| ID | 14452 |
| Eprint ID | 14452
|
| フルテキストURL | |
| タイトル（別表記） | The role of endogenous thyrotropin releasing hormone (TRH) in maintenance of the blood pressure in awake and unrestrained rats with hemorrhagic hypotension
|
| 著者 |
宮崎 峰生
岡山大学医学部麻酔・蘇生学教室
|
| 抄録 | A pressor effect of TRH in hemorrhagic hypotensive rats was studied. First, TRH (1mg/kg, 2mg/kg, 5mg/kg), its analogue MK771 (0.2mg/kg) and anti-TRH antibody were given intravenously. The change in the mean arterial blood pressure (MAP) was observed. After administration of TRH, MAP rose dose-dependently, and it also rose after administration of MK771. The anti-TRH antibody significantly suppressed the compensatory and reflective increase of MAP following the hemorrhage. This suggested that the endogenous TRH plays an important role in the maintenance of MAP in the hemorrhagic hypotensive state. Next, the same hypotention models were made using adreno-demedullated rats. TRH or anti-TRH antibody was given intravenously. TRH significantly increased MAP, while the anti-TRH antibody suppressed MAP. This indicates that the pressor effect of TRH is not mediated by the adrenal medulla. The endogenous TRH may play its maintenance role of blood pressure via medulla oblongata.
|
| キーワード | 出血性低血圧
TRH
MK771
抗 TRH 抗体
副腎髄質除去ラット
|
| 備考 | 原著
|
| 発行日 | 1991
|
| 出版物タイトル |
岡山医学会雑誌
|
| 出版物タイトル（別表記） | Journal of Okayama Medical Association
|
| 巻 | 103巻
|
| 号 | 1-2号
|
| 出版者 | 岡山医学会
|
| 出版者（別表記） | Okayama Medical Association
|
| 開始ページ | 53
|
| 終了ページ | 63
|
| ISSN | 0030-1558
|
| NCID | AN00032489
|
| 資料タイプ |
学術雑誌論文
|
| オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/103/1-2/103_1-2_53/_article/-char/ja/
|
| 関連URL | http://www.okayama-u.ac.jp/user/oma/
|
| 言語 |
日本語
|
| 著作権者 | 岡山医学会
|
| 論文のバージョン | publisher
|
| 査読 |
有り
|
| Eprints Journal Name | joma
|
