腹腔内癒着防止に関する実験的研究

Preventing effect of several chemical substances to the peritoneal adhesion was examined both anatomically and histologicaily following intraperitoneal administration of the substances to the site of artifical defect made on the serous membrane of the stomach, instestine and the parietal peritoneum. The results are as follows: (1) In the preliminary study, it was confirmed that the serous defect of 1.0 cm×2.0 cm square was enough to make an extensive adhesion without any chemical irritation to the peritoneum when no adhesion-preventing substances were applied. This size of defect was used as the control of the experiment throughout the study. (2) Infusion of a large quantity of physiologic saline solution to the peritoneal cavity at the time of closing the cavity showed remarkable preventing effect of the adhesion. Improvement of the effect was seen by supplementary subcutaneous administration of the fluid in addition to this procedure. Supplementary peritoneal infusion of the fluid with vinyl tube made no improvement. (3) There was some preventing action seen with infusion of the nitromine, trypsine and varidase solution although less effective than the saline solution mentioned above. (4) The serous defect was completely coated with the cover cells of the serous membrane after 5 days in case of saline solution being infused. It took 7 days to repair the defect when the other three substances were applied as well as the control experiment in which no chemical substances were used. The parietal peritoneum showed much slower recovery, 7 days for the saline solution and 10 days for the other substances as well as the control experiment.