ID | 21138 |
JaLCDOI | |
Sort Key | 9
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タイトル(別表記) | The Effect of Thermal Spring Water on Drug Absorption in Special Reference to Aspirin and Indomethacin
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フルテキストURL | |
著者 |
岡本 輝子
岡山大学医学部附属病院三朝分院
平尾 光宏
岡山大学医学部附属病院三朝分院
古野 勝志
岡山大学医学部附属病院三朝分院
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抄録 | It is thought that a drug reacts differently with media taken internally. The solubility of Aspirin is assured 600μg/ml in 30min. with Misasa spring water, whereas 400μg/ml with plain water. The parallel difference of 200μg/ml follows 10 min. thereafter. Maximum serum concentratin of 200μg/ml is obtained 2 hours after the internal use of Aspirin with Misasa spring water in parallel difference of 20μg/ml with plain water. In the case of Indomethacin intake, maximum serum concentration of 1.5μg/ml is obtained in 2 hours with plain water, whereas maximum serum concentration of 1μg/ml is obtained in the same period with Misasa spring water. However, the difference of 0.25μg/ml in serum concentration between the media internally taken is seen initially and after 4 hours under high concentration of Indomethacin. We, therefore, assume tentatively that the effect of Aspirin and Indomethacin is supposed to be enhanced with Misasa spring water taken internally.
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備考 | 原著論文 (Original Papers)
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出版物タイトル |
岡山大学温泉研究所報告
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発行日 | 1982-03-25
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巻 | 52巻
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出版者 | 岡山大学温泉研究所
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出版者(別表記) | Institute for Thermal Spring Research, Okayama University
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開始ページ | 45
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終了ページ | 50
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ISSN | 0369-7142
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NCID | AN00032853
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資料タイプ |
紀要論文
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OAI-PMH Set |
岡山大学
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言語 |
日本語
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論文のバージョン | publisher
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NAID | |
Eprints Journal Name | mmc
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