検索結果 14069 件
| 著者 | 那須 保友| |
|---|---|
| 発行日 | 2011-08-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 123巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 西丸 和義| |
|---|---|
| 発行日 | 1928-07-31 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 40巻 |
| 号 | 7号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 河村 九十九| |
|---|---|
| 発行日 | 1928-06-30 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 40巻 |
| 号 | 6号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 田中 龜| |
|---|---|
| 発行日 | 1928-04-30 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 40巻 |
| 号 | 4号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 大谷 顯三| |
|---|---|
| 発行日 | 1928-04-30 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 40巻 |
| 号 | 4号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 田中 龜| |
|---|---|
| 発行日 | 1928-03-31 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 40巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 高橋 昌造| |
|---|---|
| 発行日 | 1929-12-31 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 41巻 |
| 号 | 12号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/46633 |
|---|---|
| フルテキストURL | 65_3_205.pdf |
| 著者 | Akavipat, Phuping| Sookplung, Pimwan| Kaewsingha, Pranee| Maunsaiyat, Patcharin| |
| 抄録 | To identify the diagnostic properties of the Full Outline of Unresponsiveness (FOUR) score and the discharge outcome, 318 patients were studied. The evaluators rated the patients on admission or when they had mental status alteration with the FOUR score. The course of treatment was determined based on the clinical. The mortality rate and Glasgow Outcome Scale were recorded. Adjusted regression models and prognostic performance were tested by calculation of the receiver operating characteristic curve. One-hundred and twenty-two patients (40.1%) had a poor outcome defined as a Glasgow Outcome Scale score from 3-5, and 38 patients (12.5%) died. The area under the characteristic curve (AUC) for poor outcome and in-hospital mortality were 0.88 (95% CI, 0.83-0.92) and 0.92 (95% CI, 0.87-0.97). The cut-off point of 14 showed sensitivity and specificity of the total FOUR score predicting poor outcomes at 0.77 (95% CI, 0.69-0.84) and 0.95 (95% CI, 0.90-0.97), while the cut-off point of 10 showed the values for in-hospital mortality at 0.71 (95% CI, 0.55-0.83) and 0.93 (95% CI, 0.90-0.96). The total FOUR score showed satisfactory prognostic value for predicting outcome. The cut-off points for the poor outcome and in-hospital mortality are 14 and 10, respectively. |
| キーワード | consciousness evaluation mortality outcome Full Outline of Unresponsiveness (FOUR) |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-06 |
| 巻 | 65巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 205 |
| 終了ページ | 210 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 21709719 |
| Web of Science KeyUT | 000292017500008 |
| JaLCDOI | 10.18926/AMO/46631 |
|---|---|
| フルテキストURL | 65_3_193.pdf |
| 著者 | Kawaura, Akihiko| Tanida, Noritoshi| Akiyama, Junichi| Nonaka, Kouji| Mizutani, Masatoshi| Sawada, Kenji| Nakagawa, Kimie| Tsugawa, Naoko| Izumi, Keisuke| Ii, Kunio| Okano, Toshio| Takeda, Eiji| |
| 抄録 | Sixty-three male 5-week-old Syrian hamsters received the carcinogen N-nitrosobis(2-oxopropyl)amine (BOP) s.c. in 5 weekly injections (the first, 70mg/kg body, and the remaining, 20mg/kg each). The hamsters that received BOP were given intragastric administration of 0.2ml of medium chain triglyceride (MCT) with or without 0.04μg of 1α-hydroxyvitamin D3 [1α(OH)D3] through a feeding tube for 12 weeks. Thus, 3 groups were assigned:Group 1;BOP alone (n＝20), Group 2;BOP＋MCT (n＝18) and Group 3;BOP＋1α(OH)D3 (n＝25). The mean body weight of Group 3 was lower than those of Groups 1 and 2 at the end of the experiment (p＜0.001,Tukey-Kramer HSD test). At the end of week 12, all surviving hamsters were put to sleep. The incidences of liver tumors were 80%, 72% and 32% in Groups 1, 2 and 3, respectively. The incidence of tumors in Group 3 was significantly lower than in Group 1 and Group 2 (p＜0.05, χ2-test). All tumors were cholangiocarcinoma. These results indicated that BOP-induced cholangiocarcinogenesis was suppressed by the supplemental administration of 1α(OH)D3. |
| キーワード | 1α-hydroxyvitamin D3 N-nitrosobis(2-oxopropyl)amine cholangiocarcinogenesis Syrian hamsters |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-06 |
| 巻 | 65巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 193 |
| 終了ページ | 197 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 21709717 |
| Web of Science KeyUT | 000292017500006 |
| JaLCDOI | 10.18926/AMO/46628 |
|---|---|
| フルテキストURL | 65_3_169.pdf |
| 著者 | Takeda, Masanori| Nagasaka, Takeshi| Dong-Sheng, Sun| Nishie, Hiroyuki| Oka, Tetsuhiro| Yamada, Eiji| Mori, Yoshiko| Shigeyasu, Kunitoshi| Morikawa, Tatsuya| Mizobuchi, Satoshi| Fujiwara, Toshiyoshi| |
| 抄録 | Secreted frizzled-related protein 2, (SFRP2) is a Wnt inhibitor whose promoter CpGs were recently found to be methylated at high frequency in colorectal cancers (CRCs). We hypothesized that the pattern of SFRP2 methylation may differ throughout the promoter during progressive tumorigenesis. Using combined bisulfite restriction analysis (COBRA), two methylation-sensitive regions (Regions A and B) of the SFRP2 promoter were investigated in 569 specimens of colorectal tissue:222 CRCs, 103 adenomatous polyps (APs), 208 normal colonic mucosa from CRC patients (N-Cs), and 36 normal colonic mucosa from subjects with no evidence of colorectal neoplasia at colonoscopy (N-Ns). Extensive (including both Regions A and B) and partial (either Region A or B) SFRP2 methylation levels were found in 61.7% and 24.8% of CRCs, 8.7% and 37.9% of APs, 3.9% and 39.9% of N-Cs, and 0% and 30.6% of N-Ns, respectively. Extensive methylation of the SFRP2 promoter was present primarily in CRCs, while partial methylation was common in APs. Whereas APs with the KRAS mutant showed no correlation to any pattern of SFRP2 methylation, extensive methylation of the SFRP2 promoter was significantly associated with KRAS mutant CRCs (p＜.0001), suggesting that genetic alteration in the RAS-RAF pathway might precede the spread of CpG methylation through the SFRP2 promoter, which is observed in over 60% of advanced colorectal tumors. |
| キーワード | BRAF/KRAS mutations promoter methylation colorectal cancer |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-06 |
| 巻 | 65巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 169 |
| 終了ページ | 177 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 21709714 |
| Web of Science KeyUT | 000292017500003 |
| JaLCDOI | 10.18926/AMO/46627 |
|---|---|
| フルテキストURL | 65_3_163.pdf |
| 著者 | Arai, Minako| Takata, Ken| Takeda, Yoshimasa| Mizobuchi, Satoshi| Morita, Kiyoshi| |
| 抄録 | The mechanism of oxygen toxicity for central nervous system and hyperbaric oxygen (HBO) seizure has not been clarified. Noradrenergic cells in the brain may contribute to HBO seizure. In this study, we defined the activation of noradrenergic cells during HBO exposure by c-fos immunohistochemistry. Electroencephalogram electrodes were pre-implanted in all animals under general anesthesia. In HBO seizure animals, HBO was induced with 5 atm of 100% oxygen until manifestation of general tonic convulsion. HBO non-seizure animals were exposed to 25 min of HBO. Control animals were put in the chamber for 120 min without pressurization. All animals were processed for c-fos immunohistochemical staining. All animals in the HBO seizure group showed electrical discharge on EEG. In the immunohistochemistry, c-fos was increased in the A1, A2 and A6 cells of the HBO seizure group, and in the A2 and A6 cells of the HBO non-seizure group, yet was extremely low in all three cell types in the control group. These results suggest the participation of noradrenaline in HBO seizure, which can be explained by the early excitement of A1 cells due to their higher sensitivity to high blood pressure, hyperoxia, or by the post-seizure activation of all noradrenergic cells. |
| キーワード | hyperbaric oxygen seizure noradrenergic cells immunohistochemistry |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-06 |
| 巻 | 65巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 163 |
| 終了ページ | 168 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 21709713 |
| Web of Science KeyUT | 000292017500002 |
| 著者 | 高橋 昌造| |
|---|---|
| 発行日 | 1929-07-31 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 41巻 |
| 号 | 7号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 石田 展久| |
|---|---|
| 発行日 | 2011-03-25 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 柳 文修| |
|---|---|
| 発行日 | 2011-03-25 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 神野 透人| |
|---|---|
| 発行日 | 2011-03-25 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 譚 東| |
|---|---|
| 発行日 | 2011-03-25 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 酒見 由美| |
|---|---|
| 発行日 | 2011-03-25 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 小林 泰之| |
|---|---|
| 発行日 | 2011-03-25 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 杜 剛| |
|---|---|
| 発行日 | 2011-03-25 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 吉尾 浩太郎| |
|---|---|
| 発行日 | 2011-03-25 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |