検索結果 - 岡山大学学術成果リポジトリ

Enrichment of Foxp3+ CD4 Regulatory T Cells in Migrated T Cells to IL-6- and IL-8-Expressing Tumors through Predominant Induction of CXCR1 by IL-6

著者	榮川伸吾\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

Hydroa vacciniforme is associated with increased numbers of Epstein-Barr virus-infected γδ T-cells

著者	平井陽至\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

The mechanical stimulation of cells in 3D culture within a self-assembling peptide hydrogel

著者	永井祐介\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

Hepatic Differentiation of Mouse iPS Cells In Vitro

著者	岩室雅也\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

Functional interaction of fibroblast growth factor-8, bone morphogenetic protein and estrogen receptor in breast cancer cell proliferation

著者	増田紘子\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

Different responses to 5-fluoraouracil in mutagenicity and gene expression between two human lymphoblastoid cell lines with or without TP53 mutation

著者	岡宏昭\|
発行日	2012-03-23
出版物タイトル
資料タイプ	学位論文

植物培養細胞を活用して基礎研究と産学連携研究を追求して

著者	濱田博喜\|
発行日	2012-04
出版物タイトル	岡山実験動物研究会報
巻	28巻
資料タイプ	その他

日本産ナメクジウオの飼育コロニーの確立

著者	安井金也\|
発行日	2012-04
出版物タイトル	岡山実験動物研究会報
巻	28巻
資料タイプ	その他

Inactivation of Vibrio vulnificus hemolysin through mutation of the N- or C-terminus of the lectin-like domain

著者	Miyoshi, Shin-ichi\| Abe, Yuki\| Senoh, Mitsutoshi\| Mizuno, Tamaki\| Maehara, Yoko\| Nakao, Hiroshi\|
発行日	2011-05
出版物タイトル	Toxicon
巻	57巻
号	6号
資料タイプ	学術雑誌論文

Enterotoxigenic Escherichia coli CS6 gene products and their roles in CS6 structural protein assembly and cellular adherence

著者	Wajima, Takeaki\| Sabui, Subrata\| Fukumoto, Megumi\| Kano, Shigeyuki\| Ramamurthy, Thandavarayan\| Chatterjee, Nabendu Sekhar\| Hamabata, Takashi\|
発行日	2011-10
出版物タイトル	Microbial Pathogenesis
巻	51巻
号	4号
資料タイプ	学術雑誌論文

Different Responses to 5-fluoraouracil in Mutagenicity and Gene Expression between Two Human Lymphoblastoid Cell Lines with or without TP53 Mutation

JaLCDOI	10.18926/AMO/48262
フルテキストURL	66_2_119.pdf.pdf
著者	Oka, Hiroaki\| Ouchida, Mamoru\| Kondo, Takuya\| Morita, Fumio\| Shimizu, Kenji\|
抄録	Human lymphoblastoid TK6 and WTK-1 cells are widely used to detect mutagens in vitro. TK6 cells have wild-type TP53 alleles, while WTK-1 cells have one allele of mutated TP53. Both cells were treated with 5-fluorouracil (5-FU), and gene mutation assay and micronucleus assay were performed to clarify the differential response related to the TP53 gene status. The effects of 5-FU on gene expression were assessed by microarray and quantitative RT-PCR analyses. In WTK-1 cells, 5-FU increased the frequency of cells with micronucleus and mutation. In TK6 cells, frequency of cells with micronucleus was increased but the mutation frequency was not. The cytotoxicity induced by 5-FU was more prominent in TK6 cells than in WTK-1 cells. Analysis of gene expression showed that the genes involved in the TP53 pathway were up-regulated in TK6 cells but not in WTK-1 cells. The differential responses to 5-FU between these cell lines appeared to be due to the difference in the TP53 gene status, thus providing a molecular basis for the bioassays using these cell lines in the toxicology field. Our results indicate that the clinical efficacy of 5-FU chemotherapy may depend on the TP53 genotype.
キーワード	5-fluorouracil TP53 Tk mutation assays microarray analysis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2012-04
巻	66巻
号	2号
出版者	Okayama University Medical School
開始ページ	119
終了ページ	129
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	22525470
Web of Science KeyUT	000303175300005

Neurite Outgrowth of PC12 Mutant Cells Induced by Orange Oil and d-Limonene via the p38 MAPK Pathway

JaLCDOI	10.18926/AMO/48261
フルテキストURL	66_2_111.pdf.pdf
著者	Shinomiya, Misae\| Kawamura, Kenji\| Tanida, Emiko\| Nagoshi, Megumi\| Motoda, Hirotoshi\| Kasanami, Yoshiko\| Hiragami, Fukumi\| Kano, Yoshio\|
抄録	We studied the effects of natural essential oil on neurite outgrowth in PC12m3 neuronal cells to elucidate the mechanism underlying the action of the oils used in aromatherapy. Neurite outgrowth can be induced by nerve growth factor (NGF), where ERK and p38 MAPK among MAPK pathways play important roles in activating intracellular signal transduction. In this study, we investigated whether d-limonene, the major component of essential oils from oranges, can promote neurite outgrowth in PC12m3 cells, in which neurite outgrowth can be induced by various physical stimulations. We also examined by which pathways, the ERK, p38 MAPK or JNK pathway, d-limonene acts on PC12m3 cells. Our results showed that neurite outgrowth can be induced when the cells are treated with d-limonene. After treatment with d-limonene, we observed that p38 MAPK is strongly activated in PC12m3 cells, while ERK is weakly activated. In contrast, JNK shows little activity. A study using an inhibitor of p38 MAPK revealed that neurite outgrowth in PC12m3 cells is induced via the activation of p38 MAPK by d-limonene. The results thus indicate that d-limonene may promote neural cell differentiation mainly via activation of the p38 MAPK pathway.
キーワード	essential oil d-limonene p38 MAP kinase PC12 mutant cells
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2012-04
巻	66巻
号	2号
出版者	Okayama University Medical School
開始ページ	111
終了ページ	118
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	22525469
Web of Science KeyUT	000303175300004

Ataxia-Telangiectasia Mutated and the Mre11-Rad50-NBS1 Complex:Promising Targets for Radiosensitization

JaLCDOI	10.18926/AMO/48258
フルテキストURL	66_2_83.pdf.pdf
著者	Kuroda, Shinji\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
抄録	Radiotherapy plays a central part in cancer treatment, and use of radiosensitizing agents can greatly enhance this modality. Although studies have shown that several chemotherapeutic agents have the potential to increase the radiosensitivity of tumor cells, investigators have also studied a number of molecularly targeted agents as radiosensitizers in clinical trials based on reasonably promising preclinical data. Recent intense research into the DNA damage-signaling pathway revealed that ataxia-telangiectasia mutated (ATM) and the Mre11-Rad50-NBS1 (MRN) complex play central roles in DNA repair and cell cycle checkpoints and that these molecules are promising targets for radiosensitization. Researchers recently developed three ATM inhibitors (KU-55933, CGK733, and CP466722) and an MRN complex inhibitor (mirin) and showed that they have great potential as radiosensitizers of tumors in preclinical studies. Additionally, we showed that a telomerase-dependent oncolytic adenovirus that we developed (OBP-301 [telomelysin]) produces profound radiosensitizing effects by inhibiting the MRN complex via the adenoviral E1B55kDa protein. A recent Phase I trial in the United States determined that telomelysin was safe and well tolerated in humans, and this agent is about to be tested in combination with radiotherapy in a clinical trial based on intriguing preclinical data demonstrating that telomelysin and ionizing radiation can potentiate each other. In this review, we highlight the great potential of ATM and MRN complex inhibitors, including telomelysin, as radiosensitizing agents.
キーワード	ATM (ataxia-telangiectasia mutated) MRN (Mre11-Rad50-NBS1) complex radiosensitization adenovirus E1B55kDa
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2012-04
巻	66巻
号	2号
出版者	Okayama University Medical School
開始ページ	83
終了ページ	92
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	22525466
Web of Science KeyUT	000303175300001

骨形成不全症の治療

著者	田中弘之\|
発行日	2012-04-01
出版物タイトル	岡山医学会雑誌
巻	124巻
号	1号
資料タイプ	学術雑誌論文

S-1/CDDP術前化学療法により組織学的CRが得られた幽門狭窄合併進行胃癌の１例

著者	西崎正彦\| 藤原康宏\| 丁田泰宏\| 金澤卓\| 二宮基樹\| 藤原俊義\|
発行日	2012-04-01
出版物タイトル	岡山医学会雑誌
巻	124巻
号	1号
資料タイプ	学術雑誌論文

テロメア生物学から心筋再生医療の実用化へ

著者	王英正\|
発行日	2012-04-01
出版物タイトル	岡山医学会雑誌
巻	124巻
号	1号
資料タイプ	学術雑誌論文

ニガウリ抽出物の血糖降下作用に関する文献的考察

著者	万倉三正\| 野田泰子\| 森昭胤\|
発行日	2012-04-01
出版物タイトル	岡山医学会雑誌
巻	124巻
号	1号
資料タイプ	学術雑誌論文

同種抗原による移植片対白血病効果減弱のメカニズム

著者	朝倉昇司\| 橋本大吾\| 高嶋秀一郎\| 杉山暖子\| 前田嘉信\| 赤司浩一\| 谷本光音\| 豊嶋崇徳\|
発行日	2012-04-01
出版物タイトル	岡山医学会雑誌
巻	124巻
号	1号
資料タイプ	学術雑誌論文

ランビエ絞輪周囲のECMによるdiffusion barrier形成と跳躍伝導における役割

著者	別宮洋子\| 二宮善文\| 大橋俊孝\|
発行日	2012-04-01
出版物タイトル	岡山医学会雑誌
巻	124巻
号	1号
資料タイプ	学術雑誌論文

Promotion of IL-4- and IL-5-dependent differentiation of anti-μ-primed B cells by ascorbic acid 2-glucoside

著者	Ichiyama, Kenji\| Mitsuzumi, Hitoshi\| Zhong, Ming\| Tai, Akihiro\| Tsuchioka, Akihiro\| Kawai, Saeko\| Yamamoto, Itaru\| Gohda, Eiichi\|
発行日	2009-02-21
出版物タイトル	Immunology Letters
巻	122巻
号	2号
資料タイプ	学術雑誌論文