their mantle source, revealing that Mg-rich carbonate could be incorporated into a deep mantle wedge at rear-arc depths of 150?400 km in subduction zones.
en-copyright=
kn-copyright=

en-aut-name=ZhangWei
en-aut-sei=Zhang
en-aut-mei=Wei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KitagawaHiroshi
en-aut-sei=Kitagawa
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HuangFang
en-aut-sei=Huang
en-aut-mei=Fang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=2
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=3
en-affil=CAS Key Laboratory of Crust-Mantle Materials and Environments, School of Earth and Space Sciences, University of Science and Technology of China
kn-affil=
en-keyword=Magnesium isotopes
kn-keyword=Magnesium isotopes
en-keyword=Arc magmas
kn-keyword=Arc magmas
en-keyword=Mantle wedge serpentinite
kn-keyword=Mantle wedge serpentinite
en-keyword=Slab serpentinite
kn-keyword=Slab serpentinite
en-keyword=Carbonate recycle
kn-keyword=Carbonate recycle
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=3
article-no=
start-page=100105
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202412
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Capturing chronological variation in L2 speech through lexical measurements and regression analysis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study aims to bridge gaps in current research by analyzing a longitudinal spoken learner corpus of low-proficiency English learners. We investigated the chronological variation in lexical measurements in second language (L2) speaking production, focusing on data from 104 low-proficiency learners elicited eight times over 23 months. Our findings show that measures such as the number of different words and type-token ratio are effective indicators of L2 speaking development, whereas the use of sophisticated vocabulary was not significantly correlated with learning duration. These results suggest that in the early stages of L2 acquisition, speaking skills are influenced primarily by lexical variation. This finding underscores the importance of lexical variation as a key factor in novice-level L2 speaking proficiency.
en-copyright=
kn-copyright=

en-aut-name=AbeMariko
en-aut-sei=Abe
en-aut-mei=Mariko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KobayashiYuichiro
en-aut-sei=Kobayashi
en-aut-mei=Yuichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KondoYusuke
en-aut-sei=Kondo
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Okayama University
kn-affil=

affil-num=2
en-affil=Nihon University
kn-affil=

affil-num=3
en-affil=Waseda University
kn-affil=
en-keyword=Longitudinal learner corpus
kn-keyword=Longitudinal learner corpus
en-keyword=Second language speaking
kn-keyword=Second language speaking
en-keyword=Low-proficiency learner
kn-keyword=Low-proficiency learner
en-keyword=Automatic analyzer
kn-keyword=Automatic analyzer
en-keyword=Regression analysis
kn-keyword=Regression analysis
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=1
article-no=
start-page=42
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241126
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Genotypes and phenotypes of neurofibromatosis type 1 patients in Japan: A Hereditary Tumor Cohort Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Neurofibromatosis type 1 (NF1) presents with a broad spectrum of clinical manifestations, including an increased risk of tumor development and hypertension. Comprehensive data on genotype?phenotype correlations in patients with NF1 are limited. Therefore, in this study, we aimed to elucidate the detailed genetic and clinical characteristics of NF1 in a hereditary tumor cohort. We performed sequencing and copy number assays in a clinical laboratory and analyzed the clinical data of 44 patients with suspected NF1. Germline pathogenic variants were detected in 36 patients (81.8%), and 20.7% of the variants were novel. Notably, 40.0% of adult patients presented with malignancies; female breast cancer occurred in 20.0% of patients, which was a higher rate than that previously reported. Hypertension was observed in 30.6% of the adult patients, with one patient experiencing sudden death and another developing pheochromocytoma. Three patients with large deletions in NF1 exhibited prominent cutaneous, skeletal, and neurological manifestations. These results highlight the importance of regular surveillance, particularly for patients with malignancies and hypertension. Our findings provide valuable insights for genetic counseling and clinical management, highlighting the multiple health risks associated with NF1 and the need for comprehensive and multidisciplinary care.
en-copyright=
kn-copyright=

en-aut-name=FutagawaMashu
en-aut-sei=Futagawa
en-aut-mei=Mashu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkazakiTetsuya
en-aut-sei=Okazaki
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakataEiji
en-aut-sei=Nakata
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FukanoChika
en-aut-sei=Fukano
en-aut-mei=Chika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OsumiRisa
en-aut-sei=Osumi
en-aut-mei=Risa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KatoFumino
en-aut-sei=Kato
en-aut-mei=Fumino
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=UrakawaYusaku
en-aut-sei=Urakawa
en-aut-mei=Yusaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YamamotoHideki
en-aut-sei=Yamamoto
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=HirasawaAkira
en-aut-sei=Hirasawa
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Clinical Genetics and Genomic Medicine, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Clinical Genetics and Genomic Medicine, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Genetic Medicine, School of Medicine, Fujita Health University
kn-affil=

affil-num=8
en-affil=Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=17
cd-vols=
no-issue=5
article-no=
start-page=434
end-page=448
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230905
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effect of Vibration Behavior in Low-Frequency Vibration Cutting on Surface Properties of Workpiece
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　The objective of this study was to determine the effect of vibration behavior on workpiece surface properties in low-frequency vibration cutting. The effects of the parameters that determine vibration behavior on surface roughness were quantitatively evaluated through a comparison with other cutting conditions. Furthermore, by clarifying how the surface properties of the workpiece, such as roughness, roundness, and cross-sectional curves, change depending on the vibration behavior, a search for optimal conditions for low-frequency vibration cutting was conducted. The best surface properties were obtained under the condition of spindle rotation per vibration E=4.5. By using a value close to the minimum possible spindle rotation R=0.5 when the workpiece is retracted, it is expected to be effective in suppressing the variation in surface roughness at each phase angle; this variation is characteristic of low-frequency vibration cutting. Workpieces machined under low-frequency vibration conditions such as (E=2.5, R=1.0) and (E=3.5, R=1.0) were found to form characteristic surface patterns on the workpiece surface owing to a phenomenon in which the depth of the cut to the workpiece changes.
en-copyright=
kn-copyright=

en-aut-name=KodamaHiroyuki
en-aut-sei=Kodama
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsunoShota
en-aut-sei=Matsuno
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShibataNaoyuki
en-aut-sei=Shibata
en-aut-mei=Naoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OhashiKazuhito
en-aut-sei=Ohashi
en-aut-mei=Kazuhito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Okayama University
kn-affil=

affil-num=2
en-affil=Okayama University
kn-affil=

affil-num=3
en-affil=Okayama University
kn-affil=

affil-num=4
en-affil=Okayama University
kn-affil=
en-keyword=low-frequency vibration cutting
kn-keyword=low-frequency vibration cutting
en-keyword=vibration behavior
kn-keyword=vibration behavior
en-keyword=surface roughness
kn-keyword=surface roughness
en-keyword=cross-sectional curve
kn-keyword=cross-sectional curve
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=
article-no=
start-page=78366
end-page=78378
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=2024
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Aromug: A Mug-Type Olfactory Interface to Enhance the Sweetness Perception of Beverages
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Sugary beverages are a significant contributor to sugar consumption, and their excessive consumption is associated with increased risks of elevated blood glucose levels and diabetes. Many individuals have a strong preference for sugary beverages and often find beverages with lower sugar content to be less satisfying. Attempts to switch to less sugary options are frequently short-lived, leading to a return to higher-sugar beverages. Recognizing that 75 ? 95% of taste perception is influenced by scent, we investigated a scent-based approach to reduce sugar intake while preserving the perception of sweetness. This study introduces an olfactory interface in the form of a mug named “Aromug,” designed to emit a sweet scent in sync with the drinking action. Aromug incorporates motion sensing and scent presentation functions to enhance the perceived sweetness of a beverage, thereby encouraging a gradual reduction in sugar intake. Our experiments, involving 33 participants, demonstrated that the combined scents of sugar-free coffee and chocolate increased the perception of sweetness (p =1.641×10?2 ). The study also found that the simultaneous presentation of scent and visual cues improved taste satisfaction and sweetness perception. Additionally, we observed variations in sweetness preference related to age and frequency of coffee consumption. It was particularly observed that people in their 20s and those who frequently drink coffee tend to perceive the taste of beverages as sweeter. This suggests a potential for Aromug to customize the scent experience based on individual preferences, offering a novel way to encourage healthier beverage choices.
en-copyright=
kn-copyright=

en-aut-name=MayumiDaiki
en-aut-sei=Mayumi
en-aut-mei=Daiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakamuraYugo
en-aut-sei=Nakamura
en-aut-mei=Yugo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MatsudaYuki
en-aut-sei=Matsuda
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MisakiShinya
en-aut-sei=Misaki
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YasumotoKeiichi
en-aut-sei=Yasumoto
en-aut-mei=Keiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Science and Technology, Nara Institute of Science and Technology
kn-affil=

affil-num=2
en-affil=Faculty of Information Science and Electrical Engineering, Kyushu University
kn-affil=

affil-num=3
en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Science and Technology, Nara Institute of Science and Technology
kn-affil=

affil-num=5
en-affil=Graduate School of Science and Technology, Nara Institute of Science and Technology
kn-affil=
en-keyword=Olfaction
kn-keyword=Olfaction
en-keyword=olfactory interfaces
kn-keyword=olfactory interfaces
en-keyword=olfactory display
kn-keyword=olfactory display
en-keyword=scents
kn-keyword=scents
en-keyword=taste evaluation
kn-keyword=taste evaluation
en-keyword=smell
kn-keyword=smell
en-keyword=olfactory perception
kn-keyword=olfactory perception
en-keyword=behavior change support
kn-keyword=behavior change support
END

start-ver=1.4
cd-journal=joma
no-vol=60
cd-vols=
no-issue=
article-no=
start-page=104813
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202412
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Petrological characterization for material provenance of haniwa earthenware from mounded tombs in the Kibi region, Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To determine the provenance of the materials used in the production of haniwa earthenware unearthed from mounded tombs (kofun) in the Kibi region (modern Okayama Prefecture) during the Kofun period (late 3rd ? 6th century CE) of Japan, we carried out petrological analyses of haniwa sherds, including optical microscopy, X-ray diffractometry, X-ray fluorescence spectroscopy, and electron-probe analysis. The 25 haniwa sherds analyzed from 12 representative mounded tombs are composed of mineral and rock inclusions with variable grain size set in a clay matrix. The dominant inclusions are quartz, K-feldspar, and plagioclase, associated with minor amounts of amphibole, volcanic glass, and granitic rocks in all the haniwa sherds, and small amounts of hornfels, quartz rock, and accessory minerals, including mica, ilmenite, and chromite, in some of the sherds. Amphibole and plagioclase have compositional variations indicative of the mixing of tephra and granitic components. The compositions of volcanic glass inclusions are similar to those of the Aira-Tanzawa and Kikai-Akahoya tephras widely distributed in southwestern Japan. Bulk chemical compositions show magmatic differentiation trends, which are variable between individual tombs. From these results, it is concluded that the paste materials of haniwa in the Kibi region were commonly derived from weathered granitic rocks mixed with minor amounts of three widespread tephras. The variations of chemical and mineralogical compositions are probably the reflection of local geologic settings, suggesting the presence of specific mining sites of paste materials around each tomb. The mining sites could be located at the bases of hills of granitic rocks covered by widespread tephras and in some cases, near the flood plain of big river systems.
en-copyright=
kn-copyright=

en-aut-name=NozakaToshio
en-aut-sei=Nozaka
en-aut-mei=Toshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhbayashiNaoya
en-aut-sei=Ohbayashi
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TodaYuki
en-aut-sei=Toda
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SugiuraKanako
en-aut-sei=Sugiura
en-aut-mei=Kanako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NozakiTakahiro
en-aut-sei=Nozaki
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KimuraOsamu
en-aut-sei=Kimura
en-aut-mei=Osamu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MatsumotoNaoko
en-aut-sei=Matsumoto
en-aut-mei=Naoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SeikeAkira
en-aut-sei=Seike
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Earth Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Earth Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Earth Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Archaeology, Okayama University
kn-affil=

affil-num=5
en-affil=Research Institute for the Dynamics of Civilizations, Okayama University
kn-affil=

affil-num=6
en-affil=Research Institute for the Dynamics of Civilizations, Okayama University
kn-affil=

affil-num=7
en-affil=Research Institute for the Dynamics of Civilizations, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Archaeology, Okayama University
kn-affil=
en-keyword=Haniwa
kn-keyword=Haniwa
en-keyword=Paste material
kn-keyword=Paste material
en-keyword=Provenance
kn-keyword=Provenance
en-keyword=Kofun
kn-keyword=Kofun
en-keyword=Kibi
kn-keyword=Kibi
en-keyword=Japan
kn-keyword=Japan
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=10
article-no=
start-page=e087657
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241008
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Decline in and recovery of fertility rates after COVID-19-related state of emergency in Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Introduction The COVID-19 pandemic led to a decline in fertility rates worldwide. Although many regions have experienced a temporary drop in fertility rates with the spread of the infection, subsequent recovery has varied across countries. This study aimed to evaluate the impact of COVID-19 infection rates and regional sociodemographic factors on the recovery of fertility rates in Japan following the state of emergency.<br>
Methods This study examined prefectural fertility data from before the COVID-19 pandemic to forecast fertility rates up to 2022 using a seasonal autoregressive integrated moving average model. A regression analysis was conducted on fertility rates during the first state of emergency and the subsequent recovery rate with respect to the number of new COVID-19 cases and sociodemographic factors specific to each prefecture.<br>
Results During the first state of emergency, the monthly fertility rate decreased by an average of -13.8% (SD: 6.26, min: -28.78, max: 0.15) compared with the previous year. Over the following 22 months, the average fertility recovery rate was +2.31% (SD: 3.57; min: -8.55, max: 19.54). Multivariate analysis of the impact of the pandemic on fertility changes during the first emergency indicated a negative correlation between new COVID-19 cases per capita and the proportion of nuclear households. No significant correlation was found between fertility recovery rate and new COVID-19 cases or emergency duration. When classifying fertility rate fluctuation patterns before and after the emergency into four clusters, variations were noted in the proportion of the elderly population, marriage divorce rate and the number of internet searches related to pregnancy intentions across the clusters.<br>
Conclusions No association was found between pregnancy intentions related to the spread of infection, such as the number of new cases and the fertility recovery rate following the first state of emergency. Differences in the patterns of decline and recovery during the pandemic were observed based on population composition and internet searches for infection and pregnancy across different prefectures.
en-copyright=
kn-copyright=

en-aut-name=MitomaTomohiro
en-aut-sei=Mitoma
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MakiJota
en-aut-sei=Maki
en-aut-mei=Jota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OobaHikaru
en-aut-sei=Ooba
en-aut-mei=Hikaru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MasuyamaHisashi
en-aut-sei=Masuyama
en-aut-mei=Hisashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Obstetric and Gynecology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Obstetric and Gynecology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Obstetric and Gynecology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Obstetric and Gynecology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=1
article-no=
start-page=17591
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240730
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Training high-performance deep learning classifier for diagnosis in oral cytology using diverse annotations
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The uncertainty of true labels in medical images hinders diagnosis owing to the variability across professionals when applying deep learning models. We used deep learning to obtain an optimal convolutional neural network (CNN) by adequately annotating data for oral exfoliative cytology considering labels from multiple oral pathologists. Six whole-slide images were processed using QuPath for segmenting them into tiles. The images were labeled by three oral pathologists, resulting in 14,535 images with the corresponding pathologists' annotations. Data from three pathologists who provided the same diagnosis were labeled as ground truth (GT) and used for testing. We investigated six models trained using the annotations of (1) pathologist A, (2) pathologist B, (3) pathologist C, (4) GT, (5) majority voting, and (6) a probabilistic model. We divided the test by cross-validation per slide dataset and examined the classification performance of the CNN with a ResNet50 baseline. Statistical evaluation was performed repeatedly and independently using every slide 10 times as test data. For the area under the curve, three cases showed the highest values (0.861, 0.955, and 0.991) for the probabilistic model. Regarding accuracy, two cases showed the highest values (0.988 and 0.967). For the models using the pathologists and GT annotations, many slides showed very low accuracy and large variations across tests. Hence, the classifier trained with probabilistic labels provided the optimal CNN for oral exfoliative cytology considering diagnoses from multiple pathologists. These results may lead to trusted medical artificial intelligence solutions that reflect diverse diagnoses of various professionals.
en-copyright=
kn-copyright=

en-aut-name=SukegawaShintaro
en-aut-sei=Sukegawa
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TanakaFuta
en-aut-sei=Tanaka
en-aut-mei=Futa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakanoKeisuke
en-aut-sei=Nakano
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HaraTakeshi
en-aut-sei=Hara
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OchiaiTakanaga
en-aut-sei=Ochiai
en-aut-mei=Takanaga
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ShimadaKatsumitsu
en-aut-sei=Shimada
en-aut-mei=Katsumitsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=InoueYuta
en-aut-sei=Inoue
en-aut-mei=Yuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakiYoshihiro
en-aut-sei=Taki
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NakaiFumi
en-aut-sei=Nakai
en-aut-mei=Fumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=NakaiYasuhiro
en-aut-sei=Nakai
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=IshihamaTakanori
en-aut-sei=Ishihama
en-aut-mei=Takanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=MiyazakiRyo
en-aut-sei=Miyazaki
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=MurakamiSatoshi
en-aut-sei=Murakami
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=NagatsukaHitoshi
en-aut-sei=Nagatsuka
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=MiyakeMinoru
en-aut-sei=Miyake
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

affil-num=1
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Electrical, Electronic and Computer Engineering, Faculty of Engineering, Gifu University
kn-affil=

affil-num=3
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Electrical, Electronic and Computer Engineering, Faculty of Engineering, Gifu University
kn-affil=

affil-num=5
en-affil=Division of Oral Pathogenesis and Disease Control, Department of Oral Pathology, Asahi University School of Dentistry
kn-affil=

affil-num=6
en-affil=Department of Oral Pathology, Graduate School of Oral Medicine, Matsumoto Dental University
kn-affil=

affil-num=7
en-affil=Department of Electrical, Electronic and Computer Engineering, Faculty of Engineering, Gifu University
kn-affil=

affil-num=8
en-affil=Department of Electrical, Electronic and Computer Engineering, Faculty of Engineering, Gifu University
kn-affil=

affil-num=9
en-affil=Department of Oral and Maxillofacial Surgery, Kagawa University Faculty of Medicine
kn-affil=

affil-num=10
en-affil=Department of Oral and Maxillofacial Surgery, Kagawa University Faculty of Medicine
kn-affil=

affil-num=11
en-affil=Department of Oral and Maxillofacial Surgery, Kagawa University Faculty of Medicine
kn-affil=

affil-num=12
en-affil=Stony Brook Cancer Center, Stony Brook University
kn-affil=

affil-num=13
en-affil=Department of Oral Pathology, Graduate School of Oral Medicine, Matsumoto Dental University
kn-affil=

affil-num=14
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=15
en-affil=Department of Oral and Maxillofacial Surgery, Kagawa University Faculty of Medicine
kn-affil=
en-keyword=Deep learning
kn-keyword=Deep learning
en-keyword=Oral cytology
kn-keyword=Oral cytology
en-keyword=Classification
kn-keyword=Classification
en-keyword=Convolutional neural network
kn-keyword=Convolutional neural network
en-keyword=Probabilistic labeling
kn-keyword=Probabilistic labeling
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=15
article-no=
start-page=2930
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240724
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Performance Investigations of VSLAM and Google Street View Integration in Outdoor Location-Based Augmented Reality under Various Lighting Conditions
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The growing demand for Location-based Augmented Reality (LAR) experiences has driven the integration of Visual Simultaneous Localization And Mapping (VSLAM) with Google Street View (GSV) to enhance the accuracy. However, the impact of the ambient light intensity on the accuracy and reliability is underexplored, posing significant challenges in outdoor LAR implementations. This paper investigates the impact of light conditions on the accuracy and reliability of the VSLAM/GSV integration approach in outdoor LAR implementations. This study fills a gap in the current literature and offers valuable insights into vision-based approach implementation under different light conditions. Extensive experiments were conducted at five Point of Interest (POI) locations under various light conditions with a total of 100 datasets. Descriptive statistic methods were employed to analyze the data and assess the performance variation. Additionally, the Analysis of Variance (ANOVA) analysis was utilized to assess the impact of different light conditions on the accuracy metric and horizontal tracking time, determining whether there are significant differences in performance across varying levels of light intensity. The experimental results revealed that a significant correlation (p < 0.05) exists between the ambient light intensity and the accuracy of the VSLAM/GSV integration approach. Through the confidence interval estimation, the minimum illuminance 434 lx is needed to provide a feasible and consistent accuracy. Variations in visual references, such as wet surfaces in the rainy season, also impact the horizontal tracking time and accuracy.
en-copyright=
kn-copyright=

en-aut-name=BrataKomang Candra
en-aut-sei=Brata
en-aut-mei=Komang Candra
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FunabikiNobuo
en-aut-sei=Funabiki
en-aut-mei=Nobuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=RiyantokoPrismahardi Aji
en-aut-sei=Riyantoko
en-aut-mei=Prismahardi Aji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=PandumanYohanes Yohanie Fridelin
en-aut-sei=Panduman
en-aut-mei=Yohanes Yohanie Fridelin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MentariMustika
en-aut-sei=Mentari
en-aut-mei=Mustika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=light intensity
kn-keyword=light intensity
en-keyword=Location-based Augmented Reality (LAR)
kn-keyword=Location-based Augmented Reality (LAR)
en-keyword=outdoor
kn-keyword=outdoor
en-keyword=Visual Simultaneous Localization And Mapping (VSLAM)
kn-keyword=Visual Simultaneous Localization And Mapping (VSLAM)
en-keyword=Google Street View (GSV)
kn-keyword=Google Street View (GSV)
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=
article-no=
start-page=98175
end-page=98188
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=2024
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Feasibility of Active Reactance Compensator for Autonomously Maximizing Repeater Coil Current of Wireless Power Transfer System Against Variations in Resonant Frequency and Magnetic Coupling Intensity
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In resonant inductive coupling wireless power transfer systems, a repeater resonator is crucial in expanding the charging area, enabling efficient power supply to receivers, such as small Internet of Things (IoT) devices sparsely distributed in a wide area. However, the repeater current is highly susceptible to deviations in resonance frequency due to manufacturing tolerance and aging, as well as to the magnetic coupling between the transmitter and repeater coils, potentially leading to insufficient amplitude. Consequently, the magnetic field generated by the repeater decreases and the receiver may be difficult to obtain sufficient power from the transmitter via the repeater. To address this problem, this paper proposes a wireless power transfer system with active reactance compensators incorporated in the repeater and the transmitter. The proposed system can equivalently adjust the resonant frequencies of the transmitter and repeater to stably maximize the repeater coil current regardless of the variations in the resonant frequency and the magnetic coupling intensity. Experiments successfully verify that the proposed system can provide a more stable and larger repeater current and output power than the conventional system against the variations in the magnetic field intensity and the resonant frequency of the repeater, validating the feasibility of the proposed system for practical utilization of the repeater in expanding the charging area.
en-copyright=
kn-copyright=

en-aut-name=IshiharaMasataka
en-aut-sei=Ishihara
en-aut-mei=Masataka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UmetaniKazuhiro
en-aut-sei=Umetani
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KonishiAkihiro
en-aut-sei=Konishi
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HirakiEiji
en-aut-sei=Hiraki
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Faculty of Life, Environment, Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Faculty of Life, Environment, Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Science and Engineering, Chiba University
kn-affil=

affil-num=4
en-affil=Faculty of Life, Environment, Natural Science and Technology, Okayama University
kn-affil=
en-keyword=Resonant inductive coupling
kn-keyword=Resonant inductive coupling
en-keyword=wireless power transfer
kn-keyword=wireless power transfer
en-keyword=repeater
kn-keyword=repeater
en-keyword=intermediate resonator
kn-keyword=intermediate resonator
en-keyword=frequency splitting phenomenon
kn-keyword=frequency splitting phenomenon
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=32
article-no=
start-page=12686
end-page=12694
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240710
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Boosting charge separation in organic photovoltaics: unveiling dipole moment variations in excited non-fullerene acceptor layers
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The power conversion efficiency (PCE) of organic photovoltaics (OPVs) has reached more than 19% due to the rapid development of non-fullerene acceptors (NFAs). To compete with the PCEs (26%) of commercialized silicon-based inorganic photovoltaics, the drawback of OPVs should be minimized. This drawback is the intrinsic large loss of open-circuit voltage; however, a general approach to this issue remains elusive. Here, we report a discovery regarding highly efficient NFAs, specifically ITIC. We found that charge-transfer (CT) and charge dissociation (CD) can occur even in a neat ITIC film without the donor layer. This is surprising, as these processes were previously believed to take place exclusively at donor/acceptor heterojunctions. Femtosecond time-resolved visible to mid-infrared measurements revealed that in the neat ITIC layers, the intermolecular CT immediately proceeds after photoirradiation (<0.1 ps) to form weakly-bound excitons with a binding energy of 0.3 eV, which are further dissociated into free electrons and holes with a time-constant of 56 ps. Theoretical calculations indicate that stacking faults in ITIC (i.e., V-type molecular stacking) induce instantaneous intermolecular CT and CD in the neat ITIC layer. In contrast, J-type stacking does not support such CT and CD. This previously unknown pathway is triggered by the larger dipole moment change on the excited state generated at the lower symmetric V-type molecular stacking of ITIC. This is in sharp contrast with the need of sufficient energy offset for CT and CD at the donor-acceptor heterojunction, leading to the significant voltage loss in conventional OPVs. These results demonstrate that the rational molecular design of NFAs can increase the local dipole moment change on the excited state within the NFA layer. This finding paves the way for a groundbreaking route toward the commercialization of OPVs.
en-copyright=
kn-copyright=

en-aut-name=YamakataAkira
en-aut-sei=Yamakata
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KatoKosaku
en-aut-sei=Kato
en-aut-mei=Kosaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=UrakamiTakumi
en-aut-sei=Urakami
en-aut-mei=Takumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TsujimuraSota
en-aut-sei=Tsujimura
en-aut-mei=Sota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MurayamaKasumi
en-aut-sei=Murayama
en-aut-mei=Kasumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HigashiMasahiro
en-aut-sei=Higashi
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SatoHirofumi
en-aut-sei=Sato
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KoboriYasuhiro
en-aut-sei=Kobori
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=UmeyamaTomokazu
en-aut-sei=Umeyama
en-aut-mei=Tomokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ImahoriHiroshi
en-aut-sei=Imahori
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Molecular Engineering, Graduate School of Engineering, Kyoto University
kn-affil=

affil-num=4
en-affil=Department of Chemistry, Graduate School of Science, Kobe University
kn-affil=

affil-num=5
en-affil=Department of Chemistry, Graduate School of Science, Kobe University
kn-affil=

affil-num=6
en-affil=Department of Complex Systems Science, Graduate School of Informatics, Nagoya University
kn-affil=

affil-num=7
en-affil=Department of Molecular Engineering, Graduate School of Engineering, Kyoto University
kn-affil=

affil-num=8
en-affil=Department of Chemistry, Graduate School of Science, Kobe University
kn-affil=

affil-num=9
en-affil=Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo
kn-affil=

affil-num=10
en-affil=Department of Molecular Engineering, Graduate School of Engineering, Kyoto University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=6
article-no=
start-page=24-00129
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=2024
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effect of artificial defect on tensile properties of thin titanium alloy wire
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study investigated the effects of artificial defects, introduced via focused ion beam (FIB) processing, on the tensile properties of thin titanium alloy wires (Ti-6Al-4V). Results indicated that the defective wires fractured when the net-section nominal stress reached the ultimate tensile strength of the smooth wires, probably because of localized stress concentrations relaxing due to plastic deformation around the defects. The effect of defects on tensile properties was classified into three regions based on the size of the defect area. In the case of small defects, wires fractured at the smooth area away from the defects where the cross-sectional strength was lower. In this case, the defects minimally affected the tensile properties. This is attributable to variations in the cross-sectional strength of the wire, which resulted in some sections with lower strength as compared with the defect area. In the case of medium-sized defects, the fracture strain decreased gradually as the defect area increased. Finally, in the case of large defects, the fracture strain was extremely small. The boundary between the medium-sized and large defects indicates the transition from plastic deformation to no plastic deformation in the smooth area.
en-copyright=
kn-copyright=

en-aut-name=SAKAMOTOJunji
en-aut-sei=SAKAMOTO
en-aut-mei=Junji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TADANaoya
en-aut-sei=TADA
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=UEMORITakeshi
en-aut-sei=UEMORI
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OISHIKoyo
en-aut-sei=OISHI
en-aut-mei=Koyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Okayama University
kn-affil=

affil-num=2
en-affil=Okayama University
kn-affil=

affil-num=3
en-affil=Okayama University
kn-affil=

affil-num=4
en-affil=Okayama University
kn-affil=
en-keyword=Ti-6Al-4V
kn-keyword=Ti-6Al-4V
en-keyword=Thin wire
kn-keyword=Thin wire
en-keyword=Tensile properties
kn-keyword=Tensile properties
en-keyword=Defect
kn-keyword=Defect
en-keyword=Focused ion beam
kn-keyword=Focused ion beam
en-keyword=Net-section nominal stress
kn-keyword=Net-section nominal stress
en-keyword=Fracture surface
kn-keyword=Fracture surface
en-keyword=Fracture strain
kn-keyword=Fracture strain
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=19
article-no=
start-page=21287
end-page=21297
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240501
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Superstructure of Fe5?xGeTe2 Determined by Te K-Edge Extended X-ray Absorption Fine Structure and Te Kα X-ray Fluorescence Holography
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The local structure of the two-dimensional van der Waals material, Fe5?xGeTe2, which exhibits unique structural/magnetic phase transitions, was investigated by Te K-edge extended X-ray absorption fine structure (EXAFS) and Te Kα X-ray fluorescence holography (XFH) over a wide temperature range. The formation of a trimer of Te atoms at low temperatures has been fully explored using these methods. An increase in the Te?Fe distance at approximately 150 K was suggested by EXAFS and presumably indicates the formation of a Te trimer. Moreover, XFH displayed clear atomic images of Te atoms. Additionally, the distance between the Te atoms shortened, as confirmed from the atomic images reconstructed from XFH, indicating the formation of a trimer of Te atoms, i.e., a charge-ordered (3??√×3??√)?30? superstructure. Furthermore, Te Kα XFH provided unambiguous atomic images of Fe atoms occupying the Fe1 site; the images were not clearly observed in the Ge Kα XFH that was previously reported because of the low occupancy of Fe and Ge atoms. In this study, EXAFS and XFH clearly showed the local structure around the Te atom; in particular, the formation of Te trimers caused by charge-ordered phase transitions was clearly confirmed. The charge-ordered phase transition is fully discussed based on the structural variation at low temperatures, as established from EXAFS and XFH.
en-copyright=
kn-copyright=

en-aut-name=EguchiRitsuko
en-aut-sei=Eguchi
en-aut-mei=Ritsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SekharHalubai
en-aut-sei=Sekhar
en-aut-mei=Halubai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KimuraKoji
en-aut-sei=Kimura
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MasaiHirokazu
en-aut-sei=Masai
en-aut-mei=Hirokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HappoNaohisa
en-aut-sei=Happo
en-aut-mei=Naohisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IkedaMitsuki
en-aut-sei=Ikeda
en-aut-mei=Mitsuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YamamotoYuki
en-aut-sei=Yamamoto
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=UtsumiMasaki
en-aut-sei=Utsumi
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=GotoHidenori
en-aut-sei=Goto
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TakabayashiYasuhiro
en-aut-sei=Takabayashi
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=TajiriHiroo
en-aut-sei=Tajiri
en-aut-mei=Hiroo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=HayashiKoichi
en-aut-sei=Hayashi
en-aut-mei=Koichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KubozonoYoshihiro
en-aut-sei=Kubozono
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Physical Science and Technology, Nagoya Institute of Technology
kn-affil=

affil-num=3
en-affil=Department of Physical Science and Technology, Nagoya Institute of Technology
kn-affil=

affil-num=4
en-affil=Department of Materials and Chemistry, National Institute of Advanced Industrial Science and Technology (AIST)
kn-affil=

affil-num=5
en-affil=Graduate School of Information Sciences, Hiroshima City University
kn-affil=

affil-num=6
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=7
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=8
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=9
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Physical Science and Technology, Nagoya Institute of Technology
kn-affil=

affil-num=11
en-affil=Japan Synchrotron Radiation Research Institute (JASRI)
kn-affil=

affil-num=12
en-affil=Department of Physical Science and Technology, Nagoya Institute of Technology
kn-affil=

affil-num=13
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=9
article-no=
start-page=094001
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230914
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Active control of localized mode and transmission in topological phononic waveguides by non-Hermitian modulation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We demonstrate the switching behavioral differences between lossy and nearly lossless edge-mode propagation by non-Hermitian modulation based on the phononic band design of a C3v symmetric, two-dimensional phononic crystal with a unit cell composed of three air-filled circular holes in polydimethylsiloxane. We numerically show that strong loss effects lead to the extinction of the localized modes. This mechanism is analogous to the bound-to-unbound transition in non-Hermitian quantum systems. This result suggests that large variations in non-Hermitian modulation can be used for the active control of edge-mode propagation along topological interfaces.
en-copyright=
kn-copyright=

en-aut-name=AliMd. Shuzon
en-aut-sei=Ali
en-aut-mei=Md. Shuzon
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HataYusuke
en-aut-sei=Hata
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TsurutaKenji
en-aut-sei=Tsuruta
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Electrical and Electronic Engineering, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Electrical and Electronic Engineering, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Electrical and Electronic Engineering, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=7
article-no=
start-page=85
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202307
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Latitudinal cline in reproductive traits in the red flour beetle Tribolium castaneum
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Several previous studies have reported geographic variation and/or latitudinal clines of morphological sexual characteristics, but there are few studies that consider reproductive traits that are not morphological. Here, we measured the proportion of females fertilized by males, frequency of reproductive failure in males, and number of female copulations of the red flour beetle Tribolium castaneum collected from fields in Japan to investigate the relationship between reproductive traits and latitude. Our results show substantial differences in the reproductive traits of both sexes among field populations. We identified latitudinal clines for reproductive traits in males, but not females. Moreover, female, but not male, reproductive traits were correlated with body size. Our study suggests that selection for male reproductive traits varies with latitude in T. castaneum.
en-copyright=
kn-copyright=

en-aut-name=MatsumuraKentarou
en-aut-sei=Matsumura
en-aut-mei=Kentarou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WakabayashiKyosuke
en-aut-sei=Wakabayashi
en-aut-mei=Kyosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KawakamiRenya
en-aut-sei=Kawakami
en-aut-mei=Renya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MiyatakeTakahisa
en-aut-sei=Miyatake
en-aut-mei=Takahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Environmental, Life Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental, Life Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Faculty of Agriculture, Kagawa University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental, Life Science and Technology, Okayama University
kn-affil=
en-keyword=Sexual selection
kn-keyword=Sexual selection
en-keyword=Sexual conflict
kn-keyword=Sexual conflict
en-keyword=Geographic variation
kn-keyword=Geographic variation
en-keyword=Tribolium castaneum
kn-keyword=Tribolium castaneum
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=3
article-no=
start-page=34
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240224
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Experimental quantification of genetic and ontogenetic effects on fighting behavior in the broad-horned flour beetle
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Most animal behaviors show large within- and among-individual variation, and this includes competitive male behaviors. With male fighting for example, aggressiveness often correlates with dominance, and contest duration varies with age. However, few studies have directly quantified how mean aggressiveness and contest duration, the variation among individuals in both traits, and the relationship among them, vary with age. Here we address these gaps and examine the effect of male age and genotype on two key aspects of male fighting behavior - aggressiveness (here measured as latency to fight) and contest duration - and the relationship between them. We do this using isogenic lines of the broad-horned flour beetle Gnatocerus cornutus. We observed fighting behavior of paired males of similar body size and age. Using uni- and multivariate mixed models, we show that although there was a significant difference between younger and older males in contest duration, mean aggressiveness was not affected by male age. However, the variation in aggression and fight duration varied with age, being greater in younger and older males respectively. Additionally, although there was a positive correlation between aggressiveness and contest duration in younger males, this relationship was not found in older males. Finally, the only significant genetic effect was for aggression in younger males. Our study shows that age differentially shapes key components of male fighting behavior as well as the relationship among them, highlighting the dynamic nature and context-dependence of fighting.
en-copyright=
kn-copyright=

en-aut-name=NishitaniToshiki
en-aut-sei=Nishitani
en-aut-mei=Toshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsumuraKentarou
en-aut-sei=Matsumura
en-aut-mei=Kentarou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=PostmaErik
en-aut-sei=Postma
en-aut-mei=Erik
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SharmaManmohan Dev
en-aut-sei=Sharma
en-aut-mei=Manmohan Dev
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HoskenDavid J
en-aut-sei=Hosken
en-aut-mei=David J
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MiyatakeTakahisa
en-aut-sei=Miyatake
en-aut-mei=Takahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Environmental, Life, Natural and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental, Life, Natural and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Centre for Ecology & Conservation, University of Exeter, Penryn Campus
kn-affil=

affil-num=4
en-affil=Centre for Ecology & Conservation, University of Exeter, Penryn Campus
kn-affil=

affil-num=5
en-affil=Centre for Ecology & Conservation, University of Exeter, Penryn Campus
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental, Life, Natural and Technology, Okayama University
kn-affil=
en-keyword=Male-male contest
kn-keyword=Male-male contest
en-keyword=Contest
kn-keyword=Contest
en-keyword=Aggressiveness
kn-keyword=Aggressiveness
en-keyword=Aging
kn-keyword=Aging
en-keyword=Genetics
kn-keyword=Genetics
en-keyword=Beetle
kn-keyword=Beetle
END

start-ver=1.4
cd-journal=joma
no-vol=299
cd-vols=
no-issue=8
article-no=
start-page=105020
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Mammalian type opsin 5 preferentially activates G14 in Gq-type G proteins triggering intracellular calcium response
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Mammalian type opsin 5 (Opn5m), a UV-sensitive G protein-coupled receptor opsin highly conserved in vertebrates, would provide a common basis for UV sensing from lamprey to humans. However, G protein coupled with Opn5m remains controversial due to variations in assay conditions and the origin of Opn5m across different reports. Here, we examined Opn5m from diverse species using an aequorin luminescence assay and G alpha-KO cell line. Beyond the commonly studied major G alpha classes, G alpha q, G alpha 11, G alpha 14, and G alpha 15 in the Gq class were individually investigated in this study, as they can drive distinct signaling pathways in addition to a canonical calcium response. UV light triggered a calcium response via all the tested Opn5m proteins in 293T cells, which was abolished by Gq-type G alpha deletion and rescued by cotransfection with mouse and medaka Gq-type G alpha proteins. Opn5m preferentially activated G alpha 14 and close relatives. Mutational analysis implicated specific regions, including alpha 3-beta 5 and alpha G-alpha 4 loops, alpha G and alpha 4 helices, and the extreme C terminus, in the preferential activation of G alpha 14 by Opn5m. FISH revealed co-expression of genes encoding Opn5m and G alpha 14 in the scleral cartilage of medaka and chicken eyes, supporting their physiological coupling. This suggests that the preferential activation of G alpha 14 by Opn5m is relevant for UV sensing in specific cell types.
en-copyright=
kn-copyright=

en-aut-name=SatoKeita
en-aut-sei=Sato
en-aut-mei=Keita
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamashitaTakahiro
en-aut-sei=Yamashita
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OhuchiHideyo
en-aut-sei=Ohuchi
en-aut-mei=Hideyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Cytology and Histology, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Biophysics, Graduate School of Science, Kyoto University
kn-affil=

affil-num=3
en-affil=Department of Cytology and Histology, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=G protein
kn-keyword=G protein
en-keyword=G protein?coupled receptor (GPCR)
kn-keyword=G protein?coupled receptor (GPCR)
en-keyword=photoreceptor
kn-keyword=photoreceptor
en-keyword=rhodopsin
kn-keyword=rhodopsin
en-keyword=calcium intracellular release
kn-keyword=calcium intracellular release
en-keyword=protein?protein interaction
kn-keyword=protein?protein interaction
en-keyword=signal transduction
kn-keyword=signal transduction
en-keyword=nonvisual photoreception
kn-keyword=nonvisual photoreception
END

start-ver=1.4
cd-journal=joma
no-vol=18
cd-vols=
no-issue=6
article-no=
start-page=4993
end-page=5002
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Spatially Uniform and Quantitative Surface-Enhanced Raman Scattering under Modal Ultrastrong Coupling Beyond Nanostructure Homogeneity Limits
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We developed a substrate that enables highly sensitive and spatially uniform surface-enhanced Raman scattering (SERS). This substrate comprises densely packed gold nanoparticles (d-AuNPs)/titanium dioxide/Au film (d-ATA). The d-ATA substrate demonstrates modal ultrastrong coupling between localized surface plasmon resonances (LSPRs) of AuNPs and Fabry?P?rot nanocavities. d-ATA exhibits a significant enhancement of the near-field intensity, resulting in a 78-fold increase in the SERS signal for crystal violet (CV) compared to that of d-AuNP/TiO2 substrates. Importantly, high sensitivity and a spatially uniform signal intensity can be obtained without precise control of the shape and arrangement of the nanoscale AuNPs, enabling quantitative SERS measurements. Additionally, SERS measurements of rhodamine 6G (R6G) on this substrate under ultralow adsorption conditions (0.6 R6G molecules/AuNP) show a spatial variation in the signal intensity within 3%. These findings suggest that the SERS signal under modal ultrastrong coupling originates from multiple plasmonic particles with quantum coherence.
en-copyright=
kn-copyright=

en-aut-name=SuganamiYoshiki
en-aut-sei=Suganami
en-aut-mei=Yoshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OshikiriTomoya
en-aut-sei=Oshikiri
en-aut-mei=Tomoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MitomoHideyuki
en-aut-sei=Mitomo
en-aut-mei=Hideyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SasakiKeiji
en-aut-sei=Sasaki
en-aut-mei=Keiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=LiuYen-En
en-aut-sei=Liu
en-aut-mei=Yen-En
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ShiXu
en-aut-sei=Shi
en-aut-mei=Xu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MatsuoYasutaka
en-aut-sei=Matsuo
en-aut-mei=Yasutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IjiroKuniharu
en-aut-sei=Ijiro
en-aut-mei=Kuniharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MisawaHiroaki
en-aut-sei=Misawa
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Research Institute for Electronic Science, Hokkaido University
kn-affil=

affil-num=2
en-affil=Research Institute for Electronic Science, Hokkaido University
kn-affil=

affil-num=3
en-affil=Research Institute for Electronic Science, Hokkaido University
kn-affil=

affil-num=4
en-affil=Research Institute for Electronic Science, Hokkaido University
kn-affil=

affil-num=5
en-affil=Research Institute for Electronic Science, Hokkaido University
kn-affil=

affil-num=6
en-affil=Creative Research Institution, Hokkaido University
kn-affil=

affil-num=7
en-affil=Research Institute for Electronic Science, Hokkaido University
kn-affil=

affil-num=8
en-affil=Research Institute for Electronic Science, Hokkaido University
kn-affil=

affil-num=9
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=
en-keyword=localized surface plasmon resonance
kn-keyword=localized surface plasmon resonance
en-keyword=modalultrastrongcoupling
kn-keyword=modalultrastrongcoupling
en-keyword=surface-enhanced Raman scattering
kn-keyword=surface-enhanced Raman scattering
en-keyword=quantumcoherence
kn-keyword=quantumcoherence
en-keyword=self-assembly
kn-keyword=self-assembly
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=548
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240115
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Ultrathin Platinum Film Hydrogen Sensors with a Twin-T Type Notch Filter Circuit
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In recent years, hydrogen energy has garnered attention as a potential solution for mitigating greenhouse gas emissions. However, concerns regarding the inherent risk of hydrogen gas leakage and potential explosions have necessitated the development of advanced sensors. Within our research group, we have innovated an ultrathin platinum (Pt) film hydrogen sensor that gauges resistance changes in Pt thin films when exposed to hydrogen gas. Notably, the sensitivity of each sensor is contingent upon the thickness of the Pt film. To address the challenge of detecting hydrogen using multiple sensors, we integrated the ultrathin Pt film as a resistance element within a twin-T type notch filter. This filter exhibits a distinctive reduction in output signals at a specific frequency. The frequency properties of the notch filter dynamically alter with changes in the resistance of the Pt film induced by hydrogen exposure. Consequently, the ultrathin Pt film hydrogen sensor monitors output signal variations around the notch frequency, responding to shifts in frequency properties. This innovative approach enables the electrical control of sensor sensitivity by adjusting the operating frequency in proximity to the notch frequency. Additionally, the simultaneous detection of hydrogen by multiple sensors was successfully achieved by interconnecting sensors with distinct notch frequencies in series.
en-copyright=
kn-copyright=

en-aut-name=WakabayashiShoki
en-aut-sei=Wakabayashi
en-aut-mei=Shoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhYuki
en-aut-sei=Oh
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakayamaHaruhito
en-aut-sei=Nakayama
en-aut-mei=Haruhito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=WangJin
en-aut-sei=Wang
en-aut-mei=Jin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KiwaToshihiko
en-aut-sei=Kiwa
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=hydrogen sensor
kn-keyword=hydrogen sensor
en-keyword=ultrathin film
kn-keyword=ultrathin film
en-keyword=twin-T
kn-keyword=twin-T
en-keyword=notch filter
kn-keyword=notch filter
en-keyword=platinum
kn-keyword=platinum
END

start-ver=1.4
cd-journal=joma
no-vol=20
cd-vols=
no-issue=7
article-no=
start-page=1611
end-page=1619
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240118
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Controlled mechanical properties of poly(ionic liquid)-based hydrophobic ion gels by the introduction of alumina nanoparticles with different shapes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Ionic?liquid gels, also known as ion gels, have gained considerable attention due to their high ionic conductivity and CO2 absorption capacity. However, their low mechanical strength has hindered their practical applications. A potential solution to this challenge is the incorporation of particles, such as silica nanoparticles, TiO2 nanoparticles, and metal?organic frameworks (MOFs) into ion gels. Comparative studies on the effect of particles with different shapes are still in progress. This study investigated the effect of the shape of particles introduced into ion gels on their mechanical properties. Consequently, alumina/poly(ionic liquid) (PIL) double-network (DN) ion gels consisting of clustered alumina nanoparticles with various shapes (either spherical or rod-shaped) and a chemically crosslinked poly[1-ethyl-3-vinylimidazolium bis(trifluoromethanesulfonyl)imide] (PC2im-TFSI, PIL) network were prepared. The results revealed that the mechanical strengths of the alumina/PIL DN ion gels were superior to those of PIL single-network ion gels without particles. Notably, the fracture energies of the rod-shaped alumina/PIL DN ion gels were approximately 2.6 times higher than those of the spherical alumina/PIL DN ion gels. Cyclic tensile tests were performed, and the results indicate that the loading energy on the ion gel was dissipated through the fracture of the alumina network. TEM observation suggests that the variation in the mechanical strength depending on the shape can be attributed to differences in the aggregation structure of the alumina particles, thus indicating the possibility of tuning the mechanical strength of ion gels by altering not only particle kinds but its shape.
en-copyright=
kn-copyright=

en-aut-name=MizutaniYuna
en-aut-sei=Mizutani
en-aut-mei=Yuna
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=LopezCarlos G.
en-aut-sei=Lopez
en-aut-mei=Carlos G.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Materials Science and Engineering, The Pennsylvania State University
kn-affil=

affil-num=4
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=113
cd-vols=
no-issue=
article-no=
start-page=41
end-page=48
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Instant estimation of rice yield using ground-based RGB images and its potential applicability to UAV
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Rice (Oryza sativa L.) is one of the most important cereals, which provides 20% of the world’s food energy. However, its productivity is poorly assessed especially in the global South. Here, we provide a first study to perform a deep learning-based approach for instantaneously estimating rice yield using RGB images. During ripening stage and at harvest, over 22,000 digital images were captured vertically downwards over the rice canopy from a distance of 0.8 to 0.9m at 4,820 harvesting plots having the yield of 0.1 to 16.1 t ha-1 across six countries in Africa and Japan. A convolutional neural network (CNN) applied to these data at harvest predicted 68% variation in yield with a relative root mean square error (rRMSE) of 0.22. Even when the resolution of images was reduced (from 0.2 to 3.2cm pixel-1 of ground sampling distance), the model could predict 57% variation in yield, implying that this approach can be scaled by use of unmanned aerial vehicles. Our work offers low-cost, hands-on, and rapid approach for high throughput phenotyping, and can lead to impact assessment of productivity-enhancing interventions, detection of fields where these are needed to sustainably increase crop production.
en-copyright=
kn-copyright=

en-aut-name=TanakaYu
en-aut-sei=Tanaka
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WatanabeTomoya
en-aut-sei=Watanabe
en-aut-mei=Tomoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KatsuraKeisuke
en-aut-sei=Katsura
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TsujimotoYasuhiro
en-aut-sei=Tsujimoto
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakaiToshiyuki
en-aut-sei=Takai
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TanakaTakashi Sonam Tashi
en-aut-sei=Tanaka
en-aut-mei=Takashi Sonam Tashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KawamuraKensuke
en-aut-sei=Kawamura
en-aut-mei=Kensuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SaitoHiroki
en-aut-sei=Saito
en-aut-mei=Hiroki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=HommaKoki
en-aut-sei=Homma
en-aut-mei=Koki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MairouaSalifou Goube
en-aut-sei=Mairoua
en-aut-mei=Salifou Goube
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=AhouantonKokou
en-aut-sei=Ahouanton
en-aut-mei=Kokou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=IbrahimAli
en-aut-sei=Ibrahim
en-aut-mei=Ali
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=SenthilkumarKalimuthu
en-aut-sei=Senthilkumar
en-aut-mei=Kalimuthu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=SemwalVimal Kumar
en-aut-sei=Semwal
en-aut-mei=Vimal Kumar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=MatuteEduardo Jose Graterol
en-aut-sei=Matute
en-aut-mei=Eduardo Jose Graterol
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=CorredorEdgar
en-aut-sei=Corredor
en-aut-mei=Edgar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=El-NamakyRaafat
en-aut-sei=El-Namaky
en-aut-mei=Raafat
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=ManigbasNorvie
en-aut-sei=Manigbas
en-aut-mei=Norvie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=QuilangEduardo Jimmy P.
en-aut-sei=Quilang
en-aut-mei=Eduardo Jimmy P.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=IwahashiYu
en-aut-sei=Iwahashi
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=NakajimaKota
en-aut-sei=Nakajima
en-aut-mei=Kota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=TakeuchiEisuke
en-aut-sei=Takeuchi
en-aut-mei=Eisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=SaitoKazuki
en-aut-sei=Saito
en-aut-mei=Kazuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

affil-num=1
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Mathematics, Kyushu University
kn-affil=

affil-num=3
en-affil=Graduate School of Agriculture, Tokyo University of Agriculture and Technology
kn-affil=

affil-num=4
en-affil=Japan International Research Center for Agricultural Sciences
kn-affil=

affil-num=5
en-affil=Japan International Research Center for Agricultural Sciences
kn-affil=

affil-num=6
en-affil=Faculty of Biological Sciences, Gifu UniversityFaculty of Biological Sciences, Gifu University
kn-affil=

affil-num=7
en-affil=Japan International Research Center for Agricultural Sciences
kn-affil=

affil-num=8
en-affil=Tropical Agriculture Research Front, Japan International Research Center for Agricultural Sciences
kn-affil=

affil-num=9
en-affil=Graduate School of Agricultural Science, Tohoku University
kn-affil=

affil-num=10
en-affil=Africa Rice Center （AfricaRice）
kn-affil=

affil-num=11
en-affil=Africa Rice Center （AfricaRice）
kn-affil=

affil-num=12
en-affil=Africa Rice Center （AfricaRice）, Regional Station for the Sahel
kn-affil=

affil-num=13
en-affil=Africa Rice Center （AfricaRice）
kn-affil=

affil-num=14
en-affil=Africa Rice Center （AfricaRice）, Nigeria Station
kn-affil=

affil-num=15
en-affil=Latin American Fund for Irrigated Rice - The Alliance of Bioversity International and CIAT
kn-affil=

affil-num=16
en-affil=Latin American Fund for Irrigated Rice - The Alliance of Bioversity International and CIAT
kn-affil=

affil-num=17
en-affil=Rice Research and Training Center, Field Crops Research Institute
kn-affil=

affil-num=18
en-affil=Philippine Rice Research Institute （PhilRice）
kn-affil=

affil-num=19
en-affil=Philippine Rice Research Institute （PhilRice）
kn-affil=

affil-num=20
en-affil=Graduate School of Agriculture, Kyoto University
kn-affil=

affil-num=21
en-affil=Graduate School of Agriculture, Kyoto University
kn-affil=

affil-num=22
en-affil=Graduate School of Agriculture, Kyoto University
kn-affil=

affil-num=23
en-affil=Japan International Research Center for Agricultural Sciences
kn-affil=
en-keyword=Rice (Oryza sativa L.)
kn-keyword=Rice (Oryza sativa L.)
en-keyword=rough grain yield
kn-keyword=rough grain yield
en-keyword=convolutional neural network
kn-keyword=convolutional neural network
en-keyword=RGB images
kn-keyword=RGB images
en-keyword=UAV
kn-keyword=UAV
END

start-ver=1.4
cd-journal=joma
no-vol=189
cd-vols=
no-issue=1
article-no=
start-page=8
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240117
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Trends in the Incidence of Disseminated Cryptococcosis in Japan: A Nationwide Observational Study, 2015?2021
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background Cryptococcus species can cause severe disseminated infections in immunocompromised hosts. This study investigated the epidemiological features and trends in disseminated cryptococcosis in Japan.<br>
Methods We used publicly available Infectious Diseases Weekly Reports to obtain data on the incidence of disseminated cryptococcosis in Japan from 2015 to 2021. Patient information, including age, sex, and regional and seasonal data, were extracted. The Joinpoint regression program was used to determine the age-adjusted incidence rate (AAR) per 100,000 population, annual percentage change (APC), and average APC (AAPC).<br>
Results A total of 1047 cases of disseminated cryptococcosis were reported, of which those aged???70 years accounted for 68.8%. The AAR in men was significantly higher than that in women (median: 0.13 vs. 0.09: p?=?0.0024). APC for the overall cases increased by 9.9% (95% confidence interval [95% CI]???5.4?27.7) from 2015 to 2018 and then decreased by?3.3% (95% CI???15.5?10.7) from 2018 to 2021. AAPC for the entire study period was 3.1% (95% CI???1.5?8.0), indicating a possible increase in its number, although not statistically significant. In terms of regional distribution, the average AAR was highest in Shikoku District (0.17) and lowest in Hokkaido District (0.04). Northern Japan exhibited a significantly lower median AAR (median [interquartile range]: 0.06 [0.05, 0.08]) than the Eastern (0.12 [0.12, 0.13]), Western (0.11 [0.10, 0.13]), and Southern (0.14 [0.12, 0.15]) regions. No seasonal variation in incidence was observed.<br>
Conclusion The prevalence of disseminated cryptococcosis has not increased in Japan. Geographically, the incidence is lower in Northern Japan. Further investigations that incorporate detailed clinical data are required.
en-copyright=
kn-copyright=

en-aut-name=AkazawaHidemasa
en-aut-sei=Akazawa
en-aut-mei=Hidemasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HagiyaHideharu
en-aut-sei=Hagiya
en-aut-mei=Hideharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KoyamaToshihiro
en-aut-sei=Koyama
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Infectious Diseases, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Health Data Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Disseminated cryptococcosis
kn-keyword=Disseminated cryptococcosis
en-keyword=Cryptococcal infection
kn-keyword=Cryptococcal infection
en-keyword=Epidemiology
kn-keyword=Epidemiology
en-keyword=Trend analysis
kn-keyword=Trend analysis
en-keyword=Regionality
kn-keyword=Regionality
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=
article-no=
start-page=0073
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230728
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Deep Learning Enables Instant and Versatile Estimation of Rice Yield Using Ground-Based RGB Images
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Rice (Oryza sativa L.) is one of the most important cereals, which provides 20% of the world’s food energy. However, its productivity is poorly assessed especially in the global South. Here, we provide a first study to perform a deep-learning-based approach for instantaneously estimating rice yield using red-green-blue images. During ripening stage and at harvest, over 22,000 digital images were captured vertically downward over the rice canopy from a distance of 0.8 to 0.9 m at 4,820 harvesting plots having the yield of 0.1 to 16.1 t?ha?1 across 6 countries in Africa and Japan. A convolutional neural network applied to these data at harvest predicted 68% variation in yield with a relative root mean square error of 0.22. The developed model successfully detected genotypic difference and impact of agronomic interventions on yield in the independent dataset. The model also demonstrated robustness against the images acquired at different shooting angles up to 30° from right angle, diverse light environments, and shooting date during late ripening stage. Even when the resolution of images was reduced (from 0.2 to 3.2 cm?pixel?1 of ground sampling distance), the model could predict 57% variation in yield, implying that this approach can be scaled by the use of unmanned aerial vehicles. Our work offers low-cost, hands-on, and rapid approach for high-throughput phenotyping and can lead to impact assessment of productivity-enhancing interventions, detection of fields where these are needed to sustainably increase crop production, and yield forecast at several weeks before harvesting.
en-copyright=
kn-copyright=

en-aut-name=TanakaYu
en-aut-sei=Tanaka
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WatanabeTomoya
en-aut-sei=Watanabe
en-aut-mei=Tomoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KatsuraKeisuke
en-aut-sei=Katsura
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TsujimotoYasuhiro
en-aut-sei=Tsujimoto
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakaiToshiyuki
en-aut-sei=Takai
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TanakaTakashi Sonam Tashi
en-aut-sei=Tanaka
en-aut-mei=Takashi Sonam Tashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KawamuraKensuke
en-aut-sei=Kawamura
en-aut-mei=Kensuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SaitoHiroki
en-aut-sei=Saito
en-aut-mei=Hiroki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=HommaKoki
en-aut-sei=Homma
en-aut-mei=Koki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MairouaSalifou Goube
en-aut-sei=Mairoua
en-aut-mei=Salifou Goube
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=AhouantonKokou
en-aut-sei=Ahouanton
en-aut-mei=Kokou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=IbrahimAli
en-aut-sei=Ibrahim
en-aut-mei=Ali
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=SenthilkumarKalimuthu
en-aut-sei=Senthilkumar
en-aut-mei=Kalimuthu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=SemwalVimal Kumar
en-aut-sei=Semwal
en-aut-mei=Vimal Kumar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=MatuteEduardo Jose Graterol
en-aut-sei=Matute
en-aut-mei=Eduardo Jose Graterol
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=CorredorEdgar
en-aut-sei=Corredor
en-aut-mei=Edgar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=El-NamakyRaafat
en-aut-sei=El-Namaky
en-aut-mei=Raafat
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=ManigbasNorvie
en-aut-sei=Manigbas
en-aut-mei=Norvie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=QuilangEduardo Jimmy P.
en-aut-sei=Quilang
en-aut-mei=Eduardo Jimmy P.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=IwahashiYu
en-aut-sei=Iwahashi
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=NakajimaKota
en-aut-sei=Nakajima
en-aut-mei=Kota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=TakeuchiEisuke
en-aut-sei=Takeuchi
en-aut-mei=Eisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=SaitoKazuki
en-aut-sei=Saito
en-aut-mei=Kazuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

affil-num=1
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Mathematics, Kyushu University
kn-affil=

affil-num=3
en-affil=Graduate School of Agriculture, Tokyo University of Agriculture and Technology
kn-affil=

affil-num=4
en-affil=Japan International Research Center for Agricultural Sciences
kn-affil=

affil-num=5
en-affil=Japan International Research Center for Agricultural Sciences
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=7
en-affil=Japan International Research Center for Agricultural Sciences
kn-affil=

affil-num=8
en-affil=Tropical Agriculture Research Front, Japan International Research Center for Agricultural Sciences
kn-affil=

affil-num=9
en-affil=Graduate School of Agricultural Science, Tohoku University
kn-affil=

affil-num=10
en-affil=Africa Rice Center (AfricaRice)
kn-affil=

affil-num=11
en-affil=Africa Rice Center (AfricaRice)
kn-affil=

affil-num=12
en-affil=Africa Rice Center (AfricaRice), Regional Station for the Sahel
kn-affil=

affil-num=13
en-affil=Africa Rice Center (AfricaRice)
kn-affil=

affil-num=14
en-affil=Africa Rice Center (AfricaRice), Nigeria Station
kn-affil=

affil-num=15
en-affil=Latin American Fund for Irrigated Rice - The Alliance of Bioversity International and CIAT
kn-affil=

affil-num=16
en-affil=Latin American Fund for Irrigated Rice - The Alliance of Bioversity International and CIAT
kn-affil=

affil-num=17
en-affil=Rice Research and Training Center, Field Crops Research Institute, ARC
kn-affil=

affil-num=18
en-affil=Philippine Rice Research Institute (PhilRice)
kn-affil=

affil-num=19
en-affil=Philippine Rice Research Institute (PhilRice)
kn-affil=

affil-num=20
en-affil=Graduate School of Agriculture, Kyoto University
kn-affil=

affil-num=21
en-affil=Graduate School of Agriculture, Kyoto University
kn-affil=

affil-num=22
en-affil=Graduate School of Agriculture, Kyoto University
kn-affil=

affil-num=23
en-affil=Graduate School of Agriculture, Kyoto University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=
article-no=
start-page=101854
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202312
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The long-run risk premium in the intertemporal CAPM: International evidence
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study investigates whether long-run conditional covariance risk is linked to expected returns in the Intertemporal CAPM framework. We observe that the long-run value risk is positively associated with the expected returns on the global portfolios excluding the US. We also find that the long-run momentum risk is negatively related to the expected returns. In contrast, the long-run market risk is not associated with them, due to the low covariance variation across portfolios. Finally, we uncover that the long-run value premiums were strong for the global and European portfolios before the COVID-19 pandemic.
en-copyright=
kn-copyright=

en-aut-name=SakemotoRyuta
en-aut-sei=Sakemoto
en-aut-mei=Ryuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Okayama University, Okayama-ken, Japan and Keio Economic Observatory, Keio University
kn-affil=
en-keyword=ICAPM
kn-keyword=ICAPM
en-keyword=long-run risk
kn-keyword=long-run risk
en-keyword=value anomalies
kn-keyword=value anomalies
en-keyword=factor models
kn-keyword=factor models
en-keyword=COVID-19
kn-keyword=COVID-19
en-keyword=DCC-MIDAS
kn-keyword=DCC-MIDAS
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=80
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20231004
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Radiation in an emergency situation: attempting to respect the patient's beliefs as reported by a minor
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background　Each individual's unique health-related beliefs can greatly impact the patient-clinician relationship. When there is a conflict between the patient's preferences and recommended medical care, it can create a serious ethical dilemma, especially in an emergency setting, and dramatically alter this important relationship.<br>
Case presentation　A 56-year-old man, who remained comatose after out-of-hospital cardiac arrest, was rushed to our hospital. The patient was scheduled for emergency coronary angiography when his adolescent daughter reported that she and her father held sincere beliefs against radiation exposure. We were concerned that she did not fully understand the potential consequences if her father did not receive the recommended treatment. A physician provided her with in depth information regarding the risks and benefits of the treatment. While we did not want to disregard her statement, we opted to save the patient's life due to concerns about the validity of her report.<br>
Conclusions　Variations in beliefs regarding medical care force clinicians to incorporate patient beliefs into medical practice. However, an emergency may require a completely different approach. When faced with a patient in a life-threatening condition and unconscious, we should take action to prioritize saving their life, unless we are highly certain about the validity of their advance directives.
en-copyright=
kn-copyright=

en-aut-name=YumotoTetsuya
en-aut-sei=Yumoto
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HongoTakashi
en-aut-sei=Hongo
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KoideYasuhiro
en-aut-sei=Koide
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ObaraTakafumi
en-aut-sei=Obara
en-aut-mei=Takafumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TsukaharaKohei
en-aut-sei=Tsukahara
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NaitoHiromichi
en-aut-sei=Naito
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakaoAtsunori
en-aut-sei=Nakao
en-aut-mei=Atsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Emergency service
kn-keyword=Emergency service
en-keyword=Informed consent
kn-keyword=Informed consent
en-keyword=Radiation
kn-keyword=Radiation
en-keyword=Treatment refusal
kn-keyword=Treatment refusal
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=5
article-no=
start-page=499
end-page=509
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Neurological Analysis Based on the Terminal End of the Spinal Cord and the Narrowest Level of Injured Spine in Thoracolumbar Spinal Injuries
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study aimed to clarify neurological differences among the epiconus, conus medullaris, and cauda equina syndromes. Eighty-seven patients who underwent surgery for acute thoracolumbar spinal injuries were assessed. We defined the epiconus as the region from the terminal end of the spinal cord to the proximal 1.0 to 2.25 vertebral bodies, the conus medullaris as the region proximal to < 1.0 vertebral bodies, and the cauda equina as the distal part of the nerve roots originating from the spinal cord. On the basis of the distance from the terminal end of the spinal cord to the narrowest level of the spinal canal, the narrowest levels were ordered as follows: the epiconus followed by the conus medullaris and cauda equina. The narrowest levels were the epiconus in 22 patients, conus medullaris in 37 patients, and cauda equina in 25 patients. On admission, significantly more patients had a narrowed epiconus of Frankel grades A-C than a narrowed cauda equina. At the final follow-up, there were no significant differences in neurological recovery among those with epiconus, conus medullaris, or cauda equina syndrome. Anatomically classifying the narrowest lesion is useful for clarifying the differences and similarities among these three syndromes.
en-copyright=
kn-copyright=

en-aut-name=HatakeyamaYuji
en-aut-sei=Hatakeyama
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HongoMichio
en-aut-sei=Hongo
en-aut-mei=Michio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KidoTadato
en-aut-sei=Kido
en-aut-mei=Tadato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UrayamaMasakazu
en-aut-sei=Urayama
en-aut-mei=Masakazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KasukawaYuji
en-aut-sei=Kasukawa
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SasakiHiroshi
en-aut-sei=Sasaki
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=AizawaToshiaki
en-aut-sei=Aizawa
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KudoDaisuke
en-aut-sei=Kudo
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KimuraRyota
en-aut-sei=Kimura
en-aut-mei=Ryota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OnoYuichi
en-aut-sei=Ono
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KasamaFumihito
en-aut-sei=Kasama
en-aut-mei=Fumihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=MiyakoshiNaohisa
en-aut-sei=Miyakoshi
en-aut-mei=Naohisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Akita Red Cross Hospital
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Akita University Graduate School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Akita Rosai Hospital
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Ogachi Central Hospital
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Akita University Graduate School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Noshiro Kousei Medical Center
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Kitaakita Municipal Hospital
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Akita University Graduate School of Medicine
kn-affil=

affil-num=9
en-affil=Department of Orthopaedic Surgery, Akita University Graduate School of Medicine
kn-affil=

affil-num=10
en-affil=Department of Orthopaedic Surgery, Akita Red Cross Hospital
kn-affil=

affil-num=11
en-affil=Department of Orthopaedic Surgery, Akita University Graduate School of Medicine
kn-affil=

affil-num=12
en-affil=Department of Orthopaedic Surgery, Akita University Graduate School of Medicine
kn-affil=
en-keyword=thoracolumbar spinal injury
kn-keyword=thoracolumbar spinal injury
en-keyword=terminal end of spinal cord
kn-keyword=terminal end of spinal cord
en-keyword=conus medullaris
kn-keyword=conus medullaris
en-keyword=epiconus syndrome
kn-keyword=epiconus syndrome
en-keyword=cauda equina syndrome
kn-keyword=cauda equina syndrome
END

start-ver=1.4
cd-journal=joma
no-vol=30
cd-vols=
no-issue=5
article-no=
start-page=dsad015
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230616
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Genetic basis of lineage-specific evolution of fruit traits in hexaploid persimmon
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Frequent polyploidization events in plants have led to the establishment of many lineage-specific traits representing each species. Little is known about the genetic bases for these specific traits in polyploids, presumably due to plant genomic complexity and their difficulties in applying genetic approaches. Hexaploid Oriental persimmon (Diospyros kaki) has evolved specific fruit characteristics, including wide variations in fruit shapes and astringency. In this study, using whole-genome diploidized/quantitative genotypes from ddRAD-Seq data of 173 persimmon cultivars, we examined their population structures and potential correlations between their structural transitions and variations in nine fruit traits. The population structures of persimmon cultivars were highly randomized and not substantially correlated with the representative fruit traits focused on in this study, except for fruit astringency. With genome-wide association analytic tools considering polyploid alleles, we identified the loci associated with the nine fruit traits; we mainly focused on fruit-shape variations, which have been numerically characterized by principal component analysis of elliptic Fourier descriptors. The genomic regions that putatively underwent selective sweep exhibited no overlap with the loci associated with these persimmon-specific fruit traits. These insights will contribute to understanding the genetic mechanisms by which fruit traits are independently established, possibly due to polyploidization events.
en-copyright=
kn-copyright=

en-aut-name=HoriuchiAyano
en-aut-sei=Horiuchi
en-aut-mei=Ayano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MasudaKanae
en-aut-sei=Masuda
en-aut-mei=Kanae
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShirasawaKenta
en-aut-sei=Shirasawa
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OnoueNoriyuki
en-aut-sei=Onoue
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MatsuzakiRyusuke
en-aut-sei=Matsuzaki
en-aut-mei=Ryusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TaoRyutaro
en-aut-sei=Tao
en-aut-mei=Ryutaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KuboYasutaka
en-aut-sei=Kubo
en-aut-mei=Yasutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=UshijimaKoichiro
en-aut-sei=Ushijima
en-aut-mei=Koichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=AkagiTakashi
en-aut-sei=Akagi
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Kazusa DNA Research Institute
kn-affil=

affil-num=4
en-affil=Institute of Fruit Tree and Tea Science, NARO
kn-affil=

affil-num=5
en-affil=Institute of Fruit Tree and Tea Science, NARO
kn-affil=

affil-num=6
en-affil=Graduate School of Agriculture, Kyoto University
kn-affil=

affil-num=7
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=8
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=9
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=fruit shape
kn-keyword=fruit shape
en-keyword=astringency
kn-keyword=astringency
en-keyword=polyploid
kn-keyword=polyploid
en-keyword=population structure
kn-keyword=population structure
en-keyword=GWAS
kn-keyword=GWAS
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=4
article-no=
start-page=423
end-page=427
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Acute Coronary Spasm Following Pelvic Fracture, Bleeding, and Shock in a Trauma Patient
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We report a case of a patient with severe pelvic fracture who showed concurrent ST elevation on electrocardiogram. A 70-year-old man incurred an unstable pelvic fracture from a motorcycle accident. On admission, he was hemodynamically unstable, and massive transfusion and noradrenaline were administered immediately. Although ST elevation was present in leads II, III, aVF, V5, and V6, cardiac function was preserved; thus, trans-arterial embolization and external fixation for pelvic fracture were given priority. Four days after the injury, he suffered a cardiac arrest, and coronary angiography revealed that the cause of ST elevation and cardiac arrest was coronary vasospasm. Physicians should be aware that pain-related stress and platelet activation as well as use of noradrenaline in severe trauma cases can induce coronary vasospasm.
en-copyright=
kn-copyright=

en-aut-name=YamakawaYasuaki
en-aut-sei=Yamakawa
en-aut-mei=Yasuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MiyashitaKohei
en-aut-sei=Miyashita
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MorizaneAtsushi
en-aut-sei=Morizane
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakeuchiMasato
en-aut-sei=Takeuchi
en-aut-mei=Masato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KawashimaYuta
en-aut-sei=Kawashima
en-aut-mei=Yuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SugimuraTomoko
en-aut-sei=Sugimura
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SaisakaYuichi
en-aut-sei=Saisaka
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Emergency and Critical Care Center, Kochi Health Sciences Center
kn-affil=

affil-num=2
en-affil=Emergency and Critical Care Center, Kochi Health Sciences Center
kn-affil=

affil-num=3
en-affil=Emergency and Critical Care Center, Kochi Health Sciences Center
kn-affil=

affil-num=4
en-affil=Department of Cardiology, Kochi Health Sciences Center
kn-affil=

affil-num=5
en-affil=Department of Radiology, Kochi Health Sciences Center
kn-affil=

affil-num=6
en-affil=Emergency and Critical Care Center, Kochi Health Sciences Center
kn-affil=

affil-num=7
en-affil=Emergency and Critical Care Center, Kochi Health Sciences Center
kn-affil=
en-keyword=coronary spasm angina
kn-keyword=coronary spasm angina
en-keyword=noradrenaline
kn-keyword=noradrenaline
en-keyword=severe trauma
kn-keyword=severe trauma
en-keyword=ST elevation
kn-keyword=ST elevation
en-keyword=treatment strategy
kn-keyword=treatment strategy
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=4
article-no=
start-page=395
end-page=405
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Association of Tumor Necrosis Factor-Alpha with Psychopathology in Patients with Schizophrenia
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We investigated the relationship between serum tumor necrosis factor-alpha (TNF-α) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-α levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-α levels were detected between the patients and controls (p=0.736). TNF-α levels were not correlated with total, positive, negative, general, or composite PANSS scores (all p>0.05). A significant negative correlation was observed between TNF-α levels and the PANSS cognitive factor (ρ=?0.222, p=0.035). A hierarchical regression analysis identified the cognitive factor as a significant predictor of the TNF-α level (beta=?0.258, t=?2.257, p=0.027). There were no significant differences in TNF-α levels among patients treated with different types of antipsychotics (p=0.596). TNF-α levels correlated positively with the age of onset (ρ=0.233, p=0.027) and negatively with illness duration (ρ=?0.247, p=0.019) and antipsychotic treatment duration (ρ=?0.256, p=0.015). These results indicate that TNF-α may be involved in cognitive impairment in schizophrenia, and would be a potential clinical-state marker in schizophrenia.
en-copyright=
kn-copyright=

en-aut-name=PavlovicMarko
en-aut-sei=Pavlovic
en-aut-mei=Marko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=BabicDragan
en-aut-sei=Babic
en-aut-mei=Dragan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=RastovicPejana
en-aut-sei=Rastovic
en-aut-mei=Pejana
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ArapovicJurica
en-aut-sei=Arapovic
en-aut-mei=Jurica
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MartinacMarko
en-aut-sei=Martinac
en-aut-mei=Marko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=JakovacSanja
en-aut-sei=Jakovac
en-aut-mei=Sanja
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=BarbaricRomana
en-aut-sei=Barbaric
en-aut-mei=Romana
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=University Hospital Center Mostar, University of Mostar
kn-affil=

affil-num=2
en-affil=University Hospital Center Mostar, University of Mostar
kn-affil=

affil-num=3
en-affil=University Hospital Center Mostar, University of Mostar
kn-affil=

affil-num=4
en-affil=University Hospital Center Mostar, University of Mostar
kn-affil=

affil-num=5
en-affil=Health Care Center Mostar, University of Mostar
kn-affil=

affil-num=6
en-affil=University Hospital Center Mostar, University of Mostar
kn-affil=

affil-num=7
en-affil=University Hospital Center Mostar, University of Mostar
kn-affil=
en-keyword=tumor necrosis factor-alpha
kn-keyword=tumor necrosis factor-alpha
en-keyword=schizophrenia
kn-keyword=schizophrenia
en-keyword=psychopathology
kn-keyword=psychopathology
en-keyword=immune system
kn-keyword=immune system
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=4
article-no=
start-page=365
end-page=370
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=GATA4 rs61277615, rs73203482, and rs35813172 in Newborns with Transposition of the Great Arteries
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Congenital heart disease is the most common malformative pathology in newborns, with a worldwide incidence at 0.4-5%. We investigated the possible relationship between variations in nucleotide sequences and specific cardiac malformations in the GATA-binding factor 4 (GATA4) exon 1 region by using Sanger sequencing. Forty-four newborns from a third-level neonatal intensive care unit who were diagnosed with nonsyndromic, ductal-dependent congenital heart disease (i.e., transposition of the great arteries or ductal-dependent coarctation of the aorta) were enrolled. Their DNA was extracted using commercial methods and tested using the multiplex ligation-dependent probe amplification (MLPA) technique. The Sanger sequencing for GATA4 exon 1 in the newborns’ DNA identified rs61277615, rs73203482, and rs35813172 variants not reported in the ClinVar archive of human variations in newborns previously diagnosed with transposition of the great arteries (n=5) and coarctation of the aorta (n=1). The identification of these novel variants in newborns with transposition of the great arteries or ductal-dependent coarctation of the aorta may be the first step in determining the variants’ contribution to the occurrence of congenital heart disease. However, these results may be inconclusive, since the observed variants within GATA4 gene were not previously reported.
en-copyright=
kn-copyright=

en-aut-name=MoldovanElena
en-aut-sei=Moldovan
en-aut-mei=Elena
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=B?nescuClaudia
en-aut-sei=B?nescu
en-aut-mei=Claudia
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=CucereaManuela
en-aut-sei=Cucerea
en-aut-mei=Manuela
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MoldovanValeriu
en-aut-sei=Moldovan
en-aut-mei=Valeriu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=GozarLiliana
en-aut-sei=Gozar
en-aut-mei=Liliana
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=Pu?ca?iuLucian
en-aut-sei=Pu?ca?iu
en-aut-mei=Lucian
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Pediatric Intensive Care Unit, Cardiovascular and Transplant Emergency Institute of T?rgu Mure?
kn-affil=

affil-num=2
en-affil=George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T?rgu Mure?
kn-affil=

affil-num=3
en-affil=George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T?rgu Mure?
kn-affil=

affil-num=4
en-affil=T?rgu Mure? County Emergency Clinical Hospital
kn-affil=

affil-num=5
en-affil=George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T?rgu Mure?
kn-affil=

affil-num=6
en-affil=George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T?rgu Mure?
kn-affil=
en-keyword=transposition of the great arteries
kn-keyword=transposition of the great arteries
en-keyword=ductal-dependent coarctation of the aorta
kn-keyword=ductal-dependent coarctation of the aorta
en-keyword=GATA4
kn-keyword=GATA4
en-keyword=MLPA
kn-keyword=MLPA
en-keyword=Sanger sequencing
kn-keyword=Sanger sequencing
END

start-ver=1.4
cd-journal=joma
no-vol=63
cd-vols=
no-issue=12
article-no=
start-page=1826
end-page=1839
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220518
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Plant Hormonomics: A Key Tool for Deep Physiological Phenotyping to Improve Crop Productivity
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Agriculture is particularly vulnerable to climate change. To cope with the risks posed by climate-related stressors to agricultural production, global population growth, and changes in food preferences, it is imperative to develop new climate-smart crop varieties with increased yield and environmental resilience. Molecular genetics and genomic analyses have revealed that allelic variations in genes involved in phytohormone-mediated growth regulation have greatly improved productivity in major crops. Plant science has remarkably advanced our understanding of the molecular basis of various phytohormone-mediated events in plant life. These findings provide essential information for improving the productivity of crops growing in changing climates. In this review, we highlight the recent advances in plant hormonomics (multiple phytohormone profiling) and discuss its application to crop improvement. We present plant hormonomics as a key tool for deep physiological phenotyping, focusing on representative plant growth regulators associated with the improvement of crop productivity. Specifically, we review advanced methodologies in plant hormonomics, highlighting mass spectrometry- and nanosensor-based plant hormone profiling techniques. We also discuss the applications of plant hormonomics in crop improvement through breeding and agricultural management practices.
en-copyright=
kn-copyright=

en-aut-name=HirayamaTakashi
en-aut-sei=Hirayama
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MochidaKeiichi
en-aut-sei=Mochida
en-aut-mei=Keiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil=RIKEN Center for Sustainable Resource Science
kn-affil=
en-keyword=Biosensor
kn-keyword=Biosensor
en-keyword=Biostimulant
kn-keyword=Biostimulant
en-keyword=Breeding
kn-keyword=Breeding
en-keyword=Mass spectrometry
kn-keyword=Mass spectrometry
en-keyword=Phytohormone
kn-keyword=Phytohormone
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=3
article-no=
start-page=269
end-page=277
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=2023
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Elucidation of genetic variation and population structure of melon genetic resources in the NARO Genebank, and construction of the World Melon Core Collection
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Numerous genetic resources of major crops have been introduced from around the world and deposited in Japanese National Agriculture and Food Research Organization (NARO) Genebank. Understanding their genetic variation and selecting a representative subset (“core collection”) are essential for optimal management and efficient use of genetic resources. In this study, we conducted genotyping-by-sequencing (GBS) to characterize the genetic relationships and population structure in 755 accessions of melon genetic resources. The GBS identified 39,324 single-nucleotide polymorphisms (SNPs) that are distributed throughout the melon genome with high density (one SNP/10.6 kb). The phylogenetic relationships and population structure inferred using this SNP dataset are highly associated with the cytoplasm type and geographical origin. Our results strongly support the recent hypothesis that cultivated melon was established in Africa and India through multiple independent domestication events. Finally, we constructed a World Melon Core Collection that covers at least 82% of the genetic diversity and has a wide range of geographical origins and fruit morphology. The genome-wide SNP dataset, phylogenetic relationships, population structure, and the core collection provided in this study should largely contribute to genetic research, breeding, and genetic resource preservation in melon.
en-copyright=
kn-copyright=

en-aut-name=ShigitaGentaro
en-aut-sei=Shigita
en-aut-mei=Gentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=DungTran Phuong
en-aut-sei=Dung
en-aut-mei=Tran Phuong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=PervinMst. Naznin
en-aut-sei=Pervin
en-aut-mei=Mst. Naznin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=DuongThanh-Thuy
en-aut-sei=Duong
en-aut-mei=Thanh-Thuy
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ImohOdirich Nnennaya
en-aut-sei=Imoh
en-aut-mei=Odirich Nnennaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MondenYuki
en-aut-sei=Monden
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NishidaHidetaka
en-aut-sei=Nishida
en-aut-mei=Hidetaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TanakaKatsunori
en-aut-sei=Tanaka
en-aut-mei=Katsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SugiyamaMitsuhiro
en-aut-sei=Sugiyama
en-aut-mei=Mitsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KawazuYoichi
en-aut-sei=Kawazu
en-aut-mei=Yoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=TomookaNorihiko
en-aut-sei=Tomooka
en-aut-mei=Norihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KatoKenji
en-aut-sei=Kato
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=7
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=8
en-affil=Faculty of Agriculture and Life Science, Hirosaki University
kn-affil=

affil-num=9
en-affil=Institute of Vegetable and Floriculture Science, National Agriculture and Food Research Organization (NARO)
kn-affil=

affil-num=10
en-affil=Institute of Vegetable and Floriculture Science, National Agriculture and Food Research Organization (NARO)
kn-affil=

affil-num=11
en-affil=Research Center of Genetic Resources, National Agriculture and Food Research Organization (NARO)
kn-affil=

affil-num=12
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=Cucumis melo
kn-keyword=Cucumis melo
en-keyword=Cucurbitaceae
kn-keyword=Cucurbitaceae
en-keyword=genotyping-by-sequencing
kn-keyword=genotyping-by-sequencing
en-keyword=genetic resource
kn-keyword=genetic resource
en-keyword=genetic diversity
kn-keyword=genetic diversity
en-keyword=crop origin
kn-keyword=crop origin
en-keyword=core collection
kn-keyword=core collection
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=918273
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220718
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Sea Surface Temperature and Salinity in Lombok Strait Reconstructed From Coral Sr/Ca and δ18O, 1962?2012
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Coral geochemical tracers have been used in studies of the paleoclimatology and paleoceanography of the tropics and subtropics. We measured Sr/Ca and oxygen isotope ratios (δ18O) in a coral sample collected from the southern part of Lombok Strait, a significant outlet of the Indonesian Throughflow (ITF) to the Indian Ocean, to reconstruct the historical record of sea surface temperature (SST) and seawater δ18O. Seawater δ18O can be used to approximate sea surface salinity (SSS) because it reflects the balance of evaporation and precipitation. The resulting time series reconstructed SST and SSS, covering the period 1962?2012, shows no clear trend of global warming, although the record includes a large cooling event (~4°C) during 1996?1997. Although neither SST nor SSS shows a systematic relationship with El Ni?o?Southern Oscillation and Indian Ocean Dipole (IOD), weak but significant correlations are found partly. In addition, the coral data show signals of major IOD and El Ni?o events in 1994 and 1997, respectively, although climatic trends recorded in the coral are not consistent with those found along the Java-Sumatra coast. To evaluate other influences on the ITF in Lombok Strait, we compared our coral record with coral records from sites in the Java Sea, the southern part of Makassar Strait, and Ombai Strait. During the northwest monsoon (December?January?February), variations in SST and SSS at Lombok Strait site are similar to those at the Java Sea and southern Makassar sites for the period 1962?1995, which suggests that low-salinity water from the Java Sea is carried at least to the southern part of Makassar Strait where it suppresses the ITF upstream from Lombok Strait. However, the SST and SSS records differ at the three sites during the southeast monsoon (June?July?August), indicating that surface conditions in Lombok Strait vary separately from those in the Java Sea. In the longer term, although global warming has been widely identified in the Indonesian Seas, the coral record shows no clear warming trend in the southern part of Lombok Strait, where fluctuations in the ITF may be modulating the distribution of heat in the surface waters of the western Pacific and eastern Indian Ocean.
en-copyright=
kn-copyright=

en-aut-name=GendaAi
en-aut-sei=Genda
en-aut-mei=Ai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IkeharaMinoru
en-aut-sei=Ikehara
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SuzukiAtsushi
en-aut-sei=Suzuki
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ArmanAli
en-aut-sei=Arman
en-aut-mei=Ali
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=InoueMayuri
en-aut-sei=Inoue
en-aut-mei=Mayuri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Center for Advanced Marine Core Research, Kochi University
kn-affil=

affil-num=3
en-affil=Geological Survey of Japan, National Institute of Advanced Industrial Science and Technology (AIST)
kn-affil=

affil-num=4
en-affil=Research and Technology Center for Application of Isotope and Radiation, National Research and Innovation Agency
kn-affil=

affil-num=5
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=coral
kn-keyword=coral
en-keyword=geochemical tracers
kn-keyword=geochemical tracers
en-keyword=Sr/Ca
kn-keyword=Sr/Ca
en-keyword=δ 18O
kn-keyword=δ 18O
en-keyword=sea surface temperature
kn-keyword=sea surface temperature
en-keyword=salinity
kn-keyword=salinity
en-keyword=Lombok Strait
kn-keyword=Lombok Strait
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=1
article-no=
start-page=8954
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230602
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Refining the evolutionary tree of the horse Y chromosome
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The Y chromosome carries information about the demography of paternal lineages, and thus, can prove invaluable for retracing both the evolutionary trajectory of wild animals and the breeding history of domesticates. In horses, the Y chromosome shows a limited, but highly informative, sequence diversity, supporting the increasing breeding influence of Oriental lineages during the last 1500 years. Here, we augment the primary horse Y-phylogeny, which is currently mainly based on modern horse breeds of economic interest, with haplotypes (HT) segregating in remote horse populations around the world. We analyze target enriched sequencing data of 5 Mb of the Y chromosome from 76 domestic males, together with 89 whole genome sequenced domestic males and five Przewalski's horses from previous studies. The resulting phylogeny comprises 153 HTs defined by 2966 variants and offers unprecedented resolution into the history of horse paternal lineages. It reveals the presence of a remarkable number of previously unknown haplogroups in Mongolian horses and insular populations. Phylogenetic placement of HTs retrieved from 163 archaeological specimens further indicates that most of the present-day Y-chromosomal variation evolved after the domestication process that started around 4200 years ago in the Western Eurasian steppes. Our comprehensive phylogeny significantly reduces ascertainment bias and constitutes a robust evolutionary framework for analyzing horse population dynamics and diversity.
en-copyright=
kn-copyright=

en-aut-name=BozlakElif
en-aut-sei=Bozlak
en-aut-mei=Elif
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=RadovicLara
en-aut-sei=Radovic
en-aut-mei=Lara
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=RemerViktoria
en-aut-sei=Remer
en-aut-mei=Viktoria
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=RiglerDoris
en-aut-sei=Rigler
en-aut-mei=Doris
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AllenLucy
en-aut-sei=Allen
en-aut-mei=Lucy
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=BremGottfried
en-aut-sei=Brem
en-aut-mei=Gottfried
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=StalderGabrielle
en-aut-sei=Stalder
en-aut-mei=Gabrielle
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=CastanedaCaitlin
en-aut-sei=Castaneda
en-aut-mei=Caitlin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=CothranGus
en-aut-sei=Cothran
en-aut-mei=Gus
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=RaudseppTerje
en-aut-sei=Raudsepp
en-aut-mei=Terje
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OkudaYu
en-aut-sei=Okuda
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=MoeKyaw Kyaw
en-aut-sei=Moe
en-aut-mei=Kyaw Kyaw
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=MoeHla Hla
en-aut-sei=Moe
en-aut-mei=Hla Hla
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=KounnavongsaBounthavone
en-aut-sei=Kounnavongsa
en-aut-mei=Bounthavone
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=KeonouchanhSoukanh
en-aut-sei=Keonouchanh
en-aut-mei=Soukanh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=VanNguyen Huu
en-aut-sei=Van
en-aut-mei=Nguyen Huu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=VuVan Hai
en-aut-sei=Vu
en-aut-mei=Van Hai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=ShahManoj Kumar
en-aut-sei=Shah
en-aut-mei=Manoj Kumar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=NishiboriMasahide
en-aut-sei=Nishibori
en-aut-mei=Masahide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=KazymbetPolat
en-aut-sei=Kazymbet
en-aut-mei=Polat
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=BakhtinMeirat
en-aut-sei=Bakhtin
en-aut-mei=Meirat
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=ZhunushovAsankadyr
en-aut-sei=Zhunushov
en-aut-mei=Asankadyr
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=PaulRipon Chandra
en-aut-sei=Paul
en-aut-mei=Ripon Chandra
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

en-aut-name=DashnyamBumbein
en-aut-sei=Dashnyam
en-aut-mei=Bumbein
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=24
ORCID=

en-aut-name=NozawaKen
en-aut-sei=Nozawa
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=25
ORCID=

en-aut-name=AlmarzookSaria
en-aut-sei=Almarzook
en-aut-mei=Saria
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=26
ORCID=

en-aut-name=BrockmannGudrun A.
en-aut-sei=Brockmann
en-aut-mei=Gudrun A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=27
ORCID=

en-aut-name=ReissmannMonika
en-aut-sei=Reissmann
en-aut-mei=Monika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=28
ORCID=

en-aut-name=AntczakDouglas F.
en-aut-sei=Antczak
en-aut-mei=Douglas F.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=29
ORCID=

en-aut-name=MillerDonald C.
en-aut-sei=Miller
en-aut-mei=Donald C.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=30
ORCID=

en-aut-name=SadeghiRaheleh
en-aut-sei=Sadeghi
en-aut-mei=Raheleh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=31
ORCID=

en-aut-name=Butler-WemkenInes von
en-aut-sei=Butler-Wemken
en-aut-mei=Ines von
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=32
ORCID=

en-aut-name=KostarasNikos
en-aut-sei=Kostaras
en-aut-mei=Nikos
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=33
ORCID=

en-aut-name=HanHaige
en-aut-sei=Han
en-aut-mei=Haige
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=34
ORCID=

en-aut-name=ManglaiDugarjaviin
en-aut-sei=Manglai
en-aut-mei=Dugarjaviin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=35
ORCID=

en-aut-name=AbdurasulovAbdugani
en-aut-sei=Abdurasulov
en-aut-mei=Abdugani
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=36
ORCID=

en-aut-name=SukhbaatarBoldbaatar
en-aut-sei=Sukhbaatar
en-aut-mei=Boldbaatar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=37
ORCID=

en-aut-name=Ropka-MolikKatarzyna
en-aut-sei=Ropka-Molik
en-aut-mei=Katarzyna
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=38
ORCID=

en-aut-name=Stefaniuk-SzmukierMonika
en-aut-sei=Stefaniuk-Szmukier
en-aut-mei=Monika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=39
ORCID=

en-aut-name=LopesMaria Susana
en-aut-sei=Lopes
en-aut-mei=Maria Susana
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=40
ORCID=

en-aut-name=MachadoArtur da C?mara
en-aut-sei=Machado
en-aut-mei=Artur da C?mara
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=41
ORCID=

en-aut-name=KalashnikovValery V.
en-aut-sei=Kalashnikov
en-aut-mei=Valery V.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=42
ORCID=

en-aut-name=KalinkovaLiliya
en-aut-sei=Kalinkova
en-aut-mei=Liliya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=43
ORCID=

en-aut-name=ZaitevAlexander M.
en-aut-sei=Zaitev
en-aut-mei=Alexander M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=44
ORCID=

en-aut-name=Novoa-BravoMiguel
en-aut-sei=Novoa-Bravo
en-aut-mei=Miguel
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=45
ORCID=

en-aut-name=LindgrenGabriella
en-aut-sei=Lindgren
en-aut-mei=Gabriella
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=46
ORCID=

en-aut-name=BrooksSamantha
en-aut-sei=Brooks
en-aut-mei=Samantha
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=47
ORCID=

en-aut-name=RosaLaura Patterson
en-aut-sei=Rosa
en-aut-mei=Laura Patterson
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=48
ORCID=

en-aut-name=OrlandoLudovic
en-aut-sei=Orlando
en-aut-mei=Ludovic
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=49
ORCID=

en-aut-name=JurasRytis
en-aut-sei=Juras
en-aut-mei=Rytis
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=50
ORCID=

en-aut-name=KuniedaTetsuo
en-aut-sei=Kunieda
en-aut-mei=Tetsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=51
ORCID=

en-aut-name=WallnerBarbara
en-aut-sei=Wallner
en-aut-mei=Barbara
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=52
ORCID=

affil-num=1
en-affil=Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna
kn-affil=

affil-num=2
en-affil=Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna
kn-affil=

affil-num=3
en-affil=Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna
kn-affil=

affil-num=4
en-affil=Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna
kn-affil=

affil-num=5
en-affil=Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna
kn-affil=

affil-num=6
en-affil=Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna
kn-affil=

affil-num=7
en-affil=Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna
kn-affil=

affil-num=8
en-affil=School of Veterinary Medicine and Biomedical Sciences, Texas A&M University
kn-affil=

affil-num=9
en-affil=School of Veterinary Medicine and Biomedical Sciences, Texas A&M University
kn-affil=

affil-num=10
en-affil=School of Veterinary Medicine and Biomedical Sciences, Texas A&M University
kn-affil=

affil-num=11
en-affil=Museum of Dinosaur Research, Okayama University of Science
kn-affil=

affil-num=12
en-affil=Department of Pathology and Microbiology, University of Veterinary Science
kn-affil=

affil-num=13
en-affil=Department of Genetics and Animal Breeding, University of Veterinary Science
kn-affil=

affil-num=14
en-affil=National Agriculture and Forestry Research Institute (Lao) Resources, Livestock Research Center
kn-affil=

affil-num=15
en-affil=Faculty of Animal Science and Veterinary Medicine, University of Agriculture and Forestry, Hue University
kn-affil=

affil-num=16
en-affil=Faculty of Animal Science and Veterinary Medicine, University of Agriculture and Forestry, Hue University
kn-affil=

affil-num=17
en-affil=Faculty of Animal Science and Veterinary Medicine, University of Agriculture and Forestry, Hue University
kn-affil=

affil-num=18
en-affil=Faculty of Animal Science, Veterinary Science and Fisheries, Agriculture and Forestry University
kn-affil=

affil-num=19
en-affil=Graduate School of Integrated Sciences for Life, Hiroshima University
kn-affil=

affil-num=20
en-affil=Radiobiological Research Institute, JSC Astana Medical University
kn-affil=

affil-num=21
en-affil=Institute of Biotechnology, National Academy of Sciences of the Kyrgyz Republic
kn-affil=

affil-num=22
en-affil=Institute of Biotechnology, National Academy of Sciences of the Kyrgyz Republic
kn-affil=

affil-num=23
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=24
en-affil=Institute of Biological Sciences, Mongolian Academy of Sciences
kn-affil=

affil-num=25
en-affil=Primate Research Institute, Kyoto University
kn-affil=

affil-num=26
en-affil=Albrecht Daniel Thaer?Institut, Humboldt-Universit?t zu Berlin
kn-affil=

affil-num=27
en-affil=Albrecht Daniel Thaer?Institut, Humboldt-Universit?t zu Berlin
kn-affil=

affil-num=28
en-affil=Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University
kn-affil=

affil-num=29
en-affil=Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University
kn-affil=

affil-num=30
en-affil=Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University
kn-affil=

affil-num=31
en-affil=Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University
kn-affil=

affil-num=32
en-affil=Barb Horse Breeding Organisation VFZB E. V., Verein der Freunde und Z?chter Des Berberpferdes E.V.
kn-affil=

affil-num=33
en-affil=Amaltheia
kn-affil=

affil-num=34
en-affil=Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, College of Animal Science, Equine Research Center, Inner Mongolia Agricultural University
kn-affil=

affil-num=35
en-affil=Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, College of Animal Science, Equine Research Center, Inner Mongolia Agricultural University
kn-affil=

affil-num=36
en-affil=Department of Agriculture, Faculty of Natural Sciences and Geography, Osh State University
kn-affil=

affil-num=37
en-affil=Sector of Surveillance and Diagnosis of Infectious Diseases, State Central Veterinary Laboratory
kn-affil=

affil-num=38
en-affil=National Research Institute of Animal Production, Animal Molecular Biology
kn-affil=

affil-num=39
en-affil=National Research Institute of Animal Production, Animal Molecular Biology
kn-affil=

affil-num=40
en-affil=Biotechnology Centre of Azores, University of Azores
kn-affil=

affil-num=41
en-affil=Biotechnology Centre of Azores, University of Azores
kn-affil=

affil-num=42
en-affil=All-Russian Research Institute for Horse Breeding
kn-affil=

affil-num=43
en-affil=All-Russian Research Institute for Horse Breeding
kn-affil=

affil-num=44
en-affil=All-Russian Research Institute for Horse Breeding
kn-affil=

affil-num=45
en-affil=Gen?tica Animal de Colombia SAS.
kn-affil=

affil-num=46
en-affil=Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences
kn-affil=

affil-num=47
en-affil=Department of Animal Science, UF Genetics Institute, University of Florida
kn-affil=

affil-num=48
en-affil=Department of Agriculture and Industry, Sul Ross State University
kn-affil=

affil-num=49
en-affil=Centre d’Anthropobiologie et de G?nomique de Toulouse, Universit? Paul Sabatier
kn-affil=

affil-num=50
en-affil=School of Veterinary Medicine and Biomedical Sciences, Texas A&M University
kn-affil=

affil-num=51
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=52
en-affil=Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=165
cd-vols=
no-issue=2
article-no=
start-page=411
end-page=421
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202302
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Modified single-patch repair for atrioventricular septal defects results in good functional outcomes in the absence of deep ventricular septal defects
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objectives<br>
We compared 2-patch repair (TP) with modified single-patch repair (MSP) for complete atrioventricular septal defects and evaluated their effect on the left atrioventricular valve (LAVV) competence. We also identified risk factors for unfavorable functional outcomes.<br>
<br>
Methods<br>
This retrospective study included 118 patients with complete atrioventricular septal defects who underwent intracardiac repair from 1998 to 2020 (MSP: 69; TP: 49). The median follow-up period was 10.4 years. The functional outcome of freedom from moderate or greater LAVV regurgitation (LAVVR) was estimated using the Kaplan?Meier method.<br>
<br>
Results<br>
The hospital mortality was 1.7% (2/118) and late mortality was 0.8% (1/118). Eight patients required LAVV-related reoperation (MSP: 4; TP: 4) and none required left ventricular outflow tract-related reoperation. In the MSP group without LAVV anomaly, the receiver operating characteristic curve analysis revealed that the ventricular septal defect (VSD) depth was strongly associated with moderate or greater postoperative LAVVR, with the best cutoff at 10.9 mm. When stratified according to the combination of intracardiac repair type and VSD depth, the MSP-deep VSD (VSD depth >11 mm) group showed the worst LAVV competence among the 4 groups (P = .002). According to multivariate analysis, weight <4.0 kg, LAVV anomaly, and moderate or greater preoperative LAVVR were independent risk factors for moderate or greater postoperative LAVVR, whereas MSP was not a risk factor.<br>
<br>
Conclusions<br>
Postoperative LAVVR remains an obstacle to improved functional outcomes. MSP provides LAVV competence similar to TP unless deep VSD is present. The surgical approach should be selected on the basis of anatomical variations, specifically VSD depth.
en-copyright=
kn-copyright=

en-aut-name=KobayashiYasuyuki
en-aut-sei=Kobayashi
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KasaharaShingo
en-aut-sei=Kasahara
en-aut-mei=Shingo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SanoShunji
en-aut-sei=Sano
en-aut-mei=Shunji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KotaniYasuhiro
en-aut-sei=Kotani
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences and Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences and Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Pediatric Cardiothoracic Surgery, University of California
kn-affil=

affil-num=4
en-affil=Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences and Okayama University Hospital
kn-affil=
en-keyword=atrioventricular septal defect
kn-keyword=atrioventricular septal defect
en-keyword=modified single-patch repair
kn-keyword=modified single-patch repair
en-keyword=left atrioventricular valve regurgitation
kn-keyword=left atrioventricular valve regurgitation
en-keyword=ventricular septal defect
kn-keyword=ventricular septal defect
END

start-ver=1.4
cd-journal=joma
no-vol=29
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=27
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Geology of the Paleogene to Neogene successions and gentle upwarping of the Kibi Plateau Surface, surrounding area of Kibichuou Town, Okayama Prefecture, Southwest Japan
kn-title=岡山県吉備中央町賀陽周辺の古第三系〜新第三系の地質と吉備高原面のゆるやかな曲隆
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The Paleogene to Neogene successions which are composed of the Paleogene Kayo Formation, the late Oligocene to earliest Miocene Yagane Formation and the middle Miocene Ukan Formation are sporadically distributed in the Kibi Plateau region, surrounding area of Kibichuou Town, Okayama Prefecture, Southwest Japan. The gravel of the Kayo Formation occupied paleo-valley of Pre-Paleogene basement. The Yagane and Ukan formations unconformably overlay Pre-Paleogene rocks and occupy the gentle valley on the Kibi Surface as valley fill deposits.<br>
The fluvial of the Kayo Formation is mainly composed of conglomerate with minor amount of sandstone and mudstone. The fluvial Yagane Formation is mainly composed of conglomerate and associated with sandstone, mudstone and coal beds. The marine Ukan Formation is subdivided into 3 members, the Yamagata Muddy sandstone Member (YMM), the Shimoyokomi Sandstone Member (SSM) and the Tsuneyama Mudstone Member (TMM) in ascending order. The YMM is characterized by the bio-disturbed very poorly sorted muddy sandstone with frequent burrows, which indicate tidal flat deposits. The SSM is mainly composed of parallel bedded well-sorted sandstone with occasional burrows, which suggest near shore deposits. The TMM is composed of homogeneous clay rich mudstone, which implies off shore deposits.<br>
The boundary between the SSM and TMM (the contact of the sandstone and mudstone) is distinctive and correlative throughout the study area. The boundary is considered to be formed under similar water depth. The variations of the boundary height indicate a later ground movement. From the north to the south in about 25km distance, the height of the boundary changes 260m (in Ukan), 300m (in Takeshou), 360m (in Kibikogentoshi) and 260m (in Nichiouji). It indicates that a very gentle upwarping of the Kibi Plateau Surface was formed after the deposition of the Miocene.
en-copyright=
kn-copyright=

en-aut-name=TANAKAHajime
en-aut-sei=TANAKA
en-aut-mei=Hajime
kn-aut-name=田中元
kn-aut-sei=田中
kn-aut-mei=元
aut-affil-num=1
ORCID=

en-aut-name=SUZUKIShigeyuki
en-aut-sei=SUZUKI
en-aut-mei=Shigeyuki
kn-aut-name=鈴木茂之
kn-aut-sei=鈴木
kn-aut-mei=茂之
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Seibu Engineering Consultants Co., Ltd.
kn-affil=西部技術コンサルタント株式会社

affil-num=2
en-affil=Department of Earth Sciences, Okayama University
kn-affil=岡山大学理学部地球科学科
en-keyword=Kibi Plateau Surface
kn-keyword=Kibi Plateau Surface
en-keyword=Upwarping
kn-keyword=Upwarping
en-keyword=Miocene
kn-keyword=Miocene
en-keyword=Ukan Formation
kn-keyword=Ukan Formation
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=家族性大腸腺腫症における胃腫瘍の内視鏡所見は表現型差異と異型度に関連する
kn-title=Endoscopic findings of gastric neoplasms in familial adenomatous polyposis are associated with the phenotypic variations and grades of dysplasia
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KOBASHIMayu
en-aut-sei=KOBASHI
en-aut-mei=Mayu
kn-aut-name=小橋真由
kn-aut-sei=小橋
kn-aut-mei=真由
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=2
article-no=
start-page=219
end-page=229
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=2023
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Melon diversity on the Silk Road by molecular phylogenetic analysis in Kazakhstan melons
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To uncover population structure, phylogenetic relationship, and diversity in melons along the famous Silk Road, a seed size measurement and a phylogenetic analysis using five chloroplast genome markers, 17 RAPD markers and 11 SSR markers were conducted for 87 Kazakh melon accessions with reference accessions. Kazakh melon accessions had large seed with exception of two accessions of weedy melon, Group Agrestis, and consisted of three cytoplasm types, of which Ib-1/-2 and Ib-3 were dominant in Kazakhstan and nearby areas such as northwestern China, Central Asia and Russia. Molecular phylogeny showed that two unique genetic groups, STIa-2 with Ib-1/-2 cytoplasm and STIa-1 with Ib-3 cytoplasm, and one admixed group, STIAD combined with STIa and STIb, were prevalent across all Kazakh melon groups. STIAD melons that phylogenetically overlapped with STIa-1 and STIa-2 melons were frequent in the eastern Silk Road region, including Kazakhstan. Evidently, a small population contributed to melon development and variation in the eastern Silk Road. Conscious preservation of fruit traits specific to Kazakh melon groups is thought to play a role in the conservation of Kazakh melon genetic variation during melon production, where hybrid progenies were generated through open pollination.
en-copyright=
kn-copyright=

en-aut-name=TanakaKatsunori
en-aut-sei=Tanaka
en-aut-mei=Katsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SugiyamaMitsuhiro
en-aut-sei=Sugiyama
en-aut-mei=Mitsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShigitaGentaro
en-aut-sei=Shigita
en-aut-mei=Gentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MurakamiRyoma
en-aut-sei=Murakami
en-aut-mei=Ryoma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=DuongThanh-Thuy
en-aut-sei=Duong
en-aut-mei=Thanh-Thuy
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=AierkenYasheng
en-aut-sei=Aierken
en-aut-mei=Yasheng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ArtemyevaAnna M
en-aut-sei=Artemyeva
en-aut-mei=Anna M
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MamypbelovZharas
en-aut-sei=Mamypbelov
en-aut-mei=Zharas
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=IshikawaRyuji
en-aut-sei=Ishikawa
en-aut-mei=Ryuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=NishidaHidetaka
en-aut-sei=Nishida
en-aut-mei=Hidetaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KatoKenji
en-aut-sei=Kato
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Faculty of Agriculture and Life Science, Hirosaki University
kn-affil=

affil-num=2
en-affil=Institute of Vegetable and Floriculture Science, National Agriculture and Food Research Organization (NARO)
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Faculty of Agriculture and Life Science, Hirosaki University
kn-affil=

affil-num=5
en-affil=Faculty of Agronomy, University of Agriculture and Forestry, Hue University
kn-affil=

affil-num=6
en-affil=Center for Hami Melon, Xinjiang Academy of Agricultural Sciences
kn-affil=

affil-num=7
en-affil=All-Russian Institute of Plant Genetic Resources on the name of N.I.Vavilov (VIR)
kn-affil=

affil-num=8
en-affil=Kazakhstan Research Institute of Potato and Vegetable Growing LLC
kn-affil=

affil-num=9
en-affil=Faculty of Agriculture and Life Science, Hirosaki University
kn-affil=

affil-num=10
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=11
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=Central Asia
kn-keyword=Central Asia
en-keyword=Cucumis melo
kn-keyword=Cucumis melo
en-keyword=diversity
kn-keyword=diversity
en-keyword=genetic resources
kn-keyword=genetic resources
en-keyword=on-farm conservation
kn-keyword=on-farm conservation
END

start-ver=1.4
cd-journal=joma
no-vol=48
cd-vols=
no-issue=3
article-no=
start-page=533
end-page=540
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202203
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Impact of the national sarcoma guidelines on the prevalence and outcome of inadvertent excisions of soft tissue sarcomas: An observational study from a UK tertiary referral centre
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objectives: This study aims to investigate the impact of the national guideline on the prevalence and outcome in patients with soft-tissue sarcoma (STS) who had undergone inadvertent excisions.<br>
Methods: A total of 2336 patients were referred to a tertiary sarcoma centre from six regions (North East, North West, East Midlands, West Midlands, Wales, and South West) in the United Kingdom with a diagnosis of STS between 1996 and 2016, of whom 561 patients (24.0%) had undergone inadvertent excisions. Patients were categorised into two groups of 10-year periods pre and post the National Institute for Health and Clinical Excellence (NICE) guideline implementation in 2006.<br>
Results: The proportion of inadvertent excisions decreased after the NICE guideline implementation: 27.2% (pre-NICE) versus 19.8% (post-NICE) (p = 0.001). A substantial regional variation (17.4%?34.5%) in the proportion of inadvertent excisions in the pre-NICE era was reduced in the post-NICE era (14.3%?22.4%). The 5-year disease-specific survival was 77.7% (pre-NICE) versus 75.6% (post-NICE) (p = 0.961) and there was a trend toward lower incidence of local recurrence in the post-NICE era; 13.5% (pre-NICE) versus 10.5% (post-NICE) (p = 0.522). Multivariate analyses revealed that residual tumours in re-resection specimens were independently associated with an increased risk of disease-specific mortality (HR, 3.35; p < 0.001) and local recurrence (HR, 1.99; p = 0.017), which was significantly reduced after the NICE guideline implementation (53.2% versus 42.0%; p = 0.022).<br>
Conclusions: The NICE guideline implementation reduced the proportion of patients with STS who had undergone inadvertent excisions and residual tumour in re-resection specimens, indicating an improved pre-referral management of STSs.
en-copyright=
kn-copyright=

en-aut-name=FujiwaraTomohiro
en-aut-sei=Fujiwara
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=EvansScott
en-aut-sei=Evans
en-aut-mei=Scott
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=StevensonJonathan
en-aut-sei=Stevenson
en-aut-mei=Jonathan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TsudaYusuke
en-aut-sei=Tsuda
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=GregoryJonathan
en-aut-sei=Gregory
en-aut-mei=Jonathan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=GrimerRobert
en-aut-sei=Grimer
en-aut-mei=Robert
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=AbuduAdesegun
en-aut-sei=Abudu
en-aut-mei=Adesegun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Oncology Service, The Royal Orthopaedic Hospital NHS Foundation Trust
kn-affil=

affil-num=3
en-affil=Oncology Service, The Royal Orthopaedic Hospital NHS Foundation Trust
kn-affil=

affil-num=4
en-affil=Oncology Service, The Royal Orthopaedic Hospital NHS Foundation Trust
kn-affil=

affil-num=5
en-affil=Oncology Service, The Royal Orthopaedic Hospital NHS Foundation Trust
kn-affil=

affil-num=6
en-affil=Oncology Service, The Royal Orthopaedic Hospital NHS Foundation Trust
kn-affil=

affil-num=7
en-affil=Oncology Service, The Royal Orthopaedic Hospital NHS Foundation Trust
kn-affil=
en-keyword=NICE guideline
kn-keyword=NICE guideline
en-keyword=Soft-tissue sarcoma
kn-keyword=Soft-tissue sarcoma
en-keyword=Inadvertent excision
kn-keyword=Inadvertent excision
en-keyword=Prevalence
kn-keyword=Prevalence
en-keyword=Outcome
kn-keyword=Outcome
END

start-ver=1.4
cd-journal=joma
no-vol=128
cd-vols=
no-issue=5
article-no=
start-page=e2022JB025670
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230425
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Lithium Isotope Constraints on Slab and Mantle Contribution to Arc Magmas
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Dehydration of subducting oceanic lithosphere (slab) induces Li-isotope fractionation between the fluid and the slab, suggested by the δ7Li variation (?10‰) in exhumed subduction complexes. Given that arc magmas represent melt of the supraslab mantle, a large δ7Li variation is anticipated for arc volcanic rocks. However, the δ7Li values in these rocks are mostly homogeneous within the range of mid-ocean ridge basalts (+1.6 to +5.6‰). The lack of a subduction-related δ7Li signature has been explained by (1) homogenization by mixing of different magma sources, (2) loss of Li from the slab via dehydration, or (3) homogenization by diffusive exchange of slab-derived Li and the mantle. The Chugoku district in SW Japan is an ideal place to study the process responsible for Li-isotope variation in arc magmas, since the Chugoku volcanic rocks show large δ7Li variation (?1.9 to +7.4‰). High δ7Li values (+6.3 to +7.4‰) are found in some high-Sr andesites and dacites (adakites) whereas low δ7Li values (?1.0 to ?0.1‰) are found in high-Mg andesites. The parental magmas of these rocks have been sourced from subducted oceanic crust and sediments, respectively, with various extents of the interaction with wedge mantle. The limited extents of Li isotope modification are indicated by the similarity of the δ7Li values of these rocks and their supposed sources. The models for a slab dehydration and a diffusive exchange between slab-derived melt and mantle demonstrate that the δ7Li signatures of the sources can be preserved in the adakites if they ascent rapidly in mantle.
en-copyright=
kn-copyright=

en-aut-name=ZhangWei
en-aut-sei=Zhang
en-aut-mei=Wei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KitagawaHiroshi
en-aut-sei=Kitagawa
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakamuraEizo
en-aut-sei=Nakamura
en-aut-mei=Eizo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=2
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=3
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=
en-keyword=SW Japan
kn-keyword=SW Japan
en-keyword=slab
kn-keyword=slab
en-keyword=lithium isotope
kn-keyword=lithium isotope
en-keyword=arc magma
kn-keyword=arc magma
en-keyword=melt transport
kn-keyword=melt transport
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=4
article-no=
start-page=417
end-page=422
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202304
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Relationships between squamous cell carcinoma antigen and cytokeratin 19 fragment values and renal function in oral cancer patients
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Squamous cell carcinoma antigen (SCC-Ag) and cytokeratin 19 fragment (CYFRA) are used to screen and monitor oral cancer patients. However, recent studies have reported that tumour markers become elevated as renal function decreases, regardless of tumour progression. A retrospective study was performed of 423 oral cancer patients who underwent blood testing for these tumour markers and other blood analytes during a 10-year period. The values of SCC-Ag and CYFRA increased significantly with decreasing renal function (P < 0.01), and the values were abnormal at a median 2.6 ng/ml for SCC-Ag and 4.7 ng/ml for CYFRA in the group with estimated glomerular filtration rate (eGFR) values of< 30 ml/min/1.73 m2. The factors that were related to the variation in tumour markers were albumin and creatinine. The cut-off values of eGFR were 59.7 ml/min/1.73 m2 for SCC-Ag and 63.6 ml/min/1.73 m2 for CYFRA, and the cut-off age when the tumour markers might rise due to the effect of renal function were 72 years for SCC-Ag and 73 years for CYFRA. In conclusion, decreased renal function should be taken into account when evaluating tumour markers in oral cancer. In addition, tumour markers are likely to be overestimated in patients over the age of 72?73 years.
en-copyright=
kn-copyright=

en-aut-name=ObataK.
en-aut-sei=Obata
en-aut-mei=K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YutoriH.
en-aut-sei=Yutori
en-aut-mei=H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YoshidaK.
en-aut-sei=Yoshida
en-aut-mei=K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SakamotoY.
en-aut-sei=Sakamoto
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OnoK.
en-aut-sei=Ono
en-aut-mei=K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IbaragiS.
en-aut-sei=Ibaragi
en-aut-mei=S.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Oral cancer
kn-keyword=Oral cancer
en-keyword=Tumor markers
kn-keyword=Tumor markers
en-keyword=Squamous cell carcinoma
kn-keyword=Squamous cell carcinoma
en-keyword=Tumor antigens
kn-keyword=Tumor antigens
en-keyword=CYFRA cytokeratin fragment
kn-keyword=CYFRA cytokeratin fragment
en-keyword=Renal function
kn-keyword=Renal function
END

start-ver=1.4
cd-journal=joma
no-vol=134
cd-vols=
no-issue=3
article-no=
start-page=171
end-page=175
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20221201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=An in-hospital relapse case of an elderly COVID-19 patient on steroids
kn-title=ステロイド使用中の高齢者に生じたCOVID-19院内再燃症例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　During a pandemic like the novel coronavirus infection 2019 (COVID-19), the availability of inpatient beds is always a major issue. Thus, it is extremely important to release patients from isolation efficiently in order to maintain stable bed operations. However, in clinical practice, patients may develop fever again, before or after the timing specified by the Ministry of Health, Labor and Welfare (MHLW) for lifting isolation, and hence it may be difficult to determine whether the fever is due to a delay in recovery or due to relapse. The diagnosis of relapse is based primarily on the recurrence of symptoms consistent with COVID-19 and a positive PCR result, but few reports have focused on comparing the patterns of variation in two or more blood test findings over the course of the disease. In the present study, we study a case of relapse in an elderly patient on immunosuppressive drugs.<br>
　Understanding the unique patterns of variability between baseline blood test values and acute infection test values in each individual patient may serve as an adjunctive tool to help diagnose COVID-19 relapse.
en-copyright=
kn-copyright=

en-aut-name=FujitaKoji
en-aut-sei=Fujita
en-aut-mei=Koji
kn-aut-name=藤田浩二
kn-aut-sei=藤田
kn-aut-mei=浩二
aut-affil-num=1
ORCID=

en-aut-name=OchoKazuki
en-aut-sei=Ocho
en-aut-mei=Kazuki
kn-aut-name=大重和樹
kn-aut-sei=大重
kn-aut-mei=和樹
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of General Internal Medicine and Infectious Diseases, Tsuyama Chuo Hospital
kn-affil=津山中央病院　総合内科・感染症内科

affil-num=2
en-affil=Department of Internal Medicine, Ishikawa Hospital
kn-affil=石川病院　内科
en-keyword=再燃（relapse）
kn-keyword=再燃（relapse）
en-keyword=新型コロナウイルス感染症（COVID-19）
kn-keyword=新型コロナウイルス感染症（COVID-19）
en-keyword=高齢者（elderly）
kn-keyword=高齢者（elderly）
en-keyword=ステロイド（steroids）
kn-keyword=ステロイド（steroids）
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=6
article-no=
start-page=1150
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Taste Responses and Ingestive Behaviors to Ingredients of Fermented Milk in Mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Fermented milk is consumed worldwide because of its nutritious and healthful qualities. Although it is somewhat sour, causing some to dislike it, few studies have examined taste aspects of its ingredients. Wild-type mice and T1R3-GFP-KO mice lacking sweet/umami receptors were tested with various taste components (sucrose, galactose, lactose, galacto-oligosaccharides, fructo-oligosaccharides, l- and d-lactic acid) using 48 h two-bottle tests and short-term lick tests. d-lactic acid levels were measured after the ingestion of d- or; l-lactic acid or water to evaluate d-lactic acidosis. In wild-type mice, for the sweet ingredients the number of licks increased in a concentration-dependent manner, but avoidance was observed at higher concentrations in 48 h two-bottle tests; the sour ingredients d- and l-lactic acid showed concentration-dependent decreases in preference in both short- and long-term tests. In 48 h two-bottle tests comparing d- and l-lactic acid, wild-type but not T1R3-GFP-KO mice showed higher drinking rates for l-lactic acid. d-lactic acidosis did not occur and thus did not contribute to this preference. These results suggest that intake in short-term lick tests varied by preference for each ingredient, whereas intake variation in long-term lick tests reflects postingestive effects. l-lactic acid may have some palatable taste in addition to sour taste.
en-copyright=
kn-copyright=

en-aut-name=YamaseYuko
en-aut-sei=Yamase
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HuangHai
en-aut-sei=Huang
en-aut-mei=Hai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MitohYoshihiro
en-aut-sei=Mitoh
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=EgusaMasahiko
en-aut-sei=Egusa
en-aut-mei=Masahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MiyawakiTakuya
en-aut-sei=Miyawaki
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YoshidaRyusuke
en-aut-sei=Yoshida
en-aut-mei=Ryusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Dental Anesthesiology and Special Care Dentistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Dental Anesthesiology and Special Care Dentistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Dental Anesthesiology and Special Care Dentistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=postingestive effects
kn-keyword=postingestive effects
en-keyword=galactose
kn-keyword=galactose
en-keyword=lactose
kn-keyword=lactose
en-keyword=oligosaccharides
kn-keyword=oligosaccharides
en-keyword=lactic acid
kn-keyword=lactic acid
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=1
article-no=
start-page=45
end-page=55
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202302
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Image Quality Assessment of Deep Learning Image Reconstruction in Torso Computed Tomography Using Tube Current Modulation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Novel deep learning image reconstruction (DLIR) reportedly changes the image quality characteristics based on object contrast and image noise. In clinical practice, computed tomography image noise is usually controlled by tube current modulation (TCM) to accommodate changes in object size. This study aimed to evaluate the image quality characteristics of DLIR for different object sizes when the in-plane noise was controlled by TCM. Images acquisition was performed on a GE Revolution CT system to investigate the impact of the DLIR algorithm compared to the standard reconstructions of filtered-back projection (FBP) and hybrid iterative reconstruction (hybrid-IR). The image quality assessment was performed using phantom images, and an observer study was conducted using clinical cases. The image quality assessment confirmed the excellent noise- reduction performance of DLIR, despite variations due to phantom size. Similarly, in the observer study, DLIR received high evaluations regardless of the body parts imaged. We evaluated a novel DLIR algorithm by replicating clinical behaviors. Consequently, DLIR exhibited higher image quality than those of FBP and hybrid-IR in both phantom and observer studies, albeit the value depended on the reconstruction strength, and proved itself capable of providing stable image quality in clinical use.
en-copyright=
kn-copyright=

en-aut-name=TakeuchiKazuhiro
en-aut-sei=Takeuchi
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IdeYasuhiro
en-aut-sei=Ide
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MoriYuichiro
en-aut-sei=Mori
en-aut-mei=Yuichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UeharaYusuke
en-aut-sei=Uehara
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SukeishiHiroshi
en-aut-sei=Sukeishi
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=GotoSachiko
en-aut-sei=Goto
en-aut-mei=Sachiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Radiology, Kagawa University Hospital
kn-affil=

affil-num=2
en-affil=Department of Radiology, Kagawa University Hospital
kn-affil=

affil-num=3
en-affil=Department of Radiology, Kagawa University Hospital
kn-affil=

affil-num=4
en-affil=Department of Radiology, Kagawa University Hospital
kn-affil=

affil-num=5
en-affil=Department of Radiology, Kagawa University Hospital
kn-affil=

affil-num=6
en-affil=Department of Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=
en-keyword=computed tomography
kn-keyword=computed tomography
en-keyword=deep learning
kn-keyword=deep learning
en-keyword=image reconstruction
kn-keyword=image reconstruction
en-keyword=tube current modulation
kn-keyword=tube current modulation
en-keyword=object size
kn-keyword=object size
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=1
article-no=
start-page=53
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20221227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Reliability of the Garden Alignment Index and Valgus Tilt Measurement for Nondisplaced Femoral Neck Fractures
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Anteroposterior (AP) alignment assessment for nondisplaced femoral neck fractures is important for determining the treatment strategy and predicting postoperative outcomes. AP alignment is generally measured using the Garden alignment index (GAI). However, its reliability remains unknown. We compared the reliability of GAI and a new AP alignment measurement (valgus tilt measurement [VTM]) using preoperative AP radiographs of nondisplaced femoral neck fractures. The study was designed as an intra- and inter-rater reliability analysis. The raters were four trauma surgeons who assessed 50 images twice. The main outcome was the intraclass correlation coefficient (ICC). To calculate intra- and inter-rater reliability, we used a mixed-effects model considering rater, patient, and time. The overall ICC (95% CI) of GAI and VTM for intra-rater reliability was 0.92 (0.89-0.94) and 0.86 (0.82-0.89), respectively. The overall ICC of GAI and VTM for inter-rater reliability was 0.92 (0.89-0.95), and 0.85 (0.81-0.88), respectively. The intra- and inter-rater reliability of GAI was higher in patients aged <80 years than in patients aged >= 80 years. Our results showed that GAI is a more reliable measurement method than VTM, although both are reliable. Variations in patient age should be considered in GAI measurements.
en-copyright=
kn-copyright=

en-aut-name=YamakawaYasuaki
en-aut-sei=Yamakawa
en-aut-mei=Yasuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamamotoNorio
en-aut-sei=Yamamoto
en-aut-mei=Norio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TomitaYosuke
en-aut-sei=Tomita
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OkudaRyuichiro
en-aut-sei=Okuda
en-aut-mei=Ryuichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MasadaYasutaka
en-aut-sei=Masada
en-aut-mei=Yasutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ShiroshitaAkihiro
en-aut-sei=Shiroshita
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MatsumotoToshiyuki
en-aut-sei=Matsumoto
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Orthopedic Surgery, Kochi Health Sciences Center
kn-affil=

affil-num=2
en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Physical Therapy, Faculty of Health Care, Takasaki University of Health and Welfare
kn-affil=

affil-num=4
en-affil=Department of Orthopedic Surgery, Kochi Health Sciences Center
kn-affil=

affil-num=5
en-affil=Department of Orthopedic Surgery, Kochi Health Sciences Center
kn-affil=

affil-num=6
en-affil=Scientific Research Works Peer Support Group (SRWS-PSG)
kn-affil=

affil-num=7
en-affil=Department of Orthopedic Surgery, Kochi Health Sciences Center
kn-affil=
en-keyword=femoral neck fracture
kn-keyword=femoral neck fracture
en-keyword=intracapsular hip fracture
kn-keyword=intracapsular hip fracture
en-keyword=Garden alignment index
kn-keyword=Garden alignment index
en-keyword=posterior tilt
kn-keyword=posterior tilt
en-keyword=inter-rater reliability
kn-keyword=inter-rater reliability
en-keyword=intra-rater reliability
kn-keyword=intra-rater reliability
en-keyword=intraclass correlation coefficients
kn-keyword=intraclass correlation coefficients
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=1
article-no=
start-page=497
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20221228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Interspecific Variability in Growth Characteristics and Phytoremediation of Cu by Free-Floating Azolla Macrophytes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The phytoremediation potential of aquatic plants, particularly for Cu, is scarcely reported in the pertinent literature. In this regard, differential growth behavior and phytoaccumulation ability of three free-floating Azolla species (A. japonica, A. pinnata, and A. hybrid) were evaluated in a climatically controlled (a temperature of 25/20 degrees C, light/dark 16/8 h, a light intensity of 60 mu mol m(-2) s(-1), and a relative humidity of 65%) microcosm study. Azolla plants were exposed to solutions having three Cu concentrations (0, 3, and 6 mg L-1) under two incubation periods (4 and 8 days). Different Cu treatments significantly reduced Azolla biomass during both incubation periods and A. pinnata was the most sensitive species. Azolla plants grown in aqueous solutions showed substantial variations in Cu removal capacity. Higher bioconcentration values displayed by Azolla plants indicated that these plants can be deployed as potential plants for Cu removal from Cu contaminated water. Nevertheless, the plants exposed to higher Cu concentrations displayed color changes and root detachment due to Cu phytotoxic effects which may also ultimately lead to plant death. Significant correlations between Cu removed from the aqueous solutions and Cu contents of plant biomass indicated that Cu phytoremediation by Azolla plants was due to the phytoaccumulation mechanism because the removed Cu from aqueous solutions was accumulated in plant biomass. Introduced Azolla species, i.e., A. hybrid, displayed comparable Cu removal efficiency with naturally grown Azolla species, i.e., A. japonica and A. pinnata. Tested Azolla species proved to be suitable candidates to remediate Cu contaminated water and can be deployed for phytoremediation.
en-copyright=
kn-copyright=

en-aut-name=AkhtarMuhammad Shahbaz
en-aut-sei=Akhtar
en-aut-mei=Muhammad Shahbaz
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AslamSohaib
en-aut-sei=Aslam
en-aut-mei=Sohaib
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=DittaAllah
en-aut-sei=Ditta
en-aut-mei=Allah
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AlbalawiBedur Faleh A.
en-aut-sei=Albalawi
en-aut-mei=Bedur Faleh A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OkiYoko
en-aut-sei=Oki
en-aut-mei=Yoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NakashimaYoshitaka
en-aut-sei=Nakashima
en-aut-mei=Yoshitaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Environmental Sciences, Forman Christian College University
kn-affil=

affil-num=2
en-affil=Department of Environmental Sciences, Forman Christian College University
kn-affil=

affil-num=3
en-affil=Department of Environmental Sciences, Shaheed Benazir Bhutto University
kn-affil=

affil-num=4
en-affil=Department of Biology, University of Tabuk
kn-affil=

affil-num=5
en-affil=Department of Environmental Management Engineering, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Environmental Management Engineering, Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=Azolla biomass
kn-keyword=Azolla biomass
en-keyword=bioconcentration factor
kn-keyword=bioconcentration factor
en-keyword=Cu removal efficiency
kn-keyword=Cu removal efficiency
en-keyword=Cu toxicity
kn-keyword=Cu toxicity
en-keyword=translocation factor
kn-keyword=translocation factor
END

start-ver=1.4
cd-journal=joma
no-vol=17
cd-vols=
no-issue=8
article-no=
start-page=e0273330
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220818
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Intraspecies variation of the mitochondrial genome: An evaluation for phylogenetic approaches based on the conventional choices of genes and segments on mitogenome
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Intraspecies nucleotide sequence variation is a key to understanding the evolutionary history of a species, such as the geographic distribution and population structure. To date, numerous phylogenetic and population genetics studies have been conducted based on the sequences of a gene or an intergenic region on the mitochondrial genome (mtDNA), such as cytochrome c oxidase subunits or the D-loop. To evaluate the credibility of the usage of such 'classic' markers, we compared the phylogenetic inferences based on the analyses of the partial and entire mtDNA sequences. Importantly, the phylogenetic reconstruction based on the short marker sequences did not necessarily reproduce the tree topologies based on the analyses of the entire mtDNA. In addition, analyses on the datasets of various organisms revealed that the analyses based on the classic markers yielded phylogenetic trees with poor confidence in all tested cases compared to the results based on full-length mtDNA. These results demonstrated that phylogenetic analyses based on complete mtDNA sequences yield more insightful results compared to those based on mitochondrial genes and segments. To ameliorate the shortcomings of the classic markers, we identified a segment of mtDNA that may be used as an 'approximate marker' to closely reproduce the phylogenetic inference obtained from the entire mtDNA in the case of mammalian species, which can be utilized to design amplicon-seq-based studies. Our study demonstrates the importance of the choice of mitochondrial markers for phylogenetic analyses and proposes a novel approach to choosing appropriate markers for mammalian mtDNA that reproduces the phylogenetic inferences obtained from full-length mtDNA.
en-copyright=
kn-copyright=

en-aut-name=Mor?n-L?pezJes?s
en-aut-sei=Mor?n-L?pez
en-aut-mei=Jes?s
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=VergaraKaren
en-aut-sei=Vergara
en-aut-mei=Karen
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SatoMasanao
en-aut-sei=Sato
en-aut-mei=Masanao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=GajardoGonzalo
en-aut-sei=Gajardo
en-aut-mei=Gonzalo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=UekiShoko
en-aut-sei=Ueki
en-aut-mei=Shoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil=Laboratorio de Gen?tica, Acuicultura & Biodiversidad, Departamento de Ciencias Biol?gicas y Biodiversidad, Universidad de Los Lagos
kn-affil=

affil-num=3
en-affil=Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
kn-affil=

affil-num=4
en-affil=Laboratorio de Gen?tica, Acuicultura & Biodiversidad, Departamento de Ciencias Biol?gicas y Biodiversidad, Universidad de Los Lagos
kn-affil=

affil-num=5
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=6
article-no=
start-page=673
end-page=678
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Handling of Germline Findings in Clinical Comprehensive Cancer Genomic Profiling
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Patients found to have presumed germline pathogenic variants (PGPVs) during comprehensive genomic profiling (CGP) require genetic counseling (GC) referrals. We retrospectively investigated the outcomes of patients with PGPVs. Among 159 patients who underwent CGP, we recommended GC for the 16 patients with PGPVs (3 with [FG group] and 13 without [G Group] a family/personal history of hereditary cancer) as well as for the 8 patients with no PGPVs, but a history (F group); 2 (67%), 5 (38%), and 3 (38%) patients received GC in the FG, G, and F groups, respectively. Germline testing results were positive in 1 and 2 patients of the FG and G groups, respectively. Among the patients recommended for GC, 58% did not receive GC due to lack of interest, poor performance status, or death. CGP contributes to the identification of germline variants in patients without a history of hereditary cancer. However, the proportion of patients who undergo GC should be improved.
en-copyright=
kn-copyright=

en-aut-name=Okazawa-SakaiMika
en-aut-sei=Okazawa-Sakai
en-aut-mei=Mika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamamotoYasuko
en-aut-sei=Yamamoto
en-aut-mei=Yasuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FutagawaMashu
en-aut-sei=Futagawa
en-aut-mei=Mashu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OkamuraMiki
en-aut-sei=Okamura
en-aut-mei=Miki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MiyawakiSatoko
en-aut-sei=Miyawaki
en-aut-mei=Satoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NishinaTomohiro
en-aut-sei=Nishina
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakeharaKazuhiro
en-aut-sei=Takehara
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KozukiToshiyuki
en-aut-sei=Kozuki
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TomidaShuta
en-aut-sei=Tomida
en-aut-mei=Shuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=HyodoIchinosuke
en-aut-sei=Hyodo
en-aut-mei=Ichinosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OhsumiShozo
en-aut-sei=Ohsumi
en-aut-mei=Shozo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=HirasawaAkira
en-aut-sei=Hirasawa
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cancer Genomic Medicine, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=3
en-affil=Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Hereditary Tumors, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=5
en-affil=Department of Cancer Genomic Medicine, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=6
en-affil=Department of Cancer Genomic Medicine, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=7
en-affil=Department of Gynecologic Oncology, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=8
en-affil=Department of Clinical Research Center, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=9
en-affil=Center for Comprehensive Genomic Medicine, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Cancer Genomic Medicine, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=11
en-affil=Department of Hereditary Tumors, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=12
en-affil=Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=comprehensive genomic profiling
kn-keyword=comprehensive genomic profiling
en-keyword=hereditary cancer
kn-keyword=hereditary cancer
en-keyword=germline findings
kn-keyword=germline findings
en-keyword=presumed germline pathogenic variant(s)
kn-keyword=presumed germline pathogenic variant(s)
en-keyword=genetic counseling
kn-keyword=genetic counseling
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220922
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=現生サンゴ骨格中の地球化学的トレーサーに基づくインドネシア多島海表層環境の時空間的変動の復元
kn-title=Reconstructions of temporal and spatial variations in surface conditions of the Indonesian Seas based on geochemical tracers in modern coral skeletons
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=GENDAAi
en-aut-sei=GENDA
en-aut-mei=Ai
kn-aut-name=源田亜衣
kn-aut-sei=源田
kn-aut-mei=亜衣
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama university
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=5
article-no=
start-page=585
end-page=591
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Surgery Outcomes for Pulmonary Metastases from Renal Cell Carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Pulmonary metastatic resection is a standard therapy for renal cell carcinoma (RCC). Although patients with pulmonary metastases who do not undergo any treatment have poor prognoses, it has been reported that resection for pulmonary metastases yields good clinical outcomes. We investigated the prognoses of the 10 Japanese patients (eight males, two females) who underwent a surgical resection of pulmonary metastasectomy from RCC at our institution between April 1, 2012 and March 31, 2020 and analyzed the prognostic factors. We determined the prognoses and calculated the 5-year overall survival (OS) and disease-free survival (DFS) rates. To identify prognostic factors, we compared the median DFS duration for each factor. Elderly patients (median age, 75.5 years) were more predominant compared to previous studies, and all 10 patients underwent a complete resection. The 5-year DFS rate was 30.5% (95%CI: 0.045-0.63) and the 5-year OS rate was 80% (95%CI: 0.20-0.97). The following factors were associated with better prognosis: female, disease-free interval?36 months, and metastases size<12 mm. These results indicate that complete resection for pulmonary metastases from RCC resulted in good clinical outcomes, particularly for patients with better prognostic factors.
en-copyright=
kn-copyright=

en-aut-name=ChoshiHaruki
en-aut-sei=Choshi
en-aut-mei=Haruki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WatanabeMototsugu
en-aut-sei=Watanabe
en-aut-mei=Mototsugu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FurukawaShinichi
en-aut-sei=Furukawa
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UjikeHiroyuki
en-aut-sei=Ujike
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KataokaKazuhiko
en-aut-sei=Kataoka
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Thoracic Surgery, National Hospital Organization Iwakuni Clinical Center
kn-affil=

affil-num=2
en-affil=Department of Thoracic Surgery, National Hospital Organization Iwakuni Clinical Center
kn-affil=

affil-num=3
en-affil=Department of Thoracic Surgery, National Hospital Organization Iwakuni Clinical Center
kn-affil=

affil-num=4
en-affil=Department of Thoracic Surgery, National Hospital Organization Iwakuni Clinical Center
kn-affil=

affil-num=5
en-affil=Department of Thoracic Surgery, National Hospital Organization Iwakuni Clinical Center
kn-affil=
en-keyword=renal cell carcinoma
kn-keyword=renal cell carcinoma
en-keyword=pulmonary metastasis
kn-keyword=pulmonary metastasis
en-keyword=complete resection
kn-keyword=complete resection
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=5
article-no=
start-page=527
end-page=533
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Serum 1,25-dihydroxyvitamin D3 Levels in Patients with Eosinophilic Chronic Rhinosinusitis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MakiharaSeiichiro
en-aut-sei=Makihara
en-aut-mei=Seiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KariyaShin
en-aut-sei=Kariya
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MiyamotoShotaro
en-aut-sei=Miyamoto
en-aut-mei=Shotaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UraguchiKensuke
en-aut-sei=Uraguchi
en-aut-mei=Kensuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OkaAiko
en-aut-sei=Oka
en-aut-mei=Aiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TsumuraMunechika
en-aut-sei=Tsumura
en-aut-mei=Munechika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NodaYohei
en-aut-sei=Noda
en-aut-mei=Yohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=AndoMizuo
en-aut-sei=Ando
en-aut-mei=Mizuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OkanoMitsuhiro
en-aut-sei=Okano
en-aut-mei=Mitsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Otolaryngology-Head & Neck Surgery, Kagawa Rosai Hospital
kn-affil=

affil-num=4
en-affil=Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Otorhinolaryngology, International University of Health and Welfare, School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Otolaryngology-Head & Neck Surgery, Kagawa Rosai Hospital
kn-affil=

affil-num=7
en-affil=Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Otorhinolaryngology, International University of Health and Welfare, School of Medicine
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=5
article-no=
start-page=519
end-page=526
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Gestational Outcomes and Birth Weight in Japanese Women at the Upper and Lower limits of the Normal BMI range
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To examine the outcome of gestational blood pressure and birth weight in women with normal pre-pregnancy BMI (18.5-25 kg/m2) who are at the lower and upper limits of this range, i.e., slightly underweight or slightly overweight. Overall, 2,038 Japanese women with low -risk who had delivered during January 2014?December 2016 were classified according to their pre-pregnancy BMI: underweight (< 18.5 kg/m2), slightly underweight (18.5?BMI<21 kg/m2), normal (21?BMI<23 kg/m2), slightly overweight (23?BMI<25 kg/m2) and overweight (? 25 kg/m2). Their blood pressure during each trimester and birth weight was evaluated. The slightly overweight group showed a significantly higher blood pressure than the underweight and slightly underweight groups. Birth weight was lower in the slightly underweight than in the slightly overweight group (p<0.01). The incidence rate of “heavy for dates” (HFD) infants was significantly higher in the slightly overweight and overweight groups than in the other groups (p<0.05 and p<0.01, respectively). Weight gain of < 7 kg significantly increased the rate of “light for dates” (LFD) infants, while a weight gain of ?13 kg significantly increased the rate of HFD infants (p<0.05 and p<0.01, respectively). Blood pressure during pregnancy was ssociated with pre-pregnancy BMI. The birth weight of infants of low-risk pregnant women is affected by both pre-pregnancy BMI and gestational weight gain.
en-copyright=
kn-copyright=

en-aut-name=IshiokaYoko
en-aut-sei=Ishioka
en-aut-mei=Yoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamashitaHiroyuki
en-aut-sei=Yamashita
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HamaguchiKinya
en-aut-sei=Hamaguchi
en-aut-mei=Kinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KuwaharaYoshitaka
en-aut-sei=Kuwahara
en-aut-mei=Yoshitaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakamuraKaoru
en-aut-sei=Nakamura
en-aut-mei=Kaoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NakatsukaMikiya
en-aut-sei=Nakatsuka
en-aut-mei=Mikiya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Yamaguchi Rosai Hospital
kn-affil=

affil-num=3
en-affil=Hamaguchi Women's Clinic
kn-affil=

affil-num=4
en-affil=Kuwahara Obstetrics and Gynecology Clinic
kn-affil=

affil-num=5
en-affil=Okinawa Kyoudou Hospital
kn-affil=

affil-num=6
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
en-keyword=birth weight
kn-keyword=birth weight
en-keyword=blood pressure
kn-keyword=blood pressure
en-keyword=normal body weight
kn-keyword=normal body weight
en-keyword=pregnancy pre-pregnancy BMI
kn-keyword=pregnancy pre-pregnancy BMI
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=5
article-no=
start-page=489
end-page=502
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Current Insights into Mesenchymal Signatures in Glioblastoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives.
en-copyright=
kn-copyright=

en-aut-name=MatsumotoYuji
en-aut-sei=Matsumoto
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IchikawaTomotsugu
en-aut-sei=Ichikawa
en-aut-mei=Tomotsugu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KurozumiKazuhiko
en-aut-sei=Kurozumi
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=DateIsao
en-aut-sei=Date
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Neurological Surgery, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=3
en-affil=Department of Neurosurgery, Hamamatsu University Hospital
kn-affil=

affil-num=4
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=glioma
kn-keyword=glioma
en-keyword=glioblastoma
kn-keyword=glioblastoma
en-keyword=mesenchymal subtype
kn-keyword=mesenchymal subtype
en-keyword=mesenchymal transition
kn-keyword=mesenchymal transition
en-keyword=heterogeneity
kn-keyword=heterogeneity
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=41
article-no=
start-page=e30997
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20221014
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Endoscopic findings of gastric neoplasms in familial adenomatous polyposis are associated with the phenotypic variations and grades of dysplasia
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Patients with familial adenomatous polyposis (FAP) are at increased risk of developing gastric neoplasms. However, endoscopic findings have not been sufficiently investigated. We investigated the phenotypic expression of gastric adenoma (low-grade dysplasia) and gastric cancer (high-grade dysplasia or carcinoma) in patients with FAP and clarified their relationships to endoscopic findings. Of 29 patients with FAP who underwent esophagogastroduodenoscopy between 2005 and 2020, 11 (38%) had histologically confirmed gastric neoplasms, including 23 lesions of gastric adenoma and 9 lesions of gastric cancer. The gastric neoplasms were classified into 3 phenotypes (gastric, mixed, or intestinal type) according to the immunostaining results and evaluated for location (U or M region: upper or middle third of the stomach or L region: lower third of the stomach), color (same as the background mucosa, whitish, or reddish), macroscopic type (elevated, flat, or depressed), background mucosal atrophy (present or absent), fundic gland polyps in the surrounding mucosa (present or absent), and morphologic changes in tumor size. Elevated whitish gastric adenomas were further subdivided by macroscopic type (flat elevated, protruded, or elevated with a central depression) and color (milky- or pinkish-white). The gastric adenomas included gastric (11/23, 48%), mixed (4/23, 17%), and intestinal (8/23, 35%) phenotypes. In contrast, no lesions of gastric cancers showed a gastric phenotype (0/9, 0%), while 5 (56%) and 4 (44%) lesions were intestinal and mixed phenotypes, respectively. Gastric cancers were significantly more likely than gastric adenomas to present as reddish depressed lesions with gastric atrophy. All gastric-type adenomas occurred in non-atrophic mucosa, in mucosa with fundic gland polyps in the periphery, in the U or M region, and as flat elevated or protruded lesions with a milky-white color. Half of the lesions increased in size. Meanwhile, the typical endoscopic features of intestinal-type adenomas included occurrence in the L region and elevated pinkish-white lesions with central depression. None of the intestinal-type adenomas increased in size during the observation period. We believe that these endoscopic features will be useful for the prompt diagnosis and appropriate management of gastric neoplasms in patients with FAP.
en-copyright=
kn-copyright=

en-aut-name=KobashiMayu
en-aut-sei=Kobashi
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IwamuroMasaya
en-aut-sei=Iwamuro
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KuraokaSakiko
en-aut-sei=Kuraoka
en-aut-mei=Sakiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=InooShoko
en-aut-sei=Inoo
en-aut-mei=Shoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OkanoueShotaro
en-aut-sei=Okanoue
en-aut-mei=Shotaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SatomiTakuya
en-aut-sei=Satomi
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HamadaKenta
en-aut-sei=Hamada
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=AbeMakoto
en-aut-sei=Abe
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KonoYoshiyasu
en-aut-sei=Kono
en-aut-mei=Yoshiyasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KanzakiHiromitsu
en-aut-sei=Kanzaki
en-aut-mei=Hiromitsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KawanoSeiji
en-aut-sei=Kawano
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KawaharaYoshiro
en-aut-sei=Kawahara
en-aut-mei=Yoshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate  School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate  School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate  School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate  School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate  School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate  School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate  School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate  School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate  School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate  School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate  School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of Pathology, Okayama University Graduate School of Medicine,  Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=13
en-affil=Department of  Practical Gastrointestinal Endoscopy, Okayama University Graduate School of  Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=14
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate  School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=familial adenomatous polyposis
kn-keyword=familial adenomatous polyposis
en-keyword=gastric adenoma
kn-keyword=gastric adenoma
en-keyword=gastric cancer
kn-keyword=gastric cancer
en-keyword=phenotypic variations
kn-keyword=phenotypic variations
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=4
article-no=
start-page=385
end-page=390
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202208
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Perioperative Clinical Course Variables Associated with Length of Hospital Stay after Primary Intracranial Meningioma Resection
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The relationship between perioperative clinical course variables and postoperative length of hospital stay (LOS) in patients undergoing primary intracranial meningioma resection has not been fully elucidated. We therefore aimed to identify the perioperative clinical course variables that predict postoperative LOS in such patients. We retrospectively collected data concerning demographics, tumor characteristics, and perioperative clinical course variables in 76 patients who underwent primary intracranial meningioma resection between January 2010 and December 2019, and tested for associations with postoperative LOS. Univariate analyses showed that younger age, fewer days to postoperative initiation of standing/walking, preoperative independence in activities of daily living (ADL), and ADL independence one week after surgery were associated with shorter postoperative LOS. Multiple regression analyses with these factors identified that days to stand/walk initiation and ADL independence one week after surgery were associated with postoperative LOS. Based on these results, we conclude that rehabilitation programs that promote early mobilization and the early acquisition of independence may reduce postoperative LOS in patients who undergo primary intracranial meningioma resection.
en-copyright=
kn-copyright=

en-aut-name=ManabeTomotaka
en-aut-sei=Manabe
en-aut-mei=Tomotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MiyakeKeisuke
en-aut-sei=Miyake
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KajiYoshio
en-aut-sei=Kaji
en-aut-mei=Yoshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NinomiyaKento
en-aut-sei=Ninomiya
en-aut-mei=Kento
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujitaChiaki
en-aut-sei=Fujita
en-aut-mei=Chiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TanakaShouichi
en-aut-sei=Tanaka
en-aut-mei=Shouichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MoritaShin
en-aut-sei=Morita
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TamiyaTakashi
en-aut-sei=Tamiya
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YamamotoTetsuji
en-aut-sei=Yamamoto
en-aut-mei=Tetsuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Rehabilitation, Kagawa University Hospital
kn-affil=

affil-num=2
en-affil=Department of Neurological Surgery, Faculty of Medicine, Kagawa University
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Faculty of Medicine, Kagawa University
kn-affil=

affil-num=4
en-affil=Department of Rehabilitation, Kagawa University Hospital
kn-affil=

affil-num=5
en-affil=Department of Division of Clinical Nutrition, Faculty of Medicine, Kagawa University
kn-affil=

affil-num=6
en-affil=Department of Rehabilitation, Kagawa University Hospital
kn-affil=

affil-num=7
en-affil=Department of Rehabilitation, Kagawa University Hospital
kn-affil=

affil-num=8
en-affil=Department of Neurological Surgery, Faculty of Medicine, Kagawa University
kn-affil=

affil-num=9
en-affil=Department of Rehabilitation, Kagawa University Hospital
kn-affil=
en-keyword=early mobilization
kn-keyword=early mobilization
en-keyword=functional independence
kn-keyword=functional independence
en-keyword=perioperative clinical course
kn-keyword=perioperative clinical course
en-keyword=length of hospital stay
kn-keyword=length of hospital stay
en-keyword=meningioma
kn-keyword=meningioma
END

start-ver=1.4
cd-journal=joma
no-vol=23
cd-vols=
no-issue=15
article-no=
start-page=8626
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220803
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Candidate Genes in Testing Strategies for Linkage Analysis and Bioinformatic Sorting of Whole Genome Sequencing Data in Three Small Japanese Families with Idiopathic Superior Oblique Muscle Palsy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Idiopathic superior oblique muscle palsy is a major type of paralytic, non-comitant strabismus and presents vertical and cyclo-torsional deviation of one eye against the other eye, with a large vertical fusion range and abnormal head posture such as head tilt. Genetic background is considered to play a role in its development, as patients with idiopathic superior oblique muscle palsy have varying degrees of muscle hypoplasia and, rarely, the complete absence of the muscle, that is, aplasia. In this study, whole genome sequencing was performed, and single nucleotide variations and short insertions/deletions (SNVs/InDels) were annotated in two patients each in three small families (six patients in total) with idiopathic superior oblique muscle palsy, in addition to three normal individuals in one family. At first, linkage analysis was carried out in the three families and SNVs/InDels in chromosomal loci with negative LOD scores were excluded. Next, SNVs/InDels shared by the six patients, but not by the three normal individuals, were chosen. SNVs/InDels were further narrowed down by choosing low-frequency (&lt;1%) or non-registered SNVs/InDels in four databases for the Japanese population, and then by choosing SNVs/InDels with functional influence, leading to one candidate gene, SSTR5-AS1 in chromosome 16. The six patients were heterozygous for 13-nucleotide deletion in SSTR5-AS1, except for one homozygous patient, while the three normal individuals were wild type. Targeted polymerase chain reaction (PCR) and direct sequencing of PCR products confirmed the 13-nucleotide deletion in SSTR5-AS1. In the face of newly-registered SSTR5-AS1 13-nucleotide deletion at a higher frequency in a latest released database for the Japanese population, the skipping of low-frequency and non-registration sorting still resulted in only 13 candidate genes including SSTR5-AS1 as common variants. The skipping of linkage analysis also led to the same set of 13 candidate genes. Different testing strategies that consisted of linkage analysis and simple unintentional bioinformatics could reach candidate genes in three small families with idiopathic superior oblique muscle palsy.
en-copyright=
kn-copyright=

en-aut-name=MatsuoToshihiko
en-aut-sei=Matsuo
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=Chaomulige
en-aut-sei=Chaomulige
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MiyajiMary
en-aut-sei=Miyaji
en-aut-mei=Mary
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HosoyaOsamu
en-aut-sei=Hosoya
en-aut-mei=Osamu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SaitoAkira
en-aut-sei=Saito
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NakazonoKazuyuki
en-aut-sei=Nakazono
en-aut-mei=Kazuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil= Department of Medical Neurobiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil= Department of Medical Neurobiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=StaGen Co., Ltd.
kn-affil=

affil-num=6
en-affil=StaGen Co., Ltd.
kn-affil=
en-keyword=whole genome sequencing
kn-keyword=whole genome sequencing
en-keyword=idiopathic superior oblique muscle palsy
kn-keyword=idiopathic superior oblique muscle palsy
en-keyword=strabismus
kn-keyword=strabismus
en-keyword=esotropia
kn-keyword=esotropia
en-keyword=exotropia
kn-keyword=exotropia
en-keyword=linkage analysis
kn-keyword=linkage analysis
en-keyword=single nucleotide variations and short insertions/deletions
kn-keyword=single nucleotide variations and short insertions/deletions
en-keyword=SNVs/InDels
kn-keyword=SNVs/InDels
en-keyword=SSTR5-AS1
kn-keyword=SSTR5-AS1
en-keyword=bioinformatics
kn-keyword=bioinformatics
en-keyword=muscle hypoplasia (aplasia)
kn-keyword=muscle hypoplasia (aplasia)
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=2
article-no=
start-page=137
end-page=143
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202204
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Changes in Plasma Clozapine Levels after Smoking Cessation in Japanese Inpatients with Schizophrenia: A Retrospective Cohort Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Although reported for Caucasians, changes in plasma clozapine levels after smoking cessation in East Asians remain unclear. We here investigated plasma clozapine levels before and after smoking cessation in Japanese inpatients with schizophrenia. We conducted a retrospective chart review of 14 inpatients with schizophrenia who were being treated with clozapine between June 1, 2019, and July 31, 2019 and who were smokers as of July 1, 2019, the day on which a smoking ban was instituted in the tertiary public psychiatric hospital. The primary outcome was individual differences in plasma clozapine levels between before and after the smoking ban, which were compared using paired t-tests. The mean plasma clozapine level was significantly increased, by 213.4 ng/mL (95% CI 119.9-306.8; p<0.01) or 53.2%. Four of the 14 inpatients experienced clinically significant side effects, such as myoclonus, drooling, and amnesia, due to the development of high plasma clozapine levels. Our findings indicated that close monitoring of plasma clozapine levels before and after smoking cessation and prior dose adjustment of clozapine may be necessary, to prevent a significant risk of developing high plasma clozapine levels, even in Japanese patients.
en-copyright=
kn-copyright=

en-aut-name=TsukaharaMasaru
en-aut-sei=Tsukahara
en-aut-mei=Masaru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SoRyuhei
en-aut-sei=So
en-aut-mei=Ryuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YadaYuji
en-aut-sei=Yada
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KodamaMasafumi
en-aut-sei=Kodama
en-aut-mei=Masafumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KishiYoshiki
en-aut-sei=Kishi
en-aut-mei=Yoshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamadaNorihito
en-aut-sei=Yamada
en-aut-mei=Norihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Psychiatry, Okayama Psychiatric Medical Center
kn-affil=

affil-num=2
en-affil=Department of Psychiatry, Okayama Psychiatric Medical Center
kn-affil=

affil-num=3
en-affil=Department of Psychiatry, Okayama Psychiatric Medical Center
kn-affil=

affil-num=4
en-affil=Department of Psychiatry, Okayama Psychiatric Medical Center
kn-affil=

affil-num=5
en-affil=Department of Psychiatry, Okayama Psychiatric Medical Center
kn-affil=

affil-num=6
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Asian
kn-keyword=Asian
en-keyword=clozapine
kn-keyword=clozapine
en-keyword=schizophrenia
kn-keyword=schizophrenia
en-keyword=smoking
kn-keyword=smoking
END

start-ver=1.4
cd-journal=joma
no-vol=2022
cd-vols=
no-issue=
article-no=
start-page=3157841
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Association of Postprandial Triglyceride Variability with Renal Dysfunction and Microalbuminuria in Patients with Type 2 Diabetic Mellitus: A Retrospective and Observational Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objective. We examined whether or not day-to-day variations in lipid profiles, especially triglyceride (TG) variability, were associated with the exacerbation of diabetic kidney disease. Methods. We conducted a retrospective and observational study. First, 527 patients with type 2 diabetes mellitus (DM) who had had their estimated glomerular filtration rate (eGFR) checked every 6 months since 2012 for over 5 years were registered. Variability in postprandial TG was determined using the standard deviation (SD), SD adjusted (Adj-SD) for the number of measurements, and maximum minus minimum difference (MMD) during the first three years of follow-up. The endpoint was a & GE;40% decline from baseline in the eGFR, initiation of dialysis or death. Next, 181 patients who had no micro- or macroalbuminuria in February 2013 were selected from among the 527 patients for an analysis. The endpoint was the incidence of microalbuminuria, initiation of dialysis, or death. Results. Among the 527 participants, 110 reached a & GE;40% decline from baseline in the eGFR or death. The renal survival was lower in the higher-SD, higher-Adj-SD, and higher-MMD groups than in the lower-SD, lower-Adj-SD, and lower-MMD groups, respectively (log-rank test p=0.0073, 0.0059, and 0.0195, respectively). A lower SD, lower Adj-SD, and lower MMD were significantly associated with the renal survival in the adjusted model (hazard ratio, 1.62, 1.66, 1.59; 95% confidence intervals, 1.05-2.53, 1.08-2.58, 1.04-2.47, respectively). Next, among 181 participants, 108 developed microalbuminuria or death. The nonincidence of microalbuminuria was lower in the higher-SD, higher-Adj-SD, and higher-MMD groups than in the lower-SD, lower-Adj-SD, and lower-MMD groups, respectively (log-rank test p=0.0241, 0.0352, and 0.0474, respectively). Conclusions. Postprandial TG variability is a novel risk factor for eGFR decline and the incidence of microalbuminuria in patients with type 2 DM.
en-copyright=
kn-copyright=

en-aut-name=Matsuoka-UchiyamaNatsumi
en-aut-sei=Matsuoka-Uchiyama
en-aut-mei=Natsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UchidaHaruhito A.
en-aut-sei=Uchida
en-aut-mei=Haruhito A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkamotoShugo
en-aut-sei=Okamoto
en-aut-mei=Shugo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OnishiYasuhiro
en-aut-sei=Onishi
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KatayamaKatsuyoshi
en-aut-sei=Katayama
en-aut-mei=Katsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=Tsuchida-NishiwakiMariko
en-aut-sei=Tsuchida-Nishiwaki
en-aut-mei=Mariko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakeuchiHidemi
en-aut-sei=Takeuchi
en-aut-mei=Hidemi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakemotoRika
en-aut-sei=Takemoto
en-aut-mei=Rika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=HadaYoshiko
en-aut-sei=Hada
en-aut-mei=Yoshiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=UmebayashiRyoko
en-aut-sei=Umebayashi
en-aut-mei=Ryoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KurookaNaoko
en-aut-sei=Kurooka
en-aut-mei=Naoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=TsujiKenji
en-aut-sei=Tsuji
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=EguchiJun
en-aut-sei=Eguchi
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=NakajimaHirofumi
en-aut-sei=Nakajima
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=ShikataKenichi
en-aut-sei=Shikata
en-aut-mei=Kenichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

affil-num=1
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Chronic Kidney Disease and Cardiovascular Disease, Okayama University Academic Field of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=13
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=14
en-affil=Nakashima Hospital
kn-affil=

affil-num=15
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=16
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=369
cd-vols=
no-issue=1
article-no=
start-page=fnac019
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=2022
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Heterogeneous IgE reactivities to Staphylococcus pseudintermedius strains in dogs with atopic dermatitis, and the identification of DM13-domain-containing protein as a bacterial IgE-reactive molecule
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<i>Staphylococcus pseudintermedius</i> is one of the major pathogens causing canine skin infection. In canine atopic dermatitis (AD), heterogeneous strains of S. pseudintermedius reside on the affected skin site. Because an increase in specific IgE to this bacterium has been reported, S. pseudintermedius is likely to exacerbate the severity of canine AD. In this study, the IgE reactivities to various S. pseudintermedius strains and the IgE-reactive molecules of S. pseudintermedius were investigated. First, examining the IgE reactivities to eight strains of S. pseudintermedius using 141 sera of AD dogs, strain variation of S. pseudintermedius showed 10?63% of the IgE reactivities. This is different from the expected result based on the concept of Staphylococcus aureus clonality in AD patients. Moreover, according to the western blot analysis, there were more than four proteins reactive to IgE. Subsequently, the analysis of the common IgE-reactive protein at ?15?kDa confirmed that the DM13-domain-containing protein was reactive in AD dogs, which is not coincident with any S. aureus IgE-reactive molecules. Considering these, S. pseudintermedius is likely to exacerbate AD severity in dogs, slightly different from the case of S. aureus in human AD.
en-copyright=
kn-copyright=

en-aut-name=Takemura-UchiyamaIyo
en-aut-sei=Takemura-Uchiyama
en-aut-mei=Iyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TsuruiHiroki
en-aut-sei=Tsurui
en-aut-mei=Hiroki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShimakuraHidekatsu
en-aut-sei=Shimakura
en-aut-mei=Hidekatsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NasukawaTadahiro
en-aut-sei=Nasukawa
en-aut-mei=Tadahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ImanishiIchiro
en-aut-sei=Imanishi
en-aut-mei=Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=UchiyamaJumpei
en-aut-sei=Uchiyama
en-aut-mei=Jumpei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=FukuyamaTomoki
en-aut-sei=Fukuyama
en-aut-mei=Tomoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SakamotoShuji
en-aut-sei=Sakamoto
en-aut-mei=Shuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MorisawaKeiko
en-aut-sei=Morisawa
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=FujimuraMasato
en-aut-sei=Fujimura
en-aut-mei=Masato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=MurakamiHironobu
en-aut-sei=Murakami
en-aut-mei=Hironobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KanamaruShuji
en-aut-sei=Kanamaru
en-aut-mei=Shuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KurokawaKenji
en-aut-sei=Kurokawa
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=KawamotoKeiko
en-aut-sei=Kawamoto
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=IyoriKeita
en-aut-sei=Iyori
en-aut-mei=Keita
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=SakaguchiMasahiro
en-aut-sei=Sakaguchi
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

affil-num=1
en-affil=Department of Bacteriology, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=School of Veterinary Medicine, Azabu University, Fuchinobe 1-17-71
kn-affil=

affil-num=3
en-affil=School of Veterinary Medicine, Azabu University
kn-affil=

affil-num=4
en-affil=School of Veterinary Medicine, Azabu University
kn-affil=

affil-num=5
en-affil=School of Veterinary Medicine, Azabu University
kn-affil=

affil-num=6
en-affil=Department of Bacteriology, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama Universty
kn-affil=

affil-num=7
en-affil=School of Veterinary Medicine, Azabu University
kn-affil=

affil-num=8
en-affil=Science Research Center, Kochi Medical School
kn-affil=

affil-num=9
en-affil=Science Research Center, Kochi Medical School
kn-affil=

affil-num=10
en-affil=Fujimura Animal Hospital
kn-affil=

affil-num=11
en-affil=School of Veterinary Medicine, Azabu University
kn-affil=

affil-num=12
en-affil=Department of Life Science and Technology, Tokyo Institute of Technology
kn-affil=

affil-num=13
en-affil=Faculty of Pharmaceutical Sciences, Nagasaki International University
kn-affil=

affil-num=14
en-affil=School of Veterinary Medicine, Azabu University
kn-affil=

affil-num=15
en-affil=Vet Derm Tokyo, Dermatological and Laboratory Service for Animals
kn-affil=

affil-num=16
en-affil=School of Veterinary Medicine, Azabu University
kn-affil=
en-keyword=Staphylococcus pseudintermedius
kn-keyword=Staphylococcus pseudintermedius
en-keyword=atopic dermatitis
kn-keyword=atopic dermatitis
en-keyword= IgE
kn-keyword= IgE
en-keyword=dogs
kn-keyword=dogs
en-keyword=DM13-domain-containing protein
kn-keyword=DM13-domain-containing protein
en-keyword=exacerbation factor
kn-keyword=exacerbation factor
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=
article-no=
start-page=343
end-page=357
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Use of Table-Talk Role-Playing Game (TRPG) to Promote Communication Behaviors among Children with ASD
kn-title=テーブルトーク・ロールプレイングゲーム（TRPG）におけるASD およびADHD 児のコミュニケーション行動の変容
en-subtitle=
kn-subtitle=
en-abstract=This study examined the improvement of communication behaviors among children with ASD using table talk role-playing game (TRPG). Three students with ASD or ADHD participated in this study and played TRPG for seven sessions. The participants were assessed on the changes of communication behaviors in the “Battle” and “Seek” phases (Kato, 2019). We analyzed the communication behaviors by the transcript of TRPG playing sessions. Results of transcript showed that the frequency and variations of communication behaviors improved in both phases. This study suggested that TRPG was effective for ASD students to have experience of successful communication and interaction among peers of the same age.
kn-abstract=本研究では，自閉スペクトラム症(ASD)または注意欠陥多動性障害(ADHD)のある小学生3名を対象に，テーブルトーク・ロールプレイングゲーム(TRPG)を用いた余暇活動を実施し，児童同士のコミュニケーション行動の変容について検討した。加藤ら(2019)による「いただきダンジョンRPG」において，ゲーム上の場面区分「探索フェイズ」「戦闘フェイズ」が，児童同士の発話量と発話内容にどのような変化をもたらすかについて，実際の活動場面からトランスクリプトを作成して分析した。その結果，児童同士の発話量が「探索フェイズ」「戦闘フェイズ」の両方において増加し，発話内容も多様化した。この結果から，TRPG を用いた余暇活動は，同年代の他者とのコミュニケーションや交流機会の成功体験を蓄積できる活動として，ASD 児にとって有用であることが示唆された。
en-copyright=
kn-copyright=

en-aut-name=KinoshitaGo
en-aut-sei=Kinoshita
en-aut-mei=Go
kn-aut-name=木下豪
kn-aut-sei=木下
kn-aut-mei=豪
aut-affil-num=1
ORCID=

en-aut-name=TanjiTakayuki
en-aut-sei=Tanji
en-aut-mei=Takayuki
kn-aut-name=丹治敬之
kn-aut-sei=丹治
kn-aut-mei=敬之
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Master’ s degree program student of Graduate School of Education, Okayama University
kn-affil=岡山大学大学院教育学研究科

affil-num=2
en-affil=Graduate School of Education, Okayama University
kn-affil=岡山大学学術研究院教育学域
en-keyword=ASD(Autism Spectrum Disorder) 
kn-keyword=ASD(Autism Spectrum Disorder) 
en-keyword=TRPG(Table-Talk Role Playing Game)
kn-keyword=TRPG(Table-Talk Role Playing Game)
en-keyword=コミュニケーション(Communication)
kn-keyword=コミュニケーション(Communication)
en-keyword=余暇活動(Leisure Activities)
kn-keyword=余暇活動(Leisure Activities)
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=1
article-no=
start-page=97
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Prevalence of Chronic Kidney Disease and Variation of Its Risk Factors by the Regions in Okayama Prefecture
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objective: The prevention of chronic kidney disease (CKD) progression is an important issue from health and financial perspectives. We conducted a single-year cross-sectional study to clarify the prevalence of CKD and its risk factors along with variations in these factors among five medical regions in Okayama Prefecture, Japan. Methods and Results: Data concerning the renal function and proteinuria as well as other CKD risk factors were obtained from the database of the Japanese National Health Insurance. The proportion of CKD patients at an increased risk of progression to end-stage renal disease (ESRD), classified as orange and red on the CKD heatmap, ranged from 6-9% and did not vary significantly by the regions. However, the causes of the increased severity differed between regions where renal dysfunction was predominant and regions where there were many patients with proteinuria. CKD risk factors, such as diabetes mellitus, hypertension, hyper low-density lipoprotein-cholesterolemia, obesity, smoking and lack of exercise, also differed among these regions, suggesting that different regions need tailored interventions that suit the characteristics of the region, such as an increased health checkup ratio, dietary guidance and promotion of exercise opportunities. Conclusions: Approximately 6-9% of people are at an increased risk of developing ESRD (orange or red on a CKD heatmap) among the population with National Health Insurance in Okayama Prefecture. The underlying health problems that cause CKD may differ among the regions. Thus, it is necessary to consider intervention methods for preventing CKD progression that are tailored to each region's health problems.
en-copyright=
kn-copyright=

en-aut-name=UmebayashiRyoko
en-aut-sei=Umebayashi
en-aut-mei=Ryoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UchidaHaruhito Adam
en-aut-sei=Uchida
en-aut-mei=Haruhito Adam
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Matsuoka-UchiyamaNatsumi
en-aut-sei=Matsuoka-Uchiyama
en-aut-mei=Natsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SugiyamaHitoshi
en-aut-sei=Sugiyama
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=chronic kidney disease
kn-keyword=chronic kidney disease
en-keyword=medical checkup
kn-keyword=medical checkup
en-keyword=risk factor
kn-keyword=risk factor
END

start-ver=1.4
cd-journal=joma
no-vol=111
cd-vols=
no-issue=
article-no=
start-page=15
end-page=20
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Big data in the sex chromosomes of Silene plants and a fungus acting as a plant sex chromosome
kn-title=Silene 属植物が保持する性染色体ビッグデータと性操作する菌
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Silene latifolia (Caryophyllaceae) is a dioecious plant that has long been used for study on sex chromosomes in plants. The advantage but also disadvantage of S. latifolia as a model system is the size of the Y chromosome that contains an extremely large male-specific region (approx. > 500 Mb). This feature implies that the evolutionary history of sex chromo-somes remains in the S. latifolia Y chromosome, while the size makes analyses esoteric. Another advantage is that plants in the genus Silene show variation in reproductive systems; most are gynodioecy (females and hermaphrodites), which is thought of as an evolutionary status before establishment of dioecy (males and females), with a few hermaphrodites and dioecy, suggesting that the genus Silene may represent an epitome of the sex chromosome evolution. Microbotryum is a biotrophic fungi, whose infection causes masculinization of the female flower, as if the fungus acts as the Y chromo-some. Though the underlying molecular mechanisms remain unknown, recent high-throughput sequence technologies provide many candidate genes for sex determination in plants and sex conversion by the fungus. In this article, I review and introduce studies of the Y chromosome in  S. latifolia plant, the evolution of sex chromosomes in the genus Silene, the masculinization of female flowers caused by a fungus infection, and a virus vector that can be used for genetic analysis of the key genes involved in these processes.
en-copyright=
kn-copyright=

en-aut-name=FujitaNaoko
en-aut-sei=Fujita
en-aut-mei=Naoko
kn-aut-name=藤田尚子
kn-aut-sei=藤田
kn-aut-mei=尚子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Course of Applied Plant Science, The Faculty of Agriculture, Okayama University
kn-affil=岡山大学農学部　応用植物科学コース
en-keyword=Silene latifolia
kn-keyword=Silene latifolia
en-keyword=Microbotryum lychnidis-dioicae
kn-keyword=Microbotryum lychnidis-dioicae
en-keyword=anther smut
kn-keyword=anther smut
en-keyword=sex chromosome
kn-keyword=sex chromosome
en-keyword=plant-microbe interaction
kn-keyword=plant-microbe interaction
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=1
article-no=
start-page=76
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220106
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Surveillance of Pathogenicity of Rhizoctonia solani Japanese Isolates with Varied Anastomosis Groups and Subgroups on Arabidopsis thaliana
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Rhizoctonia solani is a necrotrophic plant pathogen with a wide host range. R. solani is a species complex consisting of thirteen anastomosis groups (AGs) defined by compatibility of hyphal fusion reaction and subgroups based on cultural morphology. The relationship between such classifications and host specificity remains elusive. Here, we investigated the pathogenicity of seventeen R. solani isolates (AG-1 to 7) in Japan towards Arabidopsis thaliana using leaf and soil inoculations. The tested AGs, except AG-3 and AG-6, induced symptoms in both methods with variations in pathogenicity. The virulence levels differed even within the same AG and subgroup. Some isolates showed tissue-specific infection behavior. Thus, the AGs and their subgroups are suggested to be not enough to define the virulence (host and tissue specificity) of R. solani. We also evaluated the virulence of the isolates on Arabidopsis plants pretreated with salicylic acid, jasmonic acid, and ethylene. No obvious effects were detected on the symptom formation by the virulence isolates, but ethylene and salicylic acid slightly enhanced the susceptibility to the weak and nonvirulent isolates. R. solani seems to be able to overcome the induced defense by these phytohormones in the infection to Arabidopsis.
en-copyright=
kn-copyright=

en-aut-name=AbdelghanyMai Mohsen Ahmed
en-aut-sei=Abdelghany
en-aut-mei=Mai Mohsen Ahmed
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KurikawaMaria
en-aut-sei=Kurikawa
en-aut-mei=Maria
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WatanabeMegumi
en-aut-sei=Watanabe
en-aut-mei=Megumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MatsuiHidenori
en-aut-sei=Matsui
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamamotoMikihiro
en-aut-sei=Yamamoto
en-aut-mei=Mikihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IchinoseYuki
en-aut-sei=Ichinose
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ToyodaKazuhiro
en-aut-sei=Toyoda
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KouzaiYusuke
en-aut-sei=Kouzai
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NoutoshiYoshiteru
en-aut-sei=Noutoshi
en-aut-mei=Yoshiteru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Agriculture, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=7
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=8
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=9
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=Rhizoctonia solani
kn-keyword=Rhizoctonia solani
en-keyword=anastomosis group
kn-keyword=anastomosis group
en-keyword=phytohormones
kn-keyword=phytohormones
en-keyword=pathogenicity
kn-keyword=pathogenicity
en-keyword=Arabidopsis thaliana
kn-keyword=Arabidopsis thaliana
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=1
article-no=
start-page=21816
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20211108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Genomic characterization between strains selected for death-feigning duration for avoiding attack of a beetle
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Predator avoidance is an important behavior that affects the degree of adaptation of organisms. We compared the DNA variation of one of the predator-avoidance behaviors, the recently extensively studied "death-feigning behavior", between the long strain bred for feigning death for a long time and the short strain bred for feigning death for a short time. To clarify how the difference in DNA sequences between the long and short strains corresponds to the physiological characteristics of the death-feigning duration at the transcriptome level, we performed comprehensive and comparative analyses of gene variants in Tribolium castaneum strains using DNA-resequencing. The duration of death feigning involves many gene pathways, including caffeine metabolism, tyrosine metabolism, tryptophan metabolism, metabolism of xenobiotics by cytochrome P450, longevity regulating pathways, and circadian rhythm. Artificial selection based on the duration of death feigning results in the preservation of variants of genes in these pathways in the long strain. This study suggests that many metabolic pathways and related genes may be involved in the decision-making process of anti-predator animal behavior by forming a network in addition to the tyrosine metabolic system, including dopamine, revealed in previous studies.
en-copyright=
kn-copyright=

en-aut-name=TanakaKeisuke
en-aut-sei=Tanaka
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SasakiKen
en-aut-sei=Sasaki
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MatsumuraKentarou
en-aut-sei=Matsumura
en-aut-mei=Kentarou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YajimaShunsuke
en-aut-sei=Yajima
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MiyatakeTakahisa
en-aut-sei=Miyatake
en-aut-mei=Takahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=NODAI Genome Research Center, Tokyo University of Agriculture
kn-affil=

affil-num=2
en-affil=Graduate School of Agriculture, Tamagawa University
kn-affil=

affil-num=3
en-affil=Graduate School of Agriculture, Kagawa University
kn-affil=

affil-num=4
en-affil=NODAI Genome Research Center, Tokyo University of Agriculture
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=6
article-no=
start-page=745
end-page=750
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Non-Invasive Prenatal Genetic Testing (NIPT) Leading to Prenatal Diagnosis of Trisomy 21 Mosaicism and 18q Deletion Syndrome: Two Cases
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=NIPT is non-definitive testing to estimate the possibility that fetuses have trisomy 21, trisomy 18, or trisomy 13. However, in NIPT-positive and indeterminate cases, rare chromosomal disease may become apparent, requiring advanced genetic considerations and counseling skills. We experienced two such cases, a trisomy 21 mosaicism case triggered by NIPT-positive status and 18q deletion syndrome triggered by NIPT-indeterminate status. These cases have two clinical implications for NIPT. First, it was revealed that trisomy mosaicism might be found in NIPT-positive cases that have lower Z-Scores than those inferred from the fraction of fetal cfDNA in the case of standard trisomy. Second, it is possible that microdeletion syndrome could be the reason for an indeterminate NIPT result. Today’s genetic counseling requires more expertise in ethics and communication as well as genetic science because NIPT can lead to totally unexpected results.
en-copyright=
kn-copyright=

en-aut-name=HayataKei
en-aut-sei=Hayata
en-aut-mei=Kei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MishimaSakurako
en-aut-sei=Mishima
en-aut-mei=Sakurako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OhiraAkiko
en-aut-sei=Ohira
en-aut-mei=Akiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TaniKazumasa
en-aut-sei=Tani
en-aut-mei=Kazumasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MakiJota
en-aut-sei=Maki
en-aut-mei=Jota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=EtoEriko
en-aut-sei=Eto
en-aut-mei=Eriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OgawaChikako
en-aut-sei=Ogawa
en-aut-mei=Chikako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MasuyamaHisashi
en-aut-sei=Masuyama
en-aut-mei=Hisashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=2
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=3
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=4
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=5
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=6
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=7
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=8
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=
en-keyword=NIPT
kn-keyword=NIPT
en-keyword=massively parallel sequencing
kn-keyword=massively parallel sequencing
en-keyword=trisomy 21 mosaicism
kn-keyword=trisomy 21 mosaicism
en-keyword=18q-deletion syndrome
kn-keyword=18q-deletion syndrome
en-keyword=genetic counseling
kn-keyword=genetic counseling
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=
article-no=
start-page=103297
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Germplasm evaluation for crop improvement: Analysis of grain quality and cadmium accumulation in barley
en-subtitle=
kn-subtitle=
en-abstract=Evaluating genetic variation in barley (Hordeum vulgare) germplasm, combined with genome-wide genotyping, is vital for identifying genes controlling important grain-quality traits. For example, in addition...
kn-abstract=Evaluating genetic variation in barley (Hordeum vulgare) germplasm, combined with genome-wide genotyping, is vital for identifying genes controlling important grain-quality traits. For example, in addition to traditional grain quality properties such as starch and protein contents, grain safety parameters such as heavy metal content, are important in the use of barley for human food and animal feed. A number of genes affecting grain quality have been identified by map-based cloning strategies and functionally analyzed by genetic transformation experiments. Moreover, germplasm evaluation yielded information that enabled the introgression of a key gene controlling grain cadmium accumulation into an elite barley cultivar, reducing the content of this heavy metal in grain. Genotyping of molecular markers and resequencing of germplasm accessions may provide information about how grain quality?related loci evolved and how the current allelic diversity was established. In this review, we describe germplasm resources for barley grain quality?related traits and the methods used to analyze the functions of genes controlling these traits, illustrating cadmium accumulation as an example. We also discuss future directions for the efficient identification of grain quality?related genes.
en-copyright=
kn-copyright=

en-aut-name=SatoKazuhiro
en-aut-sei=Sato
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakedaKazuyoshi
en-aut-sei=Takeda
en-aut-mei=Kazuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MaJian Feng
en-aut-sei=Ma
en-aut-mei=Jian Feng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=3
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=Barley
kn-keyword=Barley
en-keyword=Core collection
kn-keyword=Core collection
en-keyword= Genome analysis
kn-keyword= Genome analysis
en-keyword=Genome-wide association study
kn-keyword=Genome-wide association study
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=1
article-no=
start-page=7246
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Trends in the incidence and mortality of legionellosis in Japan: a nationwide observational study, 1999-2017
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study examined temporal trend, seasonality, and geographical variations of legionellosis incidence and mortality in Japan. This nationwide observational study used the Japanese Vital Statistics and Infectious Diseases Weekly Report (1999-2017) data to calculate legionellosis crude and age-adjusted incidence and mortality rates per 100,000 population by age and sex. Incidence was compared among the 4 seasons and regional incidence among 47 prefectures. Of 13,613 (11,194 men) people with legionellosis in Japan, 725 (569 men) were fatal. Increasing incidence trend occurred from 0.0004 (1999) to 1.37 (2017) per 100,000 population. People aged >= 70 years accounted for 43.1% overall; men's age-adjusted incidence rate was consistently approximately five times higher than for women. Significantly higher incidence occurred in summer than in winter (p=0.013). Geographically, highest incidence (>= 2.0 per 100,000 population) occurred in Hokuriku District, with increasing trends in Hokkaido and middle-part of Japan. Estimated fatality rates decreased consistently at 5.9% (95% confidence interval: - 8.1, - 3.5) annually, from 1999 to 2017, with no trend change point. Increasing legionellosis incidence occurred in Japan during 1999-2017, with declining estimated fatality rates. In this aging society and warming world, disease clinical burden may further deteriorate in future due to increasing incidence trends.
en-copyright=
kn-copyright=

en-aut-name=FukushimaShinnosuke
en-aut-sei=Fukushima
en-aut-mei=Shinnosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HagiyaHideharu
en-aut-sei=Hagiya
en-aut-mei=Hideharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OtsukaYuki
en-aut-sei=Otsuka
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KoyamaToshihiro
en-aut-sei=Koyama
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of General Medicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of General Medicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of General Medicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of General Medicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=1
article-no=
start-page=266
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210710
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Genome sequence analysis of new plum pox virus isolates from Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objective To find mutations that may have recently occurred in Plum pox virus (PPV), we collected six PPV-infected plum/peach trees from the western part of Japan and one from the eastern part. After sequencing the full-length PPV genomic RNAs, we compared the amino acid sequences with representative isolates of each PPV strain. Results All new isolates were found to belong to the PPV-D strain: the six isolates collected from western Japan were identified as the West-Japan strain while the one collected from eastern Japan as the East-Japan strain. Amino acid sequence analysis of these seven isolates suggested that the 1407th and 1529th amino acid residues are characteristic of the West-Japan and the East-Japan strains, respectively. Comparing them with the corresponding amino acid residues of the 47 non-Japanese PPV-D isolates revealed that these amino acid residues are undoubtedly unique. A further examination of the relevant amino acid residues of the other 210 PPV-D isolates collected in Japan generated a new hypothesis regarding the invasion route from overseas and the subsequent diffusion route within Japan: a PPV-D strain might have invaded the western part of Japan from overseas and spread throughout Japan.
en-copyright=
kn-copyright=

en-aut-name=MoriTomoaki
en-aut-sei=Mori
en-aut-mei=Tomoaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WarnerChiaki
en-aut-sei=Warner
en-aut-mei=Chiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OhnoSerika
en-aut-sei=Ohno
en-aut-mei=Serika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MoriKoichi
en-aut-sei=Mori
en-aut-mei=Koichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TobimatsuTakamasa
en-aut-sei=Tobimatsu
en-aut-mei=Takamasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SeraTakashi
en-aut-sei=Sera
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry and Biotechnology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Applied Chemistry and Biotechnology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Applied Chemistry and Biotechnology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Applied Chemistry and Biotechnology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Applied Chemistry and Biotechnology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Applied Chemistry and Biotechnology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=Plum pox virus
kn-keyword=Plum pox virus
en-keyword=Complete genome sequence
kn-keyword=Complete genome sequence
en-keyword=Phylogenetic analysis
kn-keyword=Phylogenetic analysis
en-keyword=Sequence alignment analysis
kn-keyword=Sequence alignment analysis
en-keyword=Genetic variation
kn-keyword=Genetic variation
END

start-ver=1.4
cd-journal=joma
no-vol=27
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=17
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=For development of an ESD-based teacher training program on climate change : overlooking geo-phenomena on various timescales
kn-title=気候変動に関するESD教師教育開発へ向けて：様々な時間スケールの地学現象の俯瞰
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Since the recent climate change is an important topic in the context of SDGs (Sustainable Development Goals) and ESD (Education for Sustainable Development), teacher training course should produce educators with sufficient geo-literacy. In order to meet this requirement, the authors have designed a study plan that facilitates students’ better understanding of current climate change issues, which will be offered in a lecture at university by two speakers who have different specialties, paleoenvironmental science and meteorology. Summary of the lecture is as follows. At first, from the branch of paleoenvironmental science, a major cooling
event at the Eocene/Oligocene boundary and the glacial-interglacial cycles in the Quaternary will be explained. We will then instruct the participants to compare these climatic events with recent global warming, in order to remind them of the extraordinary higher speed of the recent climate change than climatic events in the geological past. Followed by these global topics, climatological features in East Asia including Japan (e.g. regional/seasonal difference in climate and year-to-year variations) will be demonstrated in order to relate local issues to global ones. By these efforts, the lecture aims to cultivate students’ ability to grasp geophenomena from various aspects and understand the true nature of problems, which may contribute producing educators who can execute ESD programs.
en-copyright=
kn-copyright=

en-aut-name=KatoYuji
en-aut-sei=Kato
en-aut-mei=Yuji
kn-aut-name=加藤悠爾
kn-aut-sei=加藤
kn-aut-mei=悠爾
aut-affil-num=1
ORCID=

en-aut-name=KatoKuranoshin
en-aut-sei=Kato
en-aut-mei=Kuranoshin
kn-aut-name=加藤内藏進
kn-aut-sei=加藤
kn-aut-mei=内藏進
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Center for Advanced Marine Core Research, Kochi University
kn-affil=高知大学 海洋コア総合研究センター

affil-num=2
en-affil=Graduate School of Education, Okayama University
kn-affil=岡山大学大学院教育学研究科
en-keyword=time scales
kn-keyword=time scales
en-keyword=geologic events
kn-keyword=geologic events
en-keyword=paleoenvironmental science
kn-keyword=paleoenvironmental science
en-keyword=meteorology and climatology
kn-keyword=meteorology and climatology
en-keyword=global warming
kn-keyword=global warming
en-keyword=ESD
kn-keyword=ESD
en-keyword=SDGs
kn-keyword=SDGs
END

start-ver=1.4
cd-journal=joma
no-vol=231
cd-vols=
no-issue=1
article-no=
start-page=75
end-page=84
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210504
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Divergence in red light responses associated with thermal reversion of phytochrome B between high‐ and low‐latitude species
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Summary<br>
・Phytochromes play a central role in mediating adaptive responses to light and temperature throughout plant life cycles. Despite evidence for adaptive importance of natural variation in phytochromes, little information is known about molecular mechanisms that modulate physiological responses of phytochromes in nature.<br>
・We show evolutionary divergence in physiological responses relevant to thermal stability of a physiologically active form of phytochrome (Pfr) between two sister species of Brassicaceae growing at different latitudes.<br>
The higher latitude species (Cardamine bellidifolia; Cb) responded more strongly to light‐limited conditions compared with its lower latitude sister (C. nipponica; Cn). Moreover, CbPHYB conferred stronger responses to both light‐limited and warm conditions in the phyB‐deficient mutant of Arabidopsis thaliana than CnPHYB: that is Pfr CbphyB was more stable in nuclei than CnphyB. <br>
・Our findings suggest that fine tuning Pfr stability is a fundamental mechanism for plants to optimise phytochrome‐related traits in their evolution and adapt to spatially varying environments, and open a new avenue to understand molecular mechanisms that fine tune phytochrome responses in nature.
en-copyright=
kn-copyright=

en-aut-name=IkedaHajime
en-aut-sei=Ikeda
en-aut-mei=Hajime
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SuzukiTomomi
en-aut-sei=Suzuki
en-aut-mei=Tomomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkaYoshito
en-aut-sei=Oka
en-aut-mei=Yoshito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=GustafssonA. Lovisa S.
en-aut-sei=Gustafsson
en-aut-mei=A. Lovisa S.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=BrochmannChristian
en-aut-sei=Brochmann
en-aut-mei=Christian
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MochizukiNobuyoshi
en-aut-sei=Mochizuki
en-aut-mei=Nobuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NagataniAkira
en-aut-sei=Nagatani
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Science, Kyoto University
kn-affil=

affil-num=3
en-affil=Graduate School of Science, Kyoto University
kn-affil=

affil-num=4
en-affil=Natural History Museum, University of Oslo
kn-affil=

affil-num=5
en-affil=Natural History Museum, University of Oslo
kn-affil=

affil-num=6
en-affil=Graduate School of Science, Kyoto University
kn-affil=

affil-num=7
en-affil=Graduate School of Science, Kyoto University
kn-affil=
en-keyword=alpine plants
kn-keyword=alpine plants
en-keyword=Brassicaceae
kn-keyword=Brassicaceae
en-keyword=Cardamine
kn-keyword=Cardamine
en-keyword=phytochrome
kn-keyword=phytochrome
en-keyword=thermal reversion
kn-keyword=thermal reversion
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=2
article-no=
start-page=249
end-page=253
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Endogenous Bacterial Endophthalmitis Caused by Iliopsoas Abscess
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 79-year-old woman presented to our hospital with a 10-day history of gradually worsening binocular vision and severe backache. Further investigations revealed poor bilateral best-corrected visual acuities (BCVA), bilateral vitreous opacities, gray-white lesions scattered throughout the retina, and a left iliopsoas abscess on CT that later grew out methicillin-sensitive S. aureus. The abscess was drained and intravenous antibiotics were initiated, but the left eye additionally required intravitreal vancomycin. BCVA for both eyes normalized within 1 year. Intramuscular abscess should be considered as a possible primary lesion in cases of endogenous bacterial endophthalmitis.
en-copyright=
kn-copyright=

en-aut-name=SunWeiying
en-aut-sei=Sun
en-aut-mei=Weiying
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShiodeYusuke
en-aut-sei=Shiode
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TokumasuKazuki
en-aut-sei=Tokumasu
en-aut-mei=Kazuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KimuraShuhei
en-aut-sei=Kimura
en-aut-mei=Shuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HosokawaMio
en-aut-sei=Hosokawa
en-aut-mei=Mio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=DoiShinichiro
en-aut-sei=Doi
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakahashiKosuke
en-aut-sei=Takahashi
en-aut-mei=Kosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MatobaRyo
en-aut-sei=Matoba
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MorizaneYuki
en-aut-sei=Morizane
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=endogenous bacterial endophthalmitis
kn-keyword=endogenous bacterial endophthalmitis
en-keyword=methicillin-sensitive Staphylococcus aureus
kn-keyword=methicillin-sensitive Staphylococcus aureus
en-keyword=iliopsoas abscess
kn-keyword=iliopsoas abscess
en-keyword=intravitreal injection
kn-keyword=intravitreal injection
en-keyword=vancomycin
kn-keyword=vancomycin
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=2
article-no=
start-page=139
end-page=145
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evaluation of the Imaging Process for a Novel Subtraction Method Using Apparent Diffusion Coefficient Values
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Diffusion-weighted imaging may be used to obtain the apparent diffusion coefficient (ADC), which aids the diagnosis of cerebral infarction and tumors. An ADC reflects elements of free diffusion. Diffusion kurtosis imaging (DKI) has attracted attention as a restricted diffusion imaging technique. The ADC subtraction method (ASM) was developed to visualize restricted diffusion with high resolution by using two ADC maps taken with different diffusion times. We conducted the present study to provide a bridge between the reported basic ASM research and clinical research. We developed new imaging software for clinical use and evaluated its performance herein. This software performs the imaging process automatically and continuously at the pixel level, using ImageJ software. The new software uses a macro or a plugin which is compatible with various operating systems via a Java Virtual Machine. We tested the new imaging software’s performance by using a Jurkat cell bio-phantom, and the statistical evaluation of the performance clarified that the ASM values of 99.98% of the pixels in the bio-phantom and physiological saline were calculated accurately (p<0.001). The new software may serve as a useful tool for future clinical applications and restricted diffusion imaging research.
en-copyright=
kn-copyright=

en-aut-name=HamadaKentaro
en-aut-sei=Hamada
en-aut-mei=Kentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KurodaMasahiro
en-aut-sei=Kuroda
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YoshimuraYuuki 
en-aut-sei=Yoshimura
en-aut-mei=Yuuki 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KhasawnehAbdullah
en-aut-sei=Khasawneh
en-aut-mei=Abdullah
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=BarhamMajd
en-aut-sei=Barham
en-aut-mei=Majd
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TekikiNouha
en-aut-sei=Tekiki
en-aut-mei=Nouha
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SugiantoIrfan
en-aut-sei=Sugianto
en-aut-mei=Irfan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=BamgboseBabatunde O.
en-aut-sei=Bamgbose
en-aut-mei=Babatunde O.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KonishiKohei
en-aut-sei=Konishi
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=SugimotoKohei
en-aut-sei=Sugimoto
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=IshizakaHinata
en-aut-sei=Ishizaka
en-aut-mei=Hinata
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KurozumiAkira
en-aut-sei=Kurozumi
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=MatsushitaToshi 
en-aut-sei=Matsushita
en-aut-mei=Toshi 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=OhnoSeiichiro
en-aut-sei=Ohno
en-aut-mei=Seiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=KanazawaSusumu
en-aut-sei=Kanazawa
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=AsaumiJunichi
en-aut-sei=Asaumi
en-aut-mei=Junichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

affil-num=1
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Radiology, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Oral and Maxillofacial Radiology, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Radiology, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Oral and Maxillofacial Radiology, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Radiology, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=11
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=12
en-affil=Central Division of Radiology, Okayama University Hospital
kn-affil=

affil-num=13
en-affil=Central Division of Radiology, Okayama University Hospital
kn-affil=

affil-num=14
en-affil=Central Division of Radiology, Okayama University Hospital
kn-affil=

affil-num=15
en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=16
en-affil=Department of Oral and Maxillofacial Radiology, Okayama University Hospital
kn-affil=
en-keyword=apparent diffusion coefficient
kn-keyword=apparent diffusion coefficient
en-keyword=ADC subtraction method
kn-keyword=ADC subtraction method
en-keyword=restricted diffusion
kn-keyword=restricted diffusion
en-keyword=ImageJ
kn-keyword=ImageJ
en-keyword=plugin
kn-keyword=plugin
END

start-ver=1.4
cd-journal=joma
no-vol=2021
cd-vols=
no-issue=
article-no=
start-page=6617370
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210226
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Case of Myoepithelial Hamartoma: Morphological Variation Supported by OCT4 Expression
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this report, we describe a patient with myoepithelial hamartoma, which is regarded as synonymous with adenomyosis and heterotopic pancreas. Endoscopy revealed a submucosal tumor in the antrum of the stomach. Subsequently, distal gastrectomy with Roux-en-Y reconstruction was performed. Histological findings of adenomyomatous lesion and heterotopic pancreatic tissue were observed in this lesion. The distribution of OCT4, which is a pluripotency marker, varied in each part.
en-copyright=
kn-copyright=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NishidaKenji
en-aut-sei=Nishida
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IwamuroMasaya
en-aut-sei=Iwamuro
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KikuchiSatoru
en-aut-sei=Kikuchi
en-aut-mei=Satoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YoshinoTadashi
en-aut-sei=Yoshino
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Pathology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterological Surgery, Okayama University, Graduate School of Medicine, Dentistry, and Pharmaceutical Science
kn-affil=

affil-num=5
en-affil=Department of Pathology, Okayama University, Graduate School of Medicine, Dentistry, and Pharmaceutical Science
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=3
article-no=
start-page=55
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210309
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Core-Shell Droplet Generation Device Using a Flexural Bolt-Clamped Langevin-Type Ultrasonic Transducer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Droplets with a core-shell structure formed from two immiscible liquids are used in various industrial field owing to their useful physical and chemical characteristics. Efficient generation of uniform core-shell droplets plays an important role in terms of productivity. In this study, monodisperse core-shell droplets were efficiently generated using a flexural bolt-clamped Langevin-type transducer and two micropore plates. Water and silicone oil were used as core and shell phases, respectively, to form core-shell droplets in air. When the applied pressure of the core phase, the applied pressure of the shell phase, and the vibration velocity in the micropore were 200 kPa, 150 kPa, and 8.2 mm/s, respectively, the average diameter and coefficient of variation of the droplets were 207.7 mu m and 1.6%, respectively. A production rate of 29,000 core-shell droplets per second was achieved. This result shows that the developed device is effective for generating monodisperse core-shell droplets.
en-copyright=
kn-copyright=

en-aut-name=OmoriKentaro
en-aut-sei=Omori
en-aut-mei=Kentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FujimotoNozomu
en-aut-sei=Fujimoto
en-aut-mei=Nozomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KandaTakefumi
en-aut-sei=Kanda
en-aut-mei=Takefumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=WakimotoShuichi
en-aut-sei=Wakimoto
en-aut-mei=Shuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SenoNorihisa
en-aut-sei=Seno
en-aut-mei=Norihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=core-shell droplet
kn-keyword=core-shell droplet
en-keyword=microfluidic device
kn-keyword=microfluidic device
en-keyword=ultrasonic transducer
kn-keyword=ultrasonic transducer
END

start-ver=1.4
cd-journal=joma
no-vol=311
cd-vols=
no-issue=
article-no=
start-page=106640
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Thermocapillary effects in two-phase medium and applications to metal-silicate separation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The separation of a liquid phase from a solid but deformable matrix made of mineral grains is controlled at small scale by surface tension. The role of interfacial surface tension is twofold as it explains how a small volume of liquid phase can infiltrate the grain boundaries, be distributed and absorbed in the matrix, but after complete wetting of the grains, surface tension favors the self-separation of the liquid and solid phases. Another consequence of surface tension is the existence of Marangoni forces, which are related to the gradients of surface tension that are are usually due to temperature variations. In this paper, using a continuous multi-phase formalism we clarify the role of these different effects and quantify their importances at the scale of laboratory experiments and in planets. We show that Marangoni forces can control the liquid metal-solid silicate phase separation in laboratory experiments. The Marangoni force might help to maintain the presence of metal at the surface of asteroids and planetesimals that have undergone significant melting.
en-copyright=
kn-copyright=

en-aut-name=RicardYanick
en-aut-sei=Ricard
en-aut-mei=Yanick
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=LabrosseSt?phane
en-aut-sei=Labrosse
en-aut-mei=St?phane
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TerasakiHidenori
en-aut-sei=Terasaki
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=BercoviciDavid
en-aut-sei=Bercovici
en-aut-mei=David
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Universit? de Lyon, ENSL, UCBL, Laboratoire LGLTPE
kn-affil=

affil-num=2
en-affil=Universit? de Lyon, ENSL, UCBL, Laboratoire LGLTPE
kn-affil=

affil-num=3
en-affil=Okayama University, Department of Earth Sciences
kn-affil=

affil-num=4
en-affil=Yale University, Department of Earth & Planetary Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=
article-no=
start-page=100044
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20211231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Structural basis of enzyme activity regulation by the propeptide of l-lysine α-oxidase precursor from Trichoderma viride
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Harmuful proteins are usually synthesized as inactive precursors and are activated by proteolytic processing. l-Amino acid oxidase (LAAO) is a flavoenzyme that catalyzes the oxidative deamination of l-amino acid to produce a 2-oxo acid with ammonia and highly toxic hydrogen peroxide and, therefore, is expressed as a precursor. The LAAO precursor shows significant variation in size and the cleavage pattern for activation. However, the molecular mechanism of how the propeptide suppresses the enzyme activity remains unclear except for deaminating/decarboxylating Pseudomonasl-phenylalanine oxidase (PAO), which has a short N-terminal propeptide composed of 14 residues. Here we show the inactivation mechanism of the l-lysine oxidase (LysOX) precursor (prLysOX), which has a long N-terminal propeptide composed of 77 residues, based on the crystal structure at 1.97?? resolution. The propeptide of prLysOX indirectly changes the active site structure to inhibit the enzyme activity. prLysOX retains weak enzymatic activity with strict specificity for l-lysine and shows raised activity in acidic conditions. The structures of prLysOX crystals that soaked in a solution with various concentrations of l-lysine have revealed that prLysOX can adopt two conformations; one is the inhibitory form, and the other is very similar to mature LysOX. The propeptide region of the latter form is disordered, and l-lysine is bound to the latter form. These results indicate that prLysOX uses a different strategy from PAO to suppress the enzyme activity and suggest that prLysOX can be activated quickly in response to the environmental change without proteolytic processing.
en-copyright=
kn-copyright=

en-aut-name=KitagawaMasaki
en-aut-sei=Kitagawa
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ItoNanako
en-aut-sei=Ito
en-aut-mei=Nanako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MatsumotoYuya
en-aut-sei=Matsumoto
en-aut-mei=Yuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SaitoMasaya
en-aut-sei=Saito
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TamuraTakashi
en-aut-sei=Tamura
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KusakabeHitoshi
en-aut-sei=Kusakabe
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=InagakiKenji
en-aut-sei=Inagaki
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ImadaKatsumi
en-aut-sei=Imada
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Macromolecular Science, Graduate School of Science, Osaka University
kn-affil=

affil-num=2
en-affil=Department of Macromolecular Science, Graduate School of Science, Osaka University
kn-affil=

affil-num=3
en-affil=Department of Biofunctional Chemistry, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Biofunctional Chemistry, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Biofunctional Chemistry, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Enzyme Sensor Co., Ltd.
kn-affil=

affil-num=7
en-affil=Department of Biofunctional Chemistry, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Macromolecular Science, Graduate School of Science, Osaka University
kn-affil=
en-keyword=L-Lysine α-oxidase
kn-keyword=L-Lysine α-oxidase
en-keyword=Crystal structure
kn-keyword=Crystal structure
en-keyword=Precursor
kn-keyword=Precursor
en-keyword=Substrate recognition
kn-keyword=Substrate recognition
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=4
article-no=
start-page=143
end-page=149
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=2020
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Estimation of long-term external nutrient loading from watersheds to Lake Biwa by a combined rainfall-runoff model and loading-discharge curve approach
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=External nutrient loadings to Lake Biwa were estimated using a combined tank model and loading-discharge curve approach. The model was applied to collective drainage basins of the lake’s Imazu (northwest), Hikone (northeast), and Otsu (south) areas. The hourly model was conducted using particular discharges from Kita (Ado) river, Takatoki (Ane) river, and Yasu River to obtain loading curves for phosphate (PO4) and silica (SiO2) by assimilating measured concentrations (2002?2003). The tank model was updated by adding an evapotranspiration routine and direct paths of groundwater discharges to the lake floor. The daily model was calibrated through analysis of water budget among the basin, inflow, lake and outflow, and then validated. The model was established and combined into a loading-discharge curve to determine the long-term external nutrient loadings entering the lake (1980?2017). Seasonal variation in nutrient loadings increased during spring and summer and decreased during winter. Annual phosphate-phosphorus (PO4-P) loading ranged from 217 to 296 tons yr?1 in the North Basin and 45 to 76 tons yr?1 in the South Basin, while SiO2 loading fluctuated from 16,027 to 32,655 tons yr?1 and 2,518 to 5,490 tons yr?1 in the North and South Basins, respectively.
en-copyright=
kn-copyright=

en-aut-name=Le TienHuu
en-aut-sei=Le Tien
en-aut-mei=Huu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkuboKenji
en-aut-sei=Okubo
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Ho ThiPhuong
en-aut-sei=Ho Thi
en-aut-mei=Phuong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SaitoMitsuyo
en-aut-sei=Saito
en-aut-mei=Mitsuyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=School of Chemical, Biological and Environmental Technologies, Vinh University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=1
article-no=
start-page=71
end-page=77
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202102
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Thickness of the Medial Wall of the Acetabulum Prevents Acetabular Fracture during the Insertion of a Cementless Cup in Total Hip Arthroplasty: A Biomechanical Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Intra-operative acetabular fracture is a total hip arthroplasty complication that can occur during cementless cup insertion, especially in osteoporotic patients. We conducted this biomechanical study to investigate the impact resistance of the acetabulum with simulated bones of different density by drop-weight impact testing. Low- and high-density polyurethane foam blocks were used as osteoporotic and healthy bone models, respectively. Polyurethane blocks were used as the acetabular cancellous bone. Composite sheets were used as the acetabu-lum’s medial cortex. The testing revealed that the osteoporotic bone model’s impact resistance was significantly lower than that the healthy bone model’. In the healthy bone model, even thin acetabular cancellous bone with ? 1 mm acetabulum medial cortex was less likely to fracture. In the osteoporotic bone model, fracture was pos-sible without ? 1 mm medial cortex of the acetabulum and thick acetabular cancellous bone. Although impac-tion resistance differs due to bone quality, the impaction resistance in this osteoporotic bone model was equiv-alent to that healthy bone model’s when a thick medial wall was present. To avoid intra-operative acetabulum fracture, surgeons should consider both the bone quality and the thicknesses of the medial cortex and acetabu-lar cancellous bone.
en-copyright=
kn-copyright=

en-aut-name=SankiTomoaki
en-aut-sei=Sanki
en-aut-mei=Tomoaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TetsunagaTomonori
en-aut-sei=Tetsunaga
en-aut-mei=Tomonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FurumatsuTakayuki
en-aut-sei=Furumatsu
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YamadaKazuki
en-aut-sei=Yamada
en-aut-mei=Kazuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KawamuraYoshi
en-aut-sei=Kawamura
en-aut-mei=Yoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=intra-operative acetabular fracture
kn-keyword=intra-operative acetabular fracture
en-keyword=drop weight impact testing
kn-keyword=drop weight impact testing
en-keyword=total hip arthroplasty
kn-keyword=total hip arthroplasty
en-keyword=impact resistance
kn-keyword=impact resistance
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=2
article-no=
start-page=838
end-page=846
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Adsorption enhancement of nitrogen gas by atomically heterogeneous nanospace of boron nitride
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this study, porous boron nitride (p-BN) with hexagonal phase boron nitride (h-BN) pore walls was synthesized using high-temperature calcination. Negligible variation in pore-wall structure can be observed in powder X-ray diffraction (XRD) profiles and infrared (IR) spectra. However, a highly stable p-BN with a stable pore structure even at 973 K under the oxidative conditions is obtained when synthesized at higher than 1573 K under nitrogen gas flow. For p-BN, this stability is obtained by generating h-BN microcrystals. Nitrogen adsorption?desorption isotherms at 77 K provide type-IV features and typical adsorption?desorption hysteresis, which suggests micropore and mesopore formation. Moreover, adsorption?desorption isotherms of Ar at 87 K are measured and compared with those of nitrogen. The relative adsorbed amount of nitrogen (i.e., the amount of nitrogen normalized by that of Ar at each relative pressure or adsorption potential value) on p-BN is considerably larger than that on microporous carbon at low-pressure regions, which suggests the existence of strong adsorption sites on the p-BN surface. In fact, the relative number of adsorbed nitrogen molecules to that of Ar on p-BN is, at most, 150%?200% larger than that on microporous carbon for the same adsorption potential state. Furthermore, additional adsorption enhancement to nitrogen between P/P0 = 10?5 and 10?3 can be observed for p-BN treated at 1673 K, which suggests the uniformly adsorbed layer formation of nitrogen molecules in the vicinity of a basal planar surface. Thus, unlike typical nanoporous sp2 carbons, p-BN materials have the potential to enhance adsorption for certain gas species because of their unique surface state.
en-copyright=
kn-copyright=

en-aut-name=KimuraJun
en-aut-sei=Kimura
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhkuboTakahiro
en-aut-sei=Ohkubo
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name= NishinaYuta
en-aut-sei= Nishina
en-aut-mei=Yuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UritaKoki
en-aut-sei=Urita
en-aut-mei=Koki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KurodaYasushige
en-aut-sei=Kuroda
en-aut-mei=Yasushige
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Research Core for Interdisciplinary Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Engineering, Nagasaki University
kn-affil=

affil-num=5
en-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=11
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200617
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Outcomes of Patients with Pulmonary Atresia with Intact Ventricular Septum Reaching Adulthood
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: There is limited information on outcomes of adult patients with pulmonary atresia with intact ventricular septum (PA-IVS) due to the low incidence of disease and the large variation of surgical histories. Methods: Among 58 patients with repaired PA-IVS, a total of 32 patients aged ?16 years and who were followed at our institution between January 2003 and December 2018 were reviewed. Surgical history, clinical outcomes, and laboratory, echocardiographic and electrocardiographic data were obtained by chart review. Results: Follow-up was from the age of 16 years and the median age at the latest follow-up was 23.7 years. Twenty-four patients had undergone biventricular repair (BVR), 3 had undergone one-and-a half ventricular repair (1.5VR), and 5 had undergone univentricular repair. Over a median follow-up period of 7.7 years (interquartile range: 4.1?11.0 years), 1 BVR patient died suddenly and 7 patients had heart failure. Arrhythmias were present in 5 patients. Ten patients underwent surgical re-interventions, including 4 BVR take-downs with conversion to 1.5VR and 3 Fontan conversions. Overall survival, heart failure-free, arrhythmia-free, and surgical re-intervention-free rates at 5 years and 10 years from the age of 16 years were 96.2% (95% confidence interval [CI], 77.2?99.4) and 96.2% (95% CI, 77.2? 99.4), 81.4% (95% CI, 62.1?92.1) and 74.6% (95%CI, 52.3?88.7), 88.7% (95% CI, 70.1?96.3) and 75.9% (95% CI, 51.7?90.2), and 80.7% (95% CI, 60.8?91.8) and 70.8% (95% CI, 49.7?85.7), respectively. Conclusion: Adults with PA-IVS have preserved long-term survival regardless of the early operative strategy, while they are at risk for heart failure, arrhythmia, and surgical re-intervention. Thus, detailed and continued follow-up is mandatory for all PA-IVS patients from childhood to adulthood. 
en-copyright=
kn-copyright=

en-aut-name=TohNorihisa
en-aut-sei=Toh
en-aut-mei=Norihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KotaniYasuhiro
en-aut-sei=Kotani
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AkagiTeiji
en-aut-sei=Akagi
en-aut-mei=Teiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KurokoYosuke
en-aut-sei=Kuroko
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=BabaKenji
en-aut-sei=Baba
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OtsukiShin-ichi
en-aut-sei=Otsuki
en-aut-mei=Shin-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KasaharaShingo
en-aut-sei=Kasahara
en-aut-mei=Shingo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ItoHiroshi
en-aut-sei=Ito
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Pediatric Cardiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Pediatric Cardiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Pulmonary atresia with intact ventricular septum
kn-keyword=Pulmonary atresia with intact ventricular septum
en-keyword=adult congenital heart disease
kn-keyword=adult congenital heart disease
en-keyword=outcome 
kn-keyword=outcome 
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=1
article-no=
start-page=397
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Multi-Period Maximal Covering Location Problem with Capacitated Facilities and Modules for Natural Disaster Relief Services
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The paper aims to study a multi-period maximal covering location problem with the configuration of different types of facilities, as an extension of the classical maximal covering location problem (MCLP). The proposed model can have applications such as locating disaster relief facilities, hospitals, and chain supermarkets. The facilities are supposed to be comprised of various units, called the modules. The modules have different sizes and can transfer between facilities during the planning horizon according to demand variation. Both the facilities and modules are capacitated as a real-life fact. To solve the problem, two upper bounds-(LR1) and (LR2)-and Lagrangian decomposition (LD) are developed. Two lower bounds are computed from feasible solutions obtained from (LR1), (LR2), and (LD) and a novel heuristic algorithm. The results demonstrate that the LD method combined with the lower bound obtained from the developed heuristic method (LD-HLB) shows better performance and is preferred to solve both small- and large-scale problems in terms of bound tightness and efficiency especially for solving large-scale problems. The upper bounds and lower bounds generated by the solution procedures can be used as the profit approximation by the managerial executives in their decision-making process.
en-copyright=
kn-copyright=

en-aut-name=AlizadehRoghayyeh
en-aut-sei=Alizadeh
en-aut-mei=Roghayyeh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NishiTatsushi
en-aut-sei=Nishi
en-aut-mei=Tatsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=BagherinejadJafar
en-aut-sei=Bagherinejad
en-aut-mei=Jafar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=BashiriMahdi
en-aut-sei=Bashiri
en-aut-mei=Mahdi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Division of Mathematical Science for Social Systems, Department of Systems Innovation, Graduate School of Engineering Science, Osaka University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Sciences, Department of Industrial Innovation Engineering, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Industrial Engineering, Faculty of Engineering, Alzahra University
kn-affil=

affil-num=4
en-affil=School of Strategy and Leadership, Faculty of Business and Law, Coventry University
kn-affil=
en-keyword=maximal covering location problem
kn-keyword=maximal covering location problem
en-keyword=capacitated facility
kn-keyword=capacitated facility
en-keyword=modularity
kn-keyword=modularity
en-keyword=multi-period
kn-keyword=multi-period
en-keyword=Lagrangian decomposition heuristic
kn-keyword=Lagrangian decomposition heuristic
END

start-ver=1.4
cd-journal=joma
no-vol=33
cd-vols=
no-issue=11
article-no=
start-page=1858
end-page=1865
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191224
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An investigation of seasonal variations in the microbiota of milk, feces, bedding, and airborne dust
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objective</br>
The microbiota of dairy cow milk varies with the season, and this accounts in part for the seasonal variation in mastitis-causing bacteria and milk spoilage. The microbiota of the cowshed may be the most important factor because the teats of a dairy cow contact bedding material when the cow is resting. The objectives of the present study were to determine whether the microbiota of the milk and the cowshed vary between seasons, and to elucidate the relationship between the microbiota.</br>
Methods</br>
We used 16S rRNA gene amplicon sequencing to investigate the microbiota of milk, feces, bedding, and airborne dust collected at a dairy farm during summer and winter.</br>
Results</br>
The seasonal differences in the milk yield and milk composition were marginal. The fecal microbiota was stable across the two seasons. Many bacterial taxa of the bedding and airborne dust microbiota exhibited distinctive seasonal variation. In the milk microbiota, the abundances of Staphylococcaceae, Bacillaceae, Streptococcaceae, Microbacteriaceae, and Micrococcaceae were affected by the seasons; however, only Micrococcaceae had the same seasonal variation pattern as the bedding and airborne dust microbiota. Nevertheless, canonical analysis of principle coordinates revealed a distinctive group comprising the milk, bedding, and airborne dust microbiota.</br>
Conclusion</br>
Although the milk microbiota is related to the bedding and airborne dust microbiota, the relationship may not account for the seasonal variation in the milk microbiota. Some major bacterial families stably found in the bedding and airborne dust microbiota, e.g., Staphylococcaceae, Moraxellaceae, Ruminococcaceae, and Bacteroidaceae, may have greater influences than those that varied between seasons.
en-copyright=
kn-copyright=

en-aut-name=NguyenThuong Thi
en-aut-sei=Nguyen
en-aut-mei=Thuong Thi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WuHaoming
en-aut-sei=Wu
en-aut-mei=Haoming
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NishinoNaoki
en-aut-sei=Nishino
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=Cowshed
kn-keyword=Cowshed
en-keyword=Dairy Cow
kn-keyword=Dairy Cow
en-keyword=Microbiota
kn-keyword=Microbiota
en-keyword=Milk
kn-keyword=Milk
en-keyword=Season
kn-keyword=Season
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=6
article-no=
start-page=545
end-page=550
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202012
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Delayed Methotrexate Elimination after Administration of a Medium Dose of Methotrexate in a Patient with Genetic Variants Associated  with Methotrexate Clearance
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Polymorphisms in methotrexate transporter pathways have been associated with methotrexate toxicities and clearance. Recent genome-wide association studies have revealed that the SLCO1B1 T521C variant is associated with methotrexate elimination. We present a case of a pediatric patient with acute lymphoblastic leukemia who suffered from persistently high plasma methotrexate concentrations and acute kidney injuries after the admin-istration of a medium dose of methotrexate. Subsequent genetic analysis showed that he was a carrier of dys-functional genetic variants associated with methotrexate clearance. This case highlights that polymorphisms of methotrexate transporter pathways can adversely affect methotrexate elimination in a clinically significant manner.
en-copyright=
kn-copyright=

en-aut-name=TatebeYasuhisa
en-aut-sei=Tatebe
en-aut-mei=Yasuhisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KanamitsuKiichiro
en-aut-sei=Kanamitsu
en-aut-mei=Kiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KanzakiHirotaka
en-aut-sei=Kanzaki
en-aut-mei=Hirotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IshidaHisashi
en-aut-sei=Ishida
en-aut-mei=Hisashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujiwaraKaori
en-aut-sei=Fujiwara
en-aut-mei=Kaori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=WashioKana
en-aut-sei=Washio
en-aut-mei=Kana
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KitamuraYoshihisa
en-aut-sei=Kitamura
en-aut-mei=Yoshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=ShimadaAkira
en-aut-sei=Shimada
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TsukaharaHirokazu
en-aut-sei=Tsukahara
en-aut-mei=Hirokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of pediatrics, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of pediatrics, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of pediatrics, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of pediatrics, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of pediatrics, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of pediatrics, Okayama University Hospital
kn-affil=
en-keyword=methotrexate
kn-keyword=methotrexate
en-keyword=polymorphism
kn-keyword=polymorphism
en-keyword=drug elimination
kn-keyword=drug elimination
en-keyword=acute kidney injury
kn-keyword=acute kidney injury
en-keyword=acute lymphoblastic leukemia
kn-keyword=acute lymphoblastic leukemia
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=6
article-no=
start-page=537
end-page=544
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202012
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Four Cases with Rare Complications of Intramedullary Screw Fixation for Jones Fracture
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Active treatment with intramedullary screw fixation is now common for athletes with Jones fracture. Outcomes are generally good, but complications can occur. We report 4 rare complications of intramedullary screw fixa-tion. Two cases developed osteomyelitis and pseudarthrosis caused by thermal necrosis. In the other two cases, screw-related complications occurred during the insertion of the tapered headless screw. Although thermal necrosis and screw insertion failures are considered rare complications and not widely reported in the litera-ture, they do occur occasionally. Knowing the mechanisms underlying these complications could help prevent them, and knowing their course could lead caregivers to appropriate interventions when they do occur.
en-copyright=
kn-copyright=

en-aut-name=MorimotoYusuke
en-aut-sei=Morimoto
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KomatsuTaichi
en-aut-sei=Komatsu
en-aut-mei=Taichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TokuhashiYasuaki
en-aut-sei=Tokuhashi
en-aut-mei=Yasuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Nihon University School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Nihon University School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Nihon University School of Medicine
kn-affil=
en-keyword=Jones fracture
kn-keyword=Jones fracture
en-keyword=thermal necrosis
kn-keyword=thermal necrosis
en-keyword=tapered headless screw
kn-keyword=tapered headless screw
END

start-ver=1.4
cd-journal=joma
no-vol=21
cd-vols=
no-issue=
article-no=
start-page=100284
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202012
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A case of type 1 facioscapulohumeral muscular dystrophy (FSHD) with restrictive ventilatory defect and congestive heart failure
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=[Background] Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant muscle disease characterized by asymmetric involvement of muscles in the face, upper extremity, trunk, and lower extremity regions, with variable severity. It was recently reported that restrictive respiratory involvement is more frequent and severe than previously recognized, while cardiac dysfunction other than arrhythmia is still considered extremely rare in FSHD. [Case report] A 59-year-old man presenting with marked muscle atrophy in the trunk and asymmetrical muscle atrophy in the legs was hospitalized because of dyspnea and edema in the face and limbs. Shortness of breath with body movement started from approximately 40?years of age. Muscle biopsy revealed myopathic change with mild to moderate variation in fiber size. The diagnosis of FSHD was made by D4Z4 contraction to three repeats on genetic testing. A pulmonary function test revealed a decline of forced vital capacity (FVC) and a preserved FEV1/FVC indicating restrictive ventilatory defect (RVD). Ultrasonic echocardiogram (UCG) showed diffuse left ventricular hypokinesis, ventricular septum thickening, pericardial effusion, and decreased ejection fraction (LVEF 30%). [Conclusion] Although restrictive ventilatory defect and congestive heart failure are uncommon in FSHD, respiratory and cardiac evaluation may be necessary in patients with FSHD.
en-copyright=
kn-copyright=

en-aut-name=MorimotoNobutoshi
en-aut-sei=Morimoto
en-aut-mei=Nobutoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MorimotoMizuki
en-aut-sei=Morimoto
en-aut-mei=Mizuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakahashiYoshiaki
en-aut-sei=Takahashi
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakamiyaMotonori
en-aut-sei=Takamiya
en-aut-mei=Motonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NishinoIchizo
en-aut-sei=Nishino
en-aut-mei=Ichizo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=AbeKoji
en-aut-sei=Abe
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Neurology, Kagawa Central Prefectural Hospital
kn-affil=

affil-num=2
en-affil=Department of Neurology, Kagawa Central Prefectural Hospital
kn-affil=

affil-num=3
en-affil=Department of Neurology, Kagawa Central Prefectural Hospital
kn-affil=

affil-num=4
en-affil=Department of Neurology, Kagawa Central Prefectural Hospital
kn-affil=

affil-num=5
en-affil=Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP)
kn-affil=

affil-num=6
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Facioscapulohumeral muscular dystrophy (FSHD)
kn-keyword=Facioscapulohumeral muscular dystrophy (FSHD)
en-keyword=Restrictive ventilatory defect (RVD)
kn-keyword=Restrictive ventilatory defect (RVD)
en-keyword=Congestive heart failure (CHF)
kn-keyword=Congestive heart failure (CHF)
END

start-ver=1.4
cd-journal=joma
no-vol=132
cd-vols=
no-issue=2
article-no=
start-page=60
end-page=67
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200803
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Hepatitis C virus (HCV)：Diversity and variation of RNA genome
kn-title=C型肝炎ウイルス（HCV）：RNAゲノムの多様性と変異性
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KatoNobuyuki
en-aut-sei=Kato
en-aut-mei=Nobuyuki
kn-aut-name=加藤宣之
kn-aut-sei=加藤
kn-aut-mei=宣之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍ウイルス学 
en-keyword=HCV ゲノム
kn-keyword=HCV ゲノム
en-keyword=レプリコン複製細胞
kn-keyword=レプリコン複製細胞
en-keyword=長期継代培養
kn-keyword=長期継代培養
en-keyword=遺伝子解析
kn-keyword=遺伝子解析
en-keyword=準種
kn-keyword=準種
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=5
article-no=
start-page=415
end-page=422
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202010
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Oblique Surface Dose Calculation in High-Energy X-ray Therapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=During radiation therapy, incident radiation oblique to the skin surface is high and may cause severe skin damage. Understanding the dose of radiation absorbed by the skin is important for predicting skin damage due to radiation. In this study, we used a high-energy (4 MV) X-ray system and an optically stimulated luminescence dosimeter (OSLD) that was developed for personal exposure dosimetry. We determined the dose variation and angular dependence, which are the characteristics of a small OSLD required to derive the calculation formula for the oblique surface dose. The dose variation was determined using the coefficient of variation. The maximum coefficient of variation for 66 small-field OSLDs was 1.71%. The angular dependence, obtained from the dose ratio of the dosimeter in the vertical direction, had a maximum value of 1.37. We derived a new equation in which the oblique surface dose can be calculated within the error range of ?7.7-5.1%.
en-copyright=
kn-copyright=

en-aut-name=NarihiroNaomasa
en-aut-sei=Narihiro
en-aut-mei=Naomasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OitaMasataka
en-aut-sei=Oita
en-aut-mei=Masataka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakedaYoshihiro
en-aut-sei=Takeda
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Health Sciences, Department of Radiological Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Graduate School of Interdisciplinary Sciences and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Health Sciences, Department of Radiological Technology, Okayama University
kn-affil=
en-keyword=optically stimulated luminescent dosimeter
kn-keyword=optically stimulated luminescent dosimeter
en-keyword=radiotherapy
kn-keyword=radiotherapy
en-keyword=oblique surface dose
kn-keyword=oblique surface dose
en-keyword=high-energy X-ray therapy
kn-keyword=high-energy X-ray therapy
en-keyword=angular dependence
kn-keyword=angular dependence
END

start-ver=1.4
cd-journal=joma
no-vol=529
cd-vols=
no-issue=7
article-no=
start-page=1372
end-page=1390
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Variation of pro‐vasopressin processing in parvocellular and magnocellular neurons in the paraventricular nucleus of the hypothalamus: Evidence from the vasopressin‐related glycopeptide copeptin
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Arginine vasopressin (AVP) is synthesized in parvocellular‐ and magnocellular neuroendocrine neurons in the paraventricular nucleus (PVN) of the hypothalamus. Whereas magnocellular AVP neurons project primarily to the posterior pituitary, parvocellular AVP neurons project to the median eminence (ME) and to extrahypothalamic areas. The AVP gene encodes pre‐pro‐AVP that comprises the signal peptide, AVP, neurophysin (NPII), and a copeptin glycopeptide. In the present study, we used an N‐terminal copeptin antiserum to examine copeptin expression in magnocellular and parvocellular neurons in the hypothalamus in the mouse, rat, and macaque monkey. Although magnocellular NPII‐expressing neurons exhibited strong N‐terminal copeptin immunoreactivity in all three species, a great majority (~90%) of parvocellular neurons that expressed NPII was devoid of copeptin immunoreactivity in the mouse, and in approximately half (~53%) of them in the rat, whereas in monkey hypothalamus, virtually all NPII‐immunoreactive parvocellular neurons contained strong copeptin immunoreactivity. Immunoelectron microscopy in the mouse clearly showed copeptin‐immunoreactivity co‐localized with NPII‐immunoreactivity in neurosecretory vesicles in the internal layer of the ME and posterior pituitary, but not in the external layer of the ME. Intracerebroventricular administration of a prohormone convertase inhibitor, hexa‐d‐arginine amide resulted in a marked reduction of copeptin‐immunoreactivity in the NPII‐immunoreactive magnocellular PVN neurons in the mouse, suggesting that low protease activity and incomplete processing of pro‐AVP could explain the disproportionally low levels of N‐terminal copeptin expression in rodent AVP (NPII)‐expressing parvocellular neurons. Physiologic and phylogenetic aspects of copeptin expression among neuroendocrine neurons require further exploration.
en-copyright=
kn-copyright=

en-aut-name=KawakamiNatsuko
en-aut-sei=Kawakami
en-aut-mei=Natsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OtuboAkito
en-aut-sei=Otubo
en-aut-mei=Akito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MaejimaSho
en-aut-sei=Maejima
en-aut-mei=Sho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TalukderAshraf H.
en-aut-sei=Talukder
en-aut-mei=Ashraf H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SatohKeita
en-aut-sei=Satoh
en-aut-mei=Keita
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OtiTakumi
en-aut-sei=Oti
en-aut-mei=Takumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakanamiKeiko
en-aut-sei=Takanami
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=UedaYasumasa
en-aut-sei=Ueda
en-aut-mei=Yasumasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=ItoiKeiichi
en-aut-sei=Itoi
en-aut-mei=Keiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MorrisJohn F.
en-aut-sei=Morris
en-aut-mei=John F.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SakamotoTatsuya
en-aut-sei=Sakamoto
en-aut-mei=Tatsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=SakamotoHirotaka
en-aut-sei=Sakamoto
en-aut-mei=Hirotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Laboratory of Information Biology, Graduate School of Information Sciences, Tohoku University
kn-affil=

affil-num=5
en-affil=Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=6
en-affil=Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=7
en-affil=Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Physiology, Kyoto Prefectural University of Medicine
kn-affil=

affil-num=9
en-affil=Laboratory of Information Biology, Graduate School of Information Sciences, Tohoku University
kn-affil=

affil-num=10
en-affil=Department of Physiology, Anatomy and Genetics, University of Oxford
kn-affil=

affil-num=11
en-affil=Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=12
en-affil=Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=copeptin
kn-keyword=copeptin
en-keyword=hypothalamo‐pituitary?adrenal system
kn-keyword=hypothalamo‐pituitary?adrenal system
en-keyword=immunohistochemistry
kn-keyword=immunohistochemistry
en-keyword=paraventricular nucleus of the hypothalamus
kn-keyword=paraventricular nucleus of the hypothalamus
en-keyword=processing
kn-keyword=processing
en-keyword=vasopressin
kn-keyword=vasopressin
en-keyword=RRID: AB_2722604
kn-keyword=RRID: AB_2722604
en-keyword=RRID: AB_2061966
kn-keyword=RRID: AB_2061966
en-keyword=RRID: AB_2314234
kn-keyword=RRID: AB_2314234
en-keyword=RRID: AB_10013361
kn-keyword=RRID: AB_10013361
en-keyword=RRID: AB_2313960
kn-keyword=RRID: AB_2313960
en-keyword=RRID: AB_2722605
kn-keyword=RRID: AB_2722605
en-keyword=RRID: AB_90782
kn-keyword=RRID: AB_90782
END

start-ver=1.4
cd-journal=joma
no-vol=85
cd-vols=
no-issue=9
article-no=
start-page=2737
end-page=2744
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200825
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A comparative study of the antioxidant profiles of olive fruit and leaf extracts against five reactive oxygen species as measured with a multiple free‐radical scavenging method
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Olive fruits and leaves are recognized to have great potential as natural sources of antioxidants. The major phenolic antioxidant component in these plant tissues is oleuropein. The antioxidant activity of olive fruits and leaves was evaluated in this study using multiple free‐radical scavenging (MULTIS) methods, wherein we determined the scavenging abilities of different extracts against five reactive oxygen species (ROS; HO?, O2??, RO?, t‐BuOO?, and 1O2). Raw olive fruits taste bitter and are inedible without undergoing a debittering treatment. Following the NaOH‐debittering process, the radical scavenging activity of olives decreased by 90%. The MULTIS measurements indicated that oleuropein and hydroxytyrosol are responsible for the radical scavenging activity of olive fruits. Furthermore, we evaluated the radical scavenging profiles of olive leaf extracts against five ROS and found significant seasonal variations in their antioxidant activities. Leaves picked in August possessed greater radical scavenging abilities (180% to 410% for different ROS) than those picked in the cold season (December and February). In roasted olive leaves, we found marked increases (230% to 300% and 180% to 220%) in the antioxidant activities of Maillard reaction products against RO? and t‐BuOO?, respectively. This study presented a useful comparative analysis of the antioxidant capacities of food against various types of ROS. 
en-copyright=
kn-copyright=

en-aut-name=SueishiYoshimi
en-aut-sei=Sueishi
en-aut-mei=Yoshimi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NiiRisako
en-aut-sei=Nii
en-aut-mei=Risako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Chemistry, Faculty of Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Chemistry, Faculty of Science, Okayama University
kn-affil=
en-keyword=antioxidant capacity
kn-keyword=antioxidant capacity
en-keyword=fruit extract
kn-keyword=fruit extract
en-keyword=leaf extract
kn-keyword=leaf extract
en-keyword=MULTIS
kn-keyword=MULTIS
en-keyword=olive
kn-keyword=olive
END

start-ver=1.4
cd-journal=joma
no-vol=1
cd-vols=
no-issue=
article-no=
start-page=100001
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200720
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Dicer monitoring in a model filamentous fungus host, Cryphonectria parasitica
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The ascomycete Cryphonectria parasitica has served as a model filamentous fungus for studying virus host interactions because of its susceptibility to diverse viruses, its genetic manipulability and the availability of many biological and molecular tools. Cryphonectria prasitica is known to activate antiviral RNA silencing upon infection by some viruses via transcriptional up-regulation of key RNA silencing genes. Here, utilizing a newly developed GFP-based reporter system to monitor dicer-like 2 (dcl2) transcript levels, we show different levels of antiviral RNA silencing activation by different viruses. Some viruses such as mycoreovirus 1, a suppressor-lacking mutant of Cryphonectria hypovirus 1 (CHV1-Δp69) and Rosellinia necatrix partitivirus 11 (RnPV11) highly induced RNA silencing, while others such as CHV3, Rosellinia necatrix victorivirus 1 and RnPV19 did not. There was considerable variation in dcl2 induction by different members within the family Hypoviridae with positive-sense single-stranded RNA genomes or Partitiviridae with double-stranded RNA genomes. Northern blotting and an in vitro Dicer assay developed recently by us using mycelial homogenates validated the reporter assay results for several representative virus strains. Taken together, this study represents a development in the monitoring of Dicer activity in virus-infected C. parasitica.
en-copyright=
kn-copyright=

en-aut-name=AuliaAnnisa
en-aut-sei=Aulia
en-aut-mei=Annisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TabaraMidori
en-aut-sei=Tabara
en-aut-mei=Midori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TelengechPaul
en-aut-sei=Telengech
en-aut-mei=Paul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FukuharaToshiyuki
en-aut-sei=Fukuhara
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SuzukiNobuhiro
en-aut-sei=Suzuki
en-aut-mei=Nobuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil=Tokyo University of Agriculture and Technology, Department of Applied Biological Sciences
kn-affil=

affil-num=3
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=4
en-affil=Tokyo University of Agriculture and Technology, Department of Applied Biological Sciences
kn-affil=

affil-num=5
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=Dicer
kn-keyword=Dicer
en-keyword=RNA silencing
kn-keyword=RNA silencing
en-keyword=Fungal virus
kn-keyword=Fungal virus
en-keyword=RNA virus
kn-keyword=RNA virus
en-keyword=Antiviral defense
kn-keyword=Antiviral defense
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=4
article-no=
start-page=335
end-page=343
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202008
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Recurrence of Solitary Fibrous Tumor/Hemangiopericytoma Could Be Predicted by Ki-67 Regardless of Its Origin
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Since the discovery of the NAB2-STAT6 gene fusion in 2013, solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) have been considered the same disease. STAT6 nuclear stain is approved as a highly sensitive and specific marker to diagnose SFT/HPC from other tumors with similar histology. As the next step, detection of fusion variants that may predict clinical malignancy of SFT/HPC has been attempted. However, no fusion variants with a clear relation to malignancy have been identified. In this study, the clinical and histological backgrounds of 23 Japanese patients diagnosed with SFT/HPC from 2000 to 2019 at Kochi University Hospital were examined to identify factors potentially related to recurrence. A significant relationship to recurrence was detected for mitosis ? 1/10 HPF (400×), necrosis, and Ki-67>5%. These findings indicate that a deliberate investigation of histological features such as mitosis and necrosis is crucial for the clinical observation of SFT/ HPC patients. In addition, Ki-67 was revealed to be a useful parameter to predict recurrence in SFT/HPC patients.
en-copyright=
kn-copyright=

en-aut-name=YamamotoYumiko
en-aut-sei=Yamamoto
en-aut-mei=Yumiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HayashiYoshihiro
en-aut-sei=Hayashi
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MurakamiIchiro
en-aut-sei=Murakami
en-aut-mei=Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Diagnostic Pathology, Kochi University
kn-affil=

affil-num=2
en-affil=Department of Equipment of Support Planning Office, Kochi University
kn-affil=

affil-num=3
en-affil=Department of Diagnostic Pathology, Kochi University
kn-affil=
en-keyword=solitary fibrous tumor
kn-keyword=solitary fibrous tumor
en-keyword=hemangiopericytoma
kn-keyword=hemangiopericytoma
en-keyword=Ki-67
kn-keyword=Ki-67
en-keyword=NAB2-STAT6
kn-keyword=NAB2-STAT6
en-keyword=WHO classification
kn-keyword=WHO classification
en-keyword=WHO grading criteria
kn-keyword=WHO grading criteria
en-keyword=Marseille Grading System
kn-keyword=Marseille Grading System
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=1
article-no=
start-page=12581
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200728
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The use of primary patient-derived organoids for drug sensitivity and resistance testing could play an important role in precision cancer medicine. We developed expandable ovarian cancer organoids in<3 weeks; these organoids captured the characteristics of histological cancer subtypes and replicated the mutational landscape of the primary tumours. Seven pairs of organoids (3 high-grade serous, 1 clear cell, 3 endometrioid) and original tumours shared 59.5% (36.1-73.1%) of the variants identified. Copy number variations were also similar among organoids and primary tumours. The organoid that harboured the BRCA1 pathogenic variant (p.L63*) showed a higher sensitivity to PARP inhibitor, olaparib, as well as to platinum drugs compared to the other organoids, whereas an organoid derived from clear cell ovarian cancer was resistant to conventional drugs for ovarian cancer, namely platinum drugs, paclitaxel, and olaparib. The overall success rate of primary organoid culture, including those of various histological subtypes, was 80% (28/35). Our data show that patient-derived organoids are suitable physiological ex vivo cancer models that can be used to screen effective personalised ovarian cancer drugs.
en-copyright=
kn-copyright=

en-aut-name=NankiYoshiko
en-aut-sei=Nanki
en-aut-mei=Yoshiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ChiyodaTatsuyuki
en-aut-sei=Chiyoda
en-aut-mei=Tatsuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HirasawaAkira
en-aut-sei=Hirasawa
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OokuboAki
en-aut-sei=Ookubo
en-aut-mei=Aki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ItohManabu
en-aut-sei=Itoh
en-aut-mei=Manabu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=UenoMasaru
en-aut-sei=Ueno
en-aut-mei=Masaru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=AkahaneTomoko
en-aut-sei=Akahane
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KameyamaKaori
en-aut-sei=Kameyama
en-aut-mei=Kaori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YamagamiWataru
en-aut-sei=Yamagami
en-aut-mei=Wataru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KataokaFumio
en-aut-sei=Kataoka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=AokiDaisuke
en-aut-sei=Aoki
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Obstetrics and Gynecology, Keio University School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Obstetrics and Gynecology, Keio University School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Clinical Genomic Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=JSR?Keio University Medical and Chemical Innovation Center (JKiC), JSR Corp.
kn-affil=

affil-num=5
en-affil=JSR?Keio University Medical and Chemical Innovation Center (JKiC), JSR Corp.
kn-affil=

affil-num=6
en-affil=JSR?Keio University Medical and Chemical Innovation Center (JKiC), JSR Corp.
kn-affil=

affil-num=7
en-affil=JSR?Keio University Medical and Chemical Innovation Center (JKiC), Keio University School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Pathology, Keio University School of Medicine
kn-affil=

affil-num=9
en-affil=Department of Obstetrics and Gynecology, Keio University School of Medicine
kn-affil=

affil-num=10
en-affil=Department of Obstetrics and Gynecology, Keio University School of Medicine
kn-affil=

affil-num=11
en-affil=Department of Obstetrics and Gynecology, Keio University School of Medicine
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200615
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Ambiguous species boundaries: Hybridization and morphological variation in two closely relatedRubusspecies along altitudinal gradients
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Although hybridization frequently occurs among plant species, hybrid zones of divergent lineages formed at species boundaries are less common and may not be apparent in later generations of hybrids with more parental-like phenotypes, as a consequence of backcrossing. To determine the effects of dispersal and selection on species boundaries, we compared clines in leaf traits and molecular hybrid index along two hybrid zones on Yakushima Island, Japan, in which a temperate (Rubus palmatus) and subtropical (Rubus grayanus) species of wild raspberry are found. Leaf sinus depth in the two hybrid zones had narrower clines at 600 m a.s.l. than the molecular hybrid index and common garden tests confirmed that some leaf traits, including leaf sinus depth that is a major trait used in species identification, are genetically divergent between these closely related species. The sharp transition in leaf phenotypic traits compared to molecular markers indicated divergent selection pressure on the hybrid zone structure. We suggest that species boundaries based on neutral molecular data may differ from those based on observed morphological traits.	
en-copyright=
kn-copyright=

en-aut-name=MimuraMakiko
en-aut-sei=Mimura
en-aut-mei=Makiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SugaMihoko
en-aut-sei=Suga
en-aut-mei=Mihoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Biology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Agriculture, Tamagawa University
kn-affil=
en-keyword=hybrid zone
kn-keyword=hybrid zone
en-keyword=introgression
kn-keyword=introgression
en-keyword=morphology
kn-keyword=morphology
en-keyword=species identification
kn-keyword=species identification
END

start-ver=1.4
cd-journal=joma
no-vol=130
cd-vols=
no-issue=1
article-no=
start-page=34
end-page=40
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200507
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Genetic variation and phenotypic plasticity in circadian rhythms in an armed beetle, Gnatocerus cornutus (Tenebrionidae)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Circadian rhythms, their free-running periods and the power of the rhythms are often used as indicators of biological clocks, and there is evidence that the free-running periods of circadian rhythms are not affected by environmental factors, such as temperature. However, there are few studies of environmental effects on the power of the rhythms, and it is not clear whether temperature compensation is universal. Additionally, genetic variation and phenotypic plasticity in biological clocks are important for understanding the evolution of biological rhythms, but genetic and plastic effects are rarely investigated. Here, we used 18 isofemale lines (genotypes) of Gnatocerus cornutus to assess rhythms of locomotor activity, while also testing for temperature effects. We found that total activity and the power of the circadian rhythm were affected by interactions between sex and genotype or between sex, genotype and temperature. The males tended to be more active and showed greater increases in activity, but this effect varied across both genotypes and temperatures. The period of activity varied only by genotype and was thus independent of temperature. The complicated genotype?sex?environment interactions we recorded stress the importance of investigating circadian activity in more integrated ways.
en-copyright=
kn-copyright=

en-aut-name=MatsumuraKentarou
en-aut-sei=Matsumura
en-aut-mei=Kentarou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AbeMasato S
en-aut-sei=Abe
en-aut-mei=Masato S
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SharmaManmohan D
en-aut-sei=Sharma
en-aut-mei=Manmohan D
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HoskenDavid J
en-aut-sei=Hosken
en-aut-mei=David J
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YoshiiTaishi
en-aut-sei=Yoshii
en-aut-mei=Taishi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MiyatakeTakahisa
en-aut-sei=Miyatake
en-aut-mei=Takahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Center for Advanced Intelligence Project, RIKEN
kn-affil=

affil-num=3
en-affil=Centre for Ecology and Conservation, School of Biosciences, University of Exeter
kn-affil=

affil-num=4
en-affil=Centre for Ecology and Conservation, School of Biosciences, University of Exeter
kn-affil=

affil-num=5
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=circadian rhythm
kn-keyword=circadian rhythm
en-keyword=Gnatocerus cornutus
kn-keyword=Gnatocerus cornutus
en-keyword=isofemale line
kn-keyword=isofemale line
en-keyword=power of circadian rhythm
kn-keyword=power of circadian rhythm
END

start-ver=1.4
cd-journal=joma
no-vol=530
cd-vols=
no-issue=
article-no=
start-page=115887
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191023
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Grain boundary diffusion of W in lower mantle phase with implications for isotopic heterogeneity in oceanic island basalts by core-mantle interactions
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Tungsten isotopes provide important constraints on the ocean-island basalt (OIB) source regions. Recent analyses of μ182W in modern basalts with high 3He/4He originating from the core-mantle boundary region reveal two distinct features: positive μ182W in Phanerozoic flood basalts indicating the presence of primordial reservoir, and negative μ182W in modern OIBs. One possibility to produce large variations in μ182W is interaction between the mantle and outer core. Here, we report grain boundary diffusion of W in lower mantle phases. High pressure experimental results show that grain boundary diffusion of W is fast and strongly temperature dependent. Over Earth's history, diffusive transport of W from the core to the lowermost mantle may have led to significant modification of the W isotopic composition of the lower mantle at length scales exceeding one kilometer. Such grain boundary diffusion can lead to large variations in μ182W in modern basalts as a function of the distance of their source regions from the core mantle boundary. Modern oceanic island basalts from Hawaii, Samoa and Iceland exhibit negative μ182W and likely originated from the modified isotope region just above the core-mantle boundary, whereas those with positive μ182W could be derived from the thick Large Low Shear Velocity Provinces (LLSVPs) far from the core-mantle boundary (CMB). When highly-oxidized slabs accumulate at the CMB oxidizing the outer core at the interface, a large W flux with negative μ182W can be added to the silicate mantle. As a result, the source region of the OIB would be effectively modified to a negative μ182W.
en-copyright=
kn-copyright=

en-aut-name=YoshinoTakashi
en-aut-sei=Yoshino
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MakinoYoshiki
en-aut-sei=Makino
en-aut-mei=Yoshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SuzukiToshihiro
en-aut-sei=Suzuki
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HirataTakafumi
en-aut-sei=Hirata
en-aut-mei=Takafumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=2
en-affil=Geochemical Research Center, The University of Tokyo
kn-affil=

affil-num=3
en-affil=Geochemical Research Center, The University of Tokyo
kn-affil=

affil-num=4
en-affil=Geochemical Research Center, The University of Tokyo
kn-affil=
en-keyword=core mantle interaction
kn-keyword=core mantle interaction
en-keyword=grain boundary diffusion
kn-keyword=grain boundary diffusion
en-keyword=high pressure experiment
kn-keyword=high pressure experiment
en-keyword=postspinel
kn-keyword=postspinel
en-keyword=W isotope
kn-keyword=W isotope
en-keyword=core mantle boundary
kn-keyword=core mantle boundary
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=2
article-no=
start-page=630
end-page=633
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Pediatric Living Donor Liver Transplantation for Congenital Absence of the Portal Vein With Pulmonary Hypertension: A Case Report
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Few reports of liver transplantation exist in patients with congenital absence of the portal vein and pulmonary hypertension. Living donor liver transplantation is usually performed before exacerbation of pulmonary hypertension. A 7-year-old girl (height: 131.5 cm; weight: 27.4 kg) with congenital absence of the portal vein was diagnosed with pulmonary hypertension (mean pulmonary artery pressure 35 mm Hg), and liver transplantation was planned before exacerbation of pulmonary hypertension. We successfully managed her hemodynamic parameters using low-dose dopamine and noradrenaline under monitoring of arterial blood pressure, central venous pressure, cardiac output, and stroke volume variation. Anesthesia was maintained using air-oxygen-sevoflurane and remifentanil 0.1 to 0.6 μg?kg-1?min-1. It is necessary to understand the potential perioperative complications in such cases and to adopt a multidisciplinary team approach in terms of the timing of transplantation and readiness to deal with exacerbation of pulmonary hypertension. 
en-copyright=
kn-copyright=

en-aut-name=MatsumotoNaohisa
en-aut-sei=Matsumoto
en-aut-mei=Naohisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsusakiTakashi
en-aut-sei=Matsusaki
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HiroiKazumasa
en-aut-sei=Hiroi
en-aut-mei=Kazumasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KakuRyuji
en-aut-sei=Kaku
en-aut-mei=Ryuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YoshidaRyuichi
en-aut-sei=Yoshida
en-aut-mei=Ryuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=UmedaYuzo
en-aut-sei=Umeda
en-aut-mei=Yuzo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YagiTakahito
en-aut-sei=Yagi
en-aut-mei=Takahito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MorimatsuHiroshi
en-aut-sei=Morimatsu
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil= Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil= Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil= Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=

affil-num=4
en-affil= Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=
kn-affil=

affil-num=8
en-affil= Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=220
cd-vols=
no-issue=1
article-no=
start-page=190
end-page=200
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Deformation of rhyolite lava crust associated with intermittent inner flow of lava: palaeomagnetic evidence
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A palaeomagnetic study has been conducted to examine the deformation of thick crusts of rhyolite lava while its inner portions continue to flow. The Sanukayama rhyolite lava, which erupted in the Pleistocene in Kozushima Island, Japan, was chosen as the investigation site because of its well-exposed vertical lithofacies variations classified into three distinct zones (pumiceous, obsidian and crystalline). The targets of this study are the pumiceous and obsidian zones, which constitute the crust of the lava. Thermal demagnetization reveals three remanent magnetization components from the pumiceous and obsidian samples but only a single magnetization component from the inner crystalline rhyolite samples. Alternating field demagnetization is ineffective in isolating the magnetization components in the pumiceous and obsidian samples. The multiple components of remanent magnetization of the crust are interpreted to have been acquired during cooling as thermoremanent magnetizations. We suspect intermittent lava transport of the inner portions, the primary mode of rhyolite lava advancement, to be responsible for the presence of multiple components in pumice and obsidian of the lava crust. When the inner portions of the lava retain mobility to flow out of the crust, the solidified crust of the lava surface below the magnetite Curie temperature remains susceptible to deformation. Analysis of palaeomagnetic directions from the crust allows the deformation of the crust to be described in terms of rotation. Although the mode of rhyolite lava advancement is not well understood, because of its infrequent occurrence, our observations offer an important insight on how the mobile part of the lava is associated with the deformation of the crust during continued lava advance.
en-copyright=
kn-copyright=

en-aut-name=UnoKoji
en-aut-sei=Uno
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FurukawaKuniyuki
en-aut-sei=Furukawa
en-aut-mei=Kuniyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakaiKotaro
en-aut-sei=Nakai
en-aut-mei=Kotaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KamioTakuma
en-aut-sei=Kamio
en-aut-mei=Takuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KanamaruTatsuo
en-aut-sei=Kanamaru
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Earth Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Faculty of Business Administration, Aichi University
kn-affil=

affil-num=3
en-affil=Department of Earth Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Earth Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Earth and Environmental Sciences, Nihon University
kn-affil=
en-keyword=Asia
kn-keyword=Asia
en-keyword=Palaeomagnetism
kn-keyword=Palaeomagnetism
en-keyword=Rock and mineral magnetism
kn-keyword=Rock and mineral magnetism
en-keyword=Volcanic hazards and risks
kn-keyword=Volcanic hazards and risks
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=1
article-no=
start-page=25
end-page=36
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Interdisciplinary ESD lesson study for the university students with attention to the difference of climate and seasonal feeling in “summer” among Germany, northern Europe and Japan
kn-title=ドイツ・北欧と日本の「夏」の気候や季節感の違いに注目して音楽と連携した大学での学際的ESD授業開発
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Climatological features and seasonal feeling in the season called by the same word such as “summer”would be rather different from region to region. Comparison of these features among the different regions, including the regions which are not so familiar to the students, would help to promote their fundamental ESD literacy, especially relating to the “Understanding of heterogeneous others”. Based on that concept, this paper will report an interdisciplinary lesson study for the university students on a theme how different the summertime climate and seasonal feeling among Germany, northern Europe and Japan are. In this study, the lesson practice was made in 2015 and 2018. In both classes, after the lecture on the summertime climate and seasonal feeling in these regions, the students created substitute songs with use of the melody of “Alles neu macht der Mai” (“The May makes all things new”, the same melody as a Japanese school song “Butterfly”) for the comparison between Germany and Japan. As for that between northern Europe, the melody of a Japanese school song “Furu-Sato” (“My country home”) was used for the creation of the substitute songs. It is noted that, not only the seasonal mean temperature or solar radiation condition, but also the features in association with the large day-to-day temperature variation was strongly reflected in the students’ works.
en-copyright=
kn-copyright=

en-aut-name=KATOKuranoshin
en-aut-sei=KATO
en-aut-mei=Kuranoshin
kn-aut-name=加藤内藏進
kn-aut-sei=加藤
kn-aut-mei=内藏進
aut-affil-num=1
ORCID=

en-aut-name=KATOHaruko
en-aut-sei=KATO
en-aut-mei=Haruko
kn-aut-name=加藤晴子
kn-aut-sei=加藤
kn-aut-mei=晴子
aut-affil-num=2
ORCID=

en-aut-name=OTANIKazuo
en-aut-sei=OTANI
en-aut-mei=Kazuo
kn-aut-name=大谷和男
kn-aut-sei=大谷
kn-aut-mei=和男
aut-affil-num=3
ORCID=

en-aut-name=MATSUMOTOKengo
en-aut-sei=MATSUMOTO
en-aut-mei=Kengo
kn-aut-name=松本健吾
kn-aut-sei=松本
kn-aut-mei=健吾
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Education, Okayama University
kn-affil=岡山大学大学院教育学研究科

affil-num=2
en-affil=Faculty of Education, Gufu Shotoku Gakuen University
kn-affil=岐阜聖徳学園大学教育学部

affil-num=3
en-affil=TV Setouchi Broadcasting Co., LTD.
kn-affil=テレビせとうち(株)

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
en-keyword=Interdisciplinary collaboration between climate and cultural understanding education
kn-keyword=Interdisciplinary collaboration between climate and cultural understanding education
en-keyword=ESD
kn-keyword=ESD
en-keyword=Comparative climatology
kn-keyword=Comparative climatology
en-keyword=Regional difference of summer climate
kn-keyword=Regional difference of summer climate
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=24
article-no=
start-page=5130
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191216
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Geographical Differences and the National Meeting Effect in Patients with Out-of-Hospital Cardiac Arrests: A JCS-ReSS Study Report
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The "national meeting effect" refers to worse patient outcomes when medical professionals attend academic meetings and hospitals have reduced staffing. The aim of this study was to examine differences in outcomes of patients with out-of-hospital cardiac arrest (OHCA) admitted during, before, and after meeting days according to meeting location and considering regional variation of outcomes, which has not been investigated in previous studies. Using data from a nationwide, prospective, population-based, observational study in Japan, we analyzed adult OHCA patients who underwent resuscitation attempts between 2011 and 2015. Favorable one-month neurological outcomes were compared among patients admitted during the relevant annual meeting dates of three national scientific societies, those admitted on identical days the week before, and those one week after the meeting dates. We developed a multivariate logistic regression model after adjusting for confounding factors, including meeting location and regional variation (better vs. worse outcome areas), using the "during meeting days" group as the reference. A total of 40,849 patients were included in the study, with 14,490, 13,518, and 12,841 patients hospitalized during, before, and after meeting days, respectively. The rates of favorable neurological outcomes during, before, and after meeting days was 1.7, 1.6, and 1.8%, respectively. After adjusting for covariates, favorable neurological outcomes did not differ among the three groups (adjusted OR (95% CI) of the before and after meeting dates groups was 1.03 (0.83-1.28) and 1.01 (0.81-1.26), respectively. The "national meeting effect" did not exist in OHCA patients in Japan, even after comparing data during, before, and after meeting dates and considering meeting location and regional variation.
en-copyright=
kn-copyright=

en-aut-name=YumotoTetsuya
en-aut-sei=Yumoto
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NaitouHiromichi
en-aut-sei=Naitou
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YorifujiTakashi
en-aut-sei=Yorifuji
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TaharaYoshio
en-aut-sei=Tahara
en-aut-mei=Yoshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YonemotoNaohiro
en-aut-sei=Yonemoto
en-aut-mei=Naohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NonogiHiroshi
en-aut-sei=Nonogi
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NagaoKen
en-aut-sei=Nagao
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IkedaTakanori
en-aut-sei=Ikeda
en-aut-mei=Takanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SatoNaoki
en-aut-sei=Sato
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TsutsuiHiroyuki
en-aut-sei=Tsutsui
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
kn-affil=

affil-num=5
en-affil=National Center of Neurology and Psychiatry
kn-affil=

affil-num=6
en-affil=Intensive Care Center, Shizuoka General Hospital
kn-affil=

affil-num=7
en-affil=Cardiovascular Center, Nihon University Hospital
kn-affil=

affil-num=8
en-affil=Department of Cardiovascular Medicine, Toho University Faculty of Medicine
kn-affil=

affil-num=9
en-affil=Cardiovascular Medicine, Kawaguchi Cardiovascular and Respiratory Hospital
kn-affil=

affil-num=10
en-affil=Department of Cardiovascular Medicine, Kyushu University Faculty of Medical Sciences
kn-affil=
en-keyword=out-of-hospital cardiac arrest
kn-keyword=out-of-hospital cardiac arrest
en-keyword=outcome
kn-keyword=outcome
en-keyword=national meeting
kn-keyword=national meeting
en-keyword=cardiopulmonary resuscitation
kn-keyword=cardiopulmonary resuscitation
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=7
article-no=
start-page=783
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190712
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effect of Lubrication and Forging Load on Surface Roughness, Residual Stress, and Deformation of Cold Forging Tools
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Cold forging is a metal forming that which uses localized compressive force at room temperature. During the cold forging process, the tool is subjected to extremely high loads and abrasive wear. Lubrication plays an important role in cold forging to improve product quality and tool life by preventing direct metallic contact. Surface roughness and residual stress also greatly affects the service life of a tool. In this study, variations in surface roughness, residual stress, and specimen deformation with the number of cold forging cycles were investigated under different forging conditions. Specimens that were made of heat-treated SKH51 (59-61 HRC), a high-speed tool steel with a polished working surface, were used. The specimens were subjected to an upsetting process. Compressive residual stress, surface roughness, and specimen deformation showed a positive relationship with the number of forging cycles up to a certain limit and became almost constant in most of the forging conditions. A larger change in residual stress and surface roughness was observed at the center of the specimens in all the forging conditions. The effect of the magnitude of the forging load on the above discussed parameters is large when compared to the effect of the lubrication conditions.
en-copyright=
kn-copyright=

en-aut-name=KarunathilakaNuwan
en-aut-sei=Karunathilaka
en-aut-mei=Nuwan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TadaNaoya
en-aut-sei=Tada
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=UemoriTakeshi
en-aut-sei=Uemori
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HanamitsuRyota
en-aut-sei=Hanamitsu
en-aut-mei=Ryota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujiiMasahiro
en-aut-sei=Fujii
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OmiyaYuya
en-aut-sei=Omiya
en-aut-mei=Yuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KawanoMasahiro
en-aut-sei=Kawano
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=7
en-affil=Zeno Tech Co., Ltd
kn-affil=
en-keyword=cold forging
kn-keyword=cold forging
en-keyword=high-speed tool steel
kn-keyword=high-speed tool steel
en-keyword=lubrication
kn-keyword=lubrication
en-keyword=residual stress
kn-keyword=residual stress
en-keyword=surface roughness
kn-keyword=surface roughness
en-keyword=tool deformation
kn-keyword=tool deformation
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1
article-no=
start-page=65
end-page=72
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202002
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Metabolic Profiling of the Cerebrospinal Fluid in Pediatric Epilepsy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= To characterize metabolic profiles within the central nervous system in epilepsy, we performed gas chromatography-tandem mass spectrometry (GC-MS/MS)-based metabolome analysis of the cerebrospinal fluid (CSF) in pediatric patients with and without epilepsy. The CSF samples obtained from 64 patients were analyzed by GC-MS/MS. Multivariate analyses were performed for two age groups, 0-5 years of age and 6-17 years of age, to elucidate the effects of epilepsy and antiepileptic drugs on the metabolites. In patients aged 0-5 years (22 patients with epilepsy, 13 without epilepsy), epilepsy patients had reduced 2-ketoglutaric acid and elevated pyridoxamine and tyrosine. In patients aged 6-17 years (12 with epilepsy, 17 without epilepsy), epilepsy patients had reduced 1,5-anhydroglucitol. Valproic acid was associated with elevated 2-aminobutyric acid, 2-ketoisocaproic acid, 4-hydroxyproline, acetylglycine, methionine, N-acetylserine, and serine. Reduced energy metabolism and alteration of vitamin B6 metabolism may play a role in epilepsy in young children. The roles of 1,5-anhydroglucitol in epilepsy in older children and in levetiracetam and zonisamide treatment remain to be explained. Valproic acid influenced the levels of amino acids and related metabolites involved in the metabolism of serine, methionine, and leucine.
en-copyright=
kn-copyright=

en-aut-name=AkiyamaTomoyuki
en-aut-sei=Akiyama
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SaigusaDaisuke
en-aut-sei=Saigusa
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HyodoYuki
en-aut-sei=Hyodo
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UmedaKeiko
en-aut-sei=Umeda
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SaijoReina
en-aut-sei=Saijo
en-aut-mei=Reina
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KoshibaSeizo
en-aut-sei=Koshiba
en-aut-mei=Seizo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KobayashiKatsuhiro
en-aut-sei=Kobayashi
en-aut-mei=Katsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Child Neurology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Tohoku Medical Megabank Organization, Tohoku University
kn-affil=

affil-num=3
en-affil=Department of Child Neurology, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Tohoku Medical Megabank Organization, Tohoku University
kn-affil=

affil-num=5
en-affil=Tohoku Medical Megabank Organization, Tohoku University
kn-affil=

affil-num=6
en-affil=Tohoku Medical Megabank Organization, Tohoku University
kn-affil=

affil-num=7
en-affil=Department of Child Neurology, Okayama University Hospital
kn-affil=
en-keyword=antiepileptic drugs
kn-keyword=antiepileptic drugs
en-keyword=gas chromatography-tandem mass spectrometry
kn-keyword=gas chromatography-tandem mass spectrometry
en-keyword=metabolome analysis
kn-keyword=metabolome analysis
en-keyword=metabolomics
kn-keyword=metabolomics
END

start-ver=1.4
cd-journal=joma
no-vol=60
cd-vols=
no-issue=8
article-no=
start-page=1681
end-page=1715
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190912
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Transition from Plume-driven to Plate-driven Magmatism in the Evolution of the Main Ethiopian Rift
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= New K-Ar ages, major and trace element concentrations, and Sr-Nd-Pb isotope data are presented for Oligocene to recent mafic volcanic rocks from the Ethiopian Plateau, the Main Ethiopian Rift (MER), and the Afar depression. Chronological and geochemical data from this study are combined with previously published datasets to reveal secular variations in magmatism throughout the entire Ethiopian volcanic region. The mafic lavas in these regions show variability in terms of silica-saturation (i.e. alkaline and sub-alkaline series) and extent of differentiation (mafic through intermediate to felsic). The P-T conditions of melting, estimated using the least differentiated basalts, reveal a secular decrease in the mantle potential temperature, from when the flood basalt magmas erupted (up to 1600 degrees C) to the time of the rift-related magmatism (<1500 degrees C). Variations in the Sr-Nd-Pb isotopic compositions of the mafic lavas can account for the involvement of multiple end-member components. The relative contributions of these end-member components vary in space and time owing to changes in the thermal condition of the asthenosphere and the thickness of the lithosphere. The evolution of the Ethiopian rift is caused by a transition from plume-driven to plate-driven mantle upwelling, although the present-day mantle beneath the MER and the Afar depression is still warmer than normal asthenosphere.
en-copyright=
kn-copyright=

en-aut-name=FeyissaDejene Hailemariam
en-aut-sei=Feyissa
en-aut-mei=Dejene Hailemariam
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KitagawaHiroshi
en-aut-sei=Kitagawa
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=BizunehTesfaye Demissie
en-aut-sei=Bizuneh
en-aut-mei=Tesfaye Demissie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TanakaRyoji
en-aut-sei=Tanaka
en-aut-mei=Ryoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KabetoKurkura
en-aut-sei=Kabeto
en-aut-mei=Kurkura
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NakamuraEizo
en-aut-sei=Nakamura
en-aut-mei=Eizo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=2
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=3
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=4
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=5
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=6
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=
en-keyword=Ethiopian Plateau
kn-keyword=Ethiopian Plateau
en-keyword=Ethiopian rift
kn-keyword=Ethiopian rift
en-keyword=Afar depression
kn-keyword=Afar depression
en-keyword=mantle source
kn-keyword=mantle source
en-keyword=mantle melting
kn-keyword=mantle melting
END

start-ver=1.4
cd-journal=joma
no-vol=38
cd-vols=
no-issue=1
article-no=
start-page=14
end-page=22
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Individual and Sexual Differences in Time to Habituate to Food-stimuli Presentation of Potential Prey in Hyla japonica
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The traits of many animal species exhibit individual and sexual differences. Individuals repeatedly receiving a stimulus without harm become habituated to it. However, few studies have been conducted on individual and sexual differences in the process of habituation to unfamiliar food stimuli. Therefore, we hypothesized that individual differences or sexual differences would be observed in reaction to an in-lab food-stimuli presentation of potential prey items (after that "food stimuli"). We tested the hypothesis using the Japanese tree frog Hyla japonica, and conducted statistical analyses of these results. A generalized linear model (GLM) showed individual and sexual differences in time to get used to the food stimuli. Females habituated more rapidly to food stimuli than males. The difference between sexes is discussed in view of two ultimate and one proximate reasons.
en-copyright=
kn-copyright=

en-aut-name=TanabeShintaro
en-aut-sei=Tanabe
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KasuyaEiiti
en-aut-sei=Kasuya
en-aut-mei=Eiiti
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MiyatakeTakahisa
en-aut-sei=Miyatake
en-aut-mei=Takahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Biology, Faculty of Sciences, Kyushu University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and life Science, Okayama University
kn-affil=
en-keyword=Habituation
kn-keyword=Habituation
en-keyword=Hyla japonica
kn-keyword=Hyla japonica
en-keyword=individual variation
kn-keyword=individual variation
en-keyword=sexual difference
kn-keyword=sexual difference
en-keyword=predation
kn-keyword=predation
END

start-ver=1.4
cd-journal=joma
no-vol=109
cd-vols=
no-issue=
article-no=
start-page=37
end-page=40
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Sexuality in plants, unveiled from genome evolution
kn-title=ゲノム進化が紐解く植物の性決定
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Sexual polymorphism, a main strategy to maintain genetic diversity within a species, has long been a major focus in biology. Notwithstanding, in plants, evolution of sexual systems and mechanisms underlying these transitions have been little unveiled. We have elucidated the molecular mechanism of sex determination in persimmons (Diospyros spp.), where the Y-encoded smRNA gene OGI can repress the female-determining gene MeGI, and also in kiwifruits (Actinidia spp.), where the Y-encoded two sex determinants, Shy Girl and Friendly Boy, control gynoecium and androecium development, respectively. Although the molecular functions of these determinants are distinct, they have common evolutionary scenarios involving transitions of sexual systems. In persimmon, a recent genome triplication (hexaploidization) in cultivated persimmon (D. kaki) derived “flexible” sexuality via establishing epigenetic layers on the two sex determinants. On the other hand, an ancient Diospyros-specific paleo-genome duplication (paleo-tetraploidization) enabled neofunctionalization in the proto-MeGI, via positive selection, to establish a new function as a sex determinant. In kiwifruit, one of the two sex determinants, Shy Girl, was derived from neofunctionalization via Actinidia-specific duplication event. These findings exemplify how plant-specific numerous duplication events can drive flexible genetic material whose variation can be selected for development of new sexual systems.
en-copyright=
kn-copyright=

en-aut-name=AkagiTakashi
en-aut-sei=Akagi
en-aut-mei=Takashi
kn-aut-name=赤木剛士
kn-aut-sei=赤木
kn-aut-mei=剛士
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
en-keyword=Sex determination
kn-keyword=Sex determination
en-keyword=Sex chromosome
kn-keyword=Sex chromosome
en-keyword=Polyploidization
kn-keyword=Polyploidization
en-keyword=Genome evolution
kn-keyword=Genome evolution
en-keyword=Tree crops
kn-keyword=Tree crops
END

start-ver=1.4
cd-journal=joma
no-vol=109
cd-vols=
no-issue=
article-no=
start-page=7
end-page=11
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Mathematical analysis of copy number variation of 2 μ-based plasmids in yeast cells
kn-title=酵母2μプラスミドのコピー数変動の数理的解析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= 　Plasmids with the 2 μ plasmid origin are commonly-used in the genetic engineering of the budding yeast Saccharomyces cerevisiae. Intracellular copy numbers of 2 μ plasmids are different depending on the genes inserted into the plasmids. This difference is thought to occur from the difference in the growth efficiency （fitness） produced by the positive- and negative-selection biases of genes inserted in the plasmid. In this study, we made a mathematical model based on this assumption. Computational simulations of the model validated that copy numbers of the plasmids are rapidly settled depending on the fitness created by the gene on the plasmid. The copy number of a plasmid only contains a bias to keep the plasmid in a single copy became average 20copies per cell when the plasmid is randomly distributed, suggesting that no positive distribution mechanism is required for a plasmid to become multicopy.
en-copyright=
kn-copyright=

en-aut-name=SaekiNozomu
en-aut-sei=Saeki
en-aut-mei=Nozomu
kn-aut-name=佐伯望
kn-aut-sei=佐伯
kn-aut-mei=望
aut-affil-num=1
ORCID=

en-aut-name=MoriyaHisao
en-aut-sei=Moriya
en-aut-mei=Hisao
kn-aut-name=守屋央朗
kn-aut-sei=守屋
kn-aut-mei=央朗
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University)
kn-affil=岡山大学大学院　環境生命科学研究科

affil-num=2
en-affil= Research Core for Interdisciplinary Sciences, Okayama University
kn-affil=異分野融合先端研究コア
en-keyword=yeast
kn-keyword=yeast
en-keyword=2 μ plasmid
kn-keyword=2 μ plasmid
en-keyword=mathematical model
kn-keyword=mathematical model
END

start-ver=1.4
cd-journal=joma
no-vol=36
cd-vols=
no-issue=2
article-no=
start-page=161
end-page=168
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180404
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Responses to relaxed and reverse selection in strains artificially selected for duration of death-feigning behavior in the red flour beetle, Tribolium castaneum
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Divergent lines selected artificially for many generations make it possible to answer two questions: (1) whether genetic variation still exists within the selected population; and (2) whether the selection itself is costly for the selected strain. In previous studies, the red flour beetle Tribolium castaneum was divergently selected artificially for duration of death-feigning, and strains selected for longer (L-strain) and shorter (S-strain) durations of death-feigning have been established (Miyatake et al. 2004, 2008). Because the selection experiments have been conducted for more than 27 generations, genetic variation may be eroded. Furthermore, because another previous study reported physiological costs to L-strains, the L-strains selected artificially for longer duration of death-feigning may have suffered more costs than the S-strains. In the present study, therefore, we relaxed the selection pressure after the 27th or 30th generation of S- and L-strains. We also carried out reverse selection during the most recent eight generations of S- and L-strains. The results showed that each strain clearly responded to relaxation of selection and reverse selection, suggesting that (1) additive genetic variation still existed in both strains after long-term selection, and (2) selection for shorter and longer duration of death-feigning was costly. These results suggest that anti-predator behavior is controlled by many loci, and longer or shorter duration of death-feigning is costly in a laboratory without predators.
en-copyright=
kn-copyright=

en-aut-name=MatsumuraKentarou
en-aut-sei=Matsumura
en-aut-mei=Kentarou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MiyatakeTakahisa
en-aut-sei=Miyatake
en-aut-mei=Takahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=Artificial selection
kn-keyword=Artificial selection
en-keyword=Quantitative trait
kn-keyword=Quantitative trait
en-keyword=Relaxation of selection
kn-keyword=Relaxation of selection
en-keyword=Reverse selection
kn-keyword=Reverse selection
en-keyword=Tonic immobility
kn-keyword=Tonic immobility
en-keyword=Tribolium castaneum
kn-keyword=Tribolium castaneum
END

start-ver=1.4
cd-journal=joma
no-vol=252
cd-vols=
no-issue=
article-no=
start-page=107
end-page=125
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190501
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Lithium- and oxygen-isotope compositions of chondrule constituents in the Allende meteorite
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= We report in situ ion-microprobe analyses of Li- and O-isotope compositions for olivine, low-Ca pyroxene, high-Ca pyroxene, and chondrule mesostasis/plagioclase in nine chondrules from the Allende CV3 chondrite. Based on their mineralogy and O-isotope compositions, we infer that the chondrule mesostasis/plagioclase and ferroan olivine rims were extensively modified or formed during metasomatic alteration and metamorphism on the Allende parent asteroid. We excluded these minerals in order to determine the correlations between Li and both O and the chemical compositions of olivines and low-Ca pyroxenes in the chondrules and their igneous rims. Based on the O-isotope composition of the olivines, nine chondrules were divided into three groups. Average Δ17O of olivines (Fo>65) in group 1 and 2 chondrules are ?5.3?±?0.4 and ?6.2?±?0.4‰, respectively. Group 3 chondrules are characterized by the presence of 16O-rich relict grains and the Δ17O of their olivines range from ?23.7 to ?6.2‰. In group 1 olivines, as Fa content increases, variation of δ7Li becomes smaller and δ7Li approaches the whole-rock value (2.4‰; Seitz et al., 2012), suggesting nearly complete Li-isotope equilibration. In group 2 and 3 olivines, variation of δ7Li is limited even with a significant range of Fa content. We conclude that Li-isotope compositions of olivine in group 1 chondrules were modified not by an asteroidal process but by an igneous-rim formation process, thus chondrule olivines retained Li-isotope compositions acquired in the protosolar nebula. In olivines of the group 3 chondrule PO-8, we observed a correlation between O and Li isotopes: In relict 16O-rich olivine grains with Δ17O of ??25 to ?20‰, δ7Li ranges from ?23 to ?3‰; in olivine grains with Δ17O?>??20‰, δ7Li is nearly constant (?8?±?4‰). Based on the Li-isotope composition of low-Ca pyroxenes, which formed from melt during the crystallization of host chondrules and igneous rims, the existence of a gaseous reservoir with a δ7Li????11‰ is inferred.
en-copyright=
kn-copyright=

en-aut-name=KunihiroTakuya
en-aut-sei=Kunihiro
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OtaTsutomu
en-aut-sei=Ota
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakamuraEizo
en-aut-sei=Nakamura
en-aut-mei=Eizo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=The Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=2
en-affil=The Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=3
en-affil=The Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University
kn-affil=
en-keyword=Lithium
kn-keyword=Lithium
en-keyword=Oxygen
kn-keyword=Oxygen
en-keyword=Chondrule
kn-keyword=Chondrule
en-keyword=Chondrite
kn-keyword=Chondrite
en-keyword=Asteroid
kn-keyword=Asteroid
en-keyword=Allende
kn-keyword=Allende
en-keyword=Igneous rim
kn-keyword=Igneous rim
en-keyword=SIMS
kn-keyword=SIMS
END

start-ver=1.4
cd-journal=joma
no-vol=79
cd-vols=
no-issue=5
article-no=
start-page=307
end-page=320
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130528
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Biological and genetic diversity of plasmodiophorid-transmitted viruses and their vectors
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= About 20 species of viruses belonging to five genera, Benyvirus, Furovirus, Pecluvirus, Pomovirus and Bymovirus, are known to be transmitted by plasmodiophorids. These viruses have all positive-sense, single-stranded RNA genomes that consist of two to five RNA components. Three species of plasmodiophorids are recognized as vectors: Polymyxa graminis, P. betae, and Spongospora subterranea. The viruses can survive in soil within the long-lived resting spores of the vector. There are biological and genetic variations in both virus and vector species. Many of the viruses are causal agents of important diseases in major crops such as rice, wheat, barley, rye, sugar beet, potato, and groundnut. Control is dependent on the development of resistant cultivars. During the last half century, several virus diseases have rapidly spread worldwide. For six major virus diseases, we address their geographical distribution, diversity, and genetic resistance.
en-copyright=
kn-copyright=

en-aut-name=TamadaTetsuo
en-aut-sei=Tamada
en-aut-mei=Tetsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KondoHideki
en-aut-sei=Kondo
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources (IPSR)Okayama University
kn-affil=

affil-num=2
en-affil=Institute of Plant Science and Resources (IPSR), Okayama University
kn-affil=
en-keyword=Soil-borne viruses
kn-keyword=Soil-borne viruses
en-keyword=Benyvirus
kn-keyword=Benyvirus
en-keyword=Furovirus
kn-keyword=Furovirus
en-keyword=Pecluvirus
kn-keyword=Pecluvirus
en-keyword=Pomovirus
kn-keyword=Pomovirus
en-keyword=Bymovirus
kn-keyword=Bymovirus
en-keyword=Vector transmission
kn-keyword=Vector transmission
en-keyword=Plasmodiophorids
kn-keyword=Plasmodiophorids
en-keyword=Polymyxa
kn-keyword=Polymyxa
en-keyword=Spongospora
kn-keyword=Spongospora
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=5
article-no=
start-page=403
end-page=411
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201910
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Risk Factors for Low Bone Mineral Density Determined in Patients in a General Practice Setting
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Osteoporosis increases the risk of bone fractures. It is diagnosed based on an individual’s bone mineral density (BMD) or a fracture without trauma. BMD is usually measured by the dual energy X-ray absorptiometry (DXA) method. Here we investigated factors for the earliest possible prediction of decreased BMD by examining the relationships between patients’ BMD values and changes in the patients’ physical and laboratory values. We retrospectively reviewed the medical records of 149 patients who visited our department in 2014-2015 for a variety of reasons and underwent an area BMD examination by DXA. We analyzed the relationships between decreasing BMD and the patients’ gender, age, body mass index (BMI), medical background, hemoglobin, electrolytes, and thyroid function. Thirty-nine of the patients were diagnosed with osteoporosis based on their T-scores. An adjusted analysis showed that female gender, aging, and increased serum calcium level were significantly related to decreasing femoral BMD, whereas high BMI was associated with an increase in femoral BMD. Collectively the results indicate that for the early detection of low BMD, it is important for general-practice physicians to consider conducting a BMD checkup when treating female and elderly patients with a low BMI and/or elevated serum calcium level.
en-copyright=
kn-copyright=

en-aut-name=AndoAkemi
en-aut-sei=Ando
en-aut-mei=Akemi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MitsuhashiToshiharu
en-aut-sei=Mitsuhashi
en-aut-mei=Toshiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Honda Mitsugi
en-aut-sei=Honda
en-aut-mei= Mitsugi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HanayamaYoshihisa
en-aut-sei=Hanayama
en-aut-mei=Yoshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HasegawaKou
en-aut-sei=Hasegawa
en-aut-mei=Kou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ObikaMikako
en-aut-sei=Obika
en-aut-mei=Mikako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KataokaHitomi
en-aut-sei=Kataoka
en-aut-mei=Hitomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Division of Radiology, Department of Medical Technology, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=bone mineral density (BMD)
kn-keyword=bone mineral density (BMD)
en-keyword=body mass index (BMI)
kn-keyword=body mass index (BMI)
en-keyword=female gender
kn-keyword=female gender
en-keyword=hypercalcemia
kn-keyword=hypercalcemia
en-keyword=osteoporosis
kn-keyword=osteoporosis
END

start-ver=1.4
cd-journal=joma
no-vol=262
cd-vols=
no-issue=
article-no=
start-page=37
end-page=47
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A novel insect-infecting virga/nege-like virus group and its pervasive endogenization into insect genomes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Insects are the host and vector of diverse viruses including those that infect vertebrates, plants, and fungi. Recent wide-scale transcriptomic analyses have uncovered the existence of a number of novel insect viruses belonging to an alphavirus-like superfamily (virgavirus/negevirus-related lineage). In this study, through an in silico search using publicly available insect transcriptomic data, we found numerous virus-like sequences related to insect virga/nege-like viruses. Phylogenetic analysis showed that these novel viruses and related virus-like sequences fill the major phylogenetic gaps between insect and plant virga/negevirus lineages. Interestingly, one of the phylogenetic clades represents a unique insect-infecting virus group. Its members encode putative coat proteins which contained a conserved domain similar to that usually found in the coat protein of plant viruses in the family Virgaviridae. Furthermore, we discovered endogenous viral elements (EVEs) related to virga/nege-like viruses in the insect genomes, which enhances our understanding on their evolution. Database searches using the sequence of one member from this group revealed the presence of EVEs in a wide range of insect species, suggesting that there has been prevalent infection by this virus group since ancient times. Besides, we present detailed EVE integration profiles of this virus group in some species of the Bombus genus of bee families. A large variation in EVE patterns among Bombus species suggested that while some integration events occurred after the species divergence, others occurred before it. Our analyses support the view that insect and plant virga/nege-related viruses might share common virus origin(s).
en-copyright=
kn-copyright=

en-aut-name=Kondo Hideki
en-aut-sei=Kondo
en-aut-mei= Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=Chiba Sotaro
en-aut-sei=Chiba
en-aut-mei= Sotaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Maruyama Kazuyuki
en-aut-sei=Maruyama
en-aut-mei= Kazuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=Andika Ida Bagus
en-aut-sei=Andika
en-aut-mei= Ida Bagus
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=Suzuki Nobuhiro
en-aut-sei=Suzuki
en-aut-mei= Nobuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources (IPSR), Okayama University
kn-affil=

affil-num=2
en-affil=Asian Satellite Campuses Institute, Nagoya University
kn-affil=

affil-num=3
en-affil=Institute of Plant Science and Resources (IPSR), Okayama University
kn-affil=

affil-num=4
en-affil=Institute of Plant Science and Resources (IPSR), Okayama University
kn-affil=

affil-num=5
en-affil=Institute of Plant Science and Resources (IPSR), Okayama University
kn-affil=
en-keyword=Bumblebee
kn-keyword=Bumblebee
en-keyword=Endogenous viral element
kn-keyword=Endogenous viral element
en-keyword= Evolution
kn-keyword= Evolution
en-keyword=Insect
kn-keyword=Insect
en-keyword= Plant alpha-like virus
kn-keyword= Plant alpha-like virus
en-keyword=Transcriptome shotgun assembly
kn-keyword=Transcriptome shotgun assembly
en-keyword=Whole genome shotgun assembly
kn-keyword=Whole genome shotgun assembly
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=1
article-no=
start-page=3022
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201907
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Origin of ocean island basalts in the West African passive margin without mantle plume involvement
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The geochemical variabilities in intraplate basalts (IB) from the West African passive margin (WAPM) region, have generally been employed to indicate the presence of recycled materials in an associated upwelling mantle plume. However, the absence of time-progressive linear hotspot tracks in WAPM-IB make it difficult to explain their genesis solely by the mantle plume hypothesis. Here, we show that the Sr?Nd?Hf?Pb isotopic variations in basalts from most of the WAPM-IB could have mainly attributed to the derivation from two types of fusible regions of the refertilized subcontinental lithospheric mantle (SCLM) and the sub-lithospheric mantle. The locations and magma genesis of WAPM-IB are strongly related to the distance from the Mesozoic rift axis and the structure of the rifted SCLM. The melting of the source region can possibly be attributed to small-scale mantle convection at the base of the SCLM without the involvement of a mantle plume.
en-copyright=
kn-copyright=

en-aut-name=BelayIyasu Getachew
en-aut-sei=Belay
en-aut-mei=Iyasu Getachew
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TanakaRyoji
en-aut-sei=Tanaka
en-aut-mei=Ryoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KitagawaHiroshi
en-aut-sei=Kitagawa
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KobayashiKatsura
en-aut-sei=Kobayashi
en-aut-mei=Katsura
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakamuraEizo
en-aut-sei=Nakamura
en-aut-mei=Eizo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=2
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=3
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=4
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=5
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=54
cd-vols=
no-issue=
article-no=
start-page=47
end-page=53
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201710
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Characterization of Vibrio cholerae O1 strains that trace the origin of Haitian-like genetic traits
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Vibrio cholerae O1 is the etiological agent of the severe diarrheal disease cholera. The bacterium has recently been causing outbreaks in Haiti with catastrophic effects. Numerous mutations have been reported in V. cholerae O1 strains associated with the Haitian outbreak. These mutations encompass among other the genes encoding virulence factors such as the pilin subunit of the toxin-co-regulated pilus (tcpA), cholera toxin B subunit (ctxB), repeat in toxins (rtxA), and other genes such as the quinolone resistance-determining region (QRDR) of gyrase A (gyrA), rstB of RS element along with the alteration in the number of repeat sequences at the promoter region of ctxAB. Given the numerous genetic changes in those Haitian isolates, we decided to investigate the possible origins of those variations in the Indian subcontinent. Thus, we determined the genetic traits among V. cholerae O1 strains in Delhi, India. A total of 175 strains isolated from cholera patients during 2004 to 2012 were analysed in the present study. Our results showed that all the tested strains carried Haitian type tcpA (tcpACIRS) and variant gyrA indicating their first appearance before 2004 in Delhi. The Haitian variant rtxA and ctxB7 were first detected in Delhi during 2004 and 2006, respectively. Interestingly, not a single strain with the combination of El Tor rtxA and ctxB7 was detected in this study. The Delhi strains carried four heptad repeats (TTTTGAT) in the CT promoter region whereas Haitian strains carried 5 such repeats. Delhi strains did not have any deletion mutations in the rstB like Haitian strains. Overall, our study demonstrates the sequential accumulation of Haitian-like genetic traits among V. cholerae O1 strains in Delhi at different time points prior to the Haitian cholera outbreak.
en-copyright=
kn-copyright=

en-aut-name=GhoshPriyanka
en-aut-sei=Ghosh
en-aut-mei=Priyanka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KumarDhirendra
en-aut-sei=Kumar
en-aut-mei=Dhirendra
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ChowdhuryGoutam
en-aut-sei=Chowdhury
en-aut-mei=Goutam
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SinghPuneeta
en-aut-sei=Singh
en-aut-mei=Puneeta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SamantaProsenjit
en-aut-sei=Samanta
en-aut-mei=Prosenjit
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=DuttaShanta
en-aut-sei=Dutta
en-aut-mei=Shanta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=RamamurthyT.
en-aut-sei=Ramamurthy
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SharmaN. C.
en-aut-sei=Sharma
en-aut-mei=N. C.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SinhaPreety
en-aut-sei=Sinha
en-aut-mei=Preety
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=PrasadYogendra
en-aut-sei=Prasad
en-aut-mei=Yogendra
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=ShinodaSumio
en-aut-sei=Shinoda
en-aut-mei=Sumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=MukhopadhyayAsish K.
en-aut-sei=Mukhopadhyay
en-aut-mei=Asish K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=2
en-affil=Maharishi Valmiki Infectious Diseases Hospital
kn-affil=

affil-num=3
en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=4
en-affil=Maharishi Valmiki Infectious Diseases Hospital
kn-affil=

affil-num=5
en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=6
en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=7
en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=8
en-affil=Maharishi Valmiki Infectious Diseases Hospital
kn-affil=

affil-num=9
en-affil=Department of Zoology, A.N. College
kn-affil=

affil-num=10
en-affil=Department of Animal Science, MJP Rohilkhand University
kn-affil=

affil-num=11
en-affil=Collaborative Research Center of Okayama University for Infectious Diseases at NICED
kn-affil=

affil-num=12
en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases
kn-affil=
en-keyword=Cholera
kn-keyword=Cholera
en-keyword=Vibrio cholerae
kn-keyword=Vibrio cholerae
en-keyword=ctxAB promoter
kn-keyword=ctxAB promoter
en-keyword=ctxB
kn-keyword=ctxB
en-keyword=gyrA
kn-keyword=gyrA
en-keyword=rstB
kn-keyword=rstB
en-keyword=rtxA
kn-keyword=rtxA
en-keyword=tcpA
kn-keyword=tcpA
END

start-ver=1.4
cd-journal=joma
no-vol=25
cd-vols=
no-issue=1
article-no=
start-page=31
end-page=38
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20181227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A new method of terrace analysis to determine precise altitudes of former shoreline
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The study area is situated in Japan Sea side margin of the Shakotan Peninsula, Hokkaido, Japan, where MIS5e Terrace is preserved along the cost. Numbers of tight drilling have done to establish new method for terrace analysis. Buried wave cut terrace and sea cliff (when the MIS5e Terrace was formed) are reconstructed by distribution of the terrace deposits and these bottom of unconformity planes. The precise site and altitude of former shoreline was also obtained. Altitudes of the former shoreline from the 7 sections are almost the same 22 to 27m in height. Previous data of the height of shoreline are obtained from the topographic MIS5e Terrace surface. The altitudes have variation from 30m to 60m. It suggests that the traditional method for the MIS5e terrace analysis had some errors in the study area.
en-copyright=
kn-copyright=

en-aut-name=AmanoHideki
en-aut-sei=Amano
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SuzukiShigeyuki
en-aut-sei=Suzuki
en-aut-mei=Shigeyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SatoMasaru
en-aut-sei=Sato
en-aut-mei=Masaru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YanagidaMakoto
en-aut-sei=Yanagida
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Hanshin Consultants Co., Ltd.,
kn-affil=

affil-num=4
en-affil=Hanshin Consultants Co., Ltd.,
kn-affil=
en-keyword=MIS5e
kn-keyword=MIS5e
en-keyword=marine terrace
kn-keyword=marine terrace
en-keyword=terrace deposits
kn-keyword=terrace deposits
en-keyword=tight drilling
kn-keyword=tight drilling
en-keyword=shoreline
kn-keyword=shoreline
END

start-ver=1.4
cd-journal=joma
no-vol=25
cd-vols=
no-issue=1
article-no=
start-page=7
end-page=17
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20181227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Synoptic climatological analyses on the large day-to-day variation of air temperature around Germany in winter (Relating to the “seasonal feeling” in “Fasnacht”, the festival for driving the winter away)
kn-title=ドイツ付近の冬における日々の大きな気温変動に関する総観気候学的解析（冬の追い出しの行事「ファスナハト」における季節感に関連して）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Synoptic climatological analyses associated with the large day-to-day variation of air temperature around Germany in winter were performed based mainly on the NCEP/NCAR reanalysis data for 2000/2001 to 2010/2011 winters, with an interest in the relationship to the “seasonal feeling” in “Fasnacht”, the festival for driving the winter away. The intermittent appearance of the extremely cold days with rather large day-to-day variation in winter as pointed out by Kato et al. (2017) for around Germany was seen also to the north and to the east of Germany. According to a case study for the 2000/2001 winter, such large daily mean temperature fluctuation was closely related to the intraseasonal variation of the Icelandic low with about one month period, i.e., while the temperature around Germany was relatively higher at the eastward shift phase of the Icelandic low due to the strong warm air advection by the SW-ly wind, the temperature was extremely low there when the Icelandic low was weakened and retreated westward.
en-copyright=
kn-copyright=

en-aut-name=HamakiTatsuya
en-aut-sei=Hamaki
en-aut-mei=Tatsuya
kn-aut-name=濱木達也
kn-aut-sei=濱木
kn-aut-mei=達也
aut-affil-num=1
ORCID=

en-aut-name=KatoKuranoshin
en-aut-sei=Kato
en-aut-mei=Kuranoshin
kn-aut-name=加藤内藏進 
kn-aut-sei=加藤
kn-aut-mei=内藏進 
aut-affil-num=2
ORCID=

en-aut-name=OtaniKazuo
en-aut-sei=Otani
en-aut-mei=Kazuo
kn-aut-name=大谷和男
kn-aut-sei=大谷
kn-aut-mei=和男
aut-affil-num=3
ORCID=

en-aut-name=KatoHaruko
en-aut-sei=Kato
en-aut-mei=Haruko
kn-aut-name=加藤晴子
kn-aut-sei=加藤
kn-aut-mei=晴子
aut-affil-num=4
ORCID=

en-aut-name=MatsumotoKengo
en-aut-sei=Matsumoto
en-aut-mei=Kengo
kn-aut-name=松本健吾
kn-aut-sei=松本
kn-aut-mei=健吾
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Education, Okayama University
kn-affil=岡山大学大学院教育学研究科

affil-num=2
en-affil=Graduate School of Education, Okayama University
kn-affil=岡山大学大学院教育学研究科

affil-num=3
en-affil=TV Setouchi Broadcasting Co., LTD.
kn-affil=テレビせとうち(株)

affil-num=4
en-affil=Faculty of Education, Gifu Shotoku Gakuen University
kn-affil=岐阜聖徳学園大学教育学部

affil-num=5
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
en-keyword=Comparative climatology
kn-keyword=Comparative climatology
en-keyword=Climate around Europe
kn-keyword=Climate around Europe
en-keyword=Synoptic climatology on daily temperature variation in winter around Germany
kn-keyword=Synoptic climatology on daily temperature variation in winter around Germany
en-keyword=seasonal cycle and “seasonal feeling”
kn-keyword=seasonal cycle and “seasonal feeling”
END

start-ver=1.4
cd-journal=joma
no-vol=32
cd-vols=
no-issue=supplment 1
article-no=
start-page=A20
end-page=A28
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140811
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Hospital based surveillance and genetic characterization of rotavirus strains in children (<5 years) with acute gastroenteritis in Kolkata, India, revealed resurgence of G9 and G2 genotypes during 2011-2013
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=INTRODUCTION:　
India accounts for an estimated 457,000-884,000 hospitalizations and 2 million outpatient visits for diarrhea. In spite of the huge burden of rotavirus (RV) disease, RV vaccines have not been introduced in national immunization programme of India. Therefore, continuous surveillance for prevalence and monitoring of the circulating genotypes is needed to assess the disease burden prior to introduction of vaccines in this region.　

METHODS:　
During January 2011 through December 2013, 830 and 1000 stool samples were collected from hospitalized and out-patient department (OPD) patients, respectively, in two hospitals in Kolkata, Eastern India. After primary screening, the G-P typing was done by multiplex semi-nested PCR using type specific primers followed by sequencing. Phylogenetic analysis for the VP7 gene of 25 representative strains was done.　

RESULTS:　
Among hospitalized and OPD patients, 53.4% and 47.5% cases were positive for rotaviruses, respectively. Unlike previous studies where G1 was predominant, in hospitalized cases G9 rotavirus strains were most prevalent (40%), followed by G2 (39.6%) whereas G1 and G12 occurred at 16.4% and 5.6% frequency. In OPD cases, the most prevalent strain was G2 (40.3%), followed by G1, G9 and G12 at 25.5%, 22.8%, 9.3%, respectively. Phylogenetically the G1, G2 and G9 strains from Kolkata did not cluster with corresponding genotypes of Rotarix, RotaTeq and Rotavac (116E) vaccine strains.　

CONCLUSION:　
The study highlights the high prevalence of RV in children with gastroenteritis in Kolkata. The circulating genotypes have changed over the time with predominance of G9 and G2 strains during 2011-2013. The current G2, G9 and G1 Kolkata strains shared low amino acid homologies with current vaccine strains. Although there is substantial evidence for cross protection of vaccines against a variety of strains, still the strain variation should be monitored post vaccine introduction to determine if it has any impact on vaccine effectiveness.
en-copyright=
kn-copyright=

en-aut-name=MullickSatarupa
en-aut-sei=Mullick
en-aut-mei=Satarupa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MandalPaulami
en-aut-sei=Mandal
en-aut-mei=Paulami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Mukti Kant Nayak
en-aut-sei=Mukti Kant Nayak
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=GhoshSouvik
en-aut-sei=Ghosh
en-aut-mei=Souvik
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=DePapiya
en-aut-sei=De
en-aut-mei=Papiya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=RajendranK.
en-aut-sei=Rajendran
en-aut-mei=K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=BhattacharyaMihir K.
en-aut-sei=Bhattacharya
en-aut-mei=Mihir K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MitraUtpala
en-aut-sei=Mitra
en-aut-mei=Utpala
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=RamamurthyThandavarayan
en-aut-sei=Ramamurthy
en-aut-mei=Thandavarayan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KobayashiNobumichi
en-aut-sei=Kobayashi
en-aut-mei=Nobumichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=Chawla-SarkarMamta
en-aut-sei=Chawla-Sarkar
en-aut-mei=Mamta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=2
en-affil=National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=3
en-affil=National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=4
en-affil=Department of Hygiene, Sapporo Medical University School of Medicine
kn-affil=

affil-num=5
en-affil=National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=6
en-affil=National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=7
en-affil=National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=8
en-affil=National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=9
en-affil=National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=10
en-affil=Department of Hygiene, Sapporo Medical University School of Medicine
kn-affil=

affil-num=11
en-affil=National Institute of Cholera and Enteric Diseases
kn-affil=
en-keyword=Diarrhea
kn-keyword=Diarrhea
en-keyword=Rotavirus
kn-keyword=Rotavirus
en-keyword=India
kn-keyword=India
en-keyword=Kolkata
kn-keyword=Kolkata
en-keyword=G9 strains
kn-keyword=G9 strains
en-keyword=G2 strains
kn-keyword=G2 strains
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=
article-no=
start-page=1250
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160809
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Phenotypic and Genetic Heterogeneity in Vibrio cholerae O139 Isolated from Cholera Cases in Delhi, India during 2001-2006
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Incidence of epidemic Vibrio cholerae serogroup O139 has declined in cholera endemic countries. However, sporadic cholera caused by V. cholerae O139 with notable genetic changes is still reported from many regions. In the present study, 42 V. cholerae O139 strains isolated from 2001 to 2006 in Delhi, India, were retrospectively analyzed to understand their phenotype and molecular characteristics. The majority of isolates were resistant to ampicillin, furazolidone and nalidixic acid. Though the integrative conjugative element was detected in all the O139 isolates, the 2004?2006 isolates remained susceptible to co-trimoxazole, chloramphenicol, and streptomycin. Cholera toxin genotype 1 was present in the majority of the O139 isolates while few had type 3 or a novel type 4. In the cholera toxin encoding gene (ctx) restriction fragment length polymorphism, the majority of the isolates harbored three copies of CTX element, of which one was truncated. In this study, the ctx was detected for the first time in the small chromosome of V. cholerae O139 and one isolate harbored 5 copies of CTX element, of which 3 were truncated. The ribotype BII pattern was found in most of the O139 isolates. Three V. cholerae O139 isolated in 2001 had a new ribotype BVIII. Pulsed-field gel electrophoresis analysis revealed clonal variation in 2001 isolates compared to the 2004?2006 isolates. Molecular changes in V. cholerae O139 have to be closely monitored as this information may help in understanding the changing genetic features of this pathogen in relation to the epidemiology of cholera.
en-copyright=
kn-copyright=

en-aut-name=GhoshRaikamal
en-aut-sei=Ghosh
en-aut-mei=Raikamal
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SharmaNaresh C.
en-aut-sei=Sharma
en-aut-mei=Naresh C.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HalderKalpataru
en-aut-sei=Halder
en-aut-mei=Kalpataru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=BhadraRupak K.
en-aut-sei=Bhadra
en-aut-mei=Rupak K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ChowdhuryGoutam
en-aut-sei=Chowdhury
en-aut-mei=Goutam
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=PazhaniGururaja P.
en-aut-sei=Pazhani
en-aut-mei=Gururaja P.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ShinodaSumio
en-aut-sei=Shinoda
en-aut-mei=Sumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MukhopadhyayAsish K.
en-aut-sei=Mukhopadhyay
en-aut-mei=Asish K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NairG. Balakrish
en-aut-sei=Nair
en-aut-mei=G. Balakrish
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=RamamurthyThadavarayan
en-aut-sei=Ramamurthy
en-aut-mei=Thadavarayan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=2
en-affil=Maharishi Valmiki Infectious Diseases Hospital
kn-affil=

affil-num=3
en-affil=Infectious Diseases and Immunology Division, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology
kn-affil=

affil-num=4
en-affil=Infectious Diseases and Immunology Division, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology
kn-affil=

affil-num=5
en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=6
en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=7
en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India, National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=8
en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=9
en-affil=Center for Human Microbial Ecology, Translational Health Science and Technology Institute
kn-affil=

affil-num=10
en-affil=Center for Human Microbial Ecology, Translational Health Science and Technology Institute
kn-affil=
en-keyword=V.cholerae O139
kn-keyword=V.cholerae O139
en-keyword=ribotypes
kn-keyword=ribotypes
en-keyword=CT genotype
kn-keyword=CT genotype
en-keyword=CTX prophage
kn-keyword=CTX prophage
en-keyword=PFGE
kn-keyword=PFGE
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=2
article-no=
start-page=e0005386
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170213
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Comparative genome analysis of VSP-II and SNPs reveals heterogenic variation in contemporary strains of Vibrio cholerae O1 isolated from cholera patients in Kolkata, India
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Cholera is an acute diarrheal disease and a major public health problem in many developing countries in Asia, Africa, and Latin America. Since the Bay of Bengal is considered the epicenter for the seventh cholera pandemic, it is important to understand the genetic dynamism of Vibrio cholerae from Kolkata, as a representative of the Bengal region. We analyzed whole genome sequence data of V. cholerae O1 isolated from cholera patients in Kolkata, India, from 2007 to 2014 and identified the heterogeneous genomic region in these strains. In addition, we carried out a phylogenetic analysis based on the whole genome single nucleotide polymorphisms to determine the genetic lineage of strains in Kolkata. This analysis revealed the heterogeneity of the Vibrio seventh pandemic island (VSP)-II in Kolkata strains. The ctxB genotype was also heterogeneous and was highly related to VSP-II types. In addition, phylogenetic analysis revealed the shifts in predominant strains in Kolkata. Two distinct lineages, 1 and 2, were found between 2007 and 2010. However, the proportion changed markedly in 2010 and lineage 2 strains were predominant thereafter. Lineage 2 can be divided into four sublineages, I, II, III and IV. The results of this study indicate that lineages 1 and 2-I were concurrently prevalent between 2007 and 2009, and lineage 2-III observed in 2010, followed by the predominance of lineage 2-IV in 2011 and continued until 2014. Our findings demonstrate that the epidemic of cholera in Kolkata was caused by several distinct strains that have been constantly changing within the genetic lineages of V. cholerae O1 in recent years.
en-copyright=
kn-copyright=

en-aut-name=ImamuraDaisuke
en-aut-sei=Imamura
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MoritaMasatomo
en-aut-sei=Morita
en-aut-mei=Masatomo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SekizukaTsuyoshi
en-aut-sei=Sekizuka
en-aut-mei=Tsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MizunoTamaki
en-aut-sei=Mizuno
en-aut-mei=Tamaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakemuraTaichiro
en-aut-sei=Takemura
en-aut-mei=Taichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamashiroTetsu
en-aut-sei=Yamashiro
en-aut-mei=Tetsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ChowdhuryGoutam
en-aut-sei=Chowdhury
en-aut-mei=Goutam
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=Pazhani Gururaja P.
en-aut-sei=Pazhani
en-aut-mei= Gururaja P.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MukhopadhyayAsish K.
en-aut-sei=Mukhopadhyay
en-aut-mei=Asish K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=RamamurthyThandavarayan
en-aut-sei=Ramamurthy
en-aut-mei=Thandavarayan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=MiyoshiShin-ichi
en-aut-sei=Miyoshi
en-aut-mei=Shin-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KurodaMakoto
en-aut-sei=Kuroda
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=ShinodaSumio
en-aut-sei=Shinoda
en-aut-mei=Sumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=OhnishiMakoto
en-aut-sei=Ohnishi
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India
kn-affil=

affil-num=2
en-affil=Department of Bacteriology I, National Institute of Infectious Diseases
kn-affil=

affil-num=3
en-affil=Pathogen Genomics Center, National Institute of Infectious Diseases
kn-affil=

affil-num=4
en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India
kn-affil=

affil-num=5
en-affil=Vietnam Research Station, Institute of Tropical Medicine, Nagasaki University
kn-affil=

affil-num=6
en-affil=Vietnam Research Station, Institute of Tropical Medicine, Nagasaki University
kn-affil=

affil-num=7
en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=8
en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=9
en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=10
en-affil=Translational Health Science and Technology Institute
kn-affil=

affil-num=11
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=12
en-affil=Pathogen Genomics Center, National Institute of Infectious Diseases
kn-affil=

affil-num=13
en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India
kn-affil=

affil-num=14
en-affil=Department of Bacteriology I, National Institute of Infectious Diseases
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=235
cd-vols=
no-issue=
article-no=
start-page=76
end-page=88
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180815
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A simple role of coral-algal symbiosis in coral calcification based on multiple geochemical tracers
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Light-enhanced calcification of reef-building corals, which eventually create vast coral reefs, is well known and based on coral-algal symbiosis. Several controversial hypotheses have been proposed as possible mechanisms for connecting symbiont photosynthesis and coral calcification, including pH rise in the internal pool, role of organic matrix secretion, and enzyme activities. Here, based on the skeletal chemical and isotopic compositions of symbiotic and asymbiotic primary polyps of Acropora digitifera corals, we show a simple pH increase in the calcification medium as the predominant contribution of symbionts to calcification of host corals. We used the symbiotic and asymbiotic primary polyps reared for 10?days at four temperatures (27, 29, 31, and 33?°C), five salinities (34, 32, 30, 28, and 26), and four pCO2 levels (<300, 400, 800, and 1000??atm). As a result of analyzing multiple geochemical tracers (U/Ca, Mg/Ca, Sr/Ca, δ18O, δ13C, and δ44Ca), a clear and systematic decrease in skeletal U/Ca ratio (used as a proxy for calcification fluid pH) was observed, indicating a higher pH of the fluid in symbiotic compared to asymbiotic polyps. In contrast, Mg/Ca ratios (used as a tentative proxy for organic matrix secretion) and δ44Ca (used as an indicator of Ca2+ pathway to the fluid) did not differ between symbiotic and asymbiotic polyps. This suggests that organic matrix secretion related to coral calcification is controlled mainly by the coral host itself, and a transmembrane transport of Ca2+ does not vary according to symbiosis relationship. Skeletal δ18O values of both symbiotic and asymbiotic polyps showed offsets between them with identical temperature dependence. Based on a newly proposed model, behavior of δ18O in the present study seems to reflect the rate of CO2 hydration in the calcifying fluid. Since CO2 hydration is promoted by enzyme carbonic anhydrase, the offset of δ18O values between symbiotic and asymbiotic polyps is attributed to the differences of enzyme activity, although the enzyme is functional even in the asymbiotic polyp. Symbiotic δ13C values in the temperature and salinity experiments were higher compared to those in the asymbiotic polyps due to photosynthesis, although photosynthetic δ13C signals in the pCO2 experiment were masked by the dominant δ13C gradient in dissolved inorganic carbon in seawater caused by 13C-depletd CO2 gas addition in the higher pCO2 treatments. Sr/Ca ratios showed a negligible relationship according to variation of temperature, salinity, and pCO2, although it might be attributed to relatively large deviations of replicates of Sr/Ca ratios in the present study. Overall, only the U/Ca ratio showed a significant difference between symbiotic and asymbiotic polyps throughout all experiments, indicating that the critical effect on coral calcification caused by symbiotic algae is the increase of pH of the calcifying fluid by photosynthesis.
en-copyright=
kn-copyright=

en-aut-name=InoueMayuri
en-aut-sei=Inoue
en-aut-mei=Mayuri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakamuraTakashi
en-aut-sei=Nakamura
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TanakaYasuaki
en-aut-sei=Tanaka
en-aut-mei=Yasuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SuzukiAtsushi
en-aut-sei=Suzuki
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YokoyamaYusuke
en-aut-sei=Yokoyama
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KawahataHodaka
en-aut-sei=Kawahata
en-aut-mei=Hodaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SakaiKazuhiko
en-aut-sei=Sakai
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=GussoneNikolaus
en-aut-sei=Gussone
en-aut-mei=Nikolaus
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Division of Earth Science, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Faculty of Science, University of the Ryukyus
kn-affil=

affil-num=3
en-affil=Environmental and Life Sciences, Faculty of Science, Universiti Brunei Darussalam
kn-affil=

affil-num=4
en-affil=Geological Survey of Japan, National Institute of Advanced Industrial Science and Technology
kn-affil=

affil-num=5
en-affil=Sesoko Station, Tropical Biosphere Research Center, University of the Ryukyus
kn-affil=

affil-num=6
en-affil=Atmosphere and Ocean Research Institute, The University of Tokyo
kn-affil=

affil-num=7
en-affil=Sesoko Station, Tropical Biosphere Research Center, University of the Ryukyus
kn-affil=

affil-num=8
en-affil=Institut f?r Mineralogie, Universit?t M?nster
kn-affil=
en-keyword=Coral symbiosis
kn-keyword=Coral symbiosis
en-keyword=calcification
kn-keyword=calcification
en-keyword=pH
kn-keyword=pH
en-keyword=geochemical tracers
kn-keyword=geochemical tracers
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=9
article-no=
start-page=094525
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180928
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Temperature-dependent local structure and superconductivity of BaPd2As2 and SrPd2As2
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The local structures of 122-type paradium arsenides, namely BaPd2As2 and SrPd2As2, are examined by As K-edge extended x-ray absorption fine structure measurements to find a possible correlation between the variation of their superconducting transition temperature and the local structure. The local atomic distances are found to be consistent with average distances measured by diffraction techniques. The temperature dependence of mean square relative displacements reveal that, while BaPd2As2 is characterized by a local As-Pd soft mode, albeit with larger atomic disorder, SrPd2As2 shows anomalous As-Pd correlations with a kink at similar to 160 K due to hardening by raising temperature. We have discussed implications of these results and possible mechanisms of differing superconducting transition temperature in relation with the structural instability.
en-copyright=
kn-copyright=

en-aut-name=TerashimaK.
en-aut-sei=Terashima
en-aut-mei=K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ParisE.
en-aut-sei=Paris
en-aut-mei=E.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SimonelliL.
en-aut-sei=Simonelli
en-aut-mei=L.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=Salas-ColeraE.
en-aut-sei=Salas-Colera
en-aut-mei=E.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=PuriA.
en-aut-sei=Puri
en-aut-mei=A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=WakitaT.
en-aut-sei=Wakita
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YamadaY.
en-aut-sei=Yamada
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NakanoS.
en-aut-sei=Nakano
en-aut-mei=S.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=IdeiH.
en-aut-sei=Idei
en-aut-mei=H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KudoK.
en-aut-sei=Kudo
en-aut-mei=K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=NoharaM.
en-aut-sei=Nohara
en-aut-mei=M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=MuraokaY.
en-aut-sei=Muraoka
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=MizokawaT.
en-aut-sei=Mizokawa
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=YokoyaT.
en-aut-sei=Yokoya
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=SainiN. L.
en-aut-sei=Saini
en-aut-mei=N. L.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

affil-num=1
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=2
en-affil=Dipartimento di Fisica, Universit? di Roma “La Sapienza”
kn-affil=

affil-num=3
en-affil=CELLS - ALBA Synchrotron Radiation Facility
kn-affil=

affil-num=4
en-affil=Spanish CRG BM25 Spline, ESRF - The European Synchrotron
kn-affil=

affil-num=5
en-affil=CRG-LISA, ESRF
kn-affil=

affil-num=6
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=7
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=8
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=9
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=10
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=11
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=12
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=13
en-affil=Department of Applied Physics, Waseda University
kn-affil=

affil-num=14
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=15
en-affil=Dipartimento di Fisica, Universit? di Roma “La Sapienza”
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=4
article-no=
start-page=423
end-page=426
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=201808
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Study Design of a Phase II Clinical Trial to Assess the Efficacy and Safety of Eperisone in Japanese Type 2 Diabetes Patients with Risk and Non-risk Alleles of CDKAL1
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Genetic variation in Cdk5 Regulatory Associated Protein 1-Like 1 (CDKAL1) is associated with the development of type 2 diabetes (T2D). Dysfunction of CDKAL1 impairs the translation of proinsulin, which leads to glucose intolerance. Eperisone, an antispasmodic agent, has been shown to ameliorate glucose intolerance in Cdkal1-deficient mice. We have launched a phase II clinical study to investigate the potential anti-diabetic effect of eperisone in T2D patients carrying risk or non-risk alleles of CDKAL1. The primary endpoint is the change of hemoglobin A1c (HbA1c) levels. We also examined whether the efficacy of eperisone in T2D patients is associated with CDKAL1 activity.
en-copyright=
kn-copyright=

en-aut-name=SakakidaKourin
en-aut-sei=Sakakida
en-aut-mei=Kourin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WeiFan-Yan
en-aut-sei=Wei
en-aut-mei=Fan-Yan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SenokuchiTakafumi
en-aut-sei=Senokuchi
en-aut-mei=Takafumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ShimodaSeiya
en-aut-sei=Shimoda
en-aut-mei=Seiya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KakumaTatsuyuki
en-aut-sei=Kakuma
en-aut-mei=Tatsuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ArakiEiichi
en-aut-sei=Araki
en-aut-mei=Eiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TomizawaKazuhito
en-aut-sei=Tomizawa
en-aut-mei=Kazuhito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=The Eperisone for Diabetes with Impaired tRNA (EDIT) Study Group
en-aut-sei=The Eperisone for Diabetes with Impaired tRNA (EDIT) Study Group
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University
kn-affil=

affil-num=2
en-affil=Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University
kn-affil=

affil-num=3
en-affil=Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University
kn-affil=

affil-num=4
en-affil=Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University
kn-affil=

affil-num=5
en-affil=Biostatics Center, Medical School, Kurume University
kn-affil=

affil-num=6
en-affil=Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University
kn-affil=

affil-num=7
en-affil=Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University
kn-affil=

affil-num=8
en-affil=
kn-affil=
en-keyword=diabetes
kn-keyword=diabetes
en-keyword= insulin secretion
kn-keyword= insulin secretion
en-keyword=single nucleotide polymorphism
kn-keyword=single nucleotide polymorphism
en-keyword=glucose
kn-keyword=glucose
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=275
end-page=282
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=201806
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Analysis of All 34 Exons of the SPINK5 Gene in Japanese Atopic Dermatitis Patients
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is a large multidomain serine protease inhibitor that is expressed in epidermal keratinocytes. Nonsense mutations of the SPINK5 gene, which codes for LEKTI, cause Netherton syndrome, which is characterized by hair abnormality, ichthyosis, and atopy. A single nucleotide polymorphism (SNP) of SPINK5, p.K420E, is reported to be associated with the pathogenesis of atopic dermatitis (AD). We studied all 34 exons of the SPINK5 gene in Japanese 57 AD patients and 50 normal healthy controls. We detected nine nonsynonymous variants, including p.K420E; these variants had already been registered in the SNP database. Among them, p.R654H (n=1) was found as a heterozygous mutation in the AD patients, but not in the control. No new mutation was detected. We next compared the data of the AD patients with data from the Human Genetic Variation Database provided by Kyoto University; a significant difference was found in the frequency of the p.S368N genotype distribution. PolyPhen-2 and SIFT, two algorithms for predicting the functional effects of amino acid substitutions, showed significant scores for p.R654H. Therefore, R654H might be a risk factor for epidermal barrier dysfunction in some Japanese AD patients.
en-copyright=
kn-copyright=

en-aut-name=MorizaneShin
en-aut-sei=Morizane
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OuchidaMamoru
en-aut-sei=Ouchida
en-aut-mei=Mamoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SunagawaKo
en-aut-sei=Sunagawa
en-aut-mei=Ko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SugimotoSaeko
en-aut-sei=Sugimoto
en-aut-mei=Saeko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KobashiMina
en-aut-sei=Kobashi
en-aut-mei=Mina
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SugiharaSatoru
en-aut-sei=Sugihara
en-aut-mei=Satoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NomuraHayato
en-aut-sei=Nomura
en-aut-mei=Hayato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TsujiKazuhide
en-aut-sei=Tsuji
en-aut-mei=Kazuhide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SatoAtsushi
en-aut-sei=Sato
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MiuraYoshihiro
en-aut-sei=Miura
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=HattoriHiroaki
en-aut-sei=Hattori
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=TadaKotaro
en-aut-sei=Tada
en-aut-mei=Kotaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=HuhWook-Kang
en-aut-sei=Huh
en-aut-mei=Wook-Kang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=SenoAkemi
en-aut-sei=Seno
en-aut-mei=Akemi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=IwatsukiKeiji
en-aut-sei=Iwatsuki
en-aut-mei=Keiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

affil-num=1
en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Molecular Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Nishigawara Dermatology Clinic
kn-affil=

affil-num=9
en-affil=Sato Dermatology Clinic
kn-affil=

affil-num=10
en-affil=Miura Dermatology Clinic
kn-affil=

affil-num=11
en-affil=Hattori Dermatology and Allergy Clinic
kn-affil=

affil-num=12
en-affil=Tada Dermatology Clinic
kn-affil=

affil-num=13
en-affil=Dr. Huh's Dermatology Clinic
kn-affil=

affil-num=14
en-affil=Department of Dermatology, Mitoyo General Hospital
kn-affil=

affil-num=15
en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=atopic dermatitis
kn-keyword=atopic dermatitis
en-keyword=SPINK5
kn-keyword=SPINK5
en-keyword=LEKTI
kn-keyword=LEKTI
en-keyword=serine protease inhibitor
kn-keyword=serine protease inhibitor
en-keyword=epidermal barrier dysfunction
kn-keyword=epidermal barrier dysfunction
END

start-ver=1.4
cd-journal=joma
no-vol=95
cd-vols=
no-issue=24
article-no=
start-page=245310
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201701
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Transistor properties of exfoliated single crystals of 2H-Mo(Se1-x Te-x) 2 ( 0 <= x <= 1)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Field-effect transistors (FETs) were fabricated using exfoliated single crystals of Mo(Se1-x Te-x)(2) with an x range of 0 to 1, and the transistor properties fully investigated at 295 K in four-terminal measurement mode. The chemical composition and crystal structure of exfoliated single crystals were identified by energy-dispersive x-ray spectroscopy (EDX), single-crystal x-ray diffraction, and Raman scattering, suggesting the 2H - structure in all Mo(Se1-x Te-x)(2). The lattice constants of a and c increase monotonically with increasing x, indicating the substitution of Se by Te. When x < 0.4 in a FET with a thin single crystal of Mo(Se1-x Te-x)(2), n-channel FET properties were observed, changing to p-channelor ambipolar operation for x > 0.4. In contrast, the polarity of a thick single-crystal Mo(Se1-x Te-x)(2) FET did not change despite an increase in x. The change of polarity in a thin single-crystal FET was well explained by the variation of electronic structure. The absence of such change in the thick single-crystal FET can be reasonably interpreted based on the large bulk conduction due to naturally accumulated electrons. The mu value in the thin single-crystal FET showed a parabolic variation, with a minimum mu at around x = 0.4, which probably originates from the disorder of the single crystal caused by the partial replacement of Se by Te, i.e., a disorder that may be due to ionic size difference of Se and Te.
en-copyright=
kn-copyright=

en-aut-name=UesugiEri
en-aut-sei=Uesugi
en-aut-mei=Eri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MiaoXiao
en-aut-sei=Miao
en-aut-mei=Xiao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OtaHiromi
en-aut-sei=Ota
en-aut-mei=Hiromi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=GotoHidenori
en-aut-sei=Goto
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KubozonoYoshihiro
en-aut-sei=Kubozono
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=2
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=3
en-affil=Advanced Science Research Center, Okayama University
kn-affil=

affil-num=4
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=5
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=95
cd-vols=
no-issue=6
article-no=
start-page=064512
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201702
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Locking of length scales in two-band superconductors
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= A model of a clean two-band s-wave superconductor with cylindrical Fermi surfaces, different Fermi velocities v(1),(2), and a general 2x2 coupling matrix V-alpha beta is used to study the order parameter distribution in vortex lattices. The Eilenberger weak coupling formalism is used to calculate numerically the spatial distributions of the pairing amplitudes Delta(1) and Delta(2) of the two bands for vortices parallel to the Fermi cylinders. For generic values of the interband coupling V-12, it is shown that, independently of the couplings V-alpha beta, of the ratio v(1)/v(2), of the temperature, and the applied field, the length scales of spatial variation of Delta(1) and of Delta(2) are the same within the accuracy of our calculations. The only exception from this single length-scale behavior is found for V-12 << V-11, i.e., for nearly decoupled bands.
en-copyright=
kn-copyright=

en-aut-name=IchiokaMasanori
en-aut-sei=Ichioka
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KoganV. G.
en-aut-sei=Kogan
en-aut-mei=V. G.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SchmalianJ.
en-aut-sei=Schmalian
en-aut-mei=J.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Physics, RIIS, Okayama University
kn-affil=

affil-num=2
en-affil=Ames Laboratory-DOE and Department of Physics and Astronomy, Iowa State University
kn-affil=

affil-num=3
en-affil=Institut f?r Theorie der Kondensierten Materie und Institut f?r Festk?rperphysik, Karlsruher Institut f?r Technologie
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=
article-no=
start-page=12138
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=201607
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A heavy metal P-type ATPase OsHMA4 prevents copper accumulation in rice grain
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Rice is a major source of calories and mineral nutrients for over half the world's human population. However, little is known in rice about the genetic basis of variation in accumulation of copper (Cu), an essential but potentially toxic nutrient. Here we identify OsHMA4 as the likely causal gene of a quantitative trait locus controlling Cu accumulation in rice grain. We provide evidence that OsHMA4 functions to sequester Cu into root vacuoles, limiting Cu accumulation in the grain. The difference in grain Cu accumulation is most likely attributed to a single amino acid substitution that leads to different OsHMA4 transport activity. The allele associated with low grain Cu was found in 67 of the 1,367 rice accessions investigated. Identification of natural allelic variation in OsHMA4 may facilitate the development of rice varieties with grain Cu concentrations tuned to both the concentration of Cu in the soil and dietary needs.
en-copyright=
kn-copyright=

en-aut-name=HuangXin-Yuan
en-aut-sei=Huang
en-aut-mei=Xin-Yuan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=DengFenglin
en-aut-sei=Deng
en-aut-mei=Fenglin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamajiNaoki
en-aut-sei=Yamaji
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=PinsonShannon R.M.
en-aut-sei=Pinson
en-aut-mei=Shannon R.M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=Fujii-KashinoMiho
en-aut-sei=Fujii-Kashino
en-aut-mei=Miho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=DankuJohn
en-aut-sei=Danku
en-aut-mei=John
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=DouglasAlex
en-aut-sei=Douglas
en-aut-mei=Alex
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=GuerinotMary Lou
en-aut-sei=Guerinot
en-aut-mei=Mary Lou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SaltDavid E.
en-aut-sei=Salt
en-aut-mei=David E.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MaJian Feng
en-aut-sei=Ma
en-aut-mei=Jian Feng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Institute of Biological and Environmental Sciences, University of Aberdeen
kn-affil=

affil-num=2
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=3
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=4
en-affil= USDA-ARS Dale Bumpers National Rice Research Center
kn-affil=

affil-num=5
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=6
en-affil=Institute of Biological and Environmental Sciences, University of Aberdeen
kn-affil=

affil-num=7
en-affil=
kn-affil=

affil-num=8
en-affil=Department of Biological Sciences, Dartmouth College
kn-affil=

affil-num=9
en-affil=Institute of Biological and Environmental Sciences, University of Aberdeen
kn-affil=

affil-num=10
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=Genetic variation
kn-keyword=Genetic variation
en-keyword=Natural variation in plants
kn-keyword=Natural variation in plants
en-keyword=Quantitative trait
kn-keyword=Quantitative trait
en-keyword=Rice
kn-keyword=Rice
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=41
article-no=
start-page=e01030-17
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201710
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Chloroplast genome sequences of seven strains of bloom-forming raphidophyte, Heterosigma akashiwo
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= We report here the complete chloroplast genome sequences of seven strains of the bloom-forming raphidophyte Heterosigma akashiwo. These ~160-kb sequences contain 124 protein-, 6 rRNA-, and 34 tRNA-coding sequences. Notable sequence variations were observed among these seven sequenced and two previously characterized strains.
en-copyright=
kn-copyright=

en-aut-name=SeoaneSergio
en-aut-sei=Seoane
en-aut-mei=Sergio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HyodoKiwamu
en-aut-sei=Hyodo
en-aut-mei=Kiwamu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=UekiShoko
en-aut-sei=Ueki
en-aut-mei=Shoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Plant Biology and Ecology, University of the Basque Country (UPV/EHU)
kn-affil=

affil-num=2
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=3
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=23
cd-vols=
no-issue=1
article-no=
start-page=33
end-page=42
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20161227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case study on the cyclone activity around Europe from winter to spring of 2000
kn-title=ヨーロッパの冬から春にかけての 低気圧活動に関する事例解析（2000年を例に）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Although the extratropical cyclone is one of the basic systems that characterize the weather and climate in mid-latitude regions with the large meridional temperature gradient, its activity and characteristics would be greatly influenced by the seasonal transition and regional differences of the mean atmospheric fields such as between Europe and East Asia. Furthermore, detailed knowledge of the daily cyclone activity would help to understand deeply the differences of regional climatology including seasonal cycles among various areas. In such interest, the present study performed a case study on the cyclone activity around Europe from winter to spring of 2000. In winter, intraseasonal variation of the Icelandic Low was dominant. In the stage when such intraseasonal-scale Icelandic Low approached to the northwestern Europe, the several lows passed eastward with a few days interval around the intraseasonal-scale low pressure area or its southern edge where the baroclinicity was relatively strong. It is also noted that their center pressure was rather low (below 980hPa). After April, when the seasonal mean Icelandic low had disappeared, different types of the intra-seasonal-scale cyclones and anticyclones were dominantly observed. In the lower SLP stage of the intraseasonal variation in Europe, the low to the southwest of England in the middle of April was of the equivalent barotropic structure and persisted for about ten days. On the other hand, high pressure area extending from England to the northern coast of Germany also persisted for about half month. The southern half of that high area was also of equivalent barotropic structure with warmer air there.
en-copyright=
kn-copyright=

en-aut-name=KuwanaYusuke
en-aut-sei=Kuwana
en-aut-mei=Yusuke
kn-aut-name=桑名佑典
kn-aut-sei=桑名
kn-aut-mei=佑典
aut-affil-num=1
ORCID=

en-aut-name=KatoKuranoshin
en-aut-sei=Kato
en-aut-mei=Kuranoshin
kn-aut-name=加藤内藏進
kn-aut-sei=加藤
kn-aut-mei=内藏進
aut-affil-num=2
ORCID=

en-aut-name=TakigawaYumi
en-aut-sei=Takigawa
en-aut-mei=Yumi
kn-aut-name=瀧川優実
kn-aut-sei=瀧川
kn-aut-mei=優実
aut-affil-num=3
ORCID=

en-aut-name=KojimaYumi
en-aut-sei=Kojima
en-aut-mei=Yumi
kn-aut-name=小嶋ゆう実
kn-aut-sei=小嶋
kn-aut-mei=ゆう実
aut-affil-num=4
ORCID=

en-aut-name=OtaniKazuo
en-aut-sei=Otani
en-aut-mei=Kazuo
kn-aut-name=大谷和男
kn-aut-sei=大谷
kn-aut-mei=和男
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Faculty of Education, Okayama University
kn-affil=岡山大学教育部 （理科 ）

affil-num=2
en-affil=Graduate School of Education, Okayama University
kn-affil=岡山大学院教育研究科自然系 （理科 ）

affil-num=3
en-affil=Faculty of Education, Okayama University
kn-affil=岡山大学教育部 （理科 ）

affil-num=4
en-affil=Faculty of Education, Okayama University
kn-affil=岡山大学教育部 （理科 ）

affil-num=5
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学院自然科学研究科
en-keyword=cyclone activity around Europe
kn-keyword=cyclone activity around Europe
en-keyword=comparative climatology between Europe and East Asia
kn-keyword=comparative climatology between Europe and East Asia
en-keyword=seasonal cycle
kn-keyword=seasonal cycle
en-keyword=dynamic climatology
kn-keyword=dynamic climatology
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=
article-no=
start-page=157
end-page=166
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170327
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Development of an interdisciplinary class for university students with attention to differences of the climate and “seasonal feeling” in winter : Comparing between those around Germany and the Japan Islands
kn-title=冬の気候と季節感の違いに注目した大学での学際的授業の開発 : ドイツと日本列島付近とを比較して
en-subtitle=
kn-subtitle=
en-abstract=　An interdisciplinary class for university students on the climate in winter around Germany and the traditional event “Fasnacht” for driving winter away was developed, with attention to the variety of seasonal cycles from region to region in middle latitudes. According to the climatological analyses, the “severe winter feeling” around Germany seems to be associated greatly with the intermittent appearance of the extremely cold days as the very large day-to-day variations rather than with the mean lower temperature. In this joint activity, students firstly tried to understand or imagine why the people there can’t help driving the winter away, based on the climate data. After such consideration, each student composed a music work which expresses such “seasonal feeling” about the “Fasnacht” with use of the various small percussion instruments. The students seemed to have an opportunity for realizing the climate in foreign regions and the “seasonal feeling” there, through the composition and performance of the music works in such processes.
kn-abstract=　中高緯度における季節サイクルの多様性や日々の変動に伴う季節の中の幅にも注目して，ドイツ付近での冬の追い出しの行事「ファスナハト」を題材に学際的授業を開発し，大学での教科横断的授業の中での実践結果を検討した。授業では，「ドイツではなぜ冬を追い出さずにはいられないのか」を気候データからイメージして，それを音楽で表現する活動（ファスナハトのオリジナル作品の創作）を行なった。ドイツの冬の厳しさは，平均気温が低いだけでなく，日々の変動が大きい中での極端な低温日の頻出にも特徴づけられていた。音楽での表現活動では，気候データの把握とファスナハトの行事の映像の視聴等により，その行事の存在の意義を考えることが出来た。更に，それらを踏まえた創作と演奏により，日本と比較したドイツ付近の季節の特徴や移り変わりの何に自分が注目しているのかを学生自身が再認識して，気候やそこに住む人々の感じ方を想像する機会となった。
en-copyright=
kn-copyright=

en-aut-name=KatoKuranoshin
en-aut-sei=Kato
en-aut-mei=Kuranoshin
kn-aut-name=加藤内藏進
kn-aut-sei=加藤
kn-aut-mei=内藏進
aut-affil-num=1
ORCID=

en-aut-name=KatoHaruko
en-aut-sei=Kato
en-aut-mei=Haruko
kn-aut-name=加藤晴子
kn-aut-sei=加藤
kn-aut-mei=晴子
aut-affil-num=2
ORCID=

en-aut-name=OtaniKazuo
en-aut-sei=Otani
en-aut-mei=Kazuo
kn-aut-name=大谷和男
kn-aut-sei=大谷
kn-aut-mei=和男
aut-affil-num=3
ORCID=

en-aut-name=HamakiTatsuya
en-aut-sei=Hamaki
en-aut-mei=Tatsuya
kn-aut-name=濱木達也
kn-aut-sei=濱木
kn-aut-mei=達也
aut-affil-num=4
ORCID=

en-aut-name=HagaYuichi
en-aut-sei=Haga
en-aut-mei=Yuichi
kn-aut-name=垪和優一
kn-aut-sei=垪和
kn-aut-mei=優一
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Education, Okayama University
kn-affil=岡山大学大学院教育学研究科理科教育講座

affil-num=2
en-affil=Faculty of Education, Gufu Shotoku Gakuen University
kn-affil=岐阜聖徳学園大学教育学部音楽教室

affil-num=3
en-affil=TV Setouchi Broadcasting Co., LTD
kn-affil=テレビせとうち株式会社

affil-num=4
en-affil=Board of Education, Okayama-city
kn-affil=岡山市教育委員会

affil-num=5
en-affil=Chayamachi Primary School
kn-affil=倉敷市立茶屋町小学校
en-keyword=地学と音楽との連携 (Joint activity of earth science with music)
kn-keyword=地学と音楽との連携 (Joint activity of earth science with music)
en-keyword=学際的気候教育 (Interdisciplinary climate education)
kn-keyword=学際的気候教育 (Interdisciplinary climate education)
en-keyword=季節サイクルと季節感 (Seasonal cycle and “seasonal feeling)
kn-keyword=季節サイクルと季節感 (Seasonal cycle and “seasonal feeling)
en-keyword=ドイツと日本との気候比較 (Comparison of climate between Germany and Japan)
kn-keyword=ドイツと日本との気候比較 (Comparison of climate between Germany and Japan)
en-keyword=ESD
kn-keyword=ESD
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=
article-no=
start-page=27
end-page=32
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=トウガラシ（Capsicum baccatum）における カプサイシノイド含量の変異とその非辛味系統
kn-title=Variations in capsaicinoid contents in the chili pepper (Capsicum baccatum) and its non-pungent accessions
en-subtitle=
kn-subtitle=
en-abstract=　トウガラシ（Capsicum 属）は世界的に重要な香辛料および野菜である．C. baccatum は南米原産のマイナーな栽培種であるが，果色，果形や辛味など果実形質に多様性が認められることから，トウガラシ遺伝資源として注目されている．トウガラシの辛味性についてはC. annuum 種において多くの研究が行われているが，C. baccatum 種においては十分研究されていない．<br>
　本研究では，C. baccatum 36系統について辛味成分カプサイシノイドの含量を調査した．カプサイシノイド含量の幅は0 〜4,258 ? /gDW であった．また果実重と辛味成分含量の間に負の相関が認められた．C. baccatum の辛味は低?中程度であるが，非辛味系統はほとんど認められず，唯一1 系統（‘Kaleidoscope’）が非辛味であった．この非辛味の安定性を調査するために，辛味程度の異なる系統とともに異なる収穫時期におけるカプサイシノイド含量を調査した．<br>
　他のC. baccatum 系統ではカプサイシノイド含量は収穫時期で変化したが，‘Kaleidoscope’ ではいずれの収穫時期でもカプサイシノイドは検出されなかった．本研究で見出された非辛味系統は将来のC. baccatum の育種において有用であろう．
kn-abstract=The chili pepper (Capsicum) is both an important spice and fresh vegetable worldwide. C. baccatum is a lesser known domesticated species that is native to the Andean region. Fruit traits such as color, shape, and pungency markedly vary in this species. C. baccatum has potential as a bioresource for future chili pepper breeding programs. Although extensive studies have been conducted on the pungency of C. annuum, that of C. baccatum has not been examined in as much detail. In the present study, capsaicinoid contents were analyzed in 36 C. baccatum accessions. Capsaicinoid contents ranged between 0 and 4,258 μg/gDW. Furthermore, a negative relationship was observed between capsaicinoid contents and fruit weights. Although the pungency of C. baccatum is regarded as low-mild, very few non-pungent accessions were detected ; only one non-pungent accession (‘Kaleidoscope’) was identified among the C. baccatum accessions examined. In order to validate the stability of non-pungency in the accession, capsaicinoid contents were determined at different harvest dates, along with other accessions with different pungencies. Although capsaicinoid contents in other C. baccatum accessions changed with the picking date, capsaicinoid was not detected in ‘Kaleidoscope’ at any date. The non-pungent accession reported here may be useful for future C. baccatum pepper breeding programs.
en-copyright=
kn-copyright=

en-aut-name=TanakaYoshiyuki
en-aut-sei=Tanaka
en-aut-mei=Yoshiyuki
kn-aut-name=田中義行
kn-aut-sei=田中
kn-aut-mei=義行
aut-affil-num=1
ORCID=

en-aut-name=HaraMotohito
en-aut-sei=Hara
en-aut-mei=Motohito
kn-aut-name=原一仁
kn-aut-sei=原
kn-aut-mei=一仁
aut-affil-num=2
ORCID=

en-aut-name=GotoTanjuro
en-aut-sei=Goto
en-aut-mei=Tanjuro
kn-aut-name=後藤丹十郎
kn-aut-sei=後藤
kn-aut-mei=丹十郎
aut-affil-num=3
ORCID=

en-aut-name=YoshidaYuichi
en-aut-sei=Yoshida
en-aut-mei=Yuichi
kn-aut-name=吉田裕一
kn-aut-sei=吉田
kn-aut-mei=裕一
aut-affil-num=4
ORCID=

en-aut-name=YasubaKen-ichiro
en-aut-sei=Yasuba
en-aut-mei=Ken-ichiro
kn-aut-name=安場健一郎
kn-aut-sei=安場
kn-aut-mei=健一郎
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科

affil-num=2
en-affil=Graduate School of Environmental and life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科

affil-num=3
en-affil=Graduate School of Environmental and life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科

affil-num=4
en-affil=Graduate School of Environmental and life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科

affil-num=5
en-affil=Graduate School of Environmental and life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
en-keyword=Bio-resource
kn-keyword=Bio-resource
en-keyword=Fruit shape
kn-keyword=Fruit shape
END

start-ver=1.4
cd-journal=joma
no-vol=128
cd-vols=
no-issue=3
article-no=
start-page=183
end-page=189
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20161201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Electroencephalography：an old examination tool with a new meaning for childhood epilepsy
kn-title=脳波：小児てんかんにおける古くて新しい検査
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KobayashiKatsuhiro
en-aut-sei=Kobayashi
en-aut-mei=Katsuhiro
kn-aut-name=小林勝弘
kn-aut-sei=小林
kn-aut-mei=勝弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　発達神経病態学
en-keyword=頭皮脳波
kn-keyword=頭皮脳波
en-keyword=点頭てんかん
kn-keyword=点頭てんかん
en-keyword=てんかん外科
kn-keyword=てんかん外科
en-keyword=高周波振動
kn-keyword=高周波振動
en-keyword=時間・周波数分析
kn-keyword=時間・周波数分析
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=
article-no=
start-page=7
end-page=15
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=分子遺伝学的手法を用いたわが国メロン品種の多様性と分類
kn-title=Molecular-based analysis of genetic diversity and classification of Japanese melon breeding lines
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=For the breeding of Japanese netted melon, various types of foreign cultivars have been utilized for improving adaptability, disease and pest resistance, fruit quality and so on. However, little is known about their genetic diversity and relationships, since most cultivars derived from crosses between various horticultural groups. To figure out the genetic structure of Japanese melon, in this study, 57 melon accessions from three horticultural groups were examined using 55 RAPD markers produced by 24 RAPD primers. Genetic diversity of the Japanese netted melon was as high as those of cultivar groups of Groups Cantalupensis and Inodorus, while it was low in Group Conomon irrespective of large variations in fruit traits. Cluster analysis and PCO analysis based on genetic distance showed that Group Conomon was distantly related to other melon accessions. Among the latter, European cantaloupe (nonnetted) and American open-field type (netted) proved to be genetically close, while England glasshouse melon (netted) including ‘Earl’s Favourite’ is distantly related to these two groups and closely related with Group Inodorus. It was therefore suggested that England glasshouse type was established from hybrids between European cantaloupe and Group Inodorus. Japanese netted melon was most closely related with England glasshouse type, irrespective of the fact that various kinds of melon accessions have been crossed to improve adaptability, disease resistance and so on. In contrast, pure line cultivars of the Japanese netted melon bred by pure line selection from ‘Earl's Favourite’ or by crossing ‘Earl’s Favourite’ with ‘British Queen’ were confirmed to be mostly homogenous, and it was difficult to establish RAPD markers to discriminate each cultivar. Group Conomon var. makuwa and var. conomon, which have been cultivated and utilized as different crops, proved to be genetically indistinguishable and were considered to share the same gene pool.
en-copyright=
kn-copyright=

en-aut-name=DungTran Phuong
en-aut-sei=Dung
en-aut-mei=Tran Phuong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TanakaKatsunori
en-aut-sei=Tanaka
en-aut-mei=Katsunori
kn-aut-name=田中克典
kn-aut-sei=田中
kn-aut-mei=克典
aut-affil-num=2
ORCID=

en-aut-name=AkashiYukari
en-aut-sei=Akashi
en-aut-mei=Yukari
kn-aut-name=明石由香利
kn-aut-sei=明石
kn-aut-mei=由香利
aut-affil-num=3
ORCID=

en-aut-name=ThuyDuong Thanh
en-aut-sei=Thuy
en-aut-mei=Duong Thanh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NishidaHidetaka
en-aut-sei=Nishida
en-aut-mei=Hidetaka
kn-aut-name=西田英隆
kn-aut-sei=西田
kn-aut-mei=英隆
aut-affil-num=5
ORCID=

en-aut-name=KatoKenji
en-aut-sei=Kato
en-aut-mei=Kenji
kn-aut-name=加藤鎌司
kn-aut-sei=加藤
kn-aut-mei=鎌司
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学環境生命科学研究科

affil-num=2
en-affil=
kn-affil=弘前大学人文学部

affil-num=3
en-affil=
kn-affil=岡山大学環境生命科学研究科

affil-num=4
en-affil=
kn-affil=岡山大学環境生命科学研究科

affil-num=5
en-affil=
kn-affil=岡山大学環境生命科学研究科

affil-num=6
en-affil=
kn-affil=岡山大学環境生命科学研究科
en-keyword=breeding
kn-keyword=breeding
en-keyword=classification
kn-keyword=classification
en-keyword=genetic diversity
kn-keyword=genetic diversity
en-keyword=melon
kn-keyword=melon
en-keyword=RAPD
kn-keyword=RAPD
END

start-ver=1.4
cd-journal=joma
no-vol=112
cd-vols=
no-issue=39
article-no=
start-page=E5401
end-page=E5410
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150929
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Identification of the VERNALIZATION 4 gene reveals the origin of spring growth habit in ancient wheats from South Asia
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Wheat varieties with a winter growth habit require long exposures to low temperatures (vernalization) to accelerate flowering. Natural variation in four vernalization genes regulating this requirement has favored wheat adaptation to different environments. The first three genes (VRN1?VRN3) have been cloned and characterized before. Here we show that the fourth gene, VRN-D4, originated by the insertion of a ?290-kb region from chromosome arm 5AL into the proximal region of chromosome arm 5DS. The inserted 5AL region includes a copy of VRN-A1 that carries distinctive mutations in its coding and regulatory regions. Three lines of evidence confirmed that this gene is VRN-D4: it cosegregated with VRN-D4 in a high-density mapping population; it was expressed earlier than other VRN1 genes in the absence of vernalization; and induced mutations in this gene resulted in delayed flowering. VRN-D4 was found in most accessions of the ancient subspecies Triticum aestivum ssp. sphaerococcum from South Asia. This subspecies showed a significant reduction of genetic diversity and increased genetic differentiation in the centromeric region of chromosome 5D, suggesting that VRN-D4 likely contributed to local adaptation and was favored by positive selection. Three adjacent SNPs in a regulatory region of the VRN-D4 first intron disrupt the binding of GLYCINE-RICH RNA-BINDING PROTEIN 2 (TaGRP2), a known repressor of VRN1 expression. The same SNPs were identified in VRN-A1 alleles previously associated with reduced vernalization requirement. These alleles can be used to modulate vernalization requirements and to develop wheat varieties better adapted to different or changing environments.
en-copyright=
kn-copyright=

en-aut-name=KippesNestor
en-aut-sei=Kippes
en-aut-mei=Nestor
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=DebernardiJuan M.
en-aut-sei=Debernardi
en-aut-mei=Juan M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Vasquez-GrossHans A.
en-aut-sei=Vasquez-Gross
en-aut-mei=Hans A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AkpinarBala A.
en-aut-sei=Akpinar
en-aut-mei=Bala A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=BudakHikment
en-aut-sei=Budak
en-aut-mei=Hikment
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KatoKenji
en-aut-sei=Kato
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ChaoShiaoman
en-aut-sei=Chao
en-aut-mei=Shiaoman
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=AkhunovEduard
en-aut-sei=Akhunov
en-aut-mei=Eduard
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=DubcovskyJorge
en-aut-sei=Dubcovsky
en-aut-mei=Jorge
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Plant Sciences, University of California

affil-num=2
en-affil=
kn-affil=Department of Plant Sciences, University of California

affil-num=3
en-affil=
kn-affil=Department of Plant Sciences, University of California

affil-num=4
en-affil=
kn-affil=Faculty of Engineering and Natural Sciences, Sabanci University

affil-num=5
en-affil=
kn-affil=Faculty of Engineering and Natural Sciences, Sabanci University

affil-num=6
en-affil=
kn-affil=Graduate School of Environmental and Life Science, Okayama University

affil-num=7
en-affil=
kn-affil=Biosciences Research Lab, US Department of Agriculture?Agricultural Research Service

affil-num=8
en-affil=
kn-affil=Department of Plant Pathology, Kansas State University

affil-num=9
en-affil=
kn-affil=Department of Plant Sciences, University of California
en-keyword=wheat
kn-keyword=wheat
en-keyword=flowering
kn-keyword=flowering
en-keyword=vernalization
kn-keyword=vernalization
en-keyword=VRN1
kn-keyword=VRN1
en-keyword=Triticum aestivum ssp. sphaerococcum
kn-keyword=Triticum aestivum ssp. sphaerococcum
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=3
article-no=
start-page=e91156
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140313
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Genetic Characterization of Hepatitis C Virus in Long-Term RNA Replication Using Li23 Cell Culture Systems
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background　
　
The most distinguishing genetic feature of hepatitis C virus (HCV) is its remarkable diversity and variation. To understand this feature, we previously performed genetic analysis of HCV in the long-term culture of human hepatoma HuH-7-derived HCV RNA-replicating cell lines. On the other hand, we newly established HCV RNA-replicating cell lines using human hepatoma Li23 cells, which were distinct from HuH-7 cells.
　
Methodology/Principal Findings　
　
Li23-derived HCV RNA-replicating cells were cultured for 4 years. We performed genetic analysis of HCVs recovered from these cells at 0, 2, and 4 years in culture. Most analysis was performed in two separate parts: one part covered from the 5′-terminus to NS2, which is mostly nonessential for RNA replication, and the other part covered from NS3 to NS5B, which is essential for RNA replication. Genetic mutations in both regions accumulated in a time-dependent manner, and the mutation rates in the 5′-terminus-NS2 and NS3-NS5B regions were 4.0?9.0×10?3 and 2.7?4.0×10?3 base substitutions/site/year, respectively. These results suggest that the variation in the NS3-NS5B regions is affected by the pressure of RNA replication. Several in-frame deletions (3?105 nucleotides) were detected in the structural regions of HCV RNAs obtained from 2-year or 4-year cultured cells. Phylogenetic tree analyses clearly showed that the genetic diversity of HCV was expanded in a time-dependent manner. The GC content of HCV RNA was significantly increased in a time-dependent manner, as previously observed in HuH-7-derived cell systems. This phenomenon was partially due to the alterations in codon usages for codon optimization in human cells. Furthermore, we demonstrated that these long-term cultured cells were useful as a source for the selection of HCV clones showing resistance to anti-HCV agents.
　
Conclusions/Significance　
　
Long-term cultured HCV RNA-replicating cells are useful for the analysis of evolutionary dynamics and variations of HCV and for drug-resistance analysis.
en-copyright=
kn-copyright=

en-aut-name=KatoNobuyuki
en-aut-sei=Kato
en-aut-mei=Nobuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SejimaHiroe
en-aut-sei=Sejima
en-aut-mei=Hiroe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=UedaYouki
en-aut-sei=Ueda
en-aut-mei=Youki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MoriKyoko
en-aut-sei=Mori
en-aut-mei=Kyoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SatohShinya
en-aut-sei=Satoh
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=DansakoHiromichi
en-aut-sei=Dansako
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=IkedaMasanori
en-aut-sei=Ikeda
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=2
en-affil=
kn-affil=Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=3
en-affil=
kn-affil=Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=4
en-affil=
kn-affil=Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=5
en-affil=
kn-affil=Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=6
en-affil=
kn-affil=Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=7
en-affil=
kn-affil=Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
END

start-ver=1.4
cd-journal=joma
no-vol=21
cd-vols=
no-issue=1
article-no=
start-page=13
end-page=21
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20141227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Aerosol observation at Okayama with Skyradiometer and LIDAR
kn-title=スカイラジオメーターとライダーを用いた岡山上空のエアロゾル観測
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　Aerosol is one of the controlling parameter for the global climate and also effects on local health hazards. The measurement of the aerosol was originally carried out as in-situ sampling and mass weight measurement including chemical analysis. Recently, remote sensing method is applied as satellite remote sensing and surface based remote sensing. Skyradiometer and LIDAR are surface based remote sensing system. Skyradiometer measures solar radiation as direct and scattered solar radiation affected by aerosols. LIDAR emit laser beam upward and it is backscattered by overlying aerosols. The backscattered light is received by a telescope and vertical distributions of the aerosols are obtained. These measurements require atmospheric
radiation physics.
　A Skyradiometer and a LIDAR were operated continuously at Okayama University campus and aerosol parameters were obtained from both of the system. Seasonal variations of the AOT (Aerosol Optical Thickness) and Angstrom parameter (α) are evaluated. During some dust events (e.g. yellow sand and PM2.5), time variations of these parameters were identified from both of the measurement system.
en-copyright=
kn-copyright=

en-aut-name=NagamatsuSinpei
en-aut-sei=Nagamatsu
en-aut-mei=Sinpei
kn-aut-name=永松慎平
kn-aut-sei=永松
kn-aut-mei=慎平
aut-affil-num=1
ORCID=

en-aut-name=EgawaDaiki
en-aut-sei=Egawa
en-aut-mei=Daiki
kn-aut-name=江川大貴
kn-aut-sei=江川
kn-aut-mei=大貴
aut-affil-num=2
ORCID=

en-aut-name=TsukamotoOsamu
en-aut-sei=Tsukamoto
en-aut-mei=Osamu
kn-aut-name=塚本修
kn-aut-sei=塚本
kn-aut-mei=修
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院自然科学研究科

affil-num=2
en-affil=
kn-affil=岡山大学大学院自然科学研究科

affil-num=3
en-affil=
kn-affil=岡山大学大学院自然科学研究科
en-keyword=Aerosol
kn-keyword=Aerosol
en-keyword=Skyradiometer
kn-keyword=Skyradiometer
en-keyword=LIDAR
kn-keyword=LIDAR
en-keyword=Aerosol Optical Thickness (AOT)
kn-keyword=Aerosol Optical Thickness (AOT)
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=2
article-no=
start-page=544
end-page=548
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=201402
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Necessity for Reassessment of Patients with Serogroup 2 Hepatitis C Virus (HCV) and Undetectable Serum HCV RNA
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We encountered a patient positive for anti-hepatitis C virus (HCV) whose serum HCV RNA was undetectable with the Roche AmpliPrep/Cobas TaqMan HCV assay (CAP/CTM) version 1 but showed a high viral load with the Abbott RealTime HCV assay (ART). Discrepancies in the detectability of serum HCV RNA were investigated among 891 consecutive patients who were positive for anti-HCV. Specific nucleotide variations causing the undetectability of HCV RNA were determined and confirmed by synthesizing RNA coding those variations. Serum samples with the discrepancies were also reassessed by CAP/CTM version 2. Among the 891 anti-HCV-positive patients, 4 patients had serum HCV RNA levels that were undetectable by CAP/CTM version 1 despite having levels of > 5 log IU/ml that were detected by ART. All four patients had HCV genotype 2a and high titers of anti-HCV. Sequencing of the HCV 5' noncoding regions revealed 2 common variations, A at nucleotide (nt) 145 and T at nt 151. Synthesized RNAs of the HCV 5' noncoding region with standard (NCR145G151C) and variant nucleotides at nt 145 and nt 151 were quantified with CAP/CTM. RNAs of NCR145G151C and NCR145G151T were quantifiable with CAP/CTM version 1, while those of NCR145A151T and NCR145A151C went undetected. The substitution from G to A at nt 145 specifically conferred this undetectability, while this undetectability was reverted in synthesized HCV RNA with correction of this variation. Reassessment of these samples by CAP/CTM version 2 resulted in similar levels of HCV RNA being detected by ART. We conclude that HCV patients with undetectable HCV RNA by CAP/CTM version 1 should be reassessed for viral quantification.
en-copyright=
kn-copyright=

en-aut-name=MoritouYuki
en-aut-sei=Moritou
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IkedaFusao
en-aut-sei=Ikeda
en-aut-mei=Fusao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakeuchiYasuto
en-aut-sei=Takeuchi
en-aut-mei=Yasuto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SekiHiroyuki
en-aut-sei=Seki
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NanbaShintaro
en-aut-sei=Nanba
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IwasakiYoshiaki
en-aut-sei=Iwasaki
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YamamotoKazuhide
en-aut-sei=Yamamoto
en-aut-mei=Kazuhide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci

affil-num=2
en-affil=
kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci

affil-num=3
en-affil=
kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci

affil-num=4
en-affil=
kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci

affil-num=5
en-affil=
kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci

affil-num=6
en-affil=
kn-affil=Okayama Univ, Hlth Serv Ctr

affil-num=7
en-affil=
kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci
END

start-ver=1.4
cd-journal=joma
no-vol=126
cd-vols=
no-issue=3
article-no=
start-page=199
end-page=201
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20141201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The 2013 Incentive Award of the Okayama Medical Association in Cardiovascular and Pulmonary Research (2013 Sunada Prize)
kn-title=平成25年度岡山医学会賞 胸部・循環研究奨励賞（砂田賞）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=受賞論文: Shinaoka A, Momota R, Shiratsuchi E, Kosaka M, Kumagishi K, Nakahara R, Naito I, Ohtsuka A：Architecture of the subendothelial elastic fibers of small blood vessels and variations in vascular type and size. Microsc Microanal (2013) 19, 406-414.
en-copyright=
kn-copyright=

en-aut-name=ShinaokaAkira
en-aut-sei=Shinaoka
en-aut-mei=Akira
kn-aut-name=品岡玲
kn-aut-sei=品岡
kn-aut-mei=玲
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　人体構成学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20131231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=小児の病院外心停止症例の特徴と転帰についての地域差に関する検討
kn-title=Regional Variation in Survival Following Pediatric Out-of-Hospital Cardiac Arrest
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OkamotoYoshio
en-aut-sei=Okamoto
en-aut-mei=Yoshio
kn-aut-name=岡本吉生
kn-aut-sei=岡本
kn-aut-mei=吉生
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=10
article-no=
start-page=2596
end-page=2603
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=201310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Regional Variation in Survival Following Pediatric Out-of-Hospital Cardiac Arrest
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Although regional variation in outcome after adult out-of-hospital cardiac arrest (OHCA) is known, no clinical studies have assessed this in pediatric OHCA. 

Methods and Results: This nationwide, prospective, population-based observation of the whole of Japan included consecutive OHCA patients with resuscitation attempt from January 2005 through December 2009. Primary outcome was 1-month survival with neurologically favorable outcome. Japan was divided into the following 7 regions as the largest administrative units: Hokkaido-Tohoku, Kanto, Tokai-Hokuriku, Kinki, Chugoku, Shikoku, and Kyushu-Okinawa. The outcome of pediatric OHCA was then compared between the regions. Multiple logistic regression analysis was used to adjust for other factors that were considered to influence the relationship between region and outcome. A total of 8,240 pediatric OHCA patients were registered during the study period. One-month survival with neurologically favorable outcome significantly differed by region: 2.5% (24/967) in Hokkaido-Tohoku (adjusted odds ratio [AOR] 1.65; 95% confidence interval [CI]: 0.94-2.90), 2.9% (47/1614) in Tokai-Hokuriku (AOR, 2.06; 95% CI: 1.28-3.31), 2.1% (26/1239) in Kinki (AOR, 1.45; 95% CI: 0.84-2.51), 3.4% (16/465) in Chugoku (AOR, 3.11; 95% CI: 1.62-6.00), 1.5% (4/259) in Shikoku (AOR, 0.79; 95% CI: 0.26-2.43), and 2.8% (27/974) in Kyushu-Okinawa (AOR, 2.15; 95% CI: 1.24-3.74) referred to Kanto (1.4%, 37/2722). 

Conclusions: According to Japanese nationwide OHCA registry data there are significant regional variations in the outcome of pediatric OHCA.
en-copyright=
kn-copyright=

en-aut-name=OkamotoYoshio
en-aut-sei=Okamoto
en-aut-mei=Yoshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IwamiTaku
en-aut-sei=Iwami
en-aut-mei=Taku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KitamuraTetsuhisa
en-aut-sei=Kitamura
en-aut-mei=Tetsuhisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NittaMasahiko
en-aut-sei=Nitta
en-aut-mei=Masahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HiraideAtsushi
en-aut-sei=Hiraide
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MorishimaTsuneo
en-aut-sei=Morishima
en-aut-mei=Tsuneo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KawamuraTakashi
en-aut-sei=Kawamura
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Univ, Dept Pediat, Grad Sch Med Dent & Pharmaceut Sci

affil-num=2
en-affil=
kn-affil=Kyoto Univ, Hlth Serv

affil-num=3
en-affil=
kn-affil=Osaka Univ, Div Environm Med & Populat Sci, Dept Social & Environm Med, Grad Sch Med

affil-num=4
en-affil=
kn-affil=Osaka Med Coll Hosp, Dept Pediat

affil-num=5
en-affil=
kn-affil=Kinki Univ, Dept Acute Med, Fac Med

affil-num=6
en-affil=
kn-affil=Okayama Univ, Dept Pediat, Grad Sch Med Dent & Pharmaceut Sci

affil-num=7
en-affil=
kn-affil=Kyoto Univ, Hlth Serv
en-keyword=Cardiopulmonary resuscitation
kn-keyword=Cardiopulmonary resuscitation
en-keyword=Children
kn-keyword=Children
en-keyword=Out-of-hospital cardiac arrest
kn-keyword=Out-of-hospital cardiac arrest
en-keyword=Regional variation
kn-keyword=Regional variation
en-keyword=Utstein
kn-keyword=Utstein
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=6
article-no=
start-page=487
end-page=497
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Discovery of High-Confidence Single Nucleotide Polymorphisms from Large-Scale De Novo Analysis of Leaf Transcripts of Aegilops tauschii, A Wild Wheat Progenitor
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Construction of high-resolution genetic maps is important for genetic and genomic research, as well as for molecular breeding. Single nucleotide polymorphisms (SNPs) are the,predominant class of genetic variation and can be used as molecular markers. Aegilops tauschii, the D-genome donor of common wheat, is considered a valuable genetic resource for wheat improvement. Our previous study implied that Ae. tauschii accessions can be genealogically divided into two major lineages. In this study, the transcriptome of two Ae. tauschii accessions from each lineage, lineage 1 (L1) and 2 (L2), was sequenced, yielding 9435 SNPs and 739 insertion/deletion polymorphisms (indels) after de novo assembly of the reads. Based on 36 contig sequences, 31 SNPs and six indels were validated on 20 diverse Ae. tauschii accessions. Because almost all of the SNP markers were polymorphic between L1 and L2, and the D-genome donor of common wheat is presumed to belong to L2, these markers are available for D-genome typing in crosses between common wheat varieties and L1-derived synthetic wheat. Due to the conserved synteny between wheat and barley chromosomes, the high-density expressed sequence tag barley map and the hypothetical gene order in barley can be applied to develop markers on target chromosomal regions in wheat.
en-copyright=
kn-copyright=

en-aut-name=IehisaJulio Cesar Masaru
en-aut-sei=Iehisa
en-aut-mei=Julio Cesar Masaru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShimizuAkifumi
en-aut-sei=Shimizu
en-aut-mei=Akifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SatoKazuhiro
en-aut-sei=Sato
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NasudaShuhei
en-aut-sei=Nasuda
en-aut-mei=Shuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakumiShigeo
en-aut-sei=Takumi
en-aut-mei=Shigeo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Kobe Univ, Grad Sch Agr Sci, Lab Plant Genet

affil-num=2
en-affil=
kn-affil=Univ Shiga Prefecture, Dept Biol Resources Management, Sch Environm Sci

affil-num=3
en-affil=
kn-affil=Okayama Univ, Inst Plant Sci & Resources

affil-num=4
en-affil=
kn-affil=Kyoto Univ, Grad Sch Agr, Lab Plant Genet

affil-num=5
en-affil=
kn-affil=Kobe Univ, Grad Sch Agr Sci, Lab Plant Genet
en-keyword=Aegilops tauschii
kn-keyword=Aegilops tauschii
en-keyword=expression sequence tag
kn-keyword=expression sequence tag
en-keyword=next generation sequencing
kn-keyword=next generation sequencing
en-keyword=single nucleotide polymorphism
kn-keyword=single nucleotide polymorphism
en-keyword=wheat
kn-keyword=wheat
END

start-ver=1.4
cd-journal=joma
no-vol=20
cd-vols=
no-issue=1
article-no=
start-page=7
end-page=11
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20131227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On Periploma mitsuganoense Araki (Bivalvia: Mollusca) from the Miocene Bihoku Group in Niimi City, Okayama Prefecture, southwest Japan ―with special reference to it’s paleogeographic significance―
kn-title=岡山県新見市の中新世備北層群からのPeriploma mitsuganoense Araki (Bivalvia: Mollusca)について　―特にその古地理学的意義―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper, we deal with re-description of Periploma mitsuganoense Araki and it’s morphological
variation and significance of the molluscan fauna of it from the Miocene Bihoku Group in Niimi City,
Okayama Prefecture, Southwest Japan. Moreover, the paleogeographic significance of this species is analyzed.
The obtained results are summarized as follows:
1. The morphological variation of Periploma mitsuganoense Araki has a wide range on the basis of the
analysis of the morphological outline.
2. The occurrence of P. mitsuganoense Araki from the Pectinid fauna is the first record in the West Setouchi
Geological Province.
3. It is presumable that P. mitsuganoense Araki is an endemic species in the First Setouchi Geological
Province from a view point of it’s spatial distribution.
en-copyright=
kn-copyright=

en-aut-name=TaguchciEiji
en-aut-sei=Taguchci
en-aut-mei=Eiji
kn-aut-name=田口栄次
kn-aut-sei=田口
kn-aut-mei=栄次
aut-affil-num=1
ORCID=

en-aut-name=KishimotoShingo
en-aut-sei=Kishimoto
en-aut-mei=Shingo
kn-aut-name=岸本眞五
kn-aut-sei=岸本
kn-aut-mei=眞五
aut-affil-num=2
ORCID=

en-aut-name=SuzukiShigeyuki
en-aut-sei=Suzuki
en-aut-mei=Shigeyuki
kn-aut-name=鈴木茂之
kn-aut-sei=鈴木
kn-aut-mei=茂之
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=

affil-num=3
en-affil=
kn-affil=岡山大学理学部地球科学科
en-keyword=Periploma mitsuganoense Araki
kn-keyword=Periploma mitsuganoense Araki
en-keyword=Mollusca
kn-keyword=Mollusca
en-keyword=Miocene
kn-keyword=Miocene
en-keyword=Bihoku Group
kn-keyword=Bihoku Group
en-keyword=morphological variation
kn-keyword=morphological variation
en-keyword=paleogeographic significance
kn-keyword=paleogeographic significance
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=2
article-no=
start-page=406
end-page=414
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=201304
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Architecture of the Subendothelial Elastic Fibers of Small Blood Vessels and Variations in Vascular Type and Size
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Most blood vessels contain elastin that provides the vessels with the resilience and flexibility necessary to control hemodynamics. Pathophysiological hemodynamic changes affect the remodeling of elastic components, but little is known about their structural properties. The present study was designed to elucidate, in detail, the three-dimensional (3D) architecture of delicate elastic fibers in small vessels, and to reveal their architectural pattern in a rat model. The fine vascular elastic components were observed by a newly developed scanning electron microscopy technique using a formic acid digestion with vascular casts. This method successfully visualized the 3D architecture of elastic fibers in small blood vessels, even arterioles and venules. The subendothelial elastic fibers in such small vessels assemble into a sheet of meshwork running longitudinally, while larger vessels have a higher density of mesh and thicker mesh fibers. The quantitative analysis revealed that arterioles had a wider range of mesh density than venules; the ratio of density to vessel size was higher than that in venules. The new method was useful for evaluating the subendothelial elastic fibers of small vessels and for demonstrating differences in the architecture of different types of vessels.
en-copyright=
kn-copyright=

en-aut-name=ShinaokaAkira
en-aut-sei=Shinaoka
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MomotaRyusuke
en-aut-sei=Momota
en-aut-mei=Ryusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShiratsuchiEri
en-aut-sei=Shiratsuchi
en-aut-mei=Eri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KosakaMitsuko
en-aut-sei=Kosaka
en-aut-mei=Mitsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KumagishiKanae
en-aut-sei=Kumagishi
en-aut-mei=Kanae
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NakaharaRyuichi
en-aut-sei=Nakahara
en-aut-mei=Ryuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NaitoIchiro
en-aut-sei=Naito
en-aut-mei=Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OhtsukaAiji
en-aut-sei=Ohtsuka
en-aut-mei=Aiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Human Morphol

affil-num=2
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Human Morphol

affil-num=3
en-affil=
kn-affil=Hayashikane Sangyo Co Ltd, Div Res & Dev

affil-num=4
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Human Morphol

affil-num=5
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Human Morphol

affil-num=6
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Orthopaed Surg

affil-num=7
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Human Morphol

affil-num=8
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Human Morphol
en-keyword=vascular corrosion casting
kn-keyword=vascular corrosion casting
en-keyword=elastic fiber
kn-keyword=elastic fiber
en-keyword=elastin
kn-keyword=elastin
en-keyword=SEM
kn-keyword=SEM
en-keyword=formic acid digestion
kn-keyword=formic acid digestion
en-keyword=rat
kn-keyword=rat
en-keyword=three-dimensional architecture
kn-keyword=three-dimensional architecture
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=微小血管の内皮下弾性線維構造と血管のタイプとサイズ別におけるその変化
kn-title=Architecture of the Subendothelial Elastic Fibers of Small Blood Vessels and Variations in Vascular Type and Size
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ShinaokaAkira
en-aut-sei=Shinaoka
en-aut-mei=Akira
kn-aut-name=品岡玲
kn-aut-sei=品岡
kn-aut-mei=玲
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=59
cd-vols=
no-issue=3
article-no=
start-page=141
end-page=148
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19810330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Variations of calcium, phosphorus, magnesium, and cadmium contents in anomalous-vertebrae fish induced by cadmium
kn-title=カドミウムによって誘発された脊椎骨異常魚のカルシウム, 燐, マグネシウムおよびカドミウム含有量の変化
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MuramotoS.
en-aut-sei=Muramoto
en-aut-mei=S.
kn-aut-name=村本茂樹
kn-aut-sei=村本
kn-aut-mei=茂樹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=62
cd-vols=
no-issue=4
article-no=
start-page=283
end-page=291
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=199103
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Variation in 14 Elements in Water Hyacinth (Eichhornia crassipes) Due to Salinity at Critical Levels
kn-title=耐塩限界濃度におけるホテイアオイ中14種の元素含有量の変化
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MuramotoShigeki
en-aut-sei=Muramoto
en-aut-mei=Shigeki
kn-aut-name=村本茂樹
kn-aut-sei=村本
kn-aut-mei=茂樹
aut-affil-num=1
ORCID=

en-aut-name=AoyamaIsao
en-aut-sei=Aoyama
en-aut-mei=Isao
kn-aut-name=青山勲
kn-aut-sei=青山
kn-aut-mei=勲
aut-affil-num=2
ORCID=

en-aut-name=OkiYoko
en-aut-sei=Oki
en-aut-mei=Yoko
kn-aut-name=沖陽子
kn-aut-sei=沖
kn-aut-mei=陽子
aut-affil-num=3
ORCID=

en-aut-name=YagiMasakazu
en-aut-sei=Yagi
en-aut-mei=Masakazu
kn-aut-name=八木正一
kn-aut-sei=八木
kn-aut-mei=正一
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=

affil-num=3
en-affil=
kn-affil=

affil-num=4
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=62
cd-vols=
no-issue=1
article-no=
start-page=31
end-page=48
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=198903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Habitats and Morphological Variation of Three Submerged Aquatic Weeds, Egeria, Hydrilla and Elodea.
kn-title=沈水雑草オオカナダモ,クロモ,コカナダモの生育環境及び外部形態の変異性に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OkiYoko
en-aut-sei=Oki
en-aut-mei=Yoko
kn-aut-name=沖陽子
kn-aut-sei=沖
kn-aut-mei=陽子
aut-affil-num=1
ORCID=

en-aut-name=ImanishiKiso
en-aut-sei=Imanishi
en-aut-mei=Kiso
kn-aut-name=今西競
kn-aut-sei=今西
kn-aut-mei=競
aut-affil-num=2
ORCID=

en-aut-name=NakagawaKyojiro
en-aut-sei=Nakagawa
en-aut-mei=Kyojiro
kn-aut-name=中川恭二郎
kn-aut-sei=中川
kn-aut-mei=恭二郎
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=

affil-num=3
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=60
cd-vols=
no-issue=1
article-no=
start-page=13
end-page=24
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=198211
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on classification and inheritance of barley varieties having awnless or shorter-awned lateral spikelets (bozu barley) I. Variation of awn types and classification
kn-title=坊主オオムギの分類と遺伝の研究 第1報 芒型の変異と分類
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TakahashiR.
en-aut-sei=Takahashi
en-aut-mei=R.
kn-aut-name=高橋隆平
kn-aut-sei=高橋
kn-aut-mei=隆平
aut-affil-num=1
ORCID=

en-aut-name=HayashiJ.
en-aut-sei=Hayashi
en-aut-mei=J.
kn-aut-name=林二郎
kn-aut-sei=林
kn-aut-mei=二郎
aut-affil-num=2
ORCID=

en-aut-name=MoriyaI.
en-aut-sei=Moriya
en-aut-mei=I.
kn-aut-name=守屋勇
kn-aut-sei=守屋
kn-aut-mei=勇
aut-affil-num=3
ORCID=

en-aut-name=YasudaS.
en-aut-sei=Yasuda
en-aut-mei=S.
kn-aut-name=安田昭三
kn-aut-sei=安田
kn-aut-mei=昭三
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=

affil-num=3
en-affil=
kn-affil=

affil-num=4
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=2
article-no=
start-page=51
end-page=78
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=197909
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Ecological studies on water nutsedge (Cyperus serotinus Rottb.) III. The intraspecific variations
kn-title=ミズガヤツリの防除に関する生態学的研究 III. 種内変異について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NakagawaK.
en-aut-sei=Nakagawa
en-aut-mei=K.
kn-aut-name=中川恭二郎
kn-aut-sei=中川
kn-aut-mei=恭二郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=2
article-no=
start-page=113
end-page=117
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Pathological diagnosis of urothelial carcinoma
kn-title=尿路上皮癌の病理診断―特に平坦病変について―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YanaiHiroyuki
en-aut-sei=Yanai
en-aut-mei=Hiroyuki
kn-aut-name=柳井広之
kn-aut-sei=柳井
kn-aut-mei=広之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学病院 病理診断科
en-keyword=尿路上皮癌
kn-keyword=尿路上皮癌
en-keyword=尿路上皮異形成
kn-keyword=尿路上皮異形成
en-keyword=尿路上皮内癌
kn-keyword=尿路上皮内癌
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120525
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Distinct repeat motifs at the C-terminal region of CagA of Helicobacter pylori strains isolated from diseased patients and asymptomatic individuals in West Bengal, India
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Infection with Helicobacter pylori strains that express CagA is associated with gastritis, peptic ulcer disease, and gastric adenocarcinoma. The biological function of CagA depends on tyrosine phosphorylation by a cellular kinase. The phosphate acceptor tyrosine moiety is present within the EPIYA motif at the C-terminal region of the protein. This region is highly polymorphic due to variations in the number of EPIYA motifs and the polymorphism found in spacer regions among EPIYA motifs. The aim of this study was to analyze the polymorphism at the C-terminal end of CagA and to evaluate its association with the clinical status of the host in West Bengal, India. 

Results: Seventy-seven H. pylori strains isolated from patients with various clinical statuses were used to characterize the C-ternimal polymorphic region of CagA. Our analysis showed that there is no correlation between the previously described CagA types and various disease outcomes in Indian context. Further analyses of different CagA structures revealed that the repeat units in the spacer sequences within the EPIYA motifs are actually more discrete than the previously proposed models of CagA variants. 

Conclusion: Our analyses suggest that EPIYA motifs as well as the spacer sequence units are present as distinct insertions and deletions, which possibly have arisen from extensive recombination events. Moreover, we have identified several new CagA types, which could not be typed by the existing systems and therefore, we have proposed a new typing system. We hypothesize that a cagA gene encoding higher number EPIYA motifs may perhaps have arisen from cagA genes that encode lesser EPIYA motifs by acquisition of DNA segments through recombination events.
en-copyright=
kn-copyright=

en-aut-name=ChattopadhyaySantanu
en-aut-sei=Chattopadhyay
en-aut-mei=Santanu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=PatraRajashree
en-aut-sei=Patra
en-aut-mei=Rajashree
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ChatterjeeRaghunath
en-aut-sei=Chatterjee
en-aut-mei=Raghunath
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=DeRonita
en-aut-sei=De
en-aut-mei=Ronita
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AlamJawed
en-aut-sei=Alam
en-aut-mei=Jawed
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=RamamurthyT.
en-aut-sei=Ramamurthy
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ChowdhuryAbhijit
en-aut-sei=Chowdhury
en-aut-mei=Abhijit
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NairG. Balakrish
en-aut-sei=Nair
en-aut-mei=G. Balakrish
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=BergDouglas E.
en-aut-sei=Berg
en-aut-mei=Douglas E.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MukhopadhyayAsish K.
en-aut-sei=Mukhopadhyay
en-aut-mei=Asish K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=

affil-num=3
en-affil=
kn-affil=

affil-num=4
en-affil=
kn-affil=

affil-num=5
en-affil=
kn-affil=

affil-num=6
en-affil=
kn-affil=

affil-num=7
en-affil=
kn-affil=Liver Res Ctr, Sch Digest & Liver Dis, Inst Post Grad Med Educ & Res

affil-num=8
en-affil=
kn-affil=

affil-num=9
en-affil=
kn-affil=Washington Univ, Sch Med

affil-num=10
en-affil=
kn-affil=Natl Inst Cholera & Enter Dis, Div Bacteriol
en-keyword=Helicobacter pylori
kn-keyword=Helicobacter pylori
en-keyword=CagA
kn-keyword=CagA
en-keyword=Duodenal ulcer
kn-keyword=Duodenal ulcer
END

start-ver=1.4
cd-journal=joma
no-vol=50
cd-vols=
no-issue=4
article-no=
start-page=1308
end-page=1312
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201204
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Real-Time PCR-Based Mismatch Amplification Mutation Assay for Specific Detection of CS6-Expressing Allelic Variants of Enterotoxigenic Escherichia coli and Its Application in Assessing Diarrheal Cases and Asymptomatic Controls
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Enterotoxigenic Escherichia coli (ETEC) expressing the colonization factor CS6 is widespread in many developing countries, including India. The different allelic variants of CS6, caused by point mutations in its structural genes, cssA and cssB, are designated AIBI, AIIBII, AIIIBI, AIBII, and AIIIBII. A simple, reliable, and specific mismatch amplification mutation assay based on real-time quantitative PCR (MAMA-qPCR) was developed for the first time for the detection of CS6-expressing ETEC, along with the identification of allelic variations. The assay was based on mismatched nucleotide incorporation at the penultimate base at the 3' ends of the reverse primers specific for cssA and cssB and was validated using 38 CS6-expressing ETEC isolates. This strategy was effective in detecting all the alleles containing single-nucleotide polymorphisms. Using MAMA-qPCR, we also tested CS6 allelic variants in 145 ETEC isolates from children with acute diarrhea and asymptomatic infections, with the latter serving as controls. We observed that the AIBI and AIIIBI allelic variants were mostly associated with cases rather than controls, whereas the AIIBII variants were detected mostly in controls. In addition, the AIBI and AIIIBI alleles were frequently associated with ETEC harboring the heat-stable toxin gene (est) alone or with the heat-labile toxin gene (elt), whereas the AIIBII allele was predominant in ETEC isolates harboring the elt gene. This study may help in understanding the association of allelic variants in CS6-expressing ETEC with the clinical features of diarrhea, as well as in ETEC vaccine studies.
en-copyright=
kn-copyright=

en-aut-name=SabuiSubrata
en-aut-sei=Sabui
en-aut-mei=Subrata
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=DuttaSanjucta
en-aut-sei=Dutta
en-aut-mei=Sanjucta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=DebnathAnusuya
en-aut-sei=Debnath
en-aut-mei=Anusuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=GhoshAvishek
en-aut-sei=Ghosh
en-aut-mei=Avishek
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HamabataT.
en-aut-sei=Hamabata
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=RajendranK.
en-aut-sei=Rajendran
en-aut-mei=K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=RamamurthyT.
en-aut-sei=Ramamurthy
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NataroJames P.
en-aut-sei=Nataro
en-aut-mei=James P.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SurDipika
en-aut-sei=Sur
en-aut-mei=Dipika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=LevineMyron M.
en-aut-sei=Levine
en-aut-mei=Myron M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=ChatterjeeNabendu Sekhar
en-aut-sei=Chatterjee
en-aut-mei=Nabendu Sekhar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=
kn-affil=Natl Inst Cholera & Enter Dis

affil-num=2
en-affil=
kn-affil=Natl Inst Cholera & Enter Dis

affil-num=3
en-affil=
kn-affil=Natl Inst Cholera & Enter Dis

affil-num=4
en-affil=
kn-affil=Natl Inst Cholera & Enter Dis

affil-num=5
en-affil=
kn-affil=Natl Ctr Global Hlth & Med

affil-num=6
en-affil=
kn-affil=Natl Inst Cholera & Enter Dis

affil-num=7
en-affil=
kn-affil=Natl Inst Cholera & Enter Dis

affil-num=8
en-affil=
kn-affil=Univ Virginia, Sch Med, Dept Pediat

affil-num=9
en-affil=
kn-affil=Natl Inst Cholera & Enter Dis, Calcutta

affil-num=10
en-affil=
kn-affil=Univ Maryland, Sch Med, Ctr Vaccine Dev

affil-num=11
en-affil=
kn-affil=Natl Inst Cholera & Enter Dis
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=3
article-no=
start-page=111
end-page=121
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1968
dt-pub=19681015
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A study on the variation in the growth and the weight of ear of each of the barnyardgrass (Echinochloa crus-galli BEAUV. var. Kasaharae OHWI) grew in rice plant community in the seeding on unfallowing paddy field
kn-title=水稲不耕起栽培田におけるヒメタイヌビエ(Echinochloa crus-galli BEAUV. var. Kasaharae. Ohwi)の個体別生育量と穂重について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NishiK.
en-aut-sei=Nishi
en-aut-mei=K.
kn-aut-name=西克久
kn-aut-sei=西
kn-aut-mei=克久
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=48
cd-vols=
no-issue=3
article-no=
start-page=107
end-page=115
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=196105
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Pathogenic variability attributed to hybridization in Erysiphe graminis hordei. Studies on variation in pathogenicity. II.
kn-title=オオムギのウドンコ病菌における交雑による病原性の変異　病原性の変異に関する研究II
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HiuraU.
en-aut-sei=Hiura
en-aut-mei=U.
kn-aut-name=日浦運治
kn-aut-sei=日浦
kn-aut-mei=運治
aut-affil-num=1
ORCID=

en-aut-name=HetaH.
en-aut-sei=Heta
en-aut-mei=H.
kn-aut-name=部田英雄
kn-aut-sei=部田
kn-aut-mei=英雄
aut-affil-num=2
ORCID=

en-aut-name=TsushimaT.
en-aut-sei=Tsushima
en-aut-mei=T.
kn-aut-name=津島孝宏
kn-aut-sei=津島
kn-aut-mei=孝宏
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=

affil-num=3
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=48
cd-vols=
no-issue=2
article-no=
start-page=49
end-page=54
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=196102
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Heterothallism in Erysiphe graminis hordei. Studies on variation in pathogenicity. I.
kn-title=オオムギウドンコ病菌のHeterothallism病原性の変異に関する研究　I
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HiuraU.
en-aut-sei=Hiura
en-aut-mei=U.
kn-aut-name=日浦運治
kn-aut-sei=日浦
kn-aut-mei=運治
aut-affil-num=1
ORCID=

en-aut-name=HetaH.
en-aut-sei=Heta
en-aut-mei=H.
kn-aut-name=部田英雄
kn-aut-sei=部田
kn-aut-mei=英雄
aut-affil-num=2
ORCID=

en-aut-name=TsushimaT.
en-aut-sei=Tsushima
en-aut-mei=T.
kn-aut-name=津島孝宏
kn-aut-sei=津島
kn-aut-mei=孝宏
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=

affil-num=3
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=2
article-no=
start-page=63
end-page=76
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=1986
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Genetic Variation of Barley Populations Collected in East Nepal
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KonishiTakeo
en-aut-sei=Konishi
en-aut-mei=Takeo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20121231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=近視進行と眼軸延長の季節変動：近視予防トライアルに参加した日本人児童における評価
kn-title=Seasonal variation in myopia progression and axial elongation: an evaluation of Japanese children participating in a myopia control trial
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HujiwaraMiyuki
en-aut-sei=Hujiwara
en-aut-mei=Miyuki
kn-aut-name=藤原美幸
kn-aut-sei=藤原
kn-aut-mei=美幸
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=1
article-no=
start-page=35
end-page=39
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=An epidemiologically rare case of Vibrio vulnificus infection that occurred in October in an inland city of Japan
kn-title=内陸地津山で発症した季節外れのVibrio vulnificus感染症
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　A 68-year-old man with alcohol addiction, who lived in the suburbs of Tsuyama, an inland city located in northeast Okayama prefecture, was transported to the emergency unit of the Tsuyama Central Hospital in a state of cardiopulmonary arrest (CPA). Despite rigorous systemic investigation and treatment, the patient died 2 hours after arrival. After his death, Vibrio vulnificus was isolated from his blood culture.
　Vibrio vulnificus causes fatal infection in humans, usually only in areas located close to the sea where appropriate temperature and suitable salt concentration for its growth are available. Therefore, its occurrence is epidemiologically restricted ; in Japan, the western coastal areas, especially in summers, are reported to be the high-risk regions. This is a rare case because it occurred in a city approximately 50 kilometers from both the Sea of Japan and the Pacific coast of Okayama, and at the end of October in 2011. Economic development and distribution systems have made it possible to transport various food products from coastal areas or abroad to any place in a short time, such that these infections can potentially develop in areas other than expected. We should be aware of the increasing risk of Vibrio vulnificus infection during any season and at any place, especially in patients with abnormal liver function.
en-copyright=
kn-copyright=

en-aut-name=HagiyaHideharu
en-aut-sei=Hagiya
en-aut-mei=Hideharu
kn-aut-name=萩谷英大
kn-aut-sei=萩谷
kn-aut-mei=英大
aut-affil-num=1
ORCID=

en-aut-name=ShiotaSumiko
en-aut-sei=Shiota
en-aut-mei=Sumiko
kn-aut-name=塩田澄子
kn-aut-sei=塩田
kn-aut-mei=澄子
aut-affil-num=2
ORCID=

en-aut-name=MiyoshiShin-ichi
en-aut-sei=Miyoshi
en-aut-mei=Shin-ichi
kn-aut-name=三好伸一
kn-aut-sei=三好
kn-aut-mei=伸一
aut-affil-num=3
ORCID=

en-aut-name=KuroeYasutoshi
en-aut-sei=Kuroe
en-aut-mei=Yasutoshi
kn-aut-name=黒江泰利
kn-aut-sei=黒江
kn-aut-mei=泰利
aut-affil-num=4
ORCID=

en-aut-name=NojimaHiroyoshi
en-aut-sei=Nojima
en-aut-mei=Hiroyoshi
kn-aut-name=野島宏悦
kn-aut-sei=野島
kn-aut-mei=宏悦
aut-affil-num=5
ORCID=

en-aut-name=OtaniShinkichi
en-aut-sei=Otani
en-aut-mei=Shinkichi
kn-aut-name=大谷晋吉
kn-aut-sei=大谷
kn-aut-mei=晋吉
aut-affil-num=6
ORCID=

en-aut-name=SugiyamaJunichi
en-aut-sei=Sugiyama
en-aut-mei=Junichi
kn-aut-name=杉山淳一
kn-aut-sei=杉山
kn-aut-mei=淳一
aut-affil-num=7
ORCID=

en-aut-name=NaitoHiromichi
en-aut-sei=Naito
en-aut-mei=Hiromichi
kn-aut-name=内藤宏道
kn-aut-sei=内藤
kn-aut-mei=宏道
aut-affil-num=8
ORCID=

en-aut-name=KawanishiSusumu
en-aut-sei=Kawanishi
en-aut-mei=Susumu
kn-aut-name=川西進
kn-aut-sei=川西
kn-aut-mei=進
aut-affil-num=9
ORCID=

en-aut-name=HagiokaShingo
en-aut-sei=Hagioka
en-aut-mei=Shingo
kn-aut-name=萩岡信吾
kn-aut-sei=萩岡
kn-aut-mei=信吾
aut-affil-num=10
ORCID=

en-aut-name=MorimotoNaoki
en-aut-sei=Morimoto
en-aut-mei=Naoki
kn-aut-name=森本直樹
kn-aut-sei=森本
kn-aut-mei=直樹
aut-affil-num=11
ORCID=

affil-num=1
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=2
en-affil=
kn-affil=就実大学薬学部　病原微生物学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　衛生微生物化学

affil-num=4
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=5
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=6
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=7
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=8
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=9
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=10
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=11
en-affil=
kn-affil=津山中央病院　救命救急センター
en-keyword=Vibrio vulnificus
kn-keyword=Vibrio vulnificus
END

start-ver=1.4
cd-journal=joma
no-vol=491
cd-vols=
no-issue=7426
article-no=
start-page=711
end-page=716
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20121129
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A physical, genetic and functional sequence assembly of the barley genome
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Barley (Hordeum vulgare L.) is among the world's earliest domesticated and most important crop plants. It is diploid with a large haploid genome of 5.1 gigabases (Gb). Here we present an integrated and ordered physical, genetic and functional sequence resource that describes the barley gene-space in a structured whole-genome context. We developed a physical map of 4.98 Gb, with more than 3.90 Gb anchored to a high-resolution genetic map. Projecting a deep whole-genome shotgun assembly, complementary DNA and deep RNA sequence data onto this framework supports 79,379 transcript clusters, including 26,159 'high-confidence' genes with homology support from other plant genomes. Abundant alternative splicing, premature termination codons and novel transcriptionally active regions suggest that post-transcriptional processing forms an important regulatory layer. Survey sequences from diverse accessions reveal a landscape of extensive single-nucleotide variation. Our data provide a platform for both genome-assisted research and enabling contemporary crop improvement.
en-copyright=
kn-copyright=

en-aut-name=The International Barley Genome Sequencing Consortium
en-aut-sei=The International Barley Genome Sequencing Consortium
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=6
cd-vols=
no-issue=4
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110425
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Environmental Stress-Dependent Effects of Deletions Encompassing Hsp70Ba on Canalization and Quantitative Trait Asymmetry in Drosophila melanogaster
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Hsp70 genes may influence the expression of wing abnormalities in Drosophila melanogaster but their effects on variability in quantitative characters and developmental instability are unclear. In this study, we focused on one of the six Hsp70 genes, Hsp70Ba, and investigated its effects on within-and among-individual variability in orbital bristle number, sternopleural bristle number, wing size and wing shape under different environmental conditions. To do this, we studied a newly constructed deletion, Df(3R)ED5579, which encompasses Hsp70Ba and nine non-Hsp genes, in the heterozygous condition and another, Hsp70Ba(304), which deletes only Hsp70Ba, in the homozygous condition. We found no significant effect of both deletions on within-individual variation quantified by fluctuating asymmetry (FA) of morphological traits. On the other hand, the Hsp70Ba(304)/Hsp70Ba(304) genotype significantly increased among-individual variation quantified by coefficient of variation (CV) of bristle number and wing size in female, while the Df(3R)ED5579 heterozygote showed no significant effect. The expression level of Hsp70Ba in the deletion heterozygote was 6 to 20 times higher than in control homozygotes, suggesting that the overexpression of Hsp70Ba did not influence developmental stability or canalization significantly. These findings suggest that the absence of expression of Hsp70Ba increases CV of some morphological traits and that HSP70Ba may buffer against environmental perturbations on some quantitative traits.
en-copyright=
kn-copyright=

en-aut-name=TakahashiKazuo H.
en-aut-sei=Takahashi
en-aut-mei=Kazuo H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=DabornPhillip J.
en-aut-sei=Daborn
en-aut-mei=Phillip J.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HoffmannAry A.
en-aut-sei=Hoffmann
en-aut-mei=Ary A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=Takano-ShimizuToshiyuki
en-aut-sei=Takano-Shimizu
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Population Genetics, National Institute of Genetics

affil-num=2
en-affil=
kn-affil=Centre for Environmental Stress and Adaptation Research and Department of Genetics, The University of Melbourne

affil-num=3
en-affil=
kn-affil=Centre for Environmental Stress and Adaptation Research and Department of Genetics, The University of Melbourne

affil-num=4
en-affil=
kn-affil=Department of Population Genetics, National Institute of Genetics
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100916
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of small Hsp genes on developmental stability and microenvironmental canalization
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background:
Progression of development has to be insulated from the damaging impacts of environmental and genetic perturbations to produce highly predictable phenotypes. Molecular chaperones, such as the heat shock proteins (HSPs), are known to buffer various environmental stresses, and are deeply involved in protein homeostasis. These characteristics of HSPs imply that they might affect developmental buffering and canalization.

Results:
We examined the role of nine Hsp genes using the GAL4/UAS-RNAi system on phenotypic variation of various morphological traits in Drosophila melanogaster. The stability of bristle number, wing size and wing shape was characterized through fluctuating asymmetry (FA) and the coefficient of variation (CV), or among-individual variation. Progeny of the GAL4/Hsp-RNAi crosses tended to have reduced trait means for both wing size and wing shape. Transcriptional knockdown of Hsp67Bc and Hsp22 significantly increased FA of bristle number, while knockdown of Hsp67Ba significantly increased FA and among-individual variation of wing shape but only in males. Suppression of Hsp67Bb expression significantly increased among-individual variation of bristle number. The knockdown of gene expression was confirmed for Hsp67Ba, Hsp67Bc, Hsp22, and Hsp67Bb. Correlation between FA and CV or among-individual variation of each trait is weak and not significant except for the case of male wing shape.

Conclusion:
Four small Hsp genes (Hsp22, Hsp67Ba, Hsp67Bb and Hsp67Bc) showed involvement in the processes of morphogenesis and developmental stability. Due to possible different functions in terms of developmental buffering of these small Hsps, phenotypic stability of an organism is probably maintained by multiple mechanisms triggered by different environmental and genetic stresses on different traits. This novel finding may lead to a better understanding of non-Hsp90 molecular mechanisms controlling variability in morphological traits.
en-copyright=
kn-copyright=

en-aut-name=TakahashiKazuo H.
en-aut-sei=Takahashi
en-aut-mei=Kazuo H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=RakoLea
en-aut-sei=Rako
en-aut-mei=Lea
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Takano-ShimizuToshiyuki
en-aut-sei=Takano-Shimizu
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HoffmannAry A.
en-aut-sei=Hoffmann
en-aut-mei=Ary A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=LeeSiu F.
en-aut-sei=Lee
en-aut-mei=Siu F.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Research Core for Interdisciplinary Sciences, Okayama University

affil-num=2
en-affil=
kn-affil=Centre for Environmental Stress and Adaptation Research, Department of Genetics, Bio21 Institute, The University of Melbourne

affil-num=3
en-affil=
kn-affil=Department of Population Genetics, National Institute of Genetics

affil-num=4
en-affil=
kn-affil=Centre for Environmental Stress and Adaptation Research, Department of Genetics, Bio21 Institute, The University of Melbourne

affil-num=5
en-affil=
kn-affil=Centre for Environmental Stress and Adaptation Research, Department of Genetics, Bio21 Institute, The University of Melbourne
END

start-ver=1.4
cd-journal=joma
no-vol=102
cd-vols=
no-issue=4
article-no=
start-page=448
end-page=457
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=201108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Genome-wide deficiency mapping of the regions responsible for temporal canalization of the developmental processes of Drosophila melanogaster
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Developmental processes of organisms are programed to proceed in a finely regulated manner and finish within a certain period of time depending on the ambient environmental conditions. Therefore, variation in the developmental period under controlled genetic and environmental conditions indicates innate instability of the developmental process. In this study, we aimed to determine whether a molecular machinery exists that regulates the canalization of the developmental period and, if so, to test whether the same mechanism also stabilizes a morphological trait. To search for regions that influence the instability of the developmental period, we conducted genome-wide deficiency mapping with 441 isogenic deficiency strains covering 65.5% of the Drosophila melanogaster genome. We found that 11 independent deficiencies significantly increased the instability of the developmental period and 5 of these also significantly increased the fluctuating asymmetry of wing shape although there was no significant correlation between the instabilities of developmental period and wing shape in general. These results suggest that canalization processes of the developmental period and morphological traits are at least partially independent. Our findings emphasize the potential importance of temporal variation in development as an indicator of developmental stability and canalization and provide a novel perspective for understanding the regulation of phenotypic variability.
en-copyright=
kn-copyright=

en-aut-name=TakahashiKazuo H.
en-aut-sei=Takahashi
en-aut-mei=Kazuo H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkadaYasukazu
en-aut-sei=Okada
en-aut-mei=Yasukazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TeramuraKouhei
en-aut-sei=Teramura
en-aut-mei=Kouhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Research Core for Interdisciplinary Sciences, Okayama University

affil-num=2
en-affil=
kn-affil=Graduate School of Environmental Science, Okayama University

affil-num=3
en-affil=
kn-affil=Graduate School of Environmental Science, Okayama University
en-keyword=developmental period
kn-keyword=developmental period
en-keyword=developmental stability
kn-keyword=developmental stability
en-keyword=Drosophila melanogaster
kn-keyword=Drosophila melanogaster
en-keyword=wing shape
kn-keyword=wing shape
END

start-ver=1.4
cd-journal=joma
no-vol=27
cd-vols=
no-issue=1
article-no=
start-page=133
end-page=143
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120101
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Natural genetic variation in fluctuating asymmetry of wing shape in Drosophila melanogaster
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Fluctuating asymmetry (FA), defined as random deviation from perfect symmetry, has been used to assay the inability of individuals to buffer their developmental processes from environmental perturbations (i.e., developmental instability). In this study, we aimed to characterize the natural genetic variation in FA of wing shape in Drosophila melanogaster, collected from across the Japanese archipelago. We quantified wing shapes at whole wing and partial wing component levels and evaluated their mean and FA. We also estimated the heritability of the mean and FA of these traits. We found significant natural genetic variation in all the mean wing traits and in FA of one of the partial wing components. Heritability estimates for mean wing shapes were significant in two and four out of five wing traits in males and females, respectively. On the contrary, heritability estimates for FA were low and not significant. This is a novel study of natural genetic variation in FA of wing shape. Our findings suggest that partial wing components behave as distinct units of selection for FA, and local adaptation of the mechanisms to stabilize developmental processes occur in nature.
en-copyright=
kn-copyright=

en-aut-name=TsujinoMasahiro
en-aut-sei=Tsujino
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakahashiKazuo H.
en-aut-sei=Takahashi
en-aut-mei=Kazuo H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Research Core for Interdisciplinary Sciences, Okayama University

affil-num=2
en-affil=
kn-affil=Research Core for Interdisciplinary Sciences, Okayama University
en-keyword=Animal model
kn-keyword=Animal model
en-keyword=Geometric morphometrics
kn-keyword=Geometric morphometrics
en-keyword=Heritability
kn-keyword=Heritability
en-keyword=Natural genetic variation
kn-keyword=Natural genetic variation
en-keyword=Wing shape
kn-keyword=Wing shape
END

start-ver=1.4
cd-journal=joma
no-vol=28
cd-vols=
no-issue=
article-no=
start-page=59
end-page=62
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201204
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Usefulness of ICR mice as genetic resources
kn-title=ICRマウスの遺伝子資源としての有用性
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=ICR(Yok:ICR)mice were introduced into the National Instltute of Infectious Diseases in 1965,and have been bred and produced there.Two inbred mutant mouse strains,MPS and ICGN,were created using(originated from)Yok:ICR mice in 1986.The MPS and ICGN mouse strains have served as the
animal disease models of mycoplasma infectious disease and congenital nephritic syndrome,respectively.
Genetic variations were detected by the genetic monitoring of Yok:ICR mice using biochemical markers.However, no difference was detected in gene expression profiles between the MPS and ICGN mouse strains.ICR mice may harbor genes that are spontaneously mutated,thereby allowing the creation of
new pathological models through the segregation and/or selection(screening)of mutant genes.
en-copyright=
kn-copyright=

en-aut-name=YamamotoYoshie
en-aut-sei=Yamamoto
en-aut-mei=Yoshie
kn-aut-name=山本美江
kn-aut-sei=山本
kn-aut-mei=美江
aut-affil-num=1
ORCID=

en-aut-name=Uchio-YamadaKozue
en-aut-sei=Uchio-Yamada
en-aut-mei=Kozue
kn-aut-name=内尾-山田こずえ
kn-aut-sei=内尾-山田
kn-aut-mei=こずえ
aut-affil-num=2
ORCID=

en-aut-name=TakanoKaoru
en-aut-sei=Takano
en-aut-mei=Kaoru
kn-aut-name=高野薫
kn-aut-sei=高野
kn-aut-mei=薫
aut-affil-num=3
ORCID=

en-aut-name=OguraAtsuo
en-aut-sei=Ogura
en-aut-mei=Atsuo
kn-aut-name=小倉淳郎
kn-aut-sei=小倉
kn-aut-mei=淳郎
aut-affil-num=4
ORCID=

en-aut-name=AsanoToshihiko
en-aut-sei=Asano
en-aut-mei=Toshihiko
kn-aut-name=浅野敏彦
kn-aut-sei=浅野
kn-aut-mei=敏彦
aut-affil-num=5
ORCID=

en-aut-name=NakagawaMasarou
en-aut-sei=Nakagawa
en-aut-mei=Masarou
kn-aut-name=中川雅郎
kn-aut-sei=中川
kn-aut-mei=雅郎
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=国立感染症研究所

affil-num=2
en-affil=
kn-affil=医薬基盤研究所

affil-num=3
en-affil=
kn-affil=医薬基盤研究所

affil-num=4
en-affil=
kn-affil=理化学研究所

affil-num=5
en-affil=
kn-affil=国立感染症研究所

affil-num=6
en-affil=
kn-affil=国立感染症研究所
END

start-ver=1.4
cd-journal=joma
no-vol=33
cd-vols=
no-issue=
article-no=
start-page=20
end-page=34
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Interdisciplinary Class on the Climate Environment around the Japan Islands in Association with the Seasonal Feeling (with Attention to the Transition Stage from Autumn to Winter)
kn-title=多彩な季節感を育む日本の気候環境に関する学際的授業の取り組み（秋から冬への遷移期に注目して）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The complicated seasonal variations are found in East Asia influenced by the Asian monsoon, resulting in the variety of “seasonal feeling”. For example, although the air temperature around the Japan Islands is still rather higher from November to early December than in the midwinter, the wintertime weather pattern often appears then due to the development of the Siberian high. In the Hokuriku District, the Japan Sea side of the central Japan, the shallow convective rainfall called the “Shi-gu-re” frequently occurs associated with the air mass transformation process over the Japan Sea in the cold air outbreak situation from the continent. It is also well known that the “Shi-gu-re” is often used
for expression of the “seasonal feeling” in the Japanese classical literature. Thus the present study tried to develop an interdisciplinary class on the climate environment around the Japan Islands in association with the “seasonal feeling”, with attention to the transition stage from autumn to winter. The present paper will discuss on the joint activity of meteorology with the Japanese classical literature, the music and the art, for the class at the Faculty of Education, Okayama University, and that at the Okayama-Ichinomiya High School.
en-copyright=
kn-copyright=

en-aut-name=KatoKuranoshin
en-aut-sei=Kato
en-aut-mei=Kuranoshin
kn-aut-name=加藤内藏進
kn-aut-sei=加藤
kn-aut-mei=内藏進
aut-affil-num=1
ORCID=

en-aut-name=SatoSari
en-aut-sei=Sato
en-aut-mei=Sari
kn-aut-name=佐藤紗里
kn-aut-sei=佐藤
kn-aut-mei=紗里
aut-affil-num=2
ORCID=

en-aut-name=KatoHaruko
en-aut-sei=Kato
en-aut-mei=Haruko
kn-aut-name=加藤晴子
kn-aut-sei=加藤
kn-aut-mei=晴子
aut-affil-num=3
ORCID=

en-aut-name=AkagiRikako
en-aut-sei=Akagi
en-aut-mei=Rikako
kn-aut-name=赤木里香子
kn-aut-sei=赤木
kn-aut-mei=里香子
aut-affil-num=4
ORCID=

en-aut-name=SueishiNoriko
en-aut-sei=Sueishi
en-aut-mei=Noriko
kn-aut-name=末石範子
kn-aut-sei=末石
kn-aut-mei=範子
aut-affil-num=5
ORCID=

en-aut-name=MoriTaizo
en-aut-sei=Mori
en-aut-mei=Taizo
kn-aut-name=森泰三
kn-aut-sei=森
kn-aut-mei=泰三
aut-affil-num=6
ORCID=

en-aut-name=IrieIzumi
en-aut-sei=Irie
en-aut-mei=Izumi
kn-aut-name=入江泉
kn-aut-sei=入江
kn-aut-mei=泉
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院教育学研究科自然教育学系（理科）

affil-num=2
en-affil=
kn-affil=岡山大学教育学部（理科）

affil-num=3
en-affil=
kn-affil=岐阜聖徳学園大学教育学部音楽教室

affil-num=4
en-affil=
kn-affil=岡山大学大学院教育学研究科芸術教育学系（美術）

affil-num=5
en-affil=
kn-affil=岡山県立岡山一宮高等学校（国語）

affil-num=6
en-affil=
kn-affil=岡山県立岡山一宮高等学校（地理）

affil-num=7
en-affil=
kn-affil=岡山大学大学院教育学研究科自然教育学系（理科）
en-keyword=Climate Environment around Japan
kn-keyword=Climate Environment around Japan
en-keyword=“Seasonal Feeling”
kn-keyword=“Seasonal Feeling”
en-keyword=Joint Activity of Meteorology with Culture
kn-keyword=Joint Activity of Meteorology with Culture
en-keyword=Transition from Autumn to Winter
kn-keyword=Transition from Autumn to Winter
END

start-ver=1.4
cd-journal=joma
no-vol=33
cd-vols=
no-issue=
article-no=
start-page=13
end-page=19
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Areal distribution of water-insoluble particles in snow covers of the central mountainous area, Japan
kn-title=中部山岳地域における積雪中の非溶解性微粒子の地域分布
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The vertical snow samples collected from 6 locations (Iou-zen: 800m A.M.S.L; the nearest site
from the Sea of Japan, Kongoudou-zan: 1300m, Nishi-Hodaka-Dake: 2200m; the Northern Japan Alps,
Hachimori-yama: 2100m, Kiriga-mine: 2000m, Yatsuga-take: 2200m; the most inlying site) in the central mountainous area, Japan, during early spring season 2004, were analyzed for size-separated concentrations of water-insoluble particles in snow layers to investigation of long-range transportation of chemical substances from the Asian continent to high mountainous areas in Japan.
Most of particles are less than 30 μm in diameter, the greater part of particles observed at the 6 locations were considered to be transported from the Asian continent sources as Asian dust (KOSA). The variation patterns of the vertical profiles of particle concentrations in snow layers were corresponding among each
location. The concentrations of particles with less than 30 μm was gradually increased with increasing distance from the Sea of Japan to the Japan Alps, although, sharply-decreased at 3 sites located the monsoon-leeward of the Japan Alps, suggesting that the particles transported with monsoon were gradually removed from air and deposited in snow cover when the air parcel pass through the Japan Alps.
en-copyright=
kn-copyright=

en-aut-name=ToyamaKazuhiro
en-aut-sei=Toyama
en-aut-mei=Kazuhiro
kn-aut-name=遠山和大
kn-aut-sei=遠山
kn-aut-mei=和大
aut-affil-num=1
ORCID=

en-aut-name=MatsumotoEna
en-aut-sei=Matsumoto
en-aut-mei=Ena
kn-aut-name=松本絵菜
kn-aut-sei=松本
kn-aut-mei=絵菜
aut-affil-num=2
ORCID=

en-aut-name=KawadaKunio
en-aut-sei=Kawada
en-aut-mei=Kunio
kn-aut-name=川田邦夫
kn-aut-sei=川田
kn-aut-mei=邦夫
aut-affil-num=3
ORCID=

en-aut-name=SatakeHiroshi
en-aut-sei=Satake
en-aut-mei=Hiroshi
kn-aut-name=佐竹洋
kn-aut-sei=佐竹
kn-aut-mei=洋
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学学務部

affil-num=2
en-affil=
kn-affil=富山大学理学部

affil-num=3
en-affil=
kn-affil=富山大学極東地域研究センター

affil-num=4
en-affil=
kn-affil=富山大学理工学研究部
en-keyword=snow
kn-keyword=snow
en-keyword=mountainous area
kn-keyword=mountainous area
en-keyword=particle
kn-keyword=particle
en-keyword=KOSA
kn-keyword=KOSA
en-keyword=long-range transportation
kn-keyword=long-range transportation
END

start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=
article-no=
start-page=1
end-page=13
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120319
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Development of a Study Plan on Investigating the Long-term Variation of the Baiu Precipitation during the 20th Century with Attention to Appearance of the Heavy Rainfall Days at Nagasaki in the Northwestern Part of Kyushu
kn-title=顕著な大雨日の出現状況に注目した20 世紀の梅雨降水変動に関する探究的授業の開発（九州の長崎を例に）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=梅雨降水量の多い西日本の長崎を例に，20世紀の梅雨降水変動に関する探究的授業の開発を行った。本学習プランは，高校の『地学基礎』，『地学』，『地理』をも念頭に置いたものであるが，岡山大学教育学部の「生活科内容研究A」の1コマ分を使って研究授業を行い，その結果を分析した。気候学的に梅雨が明ける7月後半頃には『無降水日』も多いが，その時期にも主に梅雨前線活動に関連した『顕著な大雨日』がしばしば出現する。授業では，そのような点を探究的に見出すことを目標とし，7月後半頃の日々の大雨日及び無降水日の出現状況やそれらの梅雨最盛期との違い，7月後半頃の顕著な大雨日における気圧配置の特徴などを，6〜7月の日々の降水量データ表などに基づき読み取る作業・考察を学習活動の中心に据えた。本稿では，取り扱った現象の特徴，授業の概要，分析結果などについて報告する。
en-copyright=
kn-copyright=

en-aut-name=KurataMiki
en-aut-sei=Kurata
en-aut-mei=Miki
kn-aut-name=蔵田美希
kn-aut-sei=蔵田
kn-aut-mei=美希
aut-affil-num=1
ORCID=

en-aut-name=KatoKuranoshin
en-aut-sei=Kato
en-aut-mei=Kuranoshin
kn-aut-name=加藤内藏進
kn-aut-sei=加藤
kn-aut-mei=内藏進
aut-affil-num=2
ORCID=

en-aut-name=OtaniKazuo
en-aut-sei=Otani
en-aut-mei=Kazuo
kn-aut-name=大谷和男
kn-aut-sei=大谷
kn-aut-mei=和男
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学教育学部理科教育専修

affil-num=2
en-affil=
kn-affil=岡山大学大学院教育学研究科自然教育学系理科教育講座

affil-num=3
en-affil=
kn-affil=岡山大学大学院自然科学研究科先端基礎科学専攻
en-keyword=『日本の天気』
kn-keyword=『日本の天気』
en-keyword=気象教育
kn-keyword=気象教育
en-keyword=梅雨と豪雨の気候学
kn-keyword=梅雨と豪雨の気候学
en-keyword=20世紀の気候変動
kn-keyword=20世紀の気候変動
en-keyword=探究的気象授業の開発
kn-keyword=探究的気象授業の開発
END

start-ver=1.4
cd-journal=joma
no-vol=54
cd-vols=
no-issue=1
article-no=
start-page=97
end-page=131
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=HOMOGENIZATION OF NON-LINEAR VARIATIONAL PROBLEMS WITH THIN INCLUSIONS
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We are concerned in this work with the asymptotic behavior of an assemblage whose components are a thin inclusion with higher rigidity modulus included into an elastic body. We aim at finding the approximating energy functional of the above structure in a Γ-convergence framework, and making use also of the subadditive theorem and the blow-up method.
en-copyright=
kn-copyright=

en-aut-name=MoussaAbdelaziz A?t
en-aut-sei=Moussa
en-aut-mei=Abdelaziz A?t
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=Zla?jiLoubna
en-aut-sei=Zla?ji
en-aut-mei=Loubna
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Mathematics and Informatics Faculty of Science, Mohammed Premier University

affil-num=2
en-affil=
kn-affil=Department of Mathematics and Informatics, Faculty of Science, Mohammed Premier University
en-keyword=blow-up
kn-keyword=blow-up
en-keyword=Γ-convergence
kn-keyword=Γ-convergence
en-keyword=subadditive theorem
kn-keyword=subadditive theorem
END

start-ver=1.4
cd-journal=joma
no-vol=40
cd-vols=
no-issue=9
article-no=
start-page=1941
end-page=1949
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1928
dt-pub=19280930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Study on the bile pigment originating from hemogrobin
kn-title=肝臟機能ニ關スル研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=I made some experiments on the bile pigment formed at the destruction of the hemogrobin. Method. 1-2% O-Hb Ringer's solution or 1-2% CO-Hb Ringer's solution were perfused through the liver of toads (Bufo japonicos), and then the bile. pigment in the bile duct was measured by the absorption band of the ultraviolet ray, by the absorption band of the visible ray and by the variation of colour. Summary. 1) When O-Hb Ringer's solution was perfused through the liver the bile pigment was elimineted in the bile duct. It is just as the normal bile pigment in colour, in the absorption band of the ultraviolet ray and in the absorption band of the visible ray. 2) The elimination of the bile pigment from the liver is influenced by the poisoning with cyanic acid, i.e. it ceases entirely. 3) If CO-Hb Ringer's solution is perfused through the liver bile pigment is not eliminated.
en-copyright=
kn-copyright=

en-aut-name=NisimaruYasuyosi
en-aut-sei=Nisimaru
en-aut-mei=Yasuyosi
kn-aut-name=西丸和義
kn-aut-sei=西丸
kn-aut-mei=和義
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學生理學教室
END

start-ver=1.4
cd-journal=joma
no-vol=36
cd-vols=
no-issue=1
article-no=
start-page=17
end-page=28
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2001
dt-pub=200112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Application of Dead Beat Control method to the Water Level Control of Small-scale Hydroelectric Power Plant
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Small Scale Hydroelectric Power Generation is made using the water drop caused by the gradient difference between that of the river and that of the penstock. The water flow in this system apt to vary with time. Especially, at the time of the flood or that of the dry, the flow in the water stream varies largely. To realize the stable generation, it is necessary to maintain the water level in the head tank located in the mid way in the stream channel at a constant level. In this paper, variation of water level is forecasted using two-tank model for the penstock and the head tank and the water level control algorithm is proposed by deadbeat control. The effectiveness of the algorithm is evaluated beforehand using the simulation program of the water environment for the hydroelectric generation system.
en-copyright=
kn-copyright=

en-aut-name=EndoShinichiro
en-aut-sei=Endo
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KonishiMasami
en-aut-sei=Konishi
en-aut-mei=Masami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Dept. Electronic Control Engineering Gifu National College of Technology

affil-num=2
en-affil=
kn-affil=Dept. Electrical and Electronic Engineering Okayama Univerisity
END

start-ver=1.4
cd-journal=joma
no-vol=40
cd-vols=
no-issue=5
article-no=
start-page=927
end-page=953
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1928
dt-pub=19280531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Myeloarchitektonische Felder des menschlichen Stirnlappens
kn-title=日本人前頭葉皮質ノ髓鞘構成學的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Aus den Untersuchungen von 5 mittelj?hrigen Japaner-Gehirnen ergibt sich folgendes. 1. Am menschlichen Stirnlappen lassen sich 16 myeloarchitektonische Felder unter-scheiden. (Abb. 3. a und b, Abb. 4, 5, 6, 7.). I. Die Regio frontalis. A) Die Subregio frontalis posterior. 1. Die Area frontalis superior posterior. (Fsp). 2. Die Area frontalis superior media. (Fsm). 3. Die Area frontalis media posterior. (Fmp). 4. Die Area frontalis intermedia. (Fim). 5. Die Area frontalis inferior. (Fi). 6. Die Area frontoorbitalis. (Fio). B) Die Subregio frontalis media. 7. Die Area frontalis superior anterior. (Fsa). 8. Die Area frontalis media anterior. (Fma). 9. Die Area frontopolaris. (Fp). C) Die Subregio frontalis anterior. 10. Die Area praefrontalis prima (Fpr 1). 11. Die Area praefrontalis secunda (Fpr 2). 12. Die Area praefrontalis tertia. (Fpr 3). 13. Die Area praefrontalis quarta. (Fpr 4). D) Die Subregio frontolimbica. 14. Die Area frontolimbica polaris, anterior, media und posterior. (FL). II. Die Regio limbica. 15. Die Area limbica anterior. (La 1, La 2, La 3). 16. Die Area parolfactoria. (P1, P2a, P2b, P2c.). Als Hauptunterschiedsmerkmale sind dabei die Horizontalfasern, insbesondere die beiden Baillargerschen Streifen ausgew?hlt, die die region?re Variation sowie den Differenzierungsgrad irgend eines Rindenbezirks am deutlichsten zeigen m?ssen. 2. Im Stirnhirn ist der kaudale, obere Teil (Subregio frontalis posterior) der h?chstdifferenzierte. Dort sind alle Markscheidenelemente, n?mlich Horizontal-, Radi?r- und Schr?gfasern an Zahl sehr reichhaltig, die dann nach Allocortex Vogts hin immer Schw?cher werden. 3. Die Entwicklungsstufe eines Feldes Kennzeichnet sich d?rch den Bau der Furchenwand. W?hrend die Areae an tiefen Furchen wie Fp oder Fi ?berall ganz gleichartig aufgebaut sind, also da betreffs der Struktur zwischen Kuppe und Tal sich kein Unterschied aufweist, ist die eigentliche Rindenformation eines schwachentwickelten Feldes wie Subregio frontalis anterior an Ausdehnung so sehr kurz, dass sie sich ausschliesslich auf der Windungskuppe erstreckt. 4. Dass die Rindenfeldergrenzen sich nicht immer mit den nat?rlichen Furchen decken k?nnen, ist richtig. Es ist doch auch nicht richtig, wenn man mit Vogt sagen Will, dass ?berhaupt keine Beziehung zwischen den beiden bestehe; denn meine Untersuchung kann zeigen, dass die ontogenetisch alte, relativ konstant vorkommende Furche manchmal irgend einen Einfluss ?ber den Markscheidenbau aus?ben kann. 5. Die ganze Oberfl?che meiner Regio frontalis und Regio limbica (anterior) betr?gt ungef?hr 284 cm2, wovon 134 cm2 auf die freie Oberfl?che, der Rest (150 cm2) ins Furchental f?llt. So kann man leicht einsehen, dass die nur auf der freien Oberfl?che bezeichnete Hirnkarte nicht hinreicht, um die wahre Gr?sse einzelner Area daraus beurteilen zuzulassen; neben der ?blichen Hirnkarte muss also noch eine andere gesucht werden, wie ich in der Abb. 9 dargestellt habe. 6. Individuell ?ndern sich myeloarchitektonische Felder nur geringf?gig. Es l?sst sich doch noch besonders deutlich auf dem bistri?ren Gebiete des Stirnlappens erkennen, eine Erscheinung, die man auf die starke individuelle Variation der Windungsbildung zur?ckf?hren muss.
en-copyright=
kn-copyright=

en-aut-name=OokumaT.
en-aut-sei=Ookuma
en-aut-mei=T.
kn-aut-name=大熊泰治
kn-aut-sei=大熊
kn-aut-mei=泰治
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學精神病學教室
END

start-ver=1.4
cd-journal=joma
no-vol=40
cd-vols=
no-issue=3
article-no=
start-page=546
end-page=569
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1928
dt-pub=19280331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the regulation of blood coagulation from the pharmacological point of view (Part I) On the mehods of determining both the coagulation time of blood and some coagulative components, and on certain conditions to act upon them
kn-title=藥物學的ニ窺ヒタル血液凝固ノ調節機轉ニ關スル研究 其1 血液凝固時間及ビ凝固要素ノ測定法竝ニ之ニ影響スル諸種ノ條件ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Before the regulation of blood coagulation should be studied pharmacologically, I have, first of all as a means requisite for the desired object, selected out of or improved the existing method of determining both the coagulation time and coagulable components. In the second place, after giving some critical comments on those methods and making carful experiments upon various ploblems that have not yet been solved comprehensively, I have brought to light some conclusive evidences which stand test fairly, as follows: I 1; My own apparatus used for measuring the required time for clotting is but simple. As seen in Fig. 1, two glass-cylinders are put in an oblong kettle, Petres' diches of big size being put in each cylinder. Either cold or hot water or ice-water is filled up in these vessels, in order to keep on a difinite temperature. while the dishes being filled with a piece of gauze well soaked in water. A piece of filter-paper is laid on it, on which a watch-glass is put. The mater to be tested is run dawn on the glass. As for the determination of coagulation time, a hooked glass-thread is used for hooking the matter up at about the middle of it every 15 seconds. The first period of coagulation time lasts until when a tiny piece of fibrin sticks on the end of the glass-thread, and the second period comes to an end as a whole coagulated blood is crear of the face of the watch-glass by means of a glass-rod. This method requires no special skill in practice, and is good for oft-repeated experiments because of a little amount of blood used, and is not only affected by the change of external temperature and humidity, but has also an advantage of pointing out each end of the two periods precisely. 2. While there is an average value of 30 minutes for the coagulation time of a normal rabbit at the temperature ranging from 21°C to 23°C by Fonio's method, my own method takes far less time, an average time for coagulation being 7 minutes at 20°C in the first period, varying from 6.5 to 8 minutes, while taking 15.5 minutes on an average the second period, ranging from 12 minutes to 18.5 minutes. When tried with a single animal, it takes 15 seconds in the first period, and 30 to 45 seconds in the second period respectively, under repeated tests of blood. 3. By my method, as by Fonio's, there is some difference in coagulation time according as the amount of blood used. There exists, however, but little disparity in time in either experiment with a difinite amount used from 0.5 to 2.0 cc by Fonio's method, or with the amount of 2 to 4 gtt. by mine. Any increased amount of blood does not always run parallel to the length of its coagulation time, nor the coagulation is strikingly belated on account of a little amount used. 4. It is an unchangeable fact that the external temperature has no less influence upon the coagulation time. It has been tried by my method at the temperature ranging from 5° to 42°C, marking by drawing a curve line, as do by B?rker's, the result, which shows both the first and second period of coagulation become shorter as the external temperature rises higher. 5. The influence of body temperature upon the coagulation time of blood was inspected by means of heat puncture with a result showing the fact that there is a well-defined parallelism between the curves of the change of body temperature and coagulation time. 6. While it is true that certain amount of carbonic acid in blood plays part in its coagulation time, scholars opinion on the variation of clotting time between the venous and arterial blood has not agreed yet, it has been confirmed the fact that the coagulation time of the former is certainly longer than that of the latter in my own experiments by Fonio's method; but it is not certain whether it is due to only the difference in the tension of carbonic gas. II 1. My methods of measuring fibrinogen, thrombin, anti-thrombin have been much improved based on the principle of Wohlgemuth's methods, are not only good for repeated examinations, but are, also, able to indicate the desired results in a mere fragments of time. 2. Owing to the individuality of animals, the contained amount of those components varies, but when it is repeatedly experimented on the same animal, the result is generally unchangeable. 3. Fibrinogen solution used by myself contains prothrombin. 4. While the potency of serum decreases with the lapse of time, if it is applied to actively, no preeeptible change can be seen in its activity so long as several houres after its being taken out. It is, therefore, best fitted, accompany-ing no great troubles, to use an active serum as thrombin solution in measuring fibrinogen in blood. 5. Serum contains some amount of kinase, yet the amount of calcium in serum is too little for kinase to present itself in its activity, so that the coagulable power of serum on fibrinogen is strengthend when some of calcium is added to the serum in case the power relaxes in both normal condition and wanting in calcium. I doubt kinase will sway a great influence upon my method of measuring thrombin in serum. 6. Hybrid-serum coagulate fibrinogen and transform it into fibrin but the speed of transforming being greatly varied, it may be safely be said the serum has a singular property so far as coagulation time is conserned.
en-copyright=
kn-copyright=

en-aut-name=TanakaHisashi
en-aut-sei=Tanaka
en-aut-mei=Hisashi
kn-aut-name=田中龜
kn-aut-sei=田中
kn-aut-mei=龜
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學藥物學教室
END

start-ver=1.4
cd-journal=joma
no-vol=40
cd-vols=
no-issue=2
article-no=
start-page=205
end-page=214
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1928
dt-pub=19280229
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=小動脉竝ニ毛細血管ニ及ボス藥劑ノ作用ニ就テ
kn-title=On the action of some drugs upon the arterioles and capillaries
en-subtitle=
kn-subtitle=
en-abstract=毛細血管ノ運動(收縮竝ニ擴大)ハ受働的ニシテ夫レト相連續セル小動脉ノ收縮或ハ擴大ノ状態ニヨリテ左右セラレ小動脉ノ擴大ハ毛細血管ニ於ケル壓ノ上昇ヲ來タシタメニ該毛細血管ハ受働的ニ擴大ヲ來タシ壓ノ下降ニ際シテ自身ノ彈力ニヨリテ元ニ復ス事ハ一般ニ信ゼラルル事實ナリ.
然ルニ又一方ニ於テ毛細血管ノ運動ハ單ニ壓ニノミ依ル受働的ノモノニ非ズシテ自働的ニ收縮及ビ擴大ヲ起スト云フ多クノ事實ガ認メラレ其後諸種藥劑ニ依リテ毛細血管ガ血壓ニ關係ナク反應ヲ起ス事實ヲ知ルニ至レリ.又近時或藥品ニ對シテ小動脉及ビ毛細血管ガ反對ノ作用ヲ現ハス事ヲ發見セリ例ヘバAdrenalinハ小動脉ニ對シ收縮性ニ働ラクモ毛細血管ハ之ニ反シ擴大ヲ起ス又Histaminハ小動脉ヲ擴大セシムルモ毛細血管ニハ何等ノ影響ヲ及ボサズ.
予ハ五六ノ藥劑ヲ用ヒテ小動脉竝ニ毛細血管ニ對シ果シテ如何ナル作用ヲ及ボスカヲ見ント欲シ次ノ實驗ヲ行ヘリ即チ蛙ノ蹼膜,腸間膜竝ニ膀胱壁ノ小動脉及ビ毛細血管ヲ顯微鏡下ニ觀察シナガラ各藥劑各種溶液ヲ滴下シ小動脉及ビ毛細管ノ變化ヲ見タリ而シテ次ノ成績ヲ得タリ.
1.芥子油ハ小動脉及ビ毛細血管ヲ共ニ著シク擴大セシム而シテ毛細血管ノ擴大作用ハ血壓ニ無關係ナル事ヲ確カメタリ.
2.「グアニヂン」ニ於テハ0.5%以上ノ濃度ニ於テハ小動脉竝ニ毛細管ヲ共ニ收縮セシムルモ1.0-4.0%ニテハ之ニ反シ擴大作用ヲ有ス.
3.「アドレナリン」ハ小動脉ヲ收縮セシムルモ毛細管ハ反ツテ之ヲ擴大セシム.
4.「ピツイトリン」ハ小動脉ヲ收縮セシメ同時ニ毛細血管ヲ擴大セシム而シテ此作用ハ「アドレナリン」ニ比シ其持續性弱シ.
5.「カフエイン」ハ小動脉竝毛細管ヲ共ニ擴大セシム而シテ毛細管ノ擴大ハ血壓ニ無關係ナリ.
6.「ナトリウム」鹽類ハ概ネ擴大ヲ起スモ「カリウム」鹽類ハ之ヲ收縮セシム「カルチウム」鹽類竝ニ「マグネシウム」鹽類ハ共ニ小動脉竝ニ毛細血管ヲ擴大セシム.
7.「ハイドロキノーン」,「ピロガロール」「フロロガルチン」ハ小動脉竝ニ毛細血管ニ對シ著シキ擴大ヲ起サシム.
kn-abstract=1. Direct application of the mustard-oil to the web, mesentery and bladder wall of frog, caused remarkable dilatation both on the arterioles and capillaries. And capillaries are dilated independently of variation in the arterial blood pressure. 2. A solution of guanidin stronger than 5.0 p. c. has constricting effect upon the arterioles and capillaries, while weak solution (1.0-4.0 p. c.) causes dilatation of the arterioles and capillaries. 3. Adrenalin has contractive effect upon the arterioles but it shows, on the other hand, dilatation of capillaries indepent of variation in the arterial blood pressure. 4. Pituitrin causes contraction of the arterioles, on the contrary, capillaries are always dilated. Its contractive (upon the arterioles) and dilator effect (upon the capillaries) are weaker than that produced with adrenalin. 5. Caffein shows dilator effect both on the arterioles and capillaries. The dilatation of capillaries is independent of variation in the arterial blood pressure. 6. Isotonic solution (with 0.65 p. c. NaCL) of NaNo3, NaNO2 and Na2HPO4 causes slight dilatation of the arterioles and capillaries, while kalium salts (t. i. KCLO, KNO3, KBr etc.) contraction. Calcium salts and magnecium salts have dilator effect both on the arterioles and capillaries. Some organic substances which have reducing ability, have dilator effect upon the arterioles and capillaries.
en-copyright=
kn-copyright=

en-aut-name=OkadaMasanori
en-aut-sei=Okada
en-aut-mei=Masanori
kn-aut-name=岡田正矩
kn-aut-sei=岡田
kn-aut-mei=正矩
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Physiological Department of University Okayama
END

start-ver=1.4
cd-journal=joma
no-vol=42
cd-vols=
no-issue=7
article-no=
start-page=1755
end-page=1780
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1930
dt-pub=19300731
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Effect of the Quinine Derivatives upon the Rabbit's Uterus and It's Appendages, Especially the Interaction with Adrenalin
kn-title=二三「ヒニーン」誘導體ノ家兎子宮竝ニ其附屬器ニ於ケル作用,殊ニ「アドレナリン」トノ相互關係ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effect of the quinine derivatives, such as quinidin, cinchonin, cinchonidin, optochin, eucupin and vuzin, on the isolated uterus, Fallopian tube, round ligament and vaginal wall of the rabbit, is, in low concentration, to exhibit contraction, manifesting increased tonus and movement, through the stimulation of their musculatures, and in high concentration, to exhibit a depressing effect, owing to the paralysis of the muscles. Among these substances, quinidin, cinchonin and cinchonidin, which belong to the cuprein derivatives, and are closely related or isomeric in their chemical constitution to quinine, in a certain degree of concentration (0.005-0.01%) in which usually exert a marked stimulating effect, reverse the stimulating action of adrenalin by paralyzing selectively the motor fibers of the sympathetic nerves of those organs above mentioned. The stimulating action of adrenalin on the organs is reversed, with a pronounced depressive effect, by the subsequent addition of these drugs, and, in similar manner, the stimulating action caused by the quinine derivatives is also markedly depressed by adrenalin afterwards given. The concentrations of the drugs which are required for inducing the reversal of adrenalin action are similar, but in their consistency to cause such phenomena they show considerable variation. Cinchouin is the surest in this respect, followed by cinchonidin and quinidin. Quinine seems to be pretty uncertain. In striking contrast to these cuprein derivatives, the saturated hydrocuprein dervatives such as optochin, eucupin and vuzin have no power to cause the reversal of adrenalin action, except that optochin which has the least molecular weight among them, induces the reversal of adrenalin action very rarely.
en-copyright=
kn-copyright=

en-aut-name=MurakamiKensuke
en-aut-sei=Murakami
en-aut-mei=Kensuke
kn-aut-name=村上憲佑
kn-aut-sei=村上
kn-aut-mei=憲佑
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學藥物學教室
END

start-ver=1.4
cd-journal=joma
no-vol=43
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=20
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1931
dt-pub=19310131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Pharmacology of the Blood Vessels of the Human Umbilical Cord and Placenta Second Communication; On the Effect of the Nerve-muscle Poisons and Muscle Poisons
kn-title=人臍帶血管及ビ胎盤血管ノ藥理學的研究 第2囘報告 二三神經筋毒竝ニ筋毒ノ作用ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In a previous paper published in this journal, the author reported the results of investigations made for the purpose of finding the innervation of the blood vessels of the human umbilical cord and placenta, and the effects of the autonomic nerve poisons such as adrenalin, pilocarpin, acetyl-cholin, physostigmin and atropin on those vessels were also described. Further researches have been made with some of the nerve-muscle poisons and muscle poisons, in order to study the action of those drugs upon these embryonic blood vessels. The results obtained are as follows: 1. Pituitrin, in low concentration, shows vasoconstrictor action on the arteries of the cord and placenta, by acting on the sympathetic nerve as well as on the muscles of the vessels. In high concentration, it causes those arteries to dilate, chiefly by affecting their muscles. The veins of those organs are dilated by this drug, regardless of the degree of concentration, through the effect produced on the vascular muscles. 2. Tyramin shows vasoconstrictor action on the arteries of the cord and placenta, by affecting on the sympathetic nerves of those vessels, in low concentration, while in a higher concentration, it acts on the muscles. Tyramin, in very high concentration, dilates those arteries, but complete paralysis of the muscles is not likely to occur readily. 3. The effect of nicotin on the blood vessels of the umbilical cord and placenta is to dilate them, and the point where it acts is the muscles of the vessels. 4. Calcium affects the muscles of the blood vessels of the cord and placenta, and the dilatation of the vessels results. 5. Secacornin and Bombelon show vasoconstrictor action on the vessels of the cord and placenta. They seem to act mainly on the muscles, and to some extent on the sympathetic nerve as well. As far as the action on the sympathetic nerve is concerned, secacornin is superior to Bombelou and it manifests constrictor action in all cases. Bombelon, in low or moderate concentration, causes vasoconstriction, while dilatation is effected in high concentration. The effect of Bombelon on the muscles, especially its paralyzing action is stronger than that of secacornin. 6. Ergotinin makes the arteries of the cord and placenta dilate, by affecting the muscles of the vessels. 7. Quinine shows vasodilating action on the blood vessels of the cord and placenta by acting on their muscles. In high cocentration, quinine causes complete paralysis of the muscles. 8. Barium acts on the muscles of the vessels of the cord and placenta, thus causing constriction of those vessels. 9. The action of papaverin on the blood vessels of the cord and placenta is to dilate them by affecting the muscles. Paralysis of the muscles is very easily brought about by this drug. 10. The reaction of the drugs on the blood vessels of the umbilical cord and placenta is generally not very evident. The blood vessels of the cord, and those of the placenta, manifest nearly the same reaction to the drugs above mentioned, but considerable variation in the reactions in the arteries and veins is observed.
en-copyright=
kn-copyright=

en-aut-name=MurakamiKensuke
en-aut-sei=Murakami
en-aut-mei=Kensuke
kn-aut-name=村上憲佑
kn-aut-sei=村上
kn-aut-mei=憲佑
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學藥物學教室
END

start-ver=1.4
cd-journal=joma
no-vol=50
cd-vols=
no-issue=11
article-no=
start-page=2135
end-page=2149
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1938
dt-pub=19381130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On the change of Vitamin C content in the Suprarenal Gland of Guinea-pig, suffering from acute diffuse peritonitis
kn-title=海?急性化膿性汎發性腹膜炎ニ於ケル副腎含有「アスコルビン酸」量ノ變化
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Our knowledge concerning vitamin C has made remarkable progress recently. On the other hand, in the surgical domain, especially in case of acute peritonitis, known as one of the prineipal surgical disease, we have very little or no literature on this subject at home and abroad. So the author performed the following experiments witn regard to the hourly change of vitamin C content in the suprarenal gland of guinea-pigs, suffering from acute peritonitis through artificial infection of bac. coli. For the quantitative determination of vitamin C, strict care was taken to avoid harmful factors, which make the results uncertain, eg. only male guinea-pigs (400-500) were used, and the "methylenblue method" after Martini and Bonsignore was adopted, which Ammon and Hinsberg had recommended. As a control, he took preliminary experiments on the effect of starvation to the vitamin C content and confirmed that it diminished as in the case of scurvy. Then in the case of acute peritonitis, this decrease was much more pronounced than that of both former cases. At the same time, he measured variations of the weight of this organ and confirmed that vitamin C was relatively richer in the smaller organ of normal animal and that the vitamin C content and the weight of the organ were in inversed proportion in some cases of peritonitis. Also he observed that the organ of guinea-pigs was generally larger in the left side than in the right. From the fact that the vitamin C content in the suprarenal gland of guinea-pigs, though it diminished as the time passes through starvation, showed a remarkable decrease in the case of peritonitis, it may be concluded that there exists an intimate relation between the inflammation and vitamin C, so far as other conditions are constant.
en-copyright=
kn-copyright=

en-aut-name=MiyagiTeruo
en-aut-sei=Miyagi
en-aut-mei=Teruo
kn-aut-name=宮木輝夫
kn-aut-sei=宮木
kn-aut-mei=輝夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學津田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=51
cd-vols=
no-issue=1
article-no=
start-page=104
end-page=123
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1939
dt-pub=19390131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Influence of Combustion on the Change of Ascorbic Acid Content and of Histological Structure in the Suprarenal Gland of Guinea-pigs
kn-title=火傷ノ海?副腎含有「アスコルビン酸」量ニ及ボス影響竝ニ其ノ病理組織學的變化
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author took experimental investigations concerning the variations of ascorbic acid content as well as the change of histological structure in the suprarenal gland of guinea-pigs, which had been fed with vitamin-C diet for several days before the experimentation and were submitted to combustion of considerable degree at the back and the lateral region of the abdomen after shaving. The results may be summarized as followings: 1) Ascorbic acid content in the suprarenal gland of guinea-pigs suffering from combustion decreases gradually as time progresses. Its decreasing ratio is greater than the control normal animal and most remarkably contrasted especially in an earlier stage after the combustion. 2) The decrease of ascorbic acid content in the suprarenal gland of guinea-pigs suffering from combustion is greater in amount according as the degree of combustion is serious. 3) It may be pointed out as principal changes of the histological structure due to combustion in the suprarenal gland that the decrease of lipoid substances, atrophy, swelling and necrosis of cell, karyolysis and karyoklasis, vasodilatation, hyperaemia and blood stagnation in cortex; vacuole formation in medulla. 4) These histological changes, though manifold according to the degree of combustion and to the time course after it, are most prominent in reticular and fascicular zones in the suprarenal gland. 5) Lipoid substances in the suprarenal gland after the combustion are almost disappeared in the haemorrhagic and necrotic areas. 6) Although there are parallel relations between the decrease of ascorbic acid content and the change of histological structure in the suprarenal gland after the combustion, occurrence of the former precedes in time than the latter. 7) It is concluded that the decrease of ascorbic acid content and the change of histological structure in the suprarenal gland after the combustion are due to the action of toxin produced by combustion.
en-copyright=
kn-copyright=

en-aut-name=MiyagiTeruo
en-aut-sei=Miyagi
en-aut-mei=Teruo
kn-aut-name=宮木輝夫
kn-aut-sei=宮木
kn-aut-mei=輝夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學津田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=11
article-no=
start-page=2729
end-page=2753
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1940
dt-pub=19401130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Rachitis of Newborns. (Part 6) The inorganic phosphorus and total calcium contents in the blood serum of the newborn and the mother at the time of deliverly, and the lowest limit of the normal range of the inorganic phosphorus content of the blood serum of the newborn.
kn-title=新産兒佝僂病問題ニ就テノ檢討（第6報）新産兒及ビ分娩時母體ノ血清無機燐量竝ニ血清總「カルシウム」量，及ビ新産兒ニ於ケル夫等量値ノ正常範圍下限界ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The determinations were made with the blood serum from the umblical cord at the time of labour and with the blood serum of mother obtained shortly thereafter, comprising some two hundreds infants and their mothers. In the infant the average percentage of inorganic phosphorus was 4.91±0.486mg., and that of total calcium was 10.41±0.699mg.: in the mother the average percentage of inorganic phosphorus was 3.10±0.333mg., and that of total calcium was 8.83±0.586mg. It is apparent that the contents of the inorganic phosphorus and total calcium in the serum of the newborn is higher than those of the mother's serum. Regarding the inorganic phosphorus content, a positive correlation was shown between the infant and its mother; this held true, though to a less extent, also for the calcium content. These suggest the existence of certain relationship between the maternal condition during pregnancy and the state of well being of the fetus. The inorganic phosphorus content of the mother's blood is more constant and has a narrow range of variation than that of the newborn.
The content of the inorganic phosphorus of the serum of the newborn tends to fall during the Winter and Spring and to rise during the Summer months. This holds true, though less marked, also for the serum of the mother. On the basis of results of the present studies, it is suggested that the lowest limit of the norml range of the inorganic phosphorus content may be regarded as about a little sbove 5.0mg. per hundred cubic centimeter of serum, and lower range than this may indicates the existence of certain faulty biochemical reaction in the fetus, such as rachitis or prserachitic state.
en-copyright=
kn-copyright=

en-aut-name=TakaharaAkio
en-aut-sei=Takahara
en-aut-mei=Akio
kn-aut-name=高原章夫
kn-aut-sei=高原
kn-aut-mei=章夫
aut-affil-num=1
ORCID=

en-aut-name=KuyamaKiniti
en-aut-sei=Kuyama
en-aut-mei=Kiniti
kn-aut-name=久山謹一
kn-aut-sei=久山
kn-aut-mei=謹一
aut-affil-num=2
ORCID=

en-aut-name=IsikawaNoboru
en-aut-sei=Isikawa
en-aut-mei=Noboru
kn-aut-name=石川昂
kn-aut-sei=石川
kn-aut-mei=昂
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學小兒科教室

affil-num=2
en-affil=
kn-affil=岡山醫科大學小兒科教室

affil-num=3
en-affil=
kn-affil=岡山醫科大學産婦人科教室
END

start-ver=1.4
cd-journal=joma
no-vol=53
cd-vols=
no-issue=9
article-no=
start-page=1931
end-page=1944
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1941
dt-pub=19410930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studien ?ber die Hamazakischen Ketoenolsubstanzen im menschlichen Harn. I. Mitteilung. Systematische Untersuchungen der verschiedenen Bedingungen f?r die Niederschlagsbildung der Hamazakiscben Ketoenolsubstanzen im Harn. 2. ?ber den Einfluss des spezifischen Gewichts
kn-title=人尿中ニ排泄サルル濱崎氏「ケトエノール物質」ノ研究（第1報）「尿ケトエノール物質」ノ沈澱形成條件ニ關スル系統的研究 第2篇 尿比重，尿稀釋度及ビ尿「水素イオン濃度」トノ關係ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In der vorhergehenden Mitteilung hat der Verf. uber die Wirkungen der einzelnen Komponenten der Reagenzien anf die Niederschlagsbildung der Ketoenolsubstanzen (KES) im Harn berichtet. In der vorliegenden Mitteilung untersucht er die Zusammenh?nge zwischen der Niederschlagsbildung der KES im Harn und dem spezifischen Gewicht, dem Verd?nnungsgrad und der Wasserstoffionenkonzentration des Harns. Die Ergebnisse lassen sich kurz folgendermassen zusammenfassen; 1) Bei 1461 Fallen von gesunden Mannern im Alter von 20-50 Jahren beobachtete der Verf. statistisch quantitative Schwankungen des KES-Niederschlags im Harn. Es ergab sich, dass der KES-Niederschlag im Harn statistisch einen um so bedeutsameren Mengenzuwachs zeigte, je schwerer das spezifische Gewicht des Harns war. Der mittlere Fehler des arithmetischen Mittelwertes (M) und der Variations-Koeffizient (V) waren aber auffallend gross. 2) Aus der Festetellung der aufgez?hlten H?ufigkeitsverteilung ergab sich, dass die Menge des KES-Niederschlags bei 33% der Untersuchten 1461 F?lle weniger als 0,010 betrug, bei 60% weniger als 0,020 und bei 92% weniger als 0,050. 3) Bei den KES, welche aus dem Harn von leichterem spezifischem Gewicht gewonnen wurden, waren die makroskopischen sowie die mikroskopischen Befunde im Vergleich zu den KES, welche aus dem Harn von schwererem spezifischem Gewicht herausgezogen wurdep, verhaltnism?ssig mehr typisch. 4) Zwischen der durch die Karbolfuchsin-Jod Methode herbeigef?hrten Farbreaktion sowie der mittels Ciaccioscher Lipoidfarbung dargestellten sudanophilen Eigenschaft der KES im Harn und dem spezifischen Gewicht des Harns ist kein Zusammenhang feststellbar. 5) Wenn die KES im Harn nicht in typischer Weise Niederschlag bilden wollen, so muss man den Harn vorher mit destilliertem Wasser auf 3:7 und darunter oder mit Reagenzien auf 5:5 und darunter verd?nnen. 6) Wenn die KES im Harn, der vorher mit destilliertem Wasser oder Reagenzien angemessen verd?nnt wurde, ausgef?llt werden, mimmt die Menge der niedergeschlagenen KES und die Zahl der sudanophilen K?rnchen auffallend stark ab, und zwar in einem viel grosseren Masse als beim verdunnten Grade. 7) Zwischen der Wasserstoffionenkonzentration und der Niederschlagsbildung der KES im Harn ist keine erw?hnenswerte Beziehung zu beobachten.
en-copyright=
kn-copyright=

en-aut-name=YamakawaTakesi
en-aut-sei=Yamakawa
en-aut-mei=Takesi
kn-aut-name=山川斌
kn-aut-sei=山川
kn-aut-mei=斌
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學病理學教室
END

start-ver=1.4
cd-journal=joma
no-vol=54
cd-vols=
no-issue=2
article-no=
start-page=242
end-page=258
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1942
dt-pub=19420228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Rachitis of Newborns (Part 7) So-called Congenital Craniotabes
kn-title=新産兒佝僂病問題ニ就テノ檢討（第7報）新産兒ノ所謂先天性頭蓋癆ニ就テ，殊ニ又夫等新産兒ノ血清化學的所見トノ對比
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The present study was undertaken with the hope of throwing more light on a condition found in newborn infants and on the problem of the rachitis of newborn. The most frequent location of so-called congenital craniotabes is the regions along the course of the sagittal suture. It occurs in about 25,5 per cent of all full-term newborn infants. There is a slight seasonal variation in its frequency, with winter as the most favourable season for its occurence. It shows a predilection for infants of the lower birth weight, smaller head circumference, larger fontanel, separated sutures with soft edges, enlarged costochondral junctions and younger primipara. The phosphorus content in the blood serum of newborn infants with the craniotabes and their mothers is slightly lower that of newborn infants without the craniotabes and their mothers. It is suggested that so-called congenital craniotabes should be considered not as a physiologic, but a pathologic manifestation, and as being influenced by such factors, as the maternal nutrition and health during pregnancy.
en-copyright=
kn-copyright=

en-aut-name=TakaharaAkio
en-aut-sei=Takahara
en-aut-mei=Akio
kn-aut-name=高原章夫
kn-aut-sei=高原
kn-aut-mei=章夫
aut-affil-num=1
ORCID=

en-aut-name=YosinoSyungo
en-aut-sei=Yosino
en-aut-mei=Syungo
kn-aut-name=芳野俊五
kn-aut-sei=芳野
kn-aut-mei=俊五
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學小兒科教室

affil-num=2
en-affil=
kn-affil=岡山醫科大學小兒科教室
END

start-ver=1.4
cd-journal=joma
no-vol=55
cd-vols=
no-issue=1
article-no=
start-page=111
end-page=123
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1943
dt-pub=19430131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Die Studien uber Vitamin-C in der Nebenniere. (II. Teil.)
kn-title=副腎「ビタミンC」ノ研究（第2囘）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Im Anschluss an die erste Mitteilung hat nun der Verf. Untersuchungen an Kaninchen auf das Verhalten des Vitamin-C in der Nebenniere angestellt und kam zu folgenden Ergebnissen: 1. Bei Kaninchen, denen Atropinsulfat 30mg pro K?rperkilogramm subkutan injiziert worden war, wies das Vitamin-C (V.-C) in der Nebenniere bei dem durch den Nervus vagus zugeleiteten elektrischen Reiz fast keine quantitative Ver?nderung auf. Wenn der Reiz den Nervus splanchnicus traf, so zeigte das V.-C eine auffallend starke Zunahme (18,3%), wahrend es ferner durch den Reiz, der den Bauchsympathicus traf, geheinmt wurde, abzunehmen. 2. Bei Kaninchen, denen Adrenalin chlorid 0.15mg pro Kg unter die Haut injiziert worden war, antwortete das V.-C auf den durch den Nervus vagus zugeleiteten Reiz mit einer leichtgradigen Abnahme (6,7%), auf den durch den Nervus splanchnicus zugeleiteten Reiz aber mit einer leichtgradigen Zunahme (3,1%). 3. Wenn das in der Peripherie der Nebenniere befindliche Ganglion mit 0,5% iger Nikotinl?sung aufgestrichen wurde, so erlitt das V.-C durch den Reiz des Nervus vagus eine erhebliche Verringerung (13,4%), durch den Reiz des Nervus splanchnicus eine geringf?gige (1,6%), durch den Reiz des Bauchsympathicus eine noch etwas st?rkere, Verringerung (5,6%). 4. Bei Kaninchen, denen das Pilokarpin hydrochloricum in der Menge von 3mg pro K?rperkilogramm subkutan einverleibt worden war, . nahm das V.-C in der Nebenniere durch den Reiz des Nervus vagus ab (4,5%) wahrend es durch den Reiz des Nervus splanchnicus zunahm (7,8%). 5. An der Hautreaktion des V.-C war noch keine Variation erkennbar, wenn auch bei den Kaninchen durch die Injektion von Adrenalin, Pilokarpin oder Atropin quantitative Ver?nderungen des V.-C in der Nebenniere hervorgerufen worden waren. Auf diese Weise hat der Verf. bei Kaninchen durch Anwendung verschiedener Gifte fur autonome Nerven die Innervation des Nervus vagus, splanchnicus und des Bauchsympathicus auf das Verhalten des V.-C in der ebenniere festgestellt und dadurch die Ergebnisse der ersten Mitteilung best?tigt.
en-copyright=
kn-copyright=

en-aut-name=IsokawaJosuke
en-aut-sei=Isokawa
en-aut-mei=Josuke
kn-aut-name=礒川恕介
kn-aut-sei=礒川
kn-aut-mei=恕介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學北山内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=56
cd-vols=
no-issue=2
article-no=
start-page=118
end-page=126
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1944
dt-pub=19440229
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Action current of the compound eye of some insects
kn-title=複眼ノ活動電流
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Since the discovery of Holmgren, the retinal action current has been investigated by many authors; recently Hartline on limulus, Jahn and Crescitteli on grasshopper, and Adrian on water beetle. The author studied on this subject using the compound eyes of grasshopper (Locusta danica), locust, water beetle (Cybister japonica) and fire-fly (Luciola cruciata). The experimental procedure and the results are in short, summarized as follows: Method: The retinal action current from the eye of decapitated animals was obtained with a pair of nonpolarizable electrode, placing the one on the decapitated cut end and the other on the surface of the cornea, and the current was recorded by Siemen's oscillograph. A small electric lamp from short distance was employed as stimulus. Results: 1) When the eye was stimulated by allight, a complex effect, i.e. after a small positive deflection (a-wave), soon followed by a sharp negative one (b-wave), after which a very slower one (c-wave) was observed. When the lithdrawn, there occurred also an off-effect (d wave). These waves coincide with those observed on frog's retina, indicating that three different processes occur together in the stimulated retina. 2) The magnitude of the deflection of b-wave increased with the duration of dark adaptation.  3) The magnitude of the deflection of b-wave was proportinal to the strength of the light. 4) Among amylalcohol, cocain, taurocholic acid and digitonine, when applied to the eye externally, the most effective drug, which diminishes the magnitude of the negative variation of retinal action current, was digitonine, while other drugs have little or no effect. 5) From the fact that cocain has no effect, we can conclude that the action current of retina does not depend on nervous element, but depends on the photosensitive substance which was dissolved out and disintegrated by digitonine. The substance is perhaps photosensitive substance in cone, because grasshopper retina has no rods.
en-copyright=
kn-copyright=

en-aut-name=K?noMinoru
en-aut-sei=K?no
en-aut-mei=Minoru
kn-aut-name=河野實
kn-aut-sei=河野
kn-aut-mei=實
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學生理學教室
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=11-12
article-no=
start-page=697
end-page=702
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1964
dt-pub=19641230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Electrocardiogram before and after operation
kn-title=手術前後の心電図
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=ECGs were examined in 88 cases before and after operation. After operation, ECG was taken on the second, fourth and sixth day. Fourty-two cases (48%) showed some changes in ECG after operation.
Patients with gastric cancer showed some changes most frequently (63%). Among the post operative changes, T wave change was more common. Hypertension, bleeding, variation of blood pressure during operation and operation time had influence on the ECG. Serum potassium was prove to be lowered after operaiion.
en-copyright=
kn-copyright=

en-aut-name=HaraokaShoichi
en-aut-sei=Haraoka
en-aut-mei=Shoichi
kn-aut-name=原岡昭一
kn-aut-sei=原岡
kn-aut-mei=昭一
aut-affil-num=1
ORCID=

en-aut-name=HayashiChikara
en-aut-sei=Hayashi
en-aut-mei=Chikara
kn-aut-name=林力
kn-aut-sei=林
kn-aut-mei=力
aut-affil-num=2
ORCID=

en-aut-name=SatoMichihiko
en-aut-sei=Sato
en-aut-mei=Michihiko
kn-aut-name=佐藤迪彦
kn-aut-sei=佐藤
kn-aut-mei=迪彦
aut-affil-num=3
ORCID=

en-aut-name=HatanoYoshihiro
en-aut-sei=Hatano
en-aut-mei=Yoshihiro
kn-aut-name=波多野淑弘
kn-aut-sei=波多野
kn-aut-mei=淑弘
aut-affil-num=4
ORCID=

en-aut-name=ShiinaHiroshi
en-aut-sei=Shiina
en-aut-mei=Hiroshi
kn-aut-name=椎名宏
kn-aut-sei=椎名
kn-aut-mei=宏
aut-affil-num=5
ORCID=

en-aut-name=TanakaAkira
en-aut-sei=Tanaka
en-aut-mei=Akira
kn-aut-name=田中昭
kn-aut-sei=田中
kn-aut-mei=昭
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部中央検査部

affil-num=2
en-affil=
kn-affil=岡山大学医学部中央検査部

affil-num=3
en-affil=
kn-affil=岡山大学医学部中央検査部

affil-num=4
en-affil=
kn-affil=岡山大学医学部中央検査部

affil-num=5
en-affil=
kn-affil=岡山大学医学部中央検査部

affil-num=6
en-affil=
kn-affil=岡山大学医学部中央検査部
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=10
article-no=
start-page=2111
end-page=2123
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19541030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=STUDY ON VITAMIN B(1) IN DERMATOLOGIC DISORDERS Part I on the Blood Level of Vitamin B(1) in Dermatologic Disorders
kn-title=皮膚科領域におけるVitamin B(1)の研究 第1編 皮膚疾患における血中総B(1)量について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The blood level of Vitamin B(1) in 80 cases of various dermatologic disorders was defermined with thiochrome method using permutit and considering the value of the healthy individuals and the results of other investigators, the minimum limit was established on 6.0γ% and the following results were obtained: 1) In 17 cases of healthy individuals, the average of the blood level of total Vit. B(1) was 8.34γ%, and it presented lower value in summer rather compared with in autumm. The average of the blood level of Vit. B(1) in dermatologic disorders was 6.51γ%, i.e., 1.83γ% lower than in the healthy individuals. 2) Concerning eczema acutum, it showed normal value in erythematous and desquamatous stadium. but in the rest of the stadium most of them showed lower value, in eczema chronicum it also showed lower value in cases in which the course was prolonged. 3) In dermatitis acuta and Duhring's dermatitis, the blood level of Vit. B(1) decreased in cases in which excessive exsudation could be seen, pemphigus, Domian enanthem and pellagra showed obvious deficiency of Vit. B(1). Moreover, in most of the cases of erythematodes and psoriasis vulgaris showed Vit. B(1) deficiency, but in acne vulgaris, alopecia arezta, chloasma and erythema induratum Bazin showed normal value. 4) Vit. B(1) takes part in the metabolism with close relation with the functions of many organs, as well as with other Vitamins and endocrine system; so the variation of the blood level of Vit. B(1) might not be attributed as the only cause of the previous diseases, but it could be concluded that in some of the cases, the deficiency of Vit. B(1) takes an important roll in the cause or degeneration of dermatologic diseases.
en-copyright=
kn-copyright=

en-aut-name=IchiyamaTaisuke
en-aut-sei=Ichiyama
en-aut-mei=Taisuke
kn-aut-name=市山泰典
kn-aut-sei=市山
kn-aut-mei=泰典
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部皮膚科泌尿器科教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=9
article-no=
start-page=1885
end-page=1892
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=STUDIES ON THE RENAL FUNCTION IN RENAL AND URETERAL CALCULUS PART IV. RENAL FUNCTION DURING THE COLIC ATTACK IN RENAL AND URETERAL CALCULUS
kn-title=腎石症及び尿管石症における腎機能の研究 第4編 腎石症及び尿管石症疝痛発作時における腎機能の研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=As a colic attack is mentioned as one of the most important symptoms of the renal and ureteral calculus, it appears considerably frequent in them, but studies on renal function during the colic attack, especially on the influence of colic upon the fluid test, could not be found. So. as a part of the studies on renal function in renal and ureteral calculus, here in this Part IV. I made some researches on this problem, and examined the variation of the quantity and specific gravity of urine during the colic attack, so as to investigate the influence of the colic upon excretion and concentration abilities. Besides, the daily urinary quantity on which the colic broke out was also studied and the following results were obtained (1) The materials for the study on fluid test during the colic attack were 3 cases of renal calculus, 3 cases of ureteral calculus and 1 case of both renal and ureteral calculus. (2) The influence of colic attack upon renal function appeared as a hindrance of excretory ability, and all of the 7 cases showed decrease of urinary excretion. The extent of the urinary decrease depended on the severity of the colic. i.e., when stronger the colic the higher the rate of decrease. (3) The improvement of the excretory hindrance was comparatively rapid, and the time needed for improvement depended on the duration of the colic rather than the severity of it, so the longer the duration the slower the improvement. (4) Concerning the influence of the colic attack upon the daily urinary quantity in 2 cases of renal and 8 cases of ureteral calculus, 9 cases showed decrease of the daily urinary quantity and one showed increase. The extent of the decrease in urinary excreiton depended on the duration rather than the severity of the colic, and the longer the duration the higherthe extent of urinary decrease. (5) No special relation could be found between the size of the stone, indigocarmin and phenolsulfonphthalein excretion and the decrease of urinary quantity.
en-copyright=
kn-copyright=

en-aut-name=TanabeKiyoshi
en-aut-sei=Tanabe
en-aut-mei=Kiyoshi
kn-aut-name=田辺澄
kn-aut-sei=田辺
kn-aut-mei=澄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部皮膚科泌尿器科教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=8
article-no=
start-page=1625
end-page=1633
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Phosphatases in Malignant Tumor III. Experimental studies on the influence of cancer on the contents of adrenal gland phosphatase in rabbits
kn-title=惡性腫瘍疾患に於けるPhosphataseの研究 第3編 家兎副腎のPhosphataseに及ぼす影響に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By injecting urine specimens taken from patients with cancer, a variation of the contents of adrenal gland phesphatase in rabbits was observed. And the following results were obtained. 1) In normal rabbit, the average value of acid tissue phosphatase was higher than that of alkaline tissue phosphatase. 2) When the urine-extract or urine from normal adults and patients with non-malignant tumor was injected subcutaneously or intravenously, the variation of acid and alkaline adrenal gland phosphatase contents was very small. 3) When urine-extract from patients with malignant tumor was injected an increase of alkaline phosphatase contents was observed, but the increase of acid phosphatase contents was small. The value of acid and alkaline phosphatase was found normal in only those where urine-extract from patients undergoing X-ray therapy or nitrogenmusterd treatment was used for injection. 4) When urine, taken from partients with Bantis disease or other malignant tumors, were injected the same results were obtained as described above.
en-copyright=
kn-copyright=

en-aut-name=KoshimuneYukishige
en-aut-sei=Koshimune
en-aut-mei=Yukishige
kn-aut-name=越宗幸重
kn-aut-sei=越宗
kn-aut-mei=幸重
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部津田外科教室
END