| ID | 65538 |
| フルテキストURL | |
| 著者 |
Hirai, Ryosuke
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Hirai, Mami
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
Otsuka, Motoyuki
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Mitsuhashi, Toshiharu
Center for Innovative Clinical Medicine, Okayama University Hospital
Shimodate, Yuichi
Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
Mouri, Hirokazu
Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
Matsueda, Kazuhiro
Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
Yamamoto, Hiroshi
Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
Mizuno, Motowo
Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
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| 抄録 | Background We previously demonstrated that the Kyoto classification of gastritis was useful for judging the status of Helicobacter pylori infection in a population-based screening program, and that adding H. pylori antibody test improved its accuracy (UMIN000028629). Here, we tested whether our endoscopic diagnosis of H. pylori infection status reliably estimated gastric cancer risk in the program.
Methods Data were collected from1345 subjects who underwent endoscopic follow-up 4 years after the end of the registration. We analyzed the association of three diagnostic methods of H. pylori infection with gastric cancer detection: (1) endoscopic diagnosis based on the Kyoto classification of gastritis; (2) serum diagnosis according to the ABC method (H. pylori antibody and pepsinogen I and II); and (3) endoscopic diagnosis together with H. pylori antibody test. Results During the follow-up, 19 cases of gastric cancer were detected. By Kaplan–Meier analysis, the detection rates of cancer were significantly higher in the past or current H. pylori infection groups than in the never-infected group with all 3 methods. By the Cox proportional hazards model, the hazard ratio for cancer detection was highest in evaluation with the combined endoscopic diagnosis and the antibody test (method 3; hazard ratio 22.6, 95% confidence interval 2.99–171) among the three methods (the endoscopic diagnosis (method 1); 11.3, 2.58–49.8, and the ABC method (method 2); 7.52, 2.49–22.7). Conclusions Endoscopic evaluation of H. pylori status with the Kyoto classification of gastritis, especially combined with serum anti-Helicobacter pylori antibody testing, reliably risk-stratified subjects in a population-based gastric cancer screening program. |
| キーワード | Cancer screening
Gastric cancer
Helicobacter pylori
Gastrointestinal endoscopy
Atrophic gastritis
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| 備考 | The version of record of this article, first published in Journal of Gastroenterology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00535-023-02010-w
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| 発行日 | 2023-06-21
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| 出版物タイトル |
Journal of Gastroenterology
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| 巻 | 58巻
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| 号 | 9号
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| 出版者 | Springer Science and Business Media LLC
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| 開始ページ | 848
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| 終了ページ | 855
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| ISSN | 0944-1174
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| 資料タイプ |
学術雑誌論文
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| 言語 |
英語
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| OAI-PMH Set |
岡山大学
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| 著作権者 | © The Author(s) 2023
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| 論文のバージョン | publisher
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| PubMed ID | |
| DOI | |
| Web of Science KeyUT | |
| 関連URL | isVersionOf https://doi.org/10.1007/s00535-023-02010-w
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| ライセンス | http://creativecommons.org/licenses/by/4.0/
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| Citation | Hirai, R., Hirai, M., Otsuka, M. et al. Endoscopic evaluation by the Kyoto classification of gastritis combined with serum anti-Helicobacter pylori antibody testing reliably risk-stratifies subjects in a population-based gastric cancer screening program. J Gastroenterol 58, 848–855 (2023). https://doi.org/10.1007/s00535-023-02010-w
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