Survival days of patients with metastatic spinal tumors of lung cancer requiring surgery: a prospective multicenter study

Takahashi, Takuya; Hirai, Takashi; Shiratani, Yuki; Suzuki, Akinobu; Kakutani, Kenichiro; Kato, Satoshi; Tominaga, Hiroyuki; Inoue, Hirokazu; Sawada, Hirokatsu; Takegami, Norihiko; Nakanishi, Kazuo; Nakajima, Hideaki; Ishihara, Masayuki; Oshigiri, Tsutomu; Funayama, Toru; Iimura, Takuya; Tanishima, Shinji; Nakashima, Hiroaki; Yamabe, Daisuke; Hashimoto, Ko; Uotani, Koji; Funaba, Masahiro; Nagoshi, Narihito; Kobayakawa, Kazu; Yoshii, Toshitaka; Watanabe, Kazuyuki; Nakamae, Toshio; Kaito, Takashi; Inoue, Gen; Imagama, Shiro; Watanabe, Kota; Furuya, Takeo

doi:10.1038/s41598-025-08775-9

Permalink : https://ousar.lib.okayama-u.ac.jp/69068

ID	69068
フルテキストURL	fulltext.pdf 1.24 MB
著者	Takahashi, Takuya Department of Orthopedic Surgery, Institute of Science Tokyo Hirai, Takashi Department of Orthopedic Surgery, Institute of Science Tokyo Shiratani, Yuki Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University Suzuki, Akinobu Department of Orthopaedic Surgery, Osaka Metropolitan University Kakutani, Kenichiro Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine Kato, Satoshi Department of Orthopaedic Surgery Graduate School of Medical Sciences, Kanazawa University Tominaga, Hiroyuki Department of Orthopedic Surgery Graduate School of Medical and Dental Sciences, Kagoshima University Inoue, Hirokazu Rehabilitation Center, Jichi Medical University Hospital Sawada, Hirokatsu Department of Orthopaedic Surgery, Nihon University School of Medicine Takegami, Norihiko Department of Orthopaedic Surgery, Mie University Graduate School of Medicine Nakanishi, Kazuo Department of Orthopaedic Surgery, Kawasaki Medical School Nakajima, Hideaki Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui Ishihara, Masayuki Department of Orthopaedic surgery, Kansai Medical University Hospital Oshigiri, Tsutomu Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine Funayama, Toru Department of Orthopaedic Surgery Institute of Medicine, University of Tsukuba Iimura, Takuya Department of Orthopaedic Surgery, Dokkyo Medical University Tanishima, Shinji Division of Orthopedic Surgery, Department of Sensory and Motor Organs, School of Medicine, Faculty of Medicine, Tottori University Nakashima, Hiroaki Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine Yamabe, Daisuke Department of Orthopaedic Surgery, Iwate Medical University Hashimoto, Ko Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine Uotani, Koji Department of Orthopaedic Surgery, Okayama University Hospital ORCID Kaken ID Funaba, Masahiro Department of Orthopaedics Surgery, Yamaguchi University Graduate school of Medicine Nagoshi, Narihito Department of Orthopaedic Surgery, Keio University Kobayakawa, Kazu Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University Yoshii, Toshitaka Department of Orthopedic Surgery, Institute of Science Tokyo Watanabe, Kazuyuki Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine Nakamae, Toshio Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University Kaito, Takashi Department of Orthopedic Surgery, Osaka University Graduate School of Medicine Inoue, Gen Department of Orthopaedic Surgery, Kitasato University School of Medicine Imagama, Shiro Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine Watanabe, Kota Department of Orthopaedic Surgery, Keio University Furuya, Takeo Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University
抄録	Surgery for metastatic spinal tumors has improved postoperative activities of daily living. A few studies reported on prognostic factors assessed in large multicenter prospective studies for metastatic spinal tumors of lung cancer origin. This study aimed to determine preoperative prognostic factors in patients undergoing surgery for metastatic spinal tumors associated with lung cancer. This prospective registry study included 74 patients diagnosed and operated with metastatic spine tumors derived from lung cancer in 39 high-volume cancer centers. We examined the postoperative survival period and the preoperative factors related to postoperative survival time. We conducted univariate and multivariate Cox regression analyses to determine preoperative prognostic factors. The mean postoperative survival period was 343 days. Multivariate Cox regression analysis revealed a higher feeding score of vitality index, indications for molecularly targeted therapy, and a higher mobility score of Barthel index as independent factors associated with postoperative survival time in metastatic spinal tumors derived from lung cancer. Patients with indications for molecular-targeted therapy and good vitality exhibited longer survival. These results may help in surgical selection for patients with metastatic spinal tumors derived from lung cancer.
キーワード	Metastatic spinal tumor Lung cancer Postoperative survival period Barthel index Vitality index Molecularly targeted therapy
発行日	2025-07-06
出版物タイトル	Scientific Reports
巻	15巻
号	1号
出版者	Springer Science and Business Media LLC
開始ページ	24117
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2025
論文のバージョン	publisher
PubMed ID	40619496
DOI	10.1038/s41598-025-08775-9
Web of Science KeyUT	001523298400044
関連URL	isVersionOf https://doi.org/10.1038/s41598-025-08775-9
ライセンス	http://creativecommons.org/licenses/by-nc-nd/4.0/
Citation	Takahashi, T., Hirai, T., Shiratani, Y. et al. Survival days of patients with metastatic spinal tumors of lung cancer requiring surgery: a prospective multicenter study. Sci Rep 15, 24117 (2025). https://doi.org/10.1038/s41598-025-08775-9