検索結果 - 岡山大学学術成果リポジトリ

A Novel Molecular Therapy Using Bioengineered Adenovirus for Human Gastrointestinal Cancer

JaLCDOI	10.18926/AMO/46626
フルテキストURL	65_3_151.pdf
著者	Fujiwara, Toshiyoshi\|
抄録	Replication-selective tumor-specific viruses constitute a novel approach for treatment of neoplastic disease. These vectors are designed to induce virus-mediated lysis of tumor cells after selective viral propagation within the tumor. Human telomerase is highly active in more than 85ｵ of primary cancers, regardless of their tissue origins, and its activity correlates closely with human telomerase reverse transcriptase (hTERT) expression. We constructed an attenuated adenovirus 5 vector (Telomelysin, OBP-301), in which the hTERT promoter element drives expression of E1 genes. Since only tumor cells that express telomerase activity would activate this promoter, the hTERT proximal promoter would allow for preferential expression of viral genes in tumor cells, leading to selective viral replication and oncolytic cell death. Lymphatic invasion is a major route for cancer cell dissemination, and adequate treatment of locoregional lymph nodes is required for curative treatment in patients with gastrointestinal tumors. We demonstrated that intratumoral injection of Telomelysin mediates effective in vivo purging of metastatic tumor cells from regional lymph nodes. Moreover, using noninvasive whole-body imaging, we found that intratumoral injection of Telomelysin followed by regional irradiation induces a substantial antitumor effect, resulting from tumor cell-specific radiosensitization, in an orthotopic human esophageal cancer xenograft model. These results illustrate the potential of oncolytic virotherapy as a promising strategy in the management of human gastrointestinal cancer.
キーワード	telomerase adenovirus metastasis lymph node colorectal cancer
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2011-06
巻	65巻
号	3号
出版者	Okayama University Medical School
開始ページ	151
終了ページ	162
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	21709712
Web of Science KeyUT	000292017500001

Urinary 8-OHdG elevations in a partial lesion rat model of Parkinson's disease correlate with behavioral symptoms and nigrostriatal dopaminergic depletion

著者	菊池陽一郎\|
発行日	2011-03-25
出版物タイトル
資料タイプ	学位論文

Infusion of Hypertonic Saline into the Lung Parenchyma during Radiofrequency Ablation of the Lungs with Multitined Expandable Electrodes: Results Using a Porcine Model

著者	井石龍比古\|
発行日	2011-03-25
出版物タイトル
資料タイプ	学位論文

Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: Focusing on neuroprotective effects of stromal cell-derived factor-1α

著者	王飛霏\|
発行日	2011-03-25
出版物タイトル
資料タイプ	学位論文

Analysis of the Factors That Affect Dental Health Behaviour and Attendance at Scheduled Dental Check-ups Using the PRECEDE-PROCEED Model

著者	佐藤公子\|
発行日	2011-03-25
出版物タイトル
資料タイプ	学位論文

線虫C.エレガンスの遺伝子と遺伝子の虫

著者	香川弘昭\|
発行日	2010-05
出版物タイトル	岡山実験動物研究会報
巻	26巻
資料タイプ	その他

兩棲類心臟原基發生ニ關スル研究補遺

著者	吉田豐太\|
発行日	1932-12-31
出版物タイトル	岡山医学会雑誌
巻	44巻
号	12号
資料タイプ	学術雑誌論文

本邦産蟾蜍ニ於ケル腦板ノ發生ヨリ腦管ノ閉塞ニ至ル迄ノ發生學的竝ニ形態學的研究

著者	香川卓二\|
発行日	1932-07-31
出版物タイトル	岡山医学会雑誌
巻	44巻
号	7号
資料タイプ	学術雑誌論文

肺靜脉ノ發生ニ就キテ（鳥類，特ニ十姉妹ニ於ケル檢索）

著者	吉田豐太\|
発行日	1932-02-29
出版物タイトル	岡山医学会雑誌
巻	44巻
号	2号
資料タイプ	学術雑誌論文

心臟原基ノ發生ニ關スル研究其ノ2（哺乳類特ニ豚胎兒ニ於ケル房間障ノ形成ニ就キテ）

著者	吉田豐太\|
発行日	1932-02-29
出版物タイトル	岡山医学会雑誌
巻	44巻
号	2号
資料タイプ	学術雑誌論文

脾臟原基ノ發生ニ關スル研究（鳥類. 特ニ家鳩ニ於ケル檢索）

著者	富岡諒一\|
発行日	1933-02-28
出版物タイトル	岡山医学会雑誌
巻	45巻
号	2号
資料タイプ	学術雑誌論文

肺臓原基ノ形態學的發生ニ就テ（鳥類殊ニ十姉妹ニ於ケル檢索）

著者	金岡英雄\|
発行日	1934-10-31
出版物タイトル	岡山医学会雑誌
巻	46巻
号	10号
資料タイプ	学術雑誌論文

腦原基ノ形態學的發生ニ關スル研究第1報（鳥類殊ニ十姉妹ニ於ケル檢索）

著者	河内武\|
発行日	1934-09-30
出版物タイトル	岡山医学会雑誌
巻	46巻
号	9号
資料タイプ	学術雑誌論文

膀胱ノ發生ニ就テ家兎胎兒ニ於ケル檢索

著者	大藤利治\|
発行日	1935-12-31
出版物タイトル	岡山医学会雑誌
巻	47巻
号	12号
資料タイプ	学術雑誌論文

無尾兩棲類腦下垂體ノ發生ニ就テ（特ニ青蛙Rhacophorus schlegeliiニ於ケル檢索）

著者	河内武\|
発行日	1935-10-31
出版物タイトル	岡山医学会雑誌
巻	47巻
号	10号
資料タイプ	学術雑誌論文

日本人胎兒喉頭ノ形態學的發生竝ニ其ノ組織學的研究

著者	水野文次郎\|
発行日	1936-02-29
出版物タイトル	岡山医学会雑誌
巻	48巻
号	2号
資料タイプ	学術雑誌論文

For Vol. 64, No. 1 pp 27-31 Prognostic Factors Influencing Survival after ephroureterectomy for Transitional Cell Carcinoma of the Upper Urinary Tract

JaLCDOI	10.18926/AMO/45274
フルテキストURL	65_2_143.pdf
著者	Kobayashi, Yasuyuki\| Saika, Takashi\| Manabe, Daisuke\| Nasu, Yasutomo\| Kumon, Hiromi\|
抄録	We analyzed the prognostic factors influencing survival after surgeries for upper urinary tract urothelial carcinoma (UUT-UC) with longer follow-up periods than in previous studies. Between January 2000 and December 2004, 386 patients underwent nephroureterectomy for UUT-UC. The data for the 221 patients with UUT-UC were retrospectively reviewed. Nine variables were evaluated for association with the survival outcomes of cause-specific survival. The prognostic significance was tested univariately with the log-rank test. The simultaneous effects of multiple prognostic factors were estimated by multiple regression analysis using the Cox proportional hazards model. The median follow-up was 38.4 months. The 5-year over all survival was 62.3%. Significant prognostic factors for disease-specific survival rate on univariate analysis were pathological stage (p0.0001), tumor grade (p0.0324), and venous invasion (p0.0001). Multivariate analysis revealed that only venous invasion was significant for disease-specific survival rate (p0.0205). Venous invasion was the only independent prognostic factor in pathologically localized UUT-UC.
キーワード	nephroureterectomy transitional cell carcinoma upper urinary tract
Amo Type	Corrected and Republished Article
出版物タイトル	Acta Medica Okayama
発行日	2011-04
巻	65巻
号	2号
出版者	Okayama University Medical School
開始ページ	143
終了ページ	149
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	20200581
Web of Science KeyUT	000289818800011

The Macrophage Is a Key Factor in Renal Injuries Caused by Glomerular Hyperfiltration

JaLCDOI	10.18926/AMO/45266
フルテキストURL	65_2_81.pdf
著者	Sasaki, Motofumi\| Shikata, Kenichi\| Okada, Shinichi\| Miyamoto, Satoshi\| Nishishita, Shingo\| Usui Kataoka, Hitomi\| Sato, Chikage\| Wada, Jun\| Ogawa, Daisuke\| Makino, Hirofumi\|
抄録	Glomerular hyperfiltration is a common pathway leading to glomerulosclerosis in various kinds of kidney diseases. The 5/6 renal ablation is an established experimental animal model for glomerular hyperfiltration. On the other hand, low-grade inflammation is also a common mechanism for the progression of kidney diseases including diabetic nephropathy and atherosclerosis. Here we analyzed the gene expression profile in the remnant kidney tissues of 5/6 nephrectomized mice using a DNA microarray system and compared it with that of sham-operated control mice. The 5/6 nephrectomized mice showed glomerular hypertrophy and an increase in the extracellular matrix in the glomeruli. DNA microarray analysis indicated the up-regulated expression of various kinds of genes related to the inflammatory process in remnant kidneys. We confirmed the up-regulated expression of platelet factor-4, and monocyte chemoattractant protein-1, 2, and 5 in remnant kidneys by RT-PCR. The current results suggest that the inflammatory process is involved in the progression of glomerulosclerosis and is a common pathway of the pathogenesis of kidney disease.
キーワード	kidney inflammation chemokine
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2011-04
巻	65巻
号	2号
出版者	Okayama University Medical School
開始ページ	81
終了ページ	89
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	21519365
Web of Science KeyUT	000289818800003

Analysis of the Factors That Affect Dental Health Behaviour and Attendance at Scheduled Dental Check-ups Using the PRECEDE-PROCEED Model

JaLCDOI	10.18926/AMO/45265
フルテキストURL	65_2_71.pdf
著者	Sato, Kimiko\| Oda, Megumi\|
抄録	A questionnaire survey was administered to 317 parents who attended infant health check-ups in City B, Okayama Prefecture between October, 2008 and March, 2009. The questionnaire survey studied 7 factors based on the PRECEDE-PROCEED Model. We analysed factors that affected oral health behaviour and attendance at scheduled dental health check-ups. The survey containing 22 items concerning matters such as 'QOL' and 'health problems' was posted to parents and guardians in advance, and then collected on the day of the medical check-up. The collected data was analysed using the t-test and Pearson's correlation coefficient, following which we conducted a covariance structure analysis. The results showed that dental health behaviour was directly affected by reinforcing factors, and indirectly associated with enabling and predisposing factors influenced by reinforcing factors. It was also shown that predisposing factors and oral health behaviour were associated with attendance at scheduled oral health check-ups. The results indicated that strengthening oral health education by sharing knowledge that acts as predisposing factors and introducing adaptations of oral health behaviour that that fit individual lives will lead to improved attendance at scheduled dental health check-ups.
キーワード	PRECEDE-PROCEED model dental check-ups dental health behaviour
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2011-04
巻	65巻
号	2号
出版者	Okayama University Medical School
開始ページ	71
終了ページ	80
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	21519364
Web of Science KeyUT	000289818800002

日本産「カブトガニ」Tachypleus tridentatusノ心臟ノ解剖學的竝ニ組織學的觀察

著者	河内武\|
発行日	1935-04-30
出版物タイトル	岡山医学会雑誌
巻	47巻
号	4号
資料タイプ	学術雑誌論文