検索結果 - 岡山大学学術成果リポジトリ

Guideline-based Treatment of Glucocorticoid-induced Osteoporosis in Patients with Rheumatoid Arthritis: A Retrospective Study with the AORA Registry

JaLCDOI	10.18926/AMO/62809
フルテキストURL	75_6_699.pdf
著者	Kawano, Tetsuya\| Miyakoshi, Naohisa\| Tsuchie, Hiroyuki\| Kashiwagura, Takeshi\| Kobayashi, Moto\| Aonuma, Hiroshi\| Sugimura, Yusuke\| Shimada, Yoichi\|
抄録	Glucocorticoid-induced osteoporosis (GIOP) is one of the side effects associated with glucocorticoid (GC) therapy. In 2014, the Japanese Society for Bone and Mineral Research (JSBMR) provided new guidelines for the management and treatment of GIOP. The aim of the present study was to clarify the prevalence of patients with rheumatoid arthritis (RA) requiring treatment according to the new guidelines and to identify risk factors associated with lack of treatment in these patients. Patients in the 2018 Akita Orthopedic group on Rheumatoid Arthritis (AORA) database were enrolled. Of 2,234 patients with RA in the database, 683 (30.6%) met the 2014 JSBMR guideline treatment criteria, and 480 (70.3%) had been treated. The untreated group included a larger number of males, younger patients, and patients treated in clinics rather than hospital (p<0.001, p=0.015, and p<0.001, respectively). Multivariate analyses found that male sex, younger age, and clinic-based RA care were significant risk factors associated with lack of treatment (p<0.001, p=0.013, and p<0.001, respectively). Thus, male sex, younger age, and clinic-based care were identified as risk factors
キーワード	glucocorticoid glucocorticoid-induced osteoporosis rheumatoid arthritis osteoporosis osteopenia
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	699
終了ページ	704
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955537
Web of Science KeyUT	000735297900005
NAID	120007180283

Glial Cells as Possible Targets of Neuroprotection through Neurotrophic and Antioxidative Molecules in the Central and Enteric Nervous Systems in Parkinson’s Disease

JaLCDOI	10.18926/AMO/62767
フルテキストURL	75_5_549.pdf
著者	Isooka, Nami\| Miyazaki, Ikuko\| Asanuma, Masato\|
抄録	Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. The loss of nigrostriatal dopaminergic neurons produces its characteristic motor symptoms, but PD patients also have non-motor symptoms such as constipation and orthostatic hypotension. The pathological hallmark of PD is the presence of α-synuclein-containing Lewy bodies and neurites in the brain. However, the PD pathology is observed in not only the central nervous system (CNS) but also in parts of the peripheral nervous system such as the enteric nervous system (ENS). Since constipation is a typical prodromal non-motor symptom in PD, often preceding motor symptoms by 10-20 years, it has been hypothesized that PD pathology propagates from the ENS to the CNS via the vagal nerve. Discovery of pharmacological and other methods to halt this progression of neurodegeneration in PD has the potential to improve millions of lives. Astrocytes protect neurons in the CNS by secretion of neurotrophic and antioxidative factors. Similarly, astrocyte-like enteric glial cells (EGCs) are known to secrete neuroprotective factors in the ENS. In this article, we summarize the neuroprotective function of astrocytes and EGCs and discuss therapeutic strategies for the prevention of neurodegeneration in PD targeting neurotrophic and antioxidative molecules in glial cells.
キーワード	Parkinson’s disease astrocyte enteric glial cell neurotrophic factor antioxidative molecule
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2021-10
巻	75巻
号	5号
出版者	Okayama University Medical School
開始ページ	549
終了ページ	556
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34703037
Web of Science KeyUT	000711561600001
NAID	120007166678

A structural model for (GlcNAc)2 translocation via a periplasmic chitooligosaccharide-binding protein from marine Vibrio bacteria

フルテキストURL	fulltext20211118-1.pdf
著者	Kitaoku, Yoshihito\| Fukamizo, Tamo\| Kumsaoad, Sawitree\| Ubonbal, Prakayfun\| Robinson, Robert C.\| Suginta, Wipa\|
発行日	2021-09-30
出版物タイトル	Journal of Biological Chemistry
巻	297巻
出版者	Elsevier Inc
開始ページ	101071
ISSN	00219258
NCID	AA00251083
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.
論文のバージョン	publisher
PubMed ID	34400168
DOI	10.1016/j.jbc.2021.101071
Web of Science KeyUT	000714635500005
関連URL	isVersionOf https://doi.org/10.1016/j.jbc.2021.101071

The eco‐evolutionary dynamics of prior selfing rates promote coexistence without niche partitioning under conditions of reproductive interference

フルテキストURL	fulltext20210928-2.pdf
著者	Katsuhara, Koki\| Tachiki, Yuuya\| Iritani, Ryosuke\| Ushimaru, Atushi\|
キーワード	Co-evolution evolutionary rescue inbreeding depression individual-based model mixed mating pollinator-mediated competition reproductive ecology selfing syndrome
備考	This is the peer reviewed version of the following article: [Katsuhara, K. R., Tachiki, Y., Iritani, R., & Ushimaru, A. (2021). The eco-evolutionary dynamics of prior selfing rates promote coexistence without niche partitioning under conditions of reproductive interference. Journal of Ecology, 00, 1–13], which has been published in final form at [https://doi.org/10.1111/1365-2745.13768]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-ArchivedVersions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wileyor by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked toWiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof bythird parties from platforms, services and websites other than Wiley Online Library must be prohibited. This fulltext is available in Sep. 2022.\|
発行日	2021-9-16
出版物タイトル	Journal of Ecology
巻	109巻
号	11号
出版者	Wiley
開始ページ	3916
終了ページ	3928
ISSN	0022-0477
NCID	AA00696840
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 British Ecological Society
論文のバージョン	author
DOI	10.1111/1365-2745.13768
Web of Science KeyUT	000696397800001
関連URL	isVersionOf https://doi.org/10.1111/1365-2745.13768

Design and validation of microfluidic parameters of a microfluidic chip using fluid dynamics

フルテキストURL	fulltext.pdf
著者	Ahmed, Feroz\| Yoshida, Yuichi\| Wang, Jin\| Sakai, Kenji\| Kiwa, Toshihiko\|
発行日	2021-07-26
出版物タイトル	AIP Advances
巻	11巻
号	7号
出版者	AIP Publishing
開始ページ	75224
ISSN	2158-3226
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Author(s).
論文のバージョン	publisher
DOI	10.1063/5.0056597
Web of Science KeyUT	000692318200001
関連URL	isVersionOf https://doi.org/10.1063/5.0056597

Assessment of the Concordance Rate between Intraoperative Pathological Diagnosis and the Final Pathological Diagnosis of Spinal Cord Tumors

JaLCDOI	10.18926/AMO/62397
フルテキストURL	75_4_455.pdf
著者	Muraoka, Sosuke\| Yamane, Kentaro\| Misawa, Haruo\| Takigawa, Tomoyuki\| Tetsunaga, Tomoko\| Oda, Yoshiaki\| Nakanishi, Kazuo\| Ozaki, Toshifumi\| Tanaka, Takehiro\|
抄録	The intraoperative pathological diagnosis (IPD) plays an important role in determining the optimal surgical treatment for spinal cord tumors. The final pathological diagnosis (FPD) is sometimes different from the IPD. Here, we sought to identify the accuracy of the IPD of spinal cord tumors compared to the FPD. We retrospec-tively analyzed the cases of 108 patients with spinal cord tumors treated surgically in our institute; the IPD, FPD, mismatched cases, and concordance rate between the IPD and FPD were investigated. Five cases involved a mismatch between the IPD and FPD. The overall concordance rate was 95.4%, with 90.9% for extra-dural lesions, 98.5% for intradural extramedullary lesions, 84.2% for intramedullary lesions, and 100% for dumbbell-type tumors. The concordance rate of intramedullary lesions tended to be lower than that of other lesions (p = 0.096). A lower concordance rate was revealed for intramedullary lesions compared to the other lesions. Despite the IPD clearly remaining a valuable tool during operative procedures, surgeons should recog-nize the limitations of IPDs and make comprehensive decisions about surgical treatments.
キーワード	spinal cord tumor intraoperative pathological diagnosis final pathological diagnosis concordance rate
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	455
終了ページ	460
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511612
Web of Science KeyUT	000697944600007
NAID	120007146040

Macrophage Motility in Wound Healing Is Regulated by HIF-1 alpha via S1P Signaling

フルテキストURL	fulltext.pdf
著者	Hutami, Islamy Rahma\| Izawa, Takashi\| Khurel-Ochir, Tsendsuren\| Sakamaki, Takuma\| Iwasa, Akihiko\| Tanaka, Eiji\|
キーワード	HIF1 M1/M2 macrophage S1P wound healing
発行日	2021-08-20
出版物タイトル	International Journal of Molecular Sciences
巻	22巻
号	16号
出版者	MDPI
開始ページ	8992
ISSN	1422-0067
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors.
論文のバージョン	publisher
PubMed ID	34445695
DOI	10.3390/ijms22168992
Web of Science KeyUT	000689169900001
関連URL	isVersionOf https://doi.org/10.3390/ijms22168992

Discovery and Validation of Nitroxoline as a Novel STAT3 Inhibitor in Drug-resistant Urothelial Bladder Cancer

フルテキストURL	fulltext.pdf
著者	Lin, Wenfeng\| Sun, Jingkai\| Sadahira, Takuya\| Xu, Naijin\| Wada, Koichiro\| Liu, Chunxiao\| Araki, Motoo\| Xu, Abai\| Watanabe, Masami\| Nasu, Yasutomo\| Huang, Peng\|
キーワード	Urothelial bladder cancer doxorubicin cisplatin chemoresistance nitroxoline STAT3
発行日	2021-07-25
出版物タイトル	International Journal of Biological Sciences
巻	17巻
号	12号
出版者	Ivyspring International Publisher
開始ページ	3255
終了ページ	3267
ISSN	1449-2288
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The author(s).
論文のバージョン	publisher
DOI	10.7150/ijbs.63125
Web of Science KeyUT	000682847000007
関連URL	isVersionOf https://doi.org/10.7150/ijbs.63125

A second capsidless hadakavirus strain with 10 positive-sense single-stranded RNA genomic segments from Fusarium nygamai

フルテキストURL	Arch Virol, HadV1-1NL_Manuscript SUZUKI.pdf
著者	Khan, Haris Ahmed\| Sato, Yukiyo\| Kondo, Hideki\| Jamal, Atif\| Bhatti, Muhammad Faraz\| Suzuki, Nobuhiro\|
備考	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00705-021-05176-x\|
発行日	2021-7-27
出版物タイトル	Archives of Virology
巻	166巻
出版者	Springer Science and Business Media LLC
開始ページ	2711
終了ページ	2722
ISSN	0304-8608
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Springer Nature Switzerland AG
論文のバージョン	author
PubMed ID	34313859
DOI	10.1007/s00705-021-05176-x
Web of Science KeyUT	000678003000001
関連URL	isVersionOf https://doi.org/10.1007/s00705-021-05176-x

The Origin of Stroma Influences the Biological Characteristics of Oral Squamous Cell Carcinoma

フルテキストURL	fulltext.pdf
著者	Omori, Haruka\| Shan, Qiusheng\| Takabatake, Kiyofumi\| Nakano, Keisuke\| Kawai, Hotaka\| Sukegawa, Shintaro\| Tsujigiwa, Hidetsugu\| Nagatsuka, Hitoshi\|
キーワード	gingival ligament tissue-derived stromal cells periodontal ligament tissue-derived stromal cells oral squamous cell carcinoma tumor microenvironment biological character
発行日	2021-07-12
出版物タイトル	Cancers
巻	13巻
号	14号
出版者	MDPI
開始ページ	3491
ISSN	2072-6694
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors.
論文のバージョン	publisher
PubMed ID	34298705
DOI	10.3390/cancers13143491
Web of Science KeyUT	000676184700001
関連URL	isVersionOf https://doi.org/10.3390/cancers13143491

PC3-secreted microprotein is expressed in glioblastoma stem-like cells and human glioma tissues

フルテキストURL	fulltext20210803-2.pdf
著者	Maruyama, Masato\| Nakano, Yousuke\| Nishimura, Takuya\| Iwata, Ryoichi\| Matsuda, Satoshi\| Hayashi, Mikio\| Nakai, Yuki\| Nonaka, Masahiro\| Sugimoto, Tetsuo\|
発行日	2021-07
出版物タイトル	Biological and Pharmaceutical Bulletin
巻	44巻
号	7号
出版者	Pharmaceutical Society of Japan
開始ページ	910
終了ページ	919
ISSN	0918-6158
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Pharmaceutical Society of Japan
論文のバージョン	publisher
PubMed ID	33896885
DOI	10.1248/bpb.b20-00868
Web of Science KeyUT	000668371900003
関連URL	isVersionOf https://doi.org/10.1248/bpb.b20-00868

Development of a method to rapidly assess resistance/susceptibility of Micro-Tom tomatoes to Tomato yellow leaf curl virus via agroinoculation of cotyledons

フルテキストURL	fulltext.pdf
著者	Mori, Tomoaki\| Takenaka, Kosuke\| Domoto, Fumiya\| Aoyama, Yasuhiro\| Sera, Takashi\|
キーワード	Agrobacterium Agroinoculation Cotyledon Micro-Tom Tomato yellow leaf curl virus
発行日	2021-06-23
出版物タイトル	BMC Research Notes
巻	14巻
号	1号
出版者	Springer Nature
開始ページ	237
ISSN	1756-0500
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021.
論文のバージョン	publisher
PubMed ID	34162412
DOI	10.1186/s13104-021-05651-3
Web of Science KeyUT	000667281500002
関連URL	isVersionOf https://doi.org/10.1186/s13104-021-05651-3

Biological Effects of Bioresorbable Materials in Alveolar Ridge Augmentation: Comparison of Early and Slow Resorbing Osteosynthesis Materials

フルテキストURL	fulltext.pdf
著者	Kawai, Hotaka\| Sukegawa, Shintaro\| Nakano, Keisuke\| Takabatake, Kiyofumi\| Ono, Sawako\| Nagatsuka, Hitoshi\| Furuki, Yoshihiko\|
キーワード	poly L-lactic acid uncalcined and unsintered hydroxyapatite polyglycolic acid alveolar ridge augmentation
発行日	2021-06-14
出版物タイトル	Materials
巻	14巻
号	12号
出版者	MDPI
開始ページ	3286
ISSN	1996-1944
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors.
論文のバージョン	publisher
PubMed ID	34198634
DOI	10.3390/ma14123286
Web of Science KeyUT	000665908600001
関連URL	isVersionOf https://doi.org/10.3390/ma14123286

The Fungal Metabolite (+)-Terrein Abrogates Ovariectomy-Induced Bone Loss and Receptor Activator of Nuclear Factor-kappa B Ligand-Induced Osteoclastogenesis by Suppressing Protein Kinase-C alpha/beta II Phosphorylation

フルテキストURL	fulltext.pdf
著者	Sakaida, Kyosuke\| Omori, Kazuhiro\| Nakayama, Masaaki\| Mandai, Hiroki\| Nakagawa, Saki\| Sako, Hidefumi\| Kamei, Chiaki\| Yamamoto, Satoshi\| Kobayashi, Hiroya\| Ishii, Satoki\| Ono, Mitsuaki\| Ibaragi, Soichiro\| Yamashiro, Keisuke\| Yamamoto, Tadashi\| Suga, Seiji\| Takashiba, Shogo\|
キーワード	(+)-terrein ovariectomy osteoporosis RANKL PKC
発行日	2021-06-08
出版物タイトル	Frontiers In Pharmacology
巻	12巻
出版者	Frontiers Media SA
開始ページ	674366
ISSN	1663-9812
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Sakaida, Omori, Nakayama, Mandai, Nakagawa, Sako, Kamei, Yamamoto, Kobayashi, Ishii, Ono, Ibaragi, Yamashiro, Yamamoto, Suga and Takashiba.
論文のバージョン	publisher
PubMed ID	34168561
DOI	10.3389/fphar.2021.674366
Web of Science KeyUT	000664090900001
関連URL	isVersionOf https://doi.org/10.3389/fphar.2021.674366

Presence of Microplastics in Four Types of Shellfish Purchased at Fish Markets in Okayama City, Japan

JaLCDOI	10.18926/AMO/62234
フルテキストURL	75_3_381.pdf
著者	Yamamoto, Ken-ichi\| Oshiki, Toshiyuki\| Kagawa, Hiroko\| Namba, Masayoshi\| Sakaguchi, Masakiyo\|
抄録	The worldwide microplastic pollution in our environment is a matter of great concern. Harmful effects of plastics have been reported in various types of organisms including murine animals. We examined the presence of microplastics in four types of shellfish purchased from fish markets in Okayama, Japan and served to the public: short-neck clam (Ruditapes philippinarum, asari in Japanese), hard-shell clam (Meretrix lusoria, hamaguri), brackishwater clam (Cyrenidae, shijimi), and oyster (Crassostrea gigas, kaki). Our analyses demonstrated that approx. 3 pieces of microplastics were present per single shellfish, based on the division of the total number of pieces of microplastic obtained from all 4 types of shellfish by the total number of shellfish examined. Since health problems in humans due to microplastics have not yet been confirmed, further examinations of the effects of ingested microplastics are needed.
キーワード	microplastics, shellfish Japan health effect pollution
Amo Type	Short Communication
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	381
終了ページ	384
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176943
Web of Science KeyUT	000667147700014
NAID	120007089831

Photoelectric Dye, NK-5962, as a Potential Drug for Preventing Retinal Neurons from Apoptosis: Pharmacokinetic Studies Based on Review of the Evidence

フルテキストURL	fulltext20210623-1.pdf
著者	Matsuo, Toshihiko\| Liu, Shihui\| Uchida, Tetsuya\| Onoue, Satomi\| Nakagawa, Shinsaku\| Ishii, Mayumi\| Kanamitsu, Kayoko\|
キーワード	NK-5962 photoelectric dye apoptosis retinal neuron neuroprotection pharmacokinetics ADME phototoxic/photosensitive assay reactive oxygen species assay photosafety
発行日	2021-6-21
出版物タイトル	Life
巻	11巻
号	6号
出版者	MDPI
開始ページ	591
ISSN	2075-1729
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors
論文のバージョン	publisher
DOI	10.3390/life11060591
NAID	120007089837
関連URL	isVersionOf https://doi.org/10.3390/life11060591

Cellular and transcriptomic analyses reveal two-staged chloroplast biogenesis underpinning photosynthesis build-up in the wheat leaf

フルテキストURL	fulltext.pdf
著者	Loudya, Naresh\| Mishra, Priyanka\| Takahagi, Kotaro\| Uehara-Yamaguchi, Yukiko\| Inoue, Komaki\| Bogre, Laszlo\| Mochida, Keiichi\| Lopez-Juez, Enrique\|
キーワード	Wheat Plastid Chloroplast Leaf development
発行日	2021-05-11
出版物タイトル	Genome Biology
巻	22巻
号	1号
出版者	BMC
ISSN	1474-760X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2021
論文のバージョン	publisher
PubMed ID	33975629
DOI	10.1186/s13059-021-02366-3
NAID	120007053369
Web of Science KeyUT	000656231800003
関連URL	isVersionOf https://doi.org/10.1186/s13059-021-02366-3

Experimental introduction of mycoviruses into phytopathogenic filamentous fungi and their biologic characterization

フルテキストURL	K0006419_abstract_review.pdf K0006419_fulltext.pdf K0006419_summary.pdf
著者	Sabitree, Shahi\|
発行日	2021-03-25
資料タイプ	学位論文
学位授与番号	甲第6419号
学位授与年月日	2021-03-25
学位・専攻分野	博士（農学）
授与大学	岡山大学
言語	英語

Mutant BIN1-Dynamin 2 complexes dysregulate membrane remodeling in the pathogenesis of centronuclear myopathy

フルテキストURL	K0006355_fulltext.pdf K0006355_abstract_review.pdf K0006355_summary.pdf
著者	藤瀬賢志郎\|
発行日	2021-03-25
資料タイプ	学位論文
学位授与番号	甲第6355号
学位授与年月日	2021-03-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語
著作権者	© 2020 THE AUTHORS

Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level

フルテキストURL	K0006346_fulltext.pdf K0006346_abstract_review.pdf K0006346_summary.pdf
著者	友信奈保子\|
発行日	2021-03-25
資料タイプ	学位論文
学位授与番号	甲第6346号
学位授与年月日	2021-03-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語
著作権者	© 2020 The Authors