start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=6 article-no= start-page=619 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250313 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of Trehalose on Halitosis: A Randomized Cross-Over Clinical Trial en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background/Objectives: Halitosis is a condition characterized by an unpleasant malodor. Intra-oral halitosis is caused by volatile sulfur compounds (VSCs) and can be associated with oral dryness. Trehalose is one of the materials used to relieve oral dryness. The aim of the present study was to investigate the effect of trehalose on halitosis. Methods: This prospective, double-blinded, placebo-controlled, cross-over study enrolled volunteers from Okayama University Hospital. The participants were randomly divided into two groups, with one group receiving trehalose (a 10% trehalose solution) and the other receiving a placebo (distilled water) in a 1:1 allocation. The primary study outcome was the subjective organoleptic test. The secondary outcomes were the concentrations of the VSCs, which were measured using a portable gas chromatography device, and the oral moisture status, which was measured using an oral moisture meter. The planned sample size was 10 participants based on the previous study. Results: The final intention-to-treat analysis was performed using the data from 9 participants. After applying 10% trehalose as an oral spray, the organoleptic score decreased in a time-dependent manner. However, no significant differences were seen between the trehalose and placebo groups. In terms of secondary outcomes, the oral moisture levels increased immediately after the trehalose spray application, and significant differences in the amount of change from the baseline were seen between the trehalose and placebo groups (p = 0.047). No significant differences were seen in any of the other variables (p > 0.05). Conclusions: We could not identify any positive effects on halitosis from a one-time 10% trehalose application as an oral spray in this prospective, double-blinded, placebo-controlled, cross-over study. However, the trehalose application immediately improved the oral moisture levels and was useful for treating oral dryness. en-copyright= kn-copyright= en-aut-name=MiyaiHisataka en-aut-sei=Miyai en-aut-mei=Hisataka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TomofujiTakaaki en-aut-sei=Tomofuji en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MizunoHirofumi en-aut-sei=Mizuno en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoritaManabu en-aut-sei=Morita en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakaharaMomoko en-aut-sei=Nakahara en-aut-mei=Momoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KataokaKota en-aut-sei=Kataoka en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SumitaIchiro en-aut-sei=Sumita en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=UchidaYurika en-aut-sei=Uchida en-aut-mei=Yurika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ToyamaNaoki en-aut-sei=Toyama en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YokoiAya en-aut-sei=Yokoi en-aut-mei=Aya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=Yamanaka-KohnoReiko en-aut-sei=Yamanaka-Kohno en-aut-mei=Reiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=TakeuchiNoriko en-aut-sei=Takeuchi en-aut-mei=Noriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=MaruyamaTakayuki en-aut-sei=Maruyama en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=EkuniDaisuke en-aut-sei=Ekuni en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Community Oral Health, School of Dentistry, Asahi University kn-affil= affil-num=3 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Oral Health Sciences, Faculty of Health Care Sciences, Takarazuka University of Medical and Health Care kn-affil= affil-num=5 en-affil=Department of Preventive Dentistry, Division of Dentistry, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Preventive Dentistry, Division of Dentistry, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Preventive Dentistry, Division of Dentistry, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Preventive Dentistry, Division of Dentistry, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Preventive Dentistry, Division of Dentistry, Okayama University Hospital kn-affil= affil-num=12 en-affil=Department of Preventive Dentistry, Division of Dentistry, Okayama University Hospital kn-affil= affil-num=13 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=14 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=halitosis kn-keyword=halitosis en-keyword=trehalose kn-keyword=trehalose en-keyword=oral dryness kn-keyword=oral dryness en-keyword=cross-over study kn-keyword=cross-over study en-keyword=randomized trial kn-keyword=randomized trial END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=65 end-page=81 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Regional Response to Securing Transportation through Mutual Assistance ―A Case Study of Okayama Prefecture― kn-title=共助による交通手段の確保に係る地域的対応 ―岡山県内を例に― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KATAOKAKatsumi en-aut-sei=KATAOKA en-aut-mei=Katsumi kn-aut-name=片岡克巳 kn-aut-sei=片岡 kn-aut-mei=克巳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院社会文化科学研究科 END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=8366 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250311 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Local-structure insight into the improved superconducting properties of Pb-substituted La(O, F)BiS2: a photoelectron holography study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Pb-substituted La(O, F)BiS2 (Pb-LaOFBiS2) exhibits improved superconducting properties and a resistivity anomaly around 100 K that is attributed to a structural transition. We have performed temperature(T)-dependent photoelectron holography (PEH) to study dopant incorporation sites and the local structure change across the anomaly. The PEH study of Pb-LaOFBiS2 provided evidence for the dominant incorporation sites of Pb and F: Pb atoms are incorporated into the Bi sites and F atoms are incorporated into the O site. No remarkable difference in the local structures around Pb and Bi atoms was observed. Across the temperature of the resistivity anomaly (T*), photoelectron holograms of Bi 4f changed. Comparisons of holograms with those of non-substituted LaOFBiS2 sample, as well as simulated holograms, suggested that (1), above T*, the tetragonal structure of Pb-LaOFBiS2 is different from the tetragonal structure of LaOFBiS2 and (2), below T*, the tetragonal structure still remains in Pb-LaOFBiS2. We discuss a possible origin of the difference in the structure above T* and the implication of the result below T*, which are necessary ingredients to understand the physical properties of Pb-LaOFBiS2. en-copyright= kn-copyright= en-aut-name=LiYajun en-aut-sei=Li en-aut-mei=Yajun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HashimotoYusuke en-aut-sei=Hashimoto en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KataokaNoriyuki en-aut-sei=Kataoka en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SunZexu en-aut-sei=Sun en-aut-mei=Zexu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KawamuraSota en-aut-sei=Kawamura en-aut-mei=Sota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TomitaHiroto en-aut-sei=Tomita en-aut-mei=Hiroto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SetoguchiTaro en-aut-sei=Setoguchi en-aut-mei=Taro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakeuchiSoichiro en-aut-sei=Takeuchi en-aut-mei=Soichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KogaShunjo en-aut-sei=Koga en-aut-mei=Shunjo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamagamiKohei en-aut-sei=Yamagami en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KotaniYoshinori en-aut-sei=Kotani en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=DemuraSatoshi en-aut-sei=Demura en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=NoguchiKanako en-aut-sei=Noguchi en-aut-mei=Kanako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=SakataHideaki en-aut-sei=Sakata en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=MatsushitaTomohiro en-aut-sei=Matsushita en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=WakitaTakanori en-aut-sei=Wakita en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=MuraokaYuji en-aut-sei=Muraoka en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=YokoyaTakayoshi en-aut-sei=Yokoya en-aut-mei=Takayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=5 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=6 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=7 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=8 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=9 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=10 en-affil=Japan Synchrotron Radiation Research Institute (JASRI) kn-affil= affil-num=11 en-affil=Japan Synchrotron Radiation Research Institute (JASRI) kn-affil= affil-num=12 en-affil=Department of Physics, College of Science and Technology(CST), Nihon University kn-affil= affil-num=13 en-affil=Tokyo University of Science kn-affil= affil-num=14 en-affil=Tokyo University of Science kn-affil= affil-num=15 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=16 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=17 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=18 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=5 article-no= start-page=387 end-page=399 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202410 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effect of Radon Inhalation on Murine Brain Proteins: Investigation Using Proteomic and Multivariate Analyses en-subtitle= kn-subtitle= en-abstract= kn-abstract=Radon is a known risk factor for lung cancer; however, it can be used beneficially, such as in radon therapy. We have previously reported the enhancement of antioxidant effects associated with trace amounts of oxidative stress as one of the positive biological effects of radon inhalation. However, the biological effects of radon inhalation are incompletely understood, and more detailed and comprehensive studies are required. Although several studies have used proteomics to investigate the effects of radon inhalation on body proteins, none has focused on brain proteins. In this study, we evaluated the expression status of proteins in murine brains using proteomic and multivariate analyses to identify those whose expressions changed following two days of radon inhalation at a concentration of 1,500 Bq/m3. We found associations of radon inhalation with the expressions of seven proteins related to neurotransmission and heat shock. These proteins may be proposed as biomarkers indicative of radon inhalation. Although further studies are required to obtain the detailed biological significance of these protein alterations, this study contributes to the elucidation of the biological effects of radon inhalation as a low-dose radiation. en-copyright= kn-copyright= en-aut-name=NaoeShota en-aut-sei=Naoe en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanakaAyumi en-aut-sei=Tanaka en-aut-mei=Ayumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KanzakiNorie en-aut-sei=Kanzaki en-aut-mei=Norie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakenakaReiju en-aut-sei=Takenaka en-aut-mei=Reiju kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyajiTakaaki en-aut-sei=Miyaji en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency kn-affil= affil-num=4 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=5 en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency kn-affil= affil-num=6 en-affil=Advanced Science Research Center, Okayama University kn-affil= affil-num=7 en-affil=Faculty of Health Sciences, Okayama University kn-affil= affil-num=8 en-affil=Faculty of Health Sciences, Okayama University kn-affil= en-keyword=radon inhalation kn-keyword=radon inhalation en-keyword=proteomics kn-keyword=proteomics en-keyword=multivariate analysis kn-keyword=multivariate analysis en-keyword=brain kn-keyword=brain en-keyword=oxidative stress kn-keyword=oxidative stress END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=4 article-no= start-page=349 end-page=355 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Middle-Ear Salivary Gland Choristoma with Congenital, Single-Sided Hearing Loss en-subtitle= kn-subtitle= en-abstract= kn-abstract=Middle-ear salivary gland choristoma (SGCh) is a rare, benign tumor that causes conductive hearing loss owing to middle-ear morphological abnormalities. Early diagnosis is challenging, and surgical resection is indispensable for a definitive diagnosis. We report the case of a 3-year-old boy diagnosed with middle-ear SGCh during the follow-up period for left-sided hearing loss discovered at newborn hearing screening (NHS). Long-term follow-up after the NHS result, subsequent computed tomography/magnetic resonance imaging, and surgical resection led to its relatively early diagnosis and treatment. en-copyright= kn-copyright= en-aut-name=TominagaYuichiro en-aut-sei=Tominaga en-aut-mei=Yuichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SugayaAkiko en-aut-sei=Sugaya en-aut-mei=Akiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KariyaShin en-aut-sei=Kariya en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShimizuAiko en-aut-sei=Shimizu en-aut-mei=Aiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KataokaYuko en-aut-sei=Kataoka en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AndoMizuo en-aut-sei=Ando en-aut-mei=Mizuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Otolaryngology, Head and Neck Surgery, Hiroshima City, Hiroshima Citizens Hospital kn-affil= affil-num=2 en-affil=Department of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Otolaryngology, Head and Neck Surgery, Kawasaki Medical School Hospital kn-affil= affil-num=4 en-affil=Department of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=middle-ear salivary gland choristoma kn-keyword=middle-ear salivary gland choristoma en-keyword=middle-ear morphological abnormalities kn-keyword=middle-ear morphological abnormalities en-keyword=newborn hearing screening kn-keyword=newborn hearing screening en-keyword=unilateral hearing loss kn-keyword=unilateral hearing loss en-keyword=surgical resection kn-keyword=surgical resection END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue= article-no= start-page=53 end-page=72 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20231228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Regional Measures to Maintain Public Transportation in Mountainous Areas―A Case Study of Mimasaka City, Okayama Prefecture― kn-title=中山間地域における公共交通維持に係る地域的対応―岡山県美作市を例に― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KATAOKAKatsumi en-aut-sei=KATAOKA en-aut-mei=Katsumi kn-aut-name=片岡克巳 kn-aut-sei=片岡 kn-aut-mei=克巳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院社会文化科学研究科 END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=12 article-no= start-page=125001 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20231121 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Photoelectron holographic evidence for the incorporation site of Se and suppressed atomic displacement of the conducting layer of La(O,F)BiSSe en-subtitle= kn-subtitle= en-abstract= kn-abstract=La(O,F)BiS2-xSex is a layered material that is considered to be a candidate exotic superconductor as well as a promising thermoelectrical material. We performed soft X-ray photoelectron holography to study the Se incorporation site and the local atomic arrangement of the conducting layer. A comparison of the experimental holograms with the simulated holograms indicates that Se atoms preferentially occupy the S sites in the conducting Bi–S plane of La(O,F)BiS2. A comparison between the state-of-the-art holographic reconstructions of La(O,F)BiSSe and La(O,F)BiS2 suggests that Se substitution suppresses the displacement of S atoms in La(O,F)BiS2. These results provide photoelectron holographic evidence for the Se incorporation site and the Se-induced suppression of in-plane disorder. en-copyright= kn-copyright= en-aut-name=LiYaJun en-aut-sei=Li en-aut-mei=YaJun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SunZeXu en-aut-sei=Sun en-aut-mei=ZeXu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KataokaNoriyuki en-aut-sei=Kataoka en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SetoguchiTaro en-aut-sei=Setoguchi en-aut-mei=Taro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HashimotoYusuke en-aut-sei=Hashimoto en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakeuchiSoichiro en-aut-sei=Takeuchi en-aut-mei=Soichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KogaShunjo en-aut-sei=Koga en-aut-mei=Shunjo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HoshiKazuhisa en-aut-sei=Hoshi en-aut-mei=Kazuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MizuguchiYoshikazu en-aut-sei=Mizuguchi en-aut-mei=Yoshikazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MatsushitaTomohiro en-aut-sei=Matsushita en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=WakitaTakanori en-aut-sei=Wakita en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MuraokaYuji en-aut-sei=Muraoka en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=YokoyaTakayoshi en-aut-sei=Yokoya en-aut-mei=Takayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Engineering Research Center of Integrated Circuit Packaging and Testing, Ministry of Education, Tianshui Normal University kn-affil= affil-num=2 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=6 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=7 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=8 en-affil=Department of Physics, Tokyo Metropolitan University kn-affil= affil-num=9 en-affil=Department of Physics, Tokyo Metropolitan University kn-affil= affil-num=10 en-affil=Nara Institute of Science and Technology (NAIST) kn-affil= affil-num=11 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=12 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=13 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=photoelectron holography kn-keyword=photoelectron holography en-keyword=La(O,F)BiS2-x Se x kn-keyword=La(O,F)BiS2-x Se x en-keyword=local structure kn-keyword=local structure en-keyword=dopant site kn-keyword=dopant site END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=6 article-no= start-page=589 end-page=593 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Cochlear Implantation in the Poorer-Hearing Ear Is a Reasonable Choice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Choosing the optimal side for cochlear implantation (CI) remains a major challenge because of the lack of evidence. We investigated the choice of the surgery side for CI (i.e., the better- or poorer-hearing ear) in patients with asymmetric hearing. Audiological records of 74 adults with a unilateral hearing aid who had undergone surgery at Okayama University Hospital were reviewed. The definition of ‘better-hearing ear’ was the aided ear, and the unaided ear was considered the poorer-hearing ear. We performed a multiple regression analysis to identify potential predictors of speech recognition performance after unilateral CI in the patients. Fifty-two patients underwent CI in the poorer-hearing ear. The post-Ci bimodal hearing rate was far higher in the poorer-ear group (77.8% vs. 22.2%). A multivariate analysis revealed that prelingual hearing loss and the patient’s age at CI significantly affected the speech recognition outcome (beta coefficients: 24.6 and −0.33, 95% confidence intervals [11.75-37.45] and [−0.58 to −0.09], respectively), but the CI surgery side did not (−6.76, [−14.92-1.39]). Unilateral CI in the poorer-hearing ear may therefore be a reasonable choice for adult patients with postlingual severe hearing loss, providing a greater opportunity for postoperative bimodal hearing. en-copyright= kn-copyright= en-aut-name=OmichiRyotaro en-aut-sei=Omichi en-aut-mei=Ryotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KariyaShin en-aut-sei=Kariya en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MaedaYukihide en-aut-sei=Maeda en-aut-mei=Yukihide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FukushimaKunihiro en-aut-sei=Fukushima en-aut-mei=Kunihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KataokaYuko en-aut-sei=Kataoka en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SugayaAkiko en-aut-sei=Sugaya en-aut-mei=Akiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NishizakiKazunori en-aut-sei=Nishizaki en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=AndoMizuo en-aut-sei=Ando en-aut-mei=Mizuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Otolaryngology-Head and Neck Surgery, Kawasaki Medial University kn-affil= affil-num=3 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Hayashima Clinic of Otolaryngology and Dermatology kn-affil= affil-num=5 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=cochlear implantation kn-keyword=cochlear implantation en-keyword=poorer hearing ear kn-keyword=poorer hearing ear en-keyword=better hearing ear kn-keyword=better hearing ear en-keyword=hearing aids kn-keyword=hearing aids en-keyword=speech recognition kn-keyword=speech recognition END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20051231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=右室低形成を伴う純型肺動脈閉鎖・肺動脈狭窄症に対する治療戦略 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡功一 kn-aut-sei=片岡 kn-aut-mei=功一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=4 article-no= start-page=387 end-page=394 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Association between Radon Hot Spring Bathing and Health Conditions: A Cross-Sectional Study in Misasa, Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=No epidemiological studies have examined the health effects of daily bathing in radon hot springs. In this cross-sectional study, we investigated the associations between radon hot spring bathing and health conditions. The target population was 5,250 adults ≥ 20 years old in the town of Misasa, Japan. We collected information about the participants’ bathing habits and alleviation of a variety of disease symptoms, and their self-rated health (SRH). Unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI) were calculated. In both the adjusted and unadjusted models of hypertension, significant associations between the > 1×/week hot spring bathing and the alleviation of hypertension symptoms were observed compared to the group whose hot spring bathing was <1×/week: adjusted model, OR 5.40 (95%CI: 1.98-14.74); unadjusted model, 3.67 (1.50-8.99) and for gastroenteritis: adjusted model, 9.18 (1.15-72.96); unadjusted model, 7.62 (1.59-36.49). Compared to the no-bathing group, higher SRH was significantly associated with both bathing < 1×/week: unadjusted model, 2.27 (1.53-3.37) and > 1×/week: adjusted model, 1.91 (1.15-3.19). These findings suggest that bathing in radon hot springs is associated with higher SRH and the alleviation of hypertension and gastroenteritis. en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HabuHiroshi en-aut-sei=Habu en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TanakaAyumi en-aut-sei=Tanaka en-aut-mei=Ayumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NaoeShota en-aut-sei=Naoe en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MurakamiKaito en-aut-sei=Murakami en-aut-mei=Kaito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FujimotoYuki en-aut-sei=Fujimoto en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YukimineRyohei en-aut-sei=Yukimine en-aut-mei=Ryohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakaoSoshi en-aut-sei=Takao en-aut-mei=Soshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Radiological Technology, Okayama University Graduate School of Health Sciences kn-affil= affil-num=2 en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Radiological Technology, Okayama University Graduate School of Health Sciences kn-affil= affil-num=4 en-affil=Department of Radiological Technology, Okayama University Graduate School of Health Sciences kn-affil= affil-num=5 en-affil=Department of Radiological Technology, Okayama University Graduate School of Health Sciences kn-affil= affil-num=6 en-affil=Department of Radiological Technology, Okayama University Graduate School of Health Sciences kn-affil= affil-num=7 en-affil=Department of Radiological Technology, Okayama University Graduate School of Health Sciences kn-affil= affil-num=8 en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Longevity and Social Medicine (Geriatrics), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Radiological Technology, Okayama University Graduate School of Health Sciences kn-affil= en-keyword=radon hot spring kn-keyword=radon hot spring en-keyword=bathing habit kn-keyword=bathing habit en-keyword=self-rated health kn-keyword=self-rated health en-keyword=cross-section study kn-keyword=cross-section study END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=2023 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Important things in school life for elementary, junior high, and high school students with hearing loss: 20 tips to support them better: Teacher’s Edition -simplified version- en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaYuko en-aut-sei=Kataoka en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Otolaryngology, Okayama University Hospital kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=2023 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=How to Support People with APD kn-title=Communication Support for People with APD: Schools/Workplaces en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaYuko en-aut-sei=Kataoka en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Otolaryngology, Okayama University Hospital kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230615 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Important things in school life for elementary, junior high, and high school students with hearing loss (Teacher’s Edition) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaYuko en-aut-sei=Kataoka en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakagawaAtsuko en-aut-sei=Nakagawa en-aut-mei=Atsuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Okayama University Hospital Hearing Health Center kn-affil= affil-num=2 en-affil=Okayama University Hospital Hearing Health Center kn-affil= END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=4 article-no= start-page=635 end-page=643 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230517 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of low-dose/high-dose-rate X-irradiation on oxidative stress in organs following forced swim test and its combined effects on alcohol-induced liver damage in mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=The liver's susceptibility to oxidative stress after a combination of forced swim test (FST) and low-dose-rate gamma-irradiation has been observed. Therefore, this study aims to clarify the effects of low-dose (0.1 and 0.5 Gy)/high-dose-rate (1.2 Gy/min) irradiation on combined oxidative stressors-liver damage associated with FST and alcohol administration. In addition, the effects of similar irradiation on FST-induced immobility, which induces psychomotor retardation, and antioxidative effects on the brain, lungs, liver and kidneys were investigated, and the results were compared with those of a similar previous study that utilized low-dose-rate irradiation. Low-dose/high-dose-rate (especially 0.5 Gy) irradiation temporarily worsened liver antioxidant function and hepatic function with FST- and alcohol administration-related oxidative damage; however, the damages improved soon after. In addition, the increase in total glutathione content in the liver contributed to the early improvement of hepatic functions. However, pre-irradiation did not suppress immobility during the FST. The results also suggested that the effects of low-dose/high-dose-rate irradiation on the antioxidant functions of each organ after the FST were different from those of low-dose/low-dose-rate irradiation. Overall, this study provides further insights into the effects of low-dose irradiation on exposure to a combination of different oxidative stressors. It will also contribute to the elucidation of dose rate effects on oxidative stress in the low-dose irradiation range. en-copyright= kn-copyright= en-aut-name=NaoeShota en-aut-sei=Naoe en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujimotoYuki en-aut-sei=Fujimoto en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MurakamiKaito en-aut-sei=Murakami en-aut-mei=Kaito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YukimineRyohei en-aut-sei=Yukimine en-aut-mei=Ryohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanakaAyumi en-aut-sei=Tanaka en-aut-mei=Ayumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=6 en-affil=Faculty of Health Sciences, Okayama University kn-affil= affil-num=7 en-affil=Faculty of Health Sciences, Okayama University kn-affil= en-keyword=low-dose/high-dose-rate irradiation kn-keyword=low-dose/high-dose-rate irradiation en-keyword=forced swim test kn-keyword=forced swim test en-keyword=alcohol kn-keyword=alcohol en-keyword=oxidative stress kn-keyword=oxidative stress en-keyword=antioxidants kn-keyword=antioxidants END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=17 article-no= start-page=10632 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220826 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Immunomodulatory Effects of Radon Inhalation on Lipopolysaccharide-Induced Inflammation in Mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Typical indications for radon therapy include autoimmune diseases such as rheumatoid arthritis (RA). We had previously reported that radon inhalation inhibits Th17 immune responses in RA mice by activating Th1 and Th2 immune responses. However, there are no reports on how radon inhalation affects the activated Th1 and Th17 immune responses, and these findings may be useful for identifying new indications for radon therapy. Therefore, in this study, we investigated the effect of radon inhalation on the lipopolysaccharide (LPS)-induced inflammatory response, focusing on the expression of related cytokines and antioxidant function. Male BALB/c mice were exposed to 2000 Bq/m(3) radon for one day. Immediately after radon inhalation, LPS was administered intraperitoneally at 1.0 mg/kg body weight for 4 h. LPS administration increased the levels of Th1- and Th17-prone cytokines, such as interleukin-2, tumor necrosis factor-alpha, and granulocyte-macrophage colony-stimulating factor, compared to no treatment control (sham). However, these effects were suppressed by radon inhalation. IL-10 levels were significantly increased by LPS administration, with or without radon inhalation, compared to sham. However, radon inhalation did not inhibit oxidative stress induced by LPS administration. These findings suggest that radon inhalation has immunomodulatory but not antioxidative functions in LPS-induced injury. en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NaoeShota en-aut-sei=Naoe en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MurakamiKaito en-aut-sei=Murakami en-aut-mei=Kaito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FujimotoYuki en-aut-sei=Fujimoto en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YukimineRyohei en-aut-sei=Yukimine en-aut-mei=Ryohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TanakaAyumi en-aut-sei=Tanaka en-aut-mei=Ayumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Faculty of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=7 en-affil=Faculty of Health Sciences, Okayama University kn-affil= en-keyword=autoimmune diseases kn-keyword=autoimmune diseases en-keyword=cytokine kn-keyword=cytokine en-keyword=antioxidant function kn-keyword=antioxidant function en-keyword=lipopolysaccharide kn-keyword=lipopolysaccharide en-keyword=radon inhalation kn-keyword=radon inhalation END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220711 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Potential inhibitory effects of low-dose thoron inhalation and ascorbic acid administration on alcohol-induced hepatopathy in mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although thoron inhalation exerts antioxidative effects in several organs, there are no reports on whether it inhibits oxidative stress-induced damage. In this study, we examined the combined effects of thoron inhalation and ascorbic acid (AA) administration on alcohol-induced liver damage. Mice were subjected to thoron inhalation at 500 or 2000 Bq/m(3) and were administered 50% ethanol (alcohol) and 300 mg/kg AA. Results showed that although alcohol administration increased the levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in the serum, the combination of thoron inhalation (500 Bq/m(3)) and AA administration 24 h after alcohol administration effectively inhibited alcohol-induced liver damage. The combination of thoron inhalation (500 Bq/m(3)) and AA administration 24 h after alcohol administration increased catalase (CAT) activity. Alcohol administration significantly decreased glutathione (GSH) levels in the liver. The GSH content in the liver after 2000 Bq/m(3) thoron inhalation was lower than that after 500 Bq/m(3) thoron inhalation. These findings suggest that the combination of thoron inhalation at 500 Bq/m(3) and AA administration has positive effects on the recovery from alcohol-induced liver damage. The results also suggested that thoron inhalation at 500 Bq/m(3) was more effective than that at 2000 Bq/m(3), possibly because of the decrease in GSH content in the liver. In conclusion, the combination of thoron inhalation at 500 Bq/m(3) and AA administration promoted an early recovery from alcohol-induced liver damage. en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IshidaTsuyoshi en-aut-sei=Ishida en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NaoeShota en-aut-sei=Naoe en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KanzakiNorie en-aut-sei=Kanzaki en-aut-mei=Norie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TanakaHiroshi en-aut-sei=Tanaka en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=4 en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency kn-affil= affil-num=5 en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency kn-affil= affil-num=6 en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency kn-affil= affil-num=7 en-affil=Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= en-keyword=alcohol-induced liver damage kn-keyword=alcohol-induced liver damage en-keyword=oxidative stress kn-keyword=oxidative stress en-keyword=antioxidative function kn-keyword=antioxidative function en-keyword=ascorbic acid (AA) kn-keyword=ascorbic acid (AA) en-keyword=thoron kn-keyword=thoron END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue=5 article-no= start-page=1000 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220510 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Maternal Gut Microbiome Decelerates Fetal Endochondral Bone Formation by Inducing Inflammatory Reaction en-subtitle= kn-subtitle= en-abstract= kn-abstract=To investigate the effect of the maternal gut microbiome on fetal endochondral bone formation, fetuses at embryonic day 18 were obtained from germ-free (GF) and specific-pathogen-free (SPF) pregnant mothers. Skeletal preparation of the fetuses' whole bodies did not show significant morphological alterations; however, micro-CT analysis of the tibiae showed a lower bone volume fraction in the SPF tibia. Primary cultured chondrocytes from fetal SPF rib cages showed a lower cell proliferation and lower accumulation of the extracellular matrix. RNA-sequencing analysis showed the induction of inflammation-associated genes such as the interleukin (IL) 17 receptor, IL 6, and immune-response genes in SPF chondrocytes. These data indicate that the maternal gut microbiome in SPF mice affects fetal embryonic endochondral ossification, possibly by changing the expression of genes related to inflammation and the immune response in fetal cartilage. The gut microbiome may modify endochondral ossification in the fetal chondrocytes passing through the placenta. en-copyright= kn-copyright= en-aut-name=Uchida-FukuharaYoko en-aut-sei=Uchida-Fukuhara en-aut-mei=Yoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HattoriTakako en-aut-sei=Hattori en-aut-mei=Takako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FuShanqi en-aut-sei=Fu en-aut-mei=Shanqi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KondoSei en-aut-sei=Kondo en-aut-mei=Sei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KuwaharaMiho en-aut-sei=Kuwahara en-aut-mei=Miho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FukuharaDaiki en-aut-sei=Fukuhara en-aut-mei=Daiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IslamMd Monirul en-aut-sei=Islam en-aut-mei=Md Monirul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KataokaKota en-aut-sei=Kataoka en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=EkuniDaisuke en-aut-sei=Ekuni en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KubotaSatoshi en-aut-sei=Kubota en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MoritaManabu en-aut-sei=Morita en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=IikegameMika en-aut-sei=Iikegame en-aut-mei=Mika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=OkamuraHirohiko en-aut-sei=Okamura en-aut-mei=Hirohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Department of Oral Morphology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Biochemistry and Molecular Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Biochemistry and Molecular Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Biochemistry and Molecular Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Biochemistry and Molecular Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Preventive Dentistry, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Biochemistry and Molecular Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Oral Morphology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=13 en-affil=Department of Oral Morphology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=maternal microbiome kn-keyword=maternal microbiome en-keyword=endochondral ossification kn-keyword=endochondral ossification en-keyword=fetal chondrocytes kn-keyword=fetal chondrocytes END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=2 article-no= start-page=87 end-page=92 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=2022 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Confirmation of efficacy, elucidation of mechanism, and new search for indications of radon therapy en-subtitle= kn-subtitle= en-abstract= kn-abstract=Indications of radon therapy include various diseases related to respiratory, painful, digestive, chronic degenerative, senile, etc. derived from reactive oxygen species, but most are based on empirical prescriptions. For this reason, we have evaluated the relation between the biological response caused by radon and the tissue/organ absorbed dose more quantitatively, and have promoted the elucidation of mechanisms related to the indication and searching newly. As a result, as a mechanism, a series of moderate physiological stimulative effects accompanying a small amount of oxidative stress by radon inhalation are being elucidated. That is, hyperfunction of anti-oxidation/immune regulation/damage repair, promotion of anti-inflammation/circulating metabolism/hormone secretion, induction of apoptosis/heat shock protein, etc. Also, new indications include inflammatory/neuropathic pain, hepatic/renal injury, colitis, type 1 diabetes, complication kidney injury, hyperuricemia, transient cerebral ischemia, and inflammatory edema. Furthermore, we examined the combined antioxidant effect of radon inhalation and antioxidants or therapeutic agents. As a result, it was clear that any combination treatment could enhance the suppression effect of disease. It can be expected that radon therapy can be used effectively by applying it in addition to usual treatment, since reduction in its dosage can also be expected by concomitant use for drugs with strong side effects. en-copyright= kn-copyright= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Health Sciences, Institute of Academic and Research, Okayama University kn-affil= affil-num=2 en-affil=Health Sciences, Institute of Academic and Research, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=2 article-no= start-page=154 end-page=159 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=2022 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model en-subtitle= kn-subtitle= en-abstract= kn-abstract=The typical indication of radon therapy is rheumatoid arthritis. Although there are several reports that radon therapy has regulation effects on Th17 cells, there has been no study reporting that radon inhalation affects the immune balance among Th1, Th2, and Th17. The purpose of this study is to examine the cytokine changes after radon inhalation. BALB/c mice inhaled radon at 2,000 Bq/m3 for 2 or 4 weeks. SKG/Jcl mice inhaled radon at 2,000 Bq/m3 for 4 weeks after zymosan administration. The results showed that radon inhalation for 4 weeks activated the immune response of Th1, Th2, and Th17. Moreover, the balance among them was not lost by radon inhalation. Radon inhalation for 4 weeks decreased superoxide dismutase activity and increased catalase activity in spleen. These findings suggest that an imbalance of oxidative stress may contribute to activate the immune response. Although zymosan administration activated Th17 immune response and decreased Th1 and Th2 immune response in SKG/Jcl mice, most cytokines related to Th1, Th2, and Th17 approached the normal level by radon inhalation. These findings suggested that radon inhalation has a different action between SKG/Jcl mice and normal BABL/c mice. This may indicate that radon inhalation has an immunomodulation function. en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NaoeShota en-aut-sei=Naoe en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MurakamiKaito en-aut-sei=Murakami en-aut-mei=Kaito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YukimineRyohei en-aut-sei=Yukimine en-aut-mei=Ryohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujimotoYuki en-aut-sei=Fujimoto en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KanzakiNorie en-aut-sei=Kanzaki en-aut-mei=Norie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=6 en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency kn-affil= affil-num=7 en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency kn-affil= affil-num=8 en-affil=Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= en-keyword=radon kn-keyword=radon en-keyword=cytokine kn-keyword=cytokine en-keyword=oxidative stress kn-keyword=oxidative stress en-keyword=rheumatoid arthritis kn-keyword=rheumatoid arthritis en-keyword=immunomodulation function kn-keyword=immunomodulation function END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202204 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=難聴をもつ小・中・高校生の学校生活で大切なこと : 難聴児への関わり方がよく分かる20のヒント : 先生編, 1枚で理解できる！簡略版 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaYuko en-aut-sei=Kataoka en-aut-mei=Yuko kn-aut-name=片岡祐子 kn-aut-sei=片岡 kn-aut-mei=祐子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院 耳鼻咽喉科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=How to Support People with APD kn-title=APDの方へのコミュニケーション支援 : 学校・職場編 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaYuko en-aut-sei=Kataoka en-aut-mei=Yuko kn-aut-name=片岡祐子 kn-aut-sei=片岡 kn-aut-mei=祐子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院耳鼻咽喉科 END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=5 article-no= start-page=861 end-page=867 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210809 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions en-subtitle= kn-subtitle= en-abstract= kn-abstract=Radon inhalation decreases the level of lipid peroxide (LPO); this is attributed to the activation of antioxidative functions. This activation contributes to the beneficial effects of radon therapy, but there are no studies on the risks of radon therapy, such as DNA damage. We evaluated the effect of radon inhalation on DNA damage caused by oxidative stress and explored the underlying mechanisms. Mice were exposed to radon inhalation at concentrations of 2 or 20 kBq/m(3) (for one, three, or 10 days). The 8-hydroxy-2 '-deoxyguanosine (8-OHdG) levels decreased in the brains of mice that inhaled 20 kBq/m(3) radon for three days and in the kidneys of mice that inhaled 2 or 20 kBq/m(3) radon for one, three or 10 days. The 8-OHdG levels in the small intestine decreased by approximately 20-40% (2 kBq/m(3) for three days or 20 kBq/m(3) for one, three or 10 days), but there were no significant differences in the 8-OHdG levels between mice that inhaled a sham treatment and those that inhaled radon. There was no significant change in the levels of 8-oxoguanine DNA glycosylase, which plays an important role in DNA repair. However, the level of Mn-superoxide dismutase (SOD) increased by 15-60% and 15-45% in the small intestine and kidney, respectively, following radon inhalation. These results suggest that Mn-SOD probably plays an important role in the inhibition of oxidative DNA damage. en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShutoHina en-aut-sei=Shuto en-aut-mei=Hina kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NaoeShota en-aut-sei=Naoe en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YanoJunki en-aut-sei=Yano en-aut-mei=Junki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KanzakiNorie en-aut-sei=Kanzaki en-aut-mei=Norie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanakaHiroshi en-aut-sei=Tanaka en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HanamotoKatsumi en-aut-sei=Hanamoto en-aut-mei=Katsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TeratoHiroaki en-aut-sei=Terato en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=5 en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency kn-affil= affil-num=6 en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency kn-affil= affil-num=7 en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency kn-affil= affil-num=8 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=9 en-affil=Graduate School ofMedicine Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Advanced Science Research Center Okayama University kn-affil= affil-num=11 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= en-keyword=radon kn-keyword=radon en-keyword=oxidative DNA damage kn-keyword=oxidative DNA damage en-keyword=Mn-superoxide dismutase (SOD) kn-keyword=Mn-superoxide dismutase (SOD) en-keyword=8-oxoguanine DNA glycosylase kn-keyword=8-oxoguanine DNA glycosylase END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=3 article-no= start-page=390 end-page=400 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210127 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Evaluation of the redox state in mouse organs following radon inhalation en-subtitle= kn-subtitle= en-abstract= kn-abstract=Radon inhalation activates antioxidative functions in mouse organs, thereby contributing to inhibition of oxidative stress-induced damage. However, the specific redox state of each organ after radon inhalation has not been reported. Therefore, in this study, we evaluated the redox state of various organs in mice following radon inhalation at concentrations of 2 or 20 kBq/m(3) for 1, 3 or 10 days. Scatter plots were used to evaluate the relationship between antioxidative function and oxidative stress by principal component analysis (PCA) of data from control mice subjected to sham inhalation. The results of principal component (PC) 1 showed that the liver and kidney had high antioxidant capacity; the results of PC2 showed that the brain, pancreas and stomach had low antioxidant capacities and low lipid peroxide (LPO) content, whereas the lungs, heart, small intestine and large intestine had high LPO content but low antioxidant capacities. Furthermore, using the PCA of each obtained cluster, we observed altered correlation coefficients related to glutathione, hydrogen peroxide and LPO for all groups following radon inhalation. Correlation coefficients related to superoxide dismutase in organs with a low antioxidant capacity were also changed. These findings suggested that radon inhalation could alter the redox state in organs; however, its characteristics were dependent on the total antioxidant capacity of the organs as well as the radon concentration and inhalation time. The insights obtained from this study could be useful for developing therapeutic strategies targeting individual organs. en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KanzakiNorie en-aut-sei=Kanzaki en-aut-mei=Norie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShutoHina en-aut-sei=Shuto en-aut-mei=Hina kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YanoJunki en-aut-sei=Yano en-aut-mei=Junki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NaoeShota en-aut-sei=Naoe en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanakaHiroshi en-aut-sei=Tanaka en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HanamotoKatsumi en-aut-sei=Hanamoto en-aut-mei=Katsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TeratoHiroaki en-aut-sei=Terato en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency kn-affil= affil-num=3 en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency kn-affil= affil-num=4 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=7 en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency kn-affil= affil-num=8 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=9 en-affil=Advanced Science Research Center, Okayama University kn-affil= affil-num=10 en-affil=Graduate School ofMedicine Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= en-keyword=radon kn-keyword=radon en-keyword=redox state kn-keyword=redox state en-keyword=oxidative stress kn-keyword=oxidative stress en-keyword=antioxidative function kn-keyword=antioxidative function en-keyword=principal component analysis kn-keyword=principal component analysis END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue=5 article-no= start-page=587 end-page=597 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Unusual oral mucosal microbiota after hematopoietic cell transplantation with glycopeptide antibiotics: potential association with pathophysiology of oral mucositis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Severe oral mucositis occurs frequently in patients receiving hematopoietic stem cell transplantation (HCT). Oral mucosal bacteria can be associated with progression of oral mucositis, and systemic infection may occur via ulcerative oral mucositis. However, little information is available regarding the oral microbiota after HCT. Here, PCR-denaturing gradient gel electrophoresis (DGGE) was performed to characterize the oral mucosal microbiota, which can be affected by antibiotics, before and after HCT. Sixty reduced-intensity HCT patients were enrolled. Three patients with the least antibiotic use (quinolone prophylaxis and/or β-lactam monotherapy group) and three patients with the most antibiotic use (β-lactam-glycopeptide combination therapy group) were selected. Bacterial DNA samples obtained from the oral mucosa before and after HCT were subjected to PCR-DGGE. The trajectory of oral mucositis was evaluated. The oral mucosal microbiota in the β-lactam-glycopeptide combination therapy group was different from that in the quinolone prophylaxis and/or β-lactam monotherapy group, and Staphylococcus spp. and Enterococcus spp. were identified. Lautropia mirabilis was dominant in one patient. Ulcerative oral mucositis was observed only in the β-lactam-glycopeptide combination therapy group. In conclusion, especially with the use of strong antibiotics, such as glycopeptides, the oral mucosal microbiota differed completely from that under normal conditions, and consisted of Staphylococcus spp., Enterococcus spp., and unexpectedly L. mirabilis. The normal oral microbiota consists not only of bacteria, but these unexpected bacteria could be involved in the pathophysiology as well as systemic infection via oral mucositis. Our results can be used as the basis for future studies in larger patient populations. en-copyright= kn-copyright= en-aut-name=MuroMisato en-aut-sei=Muro en-aut-mei=Misato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SogaYoshihiko en-aut-sei=Soga en-aut-mei=Yoshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HiguchiTomoko en-aut-sei=Higuchi en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KataokaKota en-aut-sei=Kataoka en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=EkuniDaisuke en-aut-sei=Ekuni en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MoritaManabu en-aut-sei=Morita en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Division of Hospital Dentistry, Okayama University Hospital kn-affil= affil-num=2 en-affil=Division of Hospital Dentistry, Okayama University Hospital kn-affil= affil-num=3 en-affil=Division of Hospital Dentistry, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=hematopoietic stem cell transplantation kn-keyword=hematopoietic stem cell transplantation en-keyword=oral mucositis kn-keyword=oral mucositis en-keyword=microbiota kn-keyword=microbiota en-keyword=antibiotics kn-keyword=antibiotics en-keyword=PCR-denaturing gradient gel electrophoresis kn-keyword=PCR-denaturing gradient gel electrophoresis END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210506 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=難聴をもつ小・中・高校生の学校生活で大切なこと : 先生編 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaYuko en-aut-sei=Kataoka en-aut-mei=Yuko kn-aut-name=片岡祐子 kn-aut-sei=片岡 kn-aut-mei=祐子 aut-affil-num=1 ORCID= en-aut-name=NakagawaAtsuko en-aut-sei=Nakagawa en-aut-mei=Atsuko kn-aut-name=中川敦子 kn-aut-sei=中川 kn-aut-mei=敦子 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院 耳鼻咽喉科 affil-num=2 en-affil= kn-affil=岡山大学病院 耳鼻咽喉科 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=2 article-no= start-page=169 end-page=175 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Effects of Low-Dose-Rate γ-irradiation on Forced Swim Test-Induced Immobility and Oxidative Stress in Mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=The forced swim test (FST) induces immobility in mice. Low-dose (high-dose-rate) X-irradiation inhibits FSTinduced immobility in mice due to its antioxidative function. We evaluated the effects of low-dose γ-irradiation at a low-dose-rate on the FST-induced depletion of antioxidants in mouse organs. Mice received whole-body low-dose-rate (0.6 or 3.0 mGy/h) of low-dose γ-irradiation for 1 week, followed by daily FSTs (5 days). The immobility rate on day 2 compared to day 1 was significantly lower in the 3.0 mGy/h irradiated mice than in sham irradiated mice. The FST significantly decreased the catalase (CAT) activity and total glutathione (t-GSH) content in the brain and kidney, respectively. The superoxide dismutase (SOD) activity and t-GSH content in the liver of the 3.0 mGy/h irradiated mice were significantly lower than those of the non-FST-treated mice. The CAT activity in the lungs of mice exposed to 3.0 mGy/h γ-irradiation was higher than that of non-FST treated mice and mice treated with FST. However, no significant differences were observed in the levels of these antioxidant markers between the sham and irradiated groups except for the CAT activity in lungs. These findings suggest that the effects of low-dose-rate and low-dose γ-irradiation on FST are highly organ-dependent. en-copyright= kn-copyright= en-aut-name=NakadaTetsuya en-aut-sei=Nakada en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NomuraTakaharu en-aut-sei=Nomura en-aut-mei=Takaharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShutoHina en-aut-sei=Shuto en-aut-mei=Hina kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YanoJunki en-aut-sei=Yano en-aut-mei=Junki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NaoeShota en-aut-sei=Naoe en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HanamotoKatsumi en-aut-sei=Hanamoto en-aut-mei=Katsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Central Research Institute of Electric Power Industry kn-affil= affil-num=4 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=7 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=8 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= en-keyword=low-dose-rate γ-irradiation kn-keyword=low-dose-rate γ-irradiation en-keyword=forced swim test kn-keyword=forced swim test en-keyword=antioxidant kn-keyword=antioxidant en-keyword=oxidative stress kn-keyword=oxidative stress END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=3 article-no= start-page=035501 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20201016 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Soft x-ray irradiation induced metallization of layered TiNCl en-subtitle= kn-subtitle= en-abstract= kn-abstract=We have performed soft x-ray spectroscopy in order to study the photoirradiation time dependence of the valence band structure and chemical states of layered transition metal nitride chloride TiNCl. Under the soft x-ray irradiation, the intensities of the states near the Fermi level (EF) and the Ti3+ component increased, while the Cl 2p intensity decreased. Ti 2p–3d resonance photoemission spectroscopy confirmed a distinctive Fermi edge with Ti 3d character. These results indicate the photo-induced metallization originates from deintercalation due to Cl desorption, and thus provide a new carrier doping method that controls the conducting properties of TiNCl. en-copyright= kn-copyright= en-aut-name=KataokaNoriyuki en-aut-sei=Kataoka en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanakaMasashi en-aut-sei=Tanaka en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HosodaWataru en-aut-sei=Hosoda en-aut-mei=Wataru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TaniguchiTakumi en-aut-sei=Taniguchi en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujimoriShin-ichi en-aut-sei=Fujimori en-aut-mei=Shin-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=WakitaTakanori en-aut-sei=Wakita en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MuraokaYuji en-aut-sei=Muraoka en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YokoyaTakayoshi en-aut-sei=Yokoya en-aut-mei=Takayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Engineering, Kyushu Institute of Technology kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Materials Sciences Research Center, Japan Atomic Energy Agency kn-affil= affil-num=6 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=7 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=8 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=18 cd-vols= no-issue=1 article-no= start-page=324 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210105 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Living with Family Is Directly Associated with Regular Dental Checkup and Indirectly Associated with Gingival Status among Japanese University Students: A 3-Year Cohort Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although some studies showed that lifestyle was associated with oral health behavior, few studies investigated the association between household type and oral health behavior. The aim of this prospective cohort study was to investigate the association between household type, oral health behavior, and periodontal status among Japanese university students. Data were obtained from 377 students who received oral examinations and self-questionnaires in 2016 and 2019. We assessed periodontal status using the percentage of bleeding on probing (%BOP), probing pocket depth, oral hygiene status, oral health behaviors, and related factors. We used structural equation modeling to determine the association between household type, oral health behaviors, gingivitis, and periodontitis. At follow-up, 252 students did not live with their families. The mean +/- standard deviation of %BOP was 35.5 +/- 24.7 at baseline and 32.1 +/- 25.3 at follow-up. In the final model, students living with their families were significantly more likely to receive regular dental checkup than those living alone. Regular checkup affected the decrease in calculus. The decrease in calculus affected the decrease in %BOP over 3 years. Living with family was directly associated with regular dental checkups and indirectly contributed to gingival status among Japanese university students. en-copyright= kn-copyright= en-aut-name=NakaharaMomoko en-aut-sei=Nakahara en-aut-mei=Momoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=EkuniDaisuke en-aut-sei=Ekuni en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KataokaKota en-aut-sei=Kataoka en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YokoiAya en-aut-sei=Yokoi en-aut-mei=Aya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=Uchida-FukuharaYoko en-aut-sei=Uchida-Fukuhara en-aut-mei=Yoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FukuharaDaiki en-aut-sei=Fukuhara en-aut-mei=Daiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KobayashiTerumasa en-aut-sei=Kobayashi en-aut-mei=Terumasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ToyamaNaoki en-aut-sei=Toyama en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SahoHikari en-aut-sei=Saho en-aut-mei=Hikari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IslamMd Monirul en-aut-sei=Islam en-aut-mei=Md Monirul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MoritaManabu en-aut-sei=Morita en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Preventive Dentistry, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Preventive Dentistry, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Preventive Dentistry, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Health Service Center, Okayama University kn-affil= affil-num=12 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=lifestyle kn-keyword=lifestyle en-keyword=dental health behavior kn-keyword=dental health behavior en-keyword=oral health kn-keyword=oral health en-keyword=oral hygiene kn-keyword=oral hygiene en-keyword=gingivitis kn-keyword=gingivitis en-keyword=behavioral sciences kn-keyword=behavioral sciences END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=4 article-no= start-page=517 end-page=523 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200429 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=X-Irradiation at 0.5 Gy after the forced swim test reduces forced swimming-induced immobility in mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=The forced swim test (FST) is a screening model for antidepressant activity; it causes immobility and induces oxidative stress. We previously reported that radon inhalation has antidepressant-like effects in mice potentially through the activation of antioxidative functions upon radon inhalation. This study aimed to investigate the effect of prior and post low-dose X-irradiation (0.1, 0.5, 1.0 and 2.0 Gy) on FST-induced immobility and oxidative stress in the mouse brain, and the differences, if any, between the two. Mice received X-irradiation before or after the FST repeatedly for 5 days. In the post-FST-irradiated group, an additional FST was conducted 4h after the last irradiation. Consequently, animals receiving prior X-irradiation (0.1 Gy) had better mobility outcomes than sham-irradiated mice; however, their levels of lipid peroxide (LPO), an oxidative stress marker, remained unchanged. However, animals that received post-FST X-irradiation (0.5 Gy) had better mobility outcomes and their LPO levels were significantly lower than those of the sham-irradiated mice. The present results indicate that 0.5 Gy X-irradiation after FST inhibits FST-induced immobility and oxidative stress in mice. en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShutoHina en-aut-sei=Shuto en-aut-mei=Hina kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YanoJunki en-aut-sei=Yano en-aut-mei=Junki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NaoeShota en-aut-sei=Naoe en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IshidaTsuyoshi en-aut-sei=Ishida en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakadaTetsuya en-aut-sei=Nakada en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamatoKeiko en-aut-sei=Yamato en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HanamotoKatsumi en-aut-sei=Hanamoto en-aut-mei=Katsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NomuraTakaharu en-aut-sei=Nomura en-aut-mei=Takaharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=7 en-affil=Laboratory of Neurology and Neurosurgery, National Cerebral and Cardiovascular Center kn-affil= affil-num=8 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=9 en-affil=Central Research Institute of Electric Power Industry kn-affil= affil-num=10 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= en-keyword=X-irradiation kn-keyword=X-irradiation en-keyword=forced swim test kn-keyword=forced swim test en-keyword=antioxidants kn-keyword=antioxidants en-keyword=brain kn-keyword=brain en-keyword=oxidative stress kn-keyword=oxidative stress END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=7 article-no= start-page=e0236259 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200723 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Relationship between oral hygiene knowledge, source of oral hygiene knowledge and oral hygiene behavior in Japanese university students: A prospective cohort study en-subtitle= kn-subtitle= en-abstract= kn-abstract=The aim of this prospective cohort study was to examine whether oral hygiene knowledge, and the source of that knowledge, affect oral hygiene behavior in university students in Japan. An oral exam and questionnaire survey developed to evaluate oral hygiene knowledge, the source of that knowledge, and oral hygiene behavior, such as the frequency of tooth brushing and regular dental checkups and the use of dental floss, was conducted on university student volunteers. In total, 310 students with poor tooth brushing behavior (frequency of tooth brushing per day [<= once]), 1,963 who did not use dental floss, and 1,882 who did not receive regular dental checkup during the past year were selected. Among these students, 50, 364, and 343 in each respective category were analyzed in over the 3-year study period (follow-up rates: 16.1%, 18.5%, and 18.2%, respectively). The odds ratios (ORs) and 95% confidence intervals (CIs) for oral hygiene behavior were calculated based on oral hygiene knowledge and the source of that knowledge using logistic regression models. The results showed that dental clinics were the most common (> 50%) source of oral hygiene knowledge, and that a more frequent use of dental floss was significantly associated with dental clinics being a source of oral hygiene knowledge (OR, 4.11; 95%CI, 1.871-9.029; p < 0.001). In addition, a significant association was seen between dental clinics being a source of oral hygiene knowledge and more frequent regular dental checkups (OR, 13.626; 95%CI, 5.971-31.095; p < 0.001). These findings suggest the existence of a relationship between dental clinics being the most common source of oral hygiene knowledge and improved oral hygiene behavior in Japanese university students. en-copyright= kn-copyright= en-aut-name=FukuharaDaiki en-aut-sei=Fukuhara en-aut-mei=Daiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=EkuniDaisuke en-aut-sei=Ekuni en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KataokaKota en-aut-sei=Kataoka en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=Taniguchi-TabataAyano en-aut-sei=Taniguchi-Tabata en-aut-mei=Ayano kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=Uchida-FukuharaYoko en-aut-sei=Uchida-Fukuhara en-aut-mei=Yoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ToyamaNaoki en-aut-sei=Toyama en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YonedaToshiki en-aut-sei=Yoneda en-aut-mei=Toshiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SugiuraYoshio en-aut-sei=Sugiura en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=IslamMonirul en-aut-sei=Islam en-aut-mei=Monirul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=SahoHikari en-aut-sei=Saho en-aut-mei=Hikari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MoritaManabu en-aut-sei=Morita en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Preventive Dentistry, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Preventive Dentistry, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Preventive Dentistry, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Health Service Center, Okayama University kn-affil= affil-num=12 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=2 article-no= start-page=13 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=1974 dt-pub=19740325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=岡大本『三勇和歌集』について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡智子 kn-aut-sei=片岡 kn-aut-mei=智子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ノートルダム清心女子大学 END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue=1 article-no= start-page=175 end-page=178 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201305 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Peritonsillar abscess with otorrhea kn-title=耳漏を主訴に来院した扁桃周囲膿瘍の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= The patient was a 79-year-old woman. Her left ear was being treated with otitis externa at her nearby clinic by eardrop. Her otorrhea did not improve after one week. The otorrhea still kept outflowing during food intake. That is the reason of her visiting our hospital. Her past medical histories were sigmoid colon perforation with stoma placement, rheumatoid arthritis, diabetes mellitus, hypertension, right hip prosthesis placement. At the first visit to our hospita!, She had a remarkable erosion of the left ear canal, fistula was found in front of the ear canal skin. She showed pus leakage due to her chewing. Strongly swelling surrounded the left tonsil and soft palate, and oropharynx had been narrowed. T he CT scan revealed the low density area with a contrast effect from the lower ear to the left tonsil, was diagnosed with left peritonsillar abscess. On admission to our hospital, drainage and the administration of antibiotics were performed. She was discharged in satisfactory progress on day 10. Peritonsillar abscess, but there is a frequently encountered disease, being the chief complaint otorrhea is rare. As reported case seems to be similar as far as we have searched is only reported as "one case of deep neck abscess in the throat and ear canal causing self-destruction" is Tomohiro Anno 1961. We report this case with the literature about peritonsillar abscess. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大道亮太郎 kn-aut-sei=大道 kn-aut-mei=亮太郎 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡祐子 kn-aut-sei=片岡 kn-aut-mei=祐子 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=石原久司 kn-aut-sei=石原 kn-aut-mei=久司 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西﨑和則 kn-aut-sei=西﨑 kn-aut-mei=和則 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 医歯薬学総合研究科 耳鼻咽喉・頭頸部外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院 医歯薬学総合研究科 耳鼻咽喉・頭頸部外科学 affil-num=3 en-affil= kn-affil=香川労災病院耳鼻咽喉科・頭頸部外科 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科耳鼻咽喉・頭頸部外科学 END start-ver=1.4 cd-journal=joma no-vol=17 cd-vols= no-issue=10 article-no= start-page=3713 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200525 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Caries Increment and Salivary Microbiome during University Life: A Prospective Cohort Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=The purpose of this 3-year prospective cohort study was to explore the relationship between an increase in dental caries and oral microbiome among Japanese university students. We analyzed 487 students who volunteered to receive oral examinations and answer baseline (2013) and follow-up (2016) questionnaires. Of these students, salivary samples were randomly collected from 55 students at follow-up and analyzed using next-generation sequencing. Students were divided into two groups: increased group (Delta decayed, missing, and filled teeth (Delta DMFT) score increased during the 3-year period) and non-increased group (Delta DMFT did not increase). Thirteen phyla, 21 classes, 32 orders, 48 families, 72 genera, and 156 species were identified. Microbial diversity in the increased group (n = 14) was similar to that in the non-increased group (n = 41). Relative abundances of the family Prevotellaceae (p = 0.007) and genera Alloprevotella (p = 0.007) and Dialister (p = 0.039) were enriched in the increased group compared with the non-increased group. Some bacterial taxonomic clades were differentially present between the two groups. These results may contribute to the development of new dental caries prevention strategies, including the development of detection kits and enlightenment activities for these bacteria. en-copyright= kn-copyright= en-aut-name=Uchida-FukuharaYoko en-aut-sei=Uchida-Fukuhara en-aut-mei=Yoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=EkuniDaisuke en-aut-sei=Ekuni en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IslamMd Monirul en-aut-sei=Islam en-aut-mei=Md Monirul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KataokaKota en-aut-sei=Kataoka en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=Taniguchi-TabataAyano en-aut-sei=Taniguchi-Tabata en-aut-mei=Ayano kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FukuharaDaiki en-aut-sei=Fukuhara en-aut-mei=Daiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ToyamaNaoki en-aut-sei=Toyama en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KobayashiTerumasa en-aut-sei=Kobayashi en-aut-mei=Terumasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FujimoriKohei en-aut-sei=Fujimori en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=SawadaNanami en-aut-sei=Sawada en-aut-mei=Nanami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MoritaManabu en-aut-sei=Morita en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Preventive Dentistry, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School kn-affil= affil-num=5 en-affil=Department of Preventive Dentistry, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Preventive Dentistry, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Health Service Center, Okayama University kn-affil= affil-num=12 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=salivary microbiome kn-keyword=salivary microbiome en-keyword=sequence analysis kn-keyword=sequence analysis en-keyword=young adult kn-keyword=young adult en-keyword=dental caries kn-keyword=dental caries en-keyword=saliva kn-keyword=saliva en-keyword=oral health kn-keyword=oral health END start-ver=1.4 cd-journal=joma no-vol=17 cd-vols= no-issue=9 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200427 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Association between Sleep Quality and Duration and Periodontal Disease among University Students: A Cross-Sectional Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=The purpose of this cross-sectional study was to investigate the association between sleep quality and duration, and periodontal disease among a group of young Japanese university students. First-year students (n = 1934) at Okayama University who voluntarily underwent oral health examinations were included in the analysis. Sleep quality and duration were assessed by the Japanese version of the Pittsburgh Sleep Quality Index. Dentists examined Oral Hygiene Index-Simplified (OHI-S), probing pocket depth (PPD), and percentage of sites with bleeding on probing (BOP). Periodontal disease was defined as presence of PPD >= 4 mm and BOP >= 30%. Overall, 283 (14.6%) students had periodontal disease. Poor sleep quality was observed among 372 (19.2%) students. Mean (+/- standard deviation) sleep duration was 7.1 +/- 1.1 (hours/night). In the logistic regression analysis, periodontal disease was significantly associated with OHI-S (odds ratio [OR]: 2.30, 95% confident interval [CI]: 1.83-2.90; p < 0.001), but not sleep quality (OR: 1.09, 95% CI: 0.79-1.53; p = 0.577) or sleep duration (OR: 0.98, CI: 0.87-1.10; p = 0.717). In conclusion, sleep quality and duration were not associated with periodontal disease among this group of young Japanese university students. en-copyright= kn-copyright= en-aut-name=IslamMd Monirul en-aut-sei=Islam en-aut-mei=Md Monirul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=EkuniDaisuke en-aut-sei=Ekuni en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ToyamaNaoki en-aut-sei=Toyama en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=Taniguchi-TabataAyano en-aut-sei=Taniguchi-Tabata en-aut-mei=Ayano kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KataokaKota en-aut-sei=Kataoka en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=Uchida-FukuharaYoko en-aut-sei=Uchida-Fukuhara en-aut-mei=Yoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=FukuharaDaiki en-aut-sei=Fukuhara en-aut-mei=Daiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SahoHikari en-aut-sei=Saho en-aut-mei=Hikari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SawadaNanami en-aut-sei=Sawada en-aut-mei=Nanami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NakashimaYukiho en-aut-sei=Nakashima en-aut-mei=Yukiho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MoritaManabu en-aut-sei=Morita en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Preventive Dentistry, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Preventive Dentistry, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Preventive Dentistry, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Preventive Dentistry, Okayama University Hospital kn-affil= affil-num=11 en-affil=Health Service Center, Okayama University kn-affil= affil-num=12 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=sleep quality kn-keyword=sleep quality en-keyword=sleep duration kn-keyword=sleep duration en-keyword=periodontal disease kn-keyword=periodontal disease en-keyword=university students kn-keyword=university students END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year= dt-pub= dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Rumex dentatus L. subsp. klotzschianus (Meisn.) Rech.f. kn-title=コギシギシ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-keyword=タデ科 (Polygonaceae) kn-keyword=タデ科 (Polygonaceae) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue=3 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200422 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Comparison of antioxidative effects between radon and thoron inhalation in mouse organs en-subtitle= kn-subtitle= en-abstract= kn-abstract=Radon therapy has been traditionally performed globally for oxidative stress-related diseases. Many researchers have studied the beneficial effects of radon exposure in living organisms. However, the effects of thoron, a radioisotope of radon, have not been fully examined. In this study, we aimed to compare the biological effects of radon and thoron inhalation on mouse organs with a focus on oxidative stress. Male BALB/c mice were randomly divided into 15 groups: sham inhalation, radon inhalation at a dose of 500 Bq/m3 or 2000 Bq/m3, and thoron inhalation at a dose of 500 Bq/m3 or 2000 Bq/m3 were carried out. Immediately after inhalation, mouse tissues were excised for biochemical assays. The results showed a significant increase in superoxide dismutase and total glutathione, and a significant decrease in lipid peroxide following thoron inhalation under several conditions. Additionally, similar effects were observed for different doses and inhalation times between radon and thoron. Our results suggest that thoron inhalation also exerts antioxidative effects against oxidative stress in organs. However, the inhalation conditions should be carefully analyzed because of the differences in physical characteristics between radon and thoron. en-copyright= kn-copyright= en-aut-name=KobashiYusuke en-aut-sei=Kobashi en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KanzakiNorie en-aut-sei=Kanzaki en-aut-mei=Norie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IshidaTsuyoshi en-aut-sei=Ishida en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TanakaHiroshi en-aut-sei=Tanaka en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IshimoriYuu en-aut-sei=Ishimori en-aut-mei=Yuu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=5 en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency kn-affil= affil-num=6 en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency kn-affil= affil-num=7 en-affil=Prototype Fast Breeder Reactor Monju, Japan Atomic Energy Agency kn-affil= affil-num=8 en-affil=Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= en-keyword=Radon kn-keyword=Radon en-keyword=Thoron kn-keyword=Thoron en-keyword=Oxidative stress kn-keyword=Oxidative stress en-keyword=Antioxidative function kn-keyword=Antioxidative function END start-ver=1.4 cd-journal=joma no-vol=130 cd-vols= no-issue=3 article-no= start-page=167 end-page=172 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20181203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=General Practitioner kn-title=総合診療専門医 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ObikaMikako en-aut-sei=Obika en-aut-mei=Mikako kn-aut-name=小比賀美香子 kn-aut-sei=小比賀 kn-aut-mei=美香子 aut-affil-num=1 ORCID= en-aut-name=KataokaHitomi en-aut-sei=Kataoka en-aut-mei=Hitomi kn-aut-name=片岡仁美 kn-aut-sei=片岡 kn-aut-mei=仁美 aut-affil-num=2 ORCID= en-aut-name=OgawaHiroko en-aut-sei=Ogawa en-aut-mei=Hiroko kn-aut-name=小川弘子 kn-aut-sei=小川 kn-aut-mei=弘子 aut-affil-num=3 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name=大塚文男 kn-aut-sei=大塚 kn-aut-mei=文男 aut-affil-num=4 ORCID= affil-num=1 en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=2 en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=3 en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=4 en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科 en-keyword=新専門医制度 kn-keyword=新専門医制度 en-keyword=総合診療専門医 kn-keyword=総合診療専門医 END start-ver=1.4 cd-journal=joma no-vol=130 cd-vols= no-issue=2 article-no= start-page=91 end-page=93 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Anti-resorptive agents-related osteonecrosis of the jaw kn-title=骨吸収抑制薬関連顎骨壊死 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaYuko en-aut-sei=Kataoka en-aut-mei=Yuko kn-aut-name=片岡祐子 kn-aut-sei=片岡 kn-aut-mei=祐子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Otolaryngology Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　耳鼻咽喉・頭頸部外科学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=RUNX3の欠失は、肝細胞癌において5-FUとシスプラチンの抵抗性を誘発する kn-title=Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaJunro en-aut-sei=Kataoka en-aut-mei=Junro kn-aut-name=片岡淳朗 kn-aut-sei=片岡 kn-aut-mei=淳朗 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=大学生におけるブラキシズムの自覚と不正咬合との関連についての横断研究 kn-title=Association Between Self-Reported Bruxism and Malocclusion in University Students: A Cross-Sectional Study en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaKota en-aut-sei=Kataoka en-aut-mei=Kota kn-aut-name=片岡広太 kn-aut-sei=片岡 kn-aut-mei=広太 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue= article-no= start-page=51 end-page=60 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170327 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An Attempt at Curriculum Improvement through an Evaluation by External Experienced Childcare Workers kn-title=カリキュラム改善における園外の保育経験者による評価導入の試み en-subtitle= kn-subtitle= en-abstract=　We commissioned external seven childcare workers with experience of early childhood education and care to evaluate the curriculum of a nursery school. Evaluation results reflected wide points of view based on the experiences of each evaluator. It was possible to specify the items of "unification of transcription and expression, and adoption of the plain style," "making of a plan in conformity with originality in facilities and the reality of the child," "making of a preservation of health plan," "reorganization by the PDCA cycle," and "confirmation between the staff" as factors related to curriculum improvement. The validity of the external evaluation by the childcare workers with experience was confirmed as a policy of curriculum improvement. kn-abstract=　本論は，保育現場における園のカリキュラム・マネジメントを活性化させるために，園外の保育経験者にカリキュラムの外部評価を依頼し，その評価内容と一連の評価方法について検討するものである。具体的には，地方政令市にあるA 保育園のカリキュラムを取り上げ，保育所保育士経験者及び幼稚園教諭経験者によって構成させる７名の外部評価者から，カリキュラムの評価を得た。その結果，外部評価者の勤務経験の違いを反映した，幅広い観点から，カリキュラムの評価できる点や問題点を確認することができた。カリキュラム改善の観点としては，「表記・表現の統一と分かりやすい様式の採用」「園の独自性や子どもの実態に即した計画の作成」「保健計画の作成」「PDCA サイクルによる再編成」「職員間での確認」の項目を明示することができた。カリキュラム改善の一方策として，保育経験者による外部評価に一定の有効性を確認した。 en-copyright= kn-copyright= en-aut-name=BabaNoriko en-aut-sei=Baba en-aut-mei=Noriko kn-aut-name=馬場訓子 kn-aut-sei=馬場 kn-aut-mei=訓子 aut-affil-num=1 ORCID= en-aut-name=ShimizuMariko en-aut-sei=Shimizu en-aut-mei=Mariko kn-aut-name=清水眞里子 kn-aut-sei=清水 kn-aut-mei=眞里子 aut-affil-num=2 ORCID= en-aut-name=IyamaFusako en-aut-sei=Iyama en-aut-mei=Fusako kn-aut-name=井山房子 kn-aut-sei=井山 kn-aut-mei=房子 aut-affil-num=3 ORCID= en-aut-name=KataokaKayoko en-aut-sei=Kataoka en-aut-mei=Kayoko kn-aut-name=片岡加代子 kn-aut-sei=片岡 kn-aut-mei=加代子 aut-affil-num=4 ORCID= en-aut-name=KoyanoHiroko en-aut-sei=Koyano en-aut-mei=Hiroko kn-aut-name=古埜弘子 kn-aut-sei=古埜 kn-aut-mei=弘子 aut-affil-num=5 ORCID= en-aut-name=ShiragamiShigeko en-aut-sei=Shiragami en-aut-mei=Shigeko kn-aut-name=白神繁子 kn-aut-sei=白神 kn-aut-mei=繁子 aut-affil-num=6 ORCID= en-aut-name=HiramatsuYumiko en-aut-sei=Hiramatsu en-aut-mei=Yumiko kn-aut-name=平松由美子 kn-aut-sei=平松 kn-aut-mei=由美子 aut-affil-num=7 ORCID= en-aut-name=HachiyaSachiko en-aut-sei=Hachiya en-aut-mei=Sachiko kn-aut-name=蜂谷幸子 kn-aut-sei=蜂谷 kn-aut-mei=幸子 aut-affil-num=8 ORCID= en-aut-name=NishiyamaOsamu en-aut-sei=Nishiyama en-aut-mei=Osamu kn-aut-name=西山修 kn-aut-sei=西山 kn-aut-mei=修 aut-affil-num=9 ORCID= affil-num=1 en-affil=Faculty of Childhood Education, Kurashiki Sakuyo University kn-affil=くらしき作陽大学子ども教育学部 affil-num=2 en-affil=Faculty of Childhood Education, Kurashiki Sakuyo University kn-affil=くらしき作陽大学子ども教育学部 affil-num=3 en-affil=Faculty of Childhood Education, Kurashiki Sakuyo University kn-affil=くらしき作陽大学子ども教育学部 affil-num=4 en-affil=Faculty of Childhood Education, Kurashiki Sakuyo University kn-affil=くらしき作陽大学子ども教育学部 affil-num=5 en-affil=Department of Music, Sakuyo Junior College of Music kn-affil=作陽音楽短期大学音楽学科 affil-num=6 en-affil=Department of Music, Sakuyo Junior College of Music kn-affil=作陽音楽短期大学音楽学科 affil-num=7 en-affil=Faculty of Childhood Education, Kurashiki Sakuyo University kn-affil=くらしき作陽大学子ども教育学部 affil-num=8 en-affil= kn-affil=作陽音楽短期大学音楽学科 affil-num=9 en-affil=Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科 en-keyword=カリキュラム改善 (curriculum improvement) kn-keyword=カリキュラム改善 (curriculum improvement) en-keyword=保育経験者 (the childcare workers with experience) kn-keyword=保育経験者 (the childcare workers with experience) en-keyword=外部評価 (external evaluation) kn-keyword=外部評価 (external evaluation) en-keyword=評価の観点 (viewpoints of evaluation) kn-keyword=評価の観点 (viewpoints of evaluation) END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=原因不明の不育症女性における自律神経活動の変化 kn-title=Altered autonomic nervous system activity in women with unexplained recurrent pregnancy loss en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaKumie en-aut-sei=Kataoka en-aut-mei=Kumie kn-aut-name=片岡久美恵 kn-aut-sei=片岡 kn-aut-mei=久美恵 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=歯槽骨再生を目的としたin vivo electroporation法を用いたラット歯周組織への遺伝子導入 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaYohei en-aut-sei=Kataoka en-aut-mei=Yohei kn-aut-name=片岡陽平 kn-aut-sei=片岡 kn-aut-mei=陽平 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=1 article-no= start-page=19 end-page=23 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Surgically treated Zenker’s diverticulum： Diverticulectomy and cricopharyngeal myotomy kn-title=憩室切除と輪状咽頭筋切開術を行ったZenker憩室症の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　Zenker's diverticulum is a very rare disease among gastorointestinal diverticulum. We report a case of Zenker's diverticulum successfully treated with diverticulectomy and cricophalyngial myotomy. A 71-year-old male complained of aspirating water for two years. He was diagnosed as Zenker's diverticulum. Due to his severe symptoms, the operation was performed in an open-neck approach. The left recurrent laryngeal nerve was identified and preserved. An incision was made in the diverticulum wall, and the internal diameter of normal cervical esophagus was measured. The diverticulum was then excised with an automatic suture device in the minor axis direction of the esophagus. A cricopharyngeal myotomy was conducted, because this muscle was fibrotic and stiffened. The patient's symptoms disappeared after the operation. Diverticulectomy and cricopharyngeal myotomy through an open-neck approach is a safe and reliable method that follows, direct access to the diverticulum and recurrent laryngeal nerve. en-copyright= kn-copyright= en-aut-name=NinomiyaTakayuki en-aut-sei=Ninomiya en-aut-mei=Takayuki kn-aut-name=二宮卓之 kn-aut-sei=二宮 kn-aut-mei=卓之 aut-affil-num=1 ORCID= en-aut-name=KanayaNobuhiko en-aut-sei=Kanaya en-aut-mei=Nobuhiko kn-aut-name=金谷信彦 kn-aut-sei=金谷 kn-aut-mei=信彦 aut-affil-num=2 ORCID= en-aut-name=KatsudaKoh en-aut-sei=Katsuda en-aut-mei=Koh kn-aut-name=勝田浩 kn-aut-sei=勝田 kn-aut-mei=浩 aut-affil-num=3 ORCID= en-aut-name=TanakayaKohji en-aut-sei=Tanakaya en-aut-mei=Kohji kn-aut-name=田中屋宏爾 kn-aut-sei=田中屋 kn-aut-mei=宏爾 aut-affil-num=4 ORCID= en-aut-name=AokiHideki en-aut-sei=Aoki en-aut-mei=Hideki kn-aut-name=青木秀樹 kn-aut-sei=青木 kn-aut-mei=秀樹 aut-affil-num=5 ORCID= en-aut-name=TakeuchiHitoshi en-aut-sei=Takeuchi en-aut-mei=Hitoshi kn-aut-name=竹内仁司 kn-aut-sei=竹内 kn-aut-mei=仁司 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構岩国医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構岩国医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構岩国医療センター　外科 affil-num=4 en-affil= kn-affil=国立病院機構岩国医療センター　外科 affil-num=5 en-affil= kn-affil=国立病院機構岩国医療センター　外科 affil-num=6 en-affil= kn-affil=国立病院機構岩国医療センター　外科 en-keyword=Zenker憩室（Zenker’s diverticulum） kn-keyword=Zenker憩室（Zenker’s diverticulum） en-keyword=輪状咽頭筋切開術（cricopharyngeal myotomy） kn-keyword=輪状咽頭筋切開術（cricopharyngeal myotomy） en-keyword=頚部アプローチ（open-neck approach） kn-keyword=頚部アプローチ（open-neck approach） END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=1 article-no= start-page=13 end-page=17 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Okayama University Survey of the current situation of community-based medical facilities supported by part-time work by physicians kn-title=岡山大学勤務医師による非常勤勤務を通した地域医療支援の現状調査 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　We investigated the situation of how physicians at Okayama University support local medical institutions by serving as a part-time worker, and analyzed the difference between the five medical districts of Okayama prefecture and other prefectures. Many physicians (actual number of physicians, full-time equivalent number of physicians) served in the southeastern region of the Okayama prefecture (339, 82.2). On the other hand, fewer physicians (42, 11.4) served in Takahashi・Niimi in the northwestern region of Okayama. Many physicians also served in Hiroshima prefecture (193, 48.8), Hyogo prefecture (109, 26.7), and the four prefectures of Shikoku Island (81, 23.6). 　It has been clarified that many physicians at Okayama University are working on a part-time basis to support local and community medical institutions in the wide area of Okayama prefecture, Hiroshima prefecture, Hyogo prefecture and the four prefectures of Shikoku Island. en-copyright= kn-copyright= en-aut-name=TeshigawaraSanae en-aut-sei=Teshigawara en-aut-mei=Sanae kn-aut-name=勅使川早苗 kn-aut-sei=勅使川 kn-aut-mei=早苗 aut-affil-num=1 ORCID= en-aut-name=IwaseToshihide en-aut-sei=Iwase en-aut-mei=Toshihide kn-aut-name=岩瀬敏秀 kn-aut-sei=岩瀬 kn-aut-mei=敏秀 aut-affil-num=2 ORCID= en-aut-name=KanamoriTatsuya en-aut-sei=Kanamori en-aut-mei=Tatsuya kn-aut-name=金森達也 kn-aut-sei=金森 kn-aut-mei=達也 aut-affil-num=3 ORCID= en-aut-name=KawabataTomoko en-aut-sei=Kawabata en-aut-mei=Tomoko kn-aut-name=川畑智子 kn-aut-sei=川畑 kn-aut-mei=智子 aut-affil-num=4 ORCID= en-aut-name=SatoMasaru en-aut-sei=Sato en-aut-mei=Masaru kn-aut-name=佐藤勝 kn-aut-sei=佐藤 kn-aut-mei=勝 aut-affil-num=5 ORCID= en-aut-name=Usui KataokaHitomi en-aut-sei=Usui Kataoka en-aut-mei=Hitomi kn-aut-name=片岡仁美 kn-aut-sei=片岡 kn-aut-mei=仁美 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　地域医療人材育成 affil-num=2 en-affil= kn-affil=岡山県地域医療支援センター　岡山大学支部 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　地域医療人材育成 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　地域医療人材育成 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　地域医療人材育成 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　地域医療人材育成 en-keyword=岡山大学勤務医師（physicians at Okayama University） kn-keyword=岡山大学勤務医師（physicians at Okayama University） en-keyword=非常勤勤務（part-time worker） kn-keyword=非常勤勤務（part-time worker） en-keyword=地域医療機関支援（community-based medical facilities） kn-keyword=地域医療機関支援（community-based medical facilities） END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=3 article-no= start-page=241 end-page=243 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20141201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Guidelines for acute otitis media in children kn-title=小児急性中耳炎診療ガイドライン en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaYuko en-aut-sei=Kataoka en-aut-mei=Yuko kn-aut-name=片岡祐子 kn-aut-sei=片岡 kn-aut-mei=祐子 aut-affil-num=1 ORCID= en-aut-name=NishizakiKazunori en-aut-sei=Nishizaki en-aut-mei=Kazunori kn-aut-name=西﨑和則 kn-aut-sei=西﨑 kn-aut-mei=和則 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　耳鼻咽喉・頭頸部外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　耳鼻咽喉・頭頸部外科学 END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=3 article-no= start-page=223 end-page=226 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20141201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of microscopic low-grade appendiceal mucinous neoplasm complicated with appendicitis resected by reduced-port laparoscopic surgery kn-title=Reduced Port Surgeryで切除した高度炎症を伴う虫垂中に発見された潜在性虫垂粘液嚢胞腺腫の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Appendicitis is a benign disease for which surgical treatment is widely provided. The complication of neoplastic lesions may be discovered only after resection. However, in some cases, specimens are not submitted to histopathological examination in Japan because of an extreme deficiency of pathologists. We report our experience with one patient who experienced the complication of latent low-grade appendiceal mucinous neoplasm (LAMN) after surgery for appendicitis. Our patient was an 85-year-old woman. Conservative treatment failed to relieve fever and lower abdominal pain and it was decided to treat her surgically. Abdominal computed tomography (CT) showed appendicitis with severe inflammation and suspected adhesion. We decided to explore the abdominal cavity using a reduced-port laparoscopic approach. We found no mucous debouchment or clear tumors in the specimen. Histopathological findings indicated the coexistence of appendicitis and LAMN. At one year and a half after surgery, there was no evidence of the development of pseudomyxoma peritonei. In appendectomy, it is thought that careful perioperative treatment and a postoperative pathological search are important when there are no preoperative findings suggesting a neoplastic lesion. en-copyright= kn-copyright= en-aut-name=SuzukiHiromitsu en-aut-sei=Suzuki en-aut-mei=Hiromitsu kn-aut-name=鈴木宏光 kn-aut-sei=鈴木 kn-aut-mei=宏光 aut-affil-num=1 ORCID= en-aut-name=KimuraKouji en-aut-sei=Kimura en-aut-mei=Kouji kn-aut-name=木村紘爾 kn-aut-sei=木村 kn-aut-mei=紘爾 aut-affil-num=2 ORCID= en-aut-name=KinoshitaSigeki en-aut-sei=Kinoshita en-aut-mei=Sigeki kn-aut-name=木下茂喜 kn-aut-sei=木下 kn-aut-mei=茂喜 aut-affil-num=3 ORCID= en-aut-name=OkanoKazuo en-aut-sei=Okano en-aut-mei=Kazuo kn-aut-name=岡野和雄 kn-aut-sei=岡野 kn-aut-mei=和雄 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=倉敷市立児島市民病院　外科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　呼吸器・乳腺内分泌外科学 affil-num=3 en-affil= kn-affil=倉敷市立児島市民病院　外科 affil-num=4 en-affil= kn-affil=倉敷市立児島市民病院　外科 en-keyword=虫垂炎（appendicitis） kn-keyword=虫垂炎（appendicitis） en-keyword=減孔式腹腔鏡手術（reduced-port laparoscopic surgery） kn-keyword=減孔式腹腔鏡手術（reduced-port laparoscopic surgery） en-keyword=虫垂粘液嚢胞腺腫（low-grade appendiceal mucinous neoplasm (LAMN)） kn-keyword=虫垂粘液嚢胞腺腫（low-grade appendiceal mucinous neoplasm (LAMN)） en-keyword=腹膜偽粘液腫（pseudomyxoma peritonei） kn-keyword=腹膜偽粘液腫（pseudomyxoma peritonei） en-keyword=腹腔鏡下虫垂切除術（laparoscopic appendectomy） kn-keyword=腹腔鏡下虫垂切除術（laparoscopic appendectomy） END start-ver=1.4 cd-journal=joma no-vol=22 cd-vols= no-issue=13 article-no= start-page=652 end-page=654 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110914 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Expression analysis of microRNAs in murine cochlear explants en-subtitle= kn-subtitle= en-abstract= kn-abstract=MicroRNAs (miRNAs) play functional roles in sound transduction in cochlea. This study focuses on the validity of cochlear culture as an in vitro experimental tool, in view of miRNA expression. E15 cochleae were dissected and maintained in vitro for 48 h before extraction of miRNAs. MiRNA expression was comprehensively screened in explanted cochleae using a miRNA array that covers 380 miRNAs. A strong correlation was observed between expression levels of miRNAs in in vitro and in in vivo cochleae. Levels of 43 miRNAs were altered in vitro and these changes were reproducible over three trials. These findings indicate that in vitro miRNA profiling is a viable method for analysis of gene expression and action of chemical compounds on cochleae. en-copyright= kn-copyright= en-aut-name=HiraiMisato en-aut-sei=Hirai en-aut-mei=Misato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MaedaYukihide en-aut-sei=Maeda en-aut-mei=Yukihide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FukushimaKunihiro en-aut-sei=Fukushima en-aut-mei=Kunihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SugayaAkiko en-aut-sei=Sugaya en-aut-mei=Akiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KataokaYuko en-aut-sei=Kataoka en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NishizakiKazunori en-aut-sei=Nishizaki en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharm, Dept Otolaryngol Head & Neck Surg affil-num=2 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharm, Dept Otolaryngol Head & Neck Surg affil-num=3 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharm, Dept Otolaryngol Head & Neck Surg affil-num=4 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharm, Dept Otolaryngol Head & Neck Surg affil-num=5 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharm, Dept Otolaryngol Head & Neck Surg affil-num=6 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharm, Dept Otolaryngol Head & Neck Surg en-keyword=embryonic cochlea kn-keyword=embryonic cochlea en-keyword=microRNA array kn-keyword=microRNA array en-keyword=organ culture of cochlea kn-keyword=organ culture of cochlea END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=4 article-no= start-page=235 end-page=241 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Factors Associated with Remission and/or Regression of Microalbuminuria in Type 2 Diabetes Mellitus en-subtitle= kn-subtitle= en-abstract= kn-abstract=The aim of this study was to clarify the factors associated with the remission and/or regression of microalbuminuria in Japanese patients with type 2 diabetes mellitus. We retrospectively analyzed the data of 130 patients with type 2 diabetes mellitus with microalbuminuria for 2-6 years (3.39±1.31 years). Remission was defined as improving from microalbuminuria to normoalbuminuria using the albumin/creatinine ratio (ACR), and regression of microalbuminuria was defined as a decrease in ACR of 50% or more from baseline. Progression of microalbuminuria was defined as progressing from microalbuminuria to overt proteinuria during the follow-up period. Among 130 patients with type 2 diabetes mellitus with microalbuminuria, 57 and 13 patients were defined as having remission and regression, respectively, while 26 patients progressed to overt proteinuria. Sex (female), higher HDL cholesterol and lower HbA1c were determinant factors associated with remission/regression of microalbuminuria by logistic regression analysis. Lower systolic blood pressure (SBP) was also correlated with remission/regression, but not at a significant level. These results suggest that proper control of blood glucose, BP and lipid profiles may be associated with remission and/or regression of type 2 diabetes mellitus with microalbuminuria in clinical practice. en-copyright= kn-copyright= en-aut-name=OnoTetsuichiro en-aut-sei=Ono en-aut-mei=Tetsuichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShikataKenichi en-aut-sei=Shikata en-aut-mei=Kenichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ObikaMikako en-aut-sei=Obika en-aut-mei=Mikako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiyatakeNobuyuki en-aut-sei=Miyatake en-aut-mei=Nobuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KoderaRyo en-aut-sei=Kodera en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HirotaDaisyo en-aut-sei=Hirota en-aut-mei=Daisyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KataokaHitomi en-aut-sei=Kataoka en-aut-mei=Hitomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OgawaDaisuke en-aut-sei=Ogawa en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Center for Graduate Medical Education, Okayama University affil-num=4 en-affil= kn-affil=Department of Hygiene, Faculty of Medicine, Kagawa University affil-num=5 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Diabetic Nephropathy, Okayama University affil-num=10 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=microalbuminuria kn-keyword=microalbuminuria en-keyword=type 2 diabetes mellitus kn-keyword=type 2 diabetes mellitus en-keyword=remission kn-keyword=remission en-keyword=regression kn-keyword=regression END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130120 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Pulmonary emphysema is characterized by alveolar destruction and persistent inflammation of the airways. Although IL-17A contributes to many chronic inflammatory diseases, it's role in the inflammatory response of elastase-induced emphysema remains unclear. Methods: In a model of elastase-induced pulmonary emphysema we examined the response of IL-17A-deficient mice, monitoring airway inflammation, static compliance, lung histology and levels of neutrophil-related chemokine and pro-inflammatory cytokines in bronchoalveolar lavage (BAL) fluid. Results: Wild-type mice developed emphysematous changes in the lung tissue on day 21 after elastase treatment, whereas emphysematous changes were decreased in IL-17A-deficient mice compared to wild-type mice. Neutrophilia in BAL fluid, seen in elastase-treated wild-type mice, was reduced in elastase-treated IL-17A-deficient mice on day 4, associated with decreased levels of KC, MIP-2 and IL-1 beta. Elastase-treated wild-type mice showed increased IL-17A levels as well as increased numbers of IL-17A+ CD4 T cells in the lung in the initial period following elastase treatment. Conclusions: These data identify the important contribution of IL-17A in the development of elastase-induced pulmonary inflammation and emphysema. Targeting IL-17A in emphysema may be a potential therapeutic strategy for delaying disease progression. en-copyright= kn-copyright= en-aut-name=KurimotoEtsuko en-aut-sei=Kurimoto en-aut-mei=Etsuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyaharaNobuaki en-aut-sei=Miyahara en-aut-mei=Nobuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KanehiroArihiko en-aut-sei=Kanehiro en-aut-mei=Arihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=WasedaKoichi en-aut-sei=Waseda en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TaniguchiAkihiko en-aut-sei=Taniguchi en-aut-mei=Akihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IkedaGenyo en-aut-sei=Ikeda en-aut-mei=Genyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KogaHikari en-aut-sei=Koga en-aut-mei=Hikari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NishimoriHisakazu en-aut-sei=Nishimori en-aut-mei=Hisakazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TanimotoYasushi en-aut-sei=Tanimoto en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IwakuraYoichiro en-aut-sei=Iwakura en-aut-mei=Yoichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=GelfandErwin W. en-aut-sei=Gelfand en-aut-mei=Erwin W. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol Oncol Allergy & Resp Med affil-num=2 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol Oncol Allergy & Resp Med affil-num=3 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol Oncol Allergy & Resp Med affil-num=4 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol Oncol Allergy & Resp Med affil-num=5 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol Oncol Allergy & Resp Med affil-num=6 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol Oncol Allergy & Resp Med affil-num=7 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol Oncol Allergy & Resp Med affil-num=8 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol Oncol Allergy & Resp Med affil-num=9 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol Oncol Allergy & Resp Med affil-num=10 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol Oncol Allergy & Resp Med affil-num=11 en-affil= kn-affil=Univ Tokyo, Inst Med Sci, Ctr Expt Med & Syst Biol affil-num=12 en-affil= kn-affil=Natl Jewish Hlth, Dept Pediat, Div Cell Biol affil-num=13 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol Oncol Allergy & Resp Med en-keyword=IL-17 kn-keyword=IL-17 en-keyword=Elastase kn-keyword=Elastase en-keyword=Emphysema kn-keyword=Emphysema en-keyword=Chronic obstructive pulmonary disease kn-keyword=Chronic obstructive pulmonary disease END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=1 article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophages kn-title=糖尿病の腎臓においてcholecystokininはマクロファージに対する抗炎症作用を介した新規の保護効果を発揮する en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MiyamotoSatoshi en-aut-sei=Miyamoto en-aut-mei=Satoshi kn-aut-name=宮本聡 kn-aut-sei=宮本 kn-aut-mei=聡 aut-affil-num=1 ORCID= en-aut-name=ShikataKenichi en-aut-sei=Shikata en-aut-mei=Kenichi kn-aut-name=四方賢一 kn-aut-sei=四方 kn-aut-mei=賢一 aut-affil-num=2 ORCID= en-aut-name=MiyasakaKyoko en-aut-sei=Miyasaka en-aut-mei=Kyoko kn-aut-name=宮坂京子 kn-aut-sei=宮坂 kn-aut-mei=京子 aut-affil-num=3 ORCID= en-aut-name=OkadaShinichi en-aut-sei=Okada en-aut-mei=Shinichi kn-aut-name=岡田震一 kn-aut-sei=岡田 kn-aut-mei=震一 aut-affil-num=4 ORCID= en-aut-name=SasakiMotofumi en-aut-sei=Sasaki en-aut-mei=Motofumi kn-aut-name=佐々木基史 kn-aut-sei=佐々木 kn-aut-mei=基史 aut-affil-num=5 ORCID= en-aut-name=KoderaRyo en-aut-sei=Kodera en-aut-mei=Ryo kn-aut-name=小寺亮 kn-aut-sei=小寺 kn-aut-mei=亮 aut-affil-num=6 ORCID= en-aut-name=HirotaDaisho en-aut-sei=Hirota en-aut-mei=Daisho kn-aut-name=廣田大昌 kn-aut-sei=廣田 kn-aut-mei=大昌 aut-affil-num=7 ORCID= en-aut-name=KajitaniNobuo en-aut-sei=Kajitani en-aut-mei=Nobuo kn-aut-name=梶谷展生 kn-aut-sei=梶谷 kn-aut-mei=展生 aut-affil-num=8 ORCID= en-aut-name=TakatsukaTetsuharu en-aut-sei=Takatsuka en-aut-mei=Tetsuharu kn-aut-name=高塚哲全 kn-aut-sei=高塚 kn-aut-mei=哲全 aut-affil-num=9 ORCID= en-aut-name=Kataoka UsuiHitomi en-aut-sei=Kataoka Usui en-aut-mei=Hitomi kn-aut-name=片岡仁美 kn-aut-sei=片岡 kn-aut-mei=仁美 aut-affil-num=10 ORCID= en-aut-name=NishishitaShingo en-aut-sei=Nishishita en-aut-mei=Shingo kn-aut-name=西下伸吾 kn-aut-sei=西下 kn-aut-mei=伸吾 aut-affil-num=11 ORCID= en-aut-name=Horiguchi SatoChikage en-aut-sei=Horiguchi Sato en-aut-mei=Chikage kn-aut-name=堀口千景 kn-aut-sei=堀口 kn-aut-mei=千景 aut-affil-num=12 ORCID= en-aut-name=FunakoshiAkihiro en-aut-sei=Funakoshi en-aut-mei=Akihiro kn-aut-name=船越顕博 kn-aut-sei=船越 kn-aut-mei=顕博 aut-affil-num=13 ORCID= en-aut-name=NishimoriHisakazu en-aut-sei=Nishimori en-aut-mei=Hisakazu kn-aut-name=西森久和 kn-aut-sei=西森 kn-aut-mei=久和 aut-affil-num=14 ORCID= en-aut-name=UchidaHaruhito Adam en-aut-sei=Uchida en-aut-mei=Haruhito Adam kn-aut-name=内田治仁 kn-aut-sei=内田 kn-aut-mei=治仁 aut-affil-num=15 ORCID= en-aut-name=OgawaDaisuke en-aut-sei=Ogawa en-aut-mei=Daisuke kn-aut-name=小川大輔 kn-aut-sei=小川 kn-aut-mei=大輔 aut-affil-num=16 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name=槇野博史 kn-aut-sei=槇野 kn-aut-mei=博史 aut-affil-num=17 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=3 en-affil= kn-affil=東京家政大学　栄養学科 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=12 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=13 en-affil= kn-affil=国立病院機構九州がんセンター　消化器肝胆膵内科 affil-num=14 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学 affil-num=15 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=16 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=17 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 en-keyword=cholecystokinin kn-keyword=cholecystokinin en-keyword=糖尿病性腎症 kn-keyword=糖尿病性腎症 en-keyword=抗炎症作用 kn-keyword=抗炎症作用 en-keyword=腎保護効果 kn-keyword=腎保護効果 END start-ver=1.4 cd-journal=joma no-vol=2012 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=2012 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=We previously reported that radon inhalation activates antioxidative functions in the liver and inhibits carbon tetrachloride-induced hepatopathy in mice. In addition, it has been reported that reactive oxygen species contribute to alcohol-induced hepatopathy. In this study, we examined the inhibitory effects of radon inhalation on acute alcohol- induced hepatopathy in mice. C57BL/6J mice were subjected to intraperitoneal injection of 50% alcohol (5 g/kg bodyweight) after inhaling approximately 4000 Bq/m(3) radon for 24 h. Alcohol administration significantly increased the activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) in serum, and the levels of triglyceride and lipid peroxide in the liver, suggesting acute alcohol- induced hepatopathy. Radon inhalation activated antioxidative functions in the liver. Furthermore, pretreatment with radon inhibited the depression of hepatic functions and antioxidative functions. These findings suggested that radon inhalation activated antioxidative functions in the liver and inhibited acute alcohol- induced hepatopathy in mice. en-copyright= kn-copyright= en-aut-name=ToyotaTeruaki en-aut-sei=Toyota en-aut-mei=Teruaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NishiyamaYuichi en-aut-sei=Nishiyama en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TaguchiTakehito en-aut-sei=Taguchi en-aut-mei=Takehito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Grad Sch Hlth Sci affil-num=2 en-affil= kn-affil=Okayama Univ, Grad Sch Hlth Sci affil-num=3 en-affil= kn-affil=Okayama Univ, Grad Sch Hlth Sci affil-num=4 en-affil= kn-affil=Okayama Univ, Grad Sch Hlth Sci affil-num=5 en-affil= kn-affil=Okayama Univ, Grad Sch Hlth Sci END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=3 article-no= start-page=239 end-page=242 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of appendiceal diverticulum resected by laparoscopic surgery with preoperative diagnosis of appendiceal tumor kn-title=虫垂腫瘍と術前診断し腹腔鏡下手術を行った虫垂仮性憩室症の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　Appendiceal diverticulum is rare. We encountered a case of appendiceal diverticulum with chronic appendicitis. A 56-year-old man presented to our hospital with right lower abdominal pain. An abdominal computed tomography (CT) scan showed swelling of the appendix body and the wall thickness of the base of the appendix. Due to the possibility of appendiceal tumor, we performed a laparoscopy-assisted ileocecal resection with lymph node dissection. The appendix had a diverticulum with chronic inflammation, but it did not have a neoplastic lesion. en-copyright= kn-copyright= en-aut-name=NinomiyaTakayuki en-aut-sei=Ninomiya en-aut-mei=Takayuki kn-aut-name=二宮卓之 kn-aut-sei=二宮 kn-aut-mei=卓之 aut-affil-num=1 ORCID= en-aut-name=OjimaYasutomo en-aut-sei=Ojima en-aut-mei=Yasutomo kn-aut-name=小島康知 kn-aut-sei=小島 kn-aut-mei=康知 aut-affil-num=2 ORCID= en-aut-name=HaranoMasao en-aut-sei=Harano en-aut-mei=Masao kn-aut-name=原野雅生 kn-aut-sei=原野 kn-aut-mei=雅生 aut-affil-num=3 ORCID= en-aut-name=OhnoSatoshi en-aut-sei=Ohno en-aut-mei=Satoshi kn-aut-name=大野聡 kn-aut-sei=大野 kn-aut-mei=聡 aut-affil-num=4 ORCID= en-aut-name=ShiozakiShigehiro en-aut-sei=Shiozaki en-aut-mei=Shigehiro kn-aut-name=塩崎滋弘 kn-aut-sei=塩崎 kn-aut-mei=滋弘 aut-affil-num=5 ORCID= en-aut-name=NinomiyaMotoki en-aut-sei=Ninomiya en-aut-mei=Motoki kn-aut-name=二宮基樹 kn-aut-sei=二宮 kn-aut-mei=基樹 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=2 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=3 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=4 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=5 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=6 en-affil= kn-affil=広島市立広島市民病院　外科 en-keyword=虫垂憩室症（appendiceal diverculum） kn-keyword=虫垂憩室症（appendiceal diverculum） en-keyword=腹腔鏡手術（laparoscopic surgery） kn-keyword=腹腔鏡手術（laparoscopic surgery） en-keyword=虫垂腫瘍（appendiceal tumor） kn-keyword=虫垂腫瘍（appendiceal tumor） END start-ver=1.4 cd-journal=joma no-vol=1 cd-vols= no-issue= article-no= start-page=27 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=個の考えを生かした量と測定の指導 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡正喜 kn-aut-sei=片岡 kn-aut-mei=正喜 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=総社市立昭和小学校 END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue= article-no= start-page=67 end-page=68 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20051029 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=今,算数教育に求められているもの en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡正喜 kn-aut-sei=片岡 kn-aut-mei=正喜 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=総社市教育委員会学校教育課 END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130124 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Chronic asthma is often associated with neutrophilic infiltration in the airways. Neutrophils contain elastase, a potent secretagogue in the airways, nonetheless the role for neutrophil elastase as well as neutrophilic inflammation in allergen-induced airway responses is not well defined. In this study, we have investigated the impact of neutrophil elastase inhibition on the development of allergic airway inflammation and airway hyperresponsiveness (AHR) in previously sensitized and challenged mice. Methods: BALB/c mice were sensitized and challenged (primary) with ovalbumin (OVA). Six weeks later, a single OVA aerosol (secondary challenge) was delivered and airway inflammation and airway responses were monitored 6 and 48 hrs later. An inhibitor of neutrophil elastase was administered prior to secondary challenge. Results: Mice developed a two-phase airway inflammatory response after secondary allergen challenge, one neutrophilic at 6 hr and the other eosinophilic, at 48 hr. PAR-2 expression in the lung tissues was enhanced following secondary challenge, and that PAR-2 intracellular expression on peribronchial lymph node (PBLN) T cells was also increased following allergen challenge of sensitized mice. Inhibition of neutrophil elastase significantly attenuated AHR, goblet cell metaplasia, and inflammatory cell accumulation in the airways following secondary OVA challenge. Levels of IL-4, IL-5 and IL-13, and eotaxin in BAL fluid 6 hr after secondary allergen challenge were significantly suppressed by the treatment. At 48 hr, treatment with the neutrophil elastase inhibitor significantly reduced the levels of IL-13 and TGF-beta 1 in the BAL fluid. In parallel, in vitro IL-13 production was significantly inhibited in spleen cells from sensitized mice. Conclusion: These data indicate that neutrophil elastase plays an important role in the development of allergic airway inflammation and hyperresponsiveness, and would suggest that the neutrophil elastase inhibitor reduced AHR to inhaled methacholine indicating the potential for its use as a modulator of the immune/inflammatory response in both the neutrophil-and eosinophil-dominant phases of the response to secondary allergen challenge. en-copyright= kn-copyright= en-aut-name=KogaHikari en-aut-sei=Koga en-aut-mei=Hikari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyaharaNobuaki en-aut-sei=Miyahara en-aut-mei=Nobuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FuchimotoYasuko en-aut-sei=Fuchimoto en-aut-mei=Yasuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IkedaGenyo en-aut-sei=Ikeda en-aut-mei=Genyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=WasedaKoichi en-aut-sei=Waseda en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OnoKatsuichiro en-aut-sei=Ono en-aut-mei=Katsuichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanimotoYasushi en-aut-sei=Tanimoto en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=GelfandErwin W. en-aut-sei=Gelfand en-aut-mei=Erwin W. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KanehiroArihiko en-aut-sei=Kanehiro en-aut-mei=Arihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Dept Hematol Oncol Allergy & Resp Med, Grad Sch Med Dent & Pharmaceut Sci affil-num=2 en-affil= kn-affil=Okayama Univ, Dept Hematol Oncol Allergy & Resp Med, Grad Sch Med Dent & Pharmaceut Sci affil-num=3 en-affil= kn-affil=Okayama Univ, Dept Hematol Oncol Allergy & Resp Med, Grad Sch Med Dent & Pharmaceut Sci affil-num=4 en-affil= kn-affil=Okayama Univ, Dept Hematol Oncol Allergy & Resp Med, Grad Sch Med Dent & Pharmaceut Sci affil-num=5 en-affil= kn-affil=Okayama Univ, Dept Hematol Oncol Allergy & Resp Med, Grad Sch Med Dent & Pharmaceut Sci affil-num=6 en-affil= kn-affil=Okayama Univ, Dept Hematol Oncol Allergy & Resp Med, Grad Sch Med Dent & Pharmaceut Sci affil-num=7 en-affil= kn-affil=Okayama Univ, Dept Hematol Oncol Allergy & Resp Med, Grad Sch Med Dent & Pharmaceut Sci affil-num=8 en-affil= kn-affil=Okayama Univ, Dept Hematol Oncol Allergy & Resp Med, Grad Sch Med Dent & Pharmaceut Sci affil-num=9 en-affil= kn-affil=Natl Jewish Hlth, Dept Pediat, Div Cell Biol affil-num=10 en-affil= kn-affil=Okayama Univ, Dept Hematol Oncol Allergy & Resp Med, Grad Sch Med Dent & Pharmaceut Sci affil-num=11 en-affil= kn-affil=Okayama Univ, Dept Hematol Oncol Allergy & Resp Med, Grad Sch Med Dent & Pharmaceut Sci en-keyword=Neutrophil kn-keyword=Neutrophil en-keyword=Elastase kn-keyword=Elastase en-keyword=Airway kn-keyword=Airway en-keyword=Hyperresponsiveness kn-keyword=Hyperresponsiveness en-keyword=Asthma kn-keyword=Asthma END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=6 article-no= start-page=830 end-page=839 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Comparative study on the inhibitory effects of antioxidant vitamins and radon on carbon tetrachloride-induced hepatopathy en-subtitle= kn-subtitle= en-abstract= kn-abstract=We have previously reported that radon inhalation activates anti-oxidative functions and inhibits carbon tetrachloride (CCl(4))-induced hepatopathy. It has also been reported that antioxidant vitamins can inhibit CCl(4)-induced hepatopathy. In the current study, we examined the comparative efficacy of treatment with radon, ascorbic acid and α-tocopherol on CCl(4)-induced hepatopathy. Mice were subjected to intraperitoneal injection of CCl(4) after inhaling approximately 1000 or 2000 Bq/m(3) radon for 24 h, or immediately after intraperitoneal injection of ascorbic acid (100, 300, or 500 mg/kg bodyweight) or α-tocopherol (100, 300, or 500 mg/kg bodyweight). We estimated the inhibitory effects on CCl(4)-induced hepatopathy based on hepatic function-associated parameters, oxidative damage-associated parameters and histological changes. The results revealed that the therapeutic effects of radon inhalation were almost equivalent to treatment with ascorbic acid at a dose of 500 mg/kg or α-tocopherol at a dose of 300 mg/kg. The activities of superoxide dismutase, catalase, and glutathione peroxidase in the liver were significantly higher in mice exposed to radon than in mice treated with CCl(4) alone. These findings suggest that radon inhalation has an anti-oxidative effect against CCl(4)-induced hepatopathy similar to the anti-oxidative effects of ascorbic acid or α-tocopherol due to the induction of anti-oxidative functions. en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishiyamaYuichi en-aut-sei=Nishiyama en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamatoKeiko en-aut-sei=Yamato en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TeraokaJunichi en-aut-sei=Teraoka en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MoriiYuji en-aut-sei=Morii en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IshimoriYuu en-aut-sei=Ishimori en-aut-mei=Yuu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TaguchiTakehito en-aut-sei=Taguchi en-aut-mei=Takehito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=6 en-affil= kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency affil-num=7 en-affil= kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency affil-num=8 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=9 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University en-keyword=Radon kn-keyword=Radon en-keyword=ascorbic acid kn-keyword=ascorbic acid en-keyword=α-tocopherol kn-keyword=α-tocopherol en-keyword=antioxidant kn-keyword=antioxidant en-keyword=hepatopathy kn-keyword=hepatopathy END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=5 article-no= start-page=387 end-page=397 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=201210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Detection of Torque Teno Virus DNA in Exhaled Breath by Polymerase Chain Reaction en-subtitle= kn-subtitle= en-abstract= kn-abstract=To determine whether exhaled breath contains Torque teno virus (TTV) or not, we tested exhaled breath condensate (EBC) samples by semi-nested PCR assay. We detected TTV DNA in 35% (7/20) of EBC samples collected from the mouth of one of the authors, demonstrating that TTV DNA is excreted in exhaled breath with moderate frequency. TTV DNA was detected also in oral EBC samples from 4 of 6 other authors, indicating that TTV DNA excretion in exhaled breath is not an exception but rather a common phenomenon. Furthermore, the same assay could amplify TTV DNA from room air condensate (RAC) samples collected at distances of 20 and 40cm from a human face with 40 (8/20) and 35% (7/20) positive rates, respectively. TTV transmission has been reported to occur during infancy. These distances seem equivalent to that between an infant and its household members while caring for the infant. Taken together, it seems that exhaled breath is one of the possible transmission routes of TTV. We also detected TTV DNA in 25% (10/40) of RAC samples collected at a distance of more than 180cm from any human face, suggesting the risk of airborne infection with TTV in a room. en-copyright= kn-copyright= en-aut-name=ChikasueKumiko en-aut-sei=Chikasue en-aut-mei=Kumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KimuraMiyuki en-aut-sei=Kimura en-aut-mei=Miyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IkedaKazuyuki en-aut-sei=Ikeda en-aut-mei=Kazuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhnishiTakuma en-aut-sei=Ohnishi en-aut-mei=Takuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KawanishiSatoshi en-aut-sei=Kawanishi en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IioTomoe en-aut-sei=Iio en-aut-mei=Tomoe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=AraoYujiro en-aut-sei=Arao en-aut-mei=Yujiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=4 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=5 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=6 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=7 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=8 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University en-keyword=Torque teno virus kn-keyword=Torque teno virus en-keyword=exhaled breath kn-keyword=exhaled breath en-keyword=airborne infection kn-keyword=airborne infection en-keyword=polymerase chain reaction kn-keyword=polymerase chain reaction END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue=9 article-no= start-page=1181 end-page=1187 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=201210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Comparative Study on the Inhibitory Effects of α-Tocopherol and Radon on Carbon Tetrachloride-Induced Renal Damage en-subtitle= kn-subtitle= en-abstract= kn-abstract=Since the 2011 nuclear accident in Fukushima, the effects of low-dose irradiation, especially internal exposure, are at the forefront of everyone’s attention. However, low-dose radiation induced various stimulating effects such as activation of antioxidative and immune functions. In this study, we attempted to evaluate the quantitative effects of the activation of antioxidative activities in kidney induced by radon inhalation on carbon tetrachloride (CCl4)-induced renal damage. Mice were subjected to intraperitoneal (i.p.) injection of CCl4 after inhaling approximately 1000 or 2000 Bq/m3 radon for 24 h, or immediately after i.p. injection of α-tocopherol (100, 300, or 500 mg/kg bodyweight). In case of renal function, radon inhalation at a concentration of 2000 Bq/m3 has the inhibitory effects similar to α-tocopherol treatment at a dose of 300–500 mg/kg bodyweight. The activities of superoxide dismutase and catalase in kidneys were significantly higher in mice exposed to radon as compared to mice treated with CCl4 alone. These findings suggest that radon inhalation has an antioxidative effect against CCl4-induced renal damage similar to the antioxidative effects of α-tocopherol due to induction of antioxidative functions. en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamatoKeiko en-aut-sei=Yamato en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NishiyamaYuichi en-aut-sei=Nishiyama en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoriiYuji en-aut-sei=Morii en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=EtaniReo en-aut-sei=Etani en-aut-mei=Reo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakataYuji en-aut-sei=Takata en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HanamotoKatsumi en-aut-sei=Hanamoto en-aut-mei=Katsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KawabeAtsuishi en-aut-sei=Kawabe en-aut-mei=Atsuishi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IshimoriYuu en-aut-sei=Ishimori en-aut-mei=Yuu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TaguchiTakehito en-aut-sei=Taguchi en-aut-mei=Takehito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=6 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=7 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=8 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=9 en-affil= kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency affil-num=10 en-affil= kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency affil-num=11 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=12 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University en-keyword=radon kn-keyword=radon en-keyword=carbon tetrachloride kn-keyword=carbon tetrachloride en-keyword=oxidative damage kn-keyword=oxidative damage en-keyword=α-tocopherol kn-keyword=α-tocopherol en-keyword=kidney kn-keyword=kidney END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=1 article-no= start-page=1 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120127 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Basic Study on Positive Effects of Radon Inhalation on Pet's Health kn-title=ラドン吸入がペットの健康改善に及ぼす効果に関する基礎的検討 en-subtitle= kn-subtitle= en-abstract=Radon inhalation using our radon exposure device activated anti-oxidative function in some organs of mouse. To assess the possibility of its application to veterinary care, healthy dogs and cats with chronic renal failure were inhaled radon at a concentration of 5500Bq/m3 for 30 minutes every 2 days for 30 days. In result, radon inhalation within a relatively long time period significantly decreased the triglyceride level of dogs. On the other hand, some cats increased the volume of drinking water by radon inhalation and the creatinine level in blood of these cats was decreased to normal level. These findings suggest that radon inhalation may have curative properties against chronic renal failure. kn-abstract=著者らは今までに，共同開発したラドン吸入装置を用いマウスにラドン吸入をさせた場合，諸臓器中の抗酸化機能が亢進する可能性などを明らかにしてきた。本研究では，ラドン吸入の獣医療への応用の可能性について新たに検討するため，健常なイヌ5頭(オス：2(1，9才)，メス：3(1～5才))及び慢性腎不全症のネコ8頭(オス：3(2～6才)，メス：5(5～7才))を対象に基礎的な検討をした。すなわち，約5500Bq/m3のラドンを1回30分で隔日に30日間(計15回)それぞれ吸入させた。その結果，イヌにおいて，中性脂肪が減少する可能性が示された。また，その効果は吸入開始20～30日後に現れることも示唆できた。他方，ネコにおいて，飲水量が改善し血清中クレアチニンが基準値内に減少する症例がみられるなど，慢性腎不全症に対し一定の効果が期待できる可能性が示唆された。 en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name=片岡隆浩 kn-aut-sei=片岡 kn-aut-mei=隆浩 aut-affil-num=1 ORCID= en-aut-name=TokunagaRikizo en-aut-sei=Tokunaga en-aut-mei=Rikizo kn-aut-name=徳永力三 kn-aut-sei=徳永 kn-aut-mei=力三 aut-affil-num=2 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name=迫田晃弘 kn-aut-sei=迫田 kn-aut-mei=晃弘 aut-affil-num=3 ORCID= en-aut-name=KawabeAtsushi en-aut-sei=Kawabe en-aut-mei=Atsushi kn-aut-name=川辺睦 kn-aut-sei=川辺 kn-aut-mei=睦 aut-affil-num=4 ORCID= en-aut-name=HanamotoKatsumi en-aut-sei=Hanamoto en-aut-mei=Katsumi kn-aut-name=花元克巳 kn-aut-sei=花元 kn-aut-mei=克巳 aut-affil-num=5 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name=山岡聖典 kn-aut-sei=山岡 kn-aut-mei=聖典 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=2 en-affil= kn-affil=南富士ケンネル附属動物病院 affil-num=3 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=4 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=5 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=6 en-affil= kn-affil=岡山大学大学院保健学研究科 en-keyword=dog kn-keyword=dog en-keyword=cat kn-keyword=cat en-keyword=radon inhalation kn-keyword=radon inhalation en-keyword=serum biochemistry kn-keyword=serum biochemistry en-keyword=chronic renal failure kn-keyword=chronic renal failure END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=4 article-no= start-page=241 end-page=251 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080425 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Basic Study on Activation of Antioxidation Function in Some Organs of Mice by Radon Inhalation Using New Radon Exposure Device kn-title=ラドン吸入試作装置によるマウス諸臓器中の抗酸化機能の亢進に関する研究 en-subtitle= kn-subtitle= en-abstract=There are a lot of life style diseases that are related to reactive oxygen species in indications of the radon therapy, and, the further clarification of mechanism is expected. Therefore, in this study, we investigated the activation of antioxidation function in some organs of mice by radon inhalation using the new radon exposure device. It was enable that this device was the adjustments of radon concentration by changing the air flow rate to the specially processed radon source and so on. The mice were made to inhale the radon of 400Bq/m3 or 4000Bq/m3 with this device. Results show that in brain, lungs, liver, and kidney, both the activities of superoxide dismutase(SOD) and catalase increased, and lipid peroxide levels decreased. This suggests that radon inhalation enhanced the antioxidation function. These findings are important in understanding the mechanism of diseases in which radon therapy is used as treatment, and most of which are called activated oxygen-related diseases. kn-abstract=ラドン療法の適応症には活性酸素に由来する生活習慣病が多く，その機構の更なる解明が期待されている。また，汎用性があり医学的効果が再現できるラドン吸入装置の構築は意義が大きい。このため，著者らは共同で開発したラドン吸入試作装置を用い，マウス諸臓器中の抗酸化機能の変化特性を検討した。ラドン吸入試作装置は，特殊加工したラドン線源を収納したユニットの数量，それへの送風量及び湿度などを調節することによりラドン濃度を自在に調整可能にするものである。この装置によりマウスに400Bq/m3あるいは4000Bq/m3のラドンを吸入させた。その結果，脳・肺・肝臓・腎臓において，抗酸化系酵素であるSODとカタラーゼの両活性が増加し，過酸化脂質量が減少した。この抗酸化機能の亢進により，本実験条件でのラドン吸入は活性酸素障害の抑制，すなわち，生活習慣病の予防や症状緩和に効果のある可能性が改めて示唆できた。 en-copyright= kn-copyright= en-aut-name=NakagawaShinya en-aut-sei=Nakagawa en-aut-mei=Shinya kn-aut-name=中川慎也 kn-aut-sei=中川 kn-aut-mei=慎也 aut-affil-num=1 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name=片岡隆浩 kn-aut-sei=片岡 kn-aut-mei=隆浩 aut-affil-num=2 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name=迫田晃弘 kn-aut-sei=迫田 kn-aut-mei=晃弘 aut-affil-num=3 ORCID= en-aut-name=IshimoriYuu en-aut-sei=Ishimori en-aut-mei=Yuu kn-aut-name=石森有 kn-aut-sei=石森 kn-aut-mei=有 aut-affil-num=4 ORCID= en-aut-name=HanamotoKatsumi en-aut-sei=Hanamoto en-aut-mei=Katsumi kn-aut-name=花元克巳 kn-aut-sei=花元 kn-aut-mei=克巳 aut-affil-num=5 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name=山岡聖典 kn-aut-sei=山岡 kn-aut-mei=聖典 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=2 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=3 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=4 en-affil= kn-affil=独立行政法人　日本原子力研究開発機構人形峠環境技術センター affil-num=5 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=6 en-affil= kn-affil=岡山大学大学院保健学研究科 en-keyword=new radon exposure device kn-keyword=new radon exposure device en-keyword=radon inhalation kn-keyword=radon inhalation en-keyword=antioxidative function kn-keyword=antioxidative function en-keyword=superoxide dismutase kn-keyword=superoxide dismutase en-keyword=catalase kn-keyword=catalase en-keyword=lipid peroxide kn-keyword=lipid peroxide en-keyword=active oxygen kn-keyword=active oxygen en-keyword=mouse kn-keyword=mouse en-keyword=radon-222 kn-keyword=radon-222 END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=5 article-no= start-page=231 end-page=241 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120529 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Inhibitory Effects of Pre and Post Radon Inhalation on Carbon Tetrachloride-induced Oxidative Damage in Mouse Organs en-subtitle= kn-subtitle= en-abstract= kn-abstract=Radon inhalation activates antioxidative functions in some organs of mice. We examined the prevention effects of pre radon inhalation and the alleviation effects of post radon inhalation on carbon tetrachloride (CCl4)-induced oxidative damage in the brain, heart, lung, liver, and kidney of mice. In addition, we compared the effect of pre and post radon inhalation on oxidative damage. Mice inhaled radon at a concentration of 18000Bq/m3 for 6hrs before or after CCl4 administration. As a result, the total glutathione(t-GSH) contents and catalase(CAT) activities in the brain, heart, lung, liver, and kidney and superoxide dismutase(SOD) activities in the heart and lung were significantly higher in pre and post radon-inhaled mice than in mice treated with only CCl4. Pre radon inhalation inhibited and post radon inhalation reduced lipid peroxidation induced by CCl4. In addition, there were no significant differences in lipid peroxide(LPO) levels in the brain, heart, lung, liver, and kidney between pre and post radon-inhaled mice. These findings suggested that post radon inhalation has the same effects as pre radon inhalation against CCl4-induced oxidative damage in the brain, heart, lung, liver, and kidney. en-copyright= kn-copyright= en-aut-name=NishiyamaYuichi en-aut-sei=Nishiyama en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TeraokaJunichi en-aut-sei=Teraoka en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IshimoriYuu en-aut-sei=Ishimori en-aut-mei=Yuu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=4 en-affil= kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency affil-num=5 en-affil= kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency affil-num=6 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University en-keyword=carbon tetrachloride kn-keyword=carbon tetrachloride en-keyword=oxidative damage kn-keyword=oxidative damage en-keyword=pre or post radon inhalation kn-keyword=pre or post radon inhalation en-keyword=antioxidative function kn-keyword=antioxidative function END start-ver=1.4 cd-journal=joma no-vol=146 cd-vols= no-issue=1-3 article-no= start-page=360 end-page=363 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=201107 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Studies on possibility for alleviation of lifestyle diseases by low-dose irradiation or radon inhalation en-subtitle= kn-subtitle= en-abstract= kn-abstract=Our previous studies showed the possibility that activation of the antioxidative function alleviates various oxidative damages, which are related to lifestyle diseases. Results showed that, low-dose X-ray irradiation activated superoxide dismutase and inhibits oedema following ischaemia-reperfusion. To alleviate ischaemia-reperfusion injury with transplantation, the changes of the antioxidative function in liver graft using low-dose X-ray irradiation immediately after exenteration were examined. Results showed that liver grafts activate the antioxidative function as a result of irradiation. In addition, radon inhalation enhances the antioxidative function in some organs, and alleviates alcohol-induced oxidative damage of mouse liver. Moreover, in order to determine the most effective condition of radon inhalation, mice inhaled radon before or after carbon tetrachloride (CCl4) administration. Results showed that radon inhalation alleviates CCl4-induced hepatopathy, especially prior inhalation. It is highly possible that adequate activation of antioxidative functions induced by low-dose irradiation can contribute to preventing or reducing oxidative damages, which are related to lifestyle diseases. en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YoshimotoMasaaki en-aut-sei=Yoshimoto en-aut-mei=Masaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakagawaShinya en-aut-sei=Nakagawa en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ToyotaTeruaki en-aut-sei=Toyota en-aut-mei=Teruaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NishiyamaYuichi en-aut-sei=Nishiyama en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamatoKeiko en-aut-sei=Yamato en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IshimoriYuu en-aut-sei=Ishimori en-aut-mei=Yuu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KawabeAtsushi en-aut-sei=Kawabe en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HanamotoKatsumi en-aut-sei=Hanamoto en-aut-mei=Katsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TaguchiTakehito en-aut-sei=Taguchi en-aut-mei=Takehito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=4 en-affil= kn-affil=Sakakibara Heart Institute of Okayama affil-num=5 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=6 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=7 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=8 en-affil= kn-affil=Ningyo-toge Environmental Engineering Center affil-num=9 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=10 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=11 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=12 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=2 article-no= start-page=219 end-page=226 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=200909 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Basic Study on Active Changes in Biological Function of Mouse Liver Graft in Cold Storage after Low-Dose X-Irradiation en-subtitle= kn-subtitle= en-abstract= kn-abstract=We previously reported that low-dose X-irradiation alleviates ischemia-reperfusion injury such as mouse paw edema. In this study, we examined active changes in the biological function of mouse liver grafts in cold storage after low-dose X-irradiation. Mouse livers were sham-irradiated or were irradiated with 0.25, 0.5, 1.0, or 5.0 Gy of X-ray and stored for 4, 8, 24, or 48 h in preservation or saline solution. The results show that storage for 24 h in saline solution after 0.5 Gy irradiation significantly increased the activity of superoxide dismutase (SOD) and catalase. Following storage for 4, 8, or 48 h in preservation solution, lipid peroxide levels of the 0.5 Gy irradiated group were significantly lower than those of the sham irradiated group. Following storage for 24 h in preservation solution, the activity of SOD and catalase of the 1.0 Gy irradiated group were significantly higher than those of the sham irradiated group. Hepatocytes stored in saline solution were vacuolated. However, no vacuole formation was observed in hepatocytes stored in preservation solution. These findings suggest that low-dose irradiation significantly activates antioxidative functions of liver grafts. Moreover, the dose at which enhancement of antioxidative function occurs in livers stored in preservation solution, which contains glutathione, is significantly higher than that in saline solution. en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YoshimotoMasaaki en-aut-sei=Yoshimoto en-aut-mei=Masaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakagawaShinya en-aut-sei=Nakagawa en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MizuguchiYuko en-aut-sei=Mizuguchi en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TaguchiTakehito en-aut-sei=Taguchi en-aut-mei=Takehito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=4 en-affil= kn-affil=Radiation Safety Research Center, Central Research Institute of Electric Power Industry affil-num=5 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=6 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University en-keyword=organ transplantation kn-keyword=organ transplantation en-keyword=low-dose irradiation kn-keyword=low-dose irradiation en-keyword=antioxidative function kn-keyword=antioxidative function en-keyword=hepatopathy kn-keyword=hepatopathy END start-ver=1.4 cd-journal=joma no-vol=43 cd-vols= no-issue=1 article-no= start-page=41 end-page=49 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200807 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=No Different Sensitivity in Terms of Whole-Body Irradiation between Normal and Acatalasemic Mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=To elucidate the radiosensitivity of an acatalasemic mouse, we examined the time and dose-dependency in the survival rates, the lymphocytes and the intestinal epithelial cells, and the antioxidant function after 3.0 to 12.0 Gy whole body irradiation. Results showed that no significant differences between acatalasemic mice and normal mice were observed in the survival rates and the histological changes in spleens and small intestine after each irradiation. The catalase activities in livers and spleens of acatalasemic mice were significantly lower than those of normal mice and the glutathione peroxidase activity in livers of acatalasemic mice was significantly higher than that of normal mice. At 10 days after 6.0 Gy irradiation, the catalase activities in livers of acatalasemic and normal mice and that in spleens of normal mice significantly decreased compared with no-irradiation control, and there were no differences between those catalase activities. The total glutathione content in acatalasemic mice was significantly higher than that in normal mice at 10 days after 6.0 Gy irradiation. These findings suggested that the radiosensitivity of acatalasemic mice in terms of whole body irradiation doesn’t significantly differ from that of normal mice, probably due to compensated sufficient contents of glutathione peroxidase and total glutathione in acatalasemic mice. en-copyright= kn-copyright= en-aut-name=NakagawaShinya en-aut-sei=Nakagawa en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MizuguchiYuko en-aut-sei=Mizuguchi en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YoshimotoMasaaki en-aut-sei=Yoshimoto en-aut-mei=Masaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NomuraTakaharu en-aut-sei=Nomura en-aut-mei=Takaharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=WangDa-Hong en-aut-sei=Wang en-aut-mei=Da-Hong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KawabeAtsushi en-aut-sei=Kawabe en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TaguchiTakehito en-aut-sei=Taguchi en-aut-mei=Takehito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=6 en-affil= kn-affil=Radiation Safety Research Center, Central Research Institute of Electric Power Industry affil-num=7 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=8 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=9 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=10 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University en-keyword=acatalasemic mouse kn-keyword=acatalasemic mouse en-keyword=radiosensitivity kn-keyword=radiosensitivity en-keyword=catalase kn-keyword=catalase en-keyword=glutathione peroxidase kn-keyword=glutathione peroxidase en-keyword=total glutathione kn-keyword=total glutathione END start-ver=1.4 cd-journal=joma no-vol=2012 cd-vols= no-issue= article-no= start-page=11 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120209 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Activation of Biodefense System by Low-Dose Irradiation or Radon Inhalation and Its Applicable Possibility for Treatment of Diabetes and Hepatopathy en-subtitle= kn-subtitle= en-abstract= kn-abstract=Adequate oxygen stress induced by low-dose irradiation activates biodefense system, such as induction of the synthesis of superoxide dismutase (SOD) and glutathione peroxidase. We studied the possibility for alleviation of oxidative damage, such as diabetes and nonalcoholic liver disease. Results show that low-dose γ-irradiation increases SOD activity and protects against alloxan diabetes. Prior or post-low-dose X- or γ-irradiation increases antioxidative functions in livers and inhibits ferric nitrilotriacetate and carbon tetrachloride-induced (CCl4) hepatopathy. Moreover, radon inhalation also inhibits CCl4-induced hepatopathy. It is highly possible that low-dose irradiation including radon inhalation activates the biodefence systems and, therefore, contributes to preventing or reducing reactive oxygen species-related diabetes and nonalcoholic liver disease, which are thought to involve peroxidation. en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University END start-ver=1.4 cd-journal=joma no-vol=48 cd-vols= no-issue=6 article-no= start-page=505 end-page=513 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20071121 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Inhibitory Effects of Prior Low-dose X-irradiation on Ischemia-reperfusion Injury in Mouse Paw en-subtitle= kn-subtitle= en-abstract= kn-abstract=We have reported that low-dose, unlike high-dose, irradiation enhanced antioxidation function and reduced oxidative damage. On the other hand, ischemia-reperfusion injury is induced by reactive oxygen species. In this study, we examined the inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw. BALB/c mice were irradiated by sham or 0.5 Gy of X-ray. At 4 hrs after irradiation, the left hind leg was bound 10 times with a rubber ring for 0.5, 1, or 2 hrs and the paw thickness was measured. Results show that the paw swelling thickness by ischemia for 0.5 hr was lower than that for 2 hrs. At 1 hr after reperfusion from ischemia for 1 hr, superoxide dismutase activity in serum was increased in those mice which received 0.5 Gy irradiation and in the case of the ischemia for 0.5 or 1 hr, the paw swelling thicknesses were inhibited by 0.5 Gy irradiation. In addition, interstitial edema in those mice which received 0.5 Gy irradiation was less than that in the mice which underwent by sham irradiation. These findings suggest that the ischemia-reperfusion injury is inhibited by the enhancement of antioxidation function by 0.5 Gy irradiation. en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MizuguchiYuko en-aut-sei=Mizuguchi en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YoshimotoMasaaki en-aut-sei=Yoshimoto en-aut-mei=Masaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TaguchiTakehito en-aut-sei=Taguchi en-aut-mei=Takehito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University en-keyword=Edema kn-keyword=Edema en-keyword=Ischemia-reperfusion injury kn-keyword=Ischemia-reperfusion injury en-keyword=Low-dose irradiation kn-keyword=Low-dose irradiation en-keyword=Reactive oxygen species kn-keyword=Reactive oxygen species en-keyword=Antioxidation function kn-keyword=Antioxidation function END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue=1 article-no= start-page=21 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Elevation of p53 Protein Level and SOD Activity in the Resident Blood of the Misasa Radon Hot Spring District en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the mechanism by which radon hot springs prevent cancer or not, in this study, blood was collected from residents in the Misasa hot spring district and in a control district. The level of a representative cancer-suppressive gene, p53, and the activity of a representative antioxidant enzyme, superoxide dismutase (SOD), were analyzed as indices. The level of serum p53 protein in the males in the Misasa hot spring district was found to be 2-fold higher than that in the control district, which is a significant difference. In the females in the Misasa hot spring district, SOD activity was approximately 15% higher than that in the control district, which is also statistically significant, and exceeded the reference range of SOD activity despite advanced age. These results suggested that routine exposure of the residents in the Misasa hot spring district to radon at a concentration about 3 times higher than the national mean induces trace active oxygen in vivo, potentiating products of cancer-suppressive gene and antioxidant function. As the p53 protein level was high in the residents in the Misasa hot spring district, apoptosis of cancer cells may readily occur. en-copyright= kn-copyright= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KojimaShuji en-aut-sei=Kojima en-aut-mei=Shuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShibakuraMisako en-aut-sei=Shibakura en-aut-mei=Misako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HanamotoKatsumi en-aut-sei=Hanamoto en-aut-mei=Katsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Departments of Radiological Technology, Okayama University Medical School affil-num=2 en-affil= kn-affil=Misasa Medical Center, Okayama University Medical School affil-num=3 en-affil= kn-affil=Faculty of Pharmaceutical Sciences, Science University of Tokyo affil-num=4 en-affil= kn-affil=Departments of Medical Technology, Okayama University Medical School affil-num=5 en-affil= kn-affil=Departments of Radiological Technology, Okayama University Medical School affil-num=6 en-affil= kn-affil=Departments of Radiological Technology, Okayama University Medical School affil-num=7 en-affil= kn-affil=Misasa Medical Center, Okayama University Medical School en-keyword=Radon hot spring kn-keyword=Radon hot spring en-keyword=Misasa kn-keyword=Misasa en-keyword=Cancer-related mortality rate kn-keyword=Cancer-related mortality rate en-keyword=p53 protein level kn-keyword=p53 protein level en-keyword=Superoxide dismutase activity kn-keyword=Superoxide dismutase activity END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=1 article-no= start-page=89 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040507 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Inhibitory Effects of Prior Low-dose X-ray Irradiation on Carbon Tetrachloride-induced Hepatopathy in Acatalasemic Mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=The catalase activities in blood and organs of the acatalasemic (C3H/AnLCsbCsb) mouse of C3H strain are lower than those of the normal (C3H/AnLCsaCsa) mouse. We examined the effects of prior low-dose (0.5 Gy) X-ray irradiation, which reduced the oxidative damage under carbon tetrachloride-induced hepatopathy in the acatalasemic or normal mice. The acatalasemic mice showed a significantly lower catalase activity and a significantly higher glutathione peroxidase activity compared with those in the normal mice. Moreover, low-dose irradiation increased the catalase activity in the acatalasemic mouse liver to a level similar to that of the normal mouse liver. Pathological examinations and analyses of blood glutamic oxaloacetic and glutamic pyruvic transaminase activity and lipid peroxide levels showed that carbon tetrachloride induced hepatopathy was inhibited by low-dose irradiation. These findings may indicate that the free radical reaction induced by the lack of catalase and the administration of carbon tetrachloride is more properly neutralized by high glutathione peroxidase activity and low-dose irradiation in the acatalasemic mouse liver. en-copyright= kn-copyright= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NomuraTakaharu en-aut-sei=Nomura en-aut-mei=Takaharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TaguchiTakehito en-aut-sei=Taguchi en-aut-mei=Takehito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=WangDa-Hong en-aut-sei=Wang en-aut-mei=Da-Hong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MoriShuji en-aut-sei=Mori en-aut-mei=Shuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HanamotoKatsumi en-aut-sei=Hanamoto en-aut-mei=Katsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KiraShohei en-aut-sei=Kira en-aut-mei=Shohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School affil-num=2 en-affil= kn-affil=Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School affil-num=3 en-affil= kn-affil=Low Dose Radiation Research Center, Central Research Institute of Electric Power Industry affil-num=4 en-affil= kn-affil=Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School affil-num=5 en-affil= kn-affil=Public Health, Okayama University Medical School affil-num=6 en-affil= kn-affil=Pharmacology, Okayama University Medical School affil-num=7 en-affil= kn-affil=Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School affil-num=8 en-affil= kn-affil=Public Health, Okayama University Medical School en-keyword=Acatalasemic mouse kn-keyword=Acatalasemic mouse en-keyword=Catalase kn-keyword=Catalase en-keyword=CCl4 kn-keyword=CCl4 en-keyword=Hepatotoxicity kn-keyword=Hepatotoxicity en-keyword=Low-dose X-irradiation kn-keyword=Low-dose X-irradiation en-keyword=Antioxidant substances kn-keyword=Antioxidant substances END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=6 article-no= start-page=775 end-page=781 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111122 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Study of the Response of Superoxide Dismutase in Mouse Organs to Radon Using a New Large-scale Facility for Exposing Small Animals to Radon en-subtitle= kn-subtitle= en-abstract= kn-abstract=We examined dose–dependent or dose rate–dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m3 for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2000 day•Bq/m3, activation of SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose–rate effects. Our results also suggested that continuous exposure to radon increased SOD activity, but SOD activity transiently returned to normal levels at around 2 days. Moreover, we classified the organs into four groups (1. plasma, brain, lung; 2. heart, liver, pancreas, small intestine; 3. kidney, thymus; 4. stomach) based on changes in SOD activity. Thymus had the highest responsiveness and stomach had lowest. These data provide useful baseline measurements for future studies on radon effects. en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IshimoriYuu en-aut-sei=Ishimori en-aut-mei=Yuu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ToyotaTeruaki en-aut-sei=Toyota en-aut-mei=Teruaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NishiyamaYuichi en-aut-sei=Nishiyama en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TanakaHiroshi en-aut-sei=Tanaka en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency affil-num=4 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=6 en-affil= kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency affil-num=7 en-affil= kn-affil=Misasa Medical Center, Okayama University Hospital affil-num=8 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University en-keyword=Radon kn-keyword=Radon en-keyword=Superoxide dismutase kn-keyword=Superoxide dismutase en-keyword=Dose kn-keyword=Dose en-keyword=Dose rate kn-keyword=Dose rate en-keyword=Large-scale facility kn-keyword=Large-scale facility END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=2 article-no= start-page=713 end-page=722 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Protective Effects of Radon Inhalation on Carrageenan-Induced Inflammatory Paw Edema in Mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=We assessed whether radon inhalation inhibited carrageenan-induced inflammation in mice. Carrageenan (1% v/v) was injected subcutaneously into paws of mice that had or had not inhaled approximately 2,000 Bq/m3 of radon for 24 h. Radon inhalation significantly increased superoxide dismutase (SOD) and catalase activities and significantly decreased lipid peroxide levels in mouse paws, indicating that radon inhalation activates antioxidative functions. Carrageenan administration induced paw edema and significantly increased tumor necrosis factor-alpha (TNF-α) and nitric oxide in serum. However, radon inhalation significantly reduced carrageenan-induced paw edema. Serum TNF-α levels were lower in the radon-treated mice than in sham-treated mice. In addition, SOD and catalase activities in paws were significantly higher in the radon-treated mice than in the sham-treated mice. These findings indicated that radon inhalation had anti-inflammatory effects and inhibited carrageenan-induced inflammatory paw edema. en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TeraokaJunichi en-aut-sei=Teraoka en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NishiyamaYuichi en-aut-sei=Nishiyama en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamatoKeiko en-aut-sei=Yamato en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MondenMayuko en-aut-sei=Monden en-aut-mei=Mayuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IshimoriYuu en-aut-sei=Ishimori en-aut-mei=Yuu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NomuraTakaharu en-aut-sei=Nomura en-aut-mei=Takaharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TaguchiTakehito en-aut-sei=Taguchi en-aut-mei=Takehito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency affil-num=4 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=6 en-affil= kn-affil=Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University affil-num=7 en-affil= kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency affil-num=8 en-affil= kn-affil=Radiation Safety Research Center, Central Research Institute of Electric Power Industry affil-num=9 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=10 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University en-keyword=radon inhalation kn-keyword=radon inhalation en-keyword=inflammation kn-keyword=inflammation en-keyword=carrageenan kn-keyword=carrageenan en-keyword=edema kn-keyword=edema en-keyword=antioxidative function kn-keyword=antioxidative function END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue=6 article-no= start-page=559 end-page=567 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishiyamaYuichi en-aut-sei=Nishiyama en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ToyotaTeruaki en-aut-sei=Toyota en-aut-mei=Teruaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YoshimotoMasaaki en-aut-sei=Yoshimoto en-aut-mei=Masaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IshimoriYuu en-aut-sei=Ishimori en-aut-mei=Yuu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AoyamaYutaka en-aut-sei=Aoyama en-aut-mei=Yutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TaguchiTakehito en-aut-sei=Taguchi en-aut-mei=Takehito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=6 en-affil= kn-affil=Ningyo-toge Environmental Engineering Center affil-num=7 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=8 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=9 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University en-keyword=radon inhalation kn-keyword=radon inhalation en-keyword=ascorbic acid kn-keyword=ascorbic acid en-keyword=carbon tetrachloride kn-keyword=carbon tetrachloride en-keyword=antioxidative function kn-keyword=antioxidative function en-keyword=liver kn-keyword=liver END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=2 article-no= start-page=155 end-page=159 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Approaches for infantile hearing loss：Transmission from Okayama to other prefectures kn-title=小児難聴に対する取り組み―岡山から全国への発信― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaYuko en-aut-sei=Kataoka en-aut-mei=Yuko kn-aut-name=片岡祐子 kn-aut-sei=片岡 kn-aut-mei=祐子 aut-affil-num=1 ORCID= en-aut-name=FukushimaKunihiro en-aut-sei=Fukushima en-aut-mei=Kunihiro kn-aut-name=福島邦博 kn-aut-sei=福島 kn-aut-mei=邦博 aut-affil-num=2 ORCID= en-aut-name=SugayaAkiko en-aut-sei=Sugaya en-aut-mei=Akiko kn-aut-name=菅谷明子 kn-aut-sei=菅谷 kn-aut-mei=明子 aut-affil-num=3 ORCID= en-aut-name=NishizakiKazunori en-aut-sei=Nishizaki en-aut-mei=Kazunori kn-aut-name=西﨑和則 kn-aut-sei=西﨑 kn-aut-mei=和則 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　耳鼻咽喉・頭頸部外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　耳鼻咽喉・頭頸部外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　耳鼻咽喉・頭頸部外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　耳鼻咽喉・頭頸部外科学 en-keyword=新生児聴覚スクリーニング検査 kn-keyword=新生児聴覚スクリーニング検査 en-keyword=小児難聴 kn-keyword=小児難聴 en-keyword=補聴器・人工内耳 kn-keyword=補聴器・人工内耳 en-keyword=言語発達 kn-keyword=言語発達 en-keyword=遺伝子診断 kn-keyword=遺伝子診断 END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=1 article-no= start-page=89 end-page=97 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Inhibitory Effects of Prior Low-dose X-irradiation on Cold-induced Brain Injury in Mouse en-subtitle= kn-subtitle= en-abstract= kn-abstract=We examined the inhibitory effects of low-dose X-irradiation on mouse brain tissue with cold-induced injury by comparing tissue samples from three groups of mice: control, sham-irradiated cold-exposed, and X-ray-irradiated (0.5 Gy) cold-exposed mice. The water content in brain increased significantly in the sham-irradiated group following the cold-induced injury relative to the control group. However, water content in brain tissue from the X-ray-irradiated group was significantly lower than that from the sham-irradiated group. Levels of antioxidants, such as superoxide dismutase and glutathione, in brain tissue from the X-ray-irradiated group were higher than those from the sham-irradiated group. Moreover, the cold injury-induced cell death, particularly apoptosis, while low-dose irradiation inhibited cell death, especially among glial cells, but not numeral cells. These findings suggest that prior low-dose X-irradiation activated antioxidant function and inhibited cold-induced brain injury. en-copyright= kn-copyright= en-aut-name=YoshimotoMasaaki en-aut-sei=Yoshimoto en-aut-mei=Masaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ToyotaTeruaki en-aut-sei=Toyota en-aut-mei=Teruaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TaguchiTakehito en-aut-sei=Taguchi en-aut-mei=Takehito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University en-keyword=cold injury kn-keyword=cold injury en-keyword=brain edema kn-keyword=brain edema en-keyword=0.5 Gy irradiation kn-keyword=0.5 Gy irradiation en-keyword=antioxidative function kn-keyword=antioxidative function END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=トリフルオロ乳酸エステルを用いた結晶工学及びその物性に関する研究 kn-title=Study on Crystal Engineering and Application Based on Trifluorolactates en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaKeisuke en-aut-sei=Kataoka en-aut-mei=Keisuke kn-aut-name=片岡啓介 kn-aut-sei=片岡 kn-aut-mei=啓介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=転移性脊椎腫瘍における予後予測因子の統計学的解析 kn-title=Statistical Analysis of Prognostic Factors for Survival in Patients with Spinal Metastasis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaMasaki en-aut-sei=Kataoka en-aut-mei=Masaki kn-aut-name=片岡昌樹 kn-aut-sei=片岡 kn-aut-mei=昌樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=1 article-no= start-page=41 end-page=45 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Current state and challenges of Japanese medical education kn-title=医療人育成の現況と課題 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaHitomi U en-aut-sei=Kataoka en-aut-mei=Hitomi U kn-aut-name=片岡仁美 kn-aut-sei=片岡 kn-aut-mei=仁美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　地域医療人材育成 en-keyword=医学教育 kn-keyword=医学教育 en-keyword=地域医療教育 kn-keyword=地域医療教育 en-keyword=女性医師支援 kn-keyword=女性医師支援 en-keyword=プロフェッショナリズム kn-keyword=プロフェッショナリズム en-keyword=empathy kn-keyword=empathy END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=1 article-no= start-page=59 end-page=62 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Gastric aberrant pancreas with acute pancreatitis treated with surgery kn-title=膵炎を伴った胃異所性膵の1切除例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We experienced a case of gastric aberrant pancreas with acute pancreatitis. The patient was a 42-year-old man. He was referred to our hospital because of epigastric pain. A CT scan and endoscopic examination revealed a gastric submucosal tumor with inflammation. His serum amylase level was high at 222 IU/l. Endoscopic ultrasonography revealed a hypoechoic mass lesion, 3 cm in diameter, at the body of his stomach. Endoscopic ultrasoundscopy-guided fine needle aspiration was performed. Pathological examination showed pancreatic tissue. So, he underwent partial gastrectomy due to gastric aberrant pancreas with pancreatitis. There are very few cases of gastric aberrant pancreas with pancreatitis on record. en-copyright= kn-copyright= en-aut-name=ShinouraSusumu en-aut-sei=Shinoura en-aut-mei=Susumu kn-aut-name=篠浦先 kn-aut-sei=篠浦 kn-aut-mei=先 aut-affil-num=1 ORCID= en-aut-name=YagiTakahito en-aut-sei=Yagi en-aut-mei=Takahito kn-aut-name=八木孝仁 kn-aut-sei=八木 kn-aut-mei=孝仁 aut-affil-num=2 ORCID= en-aut-name=SadamoriHiroshi en-aut-sei=Sadamori en-aut-mei=Hiroshi kn-aut-name=貞森裕 kn-aut-sei=貞森 kn-aut-mei=裕 aut-affil-num=3 ORCID= en-aut-name=MatsudaHiroaki en-aut-sei=Matsuda en-aut-mei=Hiroaki kn-aut-name=松田浩明 kn-aut-sei=松田 kn-aut-mei=浩明 aut-affil-num=4 ORCID= en-aut-name=UmedaYuzo en-aut-sei=Umeda en-aut-mei=Yuzo kn-aut-name=楳田祐三 kn-aut-sei=楳田 kn-aut-mei=祐三 aut-affil-num=5 ORCID= en-aut-name=YoshidaRyuichi en-aut-sei=Yoshida en-aut-mei=Ryuichi kn-aut-name=吉田龍一 kn-aut-sei=吉田 kn-aut-mei=龍一 aut-affil-num=6 ORCID= en-aut-name=SatohDaisuke en-aut-sei=Satoh en-aut-mei=Daisuke kn-aut-name=佐藤太佑 kn-aut-sei=佐藤 kn-aut-mei=太佑 aut-affil-num=7 ORCID= en-aut-name=UtsumiMasashi en-aut-sei=Utsumi en-aut-mei=Masashi kn-aut-name=内海方嗣 kn-aut-sei=内海 kn-aut-mei=方嗣 aut-affil-num=8 ORCID= en-aut-name=YokomichiNaosuke en-aut-sei=Yokomichi en-aut-mei=Naosuke kn-aut-name=横道直佑 kn-aut-sei=横道 kn-aut-mei=直佑 aut-affil-num=9 ORCID= en-aut-name=KuiseTakashi en-aut-sei=Kuise en-aut-mei=Takashi kn-aut-name=杭瀬崇 kn-aut-sei=杭瀬 kn-aut-mei=崇 aut-affil-num=10 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 en-keyword=異所性膵 (ectopic pancreas) kn-keyword=異所性膵 (ectopic pancreas) en-keyword=迷入膵 (aberrant pancreas) kn-keyword=迷入膵 (aberrant pancreas) en-keyword=粘膜下腫瘍 (submucosal tumor) kn-keyword=粘膜下腫瘍 (submucosal tumor) en-keyword=急性膵炎 (acute pancreatitis) kn-keyword=急性膵炎 (acute pancreatitis) en-keyword=胃 (stomach) kn-keyword=胃 (stomach) END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非寛解期白血病に対する血縁ドナーからの同種造血幹細胞移植における移植片対宿主病の臨床的影響。日本造血細胞移植学会作業部会報告 kn-title=Clinical impact of graft-versus-host disease against leukemias not in remission at the time of allogeneic hematopoietic stem cell transplantation from related donors. The Japan Society for Hematopoietic Cell Transplantation Working Party en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaItaru en-aut-sei=Kataoka en-aut-mei=Itaru kn-aut-name=片岡到 kn-aut-sei=片岡 kn-aut-mei=到 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=2 article-no= start-page=129 end-page=132 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Laparoscopic surgery for mesenteric Castleman's disease kn-title=腹腔鏡下に摘出しえた上行結腸間膜発生のCastleman病の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report herein a case of mesenteric Castleman's disease which was confirmed on pathology. A 60-year-old man was admitted to our hospital complaining of abdominal pain. On the physical examination, there was no palpable mass. Computed tomography findings and magnetic resonance imaging revealed a well circumscribed, lobulated round mass on the right side of the superior mesenteric vein. Laparoscopic surgery for the mesenteric tumor was carried out to obtain a definite diagnosis and treatment. In the operative field, the mass was located on the ascending colic mesentery and measured about 3 cm in size. It was solid and surrounded by a thin fibrous capsule. The histological diagnosis of the mesenteric tumor was hyaline vascular type Castleman's disease. The postoperative course of the patient was uneventful, and he was discharged on the 10th postoperative day. en-copyright= kn-copyright= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=1 ORCID= en-aut-name=OtsukaShinya en-aut-sei=Otsuka en-aut-mei=Shinya kn-aut-name=大塚真哉 kn-aut-sei=大塚 kn-aut-mei=真哉 aut-affil-num=2 ORCID= en-aut-name=TomodaJun en-aut-sei=Tomoda en-aut-mei=Jun kn-aut-name=友田純 kn-aut-sei=友田 kn-aut-mei=純 aut-affil-num=3 ORCID= en-aut-name=FujiwaraKeishi en-aut-sei=Fujiwara en-aut-mei=Keishi kn-aut-name=藤原敬士 kn-aut-sei=藤原 kn-aut-mei=敬士 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　内科 affil-num=4 en-affil= kn-affil=光生病院　内科 en-keyword=結腸間膜 (mesocolon) kn-keyword=結腸間膜 (mesocolon) en-keyword=Castleman病 (Castleman's disease) kn-keyword=Castleman病 (Castleman's disease) en-keyword=腹腔鏡手術 (laparoscopic surgery) kn-keyword=腹腔鏡手術 (laparoscopic surgery) END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=2 article-no= start-page=91 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=201104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=An Assessment of Radioactivity Levels of 210Pb and 40K in Tobacco and Radiation Exposure from Smoking en-subtitle= kn-subtitle= en-abstract= kn-abstract=No research has been conducted on the radiation influence of tobacco on the alimentary system, although there have been some previous works on the respiratory system. In this study, the radioactive concentrations of 210Pb and 40K in a cigarette sample were first measured. The transfer factors of the nuclides from tobacco into smoke and solution (saliva and/or alcohol) were then examined. Moreover, the radiation doses from smoke inhalation were also evaluated. The radioactive concentrations of 210Pb and 40K in the cigarette tobacco were 0.01 and 0.3 Bq/cigarette. Since this 210Pb activity and the 210Po activity previously reported for the same sample were comparable, it can be concluded that there was a radioactive equilibrium between the 2 nuclides. The observed transfer factor of 210Pb (12%) into smoke was almost the same as that of 40K (15%), whereas the reported value for 210Po (60%) was significantly higher. The radiation doses due to inhalation of cigarette smoke varied from organ to organ, depending on the organotropic properties of the nuclide. For example, the kidneys, respiratory tract, and spleen showed relatively high doses from 210Pb and 210Po. The leaching rates indicated an inconsistent tendency related to solution types. This result could suggest that alcohol drinking, which is common in smokers, does not especially enhance the leaching characteristics. en-copyright= kn-copyright= en-aut-name=NagamatsuTomohiro en-aut-sei=Nagamatsu en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OnoToshiro en-aut-sei=Ono en-aut-mei=Toshiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=4 en-affil= kn-affil=Department of Radiation Research Shikata Laboratory, Advanced Science Research Center, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University en-keyword=tobacco kn-keyword=tobacco en-keyword=radionuclides kn-keyword=radionuclides en-keyword=smoking kn-keyword=smoking en-keyword=intake kn-keyword=intake en-keyword=radiation exposure kn-keyword=radiation exposure END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=2 article-no= start-page=81 end-page=89 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=201104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Macrophage Is a Key Factor in Renal Injuries Caused by Glomerular Hyperfiltration en-subtitle= kn-subtitle= en-abstract= kn-abstract=Glomerular hyperfiltration is a common pathway leading to glomerulosclerosis in various kinds of kidney diseases. The 5/6 renal ablation is an established experimental animal model for glomerular hyperfiltration. On the other hand, low-grade inflammation is also a common mechanism for the progression of kidney diseases including diabetic nephropathy and atherosclerosis. Here we analyzed the gene expression profile in the remnant kidney tissues of 5/6 nephrectomized mice using a DNA microarray system and compared it with that of sham-operated control mice. The 5/6 nephrectomized mice showed glomerular hypertrophy and an increase in the extracellular matrix in the glomeruli. DNA microarray analysis indicated the up-regulated expression of various kinds of genes related to the inflammatory process in remnant kidneys. We confirmed the up-regulated expression of platelet factor-4, and monocyte chemoattractant protein-1, 2, and 5 in remnant kidneys by RT-PCR. The current results suggest that the inflammatory process is involved in the progression of glomerulosclerosis and is a common pathway of the pathogenesis of kidney disease. en-copyright= kn-copyright= en-aut-name=SasakiMotofumi en-aut-sei=Sasaki en-aut-mei=Motofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShikataKenichi en-aut-sei=Shikata en-aut-mei=Kenichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkadaShinichi en-aut-sei=Okada en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiyamotoSatoshi en-aut-sei=Miyamoto en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NishishitaShingo en-aut-sei=Nishishita en-aut-mei=Shingo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=Usui KataokaHitomi en-aut-sei=Usui Kataoka en-aut-mei=Hitomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SatoChikage en-aut-sei=Sato en-aut-mei=Chikage kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OgawaDaisuke en-aut-sei=Ogawa en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=kidney kn-keyword=kidney en-keyword=inflammation kn-keyword=inflammation en-keyword=chemokine kn-keyword=chemokine END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=11 article-no= start-page=2598 end-page=2612 dt-received= dt-revised= dt-accepted= dt-pub-year=1940 dt-pub=19401130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Einfluss des Fleischextraktes auf den Kohlehydratstoffwechsel kn-title=肉「エキス」ノ糖代謝ニ及ボス影響 其ノ1 血糖ニ及ボス影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verfasser hat den Einfluss des Extraktes von Rindfleisch auf den Kohlehydratstoffwechsel im Kaninchenorganismus studiert und folgendes gefunden: 1. Der rohe, schwach saure Extrakt hat bei peroraler Zufuhr eine starke hyperglykamische Wirkung, die entweder durch Abstumpfung der Reaktion oder durch Alkalisierung der Reaktion etwas abgeschwacht, aber durch Entfettung des Extraktes im Gegenteil etwas verstarkt gefunden wurde. 2. Diese hyperglykämische Wirkung des Fleischextraktes trat 1/2-1 Stunde nach seiner Verabreichung auf und dauerte 4-5 Stunden lang an, um dann zum normalen Wert zurückzukehren. 3. Durch Fütterung von entfettetem und enteiweisstem Extrakt wurde der Blutzuckergehalt herabgesetzt. Diese hypoglykämische Wirkung trat 4 Stunden nach der Zufuhr von Extrakt am stärksten auf. 4. Die hypoglykämische Wirkung der Cholsäure ist mit der des entfetteten und enteiweissten Extraktes synergisch. 5. Der entfettete und enteiweisste Extrakt zeigte auch bei Entfernung der Purinbasen eine hypoglykämische Wirkung, was höchstwahrscheinlich auf der Wirkung einer Kreatin im Extrakt beruhen durfte. 6. Die hyperglykämische Wirkung des rohen Fleischextraktes konnte durch Mitzufuhr von Phosphatpuffer fast oder ganz aufgehoben werden. en-copyright= kn-copyright= en-aut-name=KataokaYoshimi en-aut-sei=Kataoka en-aut-mei=Yoshimi kn-aut-name=片岡穆 kn-aut-sei=片岡 kn-aut-mei=穆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學生化學教室 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=10 article-no= start-page=2131 end-page=2137 dt-received= dt-revised= dt-accepted= dt-pub-year=1941 dt-pub=19411031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Einfluss deg Fleischextraktes auf den Kohlehydratstoffwechsel II. kn-title=肉「エキス」ノ糖代謝ニ及ボス影響 其ノ2 肝糖原質ニ及ボス影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verfasser hat den Einfluss des Fleischextraktes, über dessen hyperglykämische Wirkung in der vorausgegangenen Mitteilung berichtet wurde, aufdie Glykogenassimilation der Rattenleber untersucht. Es ergab sich folgendes: 1) Das Leberglykogen der Ratte wurde durch perorale Zufuhr von schwach sauer reagierendem, rohem Fleischextrakt ziemlich stark vermindert. 2) Die Wirkung des Fleischextraktes wurde durch Neutralisation sowie dusch Alkalimachen mit Natriumbicarbonat etwas abgescnwächt und durch Mitzufuhr von Phosphatpuffer (PH=8) fast aufgehoben. 3) Während die glykogenmobilisierende Wirkung des Fleischextraktes durch seine Entfettung etwas verstärkt wurde, trat dagegen eine glykogenbildende Wirkung der Rattenleber durch Zufuhr von enteiweisstem Fleischextrakt zu Tage. Diese Wirkung dürfte hauptsächlich auf seiner Purinfraktion beruhen, was aus der Tatsache hervorgeht, dass die genannte Wirkung durch Entfernung derselben Fraktion mittelst AgNo3-Methode (Kossel-Kutscher) fast vollständig verschwindet. 4) Die glykogenbildende Wirkung des enteiweissten Extraktes erwies sich als synergisch mit der der Cholsäure. en-copyright= kn-copyright= en-aut-name=KataokaYosimi en-aut-sei=Kataoka en-aut-mei=Yosimi kn-aut-name=片岡穆 kn-aut-sei=片岡 kn-aut-mei=穆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學生化學教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-2 article-no= start-page=6827 end-page=6841 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Various Vitamins loaded to Bone-Marrow Tissue Culture Part 3. Effects of Various Vitamins on the Erythrocyte Series kn-title=骨髄組織培養に対する各種ビタミン添加の影響 第3編 各種ビタミンの赤血球系造血に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author studied the effects of various vitamins on the cells of the erythrocyte series by performing the bone-marrow tissue culture of normal rabbits, and obtained the following results. 1. It has been found that vitamin B(1), cocarboxylase, vitamins B(2) and C, nicotinic acid, and vitamin K possess no power directly increasing the number of the erythrocyte series in the bone marrow. 2. Vitamin B(2) seems to be activated in vivo and transformed to FMN (flavin mononucleotide) or FAD while nicotinic acid in the form of DPN (diphosphophopyridine nucleotide) or TPN (triphosphopyrine nucleotide) can only play a role in the hematopoiesis, and it is believed that these vitamins at least in their original forms can not act directly on the bone marrow as to accelerate erythropoiesis. 3. Folic acid is first activated in vivo and trasformed to citovorum factor, and it is this latter factor that acts on the bone marrow as to accelerate the maturation of erythrocytes, but it does not have any effect on the erythropoiesis of the bone marrow in its original form. 4. FAD and vitamin B(6) have been found to have the power to accelerate erythropoiesis of the bone marrow though only slightly. 5. It has been recognized that vitamin B(12) acts directly on the bone marrow and markedly accelerates erythropoiesis of the bone marrow. 6. All these vitamins tested have no accelerating offect on the hemoglobin synthesis. en-copyright= kn-copyright= en-aut-name=KataokaRyosi en-aut-sei=Kataoka en-aut-mei=Ryosi kn-aut-name=片岡良司 kn-aut-sei=片岡 kn-aut-mei=良司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-2 article-no= start-page=6815 end-page=6825 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Various Vitamins loaded to Bone-Marrow Tissue Culture Part 2. Effects of Various Vitamins on Carbon-particle Phagocytosis and Vital Staining of Pseudoeosinophils kn-title=骨髄組織培養に対する各種ビタミン添加の影響 第2編 各種ビタミンの偽好酸球墨粒貪喰能及び生体染色性に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By performing a series of bone-marrow tissue culture of normal rabbits the author studied the effects of various vitamins on carbon-particle phagocytosis and neutral red vital staining of pseudoeosinophils, and obtained the following results. 1. Cocarboxylase, vitamins B(2) and K have no accelerating effect on carbon-particle phagocytosis of pseudoeosinophils nor any effect on the vital staining, suggesting that these substances have no effect directly accelerating the functions of pseudoeosinophils. 2. Vitamins B(1), B(6) and nicotinic acid in a certain adequate concentration only accelerate the carbon-particale phagocytosis of pseudoeosinophils slightly but no neutral red vital staining effect. 3. With vitamin B(12) and folic acid a marked acceleration of the carbon-particle phagocy tosis and a slight acceleration with FAD and vitamin C can be recognized. Likewise from the standpoint of the neutral red vital staining these seem to possess the accelerating action on the functions of pseudoeosinophils. en-copyright= kn-copyright= en-aut-name=KataokaRyosi en-aut-sei=Kataoka en-aut-mei=Ryosi kn-aut-name=片岡良司 kn-aut-sei=片岡 kn-aut-mei=良司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-2 article-no= start-page=6797 end-page=6813 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Various Vitamins loaded to Bone-Marrow Tissue Culture Part 1. Effects of Various Vitamins on the Tissue Growth and Motility of Pseudoeosinophils kn-title=骨髄組織培養に対する各種ビタミン添加の影響 第1編 各種ビタミンの組織増生並に偽好酸球の運動能に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By loading various vitamins to the bone-marrow tissue culture of normal rabbits the author observed systematically the influences of these vitamins on the cell growth and on the cell function of the leucocyte series, especially on the motility of pseudoeosinophils, and obtained the following results. 1. In vitamin B(1), cocarboxylase, vitamin B(2), and vitamin K there can be found no direct action as to increase the number of cells in the bone marrow leucocyte series. 2. Vitamin B(12) and folic acid have been found to possess a power markedly to increase the number of the leucocyte series in bone marrow. 3. Vitamin C has a moderate power, while FAD (flavin adenine dinucleotide), vitamin B(6), nicotinic acid, and nicotinamide in an adequate concentration only have the power directly increasing the number of the leucocyte series. 4. Vitamins B(1), B(6), and C as well as folic acid have been found to act as to accelerate the wandering velocity of pseudoeosinophils. en-copyright= kn-copyright= en-aut-name=KataokaRyosi en-aut-sei=Kataoka en-aut-mei=Ryosi kn-aut-name=片岡良司 kn-aut-sei=片岡 kn-aut-mei=良司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=8 article-no= start-page=1343 end-page=1349 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20068 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Using assessment of higher brain functions of children with GJB2-associated deafness and cochlear implants as a procedure to evaluate language development en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Objective: While investigators have reported that patients with GJB2-associated deafness and cochlear implants have preferable language development, the mechanisms of this phenomenon remains unknown. The goat of the present study was to assess higher brain functions of patients with GJB2-retated and GJB2-unrelated deafness as a method of evaluating language development.
Methods: Eight children with cochlear implants were subjected to genetic testing for GJB2 and underwent the Raven colored progressive matrices test, Rey's auditory verbal learning test, Rey's complex figure test, the standardized Language test for aphasia, the picture vocabulary test, and the standardized comprehension test for abstract words.
Results:Three children were diagnosed with GJB2-related deafness, and five children were diagnosed with GJB2-unrelated deafness. All three GJB2-related cases demonstrated normal range higher brain functions and fair language development. By contrast, one GJB2-unrelated case showed a semantic disorder, another demonstrated a visual cognitive disorder with dyslexia, and another had attention deficit-hyperactivity disorder.
Conclusions:Children with GJB2-unrelated deafness showed a high frequency of heterogeneous disorders that can affect proper language development. This difference between children with GJB2-retated and GJB2-unrelated deafness may account for the improved language development in children with GJB2-related deafness and cochlear implants. Further, genetic diagnosis of the non-syndromic hearing toss represents a useful tool for the preoperative prediction of outcomes following a cochlear implant procedure.

en-copyright= kn-copyright= en-aut-name=KawasakiAkihiro en-aut-sei=Kawasaki en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FukushimaKunihiro en-aut-sei=Fukushima en-aut-mei=Kunihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KataokaYuko en-aut-sei=Kataoka en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FukudaShoichiro en-aut-sei=Fukuda en-aut-mei=Shoichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NishizakiKazunori en-aut-sei=Nishizaki en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University en-keyword=cochlear implant kn-keyword=cochlear implant en-keyword=higher brain function kn-keyword=higher brain function en-keyword=GJB2 kn-keyword=GJB2 en-keyword=language development kn-keyword=language development en-keyword=non-syndromic hearing loss kn-keyword=non-syndromic hearing loss en-keyword=learninng disability kn-keyword=learninng disability END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=2 article-no= start-page=75 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=201004 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Experimental Pulmonary Granuloma Mimicking Sarcoidosis Induced by Propionibacterium acnes in Mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Propionibacterium acnes has been implicated as an etiologic agent of sarcoidosis since the isolation of this bacterium from sarcoid lesions. We experimentally produced a murine pulmonary granuloma model using P. acnes with several features that simulate sarcoidosis. Mice were sensitized with heat-killed P. acnes and complete Freund's adjuvant and were subsequently challenged with heat-killed P. acnes at 2-week intervals. P. acnes-challenged mice developed epitheloid cell granulomas in the lungs. These mice showed a pulmonary immune response characterized by an increased number of T-lymphocytes, especially CD4 cells, and the ratio of CD4/CD8 in bronchoalveolar lavage (BAL) fluid also increased. Furthermore, significant elevations in both angiotensin-converting enzyme (ACE) serum levels and antibody titers against P. acnes were observed. Mice sensitized with P. acnes without complete Freund's adjuvant were capable of forming pulmonary granulomas, which appeared to be caused by indigenous P. acnes. The genome of P. acnes was found in the lungs, BAL cells, hilar lymph nodes, liver, and spleen in non-sensitized mice, which were thought to be germ-free. These results suggest that the immune response against indigenous P. acnes may play an important role in the pathogenesis of granuloma formation in a murine model.

en-copyright= kn-copyright= en-aut-name=IioKouji en-aut-sei=Iio en-aut-mei=Kouji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IioTomoe Ueno en-aut-sei=Iio en-aut-mei=Tomoe Ueno kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkuiYuhei en-aut-sei=Okui en-aut-mei=Yuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IchikawaHirohisa en-aut-sei=Ichikawa en-aut-mei=Hirohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanimotoYasushi en-aut-sei=Tanimoto en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyaharaNobuaki en-aut-sei=Miyahara en-aut-mei=Nobuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KanehiroArihiko en-aut-sei=Kanehiro en-aut-mei=Arihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NakataYasunari en-aut-sei=Nakata en-aut-mei=Yasunari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Field of Medical Technology, Graduate School of Health Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Field of Medical Technology, Graduate School of Health Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Field of Medical Technology, Graduate School of Health Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Field of Medical Technology, Graduate School of Health Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Field of Medical Technology, Graduate School of Health Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=Propionibacterium acnes kn-keyword=Propionibacterium acnes en-keyword=experimental granuloma kn-keyword=experimental granuloma en-keyword=sarcoidosis kn-keyword=sarcoidosis END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue=1 article-no= start-page=31 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clinical features of 125 patients with sarcoidosis: Okayama University Hospital review of a recent 10-year period. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Clinical features were studied in 125 patients with sarcoidosis (72 females and 53 males) diagnosed at Okayama University Hospital during a recent 10-year period. The age distribution had two peaks in patients in their 20s and the 50s. Over half of the patients were detected at health screening check and were asymptomatic, while the remaining were symptomatic. Twelve patients were in stage 0, 41 were in stage I, 54 were in stage II, 16 were in stage III, and 2 were in stage IV according to the chest x-ray findings. Serum angiotensin converting enzyme levels and serum lysozyme levels were elevated in 60% and 76% of the patients, respectively. The bronchoalveolar lavage fluid showed lymphocytosis, especially of helper T-cells. The clinical features of sarcoidosis appear to depend on the duration of the disease.

en-copyright= kn-copyright= en-aut-name=HosoyaShigee en-aut-sei=Hosoya en-aut-mei=Shigee kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakataYasunari en-aut-sei=Nakata en-aut-mei=Yasunari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MaedaTsuyoshi en-aut-sei=Maeda en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NishizakiHiroshi en-aut-sei=Nishizaki en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HiokaTohru en-aut-sei=Hioka en-aut-mei=Tohru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MoriYoshihiro en-aut-sei=Mori en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=EjiriTougo en-aut-sei=Ejiri en-aut-mei=Tougo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ShiomiKatsuhiko en-aut-sei=Shiomi en-aut-mei=Katsuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=UeokaHiroshi en-aut-sei=Ueoka en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=NumataTakeyuki en-aut-sei=Numata en-aut-mei=Takeyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NishiiKenji en-aut-sei=Nishii en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KodaniTsuyoshi en-aut-sei=Kodani en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=MoritaniYoshiaki en-aut-sei=Moritani en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=OhnoshiTaisuke en-aut-sei=Ohnoshi en-aut-mei=Taisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University affil-num=9 en-affil= kn-affil=Okayama University affil-num=10 en-affil= kn-affil=Okayama University affil-num=11 en-affil= kn-affil=Okayama University affil-num=12 en-affil= kn-affil=Okayama University affil-num=13 en-affil= kn-affil=Okayama University affil-num=14 en-affil= kn-affil=Okayama University affil-num=15 en-affil= kn-affil=Okayama University affil-num=16 en-affil= kn-affil=Okayama University en-keyword=sarcoidosis kn-keyword=sarcoidosis en-keyword=serum angiotesin converting enzyme kn-keyword=serum angiotesin converting enzyme en-keyword=bronchoalveolar lavage kn-keyword=bronchoalveolar lavage END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=6 article-no= start-page=471 end-page=478 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=197912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Immuno-chemotherapy of malignant lymphoma using OK-432, a streptococcal agent en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Clinical trials of immuno-chemotherapy were conducted on malignant lymphoma patients. Patients during the period from 1972 through 1977 were allocated to two groups retrospectively according to the mode of treatment, i.e., chemotherapy alone (historical control group, 35 patients) and chemotherapy with OK-432 (treated group, 15 patients). Comparisons were made of the two groups, which were homogeneous with regard to induction chemotherapy, maintenance chemotherapy, stage and histologic type of disease. The treated group had a higher remission rate, and a longer remission duration and survival than the control groups, especially in patients with Hodgkin's disease but the difference was not statistically significant owing to the limited number of cases.

en-copyright= kn-copyright= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhnoshiTaisuke en-aut-sei=Ohnoshi en-aut-mei=Taisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakataYasunari en-aut-sei=Nakata en-aut-mei=Yasunari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakasugiKenta en-aut-sei=Takasugi en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujiiMasafumi en-aut-sei=Fujii en-aut-mei=Masafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HayashiKyoichi en-aut-sei=Hayashi en-aut-mei=Kyoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SatoMasaharu en-aut-sei=Sato en-aut-mei=Masaharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NishiharaRyuji en-aut-sei=Nishihara en-aut-mei=Ryuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University affil-num=9 en-affil= kn-affil=Okayama University en-keyword=malignant lymphoma kn-keyword=malignant lymphoma en-keyword=chemotherapy kn-keyword=chemotherapy en-keyword=nonspecific immunotherapy kn-keyword=nonspecific immunotherapy en-keyword=OK-432 kn-keyword=OK-432 END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=2 article-no= start-page=83 end-page=89 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=200104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The role of fibronectin in bronchoalveolar lavage fluid of asthmatic patients. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Allergic and chronic inflammation of the airway is regarded as the main pathogenesis of bronchial asthma, in which adhesion of inflammatory cells requires the expression of adhesion molecules. Thus, to clarify the role of fibronectin (FN) in the airway inflammation of bronchial asthma, FN levels in plasma and bronchoalveolar lavage fluid (BALF) from bronchial asthmatics were determined. FN concentrations in plasma and BALF were measured by enzyme-linked immunosorvent assay (ELISA) in 17 asthmatic patients and 10 healthy controls to elucidate the role of FN in allergic inflammation. The mean FN/albumin (Alb) level in the BALF of asthmatic patients was 2.973 micrograms/mg, which was significantly higher than that of healthy controls (0.727 microgram/mg). Non-atopic asthmatics showed a significantly higher level of FN in their BALF in comparison with atopic asthmatics, although the ratio of FN to albumin showed no significant difference. FN levels in BALF correlated significantly with total cell density (r = 0.71, P < 0.05) and alveolar macrophage density (r = 0.64, P < 0.05). FN levels in plasma did not correlate with those in BALF. In conclusion, increased FN in BALF, which was produced locally in the airways of asthmatic patients, is actively involved in the regulation of allergic inflammation.

en-copyright= kn-copyright= en-aut-name=OhkeMasashi en-aut-sei=Ohke en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NabeMakoto en-aut-sei=Nabe en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MatsuoKiyoshi en-aut-sei=Matsuo en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University en-keyword=airway inflammation kn-keyword=airway inflammation en-keyword=adhesion molecule kn-keyword=adhesion molecule en-keyword=bronchoalveolar lavage fluid kn-keyword=bronchoalveolar lavage fluid en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=fibronectin kn-keyword=fibronectin END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=4 article-no= start-page=205 end-page=211 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=200108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Intercellular adhesion molecule-1 in patients with idiopathic interstitial pneumonia. en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakeharaHideki en-aut-sei=Takehara en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MatsuoKiyoshi en-aut-sei=Matsuo en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=UenoYoshiki en-aut-sei=Ueno en-aut-mei=Yoshiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OzakiShinji en-aut-sei=Ozaki en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MiyakeToshitsugu en-aut-sei=Miyake en-aut-mei=Toshitsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=FujimoriYoshiaki en-aut-sei=Fujimori en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamadoriIchiro en-aut-sei=Yamadori en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Kagawa Labor Hospital affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University affil-num=9 en-affil= kn-affil=National Okayama Hospital affil-num=10 en-affil= kn-affil=Okayama University END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue=5 article-no= start-page=257 end-page=264 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Alveolar lymphocyte proliferation induced by Propionibacterium acnes in sarcoidosis patients. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The proliferation of lymphocytes induced by Propionibacterium acnes (P. acnes) was measured by the in vitro incorporation of 3H-thymidine. The mean response rate of alveolar lymphocytes obtained by bronchoalveolar lavage was 2.23 +/- 0.89 in nine untreated sarcoidosis patients, 0.85 +/- 0.17 in five sarcoidosis patients given corticosteroids and 0.78 +/- 0.29 in 11 controls. The proliferation was significantly enhanced in the untreated patients compared to both the treated patients (p less than 0.01) and controls (p less than 0.001), but there was no significant difference in response rates between the treated patients and controls. The response rate of alveolar lymphocytes was significantly higher in four active patients (3.05 +/- 0.61) than in four inactive patients (1.77 +/- 0.44) (p less than 0.05) and in the controls (p less than 0.001). In sarcoidosis patients, the response rates showed a good correlation with activities of serum lysozyme (r = 0.695, p less than 0.01), and with percentages of lymphocytes in bronchoalveolar lavage fluid (r = 0.591, p less than 0.05). There was a low correlation between angiotensin-converting enzyme activities and the response rates (r = 0.508, p less than 0.1). Neither peripheral blood lymphocytes in sarcoidosis patients nor in controls showed any response to P. acnes, but alveolar lymphocytes of the untreated active sarcoidosis patients were sensitive to P. acnes. The lymphocytes activated by P. acnes may play a central role in the induction of alveolitis in sarcoidosis patients.

en-copyright= kn-copyright= en-aut-name=NakataYasunari en-aut-sei=Nakata en-aut-mei=Yasunari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=EjiriTogo en-aut-sei=Ejiri en-aut-mei=Togo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KishiToshiyuki en-aut-sei=Kishi en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoriYoshihiro en-aut-sei=Mori en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HiokaTohru en-aut-sei=Hioka en-aut-mei=Tohru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OhnoshiTaisuke en-aut-sei=Ohnoshi en-aut-mei=Taisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University en-keyword=sarcoidosis kn-keyword=sarcoidosis en-keyword=alveolar lymphocyte kn-keyword=alveolar lymphocyte en-keyword=lymphocyte proliferation kn-keyword=lymphocyte proliferation en-keyword=Propionibacterium acnes kn-keyword=Propionibacterium acnes END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=6 article-no= start-page=393 end-page=401 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Mechanistic Analysis of Resistance to REIC/Dkk-3-induced Apoptosis in Human Bladder Cancer Cells en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We have recently shown that a new therapeutic modality using the REIC/Dkk-3 gene (Ad-REIC) is effective against various human cancers, including those of prostate, testis and breast origins. The aim of the present study was to examine the sensitivity of bladder cancers to Ad-REIC and to clarify the molecular mechanisms that determine sensitivity/resistance. We found that 2 human bladder cancer cell lines, T24 and J82, are resistant to Ad-REIC. In T24 and J82 cells, the ER stress response and activation of JNK were observed in a manner similar to that in the sensitive PC3 cells. Translocation of Bax to mitochondria occurred in PC3 cells but not in T24 and J82 cells. Bcl-2 was remarkably overexpressed in T24 and J82 compared with the expression levels in sensitive cell lines. Treatment of T24 and J82 cells with a Bcl-2 inhibitor sensitized the cells to Ad-REIC-induced apoptosis. The results indicate that some human bladder cancers are resistant to apoptosis induced by overexpression of REIC/Dkk-3, which is at least in part due to up-regulation of Bcl-2. These results provide a basis for possible use of Bcl-2 as a marker of sensitive cancers and to try to sensitize resistant cancers to Ad-REIC by down-regulation of Bcl-2.

en-copyright= kn-copyright= en-aut-name=KobayashiTomoko en-aut-sei=Kobayashi en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakaguchiMasakiyo en-aut-sei=Sakaguchi en-aut-mei=Masakiyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TanimotoRyuta en-aut-sei=Tanimoto en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AbarzuaFernando en-aut-sei=Abarzua en-aut-mei=Fernando kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakaishiMikiro en-aut-sei=Takaishi en-aut-mei=Mikiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KakuHaruki en-aut-sei=Kaku en-aut-mei=Haruki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KataokaKen en-aut-sei=Kataoka en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SaikaTakashi en-aut-sei=Saika en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NasuYasutomo en-aut-sei=Nasu en-aut-mei=Yasutomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MiyazakiMasahiro en-aut-sei=Miyazaki en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KumonHiromi en-aut-sei=Kumon en-aut-mei=Hiromi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=HuhNam-ho en-aut-sei=Huh en-aut-mei=Nam-ho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=11 en-affil= kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=12 en-affil= kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=REIC/Dkk-3 kn-keyword=REIC/Dkk-3 en-keyword=bladder cancer kn-keyword=bladder cancer en-keyword=apoptosis kn-keyword=apoptosis en-keyword=Bcl-2 kn-keyword=Bcl-2 END start-ver=1.4 cd-journal=joma no-vol=50 cd-vols= no-issue=1 article-no= start-page=37 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199602 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Factors affecting prognosis of idiopathic interstitial pneumonia. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

<P>Idiopathic interstitial pneumonia (IIP) is a progressive and often fatal pulmonary disorder, and evaluating the prognosis of patients with IIP has never been sufficient. Accordingly, factors including clinical features, laboratory data, cellular components in bronchoalveolar lavage (BAL) fluid and response to corticosteroid therapy were analyzed in 35 patients with IIP whose median age of respiratory onset was 60 years (range; 37-77 years). Nineteen patients (54.3%) were in the active stage of IIP and 16 of them were treated with corticosteroids. Significant prognostic factors were the neutrophil percentage in BAL fluid, interstitial shadows on chest radiograph, pulmonary function, blood oxygen level, grade of dyspnea, and disease activity at the initial examination. Patients in the active stage showed higher proportions of neutrophils and eosinophils in BAL fluid than those in the non-active stage. Despite corticosteroid therapy, the survival of patients in the active stage was significantly shorter than those in the non-active stage. Fifty percent of the patients treated with corticosteroids were regarded as responders at 1 month after the initiation of therapy; however, there was no significant difference between responders and non-responders in terms of survival time. In conclusion, disease activity and neutrophils in BAL fluid may be important predictors of the prognosis of IIP.</P>

en-copyright= kn-copyright= en-aut-name=MatsuoKiyoshi en-aut-sei=Matsuo en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShibayamaTakuo en-aut-sei=Shibayama en-aut-mei=Takuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UenoYoshiki en-aut-sei=Ueno en-aut-mei=Yoshiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyakeToshitugu en-aut-sei=Miyake en-aut-mei=Toshitugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakeharaHideki en-aut-sei=Takehara en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama Univeristy affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University affil-num=9 en-affil= kn-affil=Okayama University en-keyword=idiopathic interstitial pneumonia (LLP) kn-keyword=idiopathic interstitial pneumonia (LLP) en-keyword=prognostic factor kn-keyword=prognostic factor en-keyword=corticosteroid therapy kn-keyword=corticosteroid therapy en-keyword= bronchoalveolar lavage(BAL) kn-keyword= bronchoalveolar lavage(BAL) en-keyword=disease activity kn-keyword=disease activity END start-ver=1.4 cd-journal=joma no-vol=3 cd-vols= no-issue= article-no= start-page=24 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=1985 dt-pub=198504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=各種哺乳動物の乳成分組成の比較 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学農学部畜産物利用学教室 END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=1 article-no= start-page=67 end-page=71 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Japanese guideline for management of cervical spondylotis myelopathy kn-title=頚椎症性脊髄症の診療ガイドライン en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TanakaMasato en-aut-sei=Tanaka en-aut-mei=Masato kn-aut-name=田中雅人 kn-aut-sei=田中 kn-aut-mei=雅人 aut-affil-num=1 ORCID= en-aut-name=SugimotoYoshihisa en-aut-sei=Sugimoto en-aut-mei=Yoshihisa kn-aut-name=杉本佳久 kn-aut-sei=杉本 kn-aut-mei=佳久 aut-affil-num=2 ORCID= en-aut-name=MisawaHaruo en-aut-sei=Misawa en-aut-mei=Haruo kn-aut-name=三澤治夫 kn-aut-sei=三澤 kn-aut-mei=治夫 aut-affil-num=3 ORCID= en-aut-name=TakahataTomohiro en-aut-sei=Takahata en-aut-mei=Tomohiro kn-aut-name=高畑智宏 kn-aut-sei=高畑 kn-aut-mei=智宏 aut-affil-num=4 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name=尾﨑敏文 kn-aut-sei=尾﨑 kn-aut-mei=敏文 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=12 article-no= start-page=4493 end-page=4500 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19581231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on coagulating time and serum bactericidal action of arterial and venous blood. Part 3. Studies on the difference between the serum bactericidal action of the arterial and venous blood kn-title=動脈血並に静脈血の血液凝固時間及び血清殺菌作用に関する研究 第3編 動脈血並に静脈血の血清殺菌作用の差異に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) In the dog, as to the bactericidal action, the blood of the femoral, pulmonary and hepatic veins are stronger than those of the femoral artery, pulmonary artery and the portal vein respectively. Among them the serum bactericidal action of the blood of the hepatic vein is the strongest. 2) In the human, the serum bactericidal actions of the blood of the cubital vein and pulmonary vein is stronger than that of the brachial artery and pulmonary artery. 3) The amount of serum γ-globulin is greater in the blood of the cubital vein and pulmonary vein than in that of the brachial artery and pulmonary artery respectively, prsssnting a correlation with the difference of serum bactericidal actions, thus suggesting their important roles in the bactericidal action. 4) The blood sugar level is a little higher in the blood of the brachial artery, femoral artery and pulmonary artery than in that of the cubital vein, pulmonary vein and femoral vein respectively; however, the blood sugar content of the hepatic vein and portal vein does not give a constant value. Consequently the blood sugar level in various vessels does not seem to have any significant relation to the difference of the serum bactericidal effect. en-copyright= kn-copyright= en-aut-name=KataokaKazuo en-aut-sei=Kataoka en-aut-mei=Kazuo kn-aut-name=片岡和男 kn-aut-sei=片岡 kn-aut-mei=和男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=12 article-no= start-page=4479 end-page=4492 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19581231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on coagulating time and serum bactericidal action of arterial and venous blood. Part 2. Experimental studies on the significance of the difference of the coagulating time between the arterial and venous blood in dogs kn-title=動脈血並に静脈血の血液凝固時間及び血清殺菌作用に関する研究 第2編 動脈血並に静脈血の血液凝固時間の差異の意義に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) As far as the number of the blood platelets is concerned, neither significant difference is observed between the carotid arterv and jugular vein, nor between the pulmonary artery and pulmonary vein, while the platelet number of the blood of the femoral vein is smaller than that of the femoral artery. On the other hand, the blood of the hepatic vein and portal vein contained a greater number of platelets than that of any other blood vessel. 2) The serum prothrombin time of the blood of the carotid, femoral and pulmonary arteries is a little shorter than that of the corresponding veins respectively. Those of the hepatic and portal veins are shorter than those of other vessels. The various organs and tissues of the hepato-portal system are thought to play an important role in production of prothrombin. 3) The serum calcium contents of the blood of various vessels show no significant differences. 4) As for amount of thrombin in the serum, the blood of the femoral and pulmonary arteries contains greater amount than that of the femoral and pulmonary vein respectively, The thrombin content of the hepatic and portal veins is still greater. 5) As far as the amount of serum fibrinogen is concerned, the carotid arterial blood and the pulmonary arterial blood show a greater value than the corresponding venous blood respectively. The blood of the hepatic and portal vein presents still greater estimate. 6) The amount of plasma protein shows no significant difference between various arteries and veins, although those of hepatic and portalveins give a slightly greater values than those of the other vessels. 7) The blood sugar values of the femoral and pulmonary arterial blood are slightly greater than those of the femoral and pulmonary venous blood respectively. 8) The phenomenon of fibrinolysis occurrs strongly in the blood of the femoral vein, while it occurrs more weakly in the blood of hepatic and portal veins compared with other blood vessels. 9) The number of blood platelets and the amount of prothrombin, thrombin, fibrinogen, serum protein and fibrinolysin have some relation respectively to the fact that the coagulating time of the blood of the carotid, pulmonary and femorary arteries is shorter than that of the corresponding veins respectively and that of the blood of the hepatic and portal veins is much shorter. Particularly the amounts of prothrombin, thrombin and fibrinogen are seen to play an important role. en-copyright= kn-copyright= en-aut-name=KataokaKazuo en-aut-sei=Kataoka en-aut-mei=Kazuo kn-aut-name=片岡和男 kn-aut-sei=片岡 kn-aut-mei=和男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=12 article-no= start-page=4471 end-page=4477 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19581231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on coagulating time and serum bactericidal action of arterial and venous blood. Part 1. Experimental studies on the difference of coagulating time between the arterial and venous blood in dogs kn-title=動脈血並に静脈血の血液凝固時間及び血清殺菌作用に関する研究 第1編 動脈血並に静脈血の血液凝固時間の差異に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) The coagulating time of the blood of the carotid artery is shorter than that of the jugular vein. 2) The coagulating time of the blood of the femoral artery is shorter than that of the femoral vein. 3) The coagulating time of the blood of the pulmonary artery is shorter than that of the pulmonaly vein. 4) Schmidt's theory, which ascribes the difference of the coagulating time between the arterial and venous blood to the difference of the amount of O(2) and CO(2), is not thought to be perfect. 5) The coagulating time of the blood of the thoracic interior vena cava is much shorter than that of the femoral vein. 6) The coagulating time of the blood of the hepatic vein and the portal vein is shorter than that of any other artery or vein. The coagulating time of the hepatic venous blood is a little shorter than that of the portal venous blood. 7) Among the three main roots of the portal vein, the coagulating time of the lienal venous blood is the shortest, then the superior mesenteric venous blood and the longest is that of the interior mesenteric venous blood. 8) The coagulaing time of the blood of the portal vein is shorter than those of its roots, viz. the lienal, superior and inferior mesenteric veins. 9) The fact that the blood coagulating time of the thoracic inferior vena cava is much shorter than that of the femoral vein is accounted for the inflow of the blood from the hepatic vein. 10) The fact that the blood coagulating time of the pulmonary vein is longer than that of the thoracic inferior vena cava is ascribed to the blood inflow from the jugular vein. 11) The coagulating time of the blood is prolonged after its perfusion through various organs except those of the hepato-portal system. en-copyright= kn-copyright= en-aut-name=KataokaKazuo en-aut-sei=Kataoka en-aut-mei=Kazuo kn-aut-name=片岡和男 kn-aut-sei=片岡 kn-aut-mei=和男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=93 cd-vols= no-issue=5-6 article-no= start-page=499 end-page=506 dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=19810630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on human peripheral monocyte chemotaxis Part II. Monocyte chemotaxis in patients with bronchogenic carcinoma kn-title=ヒト末梢血単球の走性に関する研究 第2編 肺癌患者の単球走性 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The chemotactic responsiveness of peripheral blood monocytes was measured in 71 patients with bronchogenic carcinoma, 13 patients with sarcoidosis, 14 patients with pulmonary tuberculosis and 91 normal controls. The monocyte chemotactic response (MCR) was significantly depressed in patients with bronchogenic carcinoma (mean=19.6±6.6,P<0.001) as compared to normal controls (mean=33.7±7.4). On the other hand, MCR was significantly enhanced in patients with pulmonary tuberculosis (mean=41.6±7.9,P<0.01). There was no significant difference from normal controls in patients with sarcoidosis (mean=27.5±8.5). In bronchogenic carcinoma patients, depression of the MCR was observed in all clinical stages. The MCR was further depressed in patients with evidence of distant metastasis compared to those without metastasis. There was no significant correlation between the MCR and histologic types of tumors. The MCR was significantly lowered by combination chemotherapy in 21 cases who received chemotherapy, but was elevated in 5 of 6 patients who had a remission after combination chemotherapy. These data showed that monocyte function in patients with bronchogenic carcinoma was suppressed, and suggested that malignant tumors themselves might affect monocyte function. en-copyright= kn-copyright= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name=片岡幹男 kn-aut-sei=片岡 kn-aut-mei=幹男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科教室 en-keyword=monocyte kn-keyword=monocyte en-keyword=chemotaxis kn-keyword=chemotaxis en-keyword=bronchogenic carcinoma kn-keyword=bronchogenic carcinoma en-keyword=chemotherapy kn-keyword=chemotherapy END start-ver=1.4 cd-journal=joma no-vol=93 cd-vols= no-issue=5-6 article-no= start-page=489 end-page=498 dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=19810630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on human peripheral monocyte chemotaxis Part I. A technical study kn-title=ヒト末梢血単球の走性に関する研究 第1編 単球走性測定法の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The human monocyte is an important member of the host defence system, but has been little studied in vitro. In this report, I describe a reproducible and simple method for monocyte chemotaxis in man, using a Boyden chamber. Monocyte suspension was prepared by Ficoll-Hypaque gradient sedimentation. The purity of the suspension was checked with Peroxidase-Giemsa staining. Chemotaxis assay was performed using a 5 μm pore sized Millipore filter(thickness:150 μm) and a Nuclepore filter (thickness:13 μm). When the Millipore filter was used, migrated cells stayed in the filter, while it appeared that cells detached from the filter when the Nuclepore filter was used. In the modified Boyden method using a Millipore filter, more than 3×10(5) monocytes had to be added to the upper room of the chamber, and the duration of 90 minutes was adequate for incubation. Zymosan activated human serum diluted 20 percent was used as the chemoattractant. To estimate chemotaxis in the Millipore filter, migrated cells in the filter were counted at 30 μm depth. en-copyright= kn-copyright= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name=片岡幹男 kn-aut-sei=片岡 kn-aut-mei=幹男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科教室 en-keyword=monocyte kn-keyword=monocyte en-keyword=chemotaxis kn-keyword=chemotaxis en-keyword=Boyden chamber kn-keyword=Boyden chamber en-keyword=Millipore filter kn-keyword=Millipore filter END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=側貌骨格形態と下顎限界運動の関連性に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaTomoki en-aut-sei=Kataoka en-aut-mei=Tomoki kn-aut-name=片岡伴記 kn-aut-sei=片岡 kn-aut-mei=伴記 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=93 cd-vols= no-issue=3-4 article-no= start-page=361 end-page=381 dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=19810430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Quantitative Studies on Bleomycin-Induced Strand Breakage of Chromatin DNA kn-title=ブレオマイシンによるクロマチンDNA鎖切断の定量的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Single and double strand breakage of DNA by bleomycin under various conditions was analyzed quantitatively using purified simian virus 40 (SV40) DNA and SV40 chromatin. The method employed for DNA assay was fluorometry of SV40 DNA separated into three forms I, II, and III by 1.4% agarose gel electrophoresis and stained with ethidium bromide. This method was extremely simple and accurate for quantitative estimation of single and double strand breakage of circular DNA. The amount of bleomycin required for in vitro breakage of SV40 chromatin DNA was much higher than that of naked SV40 DNA. 2-Mercaptoethanol accerated bleomycin-induced DNA strand breakage. The concentration of 2-mercaptoethanol required for the acceleration was higher in SV40 chromatin than in SV40 DNA. DNA strand breakage was induced by ferrous ions in the absence of bleomycin to a similar level in SV40 chromatin and in SV40 DNA. The acceleration of bleomycin-induced strand breakage by a low concentration of ferrous ion was higher in SV40 DNA than in SV40 chromatin. Ethylenediaminetetraacetic acid (EDTA) and copper ions were not efficient for stopping the reaction of bleomycin-induced DNA breakage. Sodium dodecyl sulfate(SDS) was a useful reagent for stopping the reaction. en-copyright= kn-copyright= en-aut-name=KataokaKazuhiro en-aut-sei=Kataoka en-aut-mei=Kazuhiro kn-aut-name=片岡和博 kn-aut-sei=片岡 kn-aut-mei=和博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部癌源研究施設生化学部門 en-keyword=ブレオマイシン kn-keyword=ブレオマイシン en-keyword=SV40 kn-keyword=SV40 en-keyword=クロマチン kn-keyword=クロマチン en-keyword=DNA鎖切断 kn-keyword=DNA鎖切断 en-keyword=ゲル電気泳動 kn-keyword=ゲル電気泳動 END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=1 article-no= start-page=49 end-page=57 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cutaneous sarcoidosis : Clinical features and management kn-title=皮膚サルコイドーシスの臨床 ―最近20年間に岡山大学第2内科にて経験した65症例について― en-subtitle= kn-subtitle= en-abstract=Of 255 patients with clinical and histologic evidence of sarcoidosis, 65 (25percent) presented with various cutaneous manifestations of the disease. Cutaneous sarcoid patients were 42 women and 23 men ranging from 18 to 77 years in age. The skin lesions have included nodular infiltration in 33 patients, subcutaneous tumor in 16 patients, lupus pernio in 3, annual plaques in 6, erythema nodosum-like eruption in 3, lichinoid in 1, and scars in 9. There was no correlation between the presence of cutaneous lesions and chest radiolographic stages, abnormal pulmonary gallium uptake, cell differenciations of bronchoalveolar lavages and serum angiotensin converting enzyme activities. Forty-six patients followed for at least 3 years to determine the course of the disease. Subcutaneous tumors tended to heal within 3 years, while lupus pernio and plaque lesions were likely to have a protracted course. kn-abstract=1976年から1996年に岡山大学第2内科を受診したサルコイドーシス255例のうち,65例(71病変)の皮膚サルコイドーシス(皮膚サ症)について,臨床経過,臨床検査成績,胸部病変との関連,予後について検討した｡皮膚サ症患者の年齢は18歳から77歳で中央値は51歳であった｡女性例が42例(65%)と多 く,特に50歳代女性に43%と最も高率であった｡皮膚病型では結節型33例,皮下型16例,び慢浸潤型3例,局面型6例,結節性紅斑様皮疹3例,苔癬様型1例,瘢痕浸潤9例であった｡皮膚サ症では非皮膚サ症に比して気管支肺胞洗浄液中リンパ球の低率が見られたが,その他の臨床成績に差は認められなかった｡皮膚病型別に検討すると,局面型,び慢浸潤型では気管支肺胞洗浄液中リンパ球CD4/CD8比は高く,3年後の皮膚および肺病変の残存率は高かった｡一方皮下型ではCD4/CD8比は低く皮膚,肺病変の残存率も低かった｡ en-copyright= kn-copyright= en-aut-name=NakataYasunari en-aut-sei=Nakata en-aut-mei=Yasunari kn-aut-name=中田安成 kn-aut-sei=中田 kn-aut-mei=安成 aut-affil-num=1 ORCID= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name=片岡幹男 kn-aut-sei=片岡 kn-aut-mei=幹男 aut-affil-num=2 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=3 ORCID= en-aut-name=OkazakiKazunori en-aut-sei=Okazaki en-aut-mei=Kazunori kn-aut-name=岡崎和徳 kn-aut-sei=岡崎 kn-aut-mei=和徳 aut-affil-num=4 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 affil-num=2 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=3 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=4 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=5 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=サルコイドーシス (sarcoidosis) kn-keyword=サルコイドーシス (sarcoidosis) en-keyword=皮膚 (skin) kn-keyword=皮膚 (skin) en-keyword=臨床経過 (clinical-features) kn-keyword=臨床経過 (clinical-features) en-keyword=予後 (prognosis) kn-keyword=予後 (prognosis) END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue=1 article-no= start-page=37 end-page=45 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20031225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A study of patient's intake of meals provided by the hospital and its relevant factors using a self-administered questionnaire kn-title=自己申告による入院患者の病院食の摂取量とその関連要因に関する研究 en-subtitle= kn-subtitle= en-abstract=We examined patient's intake of meal and its relevant factors using a self-administered questionnaire. The 92 subjects of this study were patients in 1) post operational status with digestive diseases, 2) therapeutic conditions with digestive diseases, 3) therapeutic conditions with hemopathy, and 4) therapeutic conditions with kidney and endocrine diseases. All patients were hospitalized for more than a week. The results demonstrate that: 1) approximately 40% of the patients ate less than half of the patient meal; 2) patient's intake of meal was significantly related to pleasure of meal time and satisfaction of hospital food service; and 3) patient's intake of meal was strongly affected by the applied treatment and the symptoms in the patient; and 4) there was no significant correlation between patient's intake of meal and dietary knowledge, interest, action and benefit. kn-abstract=岡山大学医学部附属病院に入院中で,主に消化器系の疾患を持ち手術を受けた患者,主に消化器内で治療中の患者,主に血液内科で治療前･治療中の患者,主に腎･内分泌内科など慢性疾患の治療を受けている患者で,1週間以上入院しており,了承の得られた92名の患者を対象に,自己申告による病院食の摂取量とその関連要因について調査した結果以下の4点が明らかになった｡ 1.病院食の摂取量が半分以下であると答えた患者は約40%であった｡ 2.病院食の摂取量は,治療方法,身体症状と強い関連がみられた｡ 3.病院食の摂取量が多い者は食事の時間を楽しく感じ,食事にも満足していた｡ 4.食事に対する知識･興味･行動･有益性と病院食の摂取量との間には有意な関係はみられなかった｡ en-copyright= kn-copyright= en-aut-name=KataokaTetsuya en-aut-sei=Kataoka en-aut-mei=Tetsuya kn-aut-name=片岡徹也 kn-aut-sei=片岡 kn-aut-mei=徹也 aut-affil-num=1 ORCID= en-aut-name=SumiyoshiKazuko en-aut-sei=Sumiyoshi en-aut-mei=Kazuko kn-aut-name=住吉和子 kn-aut-sei=住吉 kn-aut-mei=和子 aut-affil-num=2 ORCID= en-aut-name=KawataChieko en-aut-sei=Kawata en-aut-mei=Chieko kn-aut-name=川田智恵子 kn-aut-sei=川田 kn-aut-mei=智恵子 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部･歯学部附属病院 affil-num=2 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 affil-num=3 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 en-keyword=病院食の摂取量 (patient's intake of meals) kn-keyword=病院食の摂取量 (patient's intake of meals) en-keyword=身体症状 (the symptoms in the patient) kn-keyword=身体症状 (the symptoms in the patient) en-keyword=食事の満足度 (satisfaction of patient food service) kn-keyword=食事の満足度 (satisfaction of patient food service) en-keyword=給食サービスの評価 (evaluation of patient food service) kn-keyword=給食サービスの評価 (evaluation of patient food service) END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue=1 article-no= start-page=1 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20031225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Recent trend of research on the nongenotoxic mechanisms of chemical carcinogenesis kn-title=化学発がんの非遺伝毒性的メカニズムの解明に関する最近の動向 en-subtitle= kn-subtitle= en-abstract=To elucidate the health effects by low dose radiation, we reviewed the recent trend of research on the epigenetic mechanisms of chemical carcinogenesis. The following view were obtained. It has become apparent that chemical and physical agents that induce cancer may do so through different cellular and molecular mechanisms. Investigators, recognizing the apparent differences in the ways compounds participate in the carcinogenesis process, coined the phrases "genotoxic" and "epigenetic" in describing activities of chemicals and physical agents that induced cancer. The term "nongenotoxic" has to some extent replaced "epigenetic" and thus, classification of chemical carcinogens has been frequently delegated to either the genotoxic or nongenotoxic categories. Moreover, while much work remains in the understanding of the modes and mechanisms of action of nongenotoxic carcinogens and the epigenetic effects of these agents, it is apparent that this category of chemicals are functionally different than those compounds which directly interact, mutate, and modify genomic DNA. kn-abstract=本総説は,筆者らが進めている｢低線量放射線の健康への影響と医療への応用｣に関する研究に資するために調査した,化学発がんの非遺伝毒性的メカニズムの解明に関する最近の動向の概要についてまとめたものである｡即ち,非遺伝毒性的発がんにおける細胞増殖,シトクロムP450誘導,酸化的ストレス,および遺伝子発現のそれぞれの役割,並びに量的な応答性について言及した｡また,後成的発がんにおけるアポトーシス,およびギャップ結合による情報伝達のそれぞれの役割についても触れた｡その結果,非遺伝毒性的な発がん物質の作用の様式とメカニズムやこれによる後成的な影響などについては解明さ れつつあり,特に,これらの発がん物質がゲノムDNAに対し直接的な相互作用,突然変異,修飾などを行う発がん物質とは機能的に異なった作用をすることが明らかになった｡また,これらは放射線発がんなど低線量放射線の健康への影響などについて研究する上で,重要な知見となっていることもわかった。 en-copyright= kn-copyright= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name=山岡聖典 kn-aut-sei=山岡 kn-aut-mei=聖典 aut-affil-num=1 ORCID= en-aut-name=HanamotoKatsumi en-aut-sei=Hanamoto en-aut-mei=Katsumi kn-aut-name=花元克巳 kn-aut-sei=花元 kn-aut-mei=克巳 aut-affil-num=2 ORCID= en-aut-name=InaYasuhiro en-aut-sei=Ina en-aut-mei=Yasuhiro kn-aut-name=稲恭宏 kn-aut-sei=稲 kn-aut-mei=恭宏 aut-affil-num=3 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name=片岡隆浩 kn-aut-sei=片岡 kn-aut-mei=隆浩 aut-affil-num=4 ORCID= en-aut-name=KawabeAtsusi en-aut-sei=Kawabe en-aut-mei=Atsusi kn-aut-name=川辺睦 kn-aut-sei=川辺 kn-aut-mei=睦 aut-affil-num=5 ORCID= en-aut-name=SanoMasanobu en-aut-sei=Sano en-aut-mei=Masanobu kn-aut-name=佐野正展 kn-aut-sei=佐野 kn-aut-mei=正展 aut-affil-num=6 ORCID= en-aut-name=UjifukuAyako en-aut-sei=Ujifuku en-aut-mei=Ayako kn-aut-name=氏福亜矢子 kn-aut-sei=氏福 kn-aut-mei=亜矢子 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部保健学科放射線技術科学専攻 affil-num=2 en-affil= kn-affil=岡山大学医学部保健学科放射線技術科学専攻 affil-num=3 en-affil= kn-affil=電力中央研究所低線量放射線研究センター affil-num=4 en-affil= kn-affil=岡山大学大学院保健学研究科保健学専攻修士課程 affil-num=5 en-affil= kn-affil=岡山大学大学院保健学研究科保健学専攻修士課程 affil-num=6 en-affil= kn-affil=岡山大学大学院保健学研究科保健学専攻修士課程 affil-num=7 en-affil= kn-affil=岡山大学大学院保健学研究科保健学専攻修士課程 en-keyword=化学発がん (chemical carcinogenesis) kn-keyword=化学発がん (chemical carcinogenesis) en-keyword=非遺伝毒性 (nongenotoxicity) kn-keyword=非遺伝毒性 (nongenotoxicity) en-keyword=後成説 (epigenesis) kn-keyword=後成説 (epigenesis) en-keyword=酸化的ストレス (oxidative stress) kn-keyword=酸化的ストレス (oxidative stress) en-keyword=ギャップ結合 (gap junction) kn-keyword=ギャップ結合 (gap junction) END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue= article-no= start-page=40 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=n-3系脂肪酸食の気管支喘息に対する臨床効果:n-6系脂肪酸との比較 kn-title=The clinical effects of dietary supplementation with n-3 fatty acids in bronchial asthma compared with n-6 fatty acids. en-subtitle= kn-subtitle= en-abstract=気道への炎症性白血球の集合が気管支喘息の病態に関わっている。魚油などのn-3系脂肪酸が白血球の機能を抑制することにより気管支喘息患者に良好な効果をもたらし,薬剤の必要性を減じたとの報告がなされている｡α-リレノン酸を豊富に含有するエゴマ油食の効果を調べるため,気管支喘息患者23名に2コースの食事-リノール酸の豊富なコーン油食を2週間摂取後,エゴマ油食を2週間-を摂取してもらった｡喘息患者は2コースの食事間のロイコトリエンB4(LTB4),CA(LTC4),B5(LTB5)の変化から2群-1群は食事に対し感受性のある群,もう1つは感受性の無い群-に分類した｡我々はこの2群を臨床的に検討したところ,ピークフロー(PEF),1秒量(FEV10),IgE,性別,肥満率(OⅠ),血清総コレステロール,アルブミン,低比重リポ蛋白(LDL)-コレステロール,β-リポ蛋白,リン脂質において2群間に有意差が認められた｡今回の研究から,これらの因子が,喘息患者において,LTB4,LTC4,LTB5の産生に対する食事療法の効果に影響を及ぼしていることが示唆された｡ kn-abstract=N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma by suppressing leukocyte function, followed by reduction of the need for pharmacologic agents. To examine the effects of dietary supplementation with perilla seed oil rich in α-linolenic acid (ALA), 23 patients with　asthma took corn oil rich in linoleic acid (LA) for the former two weeks, perilla seed oil for the later two weeks. The asthmatic patients were classified into two groups by the changes of the generation of leukotrienes B4 (LTB4), C4 (LTC4), and B5 (LTB5) during the two courses of dietary modification: one was sensitive to dietary modification, and the other was insensitive to dietary supplementation. We compared the two groups in clinical characteristics. Significant differences were observed in peak flow (PEF), forced expiratory volume in one second (FEV1.0), IgE, sex, obesity index (OI), concentration of serum total cholesterol, albumin, low density lipoprotein {LDL)-cholesterol, β-lipoprotein and phospholipids between two groups. This study indicated that these factors influence the generation of LTB4, C4 and B5 of asthmatic patients in dietary supplementation. en-copyright= kn-copyright= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=1 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=HaradaSeishi en-aut-sei=Harada en-aut-mei=Seishi kn-aut-name=原田誠之 kn-aut-sei=原田 kn-aut-mei=誠之 aut-affil-num=7 ORCID= en-aut-name=YumotoEiichiro en-aut-sei=Yumoto en-aut-mei=Eiichiro kn-aut-name=湯本英一朗 kn-aut-sei=湯本 kn-aut-mei=英一朗 aut-affil-num=8 ORCID= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=9 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=10 ORCID= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name=片岡幹男 kn-aut-sei=片岡 kn-aut-mei=幹男 aut-affil-num=11 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=11 en-affil= kn-affil=岡山大学医学部第二外科 affil-num=12 en-affil= kn-affil=岡山大学医学部第二外科 en-keyword=n-3系脂肪酸 (n-3 fatty acids) kn-keyword=n-3系脂肪酸 (n-3 fatty acids) en-keyword=エゴマ油 (perilla seed oil) kn-keyword=エゴマ油 (perilla seed oil) en-keyword=気管支喘息 (bronchial asthma) kn-keyword=気管支喘息 (bronchial asthma) en-keyword=LTB4 kn-keyword=LTB4 en-keyword=LTC4 kn-keyword=LTC4 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=43 end-page=52 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息患者における白血球ロイコトリエン産生能に対する不飽和脂肪酸食の効果に影響する因子 kn-title=Factors influencing the effects of dietary supplementation　with PUFAs on leukotriene generation by leucocytes in　patients with asthma en-subtitle= kn-subtitle= en-abstract=a-リノレン酸の豊富なエゴマ油の食事は気管支喘息患者の白血球ロイコトリエン(LT)産生能を抑制する｡気管支喘息患者の内,エゴマ油食によりLTC4の産生が抑制された群(A群)と抑制されない群(B群)の臨床データを比較することにより,気管支喘息患者の白血球ロイコトリエン産生能に影響する因子を検討した｡A群はコーン油(n-6系脂肪酸)の豊富な食事後,白血LTB4,LTC4の産生能が増加し,エゴマ油(n-3系脂肪酸)の豊富な食事後LTB4,LTC4の産生能が減少した｡これらの変化はB群では認められなかった｡A群のIgE値,ピークフロー(PEF)値はB群に比し,有意に高値であった｡またLDL-コレステロール,β-リポ蛋白,リン脂質はA群ではB群に比し,有意に低値であった｡これらの結果はエゴマ油の豊富な食事のn-3系脂肪酸によるLTB4,LTC4の産生能の抑制に関して2群の気管支喘息患者群間に臨床データの相違があることを示唆している｡ kn-abstract=Dietary supplementation with perilla seed oil, a vegetable oil rich in α -lin- olenic acid, inhibits the generation of leukotrienes(LTs) by leucocytes in patients with bronchial asthma. We examined the factors that affect the suppression of LT generation by leucocytes with perilla seed oil-rich supplementation in patients with asthma, by comparing the clinical features of patients with asthma, whose generation of leukotriene (LT) C4 was suppressed by dietary supplementation with perilla seed oil (n-3 fatty acids) (group A), with those of patients who showed no suppression of LTC4 generation (group B). Group A showed a significant increase in the generation of LTB4 and L TC4 by leucocytes after corn oil-rich supplementation (n-6 fatty acids), and a significant decrease in the generation of LTB4 and LTC4 after perilla seed oil-rich supplementation (n-3 fatty acid). However, this was not observed in group B. The level of serum IgE and peak expiratory flow (PEF) in group A were significantly higher than in group B. Furthermore, the serum levels of LDL-cholesterol, β-lipoprotein and　phospholipid were significantly lower in group A than in group B. These results suggest that the clinical features differ between these two asthmatic populations with respect to suppression of LTB4 and LTC4 generation by n-3 fatty acids in perilla seed oil-rich supplementation. en-copyright= kn-copyright= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=1 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=2 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=HaradaSeishi en-aut-sei=Harada en-aut-mei=Seishi kn-aut-name=原田誠之 kn-aut-sei=原田 kn-aut-mei=誠之 aut-affil-num=7 ORCID= en-aut-name=TakadaShingo en-aut-sei=Takada en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name=片岡幹男 kn-aut-sei=片岡 kn-aut-mei=幹男 aut-affil-num=10 ORCID= en-aut-name=NiiyaKenji en-aut-sei=Niiya en-aut-mei=Kenji kn-aut-name=新谷憲治 kn-aut-sei=新谷 kn-aut-mei=憲治 aut-affil-num=11 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=11 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=12 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=エゴマ油 (perilla seed oil) kn-keyword=エゴマ油 (perilla seed oil) en-keyword=気管支喘息 (bronchial asthma) kn-keyword=気管支喘息 (bronchial asthma) en-keyword=ロイコトリエン (leukotrienes) kn-keyword=ロイコトリエン (leukotrienes) en-keyword=IgE kn-keyword=IgE en-keyword=脂質代謝 (lipometabolism) kn-keyword=脂質代謝 (lipometabolism) END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue= article-no= start-page=60 end-page=65 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080301 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=IgG4-related disease kn-title=IgG4関連疾患 en-subtitle= kn-subtitle= en-abstract=IgG4-related disease is a new concept which was established in 21st century. Histologically, infiltrations of IgG4-positive plasma cells and lymphocytes occur in the lacrimal gland, salivary gland , retroperitoneum , pancreas , and biliary tract. IgG4-related disease is a systematic disease presenting symptoms such as Mikulicz's disease, retroperitoneal fibrosis, autoimmune pancreatitis, diabetes and sclerotic cholangitis, and oral steroid therapy is effective. In this paper, we propose diagnostic criteria for IgG4-related disease that have not been established yet. If two (or more) of three following features are fulfilled, IgG4-related disease is diagnosed ； elevated levels of serum IgG4, involvement of organs which is characteristic in IgG4-related disease (salivary gland, lacrimal gland, pancreas and retroperitonium) ,histological findings with IgG4-positive plasma cells and lymphocytes. kn-abstract=IgG4関連疾患は21世紀になって提唱された新しい疾患である｡組織学的にはIgG4陽性形質細胞やリンパ球浸潤が涙腺, 唾液腺, 後腹膜, 膵臓, 胆管などで起こり, 臨床的にはMikulicz病, 後腹膜線維症, 自己免疫膵炎, 糖尿病, 原発性硬化性胆管炎類似の胆管病変などを呈する全身性疾患であり, ステロイド治療に対する良好な反応性を認める｡その診断基準は確立されておらず, われわれは, ①血清IgG4の高値, ②本疾患に特徴的な臓器の障害(唾液腺,涙腺, 膵臓, 後腹膜), ③組織学的にIgG4陽性形質細胞とリンパ球の浸潤の確認, の３項目のうち２項目以上認めれば, IgG4関連疾患とするという診断基準を提言する｡ en-copyright= kn-copyright= en-aut-name=HiramatsuKazuhisa en-aut-sei=Hiramatsu en-aut-mei=Kazuhisa kn-aut-name=平松万尚 kn-aut-sei=平松 kn-aut-mei=万尚 aut-affil-num=1 ORCID= en-aut-name=AsanoMotoi en-aut-sei=Asano en-aut-mei=Motoi kn-aut-name=浅野基 kn-aut-sei=浅野 kn-aut-mei=基 aut-affil-num=2 ORCID= en-aut-name=MatsushitaKoki en-aut-sei=Matsushita en-aut-mei=Koki kn-aut-name=松下公紀 kn-aut-sei=松下 kn-aut-mei=公紀 aut-affil-num=3 ORCID= en-aut-name=MiyoshiTomoko en-aut-sei=Miyoshi en-aut-mei=Tomoko kn-aut-name=三好智子 kn-aut-sei=三好 kn-aut-mei=智子 aut-affil-num=4 ORCID= en-aut-name=NakamuraSukio en-aut-sei=Nakamura en-aut-mei=Sukio kn-aut-name=中村好男 kn-aut-sei=中村 kn-aut-mei=好男 aut-affil-num=5 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=6 ORCID= en-aut-name=KoideNorio en-aut-sei=Koide en-aut-mei=Norio kn-aut-name=小出典男 kn-aut-sei=小出 kn-aut-mei=典男 aut-affil-num=7 ORCID= en-aut-name=KataokaHitomi en-aut-sei=Kataoka en-aut-mei=Hitomi kn-aut-name=片岡仁美 kn-aut-sei=片岡 kn-aut-mei=仁美 aut-affil-num=8 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=9 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=2 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=3 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=4 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=5 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=6 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=7 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=8 en-affil= kn-affil=岡山大学医療教育統合開発センター affil-num=9 en-affil= kn-affil=岡山大学医療教育統合開発センター affil-num=10 en-affil= kn-affil=岡山大学病院三朝医療センター en-keyword=IgG4関連疾患 (IgG4-related disease) kn-keyword=IgG4関連疾患 (IgG4-related disease) en-keyword=自己免疫膵炎 (autoimmune pancreatitis) kn-keyword=自己免疫膵炎 (autoimmune pancreatitis) en-keyword=Mikulicz病 (Mikulicz's disease) kn-keyword=Mikulicz病 (Mikulicz's disease) en-keyword=後腹膜線維症 (retroperitoneal fibrosis) kn-keyword=後腹膜線維症 (retroperitoneal fibrosis) END start-ver=1.4 cd-journal=joma no-vol=121 cd-vols= no-issue=1 article-no= start-page=35 end-page=40 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Supporting female physicians in career development : Activity report on MEXT-supported projects and our future plans kn-title=女性医師のキャリア支援　Ｈ19文部科学省社会的ニーズに対応した質の高い医療人養成推進プログラム（医療人 GP）選定　「女性を生かすキャリア支援計画」の活動報告と今後 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaHitomi en-aut-sei=Kataoka en-aut-mei=Hitomi kn-aut-name=片岡仁美 kn-aut-sei=片岡 kn-aut-mei=仁美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部病院　卒後臨床研修センター，キャリアセンター（医療人 GP 事務局） en-keyword=女性医師 kn-keyword=女性医師 en-keyword=キャリア kn-keyword=キャリア en-keyword=復職支援 kn-keyword=復職支援 en-keyword=シミュレーショントレーニング kn-keyword=シミュレーショントレーニング en-keyword=屋根瓦式サポート kn-keyword=屋根瓦式サポート END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=9-10 article-no= start-page=1097 end-page=1102 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on alveolar macrophage function in interstitial lung disease Part 2. Abnormalities of alveolar macrophages in sarcoidosis and the correlations with clinical findings kn-title=間質性肺疾患における肺胞マクロファージに関する研究　第2編　サルコイドーシスにおける肺胞マクロファージ活性と疾患活動性との比較について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Several abnormalities of alveolar macrophage function were found in patients with sarcoidosis, and such abnormalities reflected the recruitment of immature macrophages to the local sites. In this study, alveolar macrophage function was compared with the disease activity in patients with sarcoidosis. The alveolar macrophage phagocytic index correlated closely with the spleen index obtained by ultrasonography, but not with serum angiotensin converting enzyme levels, lung function tests, or the cell differentiations of bronchoalveolar lavage fluid. The patients who had a positive uptake of 67-gallium scintigram showed a higher phagocytic index and a higher percentage of CD15-positive alveolar macrophages than those with negative scintigrams. Acid phosphatase activity and the percentage of CD15-positive alveolar macrophages were increased in patients with negative PPD skin tests compared to those with positive tests. We previously reported that alveolar lymphocytes in patients with sacroidosis are sensitized to Propionibacterium acnes (P. acnes), which may play a significant role in the induction of alveolitis in these patients. There was a significant correlation between the blastogenesis of alveolar lymphocytes induced by P. acnes and beta-galactosidase activity as well as the percentage of CD14-positive alveolar macrophages. These findings suggest that alveolar macrophages play an important role in the pathogenesis of sarcoidosis, in which the clinical abnormalities may reflect abnormal alveolar macrophage function. en-copyright= kn-copyright= en-aut-name=HosoyaShigee en-aut-sei=Hosoya en-aut-mei=Shigee kn-aut-name=細谷茂衛 kn-aut-sei=細谷 kn-aut-mei=茂衛 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=alveolar macrophage kn-keyword=alveolar macrophage en-keyword=sarcoidosis kn-keyword=sarcoidosis en-keyword=Propionibacterium acnes kn-keyword=Propionibacterium acnes en-keyword=lymphocyte blastgenesis kn-keyword=lymphocyte blastgenesis END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=9-10 article-no= start-page=1089 end-page=1095 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on alveolar macrophage function in interstitial lung disease Part 1. Abnormalities of alveolar macrophage functions kn-title=間質性肺疾患における肺胞マクロファージに関する研究　第1編　肺胞マクロファージの機能，胞体内ライソゾーム酵素活性，膜表面抗原の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Interstitial lung diseases comprise a heterogeneous group of disorders that are characterized by the chronic accumulation of inflammatory and immune effector cells within the alveoli, where they produce alveolitis, granulomas, or fibrosis. To investigate the pathogenesis of these diseases, the fucntions of alveolar macrophages recovered from bronchoalveolar lavage were evaluated in patients with interstitial lung disease in comparison to healthy controls. Thirty six patients were investigated : 18 with sarcoidosis, 6 with idiopathic interstitial pneumonia (IIP), 5 with interstitial pneumonia associated with collagen vascular disease (IP-CVD), and 7 with hypersensitivity pneumonitis (HP). Both the chemotactic and phagocytic indices were significantly higher in the patients with sarcoidosis, IIP, and HP than in the healthy subjects. However, the patients with IP-CVD had a lower phagocytic index than the normal subjects. Acid phosphatase activity was lower in patients with IIP, IP-CVD, and HP compared with the healthy subjects, while beta-galactosidase activity was lower in patients with sarcoidosis and IP-CVD compared with the normal controls. Analysis of surface markers showed that CD15-positive macrophages were increased in patients with sarcoidosis, IIP, and HP, but there were no differences in CD14- and HLA-DR-positive macrophages in these patients when compared to the healthy subjects. These findings indicate that the recruitment of peripheral blood monocytes to the lungs is increased in patients with sarcoidosis, IIP, and HP. Alveolar macrophages may play an important role in the pathogenesis of intersitial lung disease. en-copyright= kn-copyright= en-aut-name=HosoyaShigee en-aut-sei=Hosoya en-aut-mei=Shigee kn-aut-name=細谷茂衛 kn-aut-sei=細谷 kn-aut-mei=茂衛 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=alveolar macrophage kn-keyword=alveolar macrophage en-keyword=chemotaxis kn-keyword=chemotaxis en-keyword=phagocytosis kn-keyword=phagocytosis en-keyword=lysosomal enzyme kn-keyword=lysosomal enzyme en-keyword=intersitial lung disease kn-keyword=intersitial lung disease END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=259 end-page=266 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental and clinical studies on interferon and its inducers Part 2. β-carboxyethylgermanium sesquioxide (Ge-132) in the management of acute nonlymphocytic leukemia patients at remission phase kn-title=インターフェロン並びにインターフェロン誘発剤に関する基礎的・臨床的研究　第2編　急性非リンパ性白血病寛解期における β-Carboxyethylgermanium sesquioxide (Ge-132) の臨床効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The clinieal of Ge-132 in the management of acute nonlymphocytic leukemia (ANLL) patients at remission phase were studied. Twenty-two ANLL patients with complete remission were randomized into Groups A and B. Patients in Group A were treated with the combianation with Ge-132 (2,250mg/day ; p. o daily) and intermittent-alternating chemotherapy 〔daunorubicin, vincristine, cytosine arabinoside and prednisolone (DVCP)/aclarubicin vincristine cytosine arabinoside and prednisolone (AVCP)〕and patients in Groyp B were treated with intermittent-alter nating chemotherapy (DVCP/AVCP) alone. Evaluable patients were 7 in Group A and 10 in Group B. Remission duration and survival time were not significantly different between Groups A and B. (median remission duration ; 5.7 month in Group A vs 8.1 month in Group B/median surival time ; 23.9month in Group A vs 18.3month in Group B) The rates of second remission in relapsed cases were not significantly different between Groups A and B.〔2 of 7,(28.6%) in Group A vs 3 of 10,(30.0%) in B〕Ge-132 did not accelerate the recovery from myelosuppression after intensification with the DVCP regimen. The incidence of liver damage and levels of serum GOT and GPT tended to be lower in Group A than in Group B. In this clinical study the incidence of liver damage tended to be lowere in patients treated with Ge-132. The liver damage which often develops during intensificantion chemotherapy, not only limits the chemotherapy but also causes adverse effects on the quality of life of the patient. In part 1 of this series, Ge-132 was reported to activate the neutrophil chemiluminescence. Ge-132 seems to be useful in the management of ANLL patients not only by the enhancement of the host defense system but also by the prevenation of liver damage. en-copyright= kn-copyright= en-aut-name=FukumotoMitsuhiro en-aut-sei=Fukumoto en-aut-mei=Mitsuhiro kn-aut-name=福本光宏 kn-aut-sei=福本 kn-aut-mei=光宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Ge-132 kn-keyword=Ge-132 en-keyword=Biological response modifier kn-keyword=Biological response modifier en-keyword=Acute nonlymphocytic leukemia kn-keyword=Acute nonlymphocytic leukemia en-keyword=Immunotherapy kn-keyword=Immunotherapy END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=129 end-page=136 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on pulmonary granuloma formation by Propionibacterium acnes in sarcoidosis Part 2. Interleukin-2 production and responsiveness to Interleukin-2 of alveolar lymphocytes stimulated in experimental pulmonary granulomatosis produced by Propionibacterium acnes kn-title=サルコイドーシスの肺肉芽腫形成に対する Propionibacterium acens の関与に関する研究　第2編　Propionibacterium acens による実験的肺肉芽腫症における肺胞リンパ球の Interleukin-2 産生及び Interleukin-2　受容体発現のついて en-subtitle= kn-subtitle= en-abstract= kn-abstract=The role of Propionibacterium acnes (P. acnes) isolated from a high percentage of patients with sarcoidosis by Dr. Honnma, as a cause of sarcoidosis was examined. Interleukin-2 (IL-2) production and the responsiveness to IL-2 of alveolar lymphocytes stimulated by P. acnes were examined in vitro in a guinea pig model. The animals were divided into 4 groups, normal guinea pigs (group 1), guinea pigs intracutaneously presensitized with P. acnes and intratracheally challenged by saline (group 2), guinea pigs presensitized as above and intratracheally challenged with P. acnes (group 3), and guinea pigs presensitized as above and intratracheally challenged by P. acnes-pyridine extract residue (P. acnes-PER)(group 4). The production of IL-2 by alveolar lymphocytes stimulated by P. acnes-PER for 48 hours was determined using the method described by Gillis et al. The responsiveness of alveoloar lymphocytes to IL-2 was evaluated by 3H-TdR uptake in the presence and absence of P. acnes-PER. The amount of IL-2 produced by alveolar lymphocytes was 0.6±1.1, 0.7±1.1, 21.2±27.9 and 329.4±294.1 u/ml (M±SD), respectively, in groups 1, 2, 3 and 4. The value of IL-2 production in groups 3 and 4, the intratracheally challenged groups, was significantly higher htna that in groups 1 and 2, the control groups (p<0.02, p<0.01). By contrast, the IL-2 production of peripheral lymphocytes in groups 1, 2, 3 and 4 was 0, 7.4±10.3, 8.6±15.7 and 9.3±8.9 u/ml, respectively. The amount of IL-2 produced was about one-tenth thar of alveolar lymphocytes. In the intratracheally challenged groups, the responsiveness to IL-2 of alveolar lymphocytes in the presence and absence of P. acnes-PER was 12,514±12,766 and 6,611±7,066 for group 3, and 12,362±9,414 and 5,818±5,494 dpm, respectively, for group 4. The responsiveness to IL-2 of alveolar lymphoctyes in group 4 was signifincantly increased by stimulation with P. acnes-PER (p<0.05), but that in groups 1 and 2, control groups, was not different. Our findings indicate that P. acnes-PER stimulated IL-2 production from alveolar lymphocytes and induced a functionally active state of alveolar lymphocytes to IL-2 in this guinea pig model. In conclusion, the role of alveolar lymphocytes in an animal model stimulated by P. acnes appears to be consistent with that obtained on the sarcoidosis patients we previously reported. en-copyright= kn-copyright= en-aut-name=MoriYoshihiro en-aut-sei=Mori en-aut-mei=Yoshihiro kn-aut-name=森由弘 kn-aut-sei=森 kn-aut-mei=由弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=experimental pulmonary granulomatosis kn-keyword=experimental pulmonary granulomatosis en-keyword=guinea pig kn-keyword=guinea pig en-keyword=Propionibacterium acens kn-keyword=Propionibacterium acens en-keyword=Interleukin-2 kn-keyword=Interleukin-2 en-keyword=Interleukin-2 receptor kn-keyword=Interleukin-2 receptor END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=9-10 article-no= start-page=915 end-page=922 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Development of double cancer in small cell lung cancer patients treated with intensive chemotherapy kn-title=肺小細胞癌化学療法実施例における重複癌の発生に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Development of double cancer was evaluated in 337 small cell lung cancer patients who had received intensive chemotherapy with or without radiotherapy. Of them, 14 patients (4.2%) developed a second malignancy: non-small cell lung cancer in six, stomach cancer in four, acute myelogenous leukemia in two, liver cancer in one, and esophagus cancer in one. The relative risk for the development of double cancer calculated by person-year method utilizing age and sex adjusted cancer incidence in Japan was 2.75-fold (P<0.01). The risk of non-small cell lung cancer (8.75-fold) and acute myelogenous leukemia (37.82-fold) was particularly high. The cumulative risk for the development of double cancer was 2.0% at 1 year, 4.1% at 2 years, 14.3% at 3 years, and 100% at 8.1 years. Of 27 patients who survived disease-free for more than 2 years, 10 patients died; five patients (50%) died of double cancer, two died of infectious disease, and only three patients died from recurrent small cell lung cancer. These findings indicate that a cautious follow-up program for the detection of double cancer is indicated in patients with small cell lung cancer. en-copyright= kn-copyright= en-aut-name=MiyakeKenichi en-aut-sei=Miyake en-aut-mei=Kenichi kn-aut-name=三宅賢一 kn-aut-sei=三宅 kn-aut-mei=賢一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=肺小細胞癌 kn-keyword=肺小細胞癌 en-keyword=化学療法 kn-keyword=化学療法 en-keyword=重複癌 kn-keyword=重複癌 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=117 end-page=127 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on pulmonary granuloma formation by Propionibacterium acnes in sarcoidosis Part 1. Interleukin-2 production and receptor expression of alveolar lymphocytes stimulated by Propionibacterium acnes in sarcoidosis kn-title=サルコイドーシスの肺肉芽腫形成に対する Propionibacterium acens の関与に関する研究　第1編　サルコイドーシス肺胞リンパ球のPropionibacterium acens に対する Interleukin-2 産生及び Interleukin-2　受容体発現のついて en-subtitle= kn-subtitle= en-abstract= kn-abstract=We previously reported that alveolar lymophocytes in patients with active sarcoidosis are sensitized Propionibacterium acnes (P. acnes) which may play a significant role in the induction of alveolitis in these patients. We further investigated the production of Interleukin-2 (IL-2), and the responsiveness to IL-2 of alveolar lymphocytes obtained from sarcoidosis patients and stimulated by P. acnes in vitro. In 21 untreated sarcoidosis patients, 7 treated patients and 13 control subjects, the mean IL-2 activity of fluid released from cultured alveoloar lymphocytes was 9.8±15.7 (M±SD), 1.9±4.7 and 0.2±0.8 u/ml respectively. The IL-2 activity of lymphocytes from untreated patients was significantly higher than that of control subjects (p<0.02). Neither perioheral lymphocytes in sarcoidosis patients nor in controls produced IL-2 stimulated by P. acnes. The responsiveness of alveloar lymphocytes to recombinant IL-2 was evaluated by 3H-thymidine uptake in the presence and absence of P. acnes. Lymphocytes stimulated by P. acnes showed a significantly increased uptake (3,766±3,929 dpm) compred to ustimulated lymphocytes (1,123±968 dpm) obtained from 11 untreated sarcoidosis patients (p<0.02). On the other hand, the responsiveness of lymphocytes obtained from 6 control subjects was low regardless of stimulation by P. acnes. There was a significant correlation (p<0.05) between the P. acnes-induced production of IL-2 by alveolar lymphocytes and the blastogenesis of alveloar lymphocytes in untreated sarcoidosis patietnes. Our findings indicate that P. acnes stimulated IL-2 production and IL-2 receptor induction in alveolar lymphocytes from patients with active sarcoidosis. This study supported our hypothesis that P. acnes could be an antigen causing sarcoidosis. en-copyright= kn-copyright= en-aut-name=MoriYoshihiro en-aut-sei=Mori en-aut-mei=Yoshihiro kn-aut-name=森由弘 kn-aut-sei=森 kn-aut-mei=由弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=sarcoidosis kn-keyword=sarcoidosis en-keyword=Propionibacterium acens kn-keyword=Propionibacterium acens en-keyword=Interleukin-2 kn-keyword=Interleukin-2 en-keyword=Interleukin-2 receptor kn-keyword=Interleukin-2 receptor en-keyword=alveolar lymphocyte kn-keyword=alveolar lymphocyte END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=63 end-page=74 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical and radiological study of femoral neck fractures in patients with rheumatoid arthritis kn-title=慢性関節リウマチ患者における大腿骨頸部骨折の臨床的ならびにX線学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clinical and radiological studies were performed on 58 patients with rheumatoid arthritis (RA) who had sustained 64 femoral neck fractures. All but one patietns werre female, the mean age was 66.5 years, and mean duration of RA was 17 years. Only 3 hips showed rheumatoid changes. Sixteen fractures of 14 patietns were spontaneous fractures without trauma. Ipsilateral total knee replacements were performed on 5 patients with spontaneous fractures. Results of treatment were analyzed on 47 fractures in 43 patients that could be followed up for more than 1 year (mean 42 months). Clinical results were evaluated by ability of ambula-tion and complications such as nonunion and avascular necrosis of the femoral head. All 4 fractures treated conservatively and 5 of 9 displaced fractures treated by internal fixation developed complications. Femoral head replacements had a high rate of proximal migration (23.8%) and distal migration (76.2%), and ambulation ability was lowered significantly in 10 patients with distal migration for more than 5 mm. On the other hand, satisfactory results were obtained on all 6 fractures treated by total hip replacements (THR). THR is advisable for tratmetn of displaced femoral neck fracture in patients with RA. en-copyright= kn-copyright= en-aut-name=KawamuraMasahide en-aut-sei=Kawamura en-aut-mei=Masahide kn-aut-name=川村正英 kn-aut-sei=川村 kn-aut-mei=正英 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部整形外科学教室 en-keyword=慢性関節リウマチ kn-keyword=慢性関節リウマチ en-keyword=大腿骨頸部骨折 kn-keyword=大腿骨頸部骨折 en-keyword=spontaneous fracture kn-keyword=spontaneous fracture en-keyword=治療成績 kn-keyword=治療成績 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=21 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Antitumor effect of interferon-α, γ and/or tumor necrosis factor-α against human colon cancer line (LoVo) transplanted into nude mice kn-title=ヌードマウス可移植性ヒト大腸癌細胞株 LoVoに対する interferon-α,-γ, tumor necrosis factor-α の抗腫瘍効果の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We investigated the in vivo antitumor effect of recombinant human interferon-α,γ (IFN-α,γ) and/or recombinant human tumor necrosis factor-α (TNF-α) against human colon cancer cells (LoVo) transplanted into nude mice. LoVo cells were very sensitive to IFN-γ and slightly sensitive to IFN-α and resistant to TNF-α in vitro by dye uptake method. Intravenous administration of IFN-γ significantly inhibited tumor growth transplanted subcutaneously into nude mice, but IFN-α and/or TNF-α did not show any antitumor effect. Labeling index on stanining with bromodeoxyuridune and mitotic index of LoVo cells treated with IFN-α,γ or TNF-α differed slightly from those of the control group. We previously reported that the synergistic antitumor effects on the three cell lines could be examined by the combined use of IFN-α and TNF-α and the mechanism of the synergism was arrested in the S phase of cell cycle of target cells. However in the cese of LoVo cells, the combined use of IFN-α and TNF-α was not effective and did not arrest the cells in tha S phase of cell cycle. Therefore, arrest in the S phase was suspected to be responsible from the synergistic antitumor activity of IFN-α and TNF-α on the sensitive targets. en-copyright= kn-copyright= en-aut-name=KataokaKazuhiko en-aut-sei=Kataoka en-aut-mei=Kazuhiko kn-aut-name=片岡和彦 kn-aut-sei=片岡 kn-aut-mei=和彦 aut-affil-num=1 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=2 ORCID= en-aut-name=MuroMasahiko en-aut-sei=Muro en-aut-mei=Masahiko kn-aut-name=室雅彦 kn-aut-sei=室 kn-aut-mei=雅彦 aut-affil-num=3 ORCID= en-aut-name=KojimaKazushi en-aut-sei=Kojima en-aut-mei=Kazushi kn-aut-name=小島一志 kn-aut-sei=小島 kn-aut-mei=一志 aut-affil-num=4 ORCID= en-aut-name=HorikiSadayuki en-aut-sei=Horiki en-aut-mei=Sadayuki kn-aut-name=堀木貞幸 kn-aut-sei=堀木 kn-aut-mei=貞幸 aut-affil-num=5 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=6 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=7 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=nude mouse kn-keyword=nude mouse en-keyword=human colon cancer kn-keyword=human colon cancer en-keyword=interferon kn-keyword=interferon en-keyword=tumor necrosis factor kn-keyword=tumor necrosis factor en-keyword=cell cycle kn-keyword=cell cycle END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=493 end-page=503 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on malignant lymphoma Part 1. Second malignant neoplasms in patients with malignant lymphoma after chemotherapy kn-title=悪性リンパ腫の病態と治療に関する研究　第1編　悪性リンパ腫化学療法後の2次癌発症についての検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The risk of a second malignancy was analyzed in 23 patients with Hodgkin's disease (HD) and 177 with non-Hodgkin's lymphoma (NHL) who were initially treated with combination chemotherapy between 1976 and 1990. Among these patients, 3 cases of gastric cancer, 2 cases of lung cancer, 2 cases of hepatoma, one case of colon cnacer, one case of cholangiocarcinoma and one case of acute myeloblastic leukemia were subsequently observed. Median age at diagnosis of lymphoma was 64 years in patients who developed subsequent malignancies but was 9 years higher than that for the entire lymphoma group. Median interval from srart of chemotherapy to the appearance of second malignancy was 43.9 years and ranged from 1.9 years to 8.8 years. The 7-year cumulative risk of second malignancy in HD and NHL were 7.7% and 11.7%, respectively. In Hodgkin's disease, the incidence of stomach and lung cancers was significantly greater than expected incidence calculated on the basis of age-adjusted person-years. In non-Hodgkin's lymphoma, the incidence was also greater than expected for all malignancies except stomach cancer. This indicater that the incidence of solid malignancy as well as leukemia is higher in lymphoma patients after chemotherapy than in the general population. en-copyright= kn-copyright= en-aut-name=TagawaShinya en-aut-sei=Tagawa en-aut-mei=Shinya kn-aut-name=田川真也 kn-aut-sei=田川 kn-aut-mei=真也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=malignant lymphoma kn-keyword=malignant lymphoma en-keyword=chemotherapy kn-keyword=chemotherapy en-keyword=second primary malignancy kn-keyword=second primary malignancy END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=465 end-page=473 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Interleukin-1 production of alveolar macrophages in sarcoidosis kn-title=サルコイドーシスにおける肺胞マクロフｧージの Interleukin-1 産生に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The production of interleukin-1 (IL-1) in alveolar macrophages (AMs) was studied in 25 patients with sarcoidosis to inversigate the role of immune mechanisms in this disease. The radioimmunoassay (RIA) method was compared with the bioassay method for detecting IL-1 in the supernatants of AM cultures. The level of IL-1β measured by RIA was closely corrrelated with the IL-1 activity measured by bioassay (r=0.88, p<0.01). The amount of IL-1β in the supernatant of AM cultures from sarcoidosis patients was compared with those from control subjects. No significant IL-1β activity was detected in the culture supernatants of unstimulated AMs from either group of subjects. However, the production of IL-1β by AMs stimulated with Propionibacterium acnes (P. acnes) was significantly higher in patients with sarcoidosis than in controls (p<0.05). Lipopolysaccharide (LPS) induced increased IL-1β production by AMs from both sarcoidosis patients and controls compared to unstimulated or P. acnes-stimulated AMS, but the mean IL-1β level for sarcoidosis AMs did not differ from that for control AMs. There was no difference in the IL-1β production of peripheral blood monocytes between sarcoidosis patients and controls. These data suggest that AMs are activated in sarcoidosis and may modulate alveolar lymphocyte functions to play a critical role in the pathogenesis of the disease. en-copyright= kn-copyright= en-aut-name=HiokaTohru en-aut-sei=Hioka en-aut-mei=Tohru kn-aut-name=飛岡徹 kn-aut-sei=飛岡 kn-aut-mei=徹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=sarcoidosis kn-keyword=sarcoidosis en-keyword=interleukin-1 kn-keyword=interleukin-1 en-keyword=alveolar macrophage kn-keyword=alveolar macrophage END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=3-4 article-no= start-page=353 end-page=364 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of lung cancer with interstitial pneumonia Part 2. Interleukin-2 receptor in peripheral blood of lung cancer patients kn-title=肺癌のびまん性肺線維化病態に関する研究　第2編　肺癌における末梢血インターロイキン 2 レセプターの検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Interleukin-2 receptor (IL-2R) and lymphocyte subsets in peripheral blood were evaluated in patients with lung cancer. The level of sluble IL-2R (sIL-2R) in sera and the percentage of IL-2R positive lymphocytes in lung cancer patients were higher than that in normal subjects, but the lymphocytes reactivity to IL-2 was not different from that in normal subjects. There was no difference in the IL-2/IL-2R system of each histological type in patients with lung cancer. The serum sIL-2R level and the percentage of IL-2R positive lymphocytes increased in the advenced stage, but lymphocyte reactivity to IL-2 decreased. There was dissociation between expression of IL-2R and lymphocyte reactivity to IL-2 in lung cancer patients. Furthermore, serum sIL-2R level increased in relation to progression of fibrotic changes in lung cancer with interstitial pneumonia, although the percentage of IL-2R positive lymphocytes did not increase. Serum sIL-2R level showed no correlation with the percentage of IL-2R positive lymphocytes. These data suggest that the increased level of sIL-2R may be related to fibrotic changes in the lung and reflect the disorder of cellular immunity in lung cancer patients with interstitial pneumonia. en-copyright= kn-copyright= en-aut-name=ShibayamaTakuo en-aut-sei=Shibayama en-aut-mei=Takuo kn-aut-name=柴山卓夫 kn-aut-sei=柴山 kn-aut-mei=卓夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Lung cancer kn-keyword=Lung cancer en-keyword=Soluble interleukin-2 receptor kn-keyword=Soluble interleukin-2 receptor en-keyword=Interleukin-2 receptor positive lymphocyte kn-keyword=Interleukin-2 receptor positive lymphocyte en-keyword=Response to recombinant human interleukin-2 kn-keyword=Response to recombinant human interleukin-2 en-keyword=Interstitial pneumonia kn-keyword=Interstitial pneumonia END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=3-4 article-no= start-page=341 end-page=351 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of lung cancer with interstitial pneumonia Part 1. Analysis of the clinical features of intersitial pneumonia in lung cancer kn-title=肺癌のびまん性肺線維化病態に関する研究　第1編　肺癌に随伴するびまん性間質性陰影の臨床的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clinical features and findings on chest x-ray were analyzed to clarify the relationship between lung cancer and interstitial pneumonia. Of 262 patients with lung cancer, 69 patients (26.3%) had interstitial pneumonia. Patients with interstitial pneumonia (LC with IP) were older than those without interstitial pneumonia (LC without IP). The incidence of LC with IP cases among males and smokers were 29.2% and 29.3%, respectively. There were no significant differences among histlogic types and clinical stages of lung cancer. More cases of LC with IP had cancer in the lower (42.0%) and peripheral (76.8%) areas on chest x-ray films. Cancer was frequently located within the interstitial shadow on chest x-ray film. Among 40 patients with idiopathic interstitial pneumonia associated lung cancer (IIP with LC), there were 38 males and 32 smokers. No dominant histlogic subtype of lung cancer was noted in IIP with LC, though the most frequent was adenocarcinoma (16 cases, 40%). In IIP with LC, the site of cancer was associated with active fibrotic changes in interstitial pneumonia. These data strongly suggest that carcinogenic factors were related to the fibrotic changes in interstitial pneumonia. en-copyright= kn-copyright= en-aut-name=ShibayamaTakuo en-aut-sei=Shibayama en-aut-mei=Takuo kn-aut-name=柴山卓夫 kn-aut-sei=柴山 kn-aut-mei=卓夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Lung cancer kn-keyword=Lung cancer en-keyword=Idiopathic interstitial pneumonia kn-keyword=Idiopathic interstitial pneumonia en-keyword=Chest X-ray finding kn-keyword=Chest X-ray finding END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=349 end-page=357 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on cytokines produced by alveolar macrophages in the patients with sarcoidosis kn-title=サルコイドーシス患者肺胞マクロファージのサイトカイン産生能に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The role of cytokines produced from alveolar macrophages (AMs) in the compartmentalized T-cell activation in pulmonary sarcoidosis is poorly understood. Herein, we demonstrate the production of Interleukin-6 (IL-6) and tumor necrosis factor (TNF-α) by alveolar macro-phages from 36 patients with sarcoidosis and 26 normal subjects. Non-stimulated AMs from sarcoidosis patients spontaneously produced IL-6, as well as TNF-α. The spontaneous produc-tion of IL-6 was significantly increased in the patients with sarcoidosis than in the normal subjects, but not that of TNF-α. Furthermore, the amount of TNF-α and IL-6 produced from AMs stimulated by Propionibacterium acnes (P. acnes) or lipopolysaccharide was significantly increased in patients with asrcoidosis compared to the normal subjects. TNF-α production from AMs stimulated by P. acnes closely correlated to the IL-6 production from AMs stimulat-ed by P. acnes correlated to thr proportion of lymphocytes in the bronchoalveolar lavage fluid. These findings suggest that AMs are activated in sarcoidosis and that those cells produre IL-6 and TNF-α, which are responsible for T-cell activation. en-copyright= kn-copyright= en-aut-name=ShiomiKatsuhiko en-aut-sei=Shiomi en-aut-mei=Katsuhiko kn-aut-name=塩見勝彦 kn-aut-sei=塩見 kn-aut-mei=勝彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Interleukin-6 kn-keyword=Interleukin-6 en-keyword=Interleukin-1 kn-keyword=Interleukin-1 en-keyword=tumor necrois factor kn-keyword=tumor necrois factor en-keyword=alveolar macrophage kn-keyword=alveolar macrophage en-keyword=cytokine kn-keyword=cytokine en-keyword=sarocidosis kn-keyword=sarocidosis END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=3-4 article-no= start-page=317 end-page=322 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Hemodialysis membrane with a negative charge : Modeling glomerular basement membrane kn-title=腎糸球体基底膜をモデルとした理想的な透析膜作製に関する基礎的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The glomerular basement membrane (GBM) regulates protein permeability by acting as both a size barrier and charge barrier. Since heparan sulfate-proteoglycan (HS-PG) which forms the charge barrier of the GBM contains a sulfonic acid base, we prepared negatively charged membranes by adding a sulfonic acid base to EVAL (ethylene vinyl alcohol) membranes. The permeabilities os the various proteins in these membranes were compared with those of conventional neutrally charged EVAL membranes. The permselectivity for proteins of negatively charged EVAL membranes depends largely upon the interrelation between the pore size of the membranes and size of the proteins. The negatively charged EVAL membranes had a higher selective permeability than the conventional neutrally charged EVAL membranes. Therefore, a negative charge within the dialyzer might produce higher selective permeability than conventional dialyzers. en-copyright= kn-copyright= en-aut-name=NagakeYoshio en-aut-sei=Nagake en-aut-mei=Yoshio kn-aut-name=長宅芳男 kn-aut-sei=長宅 kn-aut-mei=芳男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第三内科学教室 en-keyword=透析膜 kn-keyword=透析膜 en-keyword=腎糸球体基底膜 kn-keyword=腎糸球体基底膜 en-keyword=size barrier kn-keyword=size barrier en-keyword=charge barrier kn-keyword=charge barrier en-keyword=スルホン酸基 kn-keyword=スルホン酸基 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=335 end-page=347 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ok-432-induced interferon-γ (IFN-γ) production in patients with malignant lymphoma kn-title=OK-432による悪性リンパ腫のinterferon-γ (IFN-γ)産生能に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=OK-432, a streptococcal preparatopn, is a potent inducer of interferon-γ (IFN-γ) which is known to modulate the immune response. The OK-432-induced IFN-γ production of peripheral blood mononuclear cells (PBMC) was examined in 98 patients with malignant lymphoma, The PBMC were incubated in RPMI-1640 containing 0.1KE/ml OK-432 for 48 hours and the IFN-γ secreted in the supernatant was measured thereafter. Patients at diagnosis or those with relapsing disease showed a decreased production of IFN-γ compared with the healthy controls (P<0.001). The production at diagnosis was related to the clinical stage. The production was significantly decreased immediately after multi-drug chemotherapy. However, it recovered to the level of the healthy controls, once a patient achieved a complete response. At diagnosis, 13 of the 32 patients with non-Hodgkin's lymphoma showed low IFN-γ production. These patients responded poorly to chemotherapy or had early relapse. The 2-year actuarial survival rate was 54% for these patients and 92% for the remainder. There was no decrease in IFN-γ production after chemotherapy in patients treated with G-CSF. These findings suggest that measurement of OK-432-induced IFN-γ production is useful for evaluating the immunological status and predicting the prognosis in patients with malignant lymphoma. They also suggest that G-CSF affects the IFN-γ production in vivo. en-copyright= kn-copyright= en-aut-name=SaitoSeiji en-aut-sei=Saito en-aut-mei=Seiji kn-aut-name=齋藤誠二 kn-aut-sei=齋藤 kn-aut-mei=誠二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Lymphoma kn-keyword=Lymphoma en-keyword=G-CSF kn-keyword=G-CSF en-keyword=Prognostic factor kn-keyword=Prognostic factor END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue=1 article-no= start-page=39 end-page=47 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20051231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Local wind storm (Hirodo-kaze) in northern Okayama caused by Typhoon 0421 & 0423 kn-title=2004年の台風による岡山県北部の暴風被害(広戸風)について en-subtitle= kn-subtitle= en-abstract= kn-abstract=In 2004, ten typhoons had landed over Japan and a lot of damages were reported due to heavy rain, storm surge and wind storms. In the north eastern part of Okayama prefecture, local high wind "Hirodo-kaze" caused severe wind damages due to typhoon passage. During Typhoon 0421, high winds were recoreded in the south foot of Mt.Nagi as typical local wind atrom, " Hirodo-kaze". While, during Typhoon 0423, severe wind damages expanded west of the typical Hirodo-kaze srea as well as a new extreme. In the present report, a lot of surface meteorological data were coollected and compared the meteorological fields among two typhoons. 　 en-copyright= kn-copyright= en-aut-name=KataokaFumie en-aut-sei=Kataoka en-aut-mei=Fumie kn-aut-name=片岡文恵 kn-aut-sei=片岡 kn-aut-mei=文恵 aut-affil-num=1 ORCID= en-aut-name=TsukamotoOsamu en-aut-sei=Tsukamoto en-aut-mei=Osamu kn-aut-name=塚本修 kn-aut-sei=塚本 kn-aut-mei=修 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University en-keyword=Wind Storm kn-keyword=Wind Storm en-keyword=Hirodo-kaze kn-keyword=Hirodo-kaze en-keyword=Typhoon kn-keyword=Typhoon en-keyword=Local high wind kn-keyword=Local high wind END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=7-8 article-no= start-page=665 end-page=671 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on alveolar lymphocyte proliferation induced by Propionibacterium acnes in sarcoidosis Part 2. Correlation between local lymphocyte response and clinical features in sarcoidosis kn-title=サルコイドーシス肺リンパ球の Propionibacterium acnes に対する反応性に関する研究 第2編 P. acnes に対する反応性と臨床検査との相関 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Alveolar lymphocyte response by Propionibacterium acnes (P. acnes) in patients with active sarcoidosis was previously reported by our group. The response of alveolar lymphocytes in 34 untreated patients with sarcoidosis was studied in correlation with clinical findings on radiographic, physiologic and bronchoalveolar lavage. There was a significant correlation between lymphocyte blastogenesis and the number of lymphocytes (p<0.05), and CD4(＋) T-cells (p<0.01) obtained by bronchoalveolar lavage. Furthermore, the response was significantly correlated with the activity of Interleukin-2 released by alveolar lymphocytes stimulated by P. acnes (p<0.05). In patients who showed abnormalities on all three clinical examinations, i. e. serum angiotensin converting enzyme activity, number of alveolar lymphocytes and 67Ga scintigraphy of the lung, the response was significantly higher than in the controls (p<0.001) or in patients with none of these abnormalities (p<0.01). These data suggest that the response of alveolar lymphocytes reflects the activity of pulmonary sarcoidosis. en-copyright= kn-copyright= en-aut-name=MaetaTsuyoshi en-aut-sei=Maeta en-aut-mei=Tsuyoshi kn-aut-name=前田剛 kn-aut-sei=前田 kn-aut-mei=剛 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Sarcoidosis kn-keyword=Sarcoidosis en-keyword=alveolar-lymphocyte kn-keyword=alveolar-lymphocyte en-keyword=P. acnes kn-keyword=P. acnes en-keyword=Angiotensin-converting enzyme kn-keyword=Angiotensin-converting enzyme en-keyword=Gallium-scintigraphy kn-keyword=Gallium-scintigraphy END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=7-8 article-no= start-page=657 end-page=663 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on alveolar lymphocyte proliferation induced by Propionibacterium acnes in sarcoidosis Part 1. Specificity of alveolar lymphocyte response to Propionibacterium acnes in sarcoidosis kn-title=サルコイドーシス肺リンパ球の Propionibacterium acnes に対する反応性に関する研究 第1編 P. acnes に対する反応の特異性に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The fact that alveolar lymphocytes in patients with active sarcoidosis are sensitized by Propionibacterium acnes (P. acnes) was previously reported by our group. Therefore, the responses of alveolar lymphocytes induced by Nocardia rubra and Streptococcus pyogenes were investigated and compared to those of P. acnes. The mean response rate of alveolar lymphocytes to P. acnes was significantly enhanced (1.89±1.45) in 12 untreated sarcoidosis patients compared with the response rates to Nocardia rubra (0.87±0.47) and Streptococcus pyogenes (0.64±0.30). Peripheral lymphocytes did not respond to any cell wall components of these organisms. Our findings indicate that alveolar lymphocytes in sarcoidosis are specifically sensitized by P. acnes, and suggest that P.acnes plays an important role in the induction of alveolar lymphocytes in sarcoidosis. en-copyright= kn-copyright= en-aut-name=MaetaTsuyoshi en-aut-sei=Maeta en-aut-mei=Tsuyoshi kn-aut-name=前田剛 kn-aut-sei=前田 kn-aut-mei=剛 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=sarcoidosis kn-keyword=sarcoidosis en-keyword=alveolar lymphocyte kn-keyword=alveolar lymphocyte en-keyword=blastogenesis kn-keyword=blastogenesis en-keyword=P. acnes kn-keyword=P. acnes END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=1-2 article-no= start-page=61 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Interleukin-2 receptor α(p55) mRNA expression in alveolar lymphocytes of patients with sarcoidosis kn-title=サルコイドーシス患者肺胞リンパ球のInterleukin-2 receptor α(IL-2R α) mRAの発現に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=T-lymphocytosis was detected in bronchoalveolar lavage fluid of patients with sarcoidosis. To clarify the mechanism of this phenomenon, interleukin-2 receptor(IL-2R) α gene expres-sion of lymphocytes recovered from bronchoalveolar lavage fluid was investigated in 8 patients with sarcoidosis and 5 healthy individuals, using reverse transcription polymerase chain reactin (RT-PCR). Cytoplasmic RNA derived from alveolar lymphocytes was reverse transcribed by RAV-2 reverse transcriptase to cDNA. The cDNA produced by reverse transcription was subjected to PCR. The primers of IL-2R α were utilized and a template derived from IL-2R mRNA was amplified by PCR. Southern blot analysis using 32P labeled cDNA probe for IL-2R α was performed followed by PCR. The intensities of IL-2R mRNA expression in Southern blot analysis were closely correlated to the cell numbers determined in RT-PCR. All patients with sarcoidosis had higher expression of IL-2R α mRNA transcript in alveolar lymphoctes compared with healty with healthy individuals. Moreover, the expression increased after stimulation by Propionibacterium acnes in 5 of 6 patents with sarcoidosis. These findings suggest that alvalar T-lymphocytes in the patients with sarcoidosis were actiated and played a central role in the pathogenesis of sarcoidosis. en-copyright= kn-copyright= en-aut-name=NishizakiHiroshi en-aut-sei=Nishizaki en-aut-mei=Hiroshi kn-aut-name=西崎浩 kn-aut-sei=西崎 kn-aut-mei=浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=sarcoidosis kn-keyword=sarcoidosis en-keyword=interleukin-2 receptor α kn-keyword=interleukin-2 receptor α en-keyword=reverse transcription-polymerase chain reaction kn-keyword=reverse transcription-polymerase chain reaction en-keyword=alveolar lymphocyte kn-keyword=alveolar lymphocyte en-keyword=Propionibacterium acnes kn-keyword=Propionibacterium acnes END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=7-8 article-no= start-page=751 end-page=756 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case report of esophageal cyst kn-title=食道囊腫の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Esophageal cyst is a relatively rare disease and about 91 cases have been reported in Japan. We report a new case of esophageal cyst. Tha patient was a 36-year-old male who complained of nausea and vomiting. We performed esophagography, endoscopy, endoxcopic echography, CT and MRI and found a cystic lesion in the lower esophagus. We made the diagnosis of an esophageal cyst and performed operation. The tumor was in the esophageal muscle but did not have a commissure to the esophageal lumen. We extirpated it with esophageal muscle and repaired the muscle defect with diaphragma. This tumor, 7.5×5.0cm in size, was a monolocular cyst and contained brown muddy material. Microscopic findings revealed a ciliated columnar epithelium and squamous epithelium in the cyst wall but cartilage was not found. The cyst was covered with double smooth muscle layers. It was difficult to differentiate an esophageal cyst from a paraesophageal bronchogenic cyst but these histological findings suggested that this cyst was an esophageal cyst. en-copyright= kn-copyright= en-aut-name=IshiiYasunori en-aut-sei=Ishii en-aut-mei=Yasunori kn-aut-name=石井泰則 kn-aut-sei=石井 kn-aut-mei=泰則 aut-affil-num=1 ORCID= en-aut-name=InoueFumiyuki en-aut-sei=Inoue en-aut-mei=Fumiyuki kn-aut-name=井上文之 kn-aut-sei=井上 kn-aut-mei=文之 aut-affil-num=2 ORCID= en-aut-name=BanHidetoshi en-aut-sei=Ban en-aut-mei=Hidetoshi kn-aut-name=伴秀利 kn-aut-sei=伴 kn-aut-mei=秀利 aut-affil-num=3 ORCID= en-aut-name=KamikawaYasuaki en-aut-sei=Kamikawa en-aut-mei=Yasuaki kn-aut-name=上川康明 kn-aut-sei=上川 kn-aut-mei=康明 aut-affil-num=4 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=食道囊腫 kn-keyword=食道囊腫 en-keyword=esophageal cyst kn-keyword=esophageal cyst en-keyword=気管支食道囊腫 kn-keyword=気管支食道囊腫 en-keyword=bronchial-esophageal cyst kn-keyword=bronchial-esophageal cyst en-keyword=foregut cyst kn-keyword=foregut cyst END start-ver=1.4 cd-journal=joma no-vol=108 cd-vols= no-issue=7-8 article-no= start-page=203 end-page=214 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Potential role of granulocyte colony stimulating factor in treating urinary tract infection kn-title=尿路感染症治療における Granulocyte Colony-Stimulating Factor (G-CSF) の有用性に関する基礎的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The priming effects of granulocyte colony stimulating factor (G-CSF) on neutrophil function and anti-pseudomonal activity were examined under various osmotic conditions created with urea and NaCL (280mOsm., 400mOsm., 800mOsm.) in vitro. Consequently, the prophylactic effect of G-CSF on post-operative urinary tract infection after transurethral resection of the prostate were examined experimentally. As a result, neutropil chemiluminescence was significantly enhanced by G-CSF under physiological osmotic conditions. However, enhancement was not observed under hyperosmotic conditions as in the urine. Similarly, the anti-pseudomonal activity of human neutrophils was not enhanced by G-CSF under hyperosmotic condition. However, whole blood chemiluminescence in patients after transurethral resection of the prostate was significantly enhanced by the administration of G-CSF. Moreover, postoperative urinary tract infection, considered an infection of the submucosal layer, was not obsereved, suggesting that the neutrophil priming effect occurred in the submucosal layer not in the urinary tract. en-copyright= kn-copyright= en-aut-name=HataKazuhiro en-aut-sei=Hata en-aut-mei=Kazuhiro kn-aut-name=畠和宏 kn-aut-sei=畠 kn-aut-mei=和宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部泌尿器科学教室 en-keyword=urinary tract infection kn-keyword=urinary tract infection en-keyword=G-CSF kn-keyword=G-CSF en-keyword=chemiluminescence kn-keyword=chemiluminescence en-keyword=neutrophil function kn-keyword=neutrophil function END start-ver=1.4 cd-journal=joma no-vol=109 cd-vols= no-issue=7-12 article-no= start-page=157 end-page=164 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19971225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A comparative study of obesity and life styles between Japanese and Chinese children kn-title=日本と中国における学童の肥満と生活習慣に関する比較研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In 1993 and 1994, a questionnaire survey was conducted on elementary school students of fourth and fifth grades living in Shengyang city (620 children), China and in Okayama city (579 children), Japan to determine defferences in the degree of obesity and life styles between the children of the two countries. Children whose body mass index (BMI) was 22 or higher were considered obese. The percentate of obese children was 5.7 in Shengyang and 5.4 in Okayama. Multiple logistic regression analysis of dietary patterns and life styles to explain childhood obesity in both countries showed the importance of consuming large amounts of grain products, potatoes, sugar, and oily foods as factors related to chilihood obesity. Physical activity has also been shown to be negatively and significantly associated with childhood obesity. Daily intake of enetgy, carbohydrate, and fat among obese children was significantly greater than those among nonobese children. The length of time spent watching television among the Japanese children was found to contribute to childhood obesity. en-copyright= kn-copyright= en-aut-name=WangZhuan en-aut-sei=Wang en-aut-mei=Zhuan kn-aut-name=王専 kn-aut-sei=王 kn-aut-mei=専 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学講座 en-keyword=児童肥満 kn-keyword=児童肥満 en-keyword=体格指数　（BMI） kn-keyword=体格指数　（BMI） en-keyword=生活習慣 kn-keyword=生活習慣 en-keyword=日中比較 kn-keyword=日中比較 END start-ver=1.4 cd-journal=joma no-vol=112 cd-vols= no-issue=3-8 article-no= start-page=89 end-page=93 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Case of Hyperestradiolemia induced by Tamoxifen kn-title=タモキシフェン投与により高エストラジオール血症を伴う両側性卵巣腫大をきたした1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A Case of hyperestradiolemia induced by Tamoxifen was reported. A 37-year old woman presented with right breast mass 3 days after delivery. The tumor, 1.2×1.0cm, was diagnosed to be cancer and quadrantectomy with axillar lymph node sampling was performed. Metastasis to the sampled lymph node (1/1) was observed. ER was negative but PgR was positive. Postoperative irradiation (50Gy) with adjuvant chemotherapy consisting of Epirubicin, CBDCA and 5FU was performed. After 2 months of Tamoxifen administration (20 mg/day), she developed vaginal bleeding and bilateral ovarian cysts with elevated serum level of estradiol (777 pg/ml). Tamoxifen for another month made the size of ovarian cysts larger and the concentration of estradiol higher (787 pg/mi). By discontinuing Tamoxifen, bilateral ovarian cysts disappeared and the level of estradiol recovered to normal in 3 months. The importance of careful observation of the hormonal environment of premenopausal breast cancer patient on Tamoxifen was discussed. en-copyright= kn-copyright= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=1 ORCID= en-aut-name=KojimaKazushi en-aut-sei=Kojima en-aut-mei=Kazushi kn-aut-name=小島一志 kn-aut-sei=小島 kn-aut-mei=一志 aut-affil-num=2 ORCID= en-aut-name=NoseSoichiro en-aut-sei=Nose en-aut-mei=Soichiro kn-aut-name=能勢聡一郎 kn-aut-sei=能勢 kn-aut-mei=聡一郎 aut-affil-num=3 ORCID= en-aut-name=HamayaKazuo en-aut-sei=Hamaya en-aut-mei=Kazuo kn-aut-name=浜家一雄 kn-aut-sei=浜家 kn-aut-mei=一雄 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山中央病院外科 affil-num=2 en-affil= kn-affil=岡山中央病院外科 affil-num=3 en-affil= kn-affil=岡山済生会総合病院 affil-num=4 en-affil= kn-affil=岡山済生会総合病院 en-keyword=閉経前乳癌 kn-keyword=閉経前乳癌 en-keyword=ホルモン療法 kn-keyword=ホルモン療法 en-keyword=エストラジオール kn-keyword=エストラジオール en-keyword=LH-RHアナログ kn-keyword=LH-RHアナログ END start-ver=1.4 cd-journal=joma no-vol=112 cd-vols= no-issue=9-12 article-no= start-page=205 end-page=209 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20001225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical pathway in breast conservation operation in Okayama Central Hospital kn-title=クリニカルパスウエイを用いた乳癌術後管理 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We performed a breast conservation operation in 5 patients using a clinical pathway in 1995 and analyzed the effect on the patient's outcome. Compared to 5 patients without a clinical parthway during the same time peried, the mean hospital stay decreased from 10.8 to 4.6 days and the amount of antibiotics decreased from 9.0 to 2.0g. A satisfactory effect was pbserved on the establishment of communication between staff and the standardized care of patiens. Breast conservation operation seems to be a good candidate for the introduction of a clinical pathway. Further improvement could be obtained by reviewing the outcome of patients. en-copyright= kn-copyright= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=1 ORCID= en-aut-name=KojimaKazushi en-aut-sei=Kojima en-aut-mei=Kazushi kn-aut-name=小島一志 kn-aut-sei=小島 kn-aut-mei=一志 aut-affil-num=2 ORCID= en-aut-name=OkaItsuho en-aut-sei=Oka en-aut-mei=Itsuho kn-aut-name=岡伊津穂 kn-aut-sei=岡 kn-aut-mei=伊津穂 aut-affil-num=3 ORCID= en-aut-name=KenmotsuMasakazu en-aut-sei=Kenmotsu en-aut-mei=Masakazu kn-aut-name=剣持雅一 kn-aut-sei=剣持 kn-aut-mei=雅一 aut-affil-num=4 ORCID= en-aut-name=KataikaMasafumi en-aut-sei=Kataika en-aut-mei=Masafumi kn-aut-name=片岡正文 kn-aut-sei=片岡 kn-aut-mei=正文 aut-affil-num=5 ORCID= en-aut-name=UmeokaTatsuo en-aut-sei=Umeoka en-aut-mei=Tatsuo kn-aut-name=梅岡達生 kn-aut-sei=梅岡 kn-aut-mei=達生 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山中央病院 affil-num=2 en-affil= kn-affil=岡山中央病院 affil-num=3 en-affil= kn-affil=岡山中央病院 affil-num=4 en-affil= kn-affil=岡山中央病院 affil-num=5 en-affil= kn-affil=岡山大学第一外科 affil-num=6 en-affil= kn-affil=岡山大学第一外科 en-keyword=クリニカルパス kn-keyword=クリニカルパス en-keyword=平均在院日数 kn-keyword=平均在院日数 en-keyword=医療費削減 kn-keyword=医療費削減 en-keyword=患者満足度 kn-keyword=患者満足度 END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue=3 article-no= start-page=203 end-page=210 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Morphological study of the limbus in dysplastic hips kn-title=臼蓋形成不全股における関節唇形態の研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In dysplastic hips, concentration of the weight and load on the lateral peripheral limbus causes its detachment and tearing, which is an important risk factor of coxarthrosis. Arthrograms of 77 hip joins in 40 patients (all female) with dysplastic hips were used to analyze the covering of the acetabulum and limbus. The average age at the time of arthrograms was 26 years (13-48). The limbus covering angle, a supplement to the CE angle, was added to the CE angle to measure the femoral head cover. Our results demonstrated a negative correlation between the degree of acetabular dysplasia and the length of the limbus. Insufficient bony acetabulums tended to be accompanied by proportionally longer limbi. Also, the limbus was significantly longer in cases with tears, suggesting that a long and unstable limbus might be more likely to undergo tearing, thereby increasing the risk of coxarthrosis. en-copyright= kn-copyright= en-aut-name=IshihamaTakuo en-aut-sei=Ishihama en-aut-mei=Takuo kn-aut-name=石濱琢央 kn-aut-sei=石濱 kn-aut-mei=琢央 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University Graduate School of Medicine and Dentistry Science of Functional Recovery and Reconstruction en-keyword=hip joint kn-keyword=hip joint en-keyword=acetabular dysplasia kn-keyword=acetabular dysplasia en-keyword=limbus kn-keyword=limbus en-keyword=arthrography kn-keyword=arthrography END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=2 article-no= start-page=97 end-page=101 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=動脈硬化発生に関わる血管内皮細胞のナノ／マイクロメカニクス解析―岡山大学医学賞 （砂田賞） を受賞して― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡則之 kn-aut-sei=片岡 kn-aut-mei=則之 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=橋本謙 kn-aut-sei=橋本 kn-aut-mei=謙 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=梶谷文彦 kn-aut-sei=梶谷 kn-aut-mei=文彦 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院歯学総合研究科　システム循環生理学 affil-num=2 en-affil= kn-affil=岡山大学大学院歯学総合研究科　システム循環生理学 affil-num=3 en-affil= kn-affil=岡山大学大学院歯学総合研究科　システム循環生理学 en-keyword=動脈硬化 kn-keyword=動脈硬化 en-keyword=血管内皮細胞 kn-keyword=血管内皮細胞 en-keyword=単球 kn-keyword=単球 en-keyword=ナノ／マイクロメカニクス kn-keyword=ナノ／マイクロメカニクス END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=2 article-no= start-page=143 end-page=147 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Macrophage scavenger receptor-A--deficient mice are resistant to diabetic nephropathy through amelioration of microinflammation kn-title=マクロファージスカベンジャー受容体（SR-A）は炎症を制御することにより糖尿病性腎症を抑制する en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaHitomi en-aut-sei=Kataoka en-aut-mei=Hitomi kn-aut-name=片岡仁美 kn-aut-sei=片岡 kn-aut-mei=仁美 aut-affil-num=1 ORCID= en-aut-name=ShikataKenichi en-aut-sei=Shikata en-aut-mei=Kenichi kn-aut-name=四方賢一 kn-aut-sei=四方 kn-aut-mei=賢一 aut-affil-num=2 ORCID= en-aut-name=SasakiMotofumi en-aut-sei=Sasaki en-aut-mei=Motofumi kn-aut-name=佐々木基史 kn-aut-sei=佐々木 kn-aut-mei=基史 aut-affil-num=3 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name=槇野博史 kn-aut-sei=槇野 kn-aut-mei=博史 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療教育統合開発センター; 岡山大学大学院医歯薬学総合研究科　腎･免疫･内分泌代謝内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎･免疫･内分泌代謝内科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎･免疫･内分泌代謝内科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎･免疫･内分泌代謝内科学 en-keyword=マクロファージスカベンジャー受容体 kn-keyword=マクロファージスカベンジャー受容体 en-keyword=SR-A kn-keyword=SR-A en-keyword=糖尿病性腎症 kn-keyword=糖尿病性腎症 en-keyword=炎症 kn-keyword=炎症 en-keyword=マクロファージ kn-keyword=マクロファージ END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=191 end-page=194 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Management of dyslipidemia in diabetic patients kn-title=糖尿病患者における脂質管理 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaHitomi en-aut-sei=Kataoka en-aut-mei=Hitomi kn-aut-name=片岡仁美 kn-aut-sei=片岡 kn-aut-mei=仁美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療教育統合開発センター END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=低線量放射線照射がマウスの酸化障害に及ぼす諸効果に関する研究 第１編:　Inhibitory Effects of Prior Low-dose X-irradiation on Ischemia-reperfusionInjury in Mouse Paw（低線量X線の事前照射がマウス足の虚血-再灌流障害に及ぼす抑制効果に関する検討）第２編:　Effects of Post Low-dose X-ray Irradiation on Carbon Tetrachloride-inducedAcatalasemic Mice Liver Damage（低線量X線の事後照射が四塩化炭素誘導によるアカタラセミアマウス肝の障害に及ぼす緩和効果に関する検討）　 kn-title=Study on Effects of Low-dose Irradiation on Oxidative Damage in Mice en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name=片岡隆浩 kn-aut-sei=片岡 kn-aut-mei=隆浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=YAGレーザを用いた高硬度・高機能材料への精密微細加工に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaNorio en-aut-sei=Kataoka en-aut-mei=Norio kn-aut-name=片岡範生 kn-aut-sei=片岡 kn-aut-mei=範生 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue=4 article-no= start-page=31 end-page=58 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200803 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Steps for Relaxation of Controls and Encouragement toward a China’s“Going Abroad”Strategy kn-title=中国“走出去”戦略推進に向けての管理・奨励政策 en-subtitle= kn-subtitle= en-abstract=筆者は先に，「中国“走出去”戦略のもつ意味」なる論稿において，国家戦略としての中国“走出去”戦略の含意について若干の考察を行った。“走出去”の英訳としては“going abroad”，“going global”が用いられているが，日本語としては対外経済進出活動とでもいえようか。しかし，それは国家戦略として打ち出されているから，単に中国企業の国際化，あるいは多国籍化という次元の企業戦略行動の範囲内でとらえるだけでは不充分で，今少し深層に踏み込んで検討してみる必要があると考え，その全体的枠組と重層的構造について整理を試みたのである。このようなことから，前稿ではその戦略の遂行のための整備と実態の進行状況については，立ち入って整理することができなかった。本稿では，中国のこの戦略遂行に向けての管理・奨励政策の諸側面について，いささかの整理作業を試みてみたい。現時点での関連する全般的概況を一瞥すると，２００５年末までの中国企業の非金融部門の対外直接投資累計投資残高は約５７２億ドル，対外請負工事，対外労務合作と対外設計コンサルタント業務を含めて一括対外経済合作と呼ばれるものの累計契約金額は２，２８６億ドル（完成営業額１，７２８億ドル），各々１，８５９億ドル（同上１，３５８億ドル），４０４億ドル（同上３５６億ドル），２３億ドル（同上１４億ドル），累計契約件数は４５万５，５１３件，このうち対外請負工事５万３，０７４件，対外労務合作３９万８，１１９件対外設計コンサルタント業務４，３２０件となっている。２００６年１２月１２日号の日本国際貿易促進協会発行の『国際貿易』紙の報ずるところによると，この時点で海外にある中国企業は１万社を超え，非金融業の資産総額は２，０００億ドル以上に達した。年間売上高は１，５００億ドル，所在国への納税額は３５億ドルに達するとされる。２００６年の『中国国際収支報告』によると，２００６年の中国の対外直接投資額は１８５億ドル，撤収・清算などの金額７億ドル，純流出額は１７８億ドルであったと報告されている。２００６年の非金融部門の対外直接投資額は１６１億ドル，累計額では７３３億ドルに達する。『国際商報』紙によると，２００６年末における中国の対外直接投資累計投資残高の世界の対外直接投資累計投資残高に占める比率は０．５５％，中国の対外請負工事実施累計金額の世界対外請負工事実施累計金額に占める比率は２．１％，中国の対外労務合作累計金額の世界の労務合作累計金額に占める比率は１．５％で，中国の対外経済進出は初級段階にあると総括している。 kn-abstract=Since 1997, China has earnestly taken the basic trends of economic globalization as the object to incorporate them into its world strategy, though China didn't exactly decide the “Reform and Opening up Policy” on the perspective of the economic globalization. China considered it more useful for her economic development and raising its position in the world political economy to set China into the main stream of economic globalization as the basic trend within the world economy. Economic globalization has twin aspects with a national economy ; inflow of foreign direct investment, portfolio investment, technology, labor and services, and outflow of them. This article focuses on the latter problems experienced by China. We can find some reasons in the background of China’s strategic orientation, as follows ; China must secure its economic security for smooth economic development , whereas, a few main developed countries strengthen controls over basic resources and market share of the world within global economic competition, China has developed conditions to use comparative advantages in some sectors to set up China’s direct investment enterprises abroad, thus increasing foreign currency reserves− an important factor , incurring frequent conflicts in exports, securing foreign technology by M&A. Currently, China’s foundation of political economy in “The Age of Peace and Development”, “The Age of Economic Globalization,” lays special emphasis on “The General Security Strategy” accountable not only to her own country’s military security but also to its economic security for said economic development. The main point is to strengthen global economic relations by economic cooperation−the latter aspects of economic globalization mentioned above. This article analyzes steps for the relaxation of controls over China’s enterprise activities overseas, the relaxation of foreign exchange controls, and the encouragement for China’s enterprises going abroad to study its rapid progress of said strategy . Lastly, it refers to Hong Kong’s vanguard position in a China’s “Going Abroad.” Strategy. en-copyright= kn-copyright= en-aut-name=KataokaSachio en-aut-sei=Kataoka en-aut-mei=Sachio kn-aut-name=片岡幸雄 kn-aut-sei=片岡 kn-aut-mei=幸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=広島経済大学 END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=65 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=19950131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Antibody to Propionibacterium acnes (P.acnes) in guinea pigs with pulmonary granulomatosis kn-title=Propionibacterium acnes感作肺肉芽腫モルモットの特異抗体の測定 en-subtitle= kn-subtitle= en-abstract=In guinia pig models of P.ances induced pulmonary granulomatosis, anti-P.acnes antibody activity in bronchoalveolar lavage fluid peaked at 1 week after the endotracheally injection and decreased progressively, attaining control animal value by 4 weeks. The change of lymphocyte counts paralleled the change of anti-P.acnes antibody activity levels in bronchoalveolar fluids. Furthermore, the degree of granuloma formation in the lung paralleled the rise of anti-P.acnes antibody activity level. This data suggests that the anti-P.acnes antibody play a central role in the induction of lymphocyte alveolitis in experimental pulmonary granulomatosis. kn-abstract=P.acnesを皮内前感作した後、P.acnes菌体壁成分をimcomplete Freund's adjuvantと共に気管内に投与して作製した実験的肺肉芽腫症モルモットにおける抗P.acnes抗体について検討した。気管支肺胞洗浄液中抗P.acnes抗体価は気管内投与後1週目ピークを示し2週目までは上昇が認められ、4週目では気管内投与前の値に復した。この経過は肺胞内リンパ球数の変動と軌を一にしており、抗体価とリンパ球数の間には正の強い相関が認められた。血清中の抗P.acnes抗体価は1週目に低下が認められ、2週以後に徐々に回復して4週以後は元に戻った。P.acnesの気管内投与により血清中の抗体は肺へと移行し、リンパ球浸潤による胞隔炎、更には類上皮細胞肉芽腫の形成にP.acnesの関与を示すものであった。 en-copyright= kn-copyright= en-aut-name=NakataYasunari en-aut-sei=Nakata en-aut-mei=Yasunari kn-aut-name=中田安成 kn-aut-sei=中田 kn-aut-mei=安成 aut-affil-num=1 ORCID= en-aut-name=MoriYoshihiro en-aut-sei=Mori en-aut-mei=Yoshihiro kn-aut-name=森由弘 kn-aut-sei=森 kn-aut-mei=由弘 aut-affil-num=2 ORCID= en-aut-name=EjiriTohgo en-aut-sei=Ejiri en-aut-mei=Tohgo kn-aut-name=江尻東伍 kn-aut-sei=江尻 kn-aut-mei=東伍 aut-affil-num=3 ORCID= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name=片岡幹男 kn-aut-sei=片岡 kn-aut-mei=幹男 aut-affil-num=4 ORCID= en-aut-name=HiramatsuJun-ichi en-aut-sei=Hiramatsu en-aut-mei=Jun-ichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 affil-num=2 en-affil= kn-affil=高松病院 affil-num=3 en-affil= kn-affil=市立吉備病院 affil-num=4 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=5 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=サルコイドーシス (sarcoidosis) kn-keyword=サルコイドーシス (sarcoidosis) en-keyword=プロピオニバクテリウム (propionibacteium acnes) kn-keyword=プロピオニバクテリウム (propionibacteium acnes) en-keyword=肺肉芽腫症 (pulmonary granulomatosis) kn-keyword=肺肉芽腫症 (pulmonary granulomatosis) en-keyword=動物実験モデル (experimental model) kn-keyword=動物実験モデル (experimental model) en-keyword=気管支肺胞洗浄液 (bronchoalveolar lavage) kn-keyword=気管支肺胞洗浄液 (bronchoalveolar lavage) END start-ver=1.4 cd-journal=joma no-vol=3 cd-vols= no-issue= article-no= start-page=19 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Sarcoidosis and Propionibacterium acnes kn-title=サルコイドーシス病態へのPropionibacterium acnesの関与 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although there have been numerous reports on the isolation of bacteria, fungus, and aetiological agents of chemical substances from specimens of patients with sarcoidosis, none of them have been substantiated. In any event, an understanding of the pathogenesis of pulmonary sarcoid is intimately linked to that of the processes involved in the accumulation of T-cells in the lower respiratory tract of individuals with sarcoidosis. Propionibacterium acnes was isolated at high rates and in high concetrations from lymph nodes in patients with sarcoidosis. However, the precise mechanism of granuloma formation and immunomodulation by P. acnes has not been elucidated yet. In patients with sarcoidosis, it was found that the high levels of interleukin-2 (IL-2) released from alveolar lymphocytes as well as interleukin-1, tumor necrosis factor (TNF) and interleukin-6 (IL-6) released from alveolar macrophages were stimulated by P. acnes. These cytokines (mainly IL-2), released by P. acnes in large quantities, play a major role in the compartmentalization of the T-cell population in the lung and lead to the formation of an alveolitis and granuloma in the lung parenchyma of patients with sarcoidosis. This paper focuses primarily on the role of the cytokine network in the pulmonary mononuclear cells in the lung of patients with sarcoidosis. en-copyright= kn-copyright= en-aut-name=NakataYasunari en-aut-sei=Nakata en-aut-mei=Yasunari kn-aut-name=中田安成 kn-aut-sei=中田 kn-aut-mei=安成 aut-affil-num=1 ORCID= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name=片岡幹男 kn-aut-sei=片岡 kn-aut-mei=幹男 aut-affil-num=2 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 affil-num=2 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=3 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=sarcoidosis kn-keyword=sarcoidosis en-keyword=macrophage kn-keyword=macrophage en-keyword=T-cell kn-keyword=T-cell en-keyword=interleukin-2 kn-keyword=interleukin-2 en-keyword=Propionibacterium acnes kn-keyword=Propionibacterium acnes END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=129 end-page=133 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of atopic asthma characterized by marked neutrophilia in BALF kn-title=気管支肺胞洗浄液（BALF）中に高度の好中球増多の見られたアトピー型喘息の一例 en-subtitle= kn-subtitle= en-abstract=The clinical course and characteristics of a case with atopic asthma, showing marked neutrophilia in BALF and severe asthma attacks, were observed the frequency of neutrophils in BALF decreased followed by the improvement of her asthma attacks with therapy. The frequency of neutrophils in BALF was 65.4% at the initial stage before the therapy and decreased to 5.6% at attackfree stage after the therapy. The changes in frequency of neutrophils in BALF, obserbed in this case, should be noticed, because the cell in BALF were hardly affected by any treatment. kn-abstract=気管支肺胞洗浄液（BALF）中に高度の好中球の増多が見られ，治療により臨床症状の軽快と共にBALF中の好中球の減少を認めたアトピー型喘息の一例を経験した。経過中5回施行したBALF中の好中球百分率はそれぞれ65.4％，56.2％，42.4％，5.6％，5.6％であり，4回目，5回目では著明な好中球減少を認めた。本症例の如き症例は今後増加することが予想され，その発症病態を含め今後さらに症例を重ねて検討して行く必要があると 考えられた。 en-copyright= kn-copyright= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshirou en-aut-sei=Tanizaki en-aut-mei=Yoshirou kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= en-aut-name=KataokaHisakazu en-aut-sei=Kataoka en-aut-mei=Hisakazu kn-aut-name=片岡久和 kn-aut-sei=片岡 kn-aut-mei=久和 aut-affil-num=6 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=7 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=アトピー型喘息 (Atopic asthma) kn-keyword=アトピー型喘息 (Atopic asthma) en-keyword=好中球 (Neutrophil) kn-keyword=好中球 (Neutrophil) en-keyword=気管支肺胞洗浄法 (Bronchoaiveolar lavage) kn-keyword=気管支肺胞洗浄法 (Bronchoaiveolar lavage) END start-ver=1.4 cd-journal=joma no-vol=85 cd-vols= no-issue=1 article-no= start-page=45 end-page=50 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Lactobacillus casei 34143のニトロソグアニジン処理変異株による大豆乳での乳酸およびジアセチル生成 kn-title=Lactic Acid and Diacetyl Production of Nitrosoguanidine Mutants Derived from Lactobacillus casei 34143 in Soymilk en-subtitle= kn-subtitle= en-abstract=大豆乳の発酵に有効な乳酸菌株を検索する目的で、ラクトース非発酵性Lactobacillus casei 34143のニトロソグアニジン(NTG)処理変異株について、液体培地での生育性ならびに大豆乳培地での乳酸とジアセチル生成能を温度勾配培養法によって検討した。また、NTG処理変異株におけるクエン酸およびラクトースの取り込みと分解に関与する酵素の活性についても調べた。その結果、親株ならびに変異株の液体培地での生育至適温度はほぼ同じ値を示し、いずれも34.5℃から35.9℃の範囲であった。しかしながら、大豆乳培地での乳酸とジアセチル生生成能には違いを示す菌株があった。とくにジアセル生成の至適温度は親株が32.7℃であるのに対して、変異株(N-14株,N-15株およびN-25株)では29.6℃であり、そして変異株のL-7株では26.4℃であった。一方、供試した親株と変異株のはすべてクエン酸透過酵素ならびにクエン酸分解酵素活性を示さなかったが、ラクトース代謝能を獲得した変異株(N-25株とS-3-1株)はβ-ガラクトシダーゼとフォスフォ-β-ガラクトシダーゼの活性を示した。 kn-abstract=Production of acid and diacetyl by nitrosoguanidine mutants of Lactobacillus casei 34143 was evaluated in soymilk. Optimum temperature for growthof the five cultures varied between 34.5 and 35.9℃. However, the temperature required for maximum production of diacetyl in soymilk in the parent culture was 32.7℃ and mutants such as N-14, N-15 and N-25 required a temperature of 29.6℃, while another mutant, L-7 required 26.4℃ for production of diacetyl. Parent and mutant cultures were deficient in citrate permease and citritase synthetic mechanisms, although lactose-utilising mutants (N-25 and S-3-1) possessed both β-galactosidase and phospho-β-galactosidase. en-copyright= kn-copyright= en-aut-name=MiyamotoTaku en-aut-sei=Miyamoto en-aut-mei=Taku kn-aut-name=宮本拓 kn-aut-sei=宮本 kn-aut-mei=拓 aut-affil-num=1 ORCID= en-aut-name=ReddyNarra Srinivas en-aut-sei=Reddy en-aut-mei=Narra Srinivas kn-aut-name=レディナラ スリニバス kn-aut-sei=レディ kn-aut-mei=ナラ スリニバス aut-affil-num=2 ORCID= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 en-keyword=Lactobacillus casei kn-keyword=Lactobacillus casei en-keyword=nitrosoguanidine mutants kn-keyword=nitrosoguanidine mutants en-keyword=soymilk kn-keyword=soymilk en-keyword=lactic acid kn-keyword=lactic acid en-keyword=diacetyl kn-keyword=diacetyl END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=1 article-no= start-page=163 end-page=167 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Isolation and Antibacterial Properties of Lactic Acid Bacteria Exhibiting Antagonistic Effects against Food Spoilage Bacteria kn-title=食品汚染細菌に対して抗菌活性を示す乳酸菌の分離とその抗菌特性 en-subtitle= kn-subtitle= en-abstract=発酵食品を製造するためにスターターカルチャーを用いことは、既に古くから行われており、中でも乳酸菌は、発酵乳、チーズ、酒類、味噌、醤油、肉製品などの製造に重要な役割をはたしている。その役割は乳酸発酵、タンパク質分解、脂肪分解などによって発酵食品に風味を与えるとともに、発酵食品の保存性の向上にも関与している。特に、食品中に発生する病原菌や腐敗菌に対して、スターターカルチャーが顕著な拮抗作用を示すことが最近の研究によって明らかにされ、スターターカルチャーの抗菌性について関心が高まっている。乳酸菌が生産する抗菌性物質には、乳酸をはじめとする有機酸、揮発性脂肪酸、過酸化水素、安息香酸などが知られている。また、乳酸菌はバクテリオシンと呼ばれるタンパク質性の抗菌性物質を生産することも報告されている。乳酸菌の生産するバクテリオシンについては、ディプロコクシン、ナイシン、ヘルベティシンなどの多数の抗菌性ペプチドが単離されている。しかし、これらのバクテリオシンのほとんどが、類縁菌ないしはある種のグラム陽性菌に対して作用するものはまれである。本研究では、発酵食品の製造に有効な抗菌性物質を生産する乳酸菌スターターの検索および抗菌性物質を直接利用した食品の開発に資する目的で、食品汚染細菌に対して抗菌活性を示す乳酸菌を探索した。そして、強い抗菌活性を示す菌株については、その菌株の生産する抗菌性物質の性質を調べた。 kn-abstract=The 124 strains of lactic acid bacteria in this study were screened for antibacterial activities against food spoilage bacteria. All lactic strains were fermented for 3-5 days in 10% reconstituted skim milk supplemented with 0.5% yeast extract and 0.5% glucose. Culture filtrates from skim milk media adjusted to pH 4.5, centrifuged at 15,000-rpm and filter-sterilized for antagonistic activities by paper disc assays, using Escherichia coli, Pseudomonas fragi, Staphylococcus aureus and Bacillus subtilis as test organisms. One out of 124 lactic strains showed greater inhibitory activities against the 4 test organisms. The strain from lnner Mongolian cheese, designated as IMC-1, belonged to the Lactobacillus acidophilus group and was selected for further studies. This strain showed considerable inhibitory effects against other lactic strains such as Lactobacillus helveticus and Streptococcus thermophilus under conditions that reduced the effects of organic acids. The antibacterial activities against Pseudomonas fragi IFO 3458 were lost at more than ph 5.2 and remaining inhibition rate after treatments at 121℃ for 20 min was approximately 63.5%. The antibacterial substance was extracted from skim milk culture filtrates with ethanol and was passed through Sephadex G-25 columns. It was presumed to be a bacteriocin-like substance with a moleculr weight of 1,000～3,500. en-copyright= kn-copyright= en-aut-name=MiyamotoTaku en-aut-sei=Miyamoto en-aut-mei=Taku kn-aut-name=宮本拓 kn-aut-sei=宮本 kn-aut-mei=拓 aut-affil-num=1 ORCID= en-aut-name=MorinakaOsamu en-aut-sei=Morinaka en-aut-mei=Osamu kn-aut-name=守中修 kn-aut-sei=守中 kn-aut-mei=修 aut-affil-num=2 ORCID= en-aut-name=MatsumotoHiroshi en-aut-sei=Matsumoto en-aut-mei=Hiroshi kn-aut-name=松本博志 kn-aut-sei=松本 kn-aut-mei=博志 aut-affil-num=3 ORCID= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=4 ORCID= en-aut-name=MokSoo Jong en-aut-sei=Mok en-aut-mei=Soo Jong kn-aut-name=睦宗洙 kn-aut-sei=睦 kn-aut-mei=宗洙 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=岡山大学 en-keyword=lactic acid bacteria kn-keyword=lactic acid bacteria en-keyword=antibacterial activity kn-keyword=antibacterial activity en-keyword=food spoilage bacteria kn-keyword=food spoilage bacteria en-keyword=Lactobacillus acidophilus group kn-keyword=Lactobacillus acidophilus group en-keyword=antimicrobials kn-keyword=antimicrobials END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=1 article-no= start-page=79 end-page=85 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Softening and Salts Movement in the Ripening Process of Camembert Cheese kn-title=カマンベールチーズの熟成中における軟化と塩類の動態 en-subtitle= kn-subtitle= en-abstract=本研究は、カマンベールチーズの熟成における軟化の主因と考えられているチーズ内でのpHや塩類の動態を追跡したものである。熟成開始前のグリーンチーズに比べて熟成が完了した4週目のチーズ中心部では、pHは4.5から7.8に上昇、乳酸は1.0% から0.1% で約1/10に低下、アンモニアは100g当たり0.04gから0.063gで約1.5倍に上昇、カルシウムは100g当たり0.3gから0.04gで約1/10のに減少、リンは100g当たり0.25gから0.12gで約1/2に減少した。これらの変化が本チーズの熟成軟化の要件と推察される。培養試験から、本チーズに使用したかびスターター　Pen. candidumに乳酸の代謝能とアンモニアの生成能を有すること、その結果pHが上昇することが確認された。しかし、未成熟のグリーンチーズをアンモニア蒸気にさらした場合も、乳酸を含まないチーズを熟成させた場合も正常な軟化は生じなかった。最も顕著な変化は、pH、乳酸、カルシウムに認められたが、これらのチーズ内での動態が主導的な役割を果たすものと推察された。 kn-abstract=Experimental Camembert cheese softened from the surface to the center portion after 3-4 weeks of ripening.As ripening progressed,pH value rose from 4.5 to 7.8,lactic acid content decreased from 1.0% to 0.1%,ammonia content increased from 0.04g to 0.063g/100g,calcium content decreased from 0.3g to 0.048g/100g and phosphorus content decreased from 0.25g to 0.12g/100g in the center portion of cheese. The changes in these values were considered as criteria leading to softening of mold surface-ripened cheeses.Mold starter Penicillium candidum AM used the cheese manufacture possesses the abilities lactic acid,producing ammonia and lowering pH when supplemented with lactic acid and peptone Czapek Dox solution.However,normal softening was not observed by incubation of green cheese under ammonia atomsphere conditions.Also,lactic acid free cheese did not soften in spite of mold growth.It is proposed that the primary factor of softening in mold surface-ripened cheese is a rise of casein solubility caused by lowering of calcium crosslinking due to a decrease of calcium level in the cheese texture.The results suggested that the lactic acid metabolism and pH rise play a main part in inducement,and that insolble calcium phosphate accumulates in the cheese surface. en-copyright= kn-copyright= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=1 ORCID= en-aut-name=NukadaKazutaka en-aut-sei=Nukada en-aut-mei=Kazutaka kn-aut-name=額田和啓 kn-aut-sei=額田 kn-aut-mei=和啓 aut-affil-num=2 ORCID= en-aut-name=KimuraTamao en-aut-sei=Kimura en-aut-mei=Tamao kn-aut-name=木村玉青 kn-aut-sei=木村 kn-aut-mei=玉青 aut-affil-num=3 ORCID= en-aut-name=YoneyaTakefumi en-aut-sei=Yoneya en-aut-mei=Takefumi kn-aut-name=米屋武文 kn-aut-sei=米屋 kn-aut-mei=武文 aut-affil-num=4 ORCID= en-aut-name=MiyamotoTaku en-aut-sei=Miyamoto en-aut-mei=Taku kn-aut-name=宮本拓 kn-aut-sei=宮本 kn-aut-mei=拓 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山県真庭地方振興局 affil-num=3 en-affil= kn-affil=ケンコーマヨネーズ株式会社 affil-num=4 en-affil= kn-affil=静岡県立大学短期大学部 affil-num=5 en-affil= kn-affil=岡山大学 en-keyword=Camembert cheese kn-keyword=Camembert cheese en-keyword=Cheese ripening kn-keyword=Cheese ripening en-keyword=cheese softening kn-keyword=cheese softening en-keyword=Salt distribution kn-keyword=Salt distribution END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=1 article-no= start-page=39 end-page=44 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=200002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Caracteristics of Bacteriocin Produced by Enterococcus Strain from Meat kn-title=食肉より分離した乳酸球菌が生産するバクテリオシンの抗菌特性 en-subtitle= kn-subtitle= en-abstract=発酵肉製品中の汚染細菌の増殖抑制を目的として、市販の食肉より乳酸菌732株を単離し、バクテリオシン産生能を有する乳酸菌の検索を行った。スクリーニングはペーパーディスク法で行い、被検菌には Staphylococcus aureus IAM1011 と Listeria monocytogenes VTU206 を用いた。スクリーニングによりバクテリオシン様物質生産能を示す菌株は4株で、最も抗菌活性を示す1株についての同定を行った結果、本菌株は Enterococcus faesium C210 と同定した。抗菌活性は対数増殖期の後半から定常期の前半にかけて最大となり、それ以降は低下する傾向を示した。また、Catalaseによる処理では失活しなかったが、Pepsin, Carboxypeptidase, Aminopeptidase, Pronase E およびProteinase K等の蛋白質分解酵素による処理で失活した。熱処理の影響を調べたところ、121℃で15分の条件においても抗菌活性は低下しなかった。pHに対しては、pHが高くなるにつれて抗菌活性が低下した。次に抗菌スペクトルを検討した結果、乳酸菌5株の他に、Staphylocossus aureus IAM1011 と Listeria monocytogenes VTU206 等の食品汚染細菌に対して抗菌活性を示したが、グラム陰性菌に対しては示さなかった。また、食品汚染細菌に対する抗菌作用を調べたところ、pH4.5では静菌作用を示し、pH6.5では殺菌作用を示した。 kn-abstract=To control the growth of foodborne spoilage bacteria in fermentes meat produncts, 732 strains of lactic acid bacteria were isolated from commercial meats, and their inhibitory activities were investigated by paper disc assay using Staphylococcus aureus IAM 1011 and Listeria monocytogenes VTU 206 as indicator starins. Four starins produced antibacterial substances and one of them showed greater activity against two indicator strains. It was identified as Enterococcus faecium, and it was designed as strain C210. Antibacterial activity was high between the late-logarithmic growth phase and early-stationary growth phase in broth media. Activity in the antibacterial substance was not detectable after treatments with proteolysis enzymes such as pepsin, carboxypeptidase, aminopeptidase, pronase E and proteinase K. The bacteiocin was heat-stable and showed greater antibacterial activity at low pH. The substance showed antibacterial activity against 5 species of lactic acid bacteria in addition to Staphylococcus aureus and Listeria monocytogenes, although it was not active against Gram-negative bacteria. It exhibited bacteriostatic action at pH 4.5, and bactericidal action at pH 6.5 against Listeira monocytogenes as an indicator strain. en-copyright= kn-copyright= en-aut-name=OkabeShigeto en-aut-sei=Okabe en-aut-mei=Shigeto kn-aut-name=岡部重人 kn-aut-sei=岡部 kn-aut-mei=重人 aut-affil-num=1 ORCID= en-aut-name=MokJong-Soo en-aut-sei=Mok en-aut-mei=Jong-Soo kn-aut-name=睦宗洙 kn-aut-sei=睦 kn-aut-mei=宗洙 aut-affil-num=2 ORCID= en-aut-name=SewakiTomomitsu en-aut-sei=Sewaki en-aut-mei=Tomomitsu kn-aut-name=瀬脇智満 kn-aut-sei=瀬脇 kn-aut-mei=智満 aut-affil-num=3 ORCID= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=4 ORCID= en-aut-name=IzumimotoMasatoshi en-aut-sei=Izumimoto en-aut-mei=Masatoshi kn-aut-name=泉本勝利 kn-aut-sei=泉本 kn-aut-mei=勝利 aut-affil-num=5 ORCID= en-aut-name=MiyamotoTaku en-aut-sei=Miyamoto en-aut-mei=Taku kn-aut-name=宮本拓 kn-aut-sei=宮本 kn-aut-mei=拓 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=日本食研株式会社 affil-num=2 en-affil= kn-affil=国立水産振興院 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=岡山大学 affil-num=6 en-affil= kn-affil=岡山大学 en-keyword=Enterococuus faecium kn-keyword=Enterococuus faecium en-keyword=meat kn-keyword=meat en-keyword=bacteriocin kn-keyword=bacteriocin en-keyword=Staphylococcus aureus kn-keyword=Staphylococcus aureus en-keyword=Listeria monocytogenes kn-keyword=Listeria monocytogenes END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=日本人骨形成不全症におけるⅠ型コラーゲンの遺伝子解析 kn-title=Mutations in field name="type" I Collagen genes in Japanese OI (osteogenesis imperfecta) patients en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaKyoko en-aut-sei=Kataoka en-aut-mei=Kyoko kn-aut-name=片岡京子 kn-aut-sei=片岡 kn-aut-mei=京子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=難溶解性薬物の経口吸収性評価のための新しいin vitroシステムの構築とその有用性に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaMakoto en-aut-sei=Kataoka en-aut-mei=Makoto kn-aut-name=片岡誠 kn-aut-sei=片岡 kn-aut-mei=誠 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=新規免疫調節薬FTY720の同種移植および実験的自己免疫性脳脊髄炎に対する薬理作用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaHirotoshi en-aut-sei=Kataoka en-aut-mei=Hirotoshi kn-aut-name=片岡裕敏 kn-aut-sei=片岡 kn-aut-mei=裕敏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=19910328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=大気境界層における気象観測への音波探査装置の適用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡毅 kn-aut-sei=片岡 kn-aut-mei=毅 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=19910930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=脾臓および末梢血単核細胞より誘導したヒト Lymphokine-activated killer (LAK) 細胞におけるパーフｫリンの発現に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡和彦 kn-aut-sei=片岡 kn-aut-mei=和彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=19810630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ブレオマイシンによるクロマチンDNA鎖切断の定量的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡和博 kn-aut-sei=片岡 kn-aut-mei=和博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ヒト口蓋扁桃高内皮細静脈基底膜におけるコンドロイチン硫酸プロテオグリカン:鉄コロイド染色による光顕ならびに電顕的解析 kn-title=Chondroitin Sulfate Proteoglycan at the Basal Lamina Beneath High Endothelial Cells in Human Palatine Tonsils: A Light and Electron Microscopic Study Using the Cationic Colloidal Iron Method en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡祐子 kn-aut-sei=片岡 kn-aut-mei=祐子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=19800331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=粒乳汁のTriglyceride構造と乳児の脂肪利用に関する研究(中性脂肪β位パルミチン酸含量の異なる高脂肪組成乳汁で哺育された低出生体重児の脂質代謝) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡直樹 kn-aut-sei=片岡 kn-aut-mei=直樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=19950930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=胃癌､大腸癌における DCC mRNA 発現減弱例の検討 kn-title=Decreased Expression of DCC mRNA in Gastric and Colorectal Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡正文 kn-aut-sei=片岡 kn-aut-mei=正文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ダール食塩感受性高血圧ラットの高血圧進展における食塩制限下での一酸化窒素およびレニンーアンギオテンシン系の役割に関する検討 kn-title=The role of NO and renin-angiotensin system in development of hypertension in salt-restricted Dahl rats en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡秀雄 kn-aut-sei=片岡 kn-aut-mei=秀雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=19811231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Human Placental Lactogen (HPL) による妊婦血の鑑別 kn-title=Human Placental Lactogen in Blood and Blood Stains for the Identification of Pregnancy. en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡敬一 kn-aut-sei=片岡 kn-aut-mei=敬一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ヒト末梢血単球の走性に関する研究 第1編 単球走性測定法の検討 第2編 肺癌患者の単球走性 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡幹男 kn-aut-sei=片岡 kn-aut-mei=幹男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=83 cd-vols= no-issue=1 article-no= start-page=9 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=発酵肉における香辛料の抗菌効果 kn-title=Antibacterial Eftects of Spices on Fermented Meat en-subtitle= kn-subtitle= en-abstract= kn-abstract=Garlic and coriander were examined to determine their antibacterial and promotional activity against various bacteria. By paper disc diffusion, was admitted some inhibition of spoilage and pathogenic bacteria. Garlic revealed its antibacterial activity against in order of Staphylococcus aureus. Bacillus subtilis. Escherichia coli and Pseudomonas fragi. While coriander demonstrated an antibacterial activity against Bacillus subtilis. Sta-phylococcus aureus. Escherichia coli and Pseudomonas fragi in orderly. Neither spice showed any inhibitory effect against Lactobacillus plantarum and ediococcus pentosaceus. In liquid medium, they promoted the growth of both Lactic acid bacteria cultures, but there was inhibition of the growth of some spoilage and pathogenic bacteria. In beef patties, the addition of both spices resulted in the inhibition of some spoilage bacteria, however, there was activation of the growth of Lactic acid bacteria. The results indicate that the use of garlic and coriander in fermented meat could encourage an optimal fermentation process and depress the presence of spoilage and pathogenic bacteria. en-copyright= kn-copyright= en-aut-name=DarmadjiPurnama en-aut-sei=Darmadji en-aut-mei=Purnama kn-aut-name=ダルマジプルナマ kn-aut-sei=ダルマジ kn-aut-mei=プルナマ aut-affil-num=1 ORCID= en-aut-name=IzumimotoMasatoshi en-aut-sei=Izumimoto en-aut-mei=Masatoshi kn-aut-name=泉本勝利 kn-aut-sei=泉本 kn-aut-mei=勝利 aut-affil-num=2 ORCID= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 en-keyword=Antibacterial Eftects of Spices kn-keyword=Antibacterial Eftects of Spices en-keyword=Fermented Meat kn-keyword=Fermented Meat END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=1 article-no= start-page=139 end-page=146 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Altered Metabolism in Lactose-negative Mutants of Lactobacillus casei by Conjugation kn-title=細胞接合によるラクトース非発酵性Lactobacillus caseiの代謝機能改造の試み en-subtitle= kn-subtitle= en-abstract= kn-abstract=ラクトース非発酵性Lactobacillus caseiはラクトース発酵能を欠くために,牛乳培地では酸生成がみられず,乳業用乳酸菌として応用する場合,ラタトース発酵性をこの菌株に付与する必要がある.そこで,Lactobacillus casei subsp. caseiのラクトース非発酵性(Lac-株である.34143S(ストレプトマイシン耐性,Strr)および34143P(ペニシリン耐性,Penr)株を分離し,それらを受容菌として液体培地中や寒天培地上での接合法によって,Lac+交配菌の作出を検討した.その結果,受容菌と供与菌Lactobacillus delbrueckii subsp. bulgaricus7235との交配で得られたLac+StrrやLac+Penrの交配菌,Lactobacillus rhamnosus IFO3245とのLac+StrrやLac+Penr株およびStreptococcus salivarius subsp. Thermophilus 18235とのLac+Penr株を3回の繰り返し試験で再現性高く得ることができた.それらの接合頻度は,供与菌当たり,1.1×10-5から1.6×10-2の範囲であり,比較的高い頻度でLac+交配菌の得られる組合せもあった. 得られた交配菌はほとんどが脱脂乳を凝固し,ラクトース発酵性は安定であった.また交配菌の糖類発酵性やその他の性状試験から,受容菌と供与菌にない性質を発現した交配菌や受容菌のもつ性質の一部を欠落した交配菌もあった.しかし形態はいずれも受容菌と同一であった.これらのラクトース発酵性交配菌の出現は,自然突然変異,形質導入および形質転換によるものではなく,受容菌と供与菌の細胞接合によりラクトース発酵性が発現したものと考えられた.またこのラクトース発酵性の発現は,プラスミドの伝達によるものではないと思われた.しかし詳細については今後さらに検討する必要がある。 en-copyright= kn-copyright= en-aut-name=MiyamotoTaku en-aut-sei=Miyamoto en-aut-mei=Taku kn-aut-name=宮本拓 kn-aut-sei=宮本 kn-aut-mei=拓 aut-affil-num=1 ORCID= en-aut-name=MoritaHidetoshi en-aut-sei=Morita en-aut-mei=Hidetoshi kn-aut-name=森田英利 kn-aut-sei=森田 kn-aut-mei=英利 aut-affil-num=2 ORCID= en-aut-name=NishiokaKohshi en-aut-sei=Nishioka en-aut-mei=Kohshi kn-aut-name=西岡功志 kn-aut-sei=西岡 kn-aut-mei=功志 aut-affil-num=3 ORCID= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=1 end-page=4 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=19940330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=渋ガキ果実における樹上脱渋の時期について en-subtitle= kn-subtitle= en-abstract= kn-abstract=渋ガキの'平核無'と'愛宕'を供試し,樹上でのエタノールの処理時期と脱渋の程度やヘタの障害発生などとの関係を調査した。'平核無'の場合,9月中の処理では着色が優れ,脱渋も完全であったが,一方落果率が高く,ヘタに障害が発生し,また果肉に多数の褐斑が生じた。10月中旬の処理では落果やヘタの障害には問題がなかったが,脱渋の不完全な果実があった。果実重には処理時期による差はなかった。これらのことから,'平核無'果実の樹上での脱渋時期としては10月上旬が適当と思われた。なお,'愛宕'果実では,いずれの時期とも樹上での脱渋は全く不可能であった。 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=久保田尚浩 kn-aut-sei=久保田 kn-aut-mei=尚浩 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=1 article-no= start-page=15 end-page=23 dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=1980 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Acid-Catalyzed Hydrolysis of Sucrose and Protein in Sweetened Fermented Milk Beverage kn-title=加糖酸乳飲料におけるショ糖とタンパク質の酸分解について en-subtitle= kn-subtitle= en-abstract= kn-abstract=加糖酸乳飲料の長期間保存中におこる褐色化や味覚の変化は,ショ糖の酸分解による転化糖に起因するものと考え,加糖酸乳飲料に類似した各種の条件下でショ糖の酸分解を経時的に観察し,併せてタンパク質の酸分解についても検討を加えた. その結果,次のような結論を得た. 1)モデル系によるショ糖とカゼインの酸分解は,温度の高いほど,また加熱時間や保存時間が長いほど速く進行するる. 温度が一定のときには酸度が高いものほど酸分解が起こりやすい. ショ糖濃度は高いものほど,またカゼイン濃度は低いものほど酸分解が起こりやすい. 2)実際の製品の場合,乳タンパク質の有する緩衝作用のためにモデル系と同じ条件でもそのpHがモデル系よりもやや高く,それだけ酸分解が起こりにくい. 3)製品の品質維持,すなわち褐色化や味覚の変化を防止するためには製造段階において転化糖の含量が多い不純なショ糖を使用したり,グルコースを併用したりせず,良質のショ糖を使用するのが望ましい. また殺菌時間を最小にして殺菌後すみやかに冷却し,保存時は冷蔵することが必要と思われる。 en-copyright= kn-copyright= en-aut-name=MiyamotoTaku en-aut-sei=Miyamoto en-aut-mei=Taku kn-aut-name=宮本拓 kn-aut-sei=宮本 kn-aut-mei=拓 aut-affil-num=1 ORCID= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=2 ORCID= en-aut-name=NakaeToshitaka en-aut-sei=Nakae en-aut-mei=Toshitaka kn-aut-name=中江利孝 kn-aut-sei=中江 kn-aut-mei=利孝 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue= article-no= start-page=12 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ピオーネの品質改善に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue= article-no= start-page=8 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=巨峰の着色改善に関する研究(第1報) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue= article-no= start-page=17 end-page=19 dt-received= dt-revised= dt-accepted= dt-pub-year=1985 dt-pub=19850627 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=西南暖地におけるリンゴ栽培に関する研究 (第5報)4年生樹における側枝形成の促進 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue= article-no= start-page=13 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=1985 dt-pub=19850627 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=西南暖地におけるリンゴ栽培に関する研究 (第4報)有袋栽培と無袋栽培の比較 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=1 article-no= start-page=61 end-page=67 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=1978 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Quality of Raw Milk Produced in Okayama Prefecture : Bacterial Count kn-title=岡山県の原料乳の乳質について 細菌数検査の部 en-subtitle= kn-subtitle= en-abstract= kn-abstract=前報の岡山県で生産された原料乳の成分的乳質の調査に引きつづき,今回はその細菌学的乳質を調査した. その結果次のような結論を得た. 1)原料乳の細菌学的乳質は,夏季の乳温の上昇とともに低下した. また乳温は細菌数のみならず細菌叢にも影響するものと思われる. 2)細菌数の地域的な差違はほとんど認められなかった. 3)総菌数,生菌数,低温細菌数および耐熱性細菌数の平均値はそれぞれ4.7×106/ml,1.1×106/ml,5.6×104/mlおよび2.7×104/mlであった. 4)63℃,30分,85℃,20分および100℃,10分の加熱処理乳より耐熱性細菌を分離し,その分離菌株の耐熱性を再試験した. それらの分離菌株の中には63℃,30分あるいは85℃,20分の加熱処理に生存するものがあった。 en-copyright= kn-copyright= en-aut-name=NakaeToshitaka en-aut-sei=Nakae en-aut-mei=Toshitaka kn-aut-name=中江利孝 kn-aut-sei=中江 kn-aut-mei=利孝 aut-affil-num=1 ORCID= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=2 ORCID= en-aut-name=MiyamotoTaku en-aut-sei=Miyamoto en-aut-mei=Taku kn-aut-name=宮本拓 kn-aut-sei=宮本 kn-aut-mei=拓 aut-affil-num=3 ORCID= en-aut-name=SegawaKatsushi en-aut-sei=Segawa en-aut-mei=Katsushi kn-aut-name=瀬川且志 kn-aut-sei=瀬川 kn-aut-mei=且志 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue= article-no= start-page=24 end-page=26 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840702 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=西南暖地におけるリンゴ栽培に関する研究 第3報 初成り果実の袋掛けと品質 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue= article-no= start-page=21 end-page=23 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840702 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ブドウ, '巨峰'の着色と収量の関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue= article-no= start-page=19 end-page=20 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840702 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ブドウ,'キャンベル･アーリー'における品質向上と栽培の省力化に関する研究 第8報 トンネル被覆の果実品質に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue= article-no= start-page=11 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840702 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ブドウ,'キャンベル･アーリー'における品質向上と栽培の省力化に関する研究 第7報 台木品種の違いと生育及び収量 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=51 cd-vols= no-issue=1 article-no= start-page=57 end-page=62 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=1978 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Quality of Raw Milk Produced in Okayama Prefecture : Chemical Composition kn-title=岡山県の原料乳の乳質について 化学的組成の部 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1976年4月より1977年2月までの各月に,岡山県内10地区の原料乳,合計110個の試料を採取し,その化学的組成を調査した. その結果次のような結論を得た. 1)季節的にみると,脂肪は春と夏季が低く,秋と冬季が高い. 乳糖は一般に秋季に低い値であった. 蛋白質および無脂乳固形分は8月に最低値を示す. また無脂乳固形分においては8%未満のものが季節により若干みられた. 2)地域的にみると,特定地区の乳質が他地区に比較して全般的に劣るものがみられた. 3)成分的にみると,PHは6.70～6.90,酸度は0.13～0.15%,比重は1.0301～1.0338,脂肪は3.25～3.70%,蛋白質は2.95～3.35%,乳糖は4.20～4.45%,灰分は0.68～0.73%そして無脂乳固形分は8.15～8.75%の範固にあるものが多い. なおpH,酸度,比重,蛋白質,乳糖,灰分および無脂乳固形分の平均値はそれぞれ6.80,0.14%,1.0313,3.39%,3.13%,4.28%,0.68%および8.29%であった. 4)全般的にみると,全国平均と比較して脂肪はほぼ等しく,無脂乳固形分は若干高く,岡山県の原料乳の乳質は全国的にみて標準ないしはそれ以上のものと思われる。 en-copyright= kn-copyright= en-aut-name=NakaeToshitaka en-aut-sei=Nakae en-aut-mei=Toshitaka kn-aut-name=中江利孝 kn-aut-sei=中江 kn-aut-mei=利孝 aut-affil-num=1 ORCID= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=2 ORCID= en-aut-name=MiyamotoTaku en-aut-sei=Miyamoto en-aut-mei=Taku kn-aut-name=宮本拓 kn-aut-sei=宮本 kn-aut-mei=拓 aut-affil-num=3 ORCID= en-aut-name=KondoAkitaka en-aut-sei=Kondo en-aut-mei=Akitaka kn-aut-name=近藤彰孝 kn-aut-sei=近藤 kn-aut-mei=彰孝 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=17 end-page=21 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19830312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=西南暖地におけるリンゴ栽培に関する研究 第2報 2年生樹における側枝発生の促進 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=13 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19830312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ブドウ,'キャンベル･アーリー'における品質向上と栽培の省力化に関する研究 第6報 平棚･短梢剪定樹における整枝･剪定方法の改良 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=9 end-page=12 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19830312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ブドウ,'キャンベル･アーリー'における品質向上と栽培の省力化に関する研究 第5報 トンネル被覆の取除き時期が果実の成熟に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=4 cd-vols= no-issue= article-no= start-page=36 end-page=42 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=西南暖地におけるリンゴ栽培に関する研究 (第1報) わい性台リンゴ苗木のフェザー発生に及ぼすBA剤の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=4 cd-vols= no-issue= article-no= start-page=27 end-page=35 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=カキ,`平核無'果実の脱法に関する小試験 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=4 cd-vols= no-issue= article-no= start-page=24 end-page=26 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ブドウ,"キャンベル･アーリー"における品質向上と栽培の省力化に関する研究 第4報 簡易ビニール被覆が新梢の初期生長及び果実の成熟に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=4 cd-vols= no-issue= article-no= start-page=16 end-page=23 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=マスカットブドウ温室における未利用エネルギーの開発(予報) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=4 cd-vols= no-issue= article-no= start-page=11 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=果実発育中･後期の摘･整房がブドウの外観的品質に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=3 cd-vols= no-issue= article-no= start-page=17 end-page=22 dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=19801220 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=マスカット栽培における2,3の技術改善と生育反応 en-subtitle= kn-subtitle= en-abstract= kn-abstract=本農場のマスカット栽培においては経営的判断から8月上,中旬の出荷を目標に加温栽培した。加温栽堵に当たっては1月中旬加温した。ビニール内張りによる省エネ効果が大であるので自動カーテンの設置が望まれる。その際,除湿方法を検討する必要がある。新梢本数は主枝の片側15cmごとに1本,葉面積指数2.5～3.0程度に増しても良かろう。根の活力増大が望まれ,有機資材の投入により土壌の理化学性の改善が必要である。 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=3 cd-vols= no-issue= article-no= start-page=10 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=19801220 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ブドウ,'キャンベル･アーリー'における品質向上と栽培の省力化に関する研究 第III報 成熟促進に及ぼす発芽促進剤の塗布,ビニール被覆及びGA散布の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=48 cd-vols= no-issue=1 article-no= start-page=63 end-page=67 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=1976 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Chemical Properties of Milk and Milk Products Produced in Mongolia kn-title=モンゴルの乳および乳製品の化学的性状について en-subtitle= kn-subtitle= en-abstract= kn-abstract=モンゴルよりもち帰ることのできた乳汁試料2点,バター1点およびチーズ様製品5点について一般組成,窒素化合物および脂質構成脂肪酸組成を分析し,わが国における市販の乳製品の分析結果と比較検討した. 馬乳の一般組成は牛乳に比べ蛋白質含量が低く乳糖含量が高い. またモンゴル牛の乳汁組成はホルスタイン乳よりも全固形分含量が高い値であった. 一方チーズ様製品の一般組成は水分含量10.03～16.94%,蛋白質含量13.50～44.25%,脂肪含量12.62～54.94%であり種類によりかなりの変動がみられた. また市販のナチュラルチーズの分析結果とかなりの相違がみられたが,これは原料乳と製造方法が異なるためと考えられる. モンゴルチーズの全窒素含量は21.16～69.36mg/g,水溶性窒素含量は1.27～9.49mg/gであり,熟成指数は3.0～15.5の範囲にあった. これらは市販のゴーダチーズに比べ一般にかなり低い値であった. 一方脂質構成脂肪酸については,牛乳と馬乳で構成脂肪酸の種類に相違がみられ,馬乳脂質の脂肪酸組成は牛乳脂質のそれに比較してC4:0とC6:0酸が存在せず,C18:0酸含量が低く,C18:1,C18:2およびC18:3酸の不飽和脂肪酸含量が高い特徴を示した. またバターおよびチーズ様製品の脂質構成脂肪酸組成は牛乳脂質の脂肪酸組成と本質的なちがいはみられなかった。 en-copyright= kn-copyright= en-aut-name=NakaeToshitaka en-aut-sei=Nakae en-aut-mei=Toshitaka kn-aut-name=中江利孝 kn-aut-sei=中江 kn-aut-mei=利孝 aut-affil-num=1 ORCID= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=2 ORCID= en-aut-name=MiyamotoTaku en-aut-sei=Miyamoto en-aut-mei=Taku kn-aut-name=宮本拓 kn-aut-sei=宮本 kn-aut-mei=拓 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=22 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=197912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ブドウ、'キャンベル･アーリー'の品質向上と栽培の省力化に関する研究 第II報 GA散布と整房の併用による摘粒省力化と収穫果の形態的品質 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=土居川俊二 kn-aut-sei=土居川 kn-aut-mei=俊二 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=17 end-page=21 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=197912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ブドウ、'キャンベル･アーリー'の品質向上と栽培の省力化に関する研究 第1報 花穂の切り込み及びGA散布による摘粒省力化 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=土居川俊二 kn-aut-sei=土居川 kn-aut-mei=俊二 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=1 cd-vols= no-issue= article-no= start-page=7 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=197812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=マスカット・オブ・アレキサンドリアの主枝上の潜芽に対する萌芽促進処理 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中野幹夫 kn-aut-sei=中野 kn-aut-mei=幹夫 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松田政紀 kn-aut-sei=松田 kn-aut-mei=政紀 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡衛 kn-aut-sei=片岡 kn-aut-mei=衛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=1 article-no= start-page=33 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=1973 dt-pub=1973 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of Diethylstilbestrol-Testosterone Combination on Fattening Steer of the Japanese Black Breed and Estrogen Level in the Blood Serum kn-title=和牛の若令去勢牛の肥育に対するDiethylstilbestrolおよびTestosterone併用の効果ならびに血中エストロゼンの量 en-subtitle= kn-subtitle= en-abstract= kn-abstract=和牛の肥育に対するdiethylstilbestrol(DES)とtestosteroneの組合せの結果を研究した. このホルモンの組合せとしてRapigainを用いた,Rapigainは1ドーズ中にDES 24mgおよびtestostererone120mgを含むところの肥育剤である. 3頭の牛にRapigain 1ドーズずつを70日間隔で3回耳根部皮下に注入し,最後の注入後70日でと殺した. 別の3頭を対照区とした. Rapigainを注射した区の牛の増体は210日にわたる肥育期間中,対照医の牛のそれよりも優れていた. 1回の注射の効果は初めの20日間が最大で,その後は漸減し,40日過ぎまで続いた. 尾根部の挙上や乳頭の肥大などの副作用は起らなかった. 卵剔マウスの膣内注入による膣垢反応によりRapigain処理50～70日後の牛の血清中のestrogenの検定を行なったがestrogenの残留は検知されなかった。 en-copyright= kn-copyright= en-aut-name=WadaHiroshi en-aut-sei=Wada en-aut-mei=Hiroshi kn-aut-name=和田宏 kn-aut-sei=和田 kn-aut-mei=宏 aut-affil-num=1 ORCID= en-aut-name=YuharaMasataka en-aut-sei=Yuhara en-aut-mei=Masataka kn-aut-name=湯原正高 kn-aut-sei=湯原 kn-aut-mei=正高 aut-affil-num=2 ORCID= en-aut-name=KataokaAkira en-aut-sei=Kataoka en-aut-mei=Akira kn-aut-name=片岡章 kn-aut-sei=片岡 kn-aut-mei=章 aut-affil-num=3 ORCID= en-aut-name=SadaShoji en-aut-sei=Sada en-aut-mei=Shoji kn-aut-name=佐田昭治 kn-aut-sei=佐田 kn-aut-mei=昭治 aut-affil-num=4 ORCID= en-aut-name=InokakeTakeshi en-aut-sei=Inokake en-aut-mei=Takeshi kn-aut-name=猪掛武 kn-aut-sei=猪掛 kn-aut-mei=武 aut-affil-num=5 ORCID= en-aut-name=OguraYoshio en-aut-sei=Ogura en-aut-mei=Yoshio kn-aut-name=小倉与四夫 kn-aut-sei=小倉 kn-aut-mei=与四夫 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=広島県油木種畜場 affil-num=4 en-affil= kn-affil=広島県油木種畜場 affil-num=5 en-affil= kn-affil=広島県油木種畜場 affil-num=6 en-affil= kn-affil=広島県油木種畜場 END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue=1 article-no= start-page=41 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=1972 dt-pub=1972 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Inhibitory Effect by Egg White Lysozyme on Growth of Some Bacteria in Milk kn-title=卵白リゾチーム添加牛乳における細菌の抑制について en-subtitle= kn-subtitle= en-abstract= kn-abstract=牛乳の代表的な高,中および低温菌とみられるB.subtilis,S.lactisおよびグラム陰性の低温性桿菌の3菌株を供試し,脱脂乳中における卵白リゾチームの抑制効果を検討した. B.subtilisは45℃,S.lactisは35℃で24時間培養後,それぞれリゾチーム濃度0.025％および0.05％以上で抑制効果が認められた. そしてリゾチーム濃度（0～0.1％）の高いほどその効果は大きかったが,培養の経過に伴なって抑制効果は減退した. 低温菌は25℃に培養した場合,リゾチーム濃度0.1％でもまったく抑制効果は認められなかった. また自然汚染状態の生乳について別に行なった実験においても,抑制効果が認められなかった。 en-copyright= kn-copyright= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=1 ORCID= en-aut-name=NakaeToshitaka en-aut-sei=Nakae en-aut-mei=Toshitaka kn-aut-name=中江利孝 kn-aut-sei=中江 kn-aut-mei=利孝 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=38 cd-vols= no-issue=1 article-no= start-page=59 end-page=64 dt-received= dt-revised= dt-accepted= dt-pub-year=1971 dt-pub=1971 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Properties of Thermoduric Bacteria from Raw Milk for Fermented Milk Beverage kn-title=醗酵乳用原料乳から分離した耐熱性細菌の性状について en-subtitle= kn-subtitle= en-abstract= kn-abstract=醗酵乳用原料生乳および一部の市販牛乳,計50点から63℃,30分加熱で生存する菌株74株を分離し,その一般性状とタンパク質および脂肪分解性を検索した. その結果から同定した菌群はすべてBacillus属であり,B.cereus,B.subtilis,B.pumilusの順に多く検出された. これらの菌株は,タンパク分解力が大であったが,脂肪分解力は全般的に低かった. 代表的分離菌株のうち,63℃,30分または85℃,20分加熱処理における耐熱性のとくに高い菌株はB.megaterium,B.subtilis,B.cereus等に属する数株であったが,100℃,10分加熱ではその発育細胞の耐熱性は認められなかった. 加糖酸乳飲料に実際に接種して38℃,6日間培養した結果では,38℃,24時間培養菌液の接種において,一部の例にわずかな異常が認められたが,市販条件の同種の製品では異常が起らないものと結論された。 en-copyright= kn-copyright= en-aut-name=NakaeToshitaka en-aut-sei=Nakae en-aut-mei=Toshitaka kn-aut-name=中江利孝 kn-aut-sei=中江 kn-aut-mei=利孝 aut-affil-num=1 ORCID= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=2 ORCID= en-aut-name=HanadaHideo en-aut-sei=Hanada en-aut-mei=Hideo kn-aut-name=花田英雄 kn-aut-sei=花田 kn-aut-mei=英雄 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=1 article-no= start-page=51 end-page=55 dt-received= dt-revised= dt-accepted= dt-pub-year=1969 dt-pub=1969 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An Evaluation of the Tetra-Serum Hydrometric Method for Detecting Added Water in Milk kn-title=テトラ乳清比重法による牛乳の加水試験の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The Tetra-serum hydrometric method as the official routine test for detecting added water in milk was evaluated with special reference to its accuracy and detailed procedure. In experiments with raw milk samples collected in the southern region of Okayama prefecture, it has been shown that the faultiness of turbid serum occurred frequently in the case of the official method is due to an insufficient concentration of acetic acid for preparing milk serum. This fault was improved not by the technical modification for separating milk serum, but by the use of 35% acetic acid instead of 20% in the official method. From 41 samples of normal milk serum prepared by the modified method, the average value and standard deviation of the specific gravity were calculated. The value is 1.0304 ±0.00132. Regression equation of the specific gravity of milk serum on added water ratio was obtained from the experiment of adding water to authenticated milk samples. It was concluded that milk serum samples having specific gravity not over 1.0260 may possibly contain more than 10 per cent of added water. en-copyright= kn-copyright= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=1 ORCID= en-aut-name=KawaseKenzo en-aut-sei=Kawase en-aut-mei=Kenzo kn-aut-name=川瀬兼三 kn-aut-sei=川瀬 kn-aut-mei=兼三 aut-affil-num=2 ORCID= en-aut-name=NakaeToshitaka en-aut-sei=Nakae en-aut-mei=Toshitaka kn-aut-name=中江利孝 kn-aut-sei=中江 kn-aut-mei=利孝 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=1 article-no= start-page=43 end-page=47 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=1968 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An Evaluation of the Resazurin Test Paper Method for Determining the Sanitary Quality of Raw Milk kn-title=レサズリン還元試験紙による原料乳の汚染度判定法の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A new reduction method for determining the sanitary quality of raw milk, which in called the resazurin test paper method; was evaluated comparing with the conventioal resazurin test tube method. The experimental results of the standard plate count method and two types of the resazurin reduction test using sixty samples of raw milk showed a high correlation between standard plate counts and grade number of resazurin test paper. The regression formula was obtained to estimate the standard plate counts from the grade number of resazurin paper. It may be concluded that the resazurin test paper method is very convenient and as good as the conventional test tube method. en-copyright= kn-copyright= en-aut-name=NakaeToshitaka en-aut-sei=Nakae en-aut-mei=Toshitaka kn-aut-name=中江利孝 kn-aut-sei=中江 kn-aut-mei=利孝 aut-affil-num=1 ORCID= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=1 article-no= start-page=63 end-page=67 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=1959 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Raw Milk utilized in Okayama Prefecture. : The Milk-solids Calculating Formula. kn-title=岡山県の原料乳について 乳固形分算定式の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Statistical investigations of various milk-solids calculating formulas had been performed with 228 samples of Holstein's milk during June in 1956 to Dec. in 1958. The specific gravities and fat contents of them lowered slightly in summar, but their SNF contents decreased remarkedly in the season. Then, significant difference was also observed in summar between the calculated and determined milk-solids contents. This fact was resulted from the lowering of SNF content, so the use of correcting factor was neccessary to obtained better results. Similar results were observed in October's samples. There were no significant differences in the chemical components of milks colected from the older, pre-war, experienced farmers and unaccustomed new ones. en-copyright= kn-copyright= en-aut-name=ImamuraTsuneaki en-aut-sei=Imamura en-aut-mei=Tsuneaki kn-aut-name=今村経明 kn-aut-sei=今村 kn-aut-mei=経明 aut-affil-num=1 ORCID= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=2 ORCID= en-aut-name=KanoKeiichi en-aut-sei=Kano en-aut-mei=Keiichi kn-aut-name=加納奎一 kn-aut-sei=加納 kn-aut-mei=奎一 aut-affil-num=3 ORCID= en-aut-name=SuzukiKiyoshi en-aut-sei=Suzuki en-aut-mei=Kiyoshi kn-aut-name=鈴木聖 kn-aut-sei=鈴木 kn-aut-mei=聖 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山県衛生研究所 en-keyword=原料乳 kn-keyword=原料乳 en-keyword=乳固形分算定式 kn-keyword=乳固形分算定式 END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue=1 article-no= start-page=37 end-page=41 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=1958 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the quality of raw milk utilized in Okayama prefacture. : Bacterial count. kn-title=岡山県の原料乳について 細菌数の部 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bacterial investigation has been performed as the previous report. Coli form bacteria was determined by positive Presumptive test with desoxycholate agar. Total bacterial count was represented with individual count (IMC) and clump count (CMC) by direct microscopic method. The ratio of IMC/CMC was calculated to obtained some knowledges of bacterial growth. As the results, it was ascertained that the bacterial count of these samples and the contamination of coli form bacteria were remarkedly. Milk temperature was almost equal to the atmospheric temperature. From this, we concluded that the cooling of milk, especially at farmers, was important to improve the bacteriological quality of milk at this area. en-copyright= kn-copyright= en-aut-name=ImamuraTsuneaki en-aut-sei=Imamura en-aut-mei=Tsuneaki kn-aut-name=今村経明 kn-aut-sei=今村 kn-aut-mei=経明 aut-affil-num=1 ORCID= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=2 ORCID= en-aut-name=SuzukiKiyoshi en-aut-sei=Suzuki en-aut-mei=Kiyoshi kn-aut-name=鈴木聖 kn-aut-sei=鈴木 kn-aut-mei=聖 aut-affil-num=3 ORCID= en-aut-name=NagaoHiroshi en-aut-sei=Nagao en-aut-mei=Hiroshi kn-aut-name=長尾寛 kn-aut-sei=長尾 kn-aut-mei=寛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山県衛生研究所 affil-num=4 en-affil= kn-affil=岡山県衛生研究所 END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue=1 article-no= start-page=29 end-page=35 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=1958 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the quality of raw milk utilized in Okayama prefacture. : Chemical components. kn-title=岡山県の原料乳について 化学的組成の部 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Chemical investigation of milk which had been consumed in Okayama prefacture from Agust in 1956 to June 1957 has been done. About 170 samples were collected at 10 regions (A-J in Fig. 1), and pH, titratable acidity, fat content by Gerber method, protein content by Kjedahl method, lactose content by Lane-Eynone method and milk solid of them were determined. Results obtained are summarised as follows; 1) The great part of samples were within the range of 3.20～3.70% of fat, 2.60～3.30% of protein, 4.10～4.40% of lactose, and 0.13～0.16% of acidity, respectively. On the average of them, the fat content was higher than that of whole land and the lactose content was slightly lower. 2) In summer, the decrease of protein content was remarkedly but the fat content was even in all seasons. en-copyright= kn-copyright= en-aut-name=ImamuraTsuneaki en-aut-sei=Imamura en-aut-mei=Tsuneaki kn-aut-name=今村経明 kn-aut-sei=今村 kn-aut-mei=経明 aut-affil-num=1 ORCID= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=2 ORCID= en-aut-name=SuzukiKiyoshi en-aut-sei=Suzuki en-aut-mei=Kiyoshi kn-aut-name=鈴木聖 kn-aut-sei=鈴木 kn-aut-mei=聖 aut-affil-num=3 ORCID= en-aut-name=NagaoHiroshi en-aut-sei=Nagao en-aut-mei=Hiroshi kn-aut-name=長尾寛 kn-aut-sei=長尾 kn-aut-mei=寛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山県衛生研究所 affil-num=4 en-affil= kn-affil=岡山県衛生研究所 END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue=1 article-no= start-page=41 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=1958 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the lactic acid bacteria survived in milk and milk products. kn-title=牛乳及び乳製品中に存在する乳酸菌について en-subtitle= kn-subtitle= en-abstract= kn-abstract=1.我が国に於て生産される牛乳及び乳製品の一部について乳酸菌の分布を調べたところStr. lactis類似の球菌が大部分であつた.プロセスチーズでは長い熟成期間中に原料乳中の乳酸菌やスターターに用いた乳酸菌とは異つた菌の分布を示す様になつている.粉乳の場合には製造工程にspray dringがあるために高温性菌が多いことが認められた.バター中の乳酸菌も原料乳中の分布とは趣を異にしているが,これは乳酸菌にとつて栄養的に偏つていることや食塩濃度が高いことが原因かも知れない.2.在来のものに比し優秀な酸生成または蛋白分解性を示す菌を分離出来なかつた.蛋白分解性に関しては培地のpHが影響するところ大であつて,乳糖分解により生成する乳酸と蛋白分解により生成する塩基性化合物との相関関係によつて乳酸菌の醗酵状態が変化する.このことは特にチーズの場合に重要であると思われる.即ち乳酸生成が増大すれば酸性に傾いて旨味物質の生成が遅れ,蛋白分解が盛んになれば乳酸菌の生育が抑制されて腐敗し易くなる.従つて平衡状態如何によつて製品の品質が支配される.3.diacetyl量からみて優秀な香気生成菌を数株発見出来た.これ等の菌は香気生成に秀れているのみでなく,生酸力も顕著である.従つて単独使用出来るスターターとして実用化し得る可能性がある.在来の香気生成菌が酸生成菌と共棲させる必要のある点を補つている。 en-copyright= kn-copyright= en-aut-name=ImamuraTsuneaki en-aut-sei=Imamura en-aut-mei=Tsuneaki kn-aut-name=今村経明 kn-aut-sei=今村 kn-aut-mei=経明 aut-affil-num=1 ORCID= en-aut-name=KataokaKei en-aut-sei=Kataoka en-aut-mei=Kei kn-aut-name=片岡啓 kn-aut-sei=片岡 kn-aut-mei=啓 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 END