検索結果 - 岡山大学学術成果リポジトリ

Fabricating small-scale, curved, polymeric structures with convex and concave menisci through interfacial free energy equilibrium

著者	Cheng, Chao-Min\| Matsuura, Koji\| Wang, I-Jan\| Kuroda, Yuka\| LeDuc, Philip R.\| Naruse, Keiji\|
発行日	2009
出版物タイトル	Lab on a Chip
巻	9巻
号	22号
資料タイプ	学術雑誌論文

Improved development of mouse and human embryos using a tilting embryo culture system

著者	Matsuura, Koji\| Hayashi, Nobuyoshi\| Kuroda, Yuka\| Takiue, Chisato\| Hirata, Rei\| Takenami, Mami\| Aoi, Yoko\| Yoshioka, Nanako\| Habara, Toshihiro\| Mukaida, Tetsunori\| Naruse, Keiji\|
発行日	2010-03
出版物タイトル	Reproductive BioMedicine Online
巻	20巻
号	3号
資料タイプ	学術雑誌論文

Esophageal Cancer Initially Thought to be Accompanied by a Solitary Metastasis to an Intrathoracic Paraaortic Lymph Node

JaLCDOI	10.18926/AMO/48966
フルテキストURL	66_5_417.pdf
著者	Horio, Takuya\| Ogata, Sho\| Tsujimoto, Hironori\| Akase, Takayoshi\| Takahata, Risa\| Yaguchi, Yoshihisa\| Maehara, Tadaaki\| Hase, Kazuo\|
抄録	Esophageal cancers usually exhibit lymph-node metastases. Although a solitary lymph-node metastasis is occasionally found, the involvement of an intrathoracic paraaortic node is rare. We present here an intrathoracic mid-esophageal cancer case in which an accompanying solitary retroaortic mass was found within the posterior mediastinum by integrated positron emission tomography/computed tomography. For diagnosis, thoracoscopic resection of the mass was performed from a left thoracic approach, and histology revealed it to be a squamous cell carcinoma metastasized from the esophageal cancer. Upon radical esophagectomy after neoadjuvant therapy as a T3N1M0 Stage IIIa (AJCC/UICC) cancer, the esophageal cancer was found to have invaded unexpectedly deeply in the vicinity of the descending aorta. Another lymph node within the paraaortic region was also involved (T4N1M0 Stage IIIc). The present case and other cases we review here inform our understanding of metastasis to intrathoracic paraaortic nodes as follows:1) its existence may indicate extensive lymph-node metastasis or direct tumor invasion nearby, and 2) it may be accompanied by other lymph-node involvements in this region, even if it appears solitary upon preoperative investigation. Thus, for radical esophagectomy, sufficient lymph-node dissection is required, even at locations not reached by the usual right thoracic approach. Definitive chemoradiotherapy may be a better choice for preoperatively recognized T3 esophageal cancer when the cancer is accompanied by paraaortic lymph node metastasis.
キーワード	esophageal cancer intrathoracic paraaortic lymph node solitary metastasis
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2012-10
巻	66巻
号	5号
出版者	Okayama University Medical School
開始ページ	417
終了ページ	421
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23093060
Web of Science KeyUT	000310253900006

HIF-1α Contributes to Hypoxia-induced Invasion and Metastasis of Esophageal Carcinoma via Inhibiting E-cadherin and Promoting MMP-2 Expression

JaLCDOI	10.18926/AMO/48964
フルテキストURL	66_5_399.pdf
著者	Jing, Shao-Wu\| Wang, Ya-Di\| Kuroda, Masahiro\| Su, Jing-Wei\| Sun, Guo-Gui\| Liu, Qing\| Cheng, Yun-Jie\| Yang, Cong-Rong\|
抄録	Hypoxia-inducible factor-1α (HIF-1α) has been found to enhance tumor invasion and metastasis, but no study has reported its action in esophageal carcinoma. The goal of this study was to explore the probable mechanism of HIF-1α in the invasion and metastasis of esophageal carcinoma Eca109 cells in vitro and in vivo. mRNA and protein expression of HIF-1α, E-cadherin and matrix metalloproteinase-2 (MMP-2) under hypoxia were detected by RT-PCR and Western blotting. The effects of silencing HIF-1α on E-cadherin, MMP-2 mRNA and protein expression under hypoxia or normoxia were detected by RT-PCR and Western blotting, respectively. The invasive ability of Eca109 cells was tested using a transwell chambers. We established an Eca109-implanted tumor model and observed tumor growth and lymph node metastasis. The expression of HIF-1α, E-cadherin and MMP-2 in xenograft tumors was detected by Western blotting. After exposure to hypoxia, HIF-1α protein was up-regulated, both mRNA and protein levels of E-cadherin were down-regulated and MMP-2 was up-regulated, while HIF-1α mRNA showed no significant change. SiRNA could block HIF-1α effectively, increase E-cadherin expression and inhibit MMP-2 expression. The number of invading cells decreased after HIF-1α was silenced. Meanwhile, the tumor volume was much smaller, and the metastatic rate of lymph nodes and the positive rate were lower in vivo. Our observations suggest that HIF-1α inhibition might be an effective strategy to weaken invasion and metastasis in the esophageal carcinoma Eca109 cell line.
キーワード	hypoxia-inducible factor-1α esophageal carcinoma invasion and metastasis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2012-10
巻	66巻
号	5号
出版者	Okayama University Medical School
開始ページ	399
終了ページ	407
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23093058
Web of Science KeyUT	000310253900004

The Therapeutic Potential of Human Umbilical Cord Blood Transplantation for Neonatal Hypoxic-Ischemic Brain Injury and Ischemic Stroke

JaLCDOI	10.18926/AMO/48962
フルテキストURL	66_6_429.pdf
著者	Wang, Feifei\| Maeda, Nagamasa\| Yasuhara, Takao\| Kameda, Masahiro\| Tsuru, Emi\| Yamashita, Tatsuyuki\| Shen, Yuan\| Tsuda, Masayuki\| Date, Isao\| Sagara, Yusuke\|
抄録	Human umbilical cord blood (HUCB) cells are rich source of immature stem cells, which have the potential to repair lost tissue. Intractable central nervous system (CNS) disorders are important targets for regenerative medicine, and the application of HUCB cells is being investigated in animal models of CNS disorders. Transplantation of HUCB has induced functional improvements in these animal models due to multiple therapeutic effects including neuroprotection, anti-inflammation, angiogenesis, and neurogenesis. HUCB cells are easily available and safer than other stem cells used in transplantation therapy. In this review, we focus on HUCB transplantation as an encouraging therapeutic approach for animal models of neonatal hypoxic-ischemic brain injury and ischemic stroke.
キーワード	umbilical cord blood cell transplantation neonatal hypoxic-ischemic brain injury ischemic stroke stem cells
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2012-12
巻	66巻
号	6号
出版者	Okayama University Medical School
開始ページ	429
終了ページ	434
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23254576
Web of Science KeyUT	000312966100001

Miniature Pneumatic Curling Rubber Actuator Generating Bidirectional Motion with One Air-Supply Tube

著者	Wakimoto, Shuichi\| Suzumori, Koichi\| Ogura, Keiko\|
発行日	2011
出版物タイトル	Advanced Robotics
巻	25巻
号	9-10号
資料タイプ	学術雑誌論文

Expression of ALDH1 in axillary lymph node metastases is a prognostic factor of poor clinical outcome in breast cancer patients with 1–3 lymph node metastases

著者	Nogami, Tomohiro\| Shien, Tadahiko\| Tanaka, Takehiro\| Nishiyama, Keiko\| Mizoo, Taeko\| Iwamto, Takayuki\| Ikeda, Hirokuni\| Taira, Naruto\| Doihara, Hiroyoshi\| Miyoshi, Shinichiro\|
発行日	2012-03-10
出版物タイトル	Breast Cancer
資料タイプ	学術雑誌論文

Galectin-9 and T Cell Immunoglobulin Mucin-3 Pathway Is a Therapeutic Target fot Type 1 Diabetes

著者	神崎資子\|
発行日	2012-06-30
出版物タイトル
資料タイプ	学位論文

Germinal center B-cell-like versus non-germinal center B-cell-like as important prognostic factors for localized nodal DLBCL

著者	羽原利幸\|
発行日	2012-06-30
出版物タイトル
資料タイプ	学位論文

Lentivirus-based Gene Delivery in Mouse Embryonic Stem Cells

著者	小坂芳和\|
発行日	2012-06-30
出版物タイトル
資料タイプ	学位論文

Down-regulation of BiP/GRP78 sensitizes resistant prostate cancer cells to gene-therapeutic overexpression of REIC/Dkk-3

著者	Tanimoto, Ryuta\| Sakaguchi, Masakiyo\| Abarzua, Fernando\| Kataoka, Ken\| Kurose, Kaoru\| Murata, Hitoshi\| Nasu, Yasutomo\| Kumon, Hiromi\| Huh, Nam-Ho\|
発行日	2010-04-01
出版物タイトル	International Journal of Cancer
巻	126巻
号	7号
資料タイプ	学術雑誌論文

Potent antitumor effects of combined therapy with a telomerase-specific, replication-competent adenovirus (OBP-301) and IL-2 in a mouse model of renal cell carcinoma

著者	Huang, P\| Kaku, H\| Chen, J\| Kashiwakura, Y\| Saika, T\| Nasu, Y\| Urata, Y\| Fujiwara, T\| Watanabe, M\| Kumon, H\|
発行日	2010-07
出版物タイトル	Cancer Gene Therapy
巻	17巻
号	7号
資料タイプ	学術雑誌論文

Overexpression of REIC/Dkk-3 in Normal Fibroblasts Suppresses Tumor Growth via Induction of Interleukin-7

著者	Sakaguchi, Masakiyo\| Kataoka, Ken\| Abarzua, Fernando\| Tanimoto, Ryuta\| Watanabe, Masami\| Murata, Hitoshi\| Than, Swe Swe\| Kurose, Kaoru\| Kashiwakura, Yuji\| Ochiai, Kazuhiko\| Nasu, Yasutomo\| Kumon, Hiromi\| Huh, Nam-ho\|
発行日	2009-05-22
出版物タイトル	The Journal of Biological Chemistry
巻	284巻
号	21号
資料タイプ	学術雑誌論文

A simple biological imaging system for detecting viable human circulating tumor cells

著者	Kojima, Toru\| Hashimoto, Yuuri\| Watanabe, Yuichi\| Kagawa, Shunsuke\| Uno, Futoshi\| Kuroda, Shinji\| Tazawa, Hiroshi\| Kyo, Satoru\| Mizuguchi, Hiroyuki\| Urata, Yasuo\| Tanaka, Noriaki\| Fujiwara, Toshiyoshi\|
発行日	2009-10-01
出版物タイトル	The Journal of Clinical Investigation
巻	119巻
号	10号
資料タイプ	学術雑誌論文

TRAPPC9 Mediates the Interaction between p150<sup>Glued</sup> and COPII Vesicles at the Target Membrane

著者	Zong, Min\| Satoh, Ayano\| Yu, Mei Kuen\| Siu, Ka Yu\| Ng, Wing Yan\| Chaｎ, Hsiao Chang\| Tanner, Julian A.\| Yu, Sidney\|
発行日	2012-01-18
出版物タイトル	PLoS ONE
巻	7巻
号	1号
資料タイプ	学術雑誌論文

mTrs130 Is a Component of a Mammalian TRAPPII Complex, a Rab1 GEF That Binds to COPI-coated Vesicles

著者	Yamasaki, Akinori\| Menon, Shekar\| Yu, Sidney\| Barrowman, Jemima\| Meerloo, Timo\| Oorschot, Viola\| Klumperman, Judith\| Satoh, Ayano\| Ferro-Novick, Susan\|
発行日	2009-10-01
出版物タイトル	Molecular Biology of the Cell
巻	20巻
号	19号
資料タイプ	学術雑誌論文

A chemical biology approach reveals an opposite action between thermospermine and auxin in xylem development in Arabidopsis thaliana

著者	Yoshimoto, Kaori\| Noutoshi, Yoshiteru\| Hayashi, Ken-ichiro\| Shirasu, Ken\| Takahashi, Taku\| Motose, Hiroyasu\|
発行日	2012-04
出版物タイトル	Plant and Cell Physiology
巻	53巻
号	4号
資料タイプ	学術雑誌論文

No Different Sensitivity in Terms of Whole-Body Irradiation between Normal and Acatalasemic Mice

著者	Nakagawa, Shinya\| Kataoka, Takahiro\| Mizuguchi, Yuko\| Yoshimoto, Masaaki\| Sakoda, Akihiro\| Nomura, Takaharu\| Wang, Da-Hong\| Kawabe, Atsushi\| Taguchi, Takehito\| Yamaoka, Kiyonori\|
発行日	2008-07
出版物タイトル	Journal of Clinical Biochemistry and Nutrition
巻	43巻
号	1号
資料タイプ	学術雑誌論文

The Elevation of p53 Protein Level and SOD Activity in the Resident Blood of the Misasa Radon Hot Spring District

著者	Yamaoka, Kiyonori\| Mitsunobu, Fumihiro\| Kojima, Shuji\| Shibakura, Misako\| Kataoka, Takahiro\| Hanamoto, Katsumi\| Tanizaki, Yoshiro\|
発行日	2005-04-01
出版物タイトル	Journal of Radiation Research
巻	46巻
号	1号
資料タイプ	学術雑誌論文

Structural and functional studies on Ycf12 (Psb30) and PsbZ-deletion mutants from a thermophilic cyanobacterium

著者	Takasaka, Kenji\| Iwai, Masako\| Umena, Yasufumi\| Kawakami, Keisuke\| Ohmori, Yukari\| Ikeuchi, Masahiko\| Takahashi, Yuichiro\| Kamiya, Nobuo\| Shen, Jian-Ren\|
発行日	2010-02
出版物タイトル	Biochimica et Biophysica Acta (BBA) - Bioenergetics
巻	1797巻
号	2号
資料タイプ	学術雑誌論文