To date, many techniques have been reported for vaginoplasty in male-to-female trans-sexual (MTFTS) patients, such as the use of a rectum transfer, a penile-scrotal flap and a reversed penile flap. However, none of these procedures is without its disadvantages. We developed a newly kind of flap for vaginoplasty, the M-shaped perineo-scrotal flap (M-shaped flap), using skin from both sides of the scrotum, shorn of hair by preoperative laser treatment. We applied this new type of flap in 7 MTFTS patients between January 2006 and January 2007. None of the flaps developed necrosis, and the patients could engage in sexual activity within 3 months of the operation. The M-shaped flap has numerous advantages: it can be elevated safely while retaining good vascularity, it provides for the construction of a sufficient deep vagina without a skin graft, the size of the flap is not influenced entirely by the length of the penis, and it utilizes skin from both sides of the scrotal area, which is usually excised.
en-copyright= kn-copyright= en-aut-name=NambaYuzaburo en-aut-sei=Namba en-aut-mei=Yuzaburo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SugiyamaNarushi en-aut-sei=Sugiyama en-aut-mei=Narushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamashitaShuji en-aut-sei=Yamashita en-aut-mei=Shuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HasegawaKenjiro en-aut-sei=Hasegawa en-aut-mei=Kenjiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IshiiKazushi en-aut-sei=Ishii en-aut-mei=Kazushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NasuYasutomo en-aut-sei=Nasu en-aut-mei=Yasutomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University en-keyword=vaginoplasty kn-keyword=vaginoplasty en-keyword=male-to-female transsexual kn-keyword=male-to-female transsexual en-keyword=perineo-scrotal flap kn-keyword=perineo-scrotal flap END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue=5 article-no= start-page=243 end-page=247 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=200910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Mastectomy in Female-to-male Transsexuals en-subtitle= kn-subtitle= en-abstract= kn-abstract=The first operative procedure in sex reassignment surgery (SRS) for female-to-male transsexuals (FTMTS) is mastectomy. This procedure includes the removal of mammary tissue, removal of excess skin, and reduction and proper repositioning of the nipple and areola complex. We have performed mastectomies in over 120 patients since January 2001 and want to describe the operative procedures we have developed. We classified our patients into 3 groups according to the patient's breast volume and the degree of ptosis, and we selected the operative procedure that was suitable for each group. At present all costs for SRS are assumed by the patient in Japan. If the FTMTS patient undergoes the entire series of SRS operations, he has to pay more than 3,000,000 yen. Thus the surgeon should select the proper operative procedure so that the patient can avoid unnecessary additional operations. We describe herein the techniques and the strategy for performing mastectomy in FTMTS.
en-copyright= kn-copyright= en-aut-name=NambaYuzaburo en-aut-sei=Namba en-aut-mei=Yuzaburo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WatanabeToshiyuki en-aut-sei=Watanabe en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=mastectomy kn-keyword=mastectomy en-keyword=female-to-male transsexual kn-keyword=female-to-male transsexual en-keyword=sex reassignment surgery kn-keyword=sex reassignment surgery END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=3 article-no= start-page=213 end-page=216 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200806 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Phantom erectile penis after sex reassignment surgery en-subtitle= kn-subtitle= en-abstract= kn-abstract=Between January 2001 and December 2007, we performed vaginoplasty as sex reassignment surgery in a total of 14 male-to-female transsexual (MTFTS) patients [1]. Several complications occurred such as partial flap necrosis, rectovaginal fistula formation and hypersensitivity of the neoclitoris. Just after the operation, some patients feel that their penises still exist, but by several weeks postoperatively, this sensation has disappeared. Herein we report a case of MTFTS in whom the sensation of a phantom erectile penis persisted for much longer.
en-copyright= kn-copyright= en-aut-name=NambaYuzaburo en-aut-sei=Namba en-aut-mei=Yuzaburo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SugiyamaNarushi en-aut-sei=Sugiyama en-aut-mei=Narushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamashitaShuji en-aut-sei=Yamashita en-aut-mei=Shuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TokuyamaEijiro en-aut-sei=Tokuyama en-aut-mei=Eijiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HasegawaKenjiro en-aut-sei=Hasegawa en-aut-mei=Kenjiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=gender identity disorder kn-keyword=gender identity disorder en-keyword=sex reassignment surgery kn-keyword=sex reassignment surgery en-keyword=phantom erectile penis kn-keyword=phantom erectile penis END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=6 article-no= start-page=415 end-page=419 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Vaginoplasty with a Pudendal-Thigh Flap in Intersexuals en-subtitle= kn-subtitle= en-abstract= kn-abstract=We treated 2 different types of intersexual patients who underwent a vaginoplasty with the pudendal-thigh flap. One was a female with testicular feminization syndrome for whom we reconstructed the total vagina with a pudendal-thigh flap, and the other was a female with an adrenogenital syndrome for whom we enlarged the introitus of the vagina with the same approach. There were no complications such as a flap necrosis. In addition, there was no stricture of the neo-vagina and no urinary problem.
en-copyright= kn-copyright= en-aut-name=NambaYuzaburo en-aut-sei=Namba en-aut-mei=Yuzaburo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SugiyamaNarushi en-aut-sei=Sugiyama en-aut-mei=Narushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamashitaShuji en-aut-sei=Yamashita en-aut-mei=Shuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HasegawaKenjiro en-aut-sei=Hasegawa en-aut-mei=Kenjiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakatsukaMikiya en-aut-sei=Nakatsuka en-aut-mei=Mikiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil= Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Gynecology and Obstetrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=vaginoplasty kn-keyword=vaginoplasty en-keyword=intersexual kn-keyword=intersexual en-keyword=pudendal-thigh flap kn-keyword=pudendal-thigh flap END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=4 article-no= start-page=233 end-page=236 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=200608 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Fibular osteoadiposal flap for treatment of tibial adamantinoma: a case report. en-subtitle= kn-subtitle= en-abstract= kn-abstract=We treated a case with left tibial adamantinoma by use of a contralateral fibular osteoadiposal flap. The donor site of conventional fibular osteocutaneous flap must be covered with a skin graft because if we close the donor skin defect directly, compartment syndrome might occur. We were able to close the donor skin defect because this combined type flap included only a small monitoring skin paddle. We present herein the utility of the osteoadiposal flap and show the value of a skin-sparing approach with a minimal aesthetic defect. en-copyright= kn-copyright= en-aut-name=NambaYuzaburo en-aut-sei=Namba en-aut-mei=Yuzaburo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KoshimaIsao en-aut-sei=Koshima en-aut-mei=Isao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SugiharaShinsuke en-aut-sei=Sugihara en-aut-mei=Shinsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SatoTohru en-aut-sei=Sato en-aut-mei=Tohru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=University of Tokyo, Tokyo affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University en-keyword=adamantinoma kn-keyword=adamantinoma en-keyword=fibular osteoadiposal flap kn-keyword=fibular osteoadiposal flap en-keyword=skin-sparing flap harvest kn-keyword=skin-sparing flap harvest END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue= article-no= start-page=11 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200710 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Material recycling of blast furnace slag by phase separation of glass kn-title=ガラスの分相現象を利用した高炉水砕スラグの再資源化技術の開発 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A novel recycling process of blast furnace slag was developed in order to obtain colorless silica－rich solids by using phase separation of borosilicate glass. B(2)O(3) was added to blast furnace slag to promote the phase separation. The slag glasses were heat-treated above glass transition temperatures. The slag glass prepared from blast furnace slag gelled after the heat treatment and the subsequent three types of acid treatment. The ratios of SiO(2) component in the gels were 40 - 60mass%. On the other hand, phase separation was observed on the surface of the slag glasses prepared from pre-treated slag by 2.5N HCI after the heat treatment. After soaking in acid, they did not gel and changed to insoluble colorless solids. According to compositional analyses, it was found that the insoluble colorless solids contained 70 - 90mass% SiO(2). No colored ions such as Cr, Mn, and Fe were confirmed in the remaining insolubles by optical absorption measurement. Therefore, the colorless silica-rich solids were successfully obtained in the present process. The end products obtained in the present process are expected as material of glass. en-copyright= kn-copyright= en-aut-name=SakidaShinichi en-aut-sei=Sakida en-aut-mei=Shinichi kn-aut-name=崎田真一 kn-aut-sei=崎田 kn-aut-mei=真一 aut-affil-num=1 ORCID= en-aut-name=MikamiSyuuhei en-aut-sei=Mikami en-aut-mei=Syuuhei kn-aut-name=三上修平 kn-aut-sei=三上 kn-aut-mei=修平 aut-affil-num=2 ORCID= en-aut-name=NanbaTokuro en-aut-sei=Nanba en-aut-mei=Tokuro kn-aut-name=難波徳郎 kn-aut-sei=難波 kn-aut-mei=徳郎 aut-affil-num=3 ORCID= en-aut-name=MiuraToshinari en-aut-sei=Miura en-aut-mei=Toshinari kn-aut-name=三浦嘉也 kn-aut-sei=三浦 kn-aut-mei=嘉也 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学保健環境センター環境安全部門 affil-num=2 en-affil= kn-affil=岡山大学環境理工学部環境物質工学科 affil-num=3 en-affil= kn-affil=岡山大学環境理工学部環境物質工学科 affil-num=4 en-affil= kn-affil=岡山大学環境理工学部環境物質工学科 en-keyword=Blast furnace slag kn-keyword=Blast furnace slag en-keyword=Recycling kn-keyword=Recycling en-keyword=Colorless silica-rich solids kn-keyword=Colorless silica-rich solids en-keyword=Phase separation kn-keyword=Phase separation en-keyword=Glass kn-keyword=Glass END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=1 article-no= start-page=33 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Contribution of cell cultures to the Nobel Prize kn-title=細胞培養のノーベル賞への貢献 en-subtitle= kn-subtitle= en-abstract= kn-abstract=約1世紀前に, 生きた組織や細胞を動物の体外に取り出した研究―組織培養あるいは細胞培養―が始まった．その後の研究の流れの中で, 1) 組織・細胞培養の特性を生かして行われた研究でノーベル賞に輝いた研究, 2) 組織・細胞培養の経験をもつノーベル賞受賞者, 3) ノーベル賞にはならなかったけれども特記できると私が考える細胞培養の研究，などについて取り上げてみたい. en-copyright= kn-copyright= en-aut-name=NambaMasayoshi en-aut-sei=Namba en-aut-mei=Masayoshi kn-aut-name=難波正義 kn-aut-sei=難波 kn-aut-mei=正義 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=新見公立大学 en-keyword=細胞 kn-keyword=細胞 en-keyword=培養 kn-keyword=培養 en-keyword=ノーベル賞 kn-keyword=ノーベル賞 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=9 article-no= start-page=1557 end-page=1559 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19560930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influence of Parathion-poisoing on the Function of Reticulo-endotherial System kn-title=パラチオン中毒の網内系機能に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The function of reticulo-endotherial system was examined by means of the carbon black phagocytosis (Sugiyama) and the congo-red test (Adler and Reimann). 1. The decrease of phagocytosis and the increase of congo-red index take place 2-3 days after subcutaneous injection of parathion (8 mg/kg for rabbits, 1-3 mg/kg for dogs). 2. Daily injecting the small dose of parathion (1 mg/kg for rabbits, 1-2 mg/kg for dogs), the disturbance above mentioned is also proved, and it goes on longer. 3. At the onset of parathion-poisoning in man, the congo-red index shows very high and returns to normal after 10-20 days. It is concluded that the function of reticulo-endotherial system is out of order by the parathion-poisoning, and it remains after 10-20 days. en-copyright= kn-copyright= en-aut-name=NambaTatsuji en-aut-sei=Namba en-aut-mei=Tatsuji kn-aut-name=難波達治 kn-aut-sei=難波 kn-aut-mei=達治 aut-affil-num=1 ORCID= en-aut-name=KimuraKiichiro en-aut-sei=Kimura en-aut-mei=Kiichiro kn-aut-name=木村基一郎 kn-aut-sei=木村 kn-aut-mei=基一郎 aut-affil-num=2 ORCID= en-aut-name=NakayamaAkitoshi en-aut-sei=Nakayama en-aut-mei=Akitoshi kn-aut-name=中山章壮 kn-aut-sei=中山 kn-aut-mei=章壮 aut-affil-num=3 ORCID= en-aut-name=TanimotoHajime en-aut-sei=Tanimoto en-aut-mei=Hajime kn-aut-name=谷本一 kn-aut-sei=谷本 kn-aut-mei=一 aut-affil-num=4 ORCID= en-aut-name=MaedaAkira en-aut-sei=Maeda en-aut-mei=Akira kn-aut-name=前田昭 kn-aut-sei=前田 kn-aut-mei=昭 aut-affil-num=5 ORCID= en-aut-name=TambaraShigeo en-aut-sei=Tambara en-aut-mei=Shigeo kn-aut-name=丹原茂雄 kn-aut-sei=丹原 kn-aut-mei=茂雄 aut-affil-num=6 ORCID= en-aut-name=KimuraTakashi en-aut-sei=Kimura en-aut-mei=Takashi kn-aut-name=木村峻士 kn-aut-sei=木村 kn-aut-mei=峻士 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=9 article-no= start-page=1551 end-page=1556 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19560930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influence of Parathion-poisoning on Respiratory and Circulatory Function and the Effects of some Therapeutics kn-title=パラチオン中毒に於ける呼吸及び循環機能並びに之に及ぼす治療剤の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Respiratory movement and blood pressure were recorded on the dog with parathion-poisoning. 1. After a few minutes of increasing of rate and amplitude, the respiratory movement go down weaker and irregular. Thus the movement ceases by a single intravenous injection of 10 mg/kg parathion. Blood pressure shows transitory rise, then it falls gradually and is attended by a marked slowing of the heart beats after respiratory failure. 2. The changes caused by parathion injection are protected by 5 mg/kg atropine i. v. 3. The atropine- like effects are displayed, too, by 1 mg/kg Tropin, 4 mg/kg Finalin and 3 mg/kg Pro-banthin i. v. 4. Intravenous injection of 100 mg/kg Theraptique, 20 mg/kg Guronsan and 300 mg/kg Sod. thiosulf. are of no use, besides the former display a brief period of strong respiratory stimulation. en-copyright= kn-copyright= en-aut-name=NambaTatsuji en-aut-sei=Namba en-aut-mei=Tatsuji kn-aut-name=難波達治 kn-aut-sei=難波 kn-aut-mei=達治 aut-affil-num=1 ORCID= en-aut-name=HachiyaRyoma en-aut-sei=Hachiya en-aut-mei=Ryoma kn-aut-name=蜂谷良馬 kn-aut-sei=蜂谷 kn-aut-mei=良馬 aut-affil-num=2 ORCID= en-aut-name=KimuraKiichiro en-aut-sei=Kimura en-aut-mei=Kiichiro kn-aut-name=木村基一郎 kn-aut-sei=木村 kn-aut-mei=基一郎 aut-affil-num=3 ORCID= en-aut-name=TanimotoHajime en-aut-sei=Tanimoto en-aut-mei=Hajime kn-aut-name=谷本一 kn-aut-sei=谷本 kn-aut-mei=一 aut-affil-num=4 ORCID= en-aut-name=NakayamaAkitoshi en-aut-sei=Nakayama en-aut-mei=Akitoshi kn-aut-name=中山章壮 kn-aut-sei=中山 kn-aut-mei=章壮 aut-affil-num=5 ORCID= en-aut-name=NakazawaTakeshi en-aut-sei=Nakazawa en-aut-mei=Takeshi kn-aut-name=中沢峻士 kn-aut-sei=中沢 kn-aut-mei=峻士 aut-affil-num=6 ORCID= en-aut-name=TambaraShigeo en-aut-sei=Tambara en-aut-mei=Shigeo kn-aut-name=丹原茂雄 kn-aut-sei=丹原 kn-aut-mei=茂雄 aut-affil-num=7 ORCID= en-aut-name=MaedaAkira en-aut-sei=Maeda en-aut-mei=Akira kn-aut-name=前田昭 kn-aut-sei=前田 kn-aut-mei=昭 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=9 article-no= start-page=1547 end-page=1549 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19560930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Tissue Cholinesterase Inhibitory Action of Parathion kn-title=Parathionの臓器cholinesterase阻害作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Rabbits were given parathion subcutaneously and the cholinesterase of tissues ere estimated manometrically. 1. Rabbits was given 100 mg/kg of parathion, and at the time of death in 45 minutes the cholinesterase activity of plasma fell to 15% of normal, erythrocyte 19%, spinal cord 22%, brain 25%, heart 45%, intestine 48%, kidney 49%, liver and muscle 51%, spleen 57%, lung 61% and stomach 87%. 2. Tissue cholinesterase activity of plasma of rabbits subcutaneouslly injected 5 mg/kg of parathion fell to 15% in 12 hours, lung 18%, 12 hs., erythrocyte 23%, 12 hs., kidney 23%, 48 hs., spleen 25%, 6 hs., stomach 33%, 6 hs., spinal cord 33%, 12hs., brain 41%, 6 hs., heart 45%, 6 hs., intestine 49%, 12 hs., liver 57%, 12 hs., and muscle 58%, 6 hs., 3. Discussion were made on these data. en-copyright= kn-copyright= en-aut-name=NambaTatsuji en-aut-sei=Namba en-aut-mei=Tatsuji kn-aut-name=難波達治 kn-aut-sei=難波 kn-aut-mei=達治 aut-affil-num=1 ORCID= en-aut-name=YamadaMinoru en-aut-sei=Yamada en-aut-mei=Minoru kn-aut-name=山田稔 kn-aut-sei=山田 kn-aut-mei=稔 aut-affil-num=2 ORCID= en-aut-name=FukuharaArimitsu en-aut-sei=Fukuhara en-aut-mei=Arimitsu kn-aut-name=福原有光 kn-aut-sei=福原 kn-aut-mei=有光 aut-affil-num=3 ORCID= en-aut-name=KimuraTakashi en-aut-sei=Kimura en-aut-mei=Takashi kn-aut-name=木村峻士 kn-aut-sei=木村 kn-aut-mei=峻士 aut-affil-num=4 ORCID= en-aut-name=MaedaAkira en-aut-sei=Maeda en-aut-mei=Akira kn-aut-name=前田昭 kn-aut-sei=前田 kn-aut-mei=昭 aut-affil-num=5 ORCID= en-aut-name=TambaraShigeo en-aut-sei=Tambara en-aut-mei=Shigeo kn-aut-name=丹原茂雄 kn-aut-sei=丹原 kn-aut-mei=茂雄 aut-affil-num=6 ORCID= en-aut-name=YamamotoAkiyoshi en-aut-sei=Yamamoto en-aut-mei=Akiyoshi kn-aut-name=山本昭美 kn-aut-sei=山本 kn-aut-mei=昭美 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山木学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山木学医学部平木内科教室 affil-num=3 en-affil= kn-affil=岡山木学医学部平木内科教室 affil-num=4 en-affil= kn-affil=岡山木学医学部平木内科教室 affil-num=5 en-affil= kn-affil=岡山木学医学部平木内科教室 affil-num=6 en-affil= kn-affil=岡山木学医学部平木内科教室 affil-num=7 en-affil= kn-affil=岡山木学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=8 article-no= start-page=1211 end-page=1217 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19560831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Toxicity of New Organophosphorous Insecticides kn-title=新有機燐農薬の毒性 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The toxicity of Diazinon, Chlorthion and Sumicide are studied in comparison with parathion The approximate LD(50) for rabbit are (mg per kg of weight) By the application of these compound, the changes are as follows; 1) Blood cholinesterase of rabbit, both serum and blood corpuscle, are similarly inhibited as the case of Parathion. 2) Symptom of poisoning with rabbit is the same as Parathion. 3) By the rabbit, there occur leucocytosis, mainly due to pseudoeosinophils, and the Arneth count is deflected to the left. Lymphocyte shows relative decrease. 4) Frog heart is examined by Staub-Fuhner method. Heart block that can be made by over 10(-8) concentration of Parathion, also occurs by 10(-7) Diazinon and 10(-6) Chlorthion. 5) The blood vessels of rabbit ear are dilated by the application of 0.1mg Diazinon. 6) Diazinon and Chlorthion make the lowering of arterial blood pressure in the experiment with dog. 7) By the subcutaneous application of these compound the rabbit serum protein and albumin increase, and gamma-globulin decreases. en-copyright= kn-copyright= en-aut-name=NambaTatsuji en-aut-sei=Namba en-aut-mei=Tatsuji kn-aut-name=難波達治 kn-aut-sei=難波 kn-aut-mei=達治 aut-affil-num=1 ORCID= en-aut-name=HachiyaRyoma en-aut-sei=Hachiya en-aut-mei=Ryoma kn-aut-name=蜂谷良馬 kn-aut-sei=蜂谷 kn-aut-mei=良馬 aut-affil-num=2 ORCID= en-aut-name=KurodaYuichi en-aut-sei=Kuroda en-aut-mei=Yuichi kn-aut-name=黑田祐一 kn-aut-sei=黑田 kn-aut-mei=祐一 aut-affil-num=3 ORCID= en-aut-name=YamadaMinoru en-aut-sei=Yamada en-aut-mei=Minoru kn-aut-name=山田稔 kn-aut-sei=山田 kn-aut-mei=稔 aut-affil-num=4 ORCID= en-aut-name=KimuraKiichiro en-aut-sei=Kimura en-aut-mei=Kiichiro kn-aut-name=木村基一郎 kn-aut-sei=木村 kn-aut-mei=基一郎 aut-affil-num=5 ORCID= en-aut-name=FukuharaArimitsu en-aut-sei=Fukuhara en-aut-mei=Arimitsu kn-aut-name=福原有光 kn-aut-sei=福原 kn-aut-mei=有光 aut-affil-num=6 ORCID= en-aut-name=MaedaAkira en-aut-sei=Maeda en-aut-mei=Akira kn-aut-name=前田昭 kn-aut-sei=前田 kn-aut-mei=昭 aut-affil-num=7 ORCID= en-aut-name=NakazawaTakeshi en-aut-sei=Nakazawa en-aut-mei=Takeshi kn-aut-name=中沢彪 kn-aut-sei=中沢 kn-aut-mei=彪 aut-affil-num=8 ORCID= en-aut-name=YoshikawaKiyoshi en-aut-sei=Yoshikawa en-aut-mei=Kiyoshi kn-aut-name=吉川潔 kn-aut-sei=吉川 kn-aut-mei=潔 aut-affil-num=9 ORCID= en-aut-name=KimuraTakashi en-aut-sei=Kimura en-aut-mei=Takashi kn-aut-name=木村峻士 kn-aut-sei=木村 kn-aut-mei=峻士 aut-affil-num=10 ORCID= en-aut-name=TambaraShigeo en-aut-sei=Tambara en-aut-mei=Shigeo kn-aut-name=丹原茂雄 kn-aut-sei=丹原 kn-aut-mei=茂雄 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=9 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=10 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=11 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=8 article-no= start-page=1207 end-page=1209 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19560831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Fate of Parathion in vivo kn-title=生体におけるパラチオンの運命 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Parathion is distributed equally in the poisoned human bodies, as it has been in the case of experimental animals, and disappeared after 24-48 hours. This may be attributed to the splitting of parathion both p-nitrophenol and diethyl (thio) phosphate. The most part of p-nitrophenol is excreted in the urin within 1-2 days and only a part of it prolonged into a week accompaniing no sign of poisoning. It is said that diethyl (thio) phosphate is excreted similary, but poisonus (1/4-1/5 of parathion) for the human bodies and animals. The splitting above mentioned is based on the enzym action, including cholinesterase which is found in the animal sera and organ extracts. The parathion splitting action of serum is inhibited in the case of various kinds of disease. en-copyright= kn-copyright= en-aut-name=NambaTatsuji en-aut-sei=Namba en-aut-mei=Tatsuji kn-aut-name=難波達治 kn-aut-sei=難波 kn-aut-mei=達治 aut-affil-num=1 ORCID= en-aut-name=TanimotoHajime en-aut-sei=Tanimoto en-aut-mei=Hajime kn-aut-name=谷本一 kn-aut-sei=谷本 kn-aut-mei=一 aut-affil-num=2 ORCID= en-aut-name=KimuraKiichiro en-aut-sei=Kimura en-aut-mei=Kiichiro kn-aut-name=木村基一郎 kn-aut-sei=木村 kn-aut-mei=基一郎 aut-affil-num=3 ORCID= en-aut-name=FukuharaArimitsu en-aut-sei=Fukuhara en-aut-mei=Arimitsu kn-aut-name=福原有光 kn-aut-sei=福原 kn-aut-mei=有光 aut-affil-num=4 ORCID= en-aut-name=YamadaMinoru en-aut-sei=Yamada en-aut-mei=Minoru kn-aut-name=山田稔 kn-aut-sei=山田 kn-aut-mei=稔 aut-affil-num=5 ORCID= en-aut-name=NakazawaTakeshi en-aut-sei=Nakazawa en-aut-mei=Takeshi kn-aut-name=中沢彪 kn-aut-sei=中沢 kn-aut-mei=彪 aut-affil-num=6 ORCID= en-aut-name=ShiromotoTetsuzo en-aut-sei=Shiromoto en-aut-mei=Tetsuzo kn-aut-name=城本鉄蔵 kn-aut-sei=城本 kn-aut-mei=鉄蔵 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=4 cd-vols= no-issue=1 article-no= start-page=147 end-page=158 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990226 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Photoconductive and Photovoltaic Properties in Cadmium Bismuth Aluminate Glasses en-subtitle= kn-subtitle= en-abstract= kn-abstract=Photo-induced phenomena such as photoconductive and photovoltaic effects were investigated for the glasses in CdO-Bi(2)O(3)-Al(2)O(3) system. Photoconductive effect was characterized by a slow decay of photocurrent (persitent photoconductivity). The decay rate decreased with increasing CdO content and decreasing Bi(2)O(3) content. Photovoltage was very small at room temperature but increased to an obvious value on heating. The photoconductivity and photovoltage were increased with CdO content and enhanced by heat treatment in air. The valence band spectra of X-ray photoelectron spectroscopy showed that the hybridization of Cd 4d and O 2p orbitals increases with decreasing Bi(2)O(3) content and increasing CdO content in the glasses. As the results maximum tends to flat. This type of band structure inhibits the rapid recombination of electrons and holes. The persistent photoconductivity of the glasses may be attributed to deep energy level of DX centers. Deep energy levels of the glasses are able to prevent the recombination because they have a repulsive barrier for both electron emission and capture. en-copyright= kn-copyright= en-aut-name=ChenDanping en-aut-sei=Chen en-aut-mei=Danping kn-aut-name=陳丹平 kn-aut-sei=陳 kn-aut-mei=丹平 aut-affil-num=1 ORCID= en-aut-name=WatanabeTomohiro en-aut-sei=Watanabe en-aut-mei=Tomohiro kn-aut-name=渡辺智大 kn-aut-sei=渡辺 kn-aut-mei=智大 aut-affil-num=2 ORCID= en-aut-name=MiuraYoshinari en-aut-sei=Miura en-aut-mei=Yoshinari kn-aut-name=三浦嘉也 kn-aut-sei=三浦 kn-aut-mei=嘉也 aut-affil-num=3 ORCID= en-aut-name=NanbaTokuro en-aut-sei=Nanba en-aut-mei=Tokuro kn-aut-name=難波徳郎 kn-aut-sei=難波 kn-aut-mei=徳郎 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Wuhan University of Technology affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 en-keyword=Photoconductivity kn-keyword=Photoconductivity en-keyword=Photovoltage kn-keyword=Photovoltage en-keyword=Persistent photoconductivity kn-keyword=Persistent photoconductivity en-keyword=CdO-Bi(2)O(3)-Al(2)O(3) glasses kn-keyword=CdO-Bi(2)O(3)-Al(2)O(3) glasses en-keyword=Electronic state kn-keyword=Electronic state END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=5 article-no= start-page=357 end-page=360 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19560531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=トキソプラスマ症の研究 第1報 岡山近郊に於けるトキソプラスミン皮内反応陽性率 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=難波益之 kn-aut-sei=難波 kn-aut-mei=益之 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大月三郎 kn-aut-sei=大月 kn-aut-mei=三郎 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小川哲郎 kn-aut-sei=小川 kn-aut-mei=哲郎 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小野昌也 kn-aut-sei=小野 kn-aut-mei=昌也 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=那須弘之 kn-aut-sei=那須 kn-aut-mei=弘之 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=更井啓介 kn-aut-sei=更井 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=河田三郎 kn-aut-sei=河田 kn-aut-mei=三郎 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=上永広済 kn-aut-sei=上永 kn-aut-mei=広済 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=湯之上茂 kn-aut-sei=湯之上 kn-aut-mei=茂 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=5-1 article-no= start-page=2183 end-page=2188 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590415 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Effects of "Moriamin S" (Solution of Amino Acids for the Injection) on the Induction and Growth of DAB Hepatoma kn-title=必須純アミノ酸結晶注射液「強力モリアミンS」のDAB肝癌発癌過程に与える影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this paper, the results of the several observations on the effects of high amino acids dosage on the induction and the growth of the hepatoma in DAB feeding rats have been reported. High dosage of amino acids (Moriamin S) proved to give no effect on the induction or growing rate of tumors, the blood pictures. the protein fractions of serum and ascites, and the non hemin iron level, the catalase and the succinic dehydrogenase activities and the histological pictures showed to be in the range of those of control animals fed DAB without other treatments. Results show that the long dulated injection of aminol acids for the purpose of retaining. the nutrient to the patients bearing the cancer will not act to accelrate the growth of tumors. en-copyright= kn-copyright= en-aut-name=KobayashiJunichi en-aut-sei=Kobayashi en-aut-mei=Junichi kn-aut-name=小林淳一 kn-aut-sei=小林 kn-aut-mei=淳一 aut-affil-num=1 ORCID= en-aut-name=UtsumiKozo en-aut-sei=Utsumi en-aut-mei=Kozo kn-aut-name=内海耕慥 kn-aut-sei=内海 kn-aut-mei=耕慥 aut-affil-num=2 ORCID= en-aut-name=AwaiMitiyas en-aut-sei=Awai en-aut-mei=Mitiyas kn-aut-name=粟井通泰 kn-aut-sei=粟井 kn-aut-mei=通泰 aut-affil-num=3 ORCID= en-aut-name=NambaYukikazu en-aut-sei=Namba en-aut-mei=Yukikazu kn-aut-name=難波幸一 kn-aut-sei=難波 kn-aut-mei=幸一 aut-affil-num=4 ORCID= en-aut-name=HayashiHiromu en-aut-sei=Hayashi en-aut-mei=Hiromu kn-aut-name=林弘 kn-aut-sei=林 kn-aut-mei=弘 aut-affil-num=5 ORCID= en-aut-name=TogawaSatoru en-aut-sei=Togawa en-aut-mei=Satoru kn-aut-name=戸川智 kn-aut-sei=戸川 kn-aut-mei=智 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部病理学教室 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=1-4 article-no= start-page=51 end-page=58 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=1956 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An autopsy case of Primaly leiomyosarcoma of the spermatic cord. kn-title=睾丸部(精系下部)に原発した滑平筋肉腫の1剖検例 en-subtitle= kn-subtitle= en-abstract=A case of malignant myogenous tumor originated on the left spermatic cord of 49 aged man is presented. This tumor was found as a painless tumor in the testicular region about 7 years before the death of patient, and one year later it grew to a child-head sized tumor showing a rapid development. Clinically the tumor was diagnosed as a cancer of the testis and resected surgically. (Fig. 1) No metastasized tumor was recognized at that time. However, 3 years and a half later a new tumor appeared on the center of the heald wound. The relapsed tumor was resected again, but after about one year and a half a tumor reappeared on the same region (Fig. 4) accompaning with an extensive metastasis in the thoracic cavity. (Fig. 8) The patient died by heart failure caused by the metastasized tumors. Anatomical and histopathological observations revealed that this tumor was a leiomyosarcoma originated in the lower region of the left spermatic cord. The tumor tissues consisted of whorled masses of polymorphic spindel-shaped cells with lod-shaped mucleus similar to the immature smooth muscle cells. (Fig. 9 & 7) kn-abstract= en-copyright= kn-copyright= en-aut-name=SoKenji en-aut-sei=So en-aut-mei=Kenji kn-aut-name=宗謙治 kn-aut-sei=宗 kn-aut-mei=謙治 aut-affil-num=1 ORCID= en-aut-name=YabeTadataka en-aut-sei=Yabe en-aut-mei=Tadataka kn-aut-name=矢部忠孝 kn-aut-sei=矢部 kn-aut-mei=忠孝 aut-affil-num=2 ORCID= en-aut-name=NambaYikikazu en-aut-sei=Namba en-aut-mei=Yikikazu kn-aut-name=難波幸一 kn-aut-sei=難波 kn-aut-mei=幸一 aut-affil-num=3 ORCID= en-aut-name=NoharaNosomi en-aut-sei=Nohara en-aut-mei=Nosomi kn-aut-name=野原望 kn-aut-sei=野原 kn-aut-mei=望 aut-affil-num=4 ORCID= en-aut-name=OuraIsao en-aut-sei=Oura en-aut-mei=Isao kn-aut-name=大浦功夫 kn-aut-sei=大浦 kn-aut-mei=功夫 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=3-2 article-no= start-page=1311 end-page=1317 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Effect of Oxygen Inhalation Part 3. The Effect of Oxygen Inhalation on the Production of the Connective Tissues kn-title=酸素吸入に関する実験的研究 第3編 結合織の増生に及ぼす酸素吸入の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=After inplanting a small sponge block subcutaneously the production of the fibroblasts and capillaries growing into the sponge block have been observed in the rats given oxygen inhalationfor 12 hours a day, and on comparing it to that of the sponge bearing animals living on air, some delay in the growth of the granulation tissues has been found in the O(2)-inspiring animals. en-copyright= kn-copyright= en-aut-name=NambaYukikazu en-aut-sei=Namba en-aut-mei=Yukikazu kn-aut-name=難波幸一 kn-aut-sei=難波 kn-aut-mei=幸一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部病理学教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=3-2 article-no= start-page=1301 end-page=1310 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Effect of Oxygen Inhalation Part 2. Histogic Changes caused by the Repeated Oxygen Inhalation kn-title=酸素吸入に関する実験的研究 第2編 酸素吸入に依る病理組織学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By observing the organs from the animals killed after the various durations of oxygen inhalation, the author reveals the following histologic changes: The inhalation of O(2), 12 houts daily, results in the heavy depostion of hemosiderin in the liver and spleen with the capillary stagnation. The severe damages in the wall of artery and arterioles are the general changes. These damages found in the vascular system will be responsible for the other histologic changes, perivascular edema and cell infiltration, thickening of the alveolar wall with the cell proliferation, localized degenerative changes of heart muscle, alternative degeneration and regeneration in the liver parenchym and the slight atrophy of glomerulus in the kidney. Active erythropoietic picture can be seen in bone marrow but decreaded number in normoblasts. The view of the author is that these changes will be the toxic action of O(2) desolved in blood plasm, which may have an active oxidizing effect. The reduction oferythrocyte number seems to be caused by the inhibition of maturation oferythroblasts, and the increased demolition of red cells in the circulating blood. en-copyright= kn-copyright= en-aut-name=NambaYukikazu en-aut-sei=Namba en-aut-mei=Yukikazu kn-aut-name=難波幸一 kn-aut-sei=難波 kn-aut-mei=幸一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部病理学教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=3-2 article-no= start-page=1293 end-page=1300 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Effect of Oxygen Inhalation Part 1. Observation on the Blood in the Oxygen Inhalation kn-title=酸素吸入に関する実験的研究 第1編 高濃度酸素吸入に依る血液有形成分の変化に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=The changes in the general condtions and blood have been observed in the rats receiving oxygen iehalation for 12 hours a day. In the first stage when the animals are laced in an oxygen chamber, they become less active and sooner or later they fall into a sleeping state with a reduced respiation frequency without taking food. After about 20 days' training even in the oxygen atmosphere they show a little movement with some activity and a little increase in appetite. After about 30 days in the oxygen chamber they begin to act almost as if they were outside the chamber with a slight loss in body weight. Hemoglobin content of blood decreases day by day during the first 20 days, reaching a new equilibrium, 20-30 per cent of the original value, which is kept up for the following 40 days without any change. Red cell number continues to fall reaching the minimum value after about 20 to 30 days, 90 per cent of the original number, and increase gradually reaching the original level about 2 months after the initiation. The reticulocyte number increases day by day reaching the maximum of 52.3 per cent after 10 days and keeps this level till the end of the experiment, i. e for two months. Leukocyte number is kept in a normal range throughout the experimental days. From the above experimental data the author concludes that the decrease in hemoglobin content seems to be due to the toxic action of oxygen itself but far from the adaptation syndrome, as only 2 per cent or less decrease in hemoglobin can be expected from the theoretical calculation in the oxygenation rat of hemoglobin. en-copyright= kn-copyright= en-aut-name=NambaYukikazu en-aut-sei=Namba en-aut-mei=Yukikazu kn-aut-name=難波幸一 kn-aut-sei=難波 kn-aut-mei=幸一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部病理学教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=2-2 article-no= start-page=825 end-page=831 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Enzymatic Properties of Shigella Dysenteriae Part 2. Catalase and Peroxidase Activities kn-title=Sh. dysenteriaeの酵素的性状について 第2篇 catalase, peroxidase作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By studying the influences of H(2)O(2) on the catalase and peroxidase actions and metabolisms of cells belonging to Sh. dysenteri 1-7, the author obtained the following results: 1. No evidence of H(2)O(2) accumulation either by cells with catalase or those without catalase can at all be seen during the growth or glucose oxidation. 2. In the relationshp betwen the peroxidase activity and H(2)O(2) concentration, the cells possessing catalase differs from without catalase. 3. The addition of glucose even in the case of cells lacking catase will enable to dispose of H(2)O(2). 4. In the case of the cells possesing no catalase, it seems that H(2)O(2) is not a all produced in the course of the metabolism, or some H(2)O(2) is produced momentarily but such H(2)O(2) is immediately disposed of by pyruvate or other substances produced during the metabolism. en-copyright= kn-copyright= en-aut-name=NanbaToshio en-aut-sei=Nanba en-aut-mei=Toshio kn-aut-name=難波敏夫 kn-aut-sei=難波 kn-aut-mei=敏夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=2-2 article-no= start-page=815 end-page=824 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Enzymatic Properties of Shigella dysenteri ea Part 1. The Nutrition Requirement for Growth and the Substrate Oxidation of Resting Cells kn-title=Sh. dysenteriaeの酵素的性状について 第1篇 発育に於ける栄養要求, 及び静止菌の基質酸化 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using the standard strains belonging to Sh. dysenteri 1. (A1)-7 (A7) as the test bacteria, the author studied the nutrition requirement of the growtn and enzymatic properties of these cells; and obtained the following results: 1. In comparing the catalase activity of each cell A(6) and A(7) show a marked activity, and A(2) slightly, while A(1), A(3), A(4), and A(5) show no activity at all. 2. When the nutrition requirements for the growth are compared, A(7) is found to be able to grow in the most simple medium of all, followed by A(6) and A(2). A(1), A(3), A(4) and A(5) possessing no catalase show a tendency to require a more stringent nutrition than those possessing catalase. 3. Looking over the effects of several inhibitory agents against the glucose oxidation of these cells, no clear-cut difference can be observed between the cells with catalaes and without catalase. en-copyright= kn-copyright= en-aut-name=NanbaToshio en-aut-sei=Nanba en-aut-mei=Toshio kn-aut-name=難波敏夫 kn-aut-sei=難波 kn-aut-mei=敏夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=7 article-no= start-page=2341 end-page=2354 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimenlal Studies on the Influences of Hypotension and Hypothermia upon the Electroencephalogram and Brain Edema Part Ⅱ. On the Influences of Hypothermia upon Electroencephalogram and Brain Edema kn-title=低血圧, 低体温麻酔の脳波及び脳浮腫に及ぼす影響に関する実験的研究 第2編 低体温麻酔の脳波及び脳浮腫に及ぼす影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=It is known that the hypothermic anesthesia with autonomic nerve blocking agents causes not only less bleeding, but also prevents shock or brain edema which is often seen in craniotomy. The author studied these effects of potentiated narkosis or hypothermia from the view point of electroencephalogram and brain water content. With intraperitoneal injection of 10% Dial solution for premedication in all cases and with chlorpromazine as the blocking agent, dogs were anesthetized by intratracheal intubation with ether, and were cooled by ice bags until the rectal temperature became about 34°~32℃. And the following results were obtained. In the group of potentiated narkosis with Dial and chlorpromazine, the decrease of delta index was seen and the brain water contents showed no change compared with the contrast group. In the group of hypothermia with chlorpromazine, the decrease of delta index was seen and the brain water content showed no change. In the group of hypothermic anesthesia with chlorpromazine and ether, the result was the same as the former group. By this study it was explained that these effects are not only due to less dose of anesthetic agents in combination with autonomic nerve blocking agents, but also to the rare occurrence of the cerebral anoxia, and that the hypothermia is effective to prevent brain edema in craniotomy. It is also considered that the oxygen inhalation during and after the operation may preveit the so-called brain swelling. en-copyright= kn-copyright= en-aut-name=NambaSusumu en-aut-sei=Namba en-aut-mei=Susumu kn-aut-name=難波進 kn-aut-sei=難波 kn-aut-mei=進 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=7 article-no= start-page=2321 end-page=2340 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Influences of Hypotension and Hypothermia upon the Electroencephalogram and Brain Edema Part Ⅰ. On the Influences of Hypotension upon Electroencephalogram and Brain Edema kn-title=低血圧, 低体温麻酔の脳波及び脳浮腫に及ぼす影響に関する実験的研究 第1編 低血圧麻酔の脳波及び脳浮腫に及ぼす影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Many reports have recently concerned the problems that the hypotension with autonomic nerve blocking agents are effective to prevent shock or brain edema which are often seen in craniotomy. The author studied these effects of anesthesia from the view points of electroencephalogram and brain water content. With intraperitoneal injection of 10% Dial solution for premedication, and with C(6) or Trapon as the hypotensive agents, dogs were anesthetized by endotracheal intubation with ether. In the contrast group with only Dial and ether, the increase of delta index in E.E.G. as well as that of the free and total water were seen with the lapse of time after craniotomy. In the group of hypotension (70~80 mm Hg) only with C(6) or Trapon, the increase of delta index was not seen and the brain water content showed no change. In the group of hypotension with C(6) or Trapon combined with ether anesthesia, slight decrease of delta index was seen and the brain water content showed no change. From these results, it is proved that anesthesia with simple barbiturate or ether causes anoxia of the nerve cells, resulting in brain edema and that hypotension is effective to prevent it. en-copyright= kn-copyright= en-aut-name=NambaSusumu en-aut-sei=Namba en-aut-mei=Susumu kn-aut-name=難波進 kn-aut-sei=難波 kn-aut-mei=進 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=1 article-no= start-page=233 end-page=243 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Rickettsia tsutsugamushi Ⅱ: The Complement-Fixing Antigenicity of the Peritoneal Exudate of Guinea Pigs Infected with Rickettsia tsutsugamushi, and the Infectious Protection by Vaccines from the Peritoneal Exudate kn-title=悪虫病病毒に関する研究 第2編 恙虫病病毒感染天竺鼠の腹水の補体結合反応原性と, 感染防禦賦与能に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The ascites of the guinea-pigs previously injected with chlorpromazine and then inoculated with Rickettsia tsutsugamushi was separated into two fractions, tissue and rickettsial fractions, from which formol vaccines were prepared. Each of these formol vaccines was subcutaneously injected into mice, and the relationship between infectious protecting power and complement-fixing antigenicity was investigated. In regard to the immunity, the vaccine of tissue fraction was not inferior to that of rickettsial fraction, and the complement-fixing antigenicity of each revealed no marked difference. In either vaccine of these two fractions, the immunization by a singe injection of 0.1 cc could hardly give an immunization effect against infection, and the sera of thus treated mice showed no complement fixation with the ascites of guinea-pigs containing a large amount of rickettsiae. The mice which received 2 times of injection of 0.3 cc vaccine showed a marked resistance to the attack of the homologous strain, and also a slight resistance to that of the heterologous strain. Furthermore, the complement fixation reaction using thus immunized sera and the ascites antigen of the homologous strain gave the antibody titer of 10-40×, while in the reaction with the ascites antigen of the heterologous strain the antibody titer was 10-20×. When immunized by 3 times of injection of 0.3 cc vaccine, the resistance against the attack of the homologous strain was marked and was moderate against that of the heterologous strain, and the complement fixation reaction with the sera of thus immunized mice yielded the antibody titer of 80-160× against the ascites antigen of the homologous strain and 20-160× against that of the heterologous strain. When the sera of the mice immunized by the above-mentioned vaccines show the complement fixation titer of over 20× against the ascites antigen of the homologous strain, it may be assumed that the immunized mice possess a defensive power against the rickettsial infection. en-copyright= kn-copyright= en-aut-name=NambaKazuhiko en-aut-sei=Namba en-aut-mei=Kazuhiko kn-aut-name=難波一彦 kn-aut-sei=難波 kn-aut-mei=一彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部陣内外科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=1 article-no= start-page=221 end-page=232 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Rickettsia tsutsugamushi Ⅰ: The Investigation of Immunity by means of the Seroreaction with the Flocculation Antigen and the Particle-Absorbed-Antigen kn-title=恙虫病病毒に関する研究 第1編 感染鼠肺抗原と, 微粒子吸着抗原による実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The peritoneal exudate containing a large amount of rickettsiae were obtained by intraperitoneal inoculation of Rickettsia tsutsugamushi into the guinea-pigs previously injected with chlorpromazine. The antigenic substance of thus obtained peritoneal exudate was absorbed on bentonite and pine-resin particles, and was used as the agglutination antigen. The flocculation antigen was prepared from the lung of the mice intranasally inoculated with rickettsiae. By means of the seroreaction with the use of these two sorts of antigens, the author studied the influence of the difference of the amount of rickettsiae as well as the sites of inoculation on the immunity. Intracutaneous, subcutaneous, intracerebral, intraperitoneal and intranasal routes were chosen as the sites of inoculation of living rickettsiae. The intracutaneous inoculation produced the flocculation antibodies in the largest amount, the intracerebral and subcutaneous ones the nest, and they were followed by the intraperitoneal and intranasal ones. In the case of inoculation by the routes other than nose, the antibody titer rised with the lapse of time after inoculation. When inoculated by the same route, within the range of a certain amount of rickettsiae, the difference of amount gave no influence on the production of antibodies. The agglutination reaction with the use of the particle-absorbed antigen was not feasible because of its non-special reaction. en-copyright= kn-copyright= en-aut-name=NambaKazuhiko en-aut-sei=Namba en-aut-mei=Kazuhiko kn-aut-name=難波一彦 kn-aut-sei=難波 kn-aut-mei=一彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部陣内外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1005 end-page=1009 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical Effect of Yakult (Cow's Milk Fermented by Some Sort of “Family Lactbacillaceae” Commonly Sold as a Soft Drink) Part II. Fluctuation of Vitamin B(1) in the Urine After Drinking Yakult kn-title=乳酸菌ヤクルトの臨床効果に就て（第二報）（抗結核化学療養患者に於ける変化） 其の二 市販ヤクルト飲用による尿中ビタミンB1の消長 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to determine the fluctuation of vitamin B(1) in the urine after drinking "Yakult", cow's milk fermented by some sort of "Family Lactbacillaceae", the authors made normal adults and patients with lung tuberculosis drink one bottle (60 cc) a day of Yakult successively, and estimated their content of vitamin B(1) in their urine polarographically and with paper chromatography. Results are as follows. 1. In the case of one bottle (60 cc) of Yakult successively, there occurs a little increment of vitamin B(1) content in their urine of normal adults comparing with tuberculous patients receiving chemotherapy. 2. In the case of taking one bottle of Yakult, no marked effect can be recognized in their urine of tuberculous patients receiving chemotherapy. However, when three bottles (180 cc) of Yakult are given every day, marked increase of vitamin B(1) can be observed even in their urine of the patients, and also impeding factor in polarographical estimation disappears, proving that Yakult is considerably effective in improving vitamin B(1) metabolism. en-copyright= kn-copyright= en-aut-name=NanbaHisao en-aut-sei=Nanba en-aut-mei=Hisao kn-aut-name=難波寿夫 kn-aut-sei=難波 kn-aut-mei=寿夫 aut-affil-num=1 ORCID= en-aut-name=OonisiHiroyuki en-aut-sei=Oonisi en-aut-mei=Hiroyuki kn-aut-name=大西弘之 kn-aut-sei=大西 kn-aut-mei=弘之 aut-affil-num=2 ORCID= en-aut-name=AritiSigeru en-aut-sei=Ariti en-aut-mei=Sigeru kn-aut-name=有地茲 kn-aut-sei=有地 kn-aut-mei=茲 aut-affil-num=3 ORCID= en-aut-name=MikiHukuziro en-aut-sei=Miki en-aut-mei=Hukuziro kn-aut-name=三木福治郎 kn-aut-sei=三木 kn-aut-mei=福治郎 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山県乳酸菌ヤクルト臨床研究所 affil-num=2 en-affil= kn-affil=岡山県乳酸菌ヤクルト臨床研究所 affil-num=3 en-affil= kn-affil=岡山県乳酸菌ヤクルト臨床研究所 affil-num=4 en-affil= kn-affil=岡山県乳酸菌ヤクルト臨床研究所 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=999 end-page=1004 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical Effect of Yakult (Cow's Milk Fermented by Some Sort of “Family Lactbacillaceae” Commonly Sold as a Soft Drink) Part I. Fluctuation of pH. of the Stool After Drinking Yakult kn-title=乳酸菌ヤクルトの臨床効果に就て（第二報）（抗結核化学療養患者に於ける変化） 其の一 市販ヤクルト飲用による糞便pHの変化 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the purpose to determine the fluctuation of pH. of the stool after drinking "Yakult", cow's milk fermented by some sort of "Family Lactbacillaceae", the authors made normal adults and patients with lung tuberculosis drinking one bottle (60 cc) a day of Yakult successively, and estimated the pH. of their stool colorimetrically and obtained following results. 1. In the case of normal adults taking a bottle (60 cc) of Yakult a day successively, no marked fluctuation can be recognized. 2. In the case of patients with lung tuberculosis receiving drug treatment (chemotherapy) pH. range was 6.0~7.0 namely marked difference from normal adults can be recognized. 3. In the case of patients with lung tuberculosis receiving chemotherapy, after drinking Yakult, pH. of their stool become equal with that of normal adults'. By drinking Yakult marked effect was recognized. en-copyright= kn-copyright= en-aut-name=NanbaHisao en-aut-sei=Nanba en-aut-mei=Hisao kn-aut-name=難波寿夫 kn-aut-sei=難波 kn-aut-mei=寿夫 aut-affil-num=1 ORCID= en-aut-name=OonisiHiroyuki en-aut-sei=Oonisi en-aut-mei=Hiroyuki kn-aut-name=大西弘之 kn-aut-sei=大西 kn-aut-mei=弘之 aut-affil-num=2 ORCID= en-aut-name=TanakaYosio en-aut-sei=Tanaka en-aut-mei=Yosio kn-aut-name=田中義夫 kn-aut-sei=田中 kn-aut-mei=義夫 aut-affil-num=3 ORCID= en-aut-name=MikiHukuziro en-aut-sei=Miki en-aut-mei=Hukuziro kn-aut-name=三木福治郎 kn-aut-sei=三木 kn-aut-mei=福治郎 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=医療法人謳生会病院 affil-num=2 en-affil= kn-affil=医療法人謳生会病院 affil-num=3 en-affil= kn-affil=医療法人謳生会病院 affil-num=4 en-affil= kn-affil=医療法人謳生会病院 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=389 end-page=406 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Seminal Vesiculogram in Male Sterility kn-title=男子不妊症における精嚢腺レ線像の研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Seminal vesicles were atrophied or not developed according to the lowering of the androgenic activities of the testis an I found tuberculous infection in them frequently. And it is well-known such conditions result in the disturbance of the sperm nutrition and the sperm passage which lead to the male sterility respectively. From these points, I have been, for the past seven years, observing the rentogenologic forms of semlnal vesicles about male sterility of 106 cases, and found out their morphological variations. On the classifications of seminal vesiculograms, there have been many reports, but could not be found that of seminal vesiculograms about male sterility. Then, it is intended to classify the forms of seminal vesicles of my cases as follows. 1. great main tubes with large laminated diverticula 2. great main tubes with or without small diverticula 3. simple main tubes with large laminated diverticula 4. simple main tubes with or without small diverticula 5. main tubes, dilated abnormally, demarcated poorly or irregularly, and no shaped seminal vesicles by means of the difficulties in injection of contrast medias into the vas deferens (stricture, obstruction or absence of it) The writer utilized vasopuncture of scrotal region and through the vas deferens injected Urografin and Urokolin-M into seminal vesicles. As table (2-16) shows, in seminal vesicles type No. 1 of the classification commanded a plurality (49.5%), Type No. 2 is the second (28.3%) and in Ampulla ductus deferentis, type No. 1 is first in number (60.6%) and type No. 2 next (19.2%). Seminal vesicles in male sterility are well-grown, and the angle of inclination of them have a tendency to be small (on an average 27.3 degree). Author's original classification of type No. 5 is 5.5%. But tuberculous findings in seminal vesicles are seen in few cases, on the contrary the abnormal dilatation of main tubes found frequently. en-copyright= kn-copyright= en-aut-name=NambaKatsuichi en-aut-sei=Namba en-aut-mei=Katsuichi kn-aut-name=難波克一 kn-aut-sei=難波 kn-aut-mei=克一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部泌尿器科教室 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=10 article-no= start-page=535 end-page=538 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19641030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effct of ATP on excretion of BSP in liver disease kn-title=肝疾患時のBSP色素排泄に対するALPの効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=BSP retention and hepatic blood flow were determined after administration of ATP in liver disease, and the following results were obtained. 1) 14 cases out of 22 with liver disease having, administration of ATP improved in BSP retention, and on the other hand, 8 cases of the remainder showed no changes or aggravation in that test. 2) Considerable grade of hepatic cell degeneration or necrosis was found in liver biopsy tissue of the all aggravating cases. 3) After the intravenous injection of ATP hepatic blcod flow decreased temporarily and was followed subsequently by an increase. en-copyright= kn-copyright= en-aut-name=SimadaYosihiro en-aut-sei=Simada en-aut-mei=Yosihiro kn-aut-name=島田宜浩 kn-aut-sei=島田 kn-aut-mei=宜浩 aut-affil-num=1 ORCID= en-aut-name=NambaHideki en-aut-sei=Namba en-aut-mei=Hideki kn-aut-name=難波英樹 kn-aut-sei=難波 kn-aut-mei=英樹 aut-affil-num=2 ORCID= en-aut-name=HasimotoHiroyuki en-aut-sei=Hasimoto en-aut-mei=Hiroyuki kn-aut-name=橋本宏之 kn-aut-sei=橋本 kn-aut-mei=宏之 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=10 article-no= start-page=529 end-page=534 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19641030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Significance of BSP test in differential diagnosis of jaundice kn-title=黄疸鑑別に際してのBSP試験の価値について en-subtitle= kn-subtitle= en-abstract= kn-abstract=BSP retention and serum bilirubin level were determined in cases including 51 of acute hepatitis, 19 of extrahepatic obstructive jaundice and 9 of hepatic cancer with hyperbilirubinemia. The following results were obtained. 1) There was a tendency to show some correlation between BSP and serum bilirubin level in cases of extrahepatic obstructive jaundice. On the contrary, no significant correlation between BSP retention and serum bilirubin level was found in cases of hepatocellular jaundice. 2) Hepatis cancer, showing serum bilirubin level to be approxately 2mg/dl in all cases, exhibited BSP retention at 30min. to be 15 to 30%. 3) there was no significant difference in BSP retentions between hepatocellular jaundice and extrahepatic obstructive jaundice showing same degree of serum bilirubin level in each cases. This indicates that BSP test is not useful for differential diagnosis of these types of jaundice. 4) In the cases with hepatocellular damage, a considerable amount of BSP dye was excreted through the kidney in proportion to its retention in blood. en-copyright= kn-copyright= en-aut-name=NanbaHideki en-aut-sei=Nanba en-aut-mei=Hideki kn-aut-name=難波英樹 kn-aut-sei=難波 kn-aut-mei=英樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=10 article-no= start-page=521 end-page=528 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19641030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on State of Hepatic Circulation Part 2. Determination of Hepatic Blood Flow Volume by Application of BSP and Galactose Clearance, Particularly, Review from the Viewpoint of BSP Metabolism kn-title=肝循環動態に関する研究 第2編 BSP及びガラクトースクリアランスを応用した肝血流量測定について，特にBSP代謝の面よりの検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The Calactose Continual Infusion Method devised by Nakamura et al and the BSP Continual Infusion Method reported by Bradley et al were used simultaneously on 21 chronic hepatitis and 9 hepatocirrhosis patients, and the hepatic blood flow volume was determined. The results obtained are as follows. 1) The total hepatic blood flow volume as determined by both methods were in agreement in cases with comparatively mild hepatic disturbance, but in such cases as hepatocirrhosis where abvanced cellular degeneration and necrosis were present, the value as determined by BSP method was greater than that obtained by the Galactose method. This is felt to be due to BSP clearance, particularly, the close relationship with the hepatic cell uptake capacity of BSP. 2) There is a definite difference in galactose and BSP elimination rates. The 15 cases that demonstrated a 100% elimination of galactose had BSP elimination rates which ranged from 33.0 to 84.6%, thus, in all cases the rates for the latter were lower. From these reslts, even though the BSP method may indicate a normal liver, it is felt that, there may be a hepatic shunt blood flow volume, but this is presumed to be due to the fact that the BSP up take capacity of hepatic cells is not 100% or it may be that although they have such uptake capacity, the BSP which has been taken up is again released into the blood. 3) With the use of dogs BSP in amounts less than the Maximum elimination volume of the liver was administered in succession into the peripheral vein, hepatic vein and portal vein by continual infusion, and the BSP concentration in hepatic venous blood was determined. Results showed that both the portal and hepatic venous areas were involved in the hepatic eimination of BSP. 4) Therefore, it is felt inappropriate to use BSP to determine hepatic blood flow volume in cases with hepatic disturbances. en-copyright= kn-copyright= en-aut-name=NanbaHideki en-aut-sei=Nanba en-aut-mei=Hideki kn-aut-name=難波英樹 kn-aut-sei=難波 kn-aut-mei=英樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=10 article-no= start-page=511 end-page=520 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19641030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on State of Hepatic Circulation Part 1. Relationship Between State of Hepatic Circulation and BSP Test in Hepatic Diseases kn-title=肝循環動態に関する研究 第1編 肝疾患における肝循環動態とBSP試験の関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The volume of hepatic blood flow was determined on a total of 100 hepatic diseass patients; acute hepatitis 2, chronic hepatitis 75, hepatocirrhosis 21 and fatty liver 2; by Galactose continual Infusion Method devised by Nakamura et al. At the same time, the correlation between state of hepatic circulation and BSP test was observed stochastically using as index the BSP test findings noted at time of initial out-patient examination and the BSP test find ings obtained within one week both prior to and after hepatic blood flow volume determination made following admission to the hospital. Further, comparisons were made with the hepatic tissue picture obtained by biopsy. The followresults were obtained. 1) The average value of the total hepatic blood flow Volume for the 100 hepatic disease cases was 857±46cc/min/M(2). The 49 cases with wedded hepatic venous pressure (WHVP), but without hepatic shunt flow had an average value of 135±21mm H(2)O. 2) A positive correlation with a coefficient of 0.69 was noted between WHVP and BSP test results. Further, an approximate value of 0.64 was demonstrated between the initial outpatient BSP test findings. In cases with WHVP of over 175mm H(2)O, the change-over rate to negative BSP test results following 3 to 4 weeks of hospitalization, bedrest and treatment was 13.8% , and 71.1% for those with values of less than 175mm H(2)O. 3) A negative correlation with a coefficient of -0.34 was noted between effective hepatic blood flow volume and BSP test results. Further, anegative correlation of -0.27 was demonstrated between the initial out-patient ASP test findings. In cases with an effective hepatic blood flow volume of less than 500cc/min/M(2), the change-Over rate to negative BSP test results following 3 to 4 weeks of hospitalization, bedrest and treatment was 35.0%, while that of cases with volumes of over 500cc/min/M(2) was 48.9%. 4) A positive correlation with a coefficient of 0.55 was noted between rate of hepatic short circuit and BSP test results. A positive correlation of 0.50 was demonstrated between the initial outpatient BSP test findings. In cases with hepatic short circuit, the change-over rate to negative BSP test results following 3 to 4 weeks of hospitalization, bedrest and treatment was 1%, while that in those without hepatic short circuit was 63.3%. 5) Of the 42 cases with more than a moderate degree of hepatic cell degeneration and necrosis (includes 2 cases with negative BSP test findings from the beginning), 9 cases or 22.5% demonstrated normal BSP test findings following 3 to 4 weeks of hospitalization, bedrest and treatment, while of 58 cases with slight degeneration and necrosis (includes 2 cases with normal BSP test findings from the beginning), 24 cases or 82.8% became normal during the same short period of time. 6) A follow-up BSP test survey wase conducted on 30 chronic hepatitis cases whose BSP test findings at time of discharge had become normal, and aggravations were noted in 11. Among those with aggravations, 7 or 63.5% had hepatic circulatory abnormalities during hospitalization. 7) From the above findings, it has been shown that not only degeneration and necrosis of hepatic cells are related to the BSP test value, but a relationship is also noted between the state of hepatic circulation. Therefore, it is necessary to consider both together before making any decision. en-copyright= kn-copyright= en-aut-name=NanbaHideki en-aut-sei=Nanba en-aut-mei=Hideki kn-aut-name=難波英樹 kn-aut-sei=難波 kn-aut-mei=英樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1内科教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=5-6 article-no= start-page=295 end-page=317 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evoked Cortical Responses after the Stimulation of Specific and Unspecific Nuclei of the Thalamus of the Human and Cats kn-title=ヒトおよびネコの視床核電気刺激による皮質誘発反応に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cortical evoked responses after single or repetitive stimulations of the nucleus ventralis lateralis (VL), n. centrum medianum (CM) and n. ventralis anterior (VA) were observed in 61 cases of parkinsonism, 7 cases of intractable pain and a case of dystonia musculorum deformans from February, 1968 to December, 1969. Experimental studies of the thalamic stimulations with 15 cats were performed as well and the results were compared with that of the human. Evoked responses were analysed with averaging computer technique. Results were as followings. 1) Cortical evoked potentials after single stimulation of the VL nucleus of the human thalamus. a) Evoked potentials appeared on the ipsilateral centro-frontal regions with weaker stimulation in EEG records. However, the evoked potentials showed clear bilateral distribution except the temporal region, predominantly on both centro-frontal regions, with stronger stimulation electroencephalogaphically. b) The evoked potentials of the central site showed clear three negative waves within 200 msec after the stimulation, that is, the first negative wave (Ⅰ-N) with the peak time of about 10 msec, the second (positive-) negative wave (Ⅱ-PN) with the peak time of about 50 msec and the third negative wave (Ⅲ-N) with that of 80-100 msec with averaging computer records. The peak time of the Ⅰ-N wave and the negative phase of the Ⅱ-PN wave were nearly constant, but that of the Ⅲ-N wave considerably varied according to the background activities of EEG. The evoked potentials showed no significant discrepancy between right and left patterns, and moreover, they maintained a similar pattern when the stimulating voltages were changed. c) Bilateral evoked potentials were clearly seen with averaging computer technique even when evoked potentials were small and hardly identified on the contralateral scalp with EEG records. When the stimulating voltages were gradually decreased, the ipsilateral and contralateral evoked potentials disappeared approximately at the same time. d) The latency of the Ⅰ-N wave was measured to be 5-6 msec with averaging computer records, and the amplitude of the Ⅰ-N wave increased proportionately with the increase of stimulating voltages. en-copyright= kn-copyright= en-aut-name=NambaShimpei en-aut-sei=Namba en-aut-mei=Shimpei kn-aut-name=難波真平 kn-aut-sei=難波 kn-aut-mei=真平 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学脳神経外科教室 END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=5-6 article-no= start-page=297 end-page=304 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical application of the thyrotropin releasing hormon (TRH) in various diseases kn-title=合成Thyrotropin Releasing Hormon (TRH)の臨床応用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Effect of synthetic TRH on pituitary TSH secretion in man with special reference to the evaluation for TRH test. Synthetic TSH has been administrated to 14 volunteers of euthyroid and various endocrine disorders in dose 500 μg. TRH was assessed by serial measurement of plasma TSH using radioimmunoassay with double antibody technique, serum T4 and T3. Arise in plasma TSH was observed within five minutes after intravenous administration of TRH, values of TSH reached maximum in 15 to 30 minutes in euthyroid subjects. Graded responses were obtained as the dose levels of TRH were increased. In the cases with hypothalamo-pituitary disorder including pituitary adenoma and craniopharyngioma, the TSH response to TRH in patients who showed thyroidal hypofunction was generally reduced. However, there could be observed optimal TRH induced TSH increase in hypothalamo-pituitary disorder having a euthyroid function. Almost all patients with hyperthyroidism showed no response, the plasma TSH level remaining undetectable throughout the studies, some showed a suboptimal response and a few delayed response: the plasma TSH increases only at 60 minutes. In hyperthyroidism there was no correlation between the levels of serum T4 and responseness to TRH. Primary hypothyroid patients have elevated plasma TSH levels at zero time and showed exaggerated response and the peak of TSH increase was somewhat delayed and continued. Longterm glucocorticoid treated patients and two cases of with Cushing's syndrome showed an inhibition of TSH response to TRH. en-copyright= kn-copyright= en-aut-name=YumotoYasuhiro en-aut-sei=Yumoto en-aut-mei=Yasuhiro kn-aut-name=湯本泰弘 kn-aut-sei=湯本 kn-aut-mei=泰弘 aut-affil-num=1 ORCID= en-aut-name=TanakaYoshikiyo en-aut-sei=Tanaka en-aut-mei=Yoshikiyo kn-aut-name=田中義淳 kn-aut-sei=田中 kn-aut-mei=義淳 aut-affil-num=2 ORCID= en-aut-name=NambaTuneo en-aut-sei=Namba en-aut-mei=Tuneo kn-aut-name=難波経雄 kn-aut-sei=難波 kn-aut-mei=経雄 aut-affil-num=3 ORCID= en-aut-name=MitaniTsuyoshi en-aut-sei=Mitani en-aut-mei=Tsuyoshi kn-aut-name=三谷健 kn-aut-sei=三谷 kn-aut-mei=健 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科 END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=7-8 article-no= start-page=903 end-page=911 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=19770830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Optic neuritis : Studies on the epidemiology and the cerebrospinal fluid kn-title=視神経炎に関する神経学的観察―その疫学と髄液所見― en-subtitle= kn-subtitle= en-abstract=A follow-up study on 60 previously healthy patients with nomosymptomatic optic neuritis, retrobulbar neuritis and idiopathic optic atrophy is reported. 73 per cent of the cases with insidious onset and slow progression were male, and 70 per cent of the cases who was troubled repeatedly on vision were female. In many cases, fever, common cold and overwork had precipitated the optic neuritis. During the following period, 6 patients (15.4 % of cases with acute onset) suffered from the other neurological manifestations, and a half of them (7.7 % ) were diagnosed as multiple sclerosis. Patients, who was diagnosed as retrobulbar neuritis by ophthalmoscopic examination and, who was disturbed on vision bilaterally but unsimultaneously, and repeatedly have an affinity to multiple sclerosis. At the beginning of the disease, a mononuclear pleocytosis was noted in 20.5 per cent of the patients, and elevated total protein level in 35.9 per cent. Polyacrylamide gel disc electrophoresis of the lumbar CSF proteins from 39 patients and the measurement of IgG by single radial immunodiffusion from 10 patients, were carried out. It was characteristic that the electropherogram showed the increase of pre-albumin, fast α(2)-globulin + transferrin and γ-globulin, and the decrease of albumin. These results are similar to those in multiple sclerosis. IgG and IgG % is increased in cases of retrobulbar neuritis, although total protein content is high level in optic neuritis, and then, cases who was disturbed on vision unilaterally or bilaterally but unsimultaneously showed the high level of γ-globulin. Two of 3 patients who subsequently developed to multiple sclerosis, had the CSF findings indistinguishable from those in multiple sclerosis. In one patient, CSF protein level was normal but γ-globulin was increased selectively. Another patient showed the CSF findings with slightly elevated protein level, pleocytosis and increase of IgG and IgG % . kn-abstract=原因不明のmonosymptomaticな視神経炎および視神経萎縮の60例に対し,アンケートによる初診後の経過を調べ,初診時の髄液検査(39例)の結果と合せ検討した.1)症例の発症年令は,思春期前および初老期後は著しく少なく,性別は男女同数だが,経過別にみると,緩徐発症慢性経過は男性に,急激発症反復は女性に多い.2)発症誘因に,発熱・感冒・過労などがあり, MSに類似する.3)後に神経症状を呈したのは6例で,急激発症例の15.4 % にあたる.うちMSへ移行したのは3例7.7 % である.球後視神経炎のみに限ると, 18例中3例16.7 % である.4)眼底所見,罹患側,臨床経過などを分析すると,各々,球後視神経炎,両側非同時性,急激発症反復型がMSへの指向を示す.5) 髄液では,軽度細胞数増多,軽度蛋白量増加を示す.蛋白分画ではalbuminの減少,fast α(2)-globulin＋transferrinの増加,γ-globulinの増加の他pre-albuminの増加がうかがえた.6)眼底所見別にみると,蛋白量は視神経炎で高値であるのに対し,IgG,IgG % は球後視神経炎で増加を示す.罹患側別にみると,片側性および両側非同時性においてγ-globulinの増加を認む.経過別にみると反復型およびMS移行群で,蛋白量, γ-globulinの増加を示す,又MS移行の3例中2例で,初回発作時にMS的髄液所見(γ-globulinの選択的増加, IgG, IgG % の増加)を示した. en-copyright= kn-copyright= en-aut-name=HayabaraToshiyuki en-aut-sei=Hayabara en-aut-mei=Toshiyuki kn-aut-name=早原敏之 kn-aut-sei=早原 kn-aut-mei=敏之 aut-affil-num=1 ORCID= en-aut-name=YabukiSeiso en-aut-sei=Yabuki en-aut-mei=Seiso kn-aut-name=矢吹聖三 kn-aut-sei=矢吹 kn-aut-mei=聖三 aut-affil-num=2 ORCID= en-aut-name=FukuiHideaki en-aut-sei=Fukui en-aut-mei=Hideaki kn-aut-name=福井秀明 kn-aut-sei=福井 kn-aut-mei=秀明 aut-affil-num=3 ORCID= en-aut-name=ChudaMasaki en-aut-sei=Chuda en-aut-mei=Masaki kn-aut-name=忠田正樹 kn-aut-sei=忠田 kn-aut-mei=正樹 aut-affil-num=4 ORCID= en-aut-name=NambaReiko en-aut-sei=Namba en-aut-mei=Reiko kn-aut-name=難波玲子 kn-aut-sei=難波 kn-aut-mei=玲子 aut-affil-num=5 ORCID= en-aut-name=IkedaHisao en-aut-sei=Ikeda en-aut-mei=Hisao kn-aut-name=池田久男 kn-aut-sei=池田 kn-aut-mei=久男 aut-affil-num=6 ORCID= en-aut-name=OtsukiSaburo en-aut-sei=Otsuki en-aut-mei=Saburo kn-aut-name=大月三郎 kn-aut-sei=大月 kn-aut-mei=三郎 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=国立岡山療養所・神経内科 affil-num=2 en-affil= kn-affil=高知県立中央病院・神経科 affil-num=3 en-affil= kn-affil=岡山大学・神経精神医学教室 affil-num=4 en-affil= kn-affil=岡山大学・神経精神医学教室 affil-num=5 en-affil= kn-affil=国立岡山療養所・神経内科 affil-num=6 en-affil= kn-affil=岡山大学・神経精神医学教室 affil-num=7 en-affil= kn-affil=岡山大学・神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=92 cd-vols= no-issue=11-12 article-no= start-page=1115 end-page=1121 dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=19801230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Low molecular proteins in the urine of patients with systemic lupus erythematosus Part 2. Measurement of urinary β2-microglobulin kn-title=全身性エリテマトーデスにおける尿中の低分子蛋白 第2編 尿中β2ミクログロブリンに関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By the use of radioimmunoassay, urinary β2-microglobulin concentration was mesured in 49 patients with systemic lupus erythematosus (SLE). The urinary β2-microglobulin was significantly elevated in SLE (p<0.01). The level of urinary β2-microglobulin did not correlate with the level of serum complement, antibody to DNA or the massive proteinuria. It was associated with urinary free light chain and the degree of renal tubular damage, but not with the glomerular lesions observed in renal biopsy specimens. The elevated level of β2-microglobulin in urine was most likely due to increased excretion of β2-microglobulin from involved tubulus or direct secretion from lymphocytes infiltrating the interstitium. The measurement of the level of urinary β2-microglobulin is useful for estimating the extent of renal interstitial damage in patients with SLE. en-copyright= kn-copyright= en-aut-name=NambaYoshio en-aut-sei=Namba en-aut-mei=Yoshio kn-aut-name=難波義夫 kn-aut-sei=難波 kn-aut-mei=義夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第三内科 en-keyword=全身性エリテマトーデス kn-keyword=全身性エリテマトーデス en-keyword=β2ミクログロブリン kn-keyword=β2ミクログロブリン END start-ver=1.4 cd-journal=joma no-vol=92 cd-vols= no-issue=11-12 article-no= start-page=1107 end-page=1114 dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=19801230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Low molecular proteins in the urine of patients with systemic lupus erythematosus Part 1. Measurement of urinary free light chains kn-title=全身性エリテマトーデスにおける尿中の低分子蛋白 第1編 尿中遊離light chainに関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The concentration of urinary free light chains was measured in 61 patients with systemic lupus erythematosus (SLE) by single radial immunodiffusion. The concentration was significantly increased in these patients, and was associated with hypocomplementemia and a high level of antibody to DNA. It also correlated with the clinical disease activity of SLE. It is postulated that increased free light chain in the urine of SLE patients is derived mostly from increased synthesis of light chain rather than from increased breakdown of intact immunoglobulins or decrease of catabolism during renal insufficiency. The measurement of urinary free light chains may offer information for evaluating disease activity in SLE patients. en-copyright= kn-copyright= en-aut-name=NambaYoshio en-aut-sei=Namba en-aut-mei=Yoshio kn-aut-name=難波義夫 kn-aut-sei=難波 kn-aut-mei=義夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第三内科 en-keyword=全身性エリテマトーデス kn-keyword=全身性エリテマトーデス en-keyword=遊離L鎖 kn-keyword=遊離L鎖 END start-ver=1.4 cd-journal=joma no-vol=94 cd-vols= no-issue=9-10 article-no= start-page=805 end-page=812 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19821030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=β(2)-Microglobulin in saliva and serum from patients with Sjogren's syndrome kn-title=シェーグレン病における唾液・血清β(2)ミクログロブリン値 en-subtitle= kn-subtitle= en-abstract= kn-abstract=β(2)-microglobulin is normally present in low concentrations in serum and other bodily fluids. By use of a radioimmunoassay, we measured salivary and serum β(2)-microglbulin concentrations in 40 patients with Sjogren's syndrome. The β(2)-microglobulin was significantly elevated in the saliva of patients with Sjogren's syndrome (p<0.005), but not in the serum. It was also elevated in the saliva of patients who had severe inflammatory change in the minor salivary gland, abnormal sialographic findings, reduced salivary flow rate and anti SS-A or SS-B antibody in their sera. There was no relation between the salivary , β(2)-microglobulin concentrations and the presence of various autoimmune diseases associated with Sjogren's syndrome. Measurement of salivary β(2)-microglobulin may offer a simple method of quantifying local activity in Sjogren's syndrome. en-copyright= kn-copyright= en-aut-name=NambaYoshio en-aut-sei=Namba en-aut-mei=Yoshio kn-aut-name=難波義夫 kn-aut-sei=難波 kn-aut-mei=義夫 aut-affil-num=1 ORCID= en-aut-name=KageyamaKeiko en-aut-sei=Kageyama en-aut-mei=Keiko kn-aut-name=景山ケイコ kn-aut-sei=景山 kn-aut-mei=ケイコ aut-affil-num=2 ORCID= en-aut-name=AzukizawaHideo en-aut-sei=Azukizawa en-aut-mei=Hideo kn-aut-name=小豆沢秀夫 kn-aut-sei=小豆沢 kn-aut-mei=秀夫 aut-affil-num=3 ORCID= en-aut-name=MiyawakiShoji en-aut-sei=Miyawaki en-aut-mei=Shoji kn-aut-name=宮脇昌二 kn-aut-sei=宮脇 kn-aut-mei=昌二 aut-affil-num=4 ORCID= en-aut-name=OhtaZensuke en-aut-sei=Ohta en-aut-mei=Zensuke kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=5 ORCID= en-aut-name=OfujiTadashi en-aut-sei=Ofuji en-aut-mei=Tadashi kn-aut-name=大藤眞 kn-aut-sei=大藤 kn-aut-mei=眞 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第三内科 affil-num=2 en-affil= kn-affil=岡山大学医学部第三内科 affil-num=3 en-affil= kn-affil=岡山大学医学部第三内科 affil-num=4 en-affil= kn-affil=岡山大学医学部第三内科 affil-num=5 en-affil= kn-affil=岡山大学医学部第三内科 affil-num=6 en-affil= kn-affil=岡山大学学長 en-keyword=Sjögren's syndrome kn-keyword=Sjögren's syndrome en-keyword=β(2)-microglobulin kn-keyword=β(2)-microglobulin END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=口腔細菌感染制御のための殺菌剤デリバリーシステムの研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NanbaNaoko en-aut-sei=Nanba en-aut-mei=Naoko kn-aut-name=難波尚子 kn-aut-sei=難波 kn-aut-mei=尚子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue=1-2 article-no= start-page=107 end-page=112 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Duplicate foreign bodies in the airway and gastrointestinal tract: Report of a case kn-title=気道・食道に分離した重複異物症例 ―教室異物統計と文献的考察― en-subtitle= kn-subtitle= en-abstract= kn-abstract=A case of having two or more foreign bodies simultaneously in the airway and gastrointestinal tract is rare. The authors reported a case of two foreign bodies. A 54-year-old man who carelessly swallowed thumbtacks visited our clinic. An X-ray examination revealed thumbstack in the right bronchus and another in the stomach. The former was removed with a ventilation bronchoscope, and the latter was excreted spontaneously 2 days later. The authors have experienced 84 cases of esophageal foreign bodies and 47 cases of tracheobroncheal ones in the last 10 years. Cases of foreign bodies in both locations showed a higher frequency in males, and the majority of the cases were of children 3 years old or less. Coins were the most common esophageal foreign body, and peanuts were most common tracheobroncheal foreign body.The most frequent location of the foreign bodies was the cervical constriction in cases of esophageal foreign bodies, being twice as frequent as the right bronchus. Two cases of multiple foreign bodies have been treated in our clinic, and both of them were of 2 coins in the upper esophagus. en-copyright= kn-copyright= en-aut-name=SuehiroMichio en-aut-sei=Suehiro en-aut-mei=Michio kn-aut-name=末広倫雄 kn-aut-sei=末広 kn-aut-mei=倫雄 aut-affil-num=1 ORCID= en-aut-name=UedaSetsuo en-aut-sei=Ueda en-aut-mei=Setsuo kn-aut-name=上田節夫 kn-aut-sei=上田 kn-aut-mei=節夫 aut-affil-num=2 ORCID= en-aut-name=IshiharaMotomasa en-aut-sei=Ishihara en-aut-mei=Motomasa kn-aut-name=石原基正 kn-aut-sei=石原 kn-aut-mei=基正 aut-affil-num=3 ORCID= en-aut-name=TomotsuTakao en-aut-sei=Tomotsu en-aut-mei=Takao kn-aut-name=鞆津尚夫 kn-aut-sei=鞆津 kn-aut-mei=尚夫 aut-affil-num=4 ORCID= en-aut-name=OkamotoHiroshi en-aut-sei=Okamoto en-aut-mei=Hiroshi kn-aut-name=岡本宏司 kn-aut-sei=岡本 kn-aut-mei=宏司 aut-affil-num=5 ORCID= en-aut-name=TasakaShuji en-aut-sei=Tasaka en-aut-mei=Shuji kn-aut-name=田坂周治 kn-aut-sei=田坂 kn-aut-mei=周治 aut-affil-num=6 ORCID= en-aut-name=TamuraShintaro en-aut-sei=Tamura en-aut-mei=Shintaro kn-aut-name=田村慎一郎 kn-aut-sei=田村 kn-aut-mei=慎一郎 aut-affil-num=7 ORCID= en-aut-name=NanbaMasayuki en-aut-sei=Nanba en-aut-mei=Masayuki kn-aut-name=難波正行 kn-aut-sei=難波 kn-aut-mei=正行 aut-affil-num=8 ORCID= en-aut-name=MasudaYu en-aut-sei=Masuda en-aut-mei=Yu kn-aut-name=増田游 kn-aut-sei=増田 kn-aut-mei=游 aut-affil-num=9 ORCID= en-aut-name=OguraYoshio en-aut-sei=Ogura en-aut-mei=Yoshio kn-aut-name=小倉義郎 kn-aut-sei=小倉 kn-aut-mei=義郎 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=2 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=3 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=4 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=5 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=6 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=7 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=8 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=9 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=10 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 en-keyword=気道 kn-keyword=気道 en-keyword=食道 kn-keyword=食道 en-keyword=重複異物 kn-keyword=重複異物 en-keyword=異物統計 kn-keyword=異物統計 END start-ver=1.4 cd-journal=joma no-vol=100 cd-vols= no-issue=3-4 article-no= start-page=281 end-page=293 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=1988 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Urokinase therapy for Bjork-Shiley prosthetic valve thrombosis Part II: Studies on Doppler echocardiography kn-title=Björk-Shiley弁による人工弁置換術後遠隔期の人工弁血栓症及び人工弁最大開放角制限例に対するUrokinase療法 第2編 心エコー図ドプラー法による検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Urokinase was administrated to 9 patients for the thrombolytic treatment of 10 instances of Bjork-Shiley prosthetic valve thrombosis in the mitral position. Patients were diagnosed either from clinical findings or from the maximum opening angle of the prosthetic valve. Before and after administration of urokinase, Doppler echocardiography was performed in all patients. By means of fibrionlytic treatment, the peak velocity of rapid filling into the left ventricle, the peak pressure gradient, the pressure half time and the mean diastolic gradient decreaed, while the effective valve area increased. It was considered that thrombolytic tretment with urokinase is effective for Bjork-Shiley prosthetic valve thrombosis, en-copyright= kn-copyright= en-aut-name=NambaHirofumi en-aut-sei=Namba en-aut-mei=Hirofumi kn-aut-name=難波宏文 kn-aut-sei=難波 kn-aut-mei=宏文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=Björk-Shiley弁 kn-keyword=Björk-Shiley弁 en-keyword=Urokinase療法 kn-keyword=Urokinase療法 en-keyword=人工弁血栓症 kn-keyword=人工弁血栓症 en-keyword=人工弁最大開放角線溶療法 kn-keyword=人工弁最大開放角線溶療法 en-keyword=心エコー図ドプラー法 kn-keyword=心エコー図ドプラー法 END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue=2 article-no= start-page=61 end-page=67 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=19920328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Preparation of Mullite Dispersed Silica Ceramics through Sol-Gel Processing en-subtitle= kn-subtitle= en-abstract= kn-abstract=Mullite-dispersed silica ceramics were prepared through sol-gel processing by the use of tetraethoxy silane, aluminium nitrate and aluminium isopropoxide as the Si and Al sources where HCl and HN0(3) were the catalyst. Effect of the starting materials, solvents and catalysts was examined on the gelation time or temperature of mullite precipitation. Apparent activation energy of gelation ranged from 80 to 95kJ/mol. The presence of AI in the sols elongated the gelling time suggesting the formation of chelate bonds between AI and Si-OR or Si-OH bonds. en-copyright= kn-copyright= en-aut-name=OsakaAkiyoshi en-aut-sei=Osaka en-aut-mei=Akiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=KawabataKouji kn-aut-sei=Kawabata kn-aut-mei=Kouji aut-affil-num=2 ORCID= en-aut-name=NanbaTokuro en-aut-sei=Nanba en-aut-mei=Tokuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakadaJun en-aut-sei=Takada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiuraYoshinari en-aut-sei=Miura en-aut-mei=Yoshinari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Applied Chemistry affil-num=2 en-affil= kn-affil=Industrial Technology Center of Okayama Prefecture affil-num=3 en-affil= kn-affil=Department of Applied Chemistry affil-num=4 en-affil= kn-affil=Department of Applied Chemistry affil-num=5 en-affil= kn-affil=Department of Applied Chemistry END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue=2 article-no= start-page=69 end-page=75 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=19920328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Preparation and Characterization of Ti(2)O(3) Films Deposited on Sapphire Substrate by Activated Reactive Evaporation Method en-subtitle= kn-subtitle= en-abstract= kn-abstract=(001)-oriented Ti(2)O(3) films were epitaxially grown on a(001)-face of sapphire single-crystalline substrate by an activated reactive evaporation method. The formation ranges of stoichiometric and nonstoichiometric Ti(2)O(3) films were determined as a function of the substrate temperature (Ts), the oxygen pressure (Po(2)) and the deposition rate. Stoichiometric Ti(2)O(3) films were grown at Ts≧673K under Po(2)≧1.0×10(-4)Torr, which showed the metal-insulator transition with a sharp change in electrical resistivity from 3.5×10(-2) to 2.6×10(-3)Ωcm at 361K. Nonstoichiometric films prepared under less oxidized conditions did not exhibit the transition. The nonstoichiometry of the Ti(2)O(3)films was discussed in terms of excess Ti ions. en-copyright= kn-copyright= en-aut-name=FujiiTatsuo en-aut-sei=Fujii en-aut-mei=Tatsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=SakataNaoki kn-aut-sei=Sakata kn-aut-mei=Naoki aut-affil-num=2 ORCID= en-aut-name=NanbaTokuro en-aut-sei=Nanba en-aut-mei=Tokuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OsakaAkiyoshi en-aut-sei=Osaka en-aut-mei=Akiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiuraYoshinari en-aut-sei=Miura en-aut-mei=Yoshinari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakadaJun en-aut-sei=Takada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Department of Applied Chemistry affil-num=2 en-affil= kn-affil=Department of Applied Chemistry affil-num=3 en-affil= kn-affil=Department of Applied Chemistry affil-num=4 en-affil= kn-affil=Department of Applied Chemistry affil-num=5 en-affil= kn-affil=Department of Applied Chemistry affil-num=6 en-affil= kn-affil=Department of Applied Chemistry END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=2 article-no= start-page=67 end-page=75 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Examination of informed consent to preoperative esophagus cancer patient kn-title=食道がん患者に対する術前インフォームド･コンセントの検討 en-subtitle= kn-subtitle= en-abstract=It is important for the patients with esophageal cancer to receive truth telling about their illness as well as to have informed consent fully concerning treatment method when making self-decision. There have been few reports about the self-decision oriented informed consent which were analyzed with qualitative induction research. We therefore conducted qualitative research using semi-structured questionnaire to elucidate how an informed consent should be conducted to support the patients to make self-decision for accepting surgical treatment. As results, 1. Informed consent should not be an event but a process according to capacity of the patients for understanding their own illness. 2. Explanation about the condition following an operation, especially about the symptom or the procedure causing pain, should be supportive for the patients with picturing a specific image, considering the personality of the patients. 3. Supportive system for patients after receiving informed consent and making a decision accepting surgical treatment should be improved because of insufficient sharing of information among medical team members. kn-abstract=食道がん患者が食道切除術を受けることを自己決定する場合には,食道癌であることの告知と､食道癌に対する治療方法に関するインフォームド･コンセントが重要となる｡食道がん患者の治療法選択における自己決定を指向したインフォームド･コンセントの有り様について,質的帰納的に分析した文献は少ない｡今回,食道がん患者に対して,半構成的質問用紙を用いて,面接を実施することで,患者が治療法として手術を自己決定するために役立つインフォームド･コンセントとはどのようにあればいいかを明らかにした｡その結果,患者が食道切除術を受けることを決めるためには,①患者の理解度にあわせ,何度かに分けてインフォームド･コンセントが行われる必要があること,②術後に起こってくる症状,特に患者にとって苦痛を伴う検査,処置等については,患者のパーソナリティーを考えながら,術後のイメージがわくような説明が必要であること,③患者の自己決定に至る過程のみならず,インフォームド･コンセント後においても,患者や家族を支援する体制が重要であること,が明らかになった｡ en-copyright= kn-copyright= en-aut-name=MoriKeiko en-aut-sei=Mori en-aut-mei=Keiko kn-aut-name=森恵子 kn-aut-sei=森 kn-aut-mei=恵子 aut-affil-num=1 ORCID= en-aut-name=KanaoNaomi en-aut-sei=Kanao en-aut-mei=Naomi kn-aut-name=金尾直美 kn-aut-sei=金尾 kn-aut-mei=直美 aut-affil-num=2 ORCID= en-aut-name=NanbaKayo en-aut-sei=Nanba en-aut-mei=Kayo kn-aut-name=難波佳代 kn-aut-sei=難波 kn-aut-mei=佳代 aut-affil-num=3 ORCID= en-aut-name=IshikawaTakako en-aut-sei=Ishikawa en-aut-mei=Takako kn-aut-name=石川貴子 kn-aut-sei=石川 kn-aut-mei=貴子 aut-affil-num=4 ORCID= en-aut-name=SaitoShinya en-aut-sei=Saito en-aut-mei=Shinya kn-aut-name=斎藤信也 kn-aut-sei=斎藤 kn-aut-mei=信也 aut-affil-num=5 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 affil-num=2 en-affil= kn-affil=国立病院四国がんセンター affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院西病棟3階 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院西病棟3階 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院消化器･腫瘍外科 affil-num=6 en-affil= kn-affil=岡山大学医歯学総合研究科消化器･腫瘍外科 en-keyword=インフォームド･コンセント (Informed consent) kn-keyword=インフォームド･コンセント (Informed consent) en-keyword=食道がん (esophagus cancer) kn-keyword=食道がん (esophagus cancer) en-keyword=治療法の選択 (selecting treatment method) kn-keyword=治療法の選択 (selecting treatment method) en-keyword=自己決定 (self-determination) kn-keyword=自己決定 (self-determination) END start-ver=1.4 cd-journal=joma no-vol=28 cd-vols= no-issue= article-no= start-page=28 end-page=33 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=200612 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on optical properties of SnO-based glasses as lead-free glasses kn-title=SnOベースガラスの鉛代替光学ガラスへの応用の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The preparation of SnO-SiO(2), SnO-B(2)O(3), and SnO-GeO(2) glasses by melting in air was performed. The prepared SnO-GeO(2) glasses were large enough to measure optical properties whereas the vitrification in SnO-SiO(2) and SnO-B(2)O(3) systems was difficult. PbO-GeO(2) and BiO(1.5)-GeO(2) glasses were also prepared for comparison with SnO-GeO(2) glasses. The densities, glass transition temperatures, and optical properties such as refractive indices, dispersion, and transmission spectra of SnO-GeO(2), PbO-GeO(2), and BiO(1.5)-GeO(2) glasses were measured. On the basis of the results, the potential for SnO-GeO(2) glasses as lead-free glasses is particularly discussed from the viewpoint of optical properties. en-copyright= kn-copyright= en-aut-name=SakidaShinichi en-aut-sei=Sakida en-aut-mei=Shinichi kn-aut-name=崎田真一 kn-aut-sei=崎田 kn-aut-mei=真一 aut-affil-num=1 ORCID= en-aut-name=MasudaKoichi en-aut-sei=Masuda en-aut-mei=Koichi kn-aut-name=増田紘一 kn-aut-sei=増田 kn-aut-mei=紘一 aut-affil-num=2 ORCID= en-aut-name=NanbaTokuro en-aut-sei=Nanba en-aut-mei=Tokuro kn-aut-name=難波徳郎 kn-aut-sei=難波 kn-aut-mei=徳郎 aut-affil-num=3 ORCID= en-aut-name=MiuraYoshinari en-aut-sei=Miura en-aut-mei=Yoshinari kn-aut-name=三浦嘉也 kn-aut-sei=三浦 kn-aut-mei=嘉也 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学保健環境センター環境安全部門 affil-num=2 en-affil= kn-affil=岡山大学環境理工学部環境物質工学科 affil-num=3 en-affil= kn-affil=岡山大学環境理工学部環境物質工学科 affil-num=4 en-affil= kn-affil=岡山大学環境理工学部環境物質工学科 en-keyword=SnO-based glasses kn-keyword=SnO-based glasses en-keyword=Lead-free glasses kn-keyword=Lead-free glasses en-keyword=Refractive indices kn-keyword=Refractive indices en-keyword=Dispersion kn-keyword=Dispersion en-keyword=Transmittance kn-keyword=Transmittance en-keyword=Optical properties kn-keyword=Optical properties END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue= article-no= start-page=11 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200710 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Material recycling of blast furnace slag by phase separation of glass kn-title=ガラスの分相現象を利用した高炉水砕スラグの再資源化技術の開発 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A novel recycling process of blast furnace slag was developed in order to obtain colorless silica-rich solids by using phase separation of borosilicate glass. B(2)O(3) was added to blast furnace slag to promote the phase separation. The slag glasses were heat-treated above glass transition temperatures. The slag glass prepared from blast furnace slag gelled after the heat treatment and the subsequent three types of acid treatment. The ratios of SiO(2) component in the gels were 40 – 60mass%. On the other hand, phase separation was observed on the surface of the slag glasses prepared from pre-treated slag by 2.5N HCl after the heat treatment. After soaking in acid, they did not gel and changed to insoluble colorless solids. According to compositional analyses, it was found that the insoluble colorless solids contained 70 - 90mass% SiO(2). No colored ions such as Cr, Mn, and Fe were confirmed in the remaining insolubles by optical absorption measurement. Therefore, the colorless silica-rich solids were successfully obtained in the present process. The end products obtained in the present process are expected as material of glass. en-copyright= kn-copyright= en-aut-name=SakidaShinichi en-aut-sei=Sakida en-aut-mei=Shinichi kn-aut-name=崎田真一 kn-aut-sei=崎田 kn-aut-mei=真一 aut-affil-num=1 ORCID= en-aut-name=MikamiSyuuhei en-aut-sei=Mikami en-aut-mei=Syuuhei kn-aut-name=三上修平 kn-aut-sei=三上 kn-aut-mei=修平 aut-affil-num=2 ORCID= en-aut-name=NanbaTokuro en-aut-sei=Nanba en-aut-mei=Tokuro kn-aut-name=難波徳郎 kn-aut-sei=難波 kn-aut-mei=徳郎 aut-affil-num=3 ORCID= en-aut-name=MiuraYoshinari en-aut-sei=Miura en-aut-mei=Yoshinari kn-aut-name=三浦嘉也 kn-aut-sei=三浦 kn-aut-mei=嘉也 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学保健環境センター環境安全部門 affil-num=2 en-affil= kn-affil=岡山大学環境理工学部環境物質工学科 affil-num=3 en-affil= kn-affil=岡山大学環境理工学部環境物質工学科 affil-num=4 en-affil= kn-affil=岡山大学環境理工学部環境物質工学科 en-keyword=Blast furnace slag kn-keyword=Blast furnace slag en-keyword=Recycling kn-keyword=Recycling en-keyword=Colorless silica-rich solids kn-keyword=Colorless silica-rich solids en-keyword=Phase separation kn-keyword=Phase separation en-keyword=Glass kn-keyword=Glass END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=3-4 article-no= start-page=299 end-page=308 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199004 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical and experimental studies on provocating and reducing mechanism of intractable pain Part 2. β-endorphin and monoamine metabolites in CSF of the patient with chronic pain -comparison of the concentration between pre- and post-stimulation of CNS kn-title=頑痛の発生および抑制に関する基礎的・臨床的研究 第2編 頑痛患者に於ける髄液中 β-endorphin および monoamine 代謝産物―中枢神経系の電気刺激前後に於ける濃度変動について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=The concentration of β-endorphin-immunoreactivity (β-END-IR) and monoamine metabolites which are 3-methoxy-4-hydroxy-phenylglycol (MHPG), homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA) were measured in cerebrospinal fluid (CSF) of patients with intractable pain to estimate the participation of these substances in the mechanism of intractable pain. The amount of β-END-IR and monoamine metabolites was measured with radioimmunoas-say and HPLC (hight performance liquid chromatography), respectively. Eight cases of intractable pain were treated with impantation of the stimulating electrode for pain relief. This treatment was performed in 2 ways, deep brain stimulation (DBS) done on 6 cases and spinal dorsal column stimualtion (DCS) on 2 cases. The concentrations of β-END-IR and monoamine metabolites were also estimated before and after the stimulation. No patient treated with DBS showed the elevation of β-END-IR or monoamine metabolites after the stimulation, except for one patient who showed significant increase of monoamine metabolites accompanying excellent pain relief by the stimulation. On the other hand, the two patients treated with DCS indicated significant elevation of β-END-IR as well as monoamine metabolites. Thus, both β-END and monoamines could play as important role DCS, and that monoamine could be involved in DBS for pain relief. en-copyright= kn-copyright= en-aut-name=FujiwaraNoriaki en-aut-sei=Fujiwara en-aut-mei=Noriaki kn-aut-name=藤原則章 kn-aut-sei=藤原 kn-aut-mei=則章 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳神経外科教室 en-keyword=β-endorphin kn-keyword=β-endorphin en-keyword=monoamine kn-keyword=monoamine en-keyword=pain kn-keyword=pain en-keyword=CSF kn-keyword=CSF en-keyword=stimulation of CNS kn-keyword=stimulation of CNS END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=3-4 article-no= start-page=287 end-page=297 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199004 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical and experimental studies on provocating and reducing mechanism of intractable pain Part 1. Experimental study on significance of changes of substance P and enkephalin concentrations in subnucleus caudalis of spinal trigeminal neucleus (STN) in cat kn-title=頑痛の発生および抑制に関する基礎的・臨床的研究 第1編 三叉神経脊髄路尾側亜核におけるサブスタンス P およびエンケファリン濃度変動の意義に関する基礎的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The possible role of substance P (SP) and enkephalin (ENK) was investigated in the mechanism of deafferented pain (DP) and excess pain. The concentration of SP anf ENK was quantitatively estimated with radioimmunoassay using 17 adults cats. The animal were divided into 3 group, DP group (8 cats), EP group (6 cats) and untreated conrol group (3 cats). The DP group was prepared according to the method described by Shimizu and EP model was made by injection 1 ml of Freund's adjuvant subcutaneously into the unilateral face of the cats every day for 3 weeks. The amount of SP in STN markedly decreased in DP group and significantly higher in EP group than with the control group. This is explained by the fact that SP is a neurotransmitter for pain of trigeminal nerve. No significant decrease in ENK in the DP group was observed. This suggests that ENK in STN is not always controlled by the descending inhibitory system, but may be working in the propriospinal system. ENK in the EP group also showed no significant increase. This can be explained not only by the difficulty in estimating the rapid degeneration of ENK, but also by the strong participation of monoamines as well as ENK in pain relief. The role of ENK should not be overstimated and the studies including monoamines will be necessary to detemine the mechanism of pain. en-copyright= kn-copyright= en-aut-name=FujiwaraNoriaki en-aut-sei=Fujiwara en-aut-mei=Noriaki kn-aut-name=藤原則章 kn-aut-sei=藤原 kn-aut-mei=則章 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳神経外科教室 en-keyword=substance P kn-keyword=substance P en-keyword=enkephalin kn-keyword=enkephalin en-keyword=pain kn-keyword=pain en-keyword=RIA kn-keyword=RIA END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=39 end-page=44 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=鉛フリー光学ガラスとしてのSnO-B(2)O(3)ガラスの光学特性 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The preparation of SnO-B(2)O(3) and SnO-SiO(2) glasses by melting in Ar atomosphere was performed. The prepared SnO-B(2)O(3) glasses were large enough to measure optical properties whereas the vitrification in SnO-SiO(2) system was very difficult. PbO-B(2)O(3) and BiO1.5-B(2)O(3) glasses were also prepared for comparison with SnO-B(2)O(3) glasses. The densities, glass transition temperatures, and optical properties such as refractive indices, dispersion, and transmission spectra of SnO-B(2)O(3), PbO-B(2)O(3), and BiO(1.5)-B(2)O(3) glasses were measured. On the basis of the obtained results, the potential for SnO-B(2)O(3) glasses as lead-free glasses is particularly discussed from the viewpoint of optical properties. en-copyright= kn-copyright= en-aut-name=SakidaShinichi en-aut-sei=Sakida en-aut-mei=Shinichi kn-aut-name=崎田真一 kn-aut-sei=崎田 kn-aut-mei=真一 aut-affil-num=1 ORCID= en-aut-name=NanbaTokuro en-aut-sei=Nanba en-aut-mei=Tokuro kn-aut-name=難波徳郎 kn-aut-sei=難波 kn-aut-mei=徳郎 aut-affil-num=2 ORCID= en-aut-name=MiuraYoshinari en-aut-sei=Miura en-aut-mei=Yoshinari kn-aut-name=三浦嘉也 kn-aut-sei=三浦 kn-aut-mei=嘉也 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学環境管理センター affil-num=2 en-affil= kn-affil=岡山大学環境理工学部環境物質工学科 affil-num=3 en-affil= kn-affil=岡山大学環境理工学部環境物質工学科 en-keyword=SnO-B(2)O(3) glasses kn-keyword=SnO-B(2)O(3) glasses en-keyword=Lead-free glasses kn-keyword=Lead-free glasses en-keyword=Refractive indices kn-keyword=Refractive indices en-keyword=Dispersion kn-keyword=Dispersion en-keyword=Transmittance kn-keyword=Transmittance en-keyword=Optical properties kn-keyword=Optical properties END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=4 article-no= start-page=411 end-page=418 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Seasonal prevalence of mosquitoes and incidence of Japanese B encephalitis in Kochi City and south-western area of Kochi Prefecture kn-title=高知県の西南地域と高知市におけるコガタアカイエカの季節的消長と日本脳炎患者発生状況 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Adults mosquitoes of Culex tritaeniorhynchus were collected by light traps in a pigsty at Kochi City located in the central Kochi Prefecture and that at Tosashimizu City located in the southern Kochi Prefecture from 1965 to 1972. A marked difference was observed in seasonal fluctuation of mosquito population between the two sites of collection. During the period of observation, the incidence of Japanese encephalitis patients fluctuated in parallel with the average population of mosquitoes collected from June to September. The first incidnece of Japanese encephalitis patients in Kochi Prefecture generally starts from south-western Kochi Prefecture including Tosashimizu City and gradually moves north. This is coincident with the trend observed in the appearance of the first mosquito population in these area. en-copyright= kn-copyright= en-aut-name=MatsuzakiSawako en-aut-sei=Matsuzaki en-aut-mei=Sawako kn-aut-name=松崎沙和子 kn-aut-sei=松崎 kn-aut-mei=沙和子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=高知女子大学家政学部生活生物学教室 en-keyword=mosquito kn-keyword=mosquito en-keyword=Culex tritaeniorhynchus kn-keyword=Culex tritaeniorhynchus en-keyword=light trap kn-keyword=light trap en-keyword=Japanese encephalitis kn-keyword=Japanese encephalitis en-keyword=Kochi Prefecture kn-keyword=Kochi Prefecture END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=4 article-no= start-page=387 end-page=397 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the lymphocyte function bronchial asthma Part 1. Examination of lymphocyte responsiveness with inhalation antigens of bronchial asthma kn-title=気管支喘息におけるリンパ球機能に関する研究 第1編 気管支喘息におけるBAL 液中並びに末梢血中リンパ球の吸入抗原に対する幼若化反応の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Various antigens such as mite and fungi have been known to provoke bronchoconstriction in patients with bronchial asthma. The allergic mechanisms of asthmatic attack induced by these antigens were analyzed to clarify the role of cellular immunity in the pathogenesis of bronchial asthma. Mite and Candida antigens were applied to lymphocyte blastogenesis in asthmatic patients. Both lymphocytes in bronchoalveolar lavage fluid (BALF) and in peripheral blood of asthmatic patients responded significantly to mite and Candida antiten. Furthermore, BALF lymphocytes of patients with non-atopic and intractable asthma showed higher responses against Candida antigen than those of patients with atopic and non-intractable asthma, while peripheral blood lymphocytes showed a higher response against mite antigen in patients with atopic and non-intractable asthma. These findings indicate that lymphocytes in lugns sensitized with Candida antigen might play an important role in the pathogenesis of non-atopic and intractable asthma. en-copyright= kn-copyright= en-aut-name=TakadaSho en-aut-sei=Takada en-aut-mei=Sho kn-aut-name=武田昌 kn-aut-sei=武田 kn-aut-mei=昌 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=リンパ球幼若化反応 kn-keyword=リンパ球幼若化反応 en-keyword=bronchoalveolar lavage kn-keyword=bronchoalveolar lavage en-keyword=Candida kn-keyword=Candida en-keyword=mite kn-keyword=mite END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=11-12 article-no= start-page=1171 end-page=1176 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Tumor lysis syndrome after the effective chemotherapy in a patient with recurrence of colon cancer kn-title=癌化学療法が奏効し Tumor Lysis Syndrome を呈した結腸癌再発症例の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A case of recurrence of colon cancer with marked tumor reduction after effective chemotherapy is reported. The patient was a 27-years-old female who was admitted to the 1st department of surgery because of a giant abdominal tumor. She had undergone surgery for cecal cancer 16 months before admission. Abdominal and pelvic CT-SCAN revealed a giant tumor (21×18cm) invading the rectum and uterus. Surgical cannulation was performed into bilateral internal iliac arteries, and anti-cancer drugs (5-FU : 5000mg, ADR : 40mg, CDDP : 200mg) were administered intraarterially. The occurrence of hyperkalemia and striking rises in LDH, CEA, CA19-9 after the chemotherapy strongly suggested the tumor lysis syndrome, which to our knowledge, has not been reported as a complication of the treatment of colon carcinoma. en-copyright= kn-copyright= en-aut-name=InoguchiKazuhito en-aut-sei=Inoguchi en-aut-mei=Kazuhito kn-aut-name=井口利仁 kn-aut-sei=井口 kn-aut-mei=利仁 aut-affil-num=1 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=2 ORCID= en-aut-name=HamanakaSohei en-aut-sei=Hamanaka en-aut-mei=Sohei kn-aut-name=浜中荘平 kn-aut-sei=浜中 kn-aut-mei=荘平 aut-affil-num=3 ORCID= en-aut-name=MoreiraLuis Fernando en-aut-sei=Moreira en-aut-mei=Luis Fernando kn-aut-name=モレイラルイス・フエルナンド kn-aut-sei=モレイラ kn-aut-mei=ルイス・フエルナンド aut-affil-num=4 ORCID= en-aut-name=NanbaHiroshi en-aut-sei=Nanba en-aut-mei=Hiroshi kn-aut-name=難波浩 kn-aut-sei=難波 kn-aut-mei=浩 aut-affil-num=5 ORCID= en-aut-name=OkabayashiTakahiro en-aut-sei=Okabayashi en-aut-mei=Takahiro kn-aut-name=岡林孝弘 kn-aut-sei=岡林 kn-aut-mei=孝弘 aut-affil-num=6 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=7 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=Tumor Lysis Syndrome kn-keyword=Tumor Lysis Syndrome en-keyword=結腸癌再発 kn-keyword=結腸癌再発 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=1-2 article-no= start-page=183 end-page=197 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental study on pathogenesis and treatment of cerebral vasospasm Part 2. Effects of PGI2 analogue, thromboxane A2 synthetase inhibitor and Ca blocker on experimental delayed spasm models kn-title=脳血管攣縮の発生機序と治療に関する実験的研究 第2編 実験的遅発性脳血管攣縮に対する PGI2 analogue, Thromboxane A2 合成酵素阻害剤, Ca 拮抗剤の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effects of a PGI2 analogue (OP-41483), a thromboxane A2 synthetase inhibitor (OKY-046) and a Ca blocker (nifedipine) on the diameter of constricted basilar arteries and on the regional cerebral blood flow (r-CBF) in the brain stem were investigated in the cat delayed spasm model. The experiment was performed three days (72 hours) after artificial subarachnoid hemorrhage. The basilar artery was exposed transclivally, and more advanced vasospasm was produced by topical application of a lysed erythrocyte solution for 5 to 6 hours which domonstrated no more vascular dilatation even by topical application of papaverine hydrochloride (0.01mg/ml). In the delayed spasm model, the intravenous administration of neither OP-41483 (8μg/kg), OKY-046 (60mg/kg) nor nifedipine (0.003mg/kg) affected the vascular diameter. OP-41483 increased r-CBF in the brain stem in 3, and nifedipine increased it in 4 out of the 5 studied delayed spasm models, whereas OKY-046 never increased r-CBF (n=5). There was no significant difference in the amount of fatty acids including arachidonic acid between normal and constricted arteries. This study suggested that thromboxane A2 is not the major factor of cerebral vasospasm and OKY-046 might not be effective on vascular diameter or r-CBF at the late spasm stage. However, the PGI2 analogue (OP-41483) and Ca blocker (nifedipine) may be effective in increasing r-CBF even at the late spasm stage. en-copyright= kn-copyright= en-aut-name=MotokiMototsugu en-aut-sei=Motoki en-aut-mei=Mototsugu kn-aut-name=元木基嗣 kn-aut-sei=元木 kn-aut-mei=基嗣 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳神経外科教室 en-keyword=cerebral vasospasm kn-keyword=cerebral vasospasm en-keyword=thromboxane A2 kn-keyword=thromboxane A2 en-keyword=OP-41483 kn-keyword=OP-41483 en-keyword=OKY-046 kn-keyword=OKY-046 en-keyword=nifedipine kn-keyword=nifedipine END start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue=1 article-no= start-page=39 end-page=45 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=200902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Measurement and Analysis of Fog Flow in Plastic Greenhouse kn-title=温室における煙霧流の測定と解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper deals with measurement and analysis of fog flow in a greenhouse. In this study we applied a gas-liquid two phase flow spray and a pesticide spray using new technology such as a non-heating fog carrier, in order to prevent desease and insects in agricultural operations. Spray particle density was analyzed by a new method using an air sampler, and the behavior of fog particles in the space was studied. The following results were obtained, 1. The spray particles were within a size of 15 ~ 30μm and the behavior of these particles were clarified in this experiment. 2. The floating time after spray of particles, and the diffusing performance of spray particles in the greenhouse were clearly observed, tracked and recorded in this experiment. 3. Effective methods of pesticide application in greenhouse were discovered in this study. en-copyright= kn-copyright= en-aut-name=TangBomin en-aut-sei=Tang en-aut-mei=Bomin kn-aut-name=湯伯敏 kn-aut-sei=湯 kn-aut-mei=伯敏 aut-affil-num=1 ORCID= en-aut-name=MohriKentaro en-aut-sei=Mohri en-aut-mei=Kentaro kn-aut-name=毛利建太郎 kn-aut-sei=毛利 kn-aut-mei=建太郎 aut-affil-num=2 ORCID= en-aut-name=MontaMitsuji en-aut-sei=Monta en-aut-mei=Mitsuji kn-aut-name=門田充司 kn-aut-sei=門田 kn-aut-mei=充司 aut-affil-num=3 ORCID= en-aut-name=NambaKazuhiko en-aut-sei=Namba en-aut-mei=Kazuhiko kn-aut-name=難波和彦 kn-aut-sei=難波 kn-aut-mei=和彦 aut-affil-num=4 ORCID= en-aut-name=IwasakiMasami en-aut-sei=Iwasaki en-aut-mei=Masami kn-aut-name=岩崎正美 kn-aut-sei=岩崎 kn-aut-mei=正美 aut-affil-num=5 ORCID= en-aut-name=QiuBai-jing en-aut-sei=Qiu en-aut-mei=Bai-jing kn-aut-name=邱白 kn-aut-sei=邱 kn-aut-mei=白 aut-affil-num=6 ORCID= en-aut-name=LiangJian en-aut-sei=Liang en-aut-mei=Jian kn-aut-name=梁建 kn-aut-sei=梁 kn-aut-mei=建 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=中国農業部南京農業機械化研究所 affil-num=2 en-affil= kn-affil=岡山大学名誉教授 affil-num=3 en-affil= kn-affil=環境生態学コース affil-num=4 en-affil= kn-affil=環境生態学コース affil-num=5 en-affil= kn-affil=鳥取大学 affil-num=6 en-affil= kn-affil=中国江蘇大学 affil-num=7 en-affil= kn-affil=中国農業部南京農業機械化研究所 en-keyword=egg kn-keyword=egg en-keyword=food allergy kn-keyword=food allergy en-keyword=IgE kn-keyword=IgE en-keyword=mast cells kn-keyword=mast cells END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=1-2 article-no= start-page=147 end-page=159 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Neurophysiological study of deep brain stimulation for the treatment of deafferentation pain Part 2. Usefulness of deep cerebral sensory evoked potentials (SEP) for assessment of traget points in the lemniscal system kn-title=Deafferentation pain に対する脳深部刺激療法の研究 第2編― 内側毛帯系刺激における除痛点の脳深部知覚誘発反応（SEP）による評価について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=To relieve deafferentation pain, electrophysiological assessment of target points was performed using deep cerebral SEPs. As a preliminary experiment, the relationship between the waveform of the SEP and the anatomical structure of the brain was examined in cats. The infraorbital nerve was stimulated and the SEP was recorede around the VPM. From the rostral edge of the medial leminiscus (ML), a high voltage positive wave was recorded, and from the ventral side of the VPM a wide negative wave with positive wavelets was recorded. For the treatment of three cases of thalamic pain, the deep cerebral SEP was recorded during the insertion of a chronic electrode for deep brain stimulation. By contralateral median nerve stimulation, the high voltage posotive waves (peak latency ; 13-15msec) from the ML and the subsequent unerven waves from the VPL were recorded along the trajectory. The later uneven waves were composed of wide negative waves and positive wavelets, which were thought to be derived from the synaptic activity of the VPL and thalamocortical rediation, respectively. Effective pain relief was obtained at the border zone of the ventral VPL and the ML, where the characteristic waves of the VPL changed to those of the ML. The deep cerebral SEP can be used for the identification of target points electrophysiologically. en-copyright= kn-copyright= en-aut-name=TomitaSusumu en-aut-sei=Tomita en-aut-mei=Susumu kn-aut-name=富田享 kn-aut-sei=富田 kn-aut-mei=享 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳神経外科学教室 en-keyword=deafferentation pain kn-keyword=deafferentation pain en-keyword=deep brain stimulation kn-keyword=deep brain stimulation en-keyword=sensory evoked potential kn-keyword=sensory evoked potential en-keyword=leminiscus medialis kn-keyword=leminiscus medialis en-keyword=nucleus ventrocaudalis kn-keyword=nucleus ventrocaudalis END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=1-2 article-no= start-page=129 end-page=146 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Neurophysiological study of deep brain stimulation for the treatment of deafferentation pain Part 1. Influence of neurotransmitters upon deafferentation hyperactivity in cats -Participation of GABA in the descending inhibitory system- kn-title=Deafferentation pain に対する脳深部刺激療法の研究 第1編― Deafferentation hyperactivity に対する神経伝達物質の影響及び下行性抑制系との関係について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Deafferentation hyperactivity (DH) was provoked in the neurons of the subnucleus caudalis of the spinal trigeminal nucleus and the lateral reticular formation in cats by Gasserian ganglionectomy, and was used as a model of peripheral deafferentation pain. The influence of neurochemical substances upon DH was investigated. Neurotransmitters and their antagonists were applied topically around the soma of hyperactive neruons by the microiontophoretic technique, using a 7-barreled glass micropipette. Then the participation of inhibitory amino acids in the descending inhibitory systems, which were activated by deep brain stimulation (DBS), was investigated. Discharges of hyperactive neurons (n=75) were recorded extracellularly and analyzed using a spike density histogram. DH was suppressed by topically injected GABA and glycine, but not by met-enkephalin. The suppressive effects of GABA and glycine were almost completely antagonized by bicuculline and strychnine, respectively. Stimulation of the internal capsule or VPM suppressed DH, and this suppression was not affected by microiontophoretically injected bicuculline or strychnine. Intravenous injection of picrotoxin reduced the suppression, but intravenous strychnine did not. GABA may play an important role as an inhibitory neurotransmitter in the descending inhibitory systems activated by DBS. en-copyright= kn-copyright= en-aut-name=TomitaSusumu en-aut-sei=Tomita en-aut-mei=Susumu kn-aut-name=富田享 kn-aut-sei=富田 kn-aut-mei=享 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳神経外科学教室 en-keyword=deafferentation pain kn-keyword=deafferentation pain en-keyword=deafferentation hyperactivity kn-keyword=deafferentation hyperactivity en-keyword=GABA kn-keyword=GABA en-keyword=glycine kn-keyword=glycine en-keyword=descending inhibitory system kn-keyword=descending inhibitory system END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=1-2 article-no= start-page=1 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental study of central nervous system stimulation on pain relief -Effect of cerebral cortical stimulation on neuronal activity of subnucleus caudalis of spinal trigeminal nucleus in cat- kn-title=中枢神経系の電気刺激による除痛機序に関する基礎的研究 ―とくにネコの大脳皮質電気刺激が三叉神経脊髄路核尾側亜核ニューロン活動におよぼす影響について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effect of electrical stimulation of cerebral cortex on neuronal activity in the subnucleus caudalis of the spinal trigeminal nucleus (STNcd) was examined electrophysiologically in the cat. The nociceptive neuronal firing in the STNcd was suppressed by electrical stimulation of contralateral cerebral cortex (primary motor : Msl or primary somatosensory : Sml cortical area.) The high amplitude spontaneous and continuous neuronal hyperactivity (deafferentation hyperactivity : DH), which was provoked in the left STNcd after complete ablation of left Gasserian ganglion, was conspicuously suppressed by the electrical stimulation of the cerebral cortex (Msl stimulation : 5/36 ; Sml stimulation : 12/36). Almost all neurons (nociceptive and DH neuron), the neuronal activity of which was suppressed by electrical stimulation of cerebral cortex, were located in the dorsal and ventral reticular subnuclei of STNcd. On the other hand, the injection of wheat germ agglutinin labeling horseradish peroxidase into the cerebral cortex (Msl) demonstrated that the efferent fibers passed through the internal capsule (IC) and projected directly to the dorsal and ventral reticular subnuclei of the STNcd of the contralateral side. This study suggested that the neuronal firing in STNcd (nociceptive neuronal firing and DH) was suppressed by stimulation of the inhibitory efferent fibers from the cerebral cortex to STNcd by electrical stimulation of IC and cerebral cortex. en-copyright= kn-copyright= en-aut-name=MasaokaTetsuya en-aut-sei=Masaoka en-aut-mei=Tetsuya kn-aut-name=正岡哲也 kn-aut-sei=正岡 kn-aut-mei=哲也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳神経外科学教室 en-keyword=intractale pain kn-keyword=intractale pain en-keyword=deafferentation hyperactivity kn-keyword=deafferentation hyperactivity en-keyword=deafferented pain kn-keyword=deafferented pain en-keyword=cerebral cortex kn-keyword=cerebral cortex en-keyword=internal capsule kn-keyword=internal capsule END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=445 end-page=455 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on pathogenesis of intractable asthma Part 2. Clinical features of late onset intractable asthma kn-title=難治性喘息の発症病態に関する研究 第2編 中高年発症型難治性喘息の臨床像について en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the pathogenesis of late onset intractable asthma (LOIA), 102 asthmatics were classified into early (<40y.o.) and late onset asthma (>40y.o.), or intractable and non-in-tractable asthma. Clinical and allergic examinations were evaluated in each asthma group. Sixty nine percent of the late onset asthmatics had perennial type attacks. IgG-as well as IgE-mediated allergic reactions were suggested by the findings of immediate skin reaction, IgE RIST and RAST score to Candida allergen and reactivity of basophils to anti-immunoglobulin antisera in LOIA. Neutrophils in bronchoalveolar lavage fluid increased significantly in LOIA as compared with the early onset intractable asthma (EOIA) groups (p<0.05). In the pulmonary function test, a striking fall of % V25 was observed in both EOIA ans LOIA. The chest X-ray film frequently revealed microndular shadows in LOIA. Marked morphological changes in the transbronchial lung biopsied specimens were observed in the late onset asthmatics. These findings suggest that a non-IgE reaction, neutrophil infiltration in the local allergic site and histolpgical changes of lung tissue lead to LOIA. en-copyright= kn-copyright= en-aut-name=NakayamaKengo en-aut-sei=Nakayama en-aut-mei=Kengo kn-aut-name=中山堅吾 kn-aut-sei=中山 kn-aut-mei=堅吾 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=late onset kn-keyword=late onset en-keyword=intractable asthma kn-keyword=intractable asthma en-keyword=IgG kn-keyword=IgG en-keyword=neutrophil kn-keyword=neutrophil en-keyword=transbronchoscopic lung biopsy kn-keyword=transbronchoscopic lung biopsy END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=433 end-page=443 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on pathogenesis of intractable asthma Part 1. Characteristices of clinical and immuno-pathological findings in intractable asthma kn-title=難治性喘息の発症病態に関する研究 第1編 難治性喘息の臨床的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the pathogenesis of intractable asthma, clinical features, allergic examinations, pulmonary functions and histological finding were evaluated in 27 intractable asthmatics compared with 33 non-intractable asthmatics. Almost all of the intractable asthmatics had chronic and perennial asthma attacks and also had highly frequent episodes of respiratory infection. IgG-as well as IgE-mediated allergic reactions were proved by the findings of skin reaction, IgE RAST score, precipitating antibody and reactivity of basophils to anti-immunoglobulin antisera in the intractable asthmatics but not in the non-intactable asthmatics. Neutrophils of BALF and peripheral blood increased markedly in the intractable asthmatics as compared with the non-intractable asthmatics. The fall of % V(25) on flow volume curve in the intractable asthmatics, indicated small air way obstruction. Micronodular shadows on the chest X-ray film were frequently seen in the intractable asthmatics. Many histological findings were shown on lung specimens obtained by TBLB in the intrac-table asthmatics. These findings indicate that multiple factors of allergic reaction mediated by IgG, migrated neutrophils and organic changes of lung tissue lead to severe and intractable asthma attack. en-copyright= kn-copyright= en-aut-name=NakayamaKengo en-aut-sei=Nakayama en-aut-mei=Kengo kn-aut-name=中山堅吾 kn-aut-sei=中山 kn-aut-mei=堅吾 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=intractable asthma kn-keyword=intractable asthma en-keyword=Candida kn-keyword=Candida en-keyword=IgG kn-keyword=IgG en-keyword=neutrophil kn-keyword=neutrophil en-keyword=transbronchoscopic lung biopsy kn-keyword=transbronchoscopic lung biopsy END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=341 end-page=354 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Adequate antiplatelet therapy on the basis of individual variation in platelet aggregation in the late period after cardiovascular surgery kn-title=血小板凝集能の個体差を考慮した至適抗血小板療法―心臓血管外科手術後遠隔期における検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Platelet aggregation was studied on 670 samples of 20 healthy controls and 279 patients in the late period after cardiovascular surgery. Aggregating agents used were 0.5 and 2.0μM ADP as well as 2mM arachidonic acid (AA). Among the healthy controls, a maximum aggregation rate over 18% (ADP 0.5μM) was considered hyperaggregability, those under 47% (ADP 2μM) or under 78% (AA 2mM) consid-ered hypoaggregability. Maximun aggregation rate in patients not given antiplatelt agents widely varied from hyperaggregability to hypoaggregability. There was a positive correlation botween the first sample and the second one gained from each patient. This suggested that individual variation existed on platelet aggregation. Maximum aggregation rate significatly decreased by ticlopidine for ADP and by aspirin for AA. Both ADP and AA should be used for platelet aggregation. Comparison among three groups of different ticlopidine doses revealed that the doses should be decided on the basis of platelet aggregation for each patient. Thrombotic or hemorrhagic complications were observed in only 9 cases. Four of 7 cases of thrombotic complicatiion showed hyperaggregability and only 1 case showed hypoaggregability. Both cases of hemorrhagic complication showed hypoaggregability. These findings suggest that indication for antiplatelet therapy and doses of antiplatelet agent should be decided in consideration of individual variation on platelet aggregation. en-copyright= kn-copyright= en-aut-name=TsushimaYoshimasa en-aut-sei=Tsushima en-aut-mei=Yoshimasa kn-aut-name=津島義正 kn-aut-sei=津島 kn-aut-mei=義正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=血小板凝集能 kn-keyword=血小板凝集能 en-keyword=抗血小板薬 kn-keyword=抗血小板薬 en-keyword=ADP kn-keyword=ADP en-keyword=アラキドン酸 kn-keyword=アラキドン酸 en-keyword=術後遠隔期 kn-keyword=術後遠隔期 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=927 end-page=943 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Neuropathological study on neuronal swelling degeneration in the substantia nigra of Olivo-Ponto-Cerebellar Atrophy (OPCA) kn-title=Olivo-Ponto-Cerebellar Atrophy (OPCA) の中脳黒質ニューロンの腫脹性病変について en-subtitle= kn-subtitle= en-abstract= kn-abstract=In 6 out of 7 autopsy cases of olivopontocerebellar atrophy, we found characteristic features of neuronal swelling degeneration (abbr. NSD) in the nerve cell of the substantia nigra. NSD was classified into 4 types according to the microscopic features. The cell body of the type A NSD is much larger than the usual nerve cell, contains melanin granules, is round in shape and appears granular. This cell sometimes contains a shrunken nucleus, Marinesco body, Nissl granules and rest of melanin pigment, suggesting its origin in the degenerating melanin containing nerve cell. In type B NSD the periphery of the swollen cell body appears to be frosted glass with a Nissl Substance. A part of the type B NSD was suggested to have its origin in the nerve cell which has no melanin pigment. Type C NSD is round or irregular in shape and appears to be vacuolar, suggesting its origin in the dendritic process. Type D NSD is sharply bounded from the surrounding tissue and amorphous structures. Judging from its staining characteristics, its origin was suggested to be in the axon. The significance and pathogenesis of the NSD are discussed with special reference to its relation to glutamic acid. en-copyright= kn-copyright= en-aut-name=NambaMasuyuki en-aut-sei=Namba en-aut-mei=Masuyuki kn-aut-name=難波益之 kn-aut-sei=難波 kn-aut-mei=益之 aut-affil-num=1 ORCID= en-aut-name=TanakaTakaho en-aut-sei=Tanaka en-aut-mei=Takaho kn-aut-name=田中隆穂 kn-aut-sei=田中 kn-aut-mei=隆穂 aut-affil-num=2 ORCID= en-aut-name=IshinoHirosi en-aut-sei=Ishino en-aut-mei=Hirosi kn-aut-name=石野博志 kn-aut-sei=石野 kn-aut-mei=博志 aut-affil-num=3 ORCID= en-aut-name=SenoHaruo en-aut-sei=Seno en-aut-mei=Haruo kn-aut-name=妹尾晴夫 kn-aut-sei=妹尾 kn-aut-mei=晴夫 aut-affil-num=4 ORCID= en-aut-name=IshizuHideki en-aut-sei=Ishizu en-aut-mei=Hideki kn-aut-name=石津秀樹 kn-aut-sei=石津 kn-aut-mei=秀樹 aut-affil-num=5 ORCID= en-aut-name=KurodaSigetosi en-aut-sei=Kuroda en-aut-mei=Sigetosi kn-aut-name=黒田重利 kn-aut-sei=黒田 kn-aut-mei=重利 aut-affil-num=6 ORCID= en-aut-name=KuyamaKeisuke en-aut-sei=Kuyama en-aut-mei=Keisuke kn-aut-name=久山圭介 kn-aut-sei=久山 kn-aut-mei=圭介 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=慈圭精神医学研究所 affil-num=2 en-affil= kn-affil=西宇部病院 affil-num=3 en-affil= kn-affil=島根医科大学神経精神医学教室 affil-num=4 en-affil= kn-affil=島根医科大学神経精神医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部神経精神医学教室 en-keyword=OPCA kn-keyword=OPCA en-keyword=Substantia nigra kn-keyword=Substantia nigra en-keyword=neuronal swelling degeneration kn-keyword=neuronal swelling degeneration en-keyword=glutamate kn-keyword=glutamate END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=11-12 article-no= start-page=1145 end-page=1158 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Histopathological study on the lesions of the cerebral cortex and the subcortical white matter in Neuro-Behçet's disease kn-title=Neuro-Behçet 病における大脳皮質,皮質下白質の病変 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Foci of tissue sponginess and necrosis in the cerebral cortex and the subcortical white matter were studied histopathologically in three cases of Neuro-Behçet's disease. The following results were obtained: Lesions in the cerebral cortex and the subcortical white matter were less severe than those in the brain stem. Though recent and older foci coexisted, glial scar foci were rare. Necrotic foci in the cerebral cortex and the subcortical white matter were vascular in origin. Foci were more numerous in the cerebral cortex than in the subcortical white matter. Foci were relatively numerous in the temporal lobe, especially in the hippocampus (Case 2), and were not so numerous in the frontal lobe. Mental symptoms such as hypospontaneity, blunted affect, euphoria, distrubance of immediate and recent memory, forced laughing and crying and bradyphrenia are attributable to brain stem lesions, but some cases of Neuro-Behçet's disease with numerous necrotic foci in the hippocampus and adjacent structures are believed to have hippocampal amnesia superimosed on brain stem symptoms. en-copyright= kn-copyright= en-aut-name=OhbayashiMasakazu en-aut-sei=Ohbayashi en-aut-mei=Masakazu kn-aut-name=大林正和 kn-aut-sei=大林 kn-aut-mei=正和 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=Neuro-Behçet's disease kn-keyword=Neuro-Behçet's disease en-keyword=microspongy state of the cerebral cortex kn-keyword=microspongy state of the cerebral cortex en-keyword=subcortical white matter change kn-keyword=subcortical white matter change END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=11-12 article-no= start-page=1117 end-page=1125 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the role of interferon gamma (IFN-γ) in the pathogenesis of bronchial asthma : Evaluation of IFN-γ production induced by Candida or mite antigen in comparison with other factors of lymphocytic function kn-title=気管支喘息における interferon-γ (IFN-γ) 産生能に関する研究 第2編 気管支喘息における IFN-γ 産生能と各種リンパ球機能との比較検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It is known that IFN-γ, T-cell lymphokine, has potent effects on immunoglobulin synthesis, leukotrienes synthesis and delayed-type hypersensitivity. These factors are thought to be closely related to allergic reactions in bronchial asthma. Therefore, IFN-γ production from peripheral blood mononuclear cells induced by Candida or mite antigen was examined in asthmatics, and relations with other lymphocytic functions were studied to eluciate the role of IFN-γ. The results were as follows : (1) There was a significant correlation between IFN-γ production and Candida specific serum IgG1 antibody. (2) There was a significant correlation between IFN-γ production and lymphocyte blastgenesis induced by Candida antigen. (3) High levels of IFN-γ production were observed in asthmatics with positive late phase or delayed phase skin reaction to Candida antigen compared to asthmatics with negative late phase or delayed phase skin reaction. (4) Asthmatics with positive Candida or mite specific IgE radioallergosorbent test(RAST) showed a low level of IFN-γ production compared to asthmatics with negative IgE RAST. These results indicate that asthmatics with low IgE antibody and activated lymphocytes show high levels of IFN-γ production, and in these low IgE asthmatics, IFN-γ may play an important role in the allergic reactions of bronchial asthma. en-copyright= kn-copyright= en-aut-name=KimuraGoro en-aut-sei=Kimura en-aut-mei=Goro kn-aut-name=木村五郎 kn-aut-sei=木村 kn-aut-mei=五郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=delayed-type hypersensitivity kn-keyword=delayed-type hypersensitivity en-keyword=IFN-γ kn-keyword=IFN-γ en-keyword=IgE antibody kn-keyword=IgE antibody en-keyword=IgG1 antibody kn-keyword=IgG1 antibody END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=9-10 article-no= start-page=923 end-page=929 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Combined resection of lung cancer and invaded aorta with the use of simple temporary bypass : A case reort kn-title=肺癌における簡易式一時バイパス法を用いた大動脈合併切除の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Left pneumonectomy and concomitant resection of the invaded aorta were performed by the simple temporary bypass method. The patient was a 59-year-old male with the chief complaint of left thoracic pain. The 57×43×35 mm tumor was in a region centering on segment 6 of the left lung and had infiltrated the descending aorta. It was diagnosed as T4NOMO, Stage IIIb. A bypass for blood flow was established between the aortic arch avobe the invasion and the left femoral artery, after ligation of the pulmonary artery and vein and closure of the left bronchial stump. Vascular blocking forceps were applied to the descending aorta above and below the tumor infiltration, and two thirds of the circumference of the invaded aortic wall, 4.0×3.0 cm, along with the tumor, was resected. Reconstruction was performed with an 18mm Cooly double velour graft. Blood pressure was monitored with a pressure probe inserted into the right femoral artery. It did not fall below 60 mmHg during the operation. Local recurrence was observed 10 montns post-operatively, and the patient is now receiving radiation therapy. en-copyright= kn-copyright= en-aut-name=InoueFumiyuki en-aut-sei=Inoue en-aut-mei=Fumiyuki kn-aut-name=井上文之 kn-aut-sei=井上 kn-aut-mei=文之 aut-affil-num=1 ORCID= en-aut-name=KamikawaYasuaki en-aut-sei=Kamikawa en-aut-mei=Yasuaki kn-aut-name=上川康明 kn-aut-sei=上川 kn-aut-mei=康明 aut-affil-num=2 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=3 ORCID= en-aut-name=GouchiAkira en-aut-sei=Gouchi en-aut-mei=Akira kn-aut-name=合地明 kn-aut-sei=合地 kn-aut-mei=明 aut-affil-num=4 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=5 ORCID= en-aut-name=HataTakato en-aut-sei=Hata en-aut-mei=Takato kn-aut-name=畑隆登 kn-aut-sei=畑 kn-aut-mei=隆登 aut-affil-num=6 ORCID= en-aut-name=KuinoseMasahiko en-aut-sei=Kuinose en-aut-mei=Masahiko kn-aut-name=杭ノ瀬昌彦 kn-aut-sei=杭ノ瀬 kn-aut-mei=昌彦 aut-affil-num=7 ORCID= en-aut-name=NanbaHirofumi en-aut-sei=Nanba en-aut-mei=Hirofumi kn-aut-name=難波宏文 kn-aut-sei=難波 kn-aut-mei=宏文 aut-affil-num=8 ORCID= en-aut-name=TaniguchiGyou en-aut-sei=Taniguchi en-aut-mei=Gyou kn-aut-name=谷口堯 kn-aut-sei=谷口 kn-aut-mei=堯 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=心臓病センター榊原病院外科 affil-num=7 en-affil= kn-affil=心臓病センター榊原病院外科 affil-num=8 en-affil= kn-affil=心臓病センター榊原病院外科 affil-num=9 en-affil= kn-affil=心臓病センター榊原病院外科 en-keyword=簡易式一時バイパス kn-keyword=簡易式一時バイパス en-keyword=大動脈合併切除 kn-keyword=大動脈合併切除 en-keyword=進行性肺癌 kn-keyword=進行性肺癌 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=853 end-page=861 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the mechanism of initial attack in intractable asthma Part 1. The possible role of various respiratory viruses in bronchial asthma kn-title=難治性喘息の発症に関する研究 第1編 気管支喘息の発症における各種気道感染ウイルスの役割に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Allergen exposure leads to production of the specific IgE antibody and bronchospasm in atopic asthmatics. However, in adult cases with non-atopic asthma, the mechanism of asthma attack is still unknown. We observed that many adult asthmatics had fever and cold symptoms immediately before developing their first attack. Therefore, we measured the serum antibody titers against nine viruses (Influenza A and B, Adenovirus, RSV, Coxsackie B type 3, CMV, Parainfluenza type 1, 2, and 3), and analyzed their relationship with other clinical paremeters to elucidate the possible role of virus infection in inducing asthma attack. (1) No difference in antibody titers was observed between atopic and non-atopic asthmatics. (2) Steroid-dependent asthmatics had a higher antibody against CMV, and lower antibody against Coxsackie virus as compared with non-steroid dependent patients. (3) The anti-CMV antibody showed a significant correlation with the specific IgG antibody and lymphocyte blastogenesis to Candida antigen. (4) To examine the cross reactivity between Candida antigen and CMV, Candida antigen-specific-human monoclonal antibody was used but the result was negative. These findings suggest that the relationship between CMV and Candida is important in the pathogenesis of non-atopic adult asthmatics, although the mechanism is still unknown. en-copyright= kn-copyright= en-aut-name=TakataMinoru en-aut-sei=Takata en-aut-mei=Minoru kn-aut-name=高田穣 kn-aut-sei=高田 kn-aut-mei=穣 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=intractable asthma kn-keyword=intractable asthma en-keyword=viral infection kn-keyword=viral infection en-keyword=Candida antigen kn-keyword=Candida antigen END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=833 end-page=842 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the allergic features of severe bronchial asthma kn-title=気管支喘息の重症化要因に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The allergic responses to mite and Candida antigen were analyzed in atopic and non-atopic asthmatics to clarify the mechanisms of severe bronchial asthma. Skin responses and serum level of antigen specific IgE to mite antigen were lower in severe atopic asthmatics, especially in intractable atopic asthmatics. The serum level of antigen specific IgG1 and responses of peripheral blood lymphocytes to mite antigen showed no difference with severity in either type of asthma. Atopic severe asthmatics had higher serum levels of antigen specific IgE antibodies to Candida antigen and higher serum levels of antigen specific IgG1 antibodies to Candida antigen than atopic mild and moderate asthmatics. Non-atopic severe asthmatics had higher serum levels of antigen specific IgG1 antibodies to Candida antigen and higher responses of peripheral blood lymphocyte to Candida antigen than non-atopic mild and moderate asthmatics. In atopic and non-atopic severe asthmatics, bronchial provocation tests by Candida antigen showed higher positive responses than mild and moderate asthmatics. These findings suggest that a common mechanism makes asthma severe in atopic and non-atopic asthma and that Candida antigen plays an important role in both types of asthma. en-copyright= kn-copyright= en-aut-name=NambaYasuo en-aut-sei=Namba en-aut-mei=Yasuo kn-aut-name=難波康夫 kn-aut-sei=難波 kn-aut-mei=康夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=重症化 kn-keyword=重症化 en-keyword=病型 kn-keyword=病型 en-keyword=カンジダ kn-keyword=カンジダ END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=1 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical significance of Creola body in the sputum of bronchial asthmatics kn-title=気管支喘息における喀痰中の Creola body に関する研究 第1編 気管支喘息患者喀痰中における Creola body の臨床的意義についての検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To examine the clinicopathology of agglomerated bronchial epithelial cells, i. e. Creola body (CrB), in the sputum, the incidence of CrB stained by Papanicoloaou's method was evaluated in 46 bronchial asthmatics and 10 patients with obstructive pulmonary diseases, and then was compared with the pathogenetic factors of bronchial asthma. CrB was observed specifically in the sputum of bronchial asthmatics. CrB-positive cases had asthma attacks for more than 4 days and a high incidence of eosinophils in the sputum, but not CrB-negative cases. The presence of CrB in the sputum tended to be high in non-atopic asthmatics with a low serum IgE level, but had no significant correlation with either the incidence of neutrophils in the sputum, the present age of patients, the severity of the disease or bronchial hyperresponsiveness to acetylcholine. These findines suggest that the involvement of histolesional factors such as persistent bronchial contraction and release of major basic protein from eosinophils in the airway may lead to the formation of CrB. Also the appearance of CrB may be a useful index for pre-serious stage of asthma. en-copyright= kn-copyright= en-aut-name=IsoshimaKoji en-aut-sei=Isoshima en-aut-mei=Koji kn-aut-name=磯嶋浩二 kn-aut-sei=磯嶋 kn-aut-mei=浩二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=sputum kn-keyword=sputum en-keyword=Creola body kn-keyword=Creola body en-keyword=eosinophil kn-keyword=eosinophil en-keyword=neutrophil kn-keyword=neutrophil END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=809 end-page=820 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on IgG subclass antibodies in asthmatics with late asthmatic responses Part 2. Antigen-specific IgG subclass antibodies in the BALF of asthmatics with late asthmatic responses kn-title=遅発型気道反応におけるIgG サブクラス抗体に関する研究 第2編 気管支肺胞洗浄液中抗原特異的 IgG サブクラス抗体と遅発型気道反応の関連について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Immunoglobulin classes which induce a non-immediate asthmatic response (non-IAR) in the case of low level of IgE antibody are still unknown, although IAR is mediated by IgE. To elucidate the relationship between antibodies and late asthmatic responses (LAR), antigen-specific IgG subclass antibodies in the serum and bronchoalveolar lavage fluid (BALF) of asthmatics were measured by avidin-biotin ELISA before provocation by antigen. The BALF levels of IgG and IgG1 antibodies to mite and Candida antigen in bronchial asthmatics were higher than those in healthy subjects (p<0.05). Followed by inhalation of house dust or Candida antigen, bronchial asthmatics were divided into group A (higher levels of BALF IgG1 antibody) and gourp B (lower levels of BALF IgG1 antibody). The percentages of LAR including DAR after inhalation of house dust antigen in group A were significantly higher than those in group B (p<0.05). The percentages of LAR including DAR after inhalation of Candida antigen in group A were significantly higher than those in group B (p<0.01). In asthmatics with LAR after inhalation of house dust antigen or Candida antigen, the BALF levels of antigen-specific IgG and IgG1 antibodies were significantly higher than those in asthmatics without LAR of healthy subjects (p<0.01). In asthmatics with LAR after inhalation of house dust antigen or Candida antigen, the BALF levels of antigen-specific IgG and IgG1 antibodies were significantly higher than those in asthmatics without LAR of healthy subjects (p<0.01). In asthmatics with LAR, the relative (to albumin) of coefficients of excretion (RCE) in the BALF of antigen-specific IgG and IgG1 antibodies were higher than those in asthmatics without LAR of healthy subjects. These findings suggest that local production of antigen-specific IgG and IgG1 antibodies incerases in asthmatics with LAR, and that these antibodies may induce LAR. en-copyright= kn-copyright= en-aut-name=OgurusuKazuro en-aut-sei=Ogurusu en-aut-mei=Kazuro kn-aut-name=小栗栖和郎 kn-aut-sei=小栗栖 kn-aut-mei=和郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=遅発型気道反応 kn-keyword=遅発型気道反応 en-keyword=IgG サブクラス抗体 kn-keyword=IgG サブクラス抗体 en-keyword=気管支肺胞洗浄 kn-keyword=気管支肺胞洗浄 en-keyword=難治性喘息 kn-keyword=難治性喘息 en-keyword=抗原吸入誘発試験 kn-keyword=抗原吸入誘発試験 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=797 end-page=807 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on IgG subclass antibodies in asthmatics with late asthmatic responses Part 1. Serum antigen-specific IgG subclass antibodies in asthmatics with late asthmatic response kn-title=遅発型気道反応におけるIgG サブクラス抗体に関する研究 第1編 血清中抗原特異的 IgG サブクラス抗体と遅発型気道反応の関連について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The immediate asthmatic response is mainly induced by IgE-dependent mechanisms. However, the late asthmatic response (LAR) is induced by inhalation of antigens without the participation of antigen-specific IgE antibodies in some asthmatics, especially in intractable asthma induced by Candida antigen. To elucidate the relationship between antibodies and those bronchial responses, the antigen-specific IgG subclass antibodies in sera from asthmatics were measureed and compared with IgE antibody. The avidin-biotin ELISA (enzyme-linked immunosorbent assay) method was established for the measurement of specific IgG and IgG subclass antibodies to mite or Candida antigen. Serum levels of IgG and IgG1 antibodies to mite and Candida antigen in bronchial asthmatics were significantly higher than those in healthy subjects (p<0.01). Bronchial asthmatics who were tested with inhalation of house dust or Candida antigen were divided into group A (higher levels of serum IgG1 antibody) and group B (lower levels of serum IgG1 antibody). The percentage of LAR including DAR after inhalation of house dust antigen in group A were significantly higher than those in group B (p<0.01). The percentages of LAR and LAR including DAR after inhalation of Candida antigen in group A were significantly higherSerum levels of house du than those in group B(p<0.01). Serum levels of antigen-specific IgG and IgG1 antibodies in asthmatics with LAR after inhalation of house dust or Candida antigen were significantly higher than those in asthmatics with IAR or non-responders (p<0.01). The serum level of specific IgE antibody to these antigens in asthmatics with LAR after inhalation of house dust or Candida antigen was slightly lower than that in the asthmatics without LAR, though the difference was not significant. These findings suggest that high serum levels of specific IgG and IgG1 antibodies to adequate antigens play a role in inducing an attack in asthmatics with LAR. en-copyright= kn-copyright= en-aut-name=OgurusuKazuro en-aut-sei=Ogurusu en-aut-mei=Kazuro kn-aut-name=小栗栖和郎 kn-aut-sei=小栗栖 kn-aut-mei=和郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=遅発型気道反応 kn-keyword=遅発型気道反応 en-keyword=IｇG サブクラス抗体 kn-keyword=IｇG サブクラス抗体 en-keyword=IgE 抗体 kn-keyword=IgE 抗体 en-keyword=抗原吸入誘発試験 kn-keyword=抗原吸入誘発試験 en-keyword=難治性喘息 kn-keyword=難治性喘息 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=791 end-page=801 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the regulation of eosinophils in bronchial asthma Part 2. Migratory responses of eosinophils from asthmatics kn-title=気管支喘息における好酸球動態の調節に関する研究 第2編 喘息患者末梢血好酸球の遊走能に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Eosinophil infiltration in lung tissue is one of the characteristic features of bronchial asthma. Such cell infiltration seems to be induced by the eosinophil chemotactic factor (ECF). PAF and IL-5 are potent chemoattractants and activators for eosinophils. To evaluate the reactivity of eosinophils in asthmatics under various conditions, the migratory function of eosinophils to PAF and IL-5 was investigated by the modified Boyden chamber method. Eosinophils of asthmatics were highly purified using a flow cytometric method previously reported. The migratory response of the eosinophils of asthmatics was greater than that of healthy suljects. Eosinophils from atopic asthmatics showed a higher response to PAF than those from non-atopic asthmatics. Eosinophils in the attack stage showed a higher response than those in the non-attack stage. Hypodense eosinophils showed an increased migratory response. The migratory response was correlated to the serum concentration of ECP and blood eosinophil count. These findings suggest that the reactivity of eosinophils is heterogenous and relates to the degree of eosinophilia, and that IL-5 as well as PAF plays an important role in the pathogenesis of bronchial asthma. en-copyright= kn-copyright= en-aut-name=TakahashiHisaho en-aut-sei=Takahashi en-aut-mei=Hisaho kn-aut-name=高橋寿保 kn-aut-sei=高橋 kn-aut-mei=寿保 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Bronchial asthma kn-keyword=Bronchial asthma en-keyword=Eosinophil migratory response kn-keyword=Eosinophil migratory response en-keyword=Platelet-activating factor kn-keyword=Platelet-activating factor en-keyword=Interleukin-5 kn-keyword=Interleukin-5 en-keyword=Eosinophil heterogeneity kn-keyword=Eosinophil heterogeneity END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=777 end-page=787 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the role of neutrophils in intractable asthma Part 2. Leukotriene production of neutrophils by immunological stimulation kn-title=難治性喘息における好中球の役割に関する研究 第2編 好中球からの免疫学的刺激による Leukotrienes 産生能に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Previously, I reported that more leukotrienes (LTs) and superoxides were produced from the neutrophil-rich fraction by non-immunological stimulation with CaI in intractable asthmatics than in non-intractable asthmatics. This suggested that neutrophils are involved in the pathogenesis of intractable asthma. To investigate the process of neutrophil activation in intractable asthma, the LTs production from neutrophils by immunological stimulation was measured by high performance liquid chromatography (HPLC). LTs were produced from neutrophils by stimulation of anti-IgG and zymosan activated serum (ZAS), but not anti-IgE. However, there was no significant difference with each disease severity of asthma. The production from neutrophils was also detected by Candida antigen stimulation. Moreover, the production of LTC4 from neutrophils by this stimulation was higher in intractable asthmatics than in non-intractable asthmatics. These findings suggested that neutrophils are produced LTs by immunological stimulation such as by Candida antigen based on the IgG mediated allergy reaction, and play an important role in the pathogenesis of intractable asthma. en-copyright= kn-copyright= en-aut-name=ShimizuIkki en-aut-sei=Shimizu en-aut-mei=Ikki kn-aut-name=清水一紀 kn-aut-sei=清水 kn-aut-mei=一紀 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=難治性喘息 kn-keyword=難治性喘息 en-keyword=好中球 kn-keyword=好中球 en-keyword=好酸球 kn-keyword=好酸球 en-keyword=ロイコトリエン kn-keyword=ロイコトリエン END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=779 end-page=789 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the regulation of eosinophils in bronchial asthma Part 1. Characterization of eosinophil chemotactic factor (ECF) derived from peripheral blood mononuclear cells stimulated with Candida antigen kn-title=気管支喘息における好酸球動態の調節に関する研究 第1編 喘息患者末梢血単核球由来の好酸球遊走因子（ECF）の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Eosinophilic infiltration in bronchial tissue is characteristic in the pathogenesis of bronchial asthma. The eosinophil chemotactic factor (ECF) derived from mononuclear cells has been reported to have some effect on the cell infiltration, and interleukin-5 (IL-5), a lymphokine derived from T lymphocytes, to be a factor related to growth, chemotaxis and activation for eosinophils. Lymphocytes accumulated in the bronchoalveolar lavage fluids of non-atopic and severe asthmatics have been shown to be highly responsive to Candida antigen, and high ECF production was observed in non-atopic and severe asthmatics by measurement of ECF activity in the supernatant of peripheral blood mononuclear cells cultured with Candida antigen. In this report, the molecular weight by gel filtration and inhibition test using anti-murine IL-5 antibody were studied to characterize the lymphocyte-derived ECF. Gel filtration analysis of the ECF indicated a molecular weight of 20,000 to 65,000 Da with a peak of activity around 40,000 to 50,000 Da. The ECF activity was reduced by incubation with anti-murine IL-5 antibody, which suggests that the supernatant contains IL-5. ECF from mononuclear cells, containing IL-5, may play an important role in the pathogenesis of eosinophil infiltration in non-atopic and severe asthmatics. en-copyright= kn-copyright= en-aut-name=TakahashiHisaho en-aut-sei=Takahashi en-aut-mei=Hisaho kn-aut-name=高橋寿保 kn-aut-sei=高橋 kn-aut-mei=寿保 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Bronchial asthma kn-keyword=Bronchial asthma en-keyword=Candida antigen Eosinophil chemotactic factor kn-keyword=Candida antigen Eosinophil chemotactic factor en-keyword=Interleukin-5 kn-keyword=Interleukin-5 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=735 end-page=746 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the mechanism and treatment of intractable asthma Part 2. The mechanism of specific thromboxane A(2) synthetase inhibitor in cell-mediated allergy in intractable asthmatics kn-title=難治性喘息の病態と治療に関する研究 第2編 難治性喘息における細胞反応型アレルギーに対する選択的 Thromboxane A(2) 合成酵素阻害剤の抑制機序について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The specific thromboxane A(2) (TXA(2)) synthetase inhibitor (OKY-046) seems to be a useful drug in the treatment of intractable asthmatics. In this study, to clarify the action mechanism of OKY-046 and the relationship between TXA(2) and prostaglandin E(2) (PGE(2)) in cell-mediated allergy, the effect of the TXA(2) receptor antagonist (AA-2414), TXA2 analogue (STA(2)) and PGE(2) for peripheral blood mononuclear cells in adult intractable asthmatics was studied. OKY-046 significantly suppressed TXB(2) production and increased PGE(2) production from the peripheral blood mononuclear cells stimulated by PHA and Candida antigen, but AA-2414 had no effect. AA-2414 suppressed lymphocyte blastgenesis, but did not suppress significantly interleukin-2 (IL-2) or neutrophil chemotactic factor (NCF) production. Furthermore, STA(2) increased lymphocyte blastgenesis stimulated by Candida antigen partially, but not dose-dependently. On the other hand, PGE(2) suppressed significantly lymphocyte blastgenesis and IL-2 and NCF production in a dose-dependent manner. These findings suggest that the action mechanism of OKY-046 is a suppressive effect of cell-mediated allergy, and that TXA(2) and PGE(2) play an important role in the mechanism of intractable asthma. en-copyright= kn-copyright= en-aut-name=KanehiroArihiko en-aut-sei=Kanehiro en-aut-mei=Arihiko kn-aut-name=金廣有彦 kn-aut-sei=金廣 kn-aut-mei=有彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Intractable asthma kn-keyword=Intractable asthma en-keyword=thromboxane A(2) kn-keyword=thromboxane A(2) en-keyword=prostaglandin E(2) kn-keyword=prostaglandin E(2) en-keyword=thromboxane A(2) synthetase inhibitor (OKY-046) kn-keyword=thromboxane A(2) synthetase inhibitor (OKY-046) en-keyword=thromboxane A(2) receptor antagonist (AA-2414) kn-keyword=thromboxane A(2) receptor antagonist (AA-2414) END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=721 end-page=733 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the mechanism and treatment of intractable asthma Part 1. Effects of a specific thromboxane A(2) synthetase inhibitor in lymphocyte and neutrophil functions in intractable asthmatics kn-title=難治性喘息の病態と治療に関する研究 第1編 難治性喘息患者のリンパ球および好中球機能に及ぼす選択的 Thromboxane A(2) 合成酵素阻害剤の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify whether thromboxane A(2) (TXA(2)) is involved in type III and IV allergy, so-called "cell-mediated allergy", the effects of a specific TXA(2) synthetase inhibitor, sodium ozagrel (OKY-046) on peripheral blood mononuclear cells and neutrophils in adult intractable asthmatics were studied. Lymphocyte blastogenesis and interleukin-2 (IL-2) production from peripheral blood mononuclear cells stimulated by PHA and Candida antigen in intractable asthmatics was significantly suppressed dose-dependently by OKY-046. The neutrophil chemotactic factor (NCF) and eosinophil chemotactic factor (ECF) from peripheral blood nomonuclear cells stimulated by Candida antigen in intractable asthmatics tended to be suppressed by OKY-046. Furthermore, leukotriene C(4) (LTC(4)) and superoxide (O(2)(-)) production from peripheral blood neutrophils in intractable asthmatics was significantly suppressed dose-dependently by OKY-046. These findings suggest that TXA(2) plays an important role in the development of intractable asthma and OKY-046, which has a suppressive effect on type IV allergy caused by lymphocyte activation and on mediator release from neutrophils, might be a useful drug in the treatment of intractalbe asthmatics. en-copyright= kn-copyright= en-aut-name=KanehiroArihiko en-aut-sei=Kanehiro en-aut-mei=Arihiko kn-aut-name=金廣有彦 kn-aut-sei=金廣 kn-aut-mei=有彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Intractable asthma kn-keyword=Intractable asthma en-keyword=cell-mediated allergy kn-keyword=cell-mediated allergy en-keyword=thromboxane A(2) kn-keyword=thromboxane A(2) en-keyword=thromboxane A(2) synthetase inhibitor (OKY-046) kn-keyword=thromboxane A(2) synthetase inhibitor (OKY-046) END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=619 end-page=628 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Stusies on the pathogenesis in diffuse panbronchiolitis Part 2. Immune responses in diffuse panbronchiolitis kn-title=びまん性汎細気管支炎の病態に関する研究 第2編 びまん性汎細気管支炎患者の免疫能 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Various immunological processes are suspected of having some relationship with the onset of diffuse panbronchiolitis (DPB). Therefore, the cellular and humoral immunity of patients with DPB were studied. Sera of patients with DPB showed a high frequency of positive RA factor and high titer of cold agglutinin. Delayed skin tests with phytohemagglutinin (PHA) and purified protein derivative (PPD) in patients with DPB revealed normal responses to PHA as nonspecific mitogen and suppressed responses to PPD as specific antigen, although lymphocyte blastogenesis in vitro showed suppressed responses to PHA. The proportion of lymphocytes in bronchoalveolar lavage (BAL) fluid of DPB patients equaled that of normal controls. Furthermore, the CD4/CD8 ratio of T-cell subsets in BAL fluid of DPB patients were significantly lower than that of normal controls, although the CD4/CD8 ratio in peripheral blood of DPB were significantly higher than that in normal controls. The percentage of B-cells in the peripheral blood of DPB patients was hihger than that in normal controls. These data suggest that the activation of cellular and humoral immune mechanisms could play an important role in the pathogenesis of DPB. en-copyright= kn-copyright= en-aut-name=ShiraishiTakamasa en-aut-sei=Shiraishi en-aut-mei=Takamasa kn-aut-name=白石高昌 kn-aut-sei=白石 kn-aut-mei=高昌 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=びまん性汎細気管支炎 kn-keyword=びまん性汎細気管支炎 en-keyword=気管支肺胞洗浄 kn-keyword=気管支肺胞洗浄 en-keyword=リンパ球サブセット kn-keyword=リンパ球サブセット en-keyword=皮内反応 kn-keyword=皮内反応 en-keyword=リンパ球幼若化反応 kn-keyword=リンパ球幼若化反応 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=611 end-page=618 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Stusies on the pathogenesis in diffuse panbronchiolitis Part 1. Cellular components in bronchoalveolar lavage fluid of diffuse panbronchiolitis kn-title=びまん性汎細気管支炎の病態に関する研究 第1編 びまん性汎細気管支炎患者の気道細胞反応 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Diffuse panbronchiolitis (DPB) is known as a chronic progressive inflammation of the peripheral airway followed by lethal respiratory failure. Bronchoalveolar lavage (BAL) was performed to clarify the pathogenesis of DPB compared to chronic bronchitis. The recovery rate of BAL fluid in DPB decreased, but total cell count increased enormously. Furthermore, increased proportions of neutrophils in BAL fluid from DPB patients was characteristic and included a relative decrease in alveolar macrophages. Patients with DPB were classified based on the presence or absence chronic airway infection with Pseudomonas aeruginosa. There was no significant difference in cellular components of BAL fluid among the patients with or without Pseudomonas infection. Patients with DPB showed both obstructive and restrictive ventilatory disturbances. There was no correlation between parameters of these respiratory functions and total cell counts or various cellular proportions in BAL fluid. Infiltrating cell density around bronchioles of patients with DBP was measured. Significantly higher cell density was shown in patinets with DPB compared to other disease controls. There were also significant negative correlations between cell density and respiratory parameters such as % vital capacity, % V50 and % V25. These results indicate that remarkable increase in neutrophils in BAL fluid and the marked cell infiltration around bronchioles in DPB patients could play a crucial role in the pathogenesis of DPB. en-copyright= kn-copyright= en-aut-name=ShiraishiTakamasa en-aut-sei=Shiraishi en-aut-mei=Takamasa kn-aut-name=白石高昌 kn-aut-sei=白石 kn-aut-mei=高昌 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=びまん性汎細気管支炎 kn-keyword=びまん性汎細気管支炎 en-keyword=慢性気管支炎 kn-keyword=慢性気管支炎 en-keyword=気管支肺胞洗浄 kn-keyword=気管支肺胞洗浄 en-keyword=緑膿菌 kn-keyword=緑膿菌 en-keyword=細気管支領域細胞密度 kn-keyword=細気管支領域細胞密度 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=561 end-page=571 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on inhalation provocatopn test of Candida antigen in bronchial asthma kn-title=気管支喘息におけるカンジダ抗原吸入誘発試験の臨床的検討―遅延型気道反応を中心に― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Various allergic mechanisma participate in the reversible bronchospasms of an asthma attack. Candida albicans was suspected as the causative antigen in late-onset and severe intractable asthma. In this study, inhalation provocation test was performed with Candida antigen to evaluate the asthmatic responses of asthmatic patients with positive skin reaction to Candida antigen. More than 20% decrease in park flow after antigen inhalation was considered an asthmatic response and such responses were classified as immediate (IAR), late (LAR) or delayed (DeAR) depending on the time course after antigen inhalation. Provocation tests induced asthmatic responses in 26(42.6%) patients and 11(42.3%) showed DeAR. Eight of the 11 patients with DeARs had late onst asthma and 7 patients had intractable asthma. Furthermore, patients with DeARs showed higher lymphocyte responses to Candida antigen than those with IAR or LAR. These date indicate that EeAR to Canidia antigen plays an important role in the pathogenesis of severe intractable asthma. en-copyright= kn-copyright= en-aut-name=InokiAtsuhiro en-aut-sei=Inoki en-aut-mei=Atsuhiro kn-aut-name=猪木篤弘 kn-aut-sei=猪木 kn-aut-mei=篤弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=難治性喘息 kn-keyword=難治性喘息 en-keyword=カンジダ抗原 kn-keyword=カンジダ抗原 en-keyword=吸入誘発試験 kn-keyword=吸入誘発試験 en-keyword=遅延型気道反応 kn-keyword=遅延型気道反応 en-keyword=リンパ球幼若化反応 kn-keyword=リンパ球幼若化反応 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=539 end-page=547 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Mechanism of immunotherapy related to the production of antigen specific IgG subclass antibodies and leukotrienes in bronchial asthmatics kn-title=気管支喘息患者における減感作療法に作用機序に関する研究―抗原特異的IgGサブクラス抗体とロイコトリエン産生能に及ぼす影響について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the mechanism of immunotherapy in bronchial asthma, the level of mite specific IgG subclass asntibodies (total IgG, IgG(1), IgG(4)) and the production of leukotrienes (LTB(4), LTC(4)) released from leukocytes were examined. Eighteen mite-sensitive asthmatic patiens who received immunotherapy with house dust extract for 1 year were dividel into two groups, the responsive patients and non-responsive patients. Before treatment and 1 year after treatment, the levels of mite specific serum IgG subclass antibodies were measured by enzyme-linked immunosorbent assay (ELISA) and the levels of LTs were measured by high performance liquid chromatography (HPLC). In the responsive group, the level of mite specific serum IgG(4) antibody was significantly increased (p<0.05), and the level of mite specific serum total IgG and IgG(1) antibody was decreased. The release of LTB(4) and LTC(4) from leukocytes stimulated by mite antigen was significantly decreased (p<0.05,p<0.05). These results indicate that increases in the antigen specific IgG(4) and the inhibiton of chemical madiators play important roles in the mechanism of immunotherapy. en-copyright= kn-copyright= en-aut-name=KatagiSachie en-aut-sei=Katagi en-aut-mei=Sachie kn-aut-name=片木幸恵 kn-aut-sei=片木 kn-aut-mei=幸恵 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=immunotherapy kn-keyword=immunotherapy en-keyword=IgG subclass antibodies kn-keyword=IgG subclass antibodies en-keyword=leukotrienes kn-keyword=leukotrienes END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=527 end-page=537 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the cause of intractable asthma using animal model Part 2. Immunoglobulin G, chemical mediators and cell reactions in BALF and peripheral blood of chronic asthma model kn-title=慢性喘息モデルによる喘息の難治化要因に関する研究 第2編 肺局所や血液中における出現細胞及び液性反応に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the mechanism of intractable asthma, we examined the cellular content and chemical mediators in BALF and peripheral blood of a chronic asthma model which we had already established by inhalation of ascaris suum antigen. The serum levels of antigen specific IgG antibody on the eighth day were signicantly higher than those before inhalation. The serum levels of antigen specific IgG(1) antibody increased on the eighth day compared with levels before inhalation. The serum levels of antigen specific IgG(2) antibody as a blocking antibody increased and immediat asthmatic response (IAR) gradually improved until the fourth day. The number of eosinophils after eight days of inhalation was decrease in peripheral blood but was significantly increased in BAL and lung tissue. The serum levels of LTC(4) after eight days of inhalation decreased significanlty compared to those after one day of inhalation. LTB4 concentration in BAL after eight days of inhalation were significanlty lower than those after one day of inhalation. Histamine concentrations were increased in BAL in both the IAR and dual asthmatic response (DAR) animal model. These data suggest that intractable asthma was induced by many kinds of chemical mediators produced by inflammatory cells including eosinophils, mast cell-basophils, neutrophils and lymphocytes. en-copyright= kn-copyright= en-aut-name=SuganoHisashi en-aut-sei=Sugano en-aut-mei=Hisashi kn-aut-name=菅野尚 kn-aut-sei=菅野 kn-aut-mei=尚 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=chronic asthma kn-keyword=chronic asthma en-keyword=guinea pig kn-keyword=guinea pig en-keyword=IgG subclass antibodies kn-keyword=IgG subclass antibodies en-keyword=leukotrienes kn-keyword=leukotrienes en-keyword=histamine kn-keyword=histamine END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=517 end-page=525 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the cause of intractable asthma using animal model Part 1. Establishment of a chronic asthma model by repeated antigen inhalation kn-title=慢性喘息モデルによる喘息の難治化要因に関する研究 第1編 抗原の繰り返し吸入による慢性喘息モデルの作製 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To elucidate the cause of intractable asthma, guinea pigs were actively sensitized by intraperitoneal injection of ascaris suum as an antigen. We repeated the inhalation of aerosolized ascaris antigen eight times in the animal models which consisted of a non-treated group, a metopirone-treated group and a steroid-treated group. We investigated the course of asthmatic response by evaluating the ratio of expirations to inspirations after the inhalation challenge. The frequency of late asthmatic response (LAR) was increased by repeated inhalation of the antigen. There was no significant differnce in the frequency between non-treated group and steroid-treated group, but the metopirone-treated group showed strong LAR compared with the other two groups. The intensity of LAR was gradually increased and that of immediate asthmatic response (LAR) was decreased in the metopirone-treated group. Finally, we established a chronic asthma model in which LAR was strong and the asthma attack was prolonged over twenty-four hours. These results suggest that the model will be useful in clarifying the causes of intractable asthma in humans. en-copyright= kn-copyright= en-aut-name=SuganoHisashi en-aut-sei=Sugano en-aut-mei=Hisashi kn-aut-name=菅野尚 kn-aut-sei=菅野 kn-aut-mei=尚 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=chronic asthma kn-keyword=chronic asthma en-keyword=animal model kn-keyword=animal model en-keyword=guinea pig kn-keyword=guinea pig en-keyword=re-inhalation kn-keyword=re-inhalation en-keyword=late asthmatic response kn-keyword=late asthmatic response END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=505 end-page=516 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on malignant lymphoma Part 2. Natural killer activity in patients with malignant lymphoma kn-title=悪性リンパ腫の病態と治療に関する研究 第2編 悪性リンパ腫における natural killer 活性の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The natural killer (NK) activity of peripheral blood mononuclear cells (PBMC) from patients with malignant lymphoma was examined. In 54 untreated patients, the mean NK activity did not differ significantly from that in healthy controls. However, 17 (31%) of 54 patients showed low NK activity. NK activity did not correlate with the stage, histologic type or patient age. Significant reduction of NK activity was observed during combination chemo-therapy. The mean NK activity in complete respondors (CRs) did not differ significantly from that in healthy controls. However, 5 (14%) of 37 patients who were disease-free for more than 3 years showed low NK activity. Low NK activity was frequently observed in long-term CRs with non-Hodgkin's lymphoma compared with negative PPD skin test, negative PHA skin test, low CD4/CD8 ratio and decreased response of PBMC to PHA and/or Con A. These results indicate that patients with malignant lymphoma have decreased immunity even while in long-term continuous remission and that measuring NK activity is useful for evaluating their immunologic status. en-copyright= kn-copyright= en-aut-name=TagawaShinya en-aut-sei=Tagawa en-aut-mei=Shinya kn-aut-name=田川真也 kn-aut-sei=田川 kn-aut-mei=真也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=lymphoma kn-keyword=lymphoma en-keyword=natural killer activity kn-keyword=natural killer activity en-keyword=immunity kn-keyword=immunity en-keyword=complete respondor kn-keyword=complete respondor en-keyword=chemotherapy kn-keyword=chemotherapy END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=493 end-page=503 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on malignant lymphoma Part 1. Second malignant neoplasms in patients with malignant lymphoma after chemotherapy kn-title=悪性リンパ腫の病態と治療に関する研究 第1編 悪性リンパ腫化学療法後の2次癌発症についての検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The risk of a second malignancy was analyzed in 23 patients with Hodgkin's disease (HD) and 177 with non-Hodgkin's lymphoma (NHL) who were initially treated with combination chemotherapy between 1976 and 1990. Among these patients, 3 cases of gastric cancer, 2 cases of lung cancer, 2 cases of hepatoma, one case of colon cnacer, one case of cholangiocarcinoma and one case of acute myeloblastic leukemia were subsequently observed. Median age at diagnosis of lymphoma was 64 years in patients who developed subsequent malignancies but was 9 years higher than that for the entire lymphoma group. Median interval from srart of chemotherapy to the appearance of second malignancy was 43.9 years and ranged from 1.9 years to 8.8 years. The 7-year cumulative risk of second malignancy in HD and NHL were 7.7% and 11.7%, respectively. In Hodgkin's disease, the incidence of stomach and lung cancers was significantly greater than expected incidence calculated on the basis of age-adjusted person-years. In non-Hodgkin's lymphoma, the incidence was also greater than expected for all malignancies except stomach cancer. This indicater that the incidence of solid malignancy as well as leukemia is higher in lymphoma patients after chemotherapy than in the general population. en-copyright= kn-copyright= en-aut-name=TagawaShinya en-aut-sei=Tagawa en-aut-mei=Shinya kn-aut-name=田川真也 kn-aut-sei=田川 kn-aut-mei=真也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=malignant lymphoma kn-keyword=malignant lymphoma en-keyword=chemotherapy kn-keyword=chemotherapy en-keyword=second primary malignancy kn-keyword=second primary malignancy END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=455 end-page=464 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On localization of inhaled antigens in late asthmatic response in an animal model kn-title=遅発型気道反応の発現機序に関する基礎的研究―吸入抗原の局在について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the initiation of late asthmatic response (LAR), the localization and fate of inhaled antigens were studied using an animal model of LAR. Guinea pigs were sensitized by ascaris suum and aluminum gel. Radioiodinated ascaris suum and ovalbumin as control were subsequently injected into the trachea of the guinea pig to determine the radioactivity of bronchoalveolar lavege (BAL) cells and fluid (BALF) components before and after LAR. The localization of antigens was also examined by autoradiography of BAL cells and lung tissue sections. The radioactivity of radioiodinated ascaris in BAL cells and lung tissue increased during LAR with increases in macrophages and neutrophils, although in non-responding animals inhaled antigens gradualy disappeared from the airway. The radioactivity of radioiodinated ovalbumin gradually decreased regardless of LAR. Autoradiographic study showed that the inhaled antigens were located in the cytoplasm of alveolar macrophages in BALF and lung tissue. These data indicate that inhaled antigens may accumulate and migrate with numerous inflammatory cells such as macrophages and neutrophils in late phase bronchial response. en-copyright= kn-copyright= en-aut-name=TakedaKatsuyuki en-aut-sei=Takeda en-aut-mei=Katsuyuki kn-aut-name=武田勝行 kn-aut-sei=武田 kn-aut-mei=勝行 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=alveolar macrophage kn-keyword=alveolar macrophage en-keyword=guinea pig kn-keyword=guinea pig en-keyword=(125)I-ascaris kn-keyword=(125)I-ascaris en-keyword=late asthmatic response (LAR) kn-keyword=late asthmatic response (LAR) en-keyword=localization of inhaled antigen kn-keyword=localization of inhaled antigen END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=415 end-page=428 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of the dynamic states of pulmonary ventilation and perfusion in bronchial asthmatics using (133)Xe gas ventilation scintigraphy and (99m)Tc-MAA lung perfusion scintigraphy kn-title=気管支喘息における換気血流動態の研究―(133)Xe換気シンチ及び(99m)Tc-MAA血流シンチによる検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the organic changes and pathophysiology of the lungs in intractable asthmatics, the dynamic states of pulmonary ventilation and perfusion were analyzed in 15 bronchial asthmatic in the stable state using (133)Xe gas ventilation scintigraphy and (99m)Tc-MAA lung perfusion scintigraphy, respectively. Dysfunction of pulmonary ventilation and impairment of pulmonary perfusin were significantly severer in intractable asthmatics than in non-intractable asthmatics (p<0.01, P<0.05, respectively) and those of asthma caused by aging. Late onset asthmatics with a long duration of disease tended to show severe impairment of pulmonary perfusion. Above all the longer the duration of the disease the severer became the impairment of pulmonary perfusion in late onset intractable asthmatics (LOIA). These findings suggest that the progression of irreversible organic changes of lungs in LOIA is involved in the severity of brochial asthma. en-copyright= kn-copyright= en-aut-name=IshihamaHidenobu en-aut-sei=Ishihama en-aut-mei=Hidenobu kn-aut-name=石濱英暢 kn-aut-sei=石濱 kn-aut-mei=英暢 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=中高年発症型難治性喘息 (LOIA) kn-keyword=中高年発症型難治性喘息 (LOIA) en-keyword=換気シンチ kn-keyword=換気シンチ en-keyword=血流シンチ kn-keyword=血流シンチ END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=315 end-page=323 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the treatment of intractable asthman Part 2. Effect of Saiboku-to on lymphocyte function in the experimental asthma using guinea pigs kn-title=難治性喘息の治療に関する研究 第2編 モルモット喘息モデルにおけるリンパ球機能に対する柴朴湯の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Saiboku-to is a useful drug in the treatment of intractable asthmatics. The most important action mechanism of Saiboku-to seems to be a suppression on lymphocyte activation. The relationship between the in vitro and in vivo effects is not clear because the metabolism of Kampo medicine is unknown. Therefore, in this study two in vitro experimental systems were compared to evaluate the pharmacological effect of Saiboku-to on the lymphocyte blas-togenesis. The first system involved the addition of serum obtained from guinea pigs treated orally with Saiboku-to, while the second system involved the direct additon of the Saiboku-to extract to the medium. Saiboku-to has a suppressive effect on lymphocyte blastogenesis and also the metabolite of Saiboku-to had a suppressive effect. According to the formula based on these data, the serum level of Saiboku-to on oral administration of the common dose was assumed to be 5.65μg/ml in bronchial asthmatics. These findings suggest that Saiboku-to may an inhibitory effect in the cell-mediated allergic reaction by lymohocyte activation in vivo. en-copyright= kn-copyright= en-aut-name=OkamotoShoichi en-aut-sei=Okamoto en-aut-mei=Shoichi kn-aut-name=岡本章一 kn-aut-sei=岡本 kn-aut-mei=章一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Saiboku-to kn-keyword=Saiboku-to en-keyword=serum level kn-keyword=serum level en-keyword=actively sesitzed model kn-keyword=actively sesitzed model en-keyword=lymphocyte kn-keyword=lymphocyte END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=305 end-page=314 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the treatment of intractable asthman Part 1. Effect of Saiboku-to on cell-mediated allergy in the experimental asthma using guinea pigs kn-title=難治性喘息の治療に関する研究 第1編 モルモット喘息モデルにおける細胞反応型アルルギーに対する柴朴湯の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Saiboku-to seems to be a useful drug in the teatment of intractable asthmatics. The pharmacological effect of Saiboku-to was examined in an experimental model of bronchial asthma with cell-mediated allergy in guinea pigs. The fundings revealed that Saiboku-to inhibited the late asthmatic response. It suppressed the lymphocyte blastogensis by ascaris antigen and eosinophil infiltration into BALF and peribronchial tissue. Moreover, Saiboku-to lowered the levls of LTB4 and LTC4 in the cardiac blood, but not the antigen-specific IgG subclass. These findings suggest that the inhibitory effect of Saiboku-to on the late asthmatic response is caused by the suppression of cell-mediated allergy. en-copyright= kn-copyright= en-aut-name=OkamotoShoichi en-aut-sei=Okamoto en-aut-mei=Shoichi kn-aut-name=岡本章一 kn-aut-sei=岡本 kn-aut-mei=章一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Saiboku-to kn-keyword=Saiboku-to en-keyword=cell-mediated allergy kn-keyword=cell-mediated allergy en-keyword=actively sensitized model kn-keyword=actively sensitized model en-keyword=lymphocyte kn-keyword=lymphocyte en-keyword=leukotrienes kn-keyword=leukotrienes END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=195 end-page=204 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the mechanism of late asthmatic response using a technique of bronchoalveolar lavage Part 2. Bronchial reaction after inhalation of Candida allergen in bronchial asthmatics kn-title=気管支喘息における遅発型気道反応の機序に関する研究 第2編 Candida 抗原による遅発型気道反応局所の細胞反応及びロイコトリエンの変動 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the mechanism of late asthmatic response (LAR) which is related to intractable asthmatic attacks, cellular and humoral components at the sites of LAR were examined by bronchoalveolar lavage fluid (BALF) obtained after bronchial inhalation of Candida allergen. BAL examination was performed 2 hours after the LAR attack. The differential cell count was obtained and the level of leukotrienes (LTs) in the BALF and peripheral blood determined by high performance liquid chromatography. The percentages of eosinophils and basophil・mast cells and neutrophils were statistically high in the BALF after LAR compared with the level in the non-attack state (p<0.05 p<0.01). The level of LTC(4) was significantly higher in the BALF after LAR (p<0.01), and LTB(4) also showed a similar tendency at LAR. However, LTD(4) could not be detected in the BALF after LAR or in the non-attack stage. On the other hands, the percentage of neutorphils and LTB4 level in circulating blood showed a peak before LAR, and then decreased markedly during LAR. Eosinophils also decreased significantly during LAR, but the plasma LTC(4) level increased significantly during LAR. These findings suggest that neutrophils, eosinophils and basophil・mast cells play an important role in the pathogensis of intractable asthma attack and LAR following release of leukotrienes. en-copyright= kn-copyright= en-aut-name=NambaKunihiro en-aut-sei=Namba en-aut-mei=Kunihiro kn-aut-name=難波一弘 kn-aut-sei=難波 kn-aut-mei=一弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Candida antigen kn-keyword=Candida antigen en-keyword=bronchoalveolar lavage kn-keyword=bronchoalveolar lavage en-keyword=inflammatory cell kn-keyword=inflammatory cell en-keyword=late asthmatic response kn-keyword=late asthmatic response en-keyword=leukotrienes kn-keyword=leukotrienes END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=185 end-page=193 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the mechanism of late asthmatic response using a technique of bronchoalveolar lavage Part 1. Bronchial reaction after inhalation of house dust mite allergen in bronchial asthmatics kn-title=気管支喘息における遅発型気道反応の機序に関する研究 第1編 House dust 抗原による遅発型気道反応局所の細胞反応及びロイコトリエンの変動 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To investigate the mechanism of the late asthmatic response (LAR) which participates in intractable asthmatic attacks, humoral and cellular components at the sites of LAR were examined by bronchoalveolar lavage fluid (BALF) obtained after bronchial inhalation of house dust allergen. BAL examination was performed 2 hours after improvement of LAR, and leukotrienes (LTs) measured by high performance liquid chromatography. The level of LTC4 was significantly higher in BALF after LAR(p<0.05), and that of LTB4 was also high at LAR. The increase in the percentage of neutrophils, eosinophils and basophils were evident in BALF after LAR compared with the level in non-attack state and after IAR. However, little LTD4 was detected in the BALF after LAR. On the other hand, the percentage of neutrophils and the LTB4 level in peripheral blood showed a peak at 3 hours after bronchial inhalation of house dust allergen, and then decreased markedly during LAR. These findings suggest that neutrophils, eosinophils, and basophils may release leukotriene-dominant chemical mediators which provoke an asthmatic attack in the late phase response. en-copyright= kn-copyright= en-aut-name=NambaKunihiro en-aut-sei=Namba en-aut-mei=Kunihiro kn-aut-name=難波一弘 kn-aut-sei=難波 kn-aut-mei=一弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=House dust antigen kn-keyword=House dust antigen en-keyword=bronchoalveolar lavage kn-keyword=bronchoalveolar lavage en-keyword=inflammatory cell kn-keyword=inflammatory cell en-keyword=late asthmatic response kn-keyword=late asthmatic response en-keyword=leukotrienes kn-keyword=leukotrienes END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=231 end-page=238 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of Aspirin induced asthma Part 2. The clinical feature and sttack mechanism of Aspirin-induced asthma kn-title=アスピリン喘息の病態に関する研究 第2編 アスピリン喘息の臨床的並びに基礎的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clinical features and the attack mechanism of Aspirin-induced asthma (AIA) were studied in 31 AIA cases (9.3%) among 333 asthmatics. AIA was defined positve from the anamnesis or from a positive aspirin inhalation challenge test result. AIA had more severe asthma symptoms than non-AIA. Moreover. the frequency of nasal polyp in AIA patients was higher than that in non-AIA ones. To clarify the mechanism of AIA, the concentrations of plasma histamine and leukotrienes were measured before and after the aspirin inhalation challenge test. There was no difference in the plasma histamine leved between AIA and non-AIA patients. The concentrations of plasma histamine and leukotrienes were meaurred before and after addition of aspirin to the peripheral blood in vitro. There were no differnces in the plasma histamine or leukotriene levels between AIA and non-AIA patients. These findings suggest that the mast cell is less related to the mechanism of AIA. Therefore, it may be necessary to examine mediators other than histamine and leukotrienes. en-copyright= kn-copyright= en-aut-name=TsutsuiHideta en-aut-sei=Tsutsui en-aut-mei=Hideta kn-aut-name=筒井英太 kn-aut-sei=筒井 kn-aut-mei=英太 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=アスピリン kn-keyword=アスピリン en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=ヒスタミン kn-keyword=ヒスタミン en-keyword=ロイコトリエン kn-keyword=ロイコトリエン END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=223 end-page=229 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of Aspirin induced asthma Part 1. Establishment and its application of aspirin inhalation challenge test for a diagnostic method og Aspirin-induced asthma kn-title=アスピリン喘息の病態に関する研究 第1編 アスピリン吸入誘発試験による臨床診断法に検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To diagnose Aspirin-induced asthma (AIA) safely and steadily, we performed an inhalation challenge test with a solution of Aspirin DL-lysine (VenopyrinⓇ) in 35 bronchial asthmatics. This test was positive in 15 asthmatics including 12 symptomatic AIA cases. Three of the 23 symptomatic non-AIA patients, showed a positive reaction by aspirin inhalation. All 4 patients, who had a positive result in the aspirin oral challenge test, also showed a positive reaction in the aspirin inhalation challenge test. However, during the inhalation experiment there was no evidence of large attacks provoked by the aspirin oral challenge test, indicating the safety of the inhalation challange test. Thses findings suggest that the test may be important for prevention of progression of intractable asthma by detection of latent AIA patints. en-copyright= kn-copyright= en-aut-name=TsutsuiHideta en-aut-sei=Tsutsui en-aut-mei=Hideta kn-aut-name=筒井英太 kn-aut-sei=筒井 kn-aut-mei=英太 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=アスピリン kn-keyword=アスピリン en-keyword=水溶性アスピリン製剤 kn-keyword=水溶性アスピリン製剤 en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=吸入誘発試験 kn-keyword=吸入誘発試験 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=9-10 article-no= start-page=859 end-page=869 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ADF in the lung tissues of HTLV-I associated bronchiolo-alveolar disorder : HABA kn-title=HTLV-I 関連細気管支・肺胞異常症 (HABA) における肺組織中 ADF の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=ATL-derived factor (ADF) is an acid protein, molecular weight about 13KD, which is related to cell classification, activation, and various viral infections. The localization of ADF was studied in the lung tissues of HTLV-I associated bronchiolo-alveolar disorder : HABA, diffuse panbronchiolitis : DPB, and idiopathic interstitial pneumonia : IIP. The localization of ADF in the lung tissues was demonstrated by immunohistochemical staining with anti-ADF antibody as the first antibody, which was made by affinity purification. In all 4 cases of HABA, one of 6 cases of DPB, and two of 5 cases of IIP, staining of the lung tissue was positive. ADF was demonstrated in the bronchial epithelia, alveolar epithelia, vascular endothelia, and desquamative cells in HABA cases as the result of the study. ADF was also restrictively demonstrated in bronchial epithelia in DPB and IIP cases. The case of DPB in which ADF was demonstrated also showed positive HTLV-I related reaction. In conclusion, the localization of ADF in the lung tissues was demonstrated in HABA, DPB and IIP, suggesting immunological abnormalities based upon infections from HTLV-I or a related retrovirus. en-copyright= kn-copyright= en-aut-name=KitamuraTomoki en-aut-sei=Kitamura en-aut-mei=Tomoki kn-aut-name=北村智樹 kn-aut-sei=北村 kn-aut-mei=智樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=HTLV-I Associated Bronchiolo-alveolar Disorder : HABA kn-keyword=HTLV-I Associated Bronchiolo-alveolar Disorder : HABA en-keyword=ATL-derived factor : ADF kn-keyword=ATL-derived factor : ADF en-keyword=Diffuse panbronchiolitis kn-keyword=Diffuse panbronchiolitis en-keyword=Idiopathic interstitial pneumonia kn-keyword=Idiopathic interstitial pneumonia en-keyword=Anti HTLV-I antibody kn-keyword=Anti HTLV-I antibody END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=7-8 article-no= start-page=759 end-page=770 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of anti-IgE autoantibody in bronchial asthma kn-title=気管支喘息における血清抗 IgE 自己抗体の基礎的並びに臨床的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the pathogenesis of asthma especially intractable asthma, we measured the serum levels of anti-IgE autoantibody in 46 asthmatics and 39 healthy subjects, using solid-phase enzyme immunoassay. The serum levels of anti-IgE autoantibody in bronchial asthmatics were significantly higher than those in healthy subjects (p<0.01). The levels of anti-IgE autoantibody in 25 atopic asthmatics were also significantly higher than those in 19 non-atopic asthmatics (p<0.01). Futhermore, significant correlation was observed between the levels of anti-IgE autoantibody and serum IgE (r=0.576, p<0.01). House dust and Candida (p<0.01) specific IgE (RAST) positive asthmatics also tended to have higher serum levels of anti-IgE autoantibody. However, no significant relation was observed between the serum levels of anti-IgE autoantibody and the severity of asthma. Moreover, anti-IgE autoantibody was not significantly related to specific IgG subclass antibody or lymphocyte blastogenesis to mite and Candida, or with the numbers of eosinophils and basophils in peripheral blood. These findings suggest that anti-IgE autoantibody play an important role in the pathogenesis of bronchial asthma, especially atopic asthma associated with IgE-dependent mechanisms. en-copyright= kn-copyright= en-aut-name=YamagataKoichi en-aut-sei=Yamagata en-aut-mei=Koichi kn-aut-name=山縣浩一 kn-aut-sei=山縣 kn-aut-mei=浩一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=抗 IgE 自己抗体 kn-keyword=抗 IgE 自己抗体 en-keyword=アトピー型喘息 kn-keyword=アトピー型喘息 en-keyword=IgE 抗体 kn-keyword=IgE 抗体 en-keyword=IgG アイソタイプ抗体 kn-keyword=IgG アイソタイプ抗体 en-keyword=酵素抗体法 kn-keyword=酵素抗体法 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=1-2 article-no= start-page=145 end-page=162 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinicopatholgical studies on htpersensitivity pneumonitis : Cellular kinetics in bronchoalveolar lavage (BAL) fluid of the patients with hypersensitivity pneumonitis kn-title=過敏性肺臓炎の病態に関する研究ー気管支肺胞洗浄液中の細胞動態を中心にー en-subtitle= kn-subtitle= en-abstract= kn-abstract=The cellular components of bronchoalveolar lavage (BAL) fluids from 26 patients with hypersensitivity pneumonitis were analyzed with regard to the period of antigen exposure before BAL procedure. In the early phase of antigen exposure BAL fluids contained increased neutrophils as well as lymphocytes while a low percentage of neutrophils and a prominent increase of lymphocytes were observed in chronic antigen exposure. Furthermore, the in-creased neutrophils decreased rapidly after cessation of antigen exposure while lymphocytes decreased gradually. In the BAL fluids of patients with summer-type hypersensitivity pneumonitis, CD4+ percentages and CD4/CD8 rations were significantly decreased, but CD8+ percentages significantly increased during antigen exposure compared with that in healthy controls. However, the actual CD4+ cell counts in BAL fluids significantly increased while CD4+ percentage decreased. Thus, CD4+ as well as CD8+ may play important roles in the pathogenesis of hypersensitivity pneumonitis. Soluble IL-2 receptor (sIL-2R) levels in BAL fluids and serum obtained from patients with hypersensitivity pneumonitis, especially serum sIL-2R during the active phase, were signifi-cantly higher than those of normal controls, indicating that the elevated sIL-2R level reflect-ed a highly activated immune response. In relation to pulmonary fuction, the lympocyte percentage showed a significant inverse correlation with % TLC and PaCO2, while neutrophil percentage showed significant correlation with % TLC and inverse correlation with FEV 1.0%. These reaults suggest that neutrophilia in BAL fluids affects bronchobronchiolar disorders during the early phase, and lympocytosis in BAL fluids regulates organic changes of the lung in hypersensitivity pneumonitis. en-copyright= kn-copyright= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=過敏性肺臓炎 kn-keyword=過敏性肺臓炎 en-keyword=気管支肺胞洗浄法 kn-keyword=気管支肺胞洗浄法 en-keyword=Tリンパ球サブセット kn-keyword=Tリンパ球サブセット en-keyword=吸入誘発試験 kn-keyword=吸入誘発試験 en-keyword=肺機能 kn-keyword=肺機能 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=9-10 article-no= start-page=1025 end-page=1033 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199410 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A new asthma classification based on its pathophysiology using IgE antibody (RAST) and lymphocyte activation as parameters kn-title=気管支喘息における病態に基づく新しい病型分類に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To establish a new classification in bronchial asthma, antigen-induced immediate asthmatic response (IAR) and late asthmatic response (LAR) to mite and Candida were compared with antigen specific IgE antibody (IgE RAST) and lymphocyte blastogenesis (Ly-BL) in asthmatics. Half of asthmatics with a high score on mite IgE RAST could not be provoked to IAR, although almost all of patients with house dust-induced IAR showed a high score on mite IgE RAST. However, asthmatics with enhanced Ly-BL following exposure to mite and Candida showed highly provoked LAR by antigen inhalation, and LAR patients showed significantly enhanced Ly-BL by both antigens (p<0.01). Bronchial asthmatics were classified into the following 4 groups using those parameters ; A group (IgE RAST+, Ly-BL-), B group (IgE RAST+, Ly-BL+), C group (IgE RAST-, Ly-BL+), D group (IgE RAST-,Ly-BL-). Half of the patients with IAR belonged to the A and B groups, and almost all of the LAR patients were in the B or C group. Patients in the A group predominantly showed early onset, however patients in the B and C groups showed late onset. A and B group patients were mild or moderate asthmatics, but severe asthmatics belonged to the C and D groups. These data suggest that the C group showed only Ly-BL led LAR by "cell-mediated allergy" in late onset severe asthma. en-copyright= kn-copyright= en-aut-name=KimuraKazuhi en-aut-sei=Kimura en-aut-mei=Kazuhi kn-aut-name=木村和陽 kn-aut-sei=木村 kn-aut-mei=和陽 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=asthma classification kn-keyword=asthma classification en-keyword=lymphocyte blastogenesis kn-keyword=lymphocyte blastogenesis en-keyword=Candida kn-keyword=Candida en-keyword=house dust・mite kn-keyword=house dust・mite en-keyword=IgE RAST kn-keyword=IgE RAST END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=1-2 article-no= start-page=83 end-page=92 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Circulating eosinophil and basophil precursor cells in bronchial asthmatics kn-title=気管支喘息患者における末梢血中の好酸球・好塩基球前駆細胞の動態の関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the pathogensis of bronchial asthma, eosinophil and basophil precursor cells in peripheral blood were investigated in 28 patients with bronchial asthma (20 atopic and 8 non-stopic asthmatics) and 6 healthy subjects using in vitro colong forming assay with methylcellulose culture medium. There was no significant difference between the mean count of Eo-type colony in bronchial asthmatics and that in healthy subjects, although cases with high colony were more common in the asthma group. The Eo-type colony count was significantly higher in atopic asthmatics than in either non-atopic astmatics or healthy subjects. In contrast, the colony count in non-atopic asthmatics was significantly lower than that in healthy subjects. A significant correlation was found between the Eo-type colony count and peripheral blood eosinophil count in atopic asthmatics, but there was no correlation between the conlony count and peripherad blood basophil count. These finidings suggest that circulating eosinophil and basophil precuresor cells play an important role in the pathogenesis of atopic bronchial asthma. en-copyright= kn-copyright= en-aut-name=ArakiMasashi en-aut-sei=Araki en-aut-mei=Masashi kn-aut-name=荒木雅史 kn-aut-sei=荒木 kn-aut-mei=雅史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Bronchial asthma kn-keyword=Bronchial asthma en-keyword=eosinophil kn-keyword=eosinophil en-keyword=basophil kn-keyword=basophil en-keyword=colony kn-keyword=colony en-keyword=precursor cell kn-keyword=precursor cell END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=7-8 article-no= start-page=907 end-page=915 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Establishment of antigen specific T cell clones from asthmatic patients including evaluation of cytokine production kn-title=気管支喘息における抗原特異的 T cell clone の樹立とサイトカイン産生能に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the pathogenesis of bronchial asthma, we establishied T cell clones specific for Candida antigen and for mite antigen from the peripheral blood of three asthmatic patients. Flow cytometric analysis was performed on these clones. The surface phenotype of all clones was helper/inducer type. These clones were analyzed for the ability to produce interferon gammma (IFN-γ) and interleukin 4 (IL-4). The T cell clone established from tne patient who showed late asthmatic response (LAR) after bronchial inhalation of Candida, as well as the clones from the patient who showed IAR and LAR after inhalation of housedust mite, produced a higher amount of IFN-γ and lower amount of IL-4. The T cell clone established from the patient who were under corticosteroid therapy and showed IAR after inhalation of Candida produced lower amounts of IFN-γ and IL-4, which seemed to be inhibition of cytokine production from antigen specific T cell clone by corticosteroids. These findings indicate that T cell clones established from the patients who showed LAR produced a large amount of IFN-γ, suggesting that IFN-γ plays an important role in allergic reactions of LAR. en-copyright= kn-copyright= en-aut-name=MiyaharaNobuaki en-aut-sei=Miyahara en-aut-mei=Nobuaki kn-aut-name=宮原信明 kn-aut-sei=宮原 kn-aut-mei=信明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=antigen specific T cell clone kn-keyword=antigen specific T cell clone en-keyword=IFN-γ kn-keyword=IFN-γ en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=late asthmatic response (LAR) kn-keyword=late asthmatic response (LAR) END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=1-2 article-no= start-page=71 end-page=81 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the soluble interleukin-2 receptor in patients with bronchial asthma kn-title=気管支喘息におけるInterleukin-2 receptorに関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cytokine-mediated interactions among blood cells, especially T-lymphoctes, may be impor-tant in the regulation of airway inflammation in asthma. To investigate whether T-lymphocytes are related to disease activity in asthma, serum soluble interleukin-2 receptor (sIL-2R) levels were measured in 77 bronchial asthmatics and 19 healthy volunteers. The serum sIL-2R level was higher in asthmatics than in healthy controls (mean±SD ；449.8±225.5 vs. 323.2±123.9 U/ml ; p<0.01). However, sIL-2R levels were similar between atopic and non-atopic asthmatics (451.9±235.9 vs. 416.7±147.2 U/ml), and were also similar between severe and mild to moderate asthmatics (437.4±209.9 vs. 469.8±276.1 U.ml). Steroid-dependent intractable asthmatics treated with prednisolone st doses of 5-10 mg/day showd higher sIL-2R levels (470.1±257.9 U/ml) than asthmatics treated with the drug at doses below 5 mg/day (357.2±102.6 U/ml) and intractable asthmatics treated with the drug at doses above 10 mg/day (282.5±194.5 U/ml). There was a strong correlation (r=0.915 ; p<0.01) between percentage at IL-2R-positive helper T cells among peripheral white blood cells and the serum concentration of sIL-2R. The type Ⅳ cell-mediated immune response is considered to be related to the pathogenesis of asthman. Serum sIL-2R levels are thought to reflect the extent of T-lymphocyte activation in non-malignant disease, but the level is aiso influenced by steroid therapy. en-copyright= kn-copyright= en-aut-name=KozukaAkiko en-aut-sei=Kozuka en-aut-mei=Akiko kn-aut-name=小塚明子 kn-aut-sei=小塚 kn-aut-mei=明子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=難治性喘息 kn-keyword=難治性喘息 en-keyword=T細胞 kn-keyword=T細胞 en-keyword=IL-2R kn-keyword=IL-2R en-keyword=細胞反応型アレルギー kn-keyword=細胞反応型アレルギー END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=7-8 article-no= start-page=847 end-page=860 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The mechanism of human basophil activation through the low affinity IgG receptor (Fc γ RⅡ) : Analysis of calcium mobilization using a new flow cytometric method kn-title=低親和性 IgG レセプター（FcγRⅡ）を介するヒト好塩基球の活性化機序に関する研究―フローサイトメーターによるカルシウム動態の解析― en-subtitle= kn-subtitle= en-abstract= kn-abstract=A new method for flow cytometric analysis of calcium mobilization in human peripheral blood basophils without prior purification was developed. The method is based on dual color analysis of centrifugation-enriched mononuclear cell populations using fluo-3 and phycoerythrin (PE)-conjugated CD2, CD14, CD16, CD19 monoclonal antibodies (mAb) to stain contaminated cells. This technique allows the detection of fluo-3 fluorescence as a measure of an increase in the cytoplasmic free calcium concentration ([Ca(2+)]i) while simulataneously discriminating PE-mAb-unlabelled basophils. To clarify whether the human peripheral blood basophil is activated through the low affinity IgG receptor, Fc γ RⅡ, as well as the high affinity IgE receptor, Fc ε RⅠ, calcium mobilization after Fc γ RⅡ stimulation was analyzed by this method. After cross-linking of Fc γ RⅡ, transient [Ca(2+)]i elevation was observed but there was no apparent difference with interleukin-3(IL-3)-treated cells, and no significant histamine release was observed with or without short pre-incubation of IL-3. These findings suggest that the cross-linking of Fc γ RⅡ, not only Fc ε RⅠ, can activate human basophils which may result in mediator release other than histamine. en-copyright= kn-copyright= en-aut-name=SuwakiToshimitsu en-aut-sei=Suwaki en-aut-mei=Toshimitsu kn-aut-name=洲脇俊充 kn-aut-sei=洲脇 kn-aut-mei=俊充 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=basophils kn-keyword=basophils en-keyword=FcγRⅡ kn-keyword=FcγRⅡ en-keyword=fluo-3 kn-keyword=fluo-3 en-keyword=Ca(2+) mobilization kn-keyword=Ca(2+) mobilization END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=1-2 article-no= start-page=51 end-page=60 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The production of platelet activating factor (PAF) from neutrophils in bronchial asthmatics kn-title=気管支喘息における血小板活性化因子の役割に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It was recently suggested that chemical mediators such as leukotrienes and PAF are more important in the pathogenesis of bronchial asthma than histamine. In this study, to clarify the role of PAF in bronchial asthma, I measured PAF activity derived from human neutrophils by the platelet aggregation tachnique and evaluated this activity in relation to the clinical features of brochial asthma. Neutrophils were separated from heparinized venous blood of 34 bronchial asthmatics and 11 healthy subjects. After suspension at 6×10(6) cells/ml, the cells were treated with 5μg/ml Ca ionophore A23187 for 5 minutes. PAF was extracted from the cell suspension using chloroform, and the activity was measured with an aggregometer using rabbit platelets. PAF activaty was significantly higher (p<0.05) in asthmatics (8.3±6.9 pmol/1×10(6) cells) than in healthy subjects (4.1±3.2 pmol/1×10(6) cells), and tended to increase in steroid-independent asthmatics rather than in steroid-dependent asthma patients. However, there was no difference in PAF production between atopic and non-atopic asthmatics, or between the early and late onset asthmatics. PAF production was increased in patients with severe airway hypersensitivity. These finding suggest that PAF plays an important role in the development and exacerbation of asthma. en-copyright= kn-copyright= en-aut-name=TsujiMitsuaki en-aut-sei=Tsuji en-aut-mei=Mitsuaki kn-aut-name=辻光明 kn-aut-sei=辻 kn-aut-mei=光明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=血小板活性化因子 kn-keyword=血小板活性化因子 en-keyword=好中球 kn-keyword=好中球 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=7-8 article-no= start-page=825 end-page=835 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The role of eicosanoids in airway hyperresponsiveness of chronic asthma using an animal model kn-title=連日抗原吸入による実験的慢性喘息におけるEicosanoidsの役割に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To elucidate the cause of severe asthma in adults, an animal model of chronic asthma was established in guinea pig sensitized by intraperitoneal injection of Ascaris suum and inhalation of the antigen repeated ten times. Then airway hyperresponsiveness, inflammatory cells and eicosanoids in the bronchoalveolar lavage fluid (BALF) and peripheral blood were examined. Airway responsiveness was acquired after inhalation of the antigen. Two types of airway responsiveness were observed ; accerelating-group and recovering-group. Total cell count and numbers of eosinophils and neutrophils in the BALF were significantly increased in the accerelating-group compared with the recovering-group and the control-group. The TXB2 level in the BALF was increased in the accerelating-group, and the LTB4 level in the BALF and peripheral blood were also increased in the accerelating-group. These findings suggest that the airway hyperresponsiveness is caused by eicosanoids, such as thromboxanes and leukotrienes produced by some inflammatory cells which are organized by activated lymphocytes as well as mast cell-basophils. en-copyright= kn-copyright= en-aut-name=TsujiAkihito en-aut-sei=Tsuji en-aut-mei=Akihito kn-aut-name=辻晃仁 kn-aut-sei=辻 kn-aut-mei=晃仁 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Ascaris suum kn-keyword=Ascaris suum en-keyword=guinea pig kn-keyword=guinea pig en-keyword=eicosanoids kn-keyword=eicosanoids en-keyword=chronic asthma kn-keyword=chronic asthma en-keyword=bronchoalveolar lavage kn-keyword=bronchoalveolar lavage END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=1-2 article-no= start-page=23 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=T-cell subsets in lung tissue and BALF from patients with interstitial pneumonia kn-title=各種間質性肺疾患における BAL 液並びに肺組織中 T-cell subset の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The cellular components in bronchoalveolar lavage fluids (BALF) and biopsied lung tissues of patients with various types of interstitial pneumonia were analyzed to clarify cellular kinetics in the lung. The T-cell subsets of lymphocytes in BALF and biopsied lung tissues were examined in 7 cases of hypersensitivity pneumonitis (HP), 2 cases of sarcoidosis (Sar), one case of idiopathic interstitial pneumonia (IIP) and 2 cases of rheumatoid arthritis with interstitial pneumonia (RA+IP). The T-cell subsets in BALF were analyzed by flow cytometry and the T-cell subsets in lung tissue were detected in frsh frozen and thin-sliced specimens using an avidine-biotine complex (ABC) kit. The mean CD4/CD8 ratio in BALF was 0.36 in HP, 3.1 in Sar, 1.07 in IIP and 2.59 in RA+IP, while the mean CD4/CD8 ratio in lung tissues was 0.52 in HP, 2.59 in Sar, 1.11 in IIP and 2.25 in RA+IP, respectively. The ratios of CD4/CD8 in BALF and lung tissues from patients with these various interstitial pneumonia showed a positive correlation. Significant correlation was seen between CD4/CD8 rations of the alveolar portion findings indicate that BAF findings reflect the changes in the lung tissues, although BALF might reflect only a part of the changes in the whole lung. en-copyright= kn-copyright= en-aut-name=NambaJiro en-aut-sei=Namba en-aut-mei=Jiro kn-aut-name=難波次郎 kn-aut-sei=難波 kn-aut-mei=次郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=bronchoalveolar lavage (BAL) kn-keyword=bronchoalveolar lavage (BAL) en-keyword=transbronchial lung biopsy (TBLB) kn-keyword=transbronchial lung biopsy (TBLB) en-keyword=immunoperoxidase staining kn-keyword=immunoperoxidase staining en-keyword=T-cell subset kn-keyword=T-cell subset END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=7-8 article-no= start-page=789 end-page=798 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Human T-lymphotropic virus type-Ⅰinfection and pulmonary fibrosing changes in patients with lung cancer kn-title=肺癌患者における HTLV-Ⅰ感染と間質性肺病変に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Thirty-one patients with lung cancer in Okinawa known as HTLV-Ⅰendemic area, and 140 patients in Okayama were evaluated in regard to HTLV-Ⅰinfection and iterstitial pulmonary shadows. The presence of HTLV-Ⅰinfection was examined by the polymerase chain reaction (PCR) method in peripheral blood mononuclear cells, and indirect immunofluorescent (IF) assay in sera. Interstitial pulmonary shadows on the chest roentgenograph, were classified according to the grade of fibrosis. The rate of HTLV-Ⅰinfection in patients with lung cancer was higher than that in healthy controls by IF assay in both districts. The rate of anti-HTLV-Ⅰantibody was higher in lung cancer patients with severe fibrosis than in those with milder fibrosis, but the grade of fibrosis and existence of pX gene had no relation in Okinawa or in Okayama. The incidence of patients with anti-HTLV-Ⅰantibody was higher in patients with adenocarcinoma and squamous cell carcinoma than in those with small cell carcinoma. These findings suggested that HTLV-Ⅰinfection was closely involved in some patients with non-small cell lung cancer having intersitital pulmonary shadows. en-copyright= kn-copyright= en-aut-name=NanbaSeiji en-aut-sei=Nanba en-aut-mei=Seiji kn-aut-name=難波靖治 kn-aut-sei=難波 kn-aut-mei=靖治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=肺癌 kn-keyword=肺癌 en-keyword=びまん性間質性肺病変 kn-keyword=びまん性間質性肺病変 en-keyword=polymerase chain reaction kn-keyword=polymerase chain reaction en-keyword=間接蛍光抗体法 kn-keyword=間接蛍光抗体法 en-keyword=HTLV-Ⅰ kn-keyword=HTLV-Ⅰ END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=7-8 article-no= start-page=743 end-page=750 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the occurrence of bronchial asthma Part 2. Lymphocytes activated by Cytomegalovirus kn-title=気管支喘息の発症に関する研究 第2編 喘息患者におけるサイトメガロウイルス抗原によるリンパ球幼若化反応の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The possible role of virus infection in the occurrence and attack of asthma was examined by measuring the lymphocyte transformation test to CMV in 44 asthmatic and 14 healthy subjects and analyzed their relation to the clinical parameters. CMV-induced lymphocyte reactivity (CMV-LR) in adult asthmatics was significantly higher than that in the healthy controls. A positive correlation was observed between CMV-LR titer and CMV-complement fixation (CMV-CF) antibody titers (r=0.35). In adult asthmatics, the CMV-LR in the high IgE titer (100U/ml≦) group was significantly higher than that in the low IgE titer (<100U/ml) group. These findings suggest that CMV is an important factor in the pathogenesis of adult asthma mediated by lymphocytes and probably IgE, although the precise mechanism in still unknown. en-copyright= kn-copyright= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=viral infection kn-keyword=viral infection en-keyword=Cytomegalovirus kn-keyword=Cytomegalovirus en-keyword=IgE kn-keyword=IgE en-keyword=CMV-LTT kn-keyword=CMV-LTT END start-ver=1.4 cd-journal=joma no-vol=111 cd-vols= no-issue=3-8 article-no= start-page=95 end-page=104 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Stress raises intraocular pressure in rabbits kn-title=ストレスが眼圧に与える影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose. To test whether encagement and volume load as stressors influence the intraocular pressure in rabbits. Method. Rabbits were encaged for an hour in a horizontally-plastic tube with an internal diameter of 13.2 cm and a length of 33.2cm. After the encagement, rabbits received a rapid intraveonus drip infusion of 5% glucose solution, 20 ml per kilogram of body weight, for 5-6 minutes. All experiments were performed at the same time of day. Results. The intraocular pressure after encagement (11.2±3.0mmHg as a mean and standard deviation) was significantly higher compared with that of control rabbits without encagement (9.2±1.0mmHg, Student t-test,p=0.046). This differnce became signifficantly larger when volume load was exerted on both groups of rabbits (p=0.0007). Serum levels of cortisol, adrenaline, and nordrenaline were significantly elevated afte encagement (n=6, p=0.0002, p=0.027, p=0.030, respectively). Venous pressure of the ear tended to increase in rabbits after encagement (15.8±3.1mmHg) compared with that of control rabbits (8.5±2.3mmHg,p=0.11), and the difference became significant when volume load was placed on each group of rabbits (p=0.021). Conclusions.Encagement, especially in combination with volume losd, increased the intraocular pressure in rabbits. The elevation of peripheral venous pressure caused by an increase in serum catecholamines would underlie the elevation of intraocular pressure proh-ably through the increased outflow resistance. en-copyright= kn-copyright= en-aut-name=MiyazakiYoshinori en-aut-sei=Miyazaki en-aut-mei=Yoshinori kn-aut-name=宮﨑義則 kn-aut-sei=宮﨑 kn-aut-mei=義則 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部眼科学講座 en-keyword=stress kn-keyword=stress en-keyword=intraocular pressure kn-keyword=intraocular pressure en-keyword=cortisol kn-keyword=cortisol en-keyword=catecholamines kn-keyword=catecholamines en-keyword=venus pressure kn-keyword=venus pressure END start-ver=1.4 cd-journal=joma no-vol=112 cd-vols= no-issue=3-8 article-no= start-page=47 end-page=64 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on factors relating to oral malodor and preventive measures among the elderly kn-title=要介護高齢者における口臭とその関連要因及び予防対策に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=One hundred ten elderly with disabilities in institutions or receiving home care were selected and informed. This study focused on oral malodor and discusses consent was obtained the relationship between oral malodor and the state of dental health and oral hygiene in the elderly with disabilities. ADL of the elderly with disabilities (rank J, A, B, C, settled by National Health Administration in Japan) were 8.2% at rank J, 28.2% at rank A, 42.7% at rank B and 20.9% at rank C, respectively. The incident rate of swallowing pneumonitis, fever and bedsores were low. Accordingly, physical and mental conditions were comparatively preferable. Tooth and periodontal conditions were comparablye to nationwide results. 1. The elderly in poor ADL had marked oral malodor compared with those in good health. 2. The elderly who required assistance to eat or had special dietary requirements had marked oral malodor. 3. The elderly who had normal oral functions and the ability to take care of their own oral hygiene had markedly less oral malodor. 4. The elderly who had poor oral hygiene exhibitings thick tongue coating and positive results in a Candida albicans culture test, had marked oral malodor. 5. Using, the multivariate statistical analysis of Hayashi methodsⅡ, the coefficient of correlation between the state of oral malodor and 27 variables was obtained. 1) The study obtained trustworthy values that discriminate analysis 92.7% and correlation ratio is 0.53. 2) The variables related to severe oral malodor, extracted by the multivariate statistical analysis in descending order, were: "low level of ADL in gargling and denture brushing", "cigarette smoking", "speech disabilities", "unsatisfactory mastication", "need for special dietary care", "oral druyness", "gingivitis", "soft diet of side dish", "living in a special institution caring for the elderly", "thick tongue coating", and "a positive Candida albicans culture test", respectively. 3) The items related with comparatively comfortable or bearable oral malodor, extracted by the multivariate statistical analysis in descending order were : "satisfactory mastication", "home care", "healthy or poor eyesight", "difficulty in mastication", "being able to independently remove, dentures", "a negative Candida albicans culture test", "no oral dryness", "independents in selecting diet", "comfortable gingival condition", "being dependent on others for tooth-brushing" and "preferable tongue coating", respectively. 4) For the effective preventive countermeasures of oral malodor, ADL of oral health, caring circumstances and hygiene of gingiva/tongue should be focused on rather than dental hygiene itself. en-copyright= kn-copyright= en-aut-name=EgusaMasahiko en-aut-sei=Egusa en-aut-mei=Masahiko kn-aut-name=江草正彦 kn-aut-sei=江草 kn-aut-mei=正彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部衛生学講座 en-keyword=Elederly with disabilities kn-keyword=Elederly with disabilities en-keyword=Oral malodor kn-keyword=Oral malodor en-keyword=Preventive countermeasure kn-keyword=Preventive countermeasure en-keyword=Related factor kn-keyword=Related factor en-keyword=Multivariate statistical analysis kn-keyword=Multivariate statistical analysis END start-ver=1.4 cd-journal=joma no-vol=113 cd-vols= no-issue=3 article-no= start-page=279 end-page=284 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20011231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The surgical management of sex reassignment surgery and its options kn-title=性同一性障害に対する包括的医療の実践 en-subtitle= kn-subtitle= en-abstract= kn-abstract=GENDER IDENTITY DISORDER (GID) is a unique human condition that is classified behaviorally and treated medically with hormones and surgery in the severe form. This condition has been and still somewhat remains controversial by religious belief, social institutions and health care delivery systems. We described the surgical management of transsexuals, so called SEX REASSGINMENT SURGERY (SRS) and showed the team for gender treatment, GENDER CLINIC. A gender treatment team composing staff members from the Psychiatric, Plastic Surgery, Urology, Obstetric/Gynecological Surgery, and the Social Service, was established at the Hospital of Okayama University Medical schools in 1999. Female-to-Male procedures include mastectomy, phalloplasty, Phalloplasty are completion and an appurtenance, something pleasing to others. Male-to-Female program includes the genital surgery. The genital change surgery consists of the penile inversion, orchiectomy, vaginoplasty. Other prodedures include reduction thyroid chondroplasty, hair transplant, voice change, laryngeal surgery, epilation with the laser. SRS is the only effective treatment available today in the management of GID. The aesthetic and functional results achievable from various procedures are generally satisfactory and are acceptable to the patients. On the other hand, we should remember that the numerous steps of information for SRS will be required. en-copyright= kn-copyright= en-aut-name=TakahashiYoshio en-aut-sei=Takahashi en-aut-mei=Yoshio kn-aut-name=高橋義雄 kn-aut-sei=高橋 kn-aut-mei=義雄 aut-affil-num=1 ORCID= en-aut-name=NambaYuuzaburou en-aut-sei=Namba en-aut-mei=Yuuzaburou kn-aut-name=難波祐三郎 kn-aut-sei=難波 kn-aut-mei=祐三郎 aut-affil-num=2 ORCID= en-aut-name=KishimotoKouji en-aut-sei=Kishimoto en-aut-mei=Kouji kn-aut-name=岸本晃司 kn-aut-sei=岸本 kn-aut-mei=晃司 aut-affil-num=3 ORCID= en-aut-name=KoshimaIsao en-aut-sei=Koshima en-aut-mei=Isao kn-aut-name=光嶋勲 kn-aut-sei=光嶋 kn-aut-mei=勲 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院 形成外科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院 形成外科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院 形成外科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院 形成外科 en-keyword=gender identity disorder kn-keyword=gender identity disorder en-keyword=transsexualism kn-keyword=transsexualism en-keyword=sex reassignment surgery kn-keyword=sex reassignment surgery en-keyword=sex change kn-keyword=sex change END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=1 article-no= start-page=9 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=心不全における酸化ストレスの関与：基礎的ならびに臨床的検討 ―岡山大学医学賞（結城賞）を受賞して― en-subtitle= kn-subtitle= en-abstract= kn-abstract=心不全患者において血中の過酸化脂質の上昇などが報告され，活性酸素による酸化ストレスの関与が示唆されている．そこで，心筋が実際に活性酸素を発生するかどうかを，活性酸素を検出する蛍光プローブを用いてラットの培養心筋細胞において検討した．心不全増悪因子であるアンジオテンシンIIおよびtumor necrosis factor(TNF)-alphaを加えると心筋細胞で濃度依存性に活性酸素が発生した．さらにヒトの不全心筋においても実際に酸化ストレスの発生が増強しているかを検討した．過酸化脂質の代謝産物で，有害なアルデヒドである4-Hydroxy-2-nonenal(HNE)によって修飾された蛋白質を免疫染色にて調べたところ，拡張型心筋症患者の心筋において正常心機能者に比べ5倍以上増加していた．さらにβ遮断薬(Carvedilol)により治療を行ったところ心機能の改善とともに，HNE修飾蛋白質が40%低下した．以上の一連の研究により， 活性酸素による酸化ストレスの発生が不全心筋において増強しており，その抑制が心不全治療のターゲットの一つになりうることを明らかにした． en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中村一文 kn-aut-sei=中村 kn-aut-mei=一文 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=草野研吾 kn-aut-sei=草野 kn-aut-mei=研吾 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=垣下幹夫 kn-aut-sei=垣下 kn-aut-mei=幹夫 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三浦綾 kn-aut-sei=三浦 kn-aut-mei=綾 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=久松研一 kn-aut-sei=久松 kn-aut-mei=研一 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西井伸洋 kn-aut-sei=西井 kn-aut-mei=伸洋 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=伴場主一 kn-aut-sei=伴場 kn-aut-mei=主一 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡邊敦之 kn-aut-sei=渡邊 kn-aut-mei=敦之 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤尾栄起 kn-aut-sei=藤尾 kn-aut-mei=栄起 aut-affil-num=9 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=宮地克維 kn-aut-sei=宮地 kn-aut-mei=克維 aut-affil-num=10 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=永瀬聡 kn-aut-sei=永瀬 kn-aut-mei=聡 aut-affil-num=11 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=森田宏 kn-aut-sei=森田 kn-aut-mei=宏 aut-affil-num=12 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=斎藤博則 kn-aut-sei=斎藤 kn-aut-mei=博則 aut-affil-num=13 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=江森哲郎 kn-aut-sei=江森 kn-aut-mei=哲郎 aut-affil-num=14 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=浅沼幹人 kn-aut-sei=浅沼 kn-aut-mei=幹人 aut-affil-num=15 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=宮崎正博 kn-aut-sei=宮崎 kn-aut-mei=正博 aut-affil-num=16 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中村陽一 kn-aut-sei=中村 kn-aut-mei=陽一 aut-affil-num=17 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松原広己 kn-aut-sei=松原 kn-aut-mei=広己 aut-affil-num=18 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=伏見和郎 kn-aut-sei=伏見 kn-aut-mei=和郎 aut-affil-num=19 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=豊國伸哉 kn-aut-sei=豊國 kn-aut-mei=伸哉 aut-affil-num=20 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大江透 kn-aut-sei=大江 kn-aut-mei=透 aut-affil-num=21 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科 循環器内科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯学総合研究科 循環器内科 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯学総合研究科 循環器内科 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯学総合研究科 循環器内科 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯学総合研究科 循環器内科 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯学総合研究科 循環器内科 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯学総合研究科 循環器内科 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯学総合研究科 循環器内科 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯学総合研究科 循環器内科 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯学総合研究科 循環器内科 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯学総合研究科 循環器内科 affil-num=12 en-affil= kn-affil=岡山大学大学院医歯学総合研究科 循環器内科 affil-num=13 en-affil= kn-affil=岡山大学大学院医歯学総合研究科 循環器内科 affil-num=14 en-affil= kn-affil=岡山大学大学院医歯学総合研究科 循環器内科 affil-num=15 en-affil= kn-affil=岡山大学大学院医歯学総合研究科 神経情報学 affil-num=16 en-affil= kn-affil=岡山大学大学院医歯学総合研究科 細胞生物学 affil-num=17 en-affil= kn-affil=松山市民病院循環器内科 affil-num=18 en-affil= kn-affil=国立病院岡山医療センター循環器科 affil-num=19 en-affil= kn-affil=北陸先端科学技術大学院大学ナノマテリアルテクノロジーセンター affil-num=20 en-affil= kn-affil=京都大学大学院医学研究科病態生物医学 affil-num=21 en-affil= kn-affil=岡山大学大学院医歯学総合研究科 循環器内科 en-keyword=4-Hydroxy-2-nonenal kn-keyword=4-Hydroxy-2-nonenal en-keyword=酸化ストレス kn-keyword=酸化ストレス en-keyword=心不全 kn-keyword=心不全 en-keyword=β遮断薬 kn-keyword=β遮断薬 END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=3 article-no= start-page=219 end-page=224 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Characterization and usefulness of a monoclonal antibody against human herpesvirus-7 DNA polymerase processivity factor kn-title=ヒトヘルペスウイルス7型のDNA ポリメラーゼサブユニットに対する単クローン抗体の性状と有用性 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A monoclonal antibody (MAb), IK17, was developed and found useful for the analysis of human herpesvirus-7 (HHV7) genome replication. In Western blot analysis, the MAb IK17 specifically detected an HHV7 DNA polymerase subunit,U27 protein,expressed in both Escherichia coli (E.Coli)and HHV7-infected cells.Analysis by the same method of truncated U27 proteins expressed in E. Coli demonstrated that the MAb IK17 recognizes an epitope between amino acid 1 and 133 of the U27 protein.The indirect immunofluorescence (IF)method with MAb IK17 detected an unexpected reduction of U27 protein in the infected cells that were treated with a viral DNA polymerase inhibitor,phosphonoacetic acid (PAA),although no reduction of U27 mRNA was observed in the cells by Northern blot analysis. The data suggest the possible usefulness of the MAb IK17 for obtaining clues to characterize an unknown feature of the U27 protein. Immunoprecipitation experiments with the MAb IK17 enabled to detect at least four U27 protein-associated phosphorylated polypeptides in addition to the U27 protein itself.The result indicates the usefulness of the MAb IK17 for qualitative and quantitative analysis of the U27 proteinassociated viral and cellular factors. These analyses contribute to elucidation of the HHV7 genome replication system. en-copyright= kn-copyright= en-aut-name=NambaHikaru en-aut-sei=Namba en-aut-mei=Hikaru kn-aut-name=難波ひかる kn-aut-sei=難波 kn-aut-mei=ひかる aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病原ウイルス学 en-keyword=ヒトヘルペスウイルス7型 (Human Herpesvirus-7) kn-keyword=ヒトヘルペスウイルス7型 (Human Herpesvirus-7) en-keyword=DNA polymerase processivity factor kn-keyword=DNA polymerase processivity factor en-keyword=単クローン抗体 (monoclonal antibody) kn-keyword=単クローン抗体 (monoclonal antibody) END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=209 end-page=210 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=<病院紹介>特定医療法人社団同仁会 金光病院 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=難波義夫 kn-aut-sei=難波 kn-aut-mei=義夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=地方都市における中心商業地の衰退化と再生への課題 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NaniwadaTakao en-aut-sei=Naniwada en-aut-mei=Takao kn-aut-name=難波田隆雄 kn-aut-sei=難波田 kn-aut-mei=隆雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ケモカインFractalkine/CX3CR1及び受容体CX3CR1陽性単球の慢性GVHDの病態への関与 kn-title=Predominant Infiltration of Monocytes in Chronic Graft-Versus-Host Disease en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NanbaNoriko en-aut-sei=Nanba en-aut-mei=Noriko kn-aut-name=難波寛子 kn-aut-sei=難波 kn-aut-mei=寛子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=97 cd-vols= no-issue=1 article-no= start-page=1 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Purification, Characterization and Crystal Structure of Isoamylase from Thermophilic Bacteria Rhodothermus marinus kn-title=海産性好熱性細菌 Rhodothermus marinus 由来イソアミラーゼ の精製，性質検討及びＸ線結晶構造解析 en-subtitle= kn-subtitle= en-abstract=Rhodothermus marinus 由来イソアミラーゼ遺伝子を組み込んだプラスミド pBX２を使用し，大腸菌 Top10株を形質転換し，16時間の前培養，24時間の本培養後，菌体破砕し，得られた無細胞抽出液を熱処理（80℃，10 min），50ｵ硫安分画，陰イオン交換カラムクロマトグラフィー（DEAEﾝトヨパール），ハイドロキシアパタイトカラムクロマトグラフィーに供して本酵素の精製を行った．本精製酵素の性質検討を行った結果，本酵素の最適反応温度は70℃，pH４であり，また本酵素は60℃で１時間処理しても活性が低下することが無く，Pseudomonas amyloderamosa 由来イソアミラーゼよりも高い耐熱性を有することが判明した．本酵素の結晶化・X線結晶構造解析を行った結果，本酵素は P. amyloderamosa 由来イソアミラーゼと同様Ｎドメイン・ＡドメインＣドメインの３つのドメインから構成されており，活性残基（Ｄ359，Ｅ395，Ｄ467）など活性中心付近のアミノ酸残基も P. amyloderamosa 由来イソアミラーゼと同様，高度に保存されていた．本酵素の熱安定性が P. amyloderamosa 由来イソアミラーゼよりも高 い要因として，P. amyloderamosa 由来イソアミラーゼよりもループの長さが全体的に短いことと，カルシウムイオン結合サイトの欠如が挙げられた．今後さらに構造解析を進めることにより，本酵素の熱安定性機構，反応 機構など更なる知見が得られることが期待される． kn-abstract=The isoamylase gene from Rhodothermus marinus was cloned into and expressed in Escherichia coli Top 10. As a result of characterization of purified R. marinus isoamylase. the enzyme had an optimum pH of 4.0 and optimum temperature of 70℃. Thermal inactivation studies of the purified R. marinus isoamylase revealed the enzymatic activity to be uninfluenced after one hour incubation at 60℃. These results suggest that R. marinus isoamylase has high thermostability. The crystallization and crystal structure analysis of R. marinus isoamylase was performed. The three-dimensional structure at 1.9Å resolution was determined in complex with the panose. R. marinus isoamylase is composed of three domains N, A and C, and, has a (β/α)8-barrel in domain A. The secondary structural alignments of the R. marinus isoamylase and P. amyloderamosa isoamylase was carried out. They have the four active-site consensus regions characteristic of the α-amylase family. And the essential residue of the α-amylase family (D359, E395, and D467) was conserved in these enzymes. R. marinus isoamylase has shorter loops than P. amyloderamosa isoamylase. And R. marinus isoamylase had no Ca2+ binding site. These results are thought to be factors of thermostability of R. marinus isoamylase. en-copyright= kn-copyright= en-aut-name=TachibanaAkiko en-aut-sei=Tachibana en-aut-mei=Akiko kn-aut-name=立花亜紀子 kn-aut-sei=立花 kn-aut-mei=亜紀子 aut-affil-num=1 ORCID= en-aut-name=TamuraTakashi en-aut-sei=Tamura en-aut-mei=Takashi kn-aut-name=田村隆 kn-aut-sei=田村 kn-aut-mei=隆 aut-affil-num=2 ORCID= en-aut-name=ImadaKatsumi en-aut-sei=Imada en-aut-mei=Katsumi kn-aut-name=今田勝巳 kn-aut-sei=今田 kn-aut-mei=勝巳 aut-affil-num=3 ORCID= en-aut-name=KinoshitaMiki en-aut-sei=Kinoshita en-aut-mei=Miki kn-aut-name=木下実紀 kn-aut-sei=木下 kn-aut-mei=実紀 aut-affil-num=4 ORCID= en-aut-name=NambaKeiichi en-aut-sei=Namba en-aut-mei=Keiichi kn-aut-name=難波啓一 kn-aut-sei=難波 kn-aut-mei=啓一 aut-affil-num=5 ORCID= en-aut-name=TsutsumiNoriko en-aut-sei=Tsutsumi en-aut-mei=Noriko kn-aut-name=堤紀子 kn-aut-sei=堤 kn-aut-mei=紀子 aut-affil-num=6 ORCID= en-aut-name=HashidaMiyoko en-aut-sei=Hashida en-aut-mei=Miyoko kn-aut-name=橋田みよ子 kn-aut-sei=橋田 kn-aut-mei=みよ子 aut-affil-num=7 ORCID= en-aut-name=SakaguchiHiromichi en-aut-sei=Sakaguchi en-aut-mei=Hiromichi kn-aut-name=坂口博脩 kn-aut-sei=坂口 kn-aut-mei=博脩 aut-affil-num=8 ORCID= en-aut-name=InagakiKenji en-aut-sei=Inagaki en-aut-mei=Kenji kn-aut-name=稲垣賢二 kn-aut-sei=稲垣 kn-aut-mei=賢二 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=大阪大学 affil-num=4 en-affil= kn-affil=大阪大学 affil-num=5 en-affil= kn-affil=大阪大学 affil-num=6 en-affil= kn-affil=ノボザイムズ ジャパン affil-num=7 en-affil= kn-affil=ノボザイムズ ジャパン affil-num=8 en-affil= kn-affil=ノボザイムズ ジャパン affil-num=9 en-affil= kn-affil=岡山大学 en-keyword=isoamylase kn-keyword=isoamylase en-keyword=Rhodothermus marinus kn-keyword=Rhodothermus marinus en-keyword=crystal structure kn-keyword=crystal structure en-keyword=thermostability kn-keyword=thermostability END start-ver=1.4 cd-journal=joma no-vol=3 cd-vols= no-issue= article-no= start-page=75 end-page=79 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Efficacy of a check list and a video tape in learning the aseptic method kn-title=無菌操作技術教育におけるチェックリストとビデオ使用による自己学習効果 ―自己評価能力を中心にして― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Basic nursing care includes many kinds of techniques. The aseptic method is especially very important technique among them. We gave students check lists and video tapes in order to master the method by themselves and obtained following results. 1) Students can properly assess their techniques of nursing care by using a check list and watching a video. 2) Students can assess by themselves more effectively in a simple and easy action. 3) Even for a complicated action, students can make better their self-assessments by watching a video. en-copyright= kn-copyright= en-aut-name=IkedaToshiko en-aut-sei=Ikeda en-aut-mei=Toshiko kn-aut-name=池田敏子 kn-aut-sei=池田 kn-aut-mei=敏子 aut-affil-num=1 ORCID= en-aut-name=KondoMasuko en-aut-sei=Kondo en-aut-mei=Masuko kn-aut-name=近藤益子 kn-aut-sei=近藤 kn-aut-mei=益子 aut-affil-num=2 ORCID= en-aut-name=OhtaNiwa en-aut-sei=Ohta en-aut-mei=Niwa kn-aut-name=太田にわ kn-aut-sei=太田 kn-aut-mei=にわ aut-affil-num=3 ORCID= en-aut-name=TokunagaJunko en-aut-sei=Tokunaga en-aut-mei=Junko kn-aut-name=徳永順子 kn-aut-sei=徳永 kn-aut-mei=順子 aut-affil-num=4 ORCID= en-aut-name=NakanishiYoshiko en-aut-sei=Nakanishi en-aut-mei=Yoshiko kn-aut-name=中西代志子 kn-aut-sei=中西 kn-aut-mei=代志子 aut-affil-num=5 ORCID= en-aut-name=TakataSetuko en-aut-sei=Takata en-aut-mei=Setuko kn-aut-name=高田節子 kn-aut-sei=高田 kn-aut-mei=節子 aut-affil-num=6 ORCID= en-aut-name=NanbaJun en-aut-sei=Nanba en-aut-mei=Jun kn-aut-name=難波純 kn-aut-sei=難波 kn-aut-mei=純 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=4 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=5 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=6 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=7 en-affil= kn-affil=前岡山大学医療技術短期大学部看護学科 en-keyword=自己評価 kn-keyword=自己評価 en-keyword=無菌操作 kn-keyword=無菌操作 en-keyword=VTR kn-keyword=VTR en-keyword=チェックリスト kn-keyword=チェックリスト END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=89 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=19920205 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Effects of the Introduction of the Video-tape Recorder to Basic Nursing Care Education - The Use of Video-tapes taken at the Practice of Aseptic Handling Technique by Students - kn-title=基礎看護技術教育へのビデオ教材利用の効果 ―学生の無菌操作時の録画テープ活用― en-subtitle= kn-subtitle= en-abstract= kn-abstract=The Video-tape recorder was introduced to tape the scene of a preliminary test of students' practice to aseptically handle syringes. These video-tapes taken were released to students to watch and to refer back to for their self-study. Students were consequently divided into four groups on how to utilize the video-tapes. The scores of the preliminary and final test and their differences were statistically compared by the groups. The results suggested that the use of video-tapes is effective for the achievement of skills in delicate techniques of nursing care and especially the utilization upon their own initiative leads to a more successful result. en-copyright= kn-copyright= en-aut-name=OhtaNiwa en-aut-sei=Ohta en-aut-mei=Niwa kn-aut-name=太田にわ kn-aut-sei=太田 kn-aut-mei=にわ aut-affil-num=1 ORCID= en-aut-name=KondoMasuko en-aut-sei=Kondo en-aut-mei=Masuko kn-aut-name=近藤益子 kn-aut-sei=近藤 kn-aut-mei=益子 aut-affil-num=2 ORCID= en-aut-name=IkedaToshiko en-aut-sei=Ikeda en-aut-mei=Toshiko kn-aut-name=池田敏子 kn-aut-sei=池田 kn-aut-mei=敏子 aut-affil-num=3 ORCID= en-aut-name=TokunagaJunko en-aut-sei=Tokunaga en-aut-mei=Junko kn-aut-name=徳永順子 kn-aut-sei=徳永 kn-aut-mei=順子 aut-affil-num=4 ORCID= en-aut-name=NakanishiYoshiko en-aut-sei=Nakanishi en-aut-mei=Yoshiko kn-aut-name=中西代志子 kn-aut-sei=中西 kn-aut-mei=代志子 aut-affil-num=5 ORCID= en-aut-name=NanbaJun en-aut-sei=Nanba en-aut-mei=Jun kn-aut-name=難波純 kn-aut-sei=難波 kn-aut-mei=純 aut-affil-num=6 ORCID= en-aut-name=TakataSetuko en-aut-sei=Takata en-aut-mei=Setuko kn-aut-name=高田節子 kn-aut-sei=高田 kn-aut-mei=節子 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=4 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=5 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=6 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=7 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 en-keyword=無菌操作 kn-keyword=無菌操作 en-keyword=VTR kn-keyword=VTR en-keyword=学習効果 kn-keyword=学習効果 END start-ver=1.4 cd-journal=joma no-vol=1 cd-vols= no-issue= article-no= start-page=61 end-page=68 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=19910325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Factors Affecting Home Care of Elders Report 1. Support Expected by the Elderly and Family kn-title=高齢者の在宅ケアに関する要因の研究 第一報 老人および家族が期待する援助 en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the rapid increase of the elders in population in Japan after the 2nd world war, the arrangement of medical care for aged persons, both therapeutic and preventive, has become the serious social problem. To estimate the possibility of care at home and needs of elders and their family for public and volunteer services, questionnaire survey was carried out at Konko town in Okayama prefecture, Japan, in August 1990. More than half of the 105 elders older than 65 years and living alone (group A, 9 males and 96 females) replied to want to be cared for at home and 178 families with elders (group B) wanted to care for them at home. As for services they would wish to be offered when they would become bedridden at home, while group A wished to be visited and cared for by 'physician', 'home helper' and 'neighbor' in order of high rate group B 'physician', 'public health nurse' and 'nurse'. As for facility or assistance services, the former wanted 'purchasing, sweeping and washing', food delivery' and 'calling on' and the latter 'care consultation', 'assist of body bath' and 'economic aid'. Other supports or cares were also hopefully expected by both groups. The results shows that well-arrangement and promotion of a variety of constitional and personal support for home cares for elders in the community must be urged. en-copyright= kn-copyright= en-aut-name=OnoTsuruko en-aut-sei=Ono en-aut-mei=Tsuruko kn-aut-name=小野ツルコ kn-aut-sei=小野 kn-aut-mei=ツルコ aut-affil-num=1 ORCID= en-aut-name=ArakawaYasuko en-aut-sei=Arakawa en-aut-mei=Yasuko kn-aut-name=荒川靖子 kn-aut-sei=荒川 kn-aut-mei=靖子 aut-affil-num=2 ORCID= en-aut-name=OhtaNiwa en-aut-sei=Ohta en-aut-mei=Niwa kn-aut-name=太田にわ kn-aut-sei=太田 kn-aut-mei=にわ aut-affil-num=3 ORCID= en-aut-name=NanbaJun en-aut-sei=Nanba en-aut-mei=Jun kn-aut-name=難波純 kn-aut-sei=難波 kn-aut-mei=純 aut-affil-num=4 ORCID= en-aut-name=OhtaTakeo en-aut-sei=Ohta en-aut-mei=Takeo kn-aut-name=太田武夫 kn-aut-sei=太田 kn-aut-mei=武夫 aut-affil-num=5 ORCID= en-aut-name=ShimizuMasako en-aut-sei=Shimizu en-aut-mei=Masako kn-aut-name=清水昌子 kn-aut-sei=清水 kn-aut-mei=昌子 aut-affil-num=6 ORCID= en-aut-name=IshiiKiyoko en-aut-sei=Ishii en-aut-mei=Kiyoko kn-aut-name=石井希代子 kn-aut-sei=石井 kn-aut-mei=希代子 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=4 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=5 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=6 en-affil= kn-affil=金光町役場住民課 affil-num=7 en-affil= kn-affil=金光町役場住民課 en-keyword=Home Care kn-keyword=Home Care en-keyword=Family Care kn-keyword=Family Care en-keyword=the Elderly kn-keyword=the Elderly en-keyword=Support kn-keyword=Support END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue=1 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20001116 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Planning of Okayama University Graduate School of Medicine and Dentistry kn-title=岡山大学医歯学総合研究科大学院部局化の経緯 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NambaMasayoshi en-aut-sei=Namba en-aut-mei=Masayoshi kn-aut-name=難波正義 kn-aut-sei=難波 kn-aut-mei=正義 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部 END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue=1 article-no= start-page=121 end-page=129 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Preparation and Properties of ZnO Transparent Conductive Thin Films by Activated Reactive Evaporation Method kn-title=活性化反応蒸着法によるZnO系透明導電膜の作製と物性 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Zinc oxide films were prepared on silica glass substrates by the use of an r.f. activated reactive evaporation (ARE) method, and were examined by X-ray diffraction (XRD) and scanning electron microscope (SEM). The electrical conductivity of the films and the doping effect of Al ions were also investigated. XRD measurements indicate that the films were c-axis oriented and that an r.f. plasma of Zn and O was necessary for the ZnO film deposition. Substrate temperature, oxygen gas pressure, evaporation rate, r.f. power and Al doping amount affect the c-axis orientation, the growth rate, the microstructure of the films and electrical conductivity. Optimum conditions with a fine texture of the surface and having good ctystallinity as well as good conductivity (≒10(-4)Ω・cm) were as follows : the substrate temperature; 200℃, the total evaporation rate; 1.0Å/s, the oxygen pressure; 2.0×10(-4) Torr, the r.f. power; 250W and the Al evaporation rare ratio; 2～6%. The films with 1.0×10(-3)Ω・cm were prepared at 50℃ for the substrate temperature. en-copyright= kn-copyright= en-aut-name=FujiwaraTakashi en-aut-sei=Fujiwara en-aut-mei=Takashi kn-aut-name=藤原貴 kn-aut-sei=藤原 kn-aut-mei=貴 aut-affil-num=1 ORCID= en-aut-name=FujiiTatsuo en-aut-sei=Fujii en-aut-mei=Tatsuo kn-aut-name=藤井達生 kn-aut-sei=藤井 kn-aut-mei=達生 aut-affil-num=2 ORCID= en-aut-name=NanbaTokuro en-aut-sei=Nanba en-aut-mei=Tokuro kn-aut-name=難波徳郎 kn-aut-sei=難波 kn-aut-mei=徳郎 aut-affil-num=3 ORCID= en-aut-name=TakadaJun en-aut-sei=Takada en-aut-mei=Jun kn-aut-name=高田潤 kn-aut-sei=高田 kn-aut-mei=潤 aut-affil-num=4 ORCID= en-aut-name=MiuraYoshinari en-aut-sei=Miura en-aut-mei=Yoshinari kn-aut-name=三浦嘉也 kn-aut-sei=三浦 kn-aut-mei=嘉也 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=(堤)松下電器産業株式会社 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=岡山大学 en-keyword=ZnO film kn-keyword=ZnO film en-keyword=Al doped ZnO kn-keyword=Al doped ZnO en-keyword=transparent conductive film kn-keyword=transparent conductive film en-keyword=r.f. activated reactive evaporation method kn-keyword=r.f. activated reactive evaporation method END start-ver=1.4 cd-journal=joma no-vol=3 cd-vols= no-issue=1 article-no= start-page=145 end-page=156 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980114 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Consideration for the correlation between basicity of oxide glasses and chemical shift of O1s binding energy in XPS kn-title=酸化物ガラスの塩基度とXPSによるO1ｓ束縛エネルギーの化学シフトの相関に関する考察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Binding energy of O1s core electron measured in XPS is a candidate to determine new scale of Lewis basicity of oxide ion in glass. Some mathematical expressions for the basicity or XPS chemical shift, such as charge parameter and optical basicity, are compared with experimental O1s binding energy in binary alkali oxide glasses. The expressions so far in use need some modification in parameters. A new empirical expression introduced in this paper gives new concept and universal scale of basicity. en-copyright= kn-copyright= en-aut-name=NanbaTokuro en-aut-sei=Nanba en-aut-mei=Tokuro kn-aut-name=難波徳郎 kn-aut-sei=難波 kn-aut-mei=徳郎 aut-affil-num=1 ORCID= en-aut-name=MiuraYoshinari en-aut-sei=Miura en-aut-mei=Yoshinari kn-aut-name=三浦嘉也 kn-aut-sei=三浦 kn-aut-mei=嘉也 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=1 article-no= start-page=119 end-page=125 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020322 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Upconversion property and light scattering in Tm(3+)-doped glass-ceramics kn-title=Tm(3+)含有結晶化ガラスのアップコンバージョン特性と光散乱 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Glass-ceramics containing Pb(x)Cd(1-x)F(2) microcrystallites were prepared through heat treatment of Tm(3+)/Yb(3+)doped SiO(2)-Al(2)O(3)-PbF(2) glasses. The crystallite size was controlled by varying the heat-treatment time. By changing glass composition, two types of strong optical scattering, Rayleigh and Mie scattering modes were observed for the glass ceramics. In the case of Rayleigh scattering, the scattering region expanded to the long-wavelength side with increasing the heat-treatment time. On the other hand, in the case of Mie scattering, the region were hardly dependent on wavelength, and visible light was widely scattered. It was argued that the different scattering phenomena were caused by the different size of the crystallites or their morphogical texture. Furthermore, the glass-ceramics with strong optical scattering showed higher upconversion fluorescence intensity than the matrix glass. The mechanisms for the enhanced upconversion due to the scattering were discussed. en-copyright= kn-copyright= en-aut-name=MiuraYoshinari en-aut-sei=Miura en-aut-mei=Yoshinari kn-aut-name=三浦嘉也 kn-aut-sei=三浦 kn-aut-mei=嘉也 aut-affil-num=1 ORCID= en-aut-name=DingYong en-aut-sei=Ding en-aut-mei=Yong kn-aut-name=丁勇 kn-aut-sei=丁 kn-aut-mei=勇 aut-affil-num=2 ORCID= en-aut-name=MurataTakashi en-aut-sei=Murata en-aut-mei=Takashi kn-aut-name=村田隆 kn-aut-sei=村田 kn-aut-mei=隆 aut-affil-num=3 ORCID= en-aut-name=HimeiYusuke en-aut-sei=Himei en-aut-mei=Yusuke kn-aut-name=姫井裕助 kn-aut-sei=姫井 kn-aut-mei=裕助 aut-affil-num=4 ORCID= en-aut-name=NanbaTokuro en-aut-sei=Nanba en-aut-mei=Tokuro kn-aut-name=難波徳郎 kn-aut-sei=難波 kn-aut-mei=徳郎 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=岡山大学 en-keyword=Optical scattering kn-keyword=Optical scattering en-keyword=Glass-ceramics kn-keyword=Glass-ceramics en-keyword=Oxyfluoride glass kn-keyword=Oxyfluoride glass en-keyword=Microcrystallite kn-keyword=Microcrystallite en-keyword=Upconversion fluorescence kn-keyword=Upconversion fluorescence END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=1 article-no= start-page=113 end-page=118 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020322 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of ultrasonic treatment on the preparation of transparent glass-ceramic phosphor kn-title=長残光性透明ガラスセラミックスの作製における超音波前処理効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effects of ultrasonic surface treatment (UST) on the crystallization behavior and optical emission properties were investigated for the transparent glass-ceramics prepared from calcium aluminosilicate glasses co-doped with Eu(2+), Nd(3+). The glass-ceramics A were prepared by sintering a glass 45CaO・45Al(2)O(3)・10SiO(2) (mol%) containing 0.5Eu(2)O(3)+1Nd(2)O(3) under a 2% H(2)+98% Ar reducing atmosphere. In the glass-ceramics A, three crystalline phases, CaAl(2)O(4) (CA), CaAl(4)O(7) (CA2) and Ca(2)Al(2)SiO(7) (CAS) were commonly confirmed by X-ray diffraction. No drastic change in the amount of the precipitated crystalline phases was observed even in the case using UST of CA powders. It was suggested that the optical emission properties of the glass-ceramics A was responsible for the CA2 crystals. The glass-ceramics B were also prepared from a 51CaO・42Al(2)O(3)・7SiO(2) glass. The CA crystals were separately precipitated in the glass-ceramics B. In particular, a large amount of CA was successfully produced by stirring the UST suspension to prevent the sedimentation of the UST particles. The glass-ceramic B so-prepared showed strong photoluminescence but weak phosphorescence compared with other glass-ceramics B, indicating that the photoluminescence and phosphorescence were originated in different electron-trapping levels. The amount of the trap levels associated with the long lasting phosphorescence, such as oxygen vacancies, was probably small in the glass-ceramic B prepared with the stirring UST. en-copyright= kn-copyright= en-aut-name=InoueTeruhide en-aut-sei=Inoue en-aut-mei=Teruhide kn-aut-name=井上輝英 kn-aut-sei=井上 kn-aut-mei=輝英 aut-affil-num=1 ORCID= en-aut-name=NakashimaMizuho en-aut-sei=Nakashima en-aut-mei=Mizuho kn-aut-name=中島瑞穂 kn-aut-sei=中島 kn-aut-mei=瑞穂 aut-affil-num=2 ORCID= en-aut-name=NanbaTokuro en-aut-sei=Nanba en-aut-mei=Tokuro kn-aut-name=難波徳郎 kn-aut-sei=難波 kn-aut-mei=徳郎 aut-affil-num=3 ORCID= en-aut-name=MiuraYoshinari en-aut-sei=Miura en-aut-mei=Yoshinari kn-aut-name=三浦嘉也 kn-aut-sei=三浦 kn-aut-mei=嘉也 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 en-keyword=ultrasonic surface treatment (UST) kn-keyword=ultrasonic surface treatment (UST) en-keyword=surface crystallization kn-keyword=surface crystallization en-keyword=glass-ceramics kn-keyword=glass-ceramics en-keyword=long lasting phosphorescence kn-keyword=long lasting phosphorescence en-keyword=calcium aluminosilicate glass kn-keyword=calcium aluminosilicate glass END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=1 article-no= start-page=55 end-page=74 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020322 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Damage factors analysis for small embankment dams due to the Hyogoken-Nambu earthquake special to Hokudan Town kn-title=兵庫県南部地震による北淡町を中心にしたため池の被害の要因分析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study was performed to clarify which factors affected damage to take-ike (small embankment dams for irrigation in Japanese) of Hokudan Town on Awaji Island in western Japan due to Hyogoken-Nambu earthquake. Multivariate and ordinary statistical analysis were carried out using documentary data (181 damaged and 328 undamaged dams), and ordinary one was done for the results investigated in situ. The model for the multivariate analysis was created with 13 items and 94 categories for 4 groups (Location, Geology Structure, and History of Dam). As a result, the factors causing to damage for dam are (1) the nearest fault (Nojima, Mizukoshi and D2), (2) embankment volume (the larger the more), (3) angle of crest axis to epicenter (diagonal and normal), (4) distance to the nearest fault (less than 500 m), (5) distance to the epicenter (8 to 14 km which almost agree to the location of seismic intensity 7 JMA), (6) play view of dam axis (3 or 4 axes), (7) angle of crest axis to nearest fault (diagonal and normal), (8) elevation of dam site (over 100 m), (9) surface geology of dam site (non-cohesive soil), (10) era of construction (prior to 1891), and (11) soil properties of embankment (constructed of sand, smaller penetration resistance). en-copyright= kn-copyright= en-aut-name=FujiiHiroaki en-aut-sei=Fujii en-aut-mei=Hiroaki kn-aut-name=藤井弘章 kn-aut-sei=藤井 kn-aut-mei=弘章 aut-affil-num=1 ORCID= en-aut-name=KunimasaKana en-aut-sei=Kunimasa en-aut-mei=Kana kn-aut-name=国政華奈 kn-aut-sei=国政 kn-aut-mei=華奈 aut-affil-num=2 ORCID= en-aut-name=NanbaAkiyo en-aut-sei=Nanba en-aut-mei=Akiyo kn-aut-name=難波明代 kn-aut-sei=難波 kn-aut-mei=明代 aut-affil-num=3 ORCID= en-aut-name=YokomizoTakayuki en-aut-sei=Yokomizo en-aut-mei=Takayuki kn-aut-name=横溝隆之 kn-aut-sei=横溝 kn-aut-mei=隆之 aut-affil-num=4 ORCID= en-aut-name=NishimuraShin-ichi en-aut-sei=Nishimura en-aut-mei=Shin-ichi kn-aut-name=西村伸一 kn-aut-sei=西村 kn-aut-mei=伸一 aut-affil-num=5 ORCID= en-aut-name=ShimadaKiyoshi en-aut-sei=Shimada en-aut-mei=Kiyoshi kn-aut-name=島田清 kn-aut-sei=島田 kn-aut-mei=清 aut-affil-num=6 ORCID= en-aut-name=HoriToshio en-aut-sei=Hori en-aut-mei=Toshio kn-aut-name=堀俊男 kn-aut-sei=堀 kn-aut-mei=俊男 aut-affil-num=7 ORCID= en-aut-name=NishiyamaTatsuro en-aut-sei=Nishiyama en-aut-mei=Tatsuro kn-aut-name=西山竜朗 kn-aut-sei=西山 kn-aut-mei=竜朗 aut-affil-num=8 ORCID= en-aut-name=WakitaniYoshiaki en-aut-sei=Wakitani en-aut-mei=Yoshiaki kn-aut-name=脇谷芳招 kn-aut-sei=脇谷 kn-aut-mei=芳招 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=岡山大学 affil-num=6 en-affil= kn-affil=元岡山大学環境理工学部環境管理工学科(現東京農工大学) affil-num=7 en-affil= kn-affil=(株)ウエスコ affil-num=8 en-affil= kn-affil=岡山大学 affil-num=9 en-affil= kn-affil=岡山大学 en-keyword=Earth dam kn-keyword=Earth dam en-keyword=earthquake damage kn-keyword=earthquake damage en-keyword=site investigation kn-keyword=site investigation en-keyword=statistical analysis kn-keyword=statistical analysis en-keyword=case study kn-keyword=case study END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=1 article-no= start-page=153 end-page=162 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of Surface State of Ceramic Particles Suspended in Aqueous Solution by Potentiometric Titration Method kn-title=電位差適定によるセラミック粉体の表面電位の測定 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Surface states of ceramic particles such as SiO(2), Al(2)O(3), Si(3)N(4) and so on suspended in aqueous alkaline solutions were successfully and easily determined by a potentiometric titration method. Isoelctric point, iep and excess surface charge density were classified and evaluated for many ceramic particles from the view points of aggregation and dispersion of particles and solubility in aqueous solution. en-copyright= kn-copyright= en-aut-name=MiuraYoshinari en-aut-sei=Miura en-aut-mei=Yoshinari kn-aut-name=三浦嘉也 kn-aut-sei=三浦 kn-aut-mei=嘉也 aut-affil-num=1 ORCID= en-aut-name=NanbaTokuro en-aut-sei=Nanba en-aut-mei=Tokuro kn-aut-name=難波徳郎 kn-aut-sei=難波 kn-aut-mei=徳郎 aut-affil-num=2 ORCID= en-aut-name=ShinodaMasakatsu en-aut-sei=Shinoda en-aut-mei=Masakatsu kn-aut-name=篠田真克 kn-aut-sei=篠田 kn-aut-mei=真克 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 en-keyword=potentiometric titration method kn-keyword=potentiometric titration method en-keyword=isoelctric point kn-keyword=isoelctric point en-keyword=excess surface charge density kn-keyword=excess surface charge density en-keyword=ceramic particle kn-keyword=ceramic particle en-keyword=suspension kn-keyword=suspension en-keyword=aqueous solution kn-keyword=aqueous solution END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue=1 article-no= start-page=161 end-page=165 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Material Recycling of Municipal Waste Slags by Using Phase Separation of Glass kn-title=ガラスの相分離を利用した都市ゴミ溶融スラグのマテリアルリサイクル en-subtitle= kn-subtitle= en-abstract= kn-abstract=A novel recycling process of municipal waste slags obtaining Fe-free colorless materials was developed by using a phase separation of borosilicate glass. B(2)O(3) was added to a simulated waste slag to promote the phase separation. The slag glasses were heat-treated above glass transition temperatures, from which phase separation was successfully induced. The phase-separated slag glasses were still colored in black due to Fe ions, and after soaking in acid, they were successfully bleached, obtaining colorless solids. According to compositional analyses, no Fe ions were confirmed in the remaining insolubles, indicating that Fe ions were preferentially incorporated into the borate-rich phases soluble in acid. The main constituent of the colorless solids was SiO(2) and the end products obtained in the present process were expected as an alternative of pure silica glass. en-copyright= kn-copyright= en-aut-name=ImaokaTakuya en-aut-sei=Imaoka en-aut-mei=Takuya kn-aut-name=今岡卓也 kn-aut-sei=今岡 kn-aut-mei=卓也 aut-affil-num=1 ORCID= en-aut-name=SakidaShinichi en-aut-sei=Sakida en-aut-mei=Shinichi kn-aut-name=崎田真一 kn-aut-sei=崎田 kn-aut-mei=真一 aut-affil-num=2 ORCID= en-aut-name=NanbaTokuro en-aut-sei=Nanba en-aut-mei=Tokuro kn-aut-name=難波徳郎 kn-aut-sei=難波 kn-aut-mei=徳郎 aut-affil-num=3 ORCID= en-aut-name=MiuraYoshinari en-aut-sei=Miura en-aut-mei=Yoshinari kn-aut-name=三浦嘉也 kn-aut-sei=三浦 kn-aut-mei=嘉也 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 en-keyword=slag kn-keyword=slag en-keyword=recycling kn-keyword=recycling en-keyword=colorless glass kn-keyword=colorless glass en-keyword=phase separation kn-keyword=phase separation END start-ver=1.4 cd-journal=joma no-vol=85 cd-vols= no-issue=1 article-no= start-page=115 end-page=117 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of Alternating Magnetic Field on Plant Growth kn-title=変動磁場の植物生長に及ぼす影響 en-subtitle= kn-subtitle= en-abstract=戦後日本の農業は、農業機械の導入と化学薬品の投入により飛躍的にその生産性を高めてきた。今や、米の単位面積当たりの収量は世界有数であるといえる。しかしながら、多量のエネルギを圃場に投入し続けてきたことによるひずみは、農業生産の場のあちこちに現れてきており、環境問題の観点からも早急な対策を講じる必要がある。そこでまず検討すべき点は、現在の収量を維持しつつ、いかにして圃場への投入エネルギ量を低減していくかということである。そのため数々の手法が研究されているが、著者が注目しているのは微少エネルギの有効利用である。磁場を含む微少な環境因子の植物の生長に与える影響は、活発な論議がなされている。光、温度、水、栄養や大気環境等の環境因子と植物生長の相関についてに比べ、研究テーマとしてはそれほど大きく取り上げられてはこなかった。一方、篤農家を始めとする現場においては、例えば植物栽培に音楽を取り入れて生長促進を図るなど、微少環境の効果が決して小さくないことが実証されている。著者の現在までの研究でも、磁場等微少環境が植物の生長に対して何らかの影響を及ぼすことが確かめられており、これを定量化していくことがこれからの課題となっている。微少エネルギを植物の栽培に適応していくメリットとしては、安全かつ安価に植物の生長をコントロールできることがあげられる。現在の農業は大量のエネルギを植物に提供することで、増収や生長促進などの効果をあげてきた。確かに、作れば売れた時代はそれでもよかった。しかし、供給が需要を上回り、農家そのものが自由競争の原理の中での生き残りを迫られている今、新たな視点に立った農業生産方法の確立が必要とされている。高すぎる生産コストは市場での競争に不利であるし、化学薬品を大量に投入しての農産物は社会的に敬遠されつつある。ただし、値段が高いにも関わらず有機農法が社会的に支持を受けているのは、安全性を消費者がより重要視していると考えてよいだろう。したがって、微少エネルギの農業への導入は人に環境に優しいことを目指す、これからの農業大系に不可欠であるといえる。 kn-abstract=This paper describes the effect of alternating magnetic fields on plant germination. Experiments were conducted utilizing various frequencies and two states of polarity.Electromagnetic coils were used to generate the fields and 'Komatsuna' plants were chosen as subjects. The frequency was varied from 1 to 1000 Hz,at a fixed intensity of 5 Gauss. The magnetic polarity was controlled by reversing the current direction. Measured parameter was the germination rate. The results indicated that magnetic fields do influence plant germination, and that frequency of the fields is a more important factor in germination rates than polarity. Maximum germination rates,which were 20% higher than control rates,were obtained at around 10 Hz. en-copyright= kn-copyright= en-aut-name=NambaKazuhiko en-aut-sei=Namba en-aut-mei=Kazuhiko kn-aut-name=難波和彦 kn-aut-sei=難波 kn-aut-mei=和彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=magnetic stimulation kn-keyword=magnetic stimulation en-keyword=frequency kn-keyword=frequency en-keyword=germination kn-keyword=germination en-keyword=alternating magnetic field kn-keyword=alternating magnetic field END start-ver=1.4 cd-journal=joma no-vol=84 cd-vols= no-issue=1 article-no= start-page=17 end-page=23 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=19950201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ethephon-induced Bisexual Flowers on Primary Shoot and Subsequent Fruit Quality of Melon,cv. Honey Dew kn-title=メロン‘ハネデュー’の主枝節上における両性花の発現及び着生果実の形質に及ぼすエセフォンの影響 en-subtitle= kn-subtitle= en-abstract='ハネデュー’メロンの花の性表現及び着生果実の形質に対するエセフォン処理の影響を検討した。第8葉期にエセフォン100,200mg･ℓ-1濃度で葉面散布すると、主枝節に雌花が多く誘導されたが、200mg･ℓ-1処理区では同時に花蕾不発育節や落蕾も増加した。また、節間の短縮による茎長の抑制が認められた。適濃度と考えられるエセフォン100mg･ℓ-1濃度で反復処理した場合、雌花数、雄花数ともに著しく減少した。第2葉、第4葉、第8葉期に100mg･ℓ-1 濃度で処理した場合、主枝節上の雌花誘導節位はそれぞれ6～9節、11～22節、16～25節で、処理時の生育ステージが早い段階ほど雌花発現に要する節数は少なくなった。エセフォン処理区の主枝節着生果実は無処理区の側枝節着生果実より縦長で、糖度は若干低く、軟化が進んでいた。以上の結果から、エセフォン処理により主枝15～20節に雌花を誘導するには、第4～6葉期に100mg･ℓ-1 の濃度で散布するのが最も効果的であることが示唆された。 kn-abstract=The effects of ethephon on the sex expression of flowers,and subsequent fruit quality of 'Honey Dew'melon were investigated.Ethphon induced many bisexual flowers on the primary shoot in the concentration of 100 or 200mg･ℓ-1 applied at the 8true-leaf expanded stage.The concentration of 200mg･ℓ-1 caused undeveloped and aborted flower buds,and the plant hight decreased with shoter internode.When enthphon treatment was repeated in the concentration of 100mg･ℓ-1,the number of bisexual flowers decreased;replicated treatment reduced both bisexual and flowers.In plants treated with 100mg･ℓ-1 at the 2,4 or 8 true-leaf expanded stages,many bisexual flowers occurred at the 6th to 9th,11th to 22nd and 16th to 25th nodes of the primary shoot,respectively.The fruits set on the primary shoot by ethephon treatment increased in the ratio of longitudinal diameter to cross.Ethephon-induced fruits decreased slightly in sugar content and the flesh was softer than those of the control.These results suggested that single treatment of ethephon was recommended in the concentration of 100mg･ℓ-1 at the 4-6 true-leaf expanded stage for induction of bisexual flowers on the 15th to 20th nodes of the primary shoot. en-copyright= kn-copyright= en-aut-name=IkedaYasumasa en-aut-sei=Ikeda en-aut-mei=Yasumasa kn-aut-name=池田康政 kn-aut-sei=池田 kn-aut-mei=康政 aut-affil-num=1 ORCID= en-aut-name=NanbaSyoji en-aut-sei=Nanba en-aut-mei=Syoji kn-aut-name=難波昌二 kn-aut-sei=難波 kn-aut-mei=昌二 aut-affil-num=2 ORCID= en-aut-name=MasudaMasaharu en-aut-sei=Masuda en-aut-mei=Masaharu kn-aut-name=桝田正治 kn-aut-sei=桝田 kn-aut-mei=正治 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 en-keyword=melon kn-keyword=melon en-keyword=ethephon kn-keyword=ethephon en-keyword=sex expression kn-keyword=sex expression en-keyword=fruit quality kn-keyword=fruit quality END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=1 article-no= start-page=187 end-page=193 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=岡山とギザにおける太陽エネルギーの所要量と推定 kn-title=Solar Energy Required and Predicted in Okayama and Giza (Egypt) en-subtitle= kn-subtitle= en-abstract=太陽エネルギーを農業に有効利用する目的で、岡山とエジプト・ギザを観測地点として、獲得できるエネルギーの量を観測し、2地点での比較を行った。岡山とギザでは緯度が、34°39'と30°02'と異なるために集めることができる太陽エネルギーの量に差が生じ、その量はギザの方が多くなり農業への有効利用の可能性が大である。 kn-abstract=Egypt as a developed country still has no electricity in many villages but at the same time has enough natural energy such as solar energy. Solar radiation data is not always available in many areas of the world and they have to be estimated using some sort of empirical model. The results of this prediction are compared for the measured data of two different countries: Japan (Okayama City) and Egypt (Giza City). The comparison shows an acceptable level of prediction between both of them. On a June day, actual accumulated insolation through one day was 18.88 MJ/m2 in Okayama and 22.79 MJ/m2 in Giza. On the other hand on a January day, actual accumulated insolation through one day was 4.93 MJ/m2 in Okayama and 5.49 MJ/m2 in Giza. We can see also that in January the worst solar month, solar water heaters still provide 35.25% of the energy for Okayama and 40.37% for Giza, That was because in Okayama the number of sunny days was only 6 but there were 19 in Giza. en-copyright= kn-copyright= en-aut-name=ElbatawiIbrahim E. A. en-aut-sei=Elbatawi en-aut-mei=Ibrahim E. A. kn-aut-name=エルバタウィイブラヒム エルサエド アハメド kn-aut-sei=エルバタウィ kn-aut-mei=イブラヒム エルサエド アハメド aut-affil-num=1 ORCID= en-aut-name=MohriKentaro en-aut-sei=Mohri en-aut-mei=Kentaro kn-aut-name=毛利建太郎 kn-aut-sei=毛利 kn-aut-mei=建太郎 aut-affil-num=2 ORCID= en-aut-name=NambaKazuhiko en-aut-sei=Namba en-aut-mei=Kazuhiko kn-aut-name=難波和彦 kn-aut-sei=難波 kn-aut-mei=和彦 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 en-keyword=solar energy kn-keyword=solar energy en-keyword=solar radiation kn-keyword=solar radiation en-keyword=energy collected kn-keyword=energy collected en-keyword=simutation kn-keyword=simutation END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=1 article-no= start-page=181 end-page=186 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=複雑度により王林リンゴの損傷判別 kn-title=Bruise Detection Using Complexity for Oorin Apples en-subtitle= kn-subtitle= en-abstract=本研究は、王林リンゴのgreen画像を2値化し、その2値化画像を分析した。損傷果を検出するために、2値化画像の面積の変換による、画像の複雑性をもとに、正常部及び損傷部(損傷部は画像の真ん中辺り、エッジ辺り、真ん中とエッジ辺りとも)の画像を分析した。この画像種類複雑性の分析結果によって、多しきい値方法を使用して、正常部と損傷部は85.7% の精度で判断できだ。 kn-abstract=The complexity of binary image for apples as normal, bruised around centerbruised around edge, and bruised around both edge and center were analyzed. Amulti-threshold method (thresholds determined by area rates 0.3,0.4,...0.7 for complexity rates analysis) was used successfully for bruise classification. Leaving out apples with bruising around the edge, apples were classified 85.7% correctly. en-copyright= kn-copyright= en-aut-name=ChenYong Bo en-aut-sei=Chen en-aut-mei=Yong Bo kn-aut-name=陳永波 kn-aut-sei=陳 kn-aut-mei=永波 aut-affil-num=1 ORCID= en-aut-name=MohriKentaro en-aut-sei=Mohri en-aut-mei=Kentaro kn-aut-name=毛利建太郎 kn-aut-sei=毛利 kn-aut-mei=建太郎 aut-affil-num=2 ORCID= en-aut-name=NambaKazuhiko en-aut-sei=Namba en-aut-mei=Kazuhiko kn-aut-name=難波和彦 kn-aut-sei=難波 kn-aut-mei=和彦 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 en-keyword=Oorin apple kn-keyword=Oorin apple en-keyword=bruise kn-keyword=bruise en-keyword=image processing kn-keyword=image processing END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=1 article-no= start-page=175 end-page=180 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Heat Transfer in Agricultural Products by Far-infrared Ray kn-title=遠赤外線による農産物の熱伝達に関する研究 en-subtitle= kn-subtitle= en-abstract=農産物の乾燥は、産物の変質防止、貯蔵性や加工性の向上を目的として行われる。また、農産物は形状や物性が異なっており、独性な風味をもっているものが多く、その品質を重視する乾燥方法が取られなければならず、乾燥する上で種々の制約があり、それぞれの農産物に対して乾燥方法が研究されて乾燥機は独自の構造をもったものが発達している。農産物を対象にする従来からの乾燥システムは熱の利用上から分ければ、熱風乾燥、補助熱源付加通風乾燥および常温通風乾燥などのタイプが考えられる。熱を利用する乾燥は加熱された空気の中に被乾燥物を置き、対流熱伝達によって加熱し乾燥させるもので、通称は熱風乾燥という。その目的は乾燥時間を短縮させ、乾燥能率を向上することであり、もっとも一般的な乾燥方法である。従来の加熱乾燥は、被乾燥物の表面を加熱し、表面から内部への熱伝達は、被乾燥物自身の熱伝導により物体の表面から内部に熱が伝えられ、加熱されて水分を蒸発させるものである。しかし、多数の農産物は熱伝導率が小さいので、内部温度を上昇させるには、表面の温度を高くして表面と内部との温度こう配を大きくしなければならない。そのためには熱風の温度を高くし、加熱時間を長くする必要がある。温度こう配が大きいほど加熱速度は大きくなるが、乾燥過程において焦げる。煮えるなど品質に悪影響も生ずる。ここで、遠赤外線加熱の特徴を利用した農産物の高能率乾燥技術を確立するために、蒸したサツマイモを供試して加熱するとき、熱伝達の様子を熱流束および熱拡散率（温度伝達率）を用いて、熱風による加熱と比較しながら表面から近い部分の熱伝達について検討した。 kn-abstract=Heat is transferred when the objected has temperature differences. In this research, the difference of two heating methods (far-infrared ray heating and hot wind heating) was analyzed. To compare their differences, the heat flux was measured by setting a heat flux meter beneath the surface of the object at different depths, then the heat conductivities and heat diffusion rates were analyzed. 1. Compared with hot wind, far-infrared ray heating has more heat flux before reaching a definite depth. 2. The heat conductivity and heat diffusion ratesby hot wind heating have specific properties with special objects. The heat conductivity and heat diffusion rate of far-infrared heating are higher than those of hot wind heating. The differences are considered to be caused by far-infrared rays. en-copyright= kn-copyright= en-aut-name=LiuHouqing en-aut-sei=Liu en-aut-mei=Houqing kn-aut-name=劉厚清 kn-aut-sei=劉 kn-aut-mei=厚清 aut-affil-num=1 ORCID= en-aut-name=MohriKentaro en-aut-sei=Mohri en-aut-mei=Kentaro kn-aut-name=毛利建太郎 kn-aut-sei=毛利 kn-aut-mei=建太郎 aut-affil-num=2 ORCID= en-aut-name=NambaKazuhiko en-aut-sei=Namba en-aut-mei=Kazuhiko kn-aut-name=難波和彦 kn-aut-sei=難波 kn-aut-mei=和彦 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 en-keyword=heat flux kn-keyword=heat flux en-keyword=thermal diffusion rate kn-keyword=thermal diffusion rate en-keyword=far-infrared ray kn-keyword=far-infrared ray en-keyword=heat properth of object kn-keyword=heat properth of object END start-ver=1.4 cd-journal=joma no-vol=92 cd-vols= no-issue=1 article-no= start-page=57 end-page=61 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=200302 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Terminal Velocity of Fluidizing Grains in a Vertical Pipe kn-title=鉛直管内穀粒流動化の終端速度 en-subtitle= kn-subtitle= en-abstract=穀粒を輸送し，調製加工する場合には，その特性を知る必要がある．本研究は，鉛直管内における流動状態を調べることにより，穀粒の基本的流動特性を明らかにする目的で，玄米，BB弾，大豆を空気流によって流動化させて，流動化開始風速と終端速度を求め，その流動状態をビデオカメラで記録して観察した．その結果から：1.流動化開始風速は，大豆が1.6～2.1m/ｓ，BB弾は1.2～1.7m/ｓ，玄米は0.6～1.1m/ｓの範囲にあった．2.玄米に噴水状態が現れたが，大豆とBB弾に噴水状態がなかった．これはBB弾と大豆の形状が球あるいは球に近いためであると考えられた．3.終端速度を測定した結果，玄米が6.8m/ｓ，BB弾は9.5m/ｓで，大豆は12.2m/ｓであることが分かった kn-abstract=It is necessary to know the characteristics of grain when grain is transferred and processed. In this research, in order to clarify the fundamental flow characteristics of grain, the flow state in a vertical pipe was investigated. Brown rice, BB shot (pellets) "BB's" and soybean were fluidized by the air style. We determined minimum fluidization velocity and terminal velocity, recorded the flow state, and observed the flow state with a video camera. The results of the experiment were as follows: 1) Minimum fluidization wind velocities were 1.6-2.1m/s in soybean, and 1.2-1.7m/s in BB's. This might be because of the shapes of soybean and BB's. 2)A fountain state appeared in brown rice, but not in either soybean or BB's. This might be because of the shapes of soybean and BB's. 3)Terminal velocity was 6.8m/s in brown rice, 9.5m/s in BB's, and 12.2m/s in soybean respectively. en-copyright= kn-copyright= en-aut-name=TaNa en-aut-sei=Ta en-aut-mei=Na kn-aut-name=塔娜 kn-aut-sei=塔 kn-aut-mei=娜 aut-affil-num=1 ORCID= en-aut-name=MohriKentaro en-aut-sei=Mohri en-aut-mei=Kentaro kn-aut-name=毛利健太郎 kn-aut-sei=毛利 kn-aut-mei=健太郎 aut-affil-num=2 ORCID= en-aut-name=NambaKazuhiko en-aut-sei=Namba en-aut-mei=Kazuhiko kn-aut-name=難波和彦 kn-aut-sei=難波 kn-aut-mei=和彦 aut-affil-num=3 ORCID= en-aut-name=MontaMitsuji en-aut-sei=Monta en-aut-mei=Mitsuji kn-aut-name=門田充司 kn-aut-sei=門田 kn-aut-mei=充司 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 en-keyword=grain kn-keyword=grain en-keyword=minimum fluidization velocity kn-keyword=minimum fluidization velocity en-keyword=static pressure drop kn-keyword=static pressure drop en-keyword=terminal velocity kn-keyword=terminal velocity END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=き裂開口変位分布計測に基づく残留応力場の疲労き裂伝ぱ挙動の評価 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NanbaKoichi en-aut-sei=Nanba en-aut-mei=Koichi kn-aut-name=難波浩一 kn-aut-sei=難波 kn-aut-mei=浩一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=インターフェロン抵抗性を示すC型肝炎ウィルス レプリコン細胞の樹立 kn-title=Establishment of hepatitis C virus replicon cell lines possessing interferon-resistant phenofield name="type" en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NambaKatsuyuki en-aut-sei=Namba en-aut-mei=Katsuyuki kn-aut-name=難波克行 kn-aut-sei=難波 kn-aut-mei=克行 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=19920328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=東アジア産トウダイグサ科植物に含まれる新種加水分解性タンニンオリゴマーの化学構造 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=難波治 kn-aut-sei=難波 kn-aut-mei=治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=高速信号伝送系のEMC制御およびEMI低減のための理論モデル kn-title=Theoretical Modeling for EMC Control and EMI Reduction of High Speed Signaling Systems en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=難波明博 kn-aut-sei=難波 kn-aut-mei=明博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=中年期の日本人女性の生き方と成熟過程に関する研究 -結婚･夫婦関係を中心として- en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=難波淳子 kn-aut-sei=難波 kn-aut-mei=淳子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=変形性膝関節症軟骨におけるオステオネクチンの出現について kn-title=Immunohistochemical expression of osteonectin in articular cartilage from osteoarthritic knees en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=難波良文 kn-aut-sei=難波 kn-aut-mei=良文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1962 dt-pub=19620331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=大腸内容輸送に対する腸内粘膜反射の役割について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=難波良司 kn-aut-sei=難波 kn-aut-mei=良司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=色素レーザーによる単純性血管腫の治療:644例の検討 kn-title=The treatment of port-wine stains by the dye laser: A study of 644 patients en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=難波祐三郎 kn-aut-sei=難波 kn-aut-mei=祐三郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=19940331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=肺癌患者におけるHTLV-I 感染と間質性肺病変に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=難波靖治 kn-aut-sei=難波 kn-aut-mei=靖治 aut-affil-num=1 ORCID= affil-num=1 en-affil= 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