start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=357 end-page=371 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Proposals for Supporting Children’s Adaptation in School Mergers and Closures kn-title=学校統廃合における児童の適応支援策の提言 en-subtitle= kn-subtitle= en-abstract=The purpose of this study is to examine the impact of school mergers and closures on children through a literature review and field survey and to propose strategies for supporting children's adaptation to the resulting environmental transitions. First, a literature review on school mergers and closures indicated that such experiences could influence children's later interpersonal relationships and increase stress responses. However, research on the impact of school mergers and closures on children remains limited, with insufficient understanding of their psychological effects on children. Next, interviews conducted as part of a field survey revealed that school mergers and closures could be significant sources of stress for children. Based on these findings, we recommends multi-level support measures targeting individuals, classes, grades, and entire schools, primarily through special activities, to help mitigate the impact of these transitions on children. kn-abstract=本研究の目的は，学校統廃合に係る文献検索および実態調査を通して，学校統廃合という環境移行が児童に与える影響について検討し，学校統廃合がもたらす環境移行に対する児童の適応支援策について提言することである。まず，学校統廃合に係る文献検索を行った結果，学校統廃合の経験が児童生徒のその後の人間関係形成やストレス反応の増加に影響を与えている可能性が示された。しかし，学校統廃合が児童に与える影響に関する研究は非常に少なく，統廃合の経験が児童に与える心理的影響については十分に解明されていないことがわかった。次に，実態調査として行ったインタビューにおいて，学校統廃合が児童にとって大きなストレス要因となる可能性があることがわかった。これらの現状を踏まえて，学校統廃合が児童に与える影響を和らげるため，特別活動を中心として，個人・学級・学年・学校レベルでの具体的な取組を提案した。 en-copyright= kn-copyright= en-aut-name=IKEDAYuka en-aut-sei=IKEDA en-aut-mei=Yuka kn-aut-name=池田祐加 kn-aut-sei=池田 kn-aut-mei=祐加 aut-affil-num=1 ORCID= en-aut-name=IZUMITsuguyuki en-aut-sei=IZUMI en-aut-mei=Tsuguyuki kn-aut-name=伊住継行 kn-aut-sei=伊住 kn-aut-mei=継行 aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Education (Professional Degree Corse), Okayama University kn-affil=岡山大学大学院教育学研究科大学院生 affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=岡山大学学術研究院教育学域 en-keyword=学校統廃合 (School Consolidation) kn-keyword=学校統廃合 (School Consolidation) en-keyword=児童 (Children) kn-keyword=児童 (Children) en-keyword=人間関係形成 (Relationship Building) kn-keyword=人間関係形成 (Relationship Building) en-keyword=ストレス (Stress) kn-keyword=ストレス (Stress) en-keyword=特別活動 (Special Activities) kn-keyword=特別活動 (Special Activities) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=133 end-page=145 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Image of Mushroom Created by Junior High School Science Textbooks: Suggestions for Learning about Mushroom from Diachronic Surveys kn-title=中学校理科教科書がつくり上げてきたきのこ像　―通時的調査から得るきのこを巡る学習への示唆― en-subtitle= kn-subtitle= en-abstract=　In this paper, we examined the image of mushroom in postwar junior high school science textbooks from four perspectives: (1) which species of mushroom were covered, (2) whether they were classified as plants or not, (3) what makes up the body of a mushroom, and (4) how they functioned in an ecosystem. The 47 species were identified through a periodic survey. Although a total of 47 species have appeared in science textbooks, we pointed out that in recent years, the focus has shifted to the role of mushroom as decomposers, rather than to species awareness. We also pointed out that although mycorrhizal fungi have been discussed in textbooks, there was no reference to the perspective in a plant-fungal symbiosis, which raises the possibility of developing learning that aims to understand symbiosis/interactions within a nature ecosystem. kn-abstract=　本稿では，戦後中学校理科検定教科書におけるきのこの扱われ方，すなわち学習者が受け取ることになるきのこ像について，①どのようなきのこが扱われてきたのか，②植物に分類されているか否か，③きのこのからだは何で形成されているのか，④生態系における働きの四つの観点から，通時的な調査によって明らかにした。全47種がこれまでの理科教科書で登場してきたが，近年は種への意識というよりも，きのこが分解者としての役割を持つことにのみ焦点が当てられてきていることを指摘した。また，これまで教科書においては菌根性のきのこ自体について取り上げられつつも，その生態系における相利共生の観点への言及はないことから，相利共生の理解を目指す学習の開発が可能性として浮かび上がってくることも指摘した。 en-copyright= kn-copyright= en-aut-name=TAKAGIRisa en-aut-sei=TAKAGI en-aut-mei=Risa kn-aut-name=髙木里彩 kn-aut-sei=髙木 kn-aut-mei=里彩 aut-affil-num=1 ORCID= en-aut-name=IKEDAMasafumi en-aut-sei=IKEDA en-aut-mei=Masafumi kn-aut-name=池田匡史 kn-aut-sei=池田 kn-aut-mei=匡史 aut-affil-num=2 ORCID= en-aut-name=YAMAMOTOMasaya en-aut-sei=YAMAMOTO en-aut-mei=Masaya kn-aut-name=山本将也 kn-aut-sei=山本 kn-aut-mei=将也 aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Education (Professional Degree Corse), Okayama University kn-affil=岡山大学大学院教育学研究科大学院生 affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=岡山大学学術研究院教育学域 affil-num=3 en-affil=Hyogo University of Teacher Education kn-affil=兵庫教育大学大学院学校教育研究科 en-keyword=菌類 (Fungus) kn-keyword=菌類 (Fungus) en-keyword=菌根菌 (Mycorrhizal Fungi) kn-keyword=菌根菌 (Mycorrhizal Fungi) en-keyword=腐生菌 (Saprobic Fungi) kn-keyword=腐生菌 (Saprobic Fungi) en-keyword=相利共生 (Symbiosis) kn-keyword=相利共生 (Symbiosis) en-keyword=教材史 (History of teaching materials) kn-keyword=教材史 (History of teaching materials) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=119 end-page=132 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Development of Thoughts on the Effective Use of School Libraries and Collaboration with Teacher-Librarians and School Librarians in Japanese Language Arts: From a Survey of the Journal Kyoiku Kagaku Kokugo Kyoiku kn-title=学校図書館の活用と司書教諭・学校司書との協働をめぐる国語教育思潮の展開　―『教育科学国語教育』誌の調査から― en-subtitle= kn-subtitle= en-abstract=　School libraries are mentioned by government guidelines for teaching, and it is also closely related to Japanese language arts. Previous studies have reported the necessity of collaboration with teacher-librarians and school librarians. However, there has been no study of what kind of collaboration has been conducted in Japanese language arts to date. Therefore, the purpose of this study is to examine how school libraries are utilized in Japanese language arts based on a survey of educational journals, and to organize references to teacher-librarians and school librarians. As a result, we pointed out that while school libraries have been utilized in Japanese language arts in elementary and junior high schools, the collaboration with teacher-librarians and school librarians may not have been focused on, and that the reason for this is the lack of human resources, while some valuable collaborations can be found. kn-abstract=　学校図書館は，学習指導要領でも触れられており，国語科との関連も深い。また先行研究では，司書教諭や学校司書との協働の必要性が訴えられている。しかしこれまでの国語教育では，どのような協働がなされていたのかという検討がなされていない。そこで，本研究では，教育雑誌の調査をもとに，国語科においては，学校図書館がどのように活用されてきたのか，司書教諭や学校司書との協働はどのような態度がとられてきたのかを明らかにすることを目的とした。調査では，図書館に言及している論文や学校図書館を活用した実践・指導例を抽出し，分析した。実践・指導例の分析からは，小・中学校の国語科において学校図書館は活用されてきた一方で，司書教諭や学校司書との協働には着目が及んでいない状況が明らかになった。また，司書教諭や学校司書に関する言及からは，人的リソースにその原因を求める思潮が窺えたものの，価値ある協働も見受けられることを指摘した。 en-copyright= kn-copyright= en-aut-name=SAISHOYumi en-aut-sei=SAISHO en-aut-mei=Yumi kn-aut-name=最相有未 kn-aut-sei=最相 kn-aut-mei=有未 aut-affil-num=1 ORCID= en-aut-name=IKEDAMasafumi en-aut-sei=IKEDA en-aut-mei=Masafumi kn-aut-name=池田匡史 kn-aut-sei=池田 kn-aut-mei=匡史 aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Education（Professional Degree Corse），Okayama University kn-affil=岡山大学大学院教育学研究科大学院生 affil-num=2 en-affil=Faculty of Education，Okayama University kn-affil=岡山大学学術研究院教育学域 en-keyword=雑誌調査 (survey of journals) kn-keyword=雑誌調査 (survey of journals) en-keyword=読書指導 (reading instruction) kn-keyword=読書指導 (reading instruction) en-keyword=探究的な学習 (inquiry-based learning) kn-keyword=探究的な学習 (inquiry-based learning) en-keyword=国語教育史 (history of Japanese Language Arts) kn-keyword=国語教育史 (history of Japanese Language Arts) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=33 end-page=44 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Systematic Improvement of Lessons in Elementary Schools –A Case Study of Japanese Language Instruction Aimed at Realizing the “Ideal Child Image”– kn-title=小学校における組織的な授業改善のあり方　〜「目指す子ども像」実現に向けた国語科指導を事例として〜 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　本研究の目的は、「目指す子ども像」実現に向けた国語科の授業づくりの具体を検討し、小学校における組織的な授業改善のあり方を提言することにある。具体的には、「目指す子ども像」実現に向けた国語科の授業づくりを通して、今の社会が小学校教育に求める特色ある授業づくりの進め方を明らかにするため、勤務校である早島町立早島小学校に所属する教師の授業づくりを対象に事例研究を展開した。検討を通じて明らかになったことは、授業づくりにおける教師の思考・実践過程と、これらを実践者が反省的に捉え直すための「目指す子ども像」による言語活動具体化の手立てである。さらに、授業づくりの組織・系統性は、他学年教師の役割によってもたらされることが確認されたことから、それらを踏まえつつ、「目指す子ども像」実現に向けた授業づくりのあり方を体系化した。そうすることで、小学校における組織的な授業改善を進めていくための可能性が見出された。 en-copyright= kn-copyright= en-aut-name=KOMOTOAkihiro en-aut-sei=KOMOTO en-aut-mei=Akihiro kn-aut-name=河本章宏 kn-aut-sei=河本 kn-aut-mei=章宏 aut-affil-num=1 ORCID= en-aut-name=MIYAMOTOKoji en-aut-sei=MIYAMOTO en-aut-mei=Koji kn-aut-name=宮本浩治 kn-aut-sei=宮本 kn-aut-mei=浩治 aut-affil-num=2 ORCID= en-aut-name=IKEDAMasafumi en-aut-sei=IKEDA en-aut-mei=Masafumi kn-aut-name=池田匡史 kn-aut-sei=池田 kn-aut-mei=匡史 aut-affil-num=3 ORCID= en-aut-name=MATUDASatoshi en-aut-sei=MATUDA en-aut-mei=Satoshi kn-aut-name=松田聡 kn-aut-sei=松田 kn-aut-mei=聡 aut-affil-num=4 ORCID= affil-num=1 en-affil=Hayashima Elementary School (Graduate School of Education (Professional Degree Corse), Okayama University) kn-affil=岡山大学大学院教育学研究科大学院生 affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=岡山大学学術研究院教育学域 affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil=岡山大学学術研究院教育学域 affil-num=4 en-affil=Faculty of Education, Okayama University kn-affil=岡山大学学術研究院教育学域 en-keyword=目指す子ども像 (The school's educational goals) kn-keyword=目指す子ども像 (The school's educational goals) en-keyword=価値目標 (into value-objectives) kn-keyword=価値目標 (into value-objectives) en-keyword=国語学力 (Japanese language ability) kn-keyword=国語学力 (Japanese language ability) en-keyword=カリキュラムマネジメント (Curriculum Management) kn-keyword=カリキュラムマネジメント (Curriculum Management) en-keyword=組織・系統性 (Organization and Systematic) kn-keyword=組織・系統性 (Organization and Systematic) END start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue=1 article-no= start-page=4 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250116 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Maternal smoking during infancy increases the risk of allergic diseases in children: a nationwide longitudinal survey in Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background The incidence of allergic diseases has been increasing in Japan. In particular, a serious decline in the age of onset of allergic rhinitis has been observed. Passive smoking from parental smoking has a significant impact on children’s health; however, it is difficult to restrict smoking in the home. While various studies have previously reported on the relationship between passive smoking and the development of allergic diseases in children. However, there have been no reports on passive smoking and allergic diseases on a national scale.
Methods Using Japanese national longitudinal survey data (n = 38,444) for newborns born between May 10 and 24, 2010, we assessed parental smoking habits when their children were 6 months old and investigated the association with the development of allergic diseases until the age of 5.5 years. The risk ratios and 95% confidence intervals for the development of different allergic diseases were analyzed after adjusting for potential confounders using Poisson regression with a robust error variance.
Results The risk ratio for developing allergic rhinitis/allergic conjunctivitis (AR/AC) in children was significantly higher in the maternal smoking groups ( ≦ 10 cigarettes/day; RR 1.15, 95% CI 1.02–1.30; ≧11 cigarettes/day; RR 1.16, 95% CI 0.93–1.44). Furthermore, associations were found between the maternal smoking group in the presence of paternal smoking and the risk of developing bronchial asthma ( ≦ 10, RR 1.33 95% CI 1.17–1.52; ≧11, RR 1.71 95% CI 1.38–2.1), food allergy ( ≦ 10, RR 1.36 95% CI 1.12–1.63; ≧11, RR 1.25 95% CI 0.84–1.86), atopic dermatitis ( ≦ 10, RR 1.42 95% CI 1.22–1.66; ≧11, RR 1.6 95% CI 1.2–2.13), and AR/AC ( ≦ 10, RR 1.21 95% CI 1.07–1.36; ≧11, RR 1.35 95% CI 1.09–1.67).
Conclusions Maternal smoking during infancy increases the risk of developing AR/AC in children. Considering paternal smoking, maternal smoking further increased the risk of developing allergic diseases in children, suggesting that reducing parental smoking at home may reduce the risk of developing allergic diseases in children. en-copyright= kn-copyright= en-aut-name=ShigeharaKenji en-aut-sei=Shigehara en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsumotoNaomi en-aut-sei=Matsumoto en-aut-mei=Naomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TsugeMitsuru en-aut-sei=Tsuge en-aut-mei=Mitsuru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UdaKazuhiro en-aut-sei=Uda en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SaitoYukie en-aut-sei=Saito en-aut-mei=Yukie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YashiroMasato en-aut-sei=Yashiro en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IkedaMasanori en-aut-sei=Ikeda en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TsukaharaHirokazu en-aut-sei=Tsukahara en-aut-mei=Hirokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Pediatric Acute Diseases, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=Allergic rhinitis kn-keyword=Allergic rhinitis en-keyword=Bronchial asthma kn-keyword=Bronchial asthma en-keyword=Atopic dermatitis kn-keyword=Atopic dermatitis en-keyword=National cohort study kn-keyword=National cohort study en-keyword=Passive smoking kn-keyword=Passive smoking END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue= article-no= start-page=265 end-page=279 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240329 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Systematic Improvement of Teaching to Realize the School’s Educational Goals -Japanese Language Instruction as the core of the Program- kn-title=「目指す生徒像」を意識した組織的な授業改善 ～「自ら学び、思いや考えを伝え合う力」を育む国語科指導を軸として～ en-subtitle= kn-subtitle= en-abstract= kn-abstract=　本研究の目的は、「目指す生徒像」を意識した学校の組織改善の具体を報告し、そのあり方を提言することにある。いつの時代においても、授業改善は教師に求められることである。教師は、よりよい授業をしたいと願うものの、本質的に授業はおもしろくないものとして、子どもたちには認識されているのが現状である。本研究では、共有ビジョンである「目指す生徒像」を軸とした協働的な授業改善の取り組みを報告する。そして、「目指す生徒像」を教職員が一丸となって作り、解釈、実践、検討していく営みの中で、生徒の実態や授業の問題点を明確に認識し、同じ視点での授業の改善や学校の組織力の向上につながる可能性を見出すこととする。さらに、こうした取り組みを進めていく中で、教師一人ひとりのメンタル・モデルにどのようにアプローチしていくのかということの視座も明らかにしていくこととする。 en-copyright= kn-copyright= en-aut-name=OKADANami en-aut-sei=OKADA en-aut-mei=Nami kn-aut-name=岡田奈未 kn-aut-sei=岡田 kn-aut-mei=奈未 aut-affil-num=1 ORCID= en-aut-name=MIYAMOTOKoji en-aut-sei=MIYAMOTO en-aut-mei=Koji kn-aut-name=宮本浩治 kn-aut-sei=宮本 kn-aut-mei=浩治 aut-affil-num=2 ORCID= en-aut-name=IKEDAMasafumi en-aut-sei=IKEDA en-aut-mei=Masafumi kn-aut-name=池田匡史 kn-aut-sei=池田 kn-aut-mei=匡史 aut-affil-num=3 ORCID= en-aut-name=MAKINOShigeko en-aut-sei=MAKINO en-aut-mei=Shigeko kn-aut-name=槇野滋子 kn-aut-sei=槇野 kn-aut-mei=滋子 aut-affil-num=4 ORCID= affil-num=1 en-affil=Ibara Junior High School (Graduate School of Education (Professional Degree Corse), Okayama University) kn-affil=岡山大学大学院教育学研究科大学院生 affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=岡山大学学術研究院教育学域 affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil=岡山大学学術研究院教育学域 affil-num=4 en-affil=Faculty of Education, Okayama University kn-affil=岡山大学学術研究院教育学域 en-keyword=学習する組織 (Learning Organization) kn-keyword=学習する組織 (Learning Organization) en-keyword=授業改善 (Systematic improvement of teaching) kn-keyword=授業改善 (Systematic improvement of teaching) en-keyword=目指す生徒像 (The school's educational goals) kn-keyword=目指す生徒像 (The school's educational goals) en-keyword=教師のメンタル・モデル (Mental Models of Teachers) kn-keyword=教師のメンタル・モデル (Mental Models of Teachers) en-keyword=国語科指導 (Japanese language instruction) kn-keyword=国語科指導 (Japanese language instruction) END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue= article-no= start-page=103 end-page=117 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240329 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Development of Learning Focusing on the Perspective of “The Situation Narrated” in Japanese Language Arts in High School: A Lesson for Hone to Tane by KAWAKAMI Hiromi kn-title=高等学校国語科における「語りの場」に着目する学習開発 ―川上弘美「ほねとたね」を教材として― en-subtitle= kn-subtitle= en-abstract=　Recently, the instructional theory of reading literary texts has been focusing on " narrative," Furthermore its practice has been reported at the high school level. On the other hand, the lack of accumulation of specific instructional strategies for " narrative" and the lack of accumulation of practices for developing "narrative" learning at the high school level are considered issues in Japanese language arts education research. Therefore, the purpose of this study was to develop a practice that aims to help learners acquire the concept of "narrative," especially a reading perspective that focuses on not only the "narrative perspective" but also the "situation narrated," at the high school level, and to actually develop this practice and verify its value. The specific strategy was to use Hone to Tane written by Kawakami Hiromi as the teaching material, and to consider the "situation narrated" after the learners' evaluation of the likeability toward each character in the teaching material and the writing of reminiscences from the characters' perspectives. The results suggest that specific products were obtained that show that learners were able to critique the "narrative" by focusing on the "situation narrated." kn-abstract=　近年，文学的文章の読みの学習指導論では，「語り」に目が向けられつつあり，高等学校段階でも授業実践が報告されている。一方で，「語り」の具体的な指導方法の蓄積がなされていないことや，高等学校段階での発展的な「語り」の学習の実践の蓄積がなされていないことが，国語教育研究上の課題と捉えられる。そこで本研究では，高等学校段階において，学習者が「語り」概念，特に「語りの視点」だけでなく「語りの場」にも着目するという読みの観点を学習者が獲得することを目指す実践を開発するとともに，それを実際に展開し，その価値を検証することを目的とした。具体的には，川上弘美の「ほねとたね」を教材とし，学習者の登場人物の好感度の評価や回想文作成を踏まえ，「語りの場」を考える実践を展開しその成果を検討した。その結果，本実践を通して学習者は「語り」概念を獲得するとともに，「語りの視点」，「語りの場」にも着目した読みの達成が示唆された。 en-copyright= kn-copyright= en-aut-name=MOTOMURASota en-aut-sei=MOTOMURA en-aut-mei=Sota kn-aut-name=元村綜太 kn-aut-sei=元村 kn-aut-mei=綜太 aut-affil-num=1 ORCID= en-aut-name=MAKINOShigeko en-aut-sei=MAKINO en-aut-mei=Shigeko kn-aut-name=槇野滋子 kn-aut-sei=槇野 kn-aut-mei=滋子 aut-affil-num=2 ORCID= en-aut-name=IKEDAMasafumi en-aut-sei=IKEDA en-aut-mei=Masafumi kn-aut-name=池田匡史 kn-aut-sei=池田 kn-aut-mei=匡史 aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Education (Professional Degree Corse), Okayama University kn-affil=岡山大学教育学研究科大学院生 affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=岡山大学学術研究院教育学域 affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil=岡山大学学術研究院教育学域 en-keyword=読むこと (Reading) kn-keyword=読むこと (Reading) en-keyword=文学国語 (Japanese Language (Literature)) kn-keyword=文学国語 (Japanese Language (Literature)) en-keyword=文学的文章 (Literary texts) kn-keyword=文学的文章 (Literary texts) en-keyword=「語り」 (“Narrative”) kn-keyword=「語り」 (“Narrative”) en-keyword=「語り手」 (“Narrator”) kn-keyword=「語り手」 (“Narrator”) END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=1 article-no= start-page=103 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20231205 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Successful use of dupilumab for egg-induced eosinophilic gastroenteritis with duodenal ulcer: a pediatric case report and review of literature en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background Non-esophageal eosinophilic gastrointestinal disorder (non-EoE-EGID) is a rare disease in which eosinophils infiltrate parts of the gastrointestinal tract other than the esophagus; however, the number of patients with non-EoE-EGID has been increasing in recent years. Owing to its chronic course with repeated relapses, it can lead to developmental delays due to malnutrition, especially in pediatric patients. No established treatment exists for non-EoE-EGID, necessitating long-term systemic corticosteroid administration. Although the efficacy of dupilumab, an anti-IL-4/13 receptor monoclonal antibody, for eosinophilic esophagitis, has been reported, only few reports have demonstrated its efficacy in non-EoE EGIDs.
Case presentation A 13-year-old boy developed non-EoE-EGID with duodenal ulcers, with chicken eggs as the trigger. He was successfully treated with an egg-free diet, proton pump inhibitors, and leukotriene receptor antagonists. However, at age 15, he developed worsening upper abdominal pain and difficulty eating. Blood analysis revealed eosinophilia; elevated erythrocyte sedimentation rate; and elevated levels of C-reactive protein, total immunoglobulin E, and thymic and activation-regulated chemokines. Upper gastrointestinal endoscopy revealed a duodenal ulcer with marked mucosal eosinophilic infiltration. Gastrointestinal symptoms persisted even after starting systemic steroids, making it difficult to reduce the steroid dose. Subcutaneous injection of dupilumab was initiated because of comorbid atopic dermatitis exacerbation. After 3 months, the gastrointestinal symptoms disappeared, and after 5 months, the duodenal ulcer disappeared and the eosinophil count decreased in the mucosa. Six months later, systemic steroids were discontinued, and the duodenal ulcer remained recurrence-free. The egg challenge test result was negative; therefore, the egg-free diet was discontinued. Blood eosinophil count and serum IL-5, IL-13, and eotaxin-3 levels decreased after dupilumab treatment. The serum levels of IL-5 and eotaxin-3 remained within normal ranges, although the blood eosinophil counts increased again after discontinuation of oral prednisolone.
Conclusions Suppression of IL-4R/IL-13R-mediated signaling by dupilumab may improve abdominal symptoms and endoscopic and histologic findings in patients with non-EoE-EGID, leading to the discontinuation of systemic steroid administration and tolerance of causative foods. en-copyright= kn-copyright= en-aut-name=TsugeMitsuru en-aut-sei=Tsuge en-aut-mei=Mitsuru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShigeharaKenji en-aut-sei=Shigehara en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UdaKazuhiro en-aut-sei=Uda en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SaitoYukie en-aut-sei=Saito en-aut-mei=Yukie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YashiroMasato en-aut-sei=Yashiro en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IkedaMasanori en-aut-sei=Ikeda en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TsukaharaHirokazu en-aut-sei=Tsukahara en-aut-mei=Hirokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Pediatric Acute Diseases, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Pediatrics, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=Duodenal ulcer kn-keyword=Duodenal ulcer en-keyword=Dupilumab kn-keyword=Dupilumab en-keyword=Eosinophilic gastroenteritis kn-keyword=Eosinophilic gastroenteritis en-keyword=Eotaxin-3 kn-keyword=Eotaxin-3 en-keyword=Food allergy kn-keyword=Food allergy en-keyword=Interleukin-5 kn-keyword=Interleukin-5 en-keyword=Interleukin-13 kn-keyword=Interleukin-13 en-keyword=Non-esophageal eosinophilic gastrointestinal disorder kn-keyword=Non-esophageal eosinophilic gastrointestinal disorder END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肥満・高脂血症は相乗的に乾癬様皮疹を悪化させる kn-title=Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IKEDAKenta en-aut-sei=IKEDA en-aut-mei=Kenta kn-aut-name=池田賢太 kn-aut-sei=池田 kn-aut-mei=賢太 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=37 cd-vols= no-issue= article-no= start-page=(1) end-page=(12) dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=満洲の現地人向け中国語教科書における「メロスの伝説」 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=池田匡史 kn-aut-sei=池田 kn-aut-mei=匡史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学学術研究院教育学域 END start-ver=1.4 cd-journal=joma no-vol=182 cd-vols= no-issue= article-no= start-page=13 end-page=21 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230224 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Development of Lessons Using Postmodern Picture Books in the Japanese Language Arts Class at High School: To Encourage Students to Make Sense of the Text kn-title=高等学校国語科におけるポストモダン絵本を用いた実践像　―テクストへの意味づけを促すために― en-subtitle= kn-subtitle= en-abstract= kn-abstract=　本稿では，高等学校国語科において，ポストモダン絵本を教材とした実践開発を行い，具体的な実践像を提示するとともに，その成果を検討することで，その教材性の価値の一端を明らかにすることを目的とした。具体的には，ジョン・シェスカ&レイン・スミスによるポストモダン絵本である『三びきのコブタのほんとうの話』を用い，高等学校三年生を対象に実践を開発した。
　結果，本単元の学習によって，読者が自らの立場とは異なる視点に立ったり，語り手の語りに取り込まれないようにしたりするというような読みの視点の獲得がなされていった様子や，主体的にテクストの意味づけを行う様子の具体を示すことができた。またこれらのことを達成できるということが，ポストモダン絵本の教材性の一つとして示唆された。 en-copyright= kn-copyright= en-aut-name=IkedaMasafumi en-aut-sei=Ikeda en-aut-mei=Masafumi kn-aut-name=池田匡史 kn-aut-sei=池田 kn-aut-mei=匡史 aut-affil-num=1 ORCID= en-aut-name=TakedaTomomi en-aut-sei=Takeda en-aut-mei=Tomomi kn-aut-name=竹田智美 kn-aut-sei=竹田 kn-aut-mei=智美 aut-affil-num=2 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=岡山大学学術研究院教育学域 affil-num=2 en-affil=Fukuoka Prefectual Genkai High School kn-affil=福岡県立玄界高等学校 END start-ver=1.4 cd-journal=joma no-vol=180 cd-vols= no-issue= article-no= start-page=39 end-page=47 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220826 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Development of Discussion Instruction with Inevitable Use of ICT in Japanese Language Studies at High School: Setting up a “Non-private Relationship” Place Through Connections Between Different Schools kn-title=高等学校国語科におけるICT 活用に必然性がある話し合い指導の開発 ― 学校間の接続による「私的な関係ではない」場の設定 ― en-subtitle= kn-subtitle= en-abstract= kn-abstract=国語教育学研究における話し合い指導は，現実的な制約から教室内の関係の中で展開されるものにとどまっていた。その結果，公的な関係での話し合いの場が設定されにくい現状にあった。しかしながら，ICTの活用を通して学校間を繋ぐことによって，関係性の築き上げられていない関係での話し合いの場の設定が可能になる。そこで，ICTの活用による文字化資料の作成の効率化などの利点も取り入れながら，実際に県を跨いで高等学校間を接続し，話し合いを行うとともに，その話し合いの対象化を行う実践を開発，展開した。結果，学習者は学校間の接続に肯定的な評価を示すとともに，方法知の獲得の土台となるであろう認識を獲得したことを明らかにした。 en-copyright= kn-copyright= en-aut-name=IkedaMasafumi en-aut-sei=Ikeda en-aut-mei=Masafumi kn-aut-name=池田匡史 kn-aut-sei=池田 kn-aut-mei=匡史 aut-affil-num=1 ORCID= en-aut-name=MitsugiRyota en-aut-sei=Mitsugi en-aut-mei=Ryota kn-aut-name=三樹亮太 kn-aut-sei=三樹 kn-aut-mei=亮太 aut-affil-num=2 ORCID= en-aut-name=SatomuraHiraku en-aut-sei=Satomura en-aut-mei=Hiraku kn-aut-name=里村啓 kn-aut-sei=里村 kn-aut-mei=啓 aut-affil-num=3 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=岡山大学学術研究院教育学域 affil-num=2 en-affil=Kumamoto Prefectual Yatsushiro Agricultural High School, Izumi Branch kn-affil=熊本県立八代農業高等学校泉分校 affil-num=3 en-affil=Yamaguchi Prefectual Houfu-nishi High School kn-affil=山口県立防府西高等学校 en-keyword=話し合い kn-keyword=話し合い en-keyword=文字化資料 kn-keyword=文字化資料 en-keyword=学校間交流 kn-keyword=学校間交流 en-keyword=ICTの活用 kn-keyword=ICTの活用 en-keyword=公的な関係性 kn-keyword=公的な関係性 END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=8 article-no= start-page=1253 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220819 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Novel Lung Growth Strategy with Biological Therapy Targeting Airway Remodeling in Childhood Bronchial Asthma en-subtitle= kn-subtitle= en-abstract= kn-abstract=Anti-inflammatory therapy, centered on inhaled steroids, suppresses airway inflammation in asthma, reduces asthma mortality and hospitalization rates, and achieves clinical remission in many pediatric patients. However, the spontaneous remission rate of childhood asthma in adulthood is not high, and airway inflammation and airway remodeling persist after remission of asthma symptoms. Childhood asthma impairs normal lung maturation, interferes with peak lung function in adolescence, reduces lung function in adulthood, and increases the risk of developing chronic obstructive pulmonary disease (COPD). Early suppression of airway inflammation in childhood and prevention of asthma exacerbations may improve lung maturation, leading to good lung function and prevention of adult COPD. Biological drugs that target T-helper 2 (Th2) cytokines are used in patients with severe pediatric asthma to reduce exacerbations and airway inflammation and improve respiratory function. They may also suppress airway remodeling in childhood and prevent respiratory deterioration in adulthood, reducing the risk of COPD and improving long-term prognosis. No studies have demonstrated a suppressive effect on airway remodeling in childhood severe asthma, and further clinical trials using airway imaging analysis are needed to ascertain the inhibitory effect of biological drugs on airway remodeling in severe childhood asthma. In this review, we describe the natural prognosis of lung function in childhood asthma and the risk of developing adult COPD, the pathophysiology of allergic airway inflammation and airway remodeling via Th2 cytokines, and the inhibitory effect of biological drugs on airway remodeling in childhood asthma. en-copyright= kn-copyright= en-aut-name=TsugeMitsuru en-aut-sei=Tsuge en-aut-mei=Mitsuru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaMasanori en-aut-sei=Ikeda en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TsukaharaHirokazu en-aut-sei=Tsukahara en-aut-mei=Hirokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Pediatric Acute Diseases, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Okayama University School of Medicine kn-affil= affil-num=3 en-affil=Department of Pediatrics, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=chronic obstructive pulmonary disease kn-keyword=chronic obstructive pulmonary disease en-keyword=lung function trajectory kn-keyword=lung function trajectory en-keyword=type 2 inflammation kn-keyword=type 2 inflammation en-keyword=airway remodeling kn-keyword=airway remodeling en-keyword=omalizumab kn-keyword=omalizumab en-keyword=mepolizumab kn-keyword=mepolizumab en-keyword=benralizumab kn-keyword=benralizumab en-keyword=dupilumab kn-keyword=dupilumab END start-ver=1.4 cd-journal=joma no-vol=135 cd-vols= no-issue=2 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=2022215 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Decades-long phylogeographic issues: complex historical processes and ecological factors on genetic structure of alpine plants in the Japanese Archipelago en-subtitle= kn-subtitle= en-abstract= kn-abstract=Mountain regions are important places for biodiversity, where organisms could persist throughout prolonged periods and accumulate genetic divergence as well as promote speciation. Roles of mountains for biodiversity have been exclusively discussed in regions that have specifically diverse species or covered with ice-sheets during the Pleistocene glacial periods, whereas the importance of mountainous regions in East Asia has been less disputed. High mountains in the Japanese Archipelago, located at the eastern edge of the Eurasia continent, have one of southernmost populations of alpine and arctic-alpine plants that are also distributed in the northern Pacific and/or the circumarctic regions. Phylogeographic studies on the Japanese alpine plants have excluded their possible ephemeral occurrence during the current warm period, and rather, suggest persistence of alpine plants throughout several cycles of climate changes in the Pleistocene on high mountains in central Honshu, the main island of the Japanese Archipelago. In this review, I look through decade long phylogeographic studies and show complicated patterns of range dynamics of Japanese alpine plants. In addition, I note recent findings of genetic relationships of Japanese populations of alpine and/or arctic-alpine plants with those in northern regions and their possible ecological divergence in the Japanese Archipelago. Taken together, I provide several issues for understanding historical processes that established distribution of alpine plants following climate changes as well as their diversification and propose importance of Japanese populations of alpine plants on biodiversity in alpine communities across broader range, especially in the northern Pacific region. en-copyright= kn-copyright= en-aut-name=IkedaHajime en-aut-sei=Ikeda en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= en-keyword=Alpine plants kn-keyword=Alpine plants en-keyword=Dispersal kn-keyword=Dispersal en-keyword=Genetic divergence kn-keyword=Genetic divergence en-keyword=East Asia kn-keyword=East Asia en-keyword=Phylogeography kn-keyword=Phylogeography END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=御留帳評定書　目次・凡例・地図・解説 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201302 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=朝鮮通信使饗応関係資料　目次・凡例・地図・解説 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=201003 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=御留帳御船手 目次・凡例・地図・解説 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=50 cd-vols= no-issue=1 article-no= start-page=03000605211070492 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220107 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Severe pediatric asthma with a poor response to omalizumab: a report of three cases and three-dimensional bronchial wall analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Omalizumab is used for the treatment of persistent severe allergic asthma in adults and children. However, some patients remain symptomatic even after omalizumab treatment. In bronchial asthma, chronic inflammation of the bronchial wall causes thickening of the airway wall, resulting from irreversible airway remodeling. Progression of airway remodeling causes airflow obstruction, leading to treatment resistance. We report three Japanese children with severe asthma who had a poor response to omalizumab treatment. They had a long period of inadequate management of asthma before initiating omalizumab. Even after omalizumab treatment, their symptoms persisted, and the parameters of spirometry tests did not improve. We hypothesized that omalizumab was less effective in these patients because airway wall remodeling had already progressed. We retrospectively evaluated the bronchial wall thickness using a three-dimensional bronchial wall analysis with chest computed tomography. The bronchial wall thickness was increased in these cases compared with six responders. Progressed airway wall thickness caused by airway remodeling may be associated with a poor response to omalizumab in children with severe asthma. en-copyright= kn-copyright= en-aut-name=TsugeMitsuru en-aut-sei=Tsuge en-aut-mei=Mitsuru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaMasanori en-aut-sei=Ikeda en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KondoYoichi en-aut-sei=Kondo en-aut-mei=Yoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TsukaharaHirokazu en-aut-sei=Tsukahara en-aut-mei=Hirokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Pediatrics, Matsuyama Red Cross Hospital kn-affil= affil-num=4 en-affil=Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Bronchial asthma kn-keyword=Bronchial asthma en-keyword=omalizumab kn-keyword=omalizumab en-keyword=bronchial wall thickness kn-keyword=bronchial wall thickness en-keyword=child kn-keyword=child en-keyword=computed tomography kn-keyword=computed tomography en-keyword=airway kn-keyword=airway END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=11 article-no= start-page=1067 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20211119 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Current Insights into Atopic March en-subtitle= kn-subtitle= en-abstract= kn-abstract=The incidence of allergic diseases is increasing, and research on their epidemiology, pathophysiology, and the prevention of onset is urgently needed. The onset of allergic disease begins in infancy with atopic dermatitis and food allergy and develops into allergic asthma and allergic rhinitis in childhood; the process is defined as "atopic march ". Atopic march is caused by multiple immunological pathways, including allergen exposure, environmental pollutants, skin barrier dysfunction, type 2 inflammation, and oxidative stress, which promote the progression of atopic march. Using recent evidence, herein, we explain the involvement of allergic inflammatory conditions and oxidative stress in the process of atopic march, its epidemiology, and methods for prevention of onset. en-copyright= kn-copyright= en-aut-name=TsugeMitsuru en-aut-sei=Tsuge en-aut-mei=Mitsuru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaMasanori en-aut-sei=Ikeda en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsumotoNaomi en-aut-sei=Matsumoto en-aut-mei=Naomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TsukaharaHirokazu en-aut-sei=Tsukahara en-aut-mei=Hirokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Pediatric Acute Diseases, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Pediatrics, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Epidemiology, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Epidemiology, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Pediatrics, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=atopic march kn-keyword=atopic march en-keyword=atopic dermatitis kn-keyword=atopic dermatitis en-keyword=food allergy kn-keyword=food allergy en-keyword=allergic asthma kn-keyword=allergic asthma en-keyword=allergic rhinitis kn-keyword=allergic rhinitis en-keyword=skin barrier dysfunction kn-keyword=skin barrier dysfunction en-keyword=alarmin kn-keyword=alarmin en-keyword=group 2 innate lymphoid cells kn-keyword=group 2 innate lymphoid cells en-keyword=type 2 inflammation kn-keyword=type 2 inflammation en-keyword=oxidative stress kn-keyword=oxidative stress en-keyword=specific biomarker kn-keyword=specific biomarker en-keyword=epidemiology kn-keyword=epidemiology en-keyword=phenotype kn-keyword=phenotype en-keyword=early intervention kn-keyword=early intervention en-keyword=emollient kn-keyword=emollient END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=310 end-page=334 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=2021 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=付録　大寄合之覚書　寛文六年 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=232 end-page=309 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=2021 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=御留帳評定書　貞享元年・二年 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=145 end-page=231 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=2021 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=御留帳評定書　天和三年 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=77 end-page=144 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=2021 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=御留帳評定書　天和二年 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=1 end-page=76 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=2021 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=御留帳評定書　天和元年 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=原生生物タイヨウチュウRaphidocystis contractilisの急速な軸足収縮機構に関する研究 kn-title=Studies on mechanisms of rapid axopodial contraction in the centrohelid Raphidocystis contractilis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaRisa en-aut-sei=Ikeda en-aut-mei=Risa kn-aut-name=池田理佐 kn-aut-sei=池田 kn-aut-mei=理佐 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=EBV陽性粘膜皮膚潰瘍の日本人患者34名に関する臨床病理学的解析 kn-title= Clinicopathological analysis of 34 Japanese patients with EBV-positive mucocutaneous ulcer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaTomoka en-aut-sei=Ikeda en-aut-mei=Tomoka kn-aut-name=池田知佳 kn-aut-sei=池田 kn-aut-mei=知佳 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=8 article-no= start-page=1438 end-page=1448 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200415 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Life-Course Monitoring of Endogenous Phytohormone Levels under Field Conditions Reveals Diversity of Physiological States among Barley Accessions en-subtitle= kn-subtitle= en-abstract= kn-abstract=Agronomically important traits often develop during the later stages of crop growth as consequences of various plant–environment interactions. Therefore, the temporal physiological states that change and accumulate during the crop’s life course can significantly affect the eventual phenotypic differences in agronomic traits among crop varieties. Thus, to improve productivity, it is important to elucidate the associations between temporal physiological responses during the growth of different crop varieties and their agronomic traits. However, data representing the dynamics and diversity of physiological states in plants grown under field conditions are sparse. In this study, we quantified the endogenous levels of five phytohormones — auxin, cytokinins (CKs), ABA, jasmonate and salicylic acid — in the leaves of eight diverse barley (Hordeum vulgare) accessions grown under field conditions sampled weekly over their life course to assess the ongoing fluctuations in hormone levels in the different accessions under field growth conditions. Notably, we observed enormous changes over time in the development-related plant hormones, such as auxin and CKs. Using 3′ RNA-seq-based transcriptome data from the same samples, we investigated the expression of barley genes orthologous to known hormone-related genes of Arabidopsis throughout the life course. These data illustrated the dynamics and diversity of the physiological states of these field-grown barley accessions. Together, our findings provide new insights into plant–environment interactions, highlighting that there is cultivar diversity in physiological responses during growth under field conditions. en-copyright= kn-copyright= en-aut-name=HirayamaTakashi en-aut-sei=Hirayama en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SaishoDaisuke en-aut-sei=Saisho en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsuuraTakakazu en-aut-sei=Matsuura en-aut-mei=Takakazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkadaSatoshi en-aut-sei=Okada en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakahagiKotaro en-aut-sei=Takahagi en-aut-mei=Kotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KanataniAsaka en-aut-sei=Kanatani en-aut-mei=Asaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ItoJun en-aut-sei=Ito en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TsujiHiroyuki en-aut-sei=Tsuji en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=IkedaYoko en-aut-sei=Ikeda en-aut-mei=Yoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MochidaKeiichi en-aut-sei=Mochida en-aut-mei=Keiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=2 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=3 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=4 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=5 en-affil=RIKEN Center for Sustainable Resource Science kn-affil= affil-num=6 en-affil=RIKEN Center for Sustainable Resource Science kn-affil= affil-num=7 en-affil=Kihara Institute for Biological Research, Yokohama City University kn-affil= affil-num=8 en-affil=Kihara Institute for Biological Research, Yokohama City University kn-affil= affil-num=9 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=10 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= en-keyword=transcriptome kn-keyword=transcriptome en-keyword=barley kn-keyword=barley en-keyword=filed conditions kn-keyword=filed conditions en-keyword=hormone profiling kn-keyword=hormone profiling en-keyword=life-course monitoring kn-keyword=life-course monitoring END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=10 article-no= start-page=100463 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202010 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Evaluation of oral immunotherapy efficacy and safety by maintenance dose dependency: A multicenter randomized study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background
Generally, oral immunotherapy (OIT) aims for daily administration. Recently, the efficacy of treatment with OIT at a low dose has been reported. However, the optimal dose and the evaluation of dose-dependent OIT outcome have not been described.
Methods
A multicenter, parallel, open-labeled, prospective, non-placebo controlled, randomized study enrolled 101 Japanese patients for treatment with OIT. We hypothesized that target dose OIT would induce short-term unresponsiveness (StU) earlier than reduced dose OIT. StU was defined as no response to 6200 mg whole egg, 3400 mg milk, and 2600 mg wheat protein, as evaluated by oral food challenge after 2-week ingestion cessation. To compare the two doses of OIT efficacy, the maximum ingestion doses during the maintenance phase of OIT were divided into 100%-dose or 25%-dose groups against their target StU dose, respectively. A total of 51 patients were assigned to the 100%-dose group [hen's egg (HE) = 26, cow's milk (CM) = 13, wheat = 12] and 50 to the 25%-dose group (HE = 25, CM = 13, wheat = 12). Primary outcome was established by comparing StU at 1 year. Secondary outcome was StU at 2 years and established by comparing allergic symptoms and immunological changes.
Results
The year 1 StU rates (%) for the 100%- and 25%-dose groups were 26.9 vs. 20.0 (HE), 7.7 vs. 15.4 (CM), and 50.0 vs. 16.7 (wheat), respectively. The year 2 StU rates were 30.8 vs. 36.0 (HE), 7.7 vs. 23.1 (CM), and 58.3 vs. 58.3 (wheat), respectively. There were no statistically significant differences in StU between years 1 and 2. The total allergic symptom rate in the 25%-dose group was lower than that in the 100%-dose group for egg, milk, and wheat. Antigen-specific IgE levels for egg-white, milk, and wheat decreased at 12 months.
Conclusions
Reduced maintenance dose of egg OIT showed similar therapeutic efficacy to the target dose. However, we were not able to clearly demonstrate the efficacy, particularly for milk and wheat. Reducing the maintenance dose for eggs, milk, and wheat may effectively lower the symptoms associated with their consumption compared to the target OIT dose. Furthermore, aggressive reduction of the maintenance dose might be important for milk and wheat, compared to the 25%-dose OIT. en-copyright= kn-copyright= en-aut-name=OguraKiyotake en-aut-sei=Ogura en-aut-mei=Kiyotake kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YanagidaNoriyuki en-aut-sei=Yanagida en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SatoSakura en-aut-sei=Sato en-aut-mei=Sakura kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ImaiTakanori en-aut-sei=Imai en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ItoKomei en-aut-sei=Ito en-aut-mei=Komei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KandoNaoyuki en-aut-sei=Kando en-aut-mei=Naoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IkedaMasanori en-aut-sei=Ikeda en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ShibataRumiko en-aut-sei=Shibata en-aut-mei=Rumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MurakamiYoko en-aut-sei=Murakami en-aut-mei=Yoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=FujisawaTakao en-aut-sei=Fujisawa en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=NagaoMizuho en-aut-sei=Nagao en-aut-mei=Mizuho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=KawamotoNorio en-aut-sei=Kawamoto en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KondoNaomi en-aut-sei=Kondo en-aut-mei=Naomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=UrisuAtsuo en-aut-sei=Urisu en-aut-mei=Atsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=TsugeIkuya en-aut-sei=Tsuge en-aut-mei=Ikuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=KondoYasuto en-aut-sei=Kondo en-aut-mei=Yasuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=SugaiKazuko en-aut-sei=Sugai en-aut-mei=Kazuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=UchidaOsamu en-aut-sei=Uchida en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=UrashimaMitsuyoshi en-aut-sei=Urashima en-aut-mei=Mitsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=TaniguchiMasami en-aut-sei=Taniguchi en-aut-mei=Masami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=EbisawaMotohiro en-aut-sei=Ebisawa en-aut-mei=Motohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= affil-num=1 en-affil=Department of Pediatrics, National Hospital Organization, Sagamihara National Hospital kn-affil= affil-num=2 en-affil=Department of Pediatrics, National Hospital Organization, Sagamihara National Hospital kn-affil= affil-num=3 en-affil=Course of Allergy and Clinical Immunology, Juntendo University Graduate School of Medicine kn-affil= affil-num=4 en-affil=Department of Pediatrics, Showa University School of Medicine kn-affil= affil-num=5 en-affil=Department of Allergy, Aichi Children's Health and Medical Center kn-affil= affil-num=6 en-affil=Department of Allergy, Aichi Children's Health and Medical Center kn-affil= affil-num=7 en-affil=Department of Pediatric Acute Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Pediatrics, National Hospital Organization, Fukuoka National Hospital kn-affil= affil-num=9 en-affil=Department of Pediatrics, National Hospital Organization, Fukuoka National Hospital kn-affil= affil-num=10 en-affil=Institute for Clinical Research, National Hospital Organization, Mie National Hospital kn-affil= affil-num=11 en-affil=Institute for Clinical Research, National Hospital Organization, Mie National Hospital kn-affil= affil-num=12 en-affil=Department of Pediatrics, Graduate School of Medicine, Gifu University kn-affil= affil-num=13 en-affil=Department of Pediatrics, Graduate School of Medicine, Gifu University kn-affil= affil-num=14 en-affil=Department of Pediatrics, Fujita Health University, The Second Teaching Hospital kn-affil= affil-num=15 en-affil=Department of Pediatrics, Fujita Health University, The Second Teaching Hospital kn-affil= affil-num=16 en-affil=Department of Pediatrics, Fujita Health University, The Second Teaching Hospital kn-affil= affil-num=17 en-affil=Department of Pediatrics, National Hospital Organization, Yokohama Medical Center kn-affil= affil-num=18 en-affil=Department of Pediatrics, National Hospital Organization, Yokohama Medical Center kn-affil= affil-num=19 en-affil=Division of Molecular Epidemiology, The Jikei University School of Medicine kn-affil= affil-num=20 en-affil=Course of Allergy and Clinical Immunology, Juntendo University Graduate School of Medicine kn-affil= affil-num=21 en-affil=Course of Allergy and Clinical Immunology, Juntendo University Graduate School of Medicine kn-affil= en-keyword=Food hypersensitivity kn-keyword=Food hypersensitivity en-keyword=Immunotherapy kn-keyword=Immunotherapy en-keyword=Dose-response relationship kn-keyword=Dose-response relationship en-keyword=Desensitization kn-keyword=Desensitization END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=3 article-no= start-page=356 end-page=369 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Japanese guidelines for atopic dermatitis 2020. en-subtitle= kn-subtitle= en-abstract= kn-abstract=Atopic dermatitis (AD) is a disease characterized by relapsing eczema with pruritus as a primary lesion, which is frequently encountered in clinical practice. Skin barrier dysfunction leads to enhanced skin irritability to non-specific stimuli and epicutaneous sensitization. In the lesion site, a further inflammation-related reduction in skin barrier function, enhanced irritability and scratching-related stimuli deteriorate eczema, leading to vicious cycle of inflammation. The current strategies to treat AD in Japan from the perspective of evidence-based medicine consist of three primary measures: (i) the use of topical corticosteroids and tacrolimus ointment as the main treatment for the inflammation; (ii) topical application of emollients to treat the cutaneous barrier dysfunction; and (iii) avoidance of apparent exacerbating factors, psychological counseling and advice about daily life. The guidelines present recommendations to review clinical research articles, evaluate the balance between the advantages and disadvantages of medical activities, and optimize medical activity-related patient outcomes with respect to several important points requiring decision-making in clinical practice. en-copyright= kn-copyright= en-aut-name=KatohNorito en-aut-sei=Katoh en-aut-mei=Norito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhyaYukihiro en-aut-sei=Ohya en-aut-mei=Yukihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IkedaMasanori en-aut-sei=Ikeda en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=EbiharaTamotsu en-aut-sei=Ebihara en-aut-mei=Tamotsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KatayamaIchiro en-aut-sei=Katayama en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SaekiHidehisa en-aut-sei=Saeki en-aut-mei=Hidehisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShimojoNaoki en-aut-sei=Shimojo en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TanakaAkio en-aut-sei=Tanaka en-aut-mei=Akio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NakaharaTakeshi en-aut-sei=Nakahara en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NagaoMizuho en-aut-sei=Nagao en-aut-mei=Mizuho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=HideMichihiro en-aut-sei=Hide en-aut-mei=Michihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=FujitaYuji en-aut-sei=Fujita en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=FujisawaTakao en-aut-sei=Fujisawa en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=FutamuraMasaki en-aut-sei=Futamura en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=MasudaKoji en-aut-sei=Masuda en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=MurotaHiroyuki en-aut-sei=Murota en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=Yamamoto-HanadaKiwako en-aut-sei=Yamamoto-Hanada en-aut-mei=Kiwako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= affil-num=1 en-affil=Department of Dermatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science kn-affil= affil-num=2 en-affil=Allergy Center, National Center for Child Health and Development kn-affil= affil-num=3 en-affil=Department of Pediatric Acute Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Dermatology, Keio University School of Medicine kn-affil= affil-num=5 en-affil=Department of Dermatology, Graduate School of Medicine, Osaka University kn-affil= affil-num=6 en-affil=Department of Dermatology, Graduate School of Medicine, Nihon Medical School kn-affil= affil-num=7 en-affil=Department of Pediatrics, Graduate School of Medicine, Chiba University kn-affil= affil-num=8 en-affil=Department of Dermatology, Hiroshima University Graduate School of Biomedical Sciences kn-affil= affil-num=9 en-affil=Division of Skin Surface Sensing, Department of Dermatology, Graduate School of Medical Sciences, Kyushu University kn-affil= affil-num=10 en-affil=Division of Clinical Research, National Hospital Organization Mie National Hospital kn-affil= affil-num=11 en-affil=Department of Dermatology, Hiroshima University Graduate School of Biomedical Sciences kn-affil= affil-num=12 en-affil=Department of Pediatrics, Graduate School of Medicine, Chiba University kn-affil= affil-num=13 en-affil=Division of Allergy, National Hospital Organization Mie National Hospital kn-affil= affil-num=14 en-affil=Division of Pediatrics, National Hospital Organization Nagoya Medical Center kn-affil= affil-num=15 en-affil=Department of Dermatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science kn-affil= affil-num=16 en-affil=Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences kn-affil= affil-num=17 en-affil=Allergy Center, National Center for Child Health and Development kn-affil= en-keyword=Atopic dermatitis kn-keyword=Atopic dermatitis en-keyword=Clinical practice guidelines kn-keyword=Clinical practice guidelines en-keyword=Eczema kn-keyword=Eczema en-keyword=Evidence-based medicine kn-keyword=Evidence-based medicine en-keyword=Treatment kn-keyword=Treatment END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=3 article-no= start-page=470 end-page=480 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20191113 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Regulation of the Poly(A) Status of Mitochondrial mRNA by Poly(A)-Specific Ribonuclease Is Conserved among Land Plants en-subtitle= kn-subtitle= en-abstract= kn-abstract=Regulation of the stability and the quality of mitochondrial RNA is essential for the maintenance of mitochondrial and cellular functions in eukaryotes. We have previously reported that the eukaryotic poly(A)-specific ribonuclease (PARN) and the prokaryotic poly(A) polymerase encoded by AHG2 and AGS1, respectively, coordinately regulate the poly(A) status and the stability of mitochondrial mRNA in Arabidopsis. Mitochondrial function of PARN has not been reported in any other eukaryotes. To know how much this PARN-based mitochondrial mRNA regulation is conserved among plants, we studied the AHG2 and AGS1 counterparts of the liverwort, Marchantia polymorpha, a member of basal land plant lineage. We found that M. polymorpha has one ortholog each for AHG2 and AGS1, named MpAHG2 and MpAGS1, respectively. Their Citrine-fused proteins were detected in mitochondria of the liverwort. Molecular genetic analysis showed that MpAHG2 is essential and functionally interacts with MpAGS1 as observed in Arabidopsis. A recombinant MpAHG2 protein had a deadenylase activity in vitro. Overexpression of MpAGS1 and the reduced expression of MpAHG2 caused an accumulation of polyadenylated Mpcox1 mRNA. Furthermore, MpAHG2 suppressed Arabidopsis ahg2-1 mutant phenotype. These results suggest that the PARN-based mitochondrial mRNA regulatory system is conserved in land plants. en-copyright= kn-copyright= en-aut-name=KanazawaMai en-aut-sei=Kanazawa en-aut-mei=Mai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaYoko en-aut-sei=Ikeda en-aut-mei=Yoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NishihamaRyuichi en-aut-sei=Nishihama en-aut-mei=Ryuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamaokaShohei en-aut-sei=Yamaoka en-aut-mei=Shohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=LeeNam-Hee en-aut-sei=Lee en-aut-mei=Nam-Hee kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamatoKatsuyuki T en-aut-sei=Yamato en-aut-mei=Katsuyuki T kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KohchiTakayuk en-aut-sei=Kohchi en-aut-mei=Takayuk kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HirayamaTakashi en-aut-sei=Hirayama en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Division of Science for Bioresources, Graduate School of Environment and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Division of Science for Bioresources, Graduate School of Environment and Life Science, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Biostudies, Kyoto University kn-affil= affil-num=4 en-affil=Graduate School of Biostudies, Kyoto University kn-affil= affil-num=5 en-affil=Department of Life Sciences, Faculty of Science and Engineering, Sorbonne University kn-affil= affil-num=6 en-affil=Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Kindai University kn-affil= affil-num=7 en-affil=Graduate School of Biostudies, Kyoto University kn-affil= affil-num=8 en-affil=Division of Science for Bioresources, Graduate School of Environment and Life Science, Okayama University kn-affil= en-keyword=Arabidopsis kn-keyword=Arabidopsis en-keyword=Marchantia polymorpha kn-keyword=Marchantia polymorpha en-keyword=Mitochondria kn-keyword=Mitochondria en-keyword= Poly(A) polymerase kn-keyword= Poly(A) polymerase en-keyword=Poly(A) regulation kn-keyword=Poly(A) regulation en-keyword= Poly(A)-specific ribonuclease kn-keyword= Poly(A)-specific ribonuclease END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=2380179 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Serum Procalcitonin Levels in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion en-subtitle= kn-subtitle= en-abstract= kn-abstract=Procalcitonin (PCT) is used as a biomarker in severe infections. Here, we retrospectively investigated levels of serum PCT, C-reactive protein (CRP), and inflammatory cytokines (IL-6, TNF-alpha, and IFN-gamma) in the second phase of patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). Nine AESD pediatric patients (4 men, 5 women; AESD group) admitted to Okayama University Hospital from 2010 to 2016 were compared with 10 control patients with febrile seizures (FS) (3 men, 7 women; FS group). Mean PCT concentrations (ng/mL) in the AESD and FS groups were significantly different, at 9.8 +/- 6.7 and 0.8 +/- 0.9, respectively (p = 0 0006). CRP (mg/dL) were 0.79 +/- 0.89 and 1.4 +/- 1.0 (p = 0 94), respectively; IL-6 (pg/mL) were 449.7 +/- 705.0 and 118.3 +/- 145.4 (p = 0 20), respectively; TNF-alpha (pg/mL) were 18.6 +/- 12.5 and 16.6 +/- 6.0 (p = 0 67), respectively; and IFN-gamma (pg/mL) were 79.6 +/- 158.5 and 41.9 +/- 63.7 (p = 0 56), respectively. Ratios of PCT to CRP were 27.5 +/- 34.2 and 3.2 +/- 6.8 (p < 0 0001), respectively. The sensitivity and specificity in the diagnosis of AESD using a cutoff of PCT/CRP ratio of 1.0 were 79% and 100%, respectively. These results suggest that PCT and the PCT/CRP ratio are useful in auxiliary diagnosis of the second stage of AESD, and in AESD, PCT is likely to increase through a different mechanism. en-copyright= kn-copyright= en-aut-name=FujiiYosuke en-aut-sei=Fujii en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YashiroMasato en-aut-sei=Yashiro en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamadaMutsuko en-aut-sei=Yamada en-aut-mei=Mutsuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KikkawaTomonobu en-aut-sei=Kikkawa en-aut-mei=Tomonobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NosakaNobuyuki en-aut-sei=Nosaka en-aut-mei=Nobuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SaitoYukie en-aut-sei=Saito en-aut-mei=Yukie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TsukaharaKohei en-aut-sei=Tsukahara en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IkedaMasanori en-aut-sei=Ikeda en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MorishimaTsuneo en-aut-sei=Morishima en-aut-mei=Tsuneo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TsukaharaHirokazu en-aut-sei=Tsukahara en-aut-mei=Hirokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Pediatric Acute Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry and kn-affil= affil-num=8 en-affil=Department of Pediatric Acute Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=同所性肝移植を受けた患者におけるＢ型肝炎ウイルス表面抗原に対するワクチン成功の予測因子 kn-title=Predictive Factors for Successful Vaccination Against Hepatitis B Surface Antigen in Patients Who Have Undergone Orthotopic Liver Transplantation en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaAiri en-aut-sei=Ikeda en-aut-mei=Airi kn-aut-name=池田愛璃 kn-aut-sei=池田 kn-aut-mei=愛璃 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=21 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cytoskeletal elements in an acoelomorph worm, Praesagittifera naikaiensis kn-title=無腸動物Praesagittifera naikaiensis における細胞骨格要素 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Acoel flatworms can move in a variety of ways such as muscular and ciliary movements via cytoskeletal elements and their neural regulations. However, those locomotive mechanisms have not yet been fully elucidated. In this study, we examined the distribution of cytoskeletal elements including filamentous actin (F-actin) and tubulin, and the neuroanatomical organization in an acoelomorph worm, Praesagittifera naikaiensis (P. naikaiensis). Video microscopy revealed the elongation/contraction and the bending/rotation processes, and the ciliary gliding movement of P. naikaiensis. Histochemical and morphological analysis demonstrated that F-actin networks of inner longitudinal and outer circular muscle fibers were positioned along the entire surface of the body, and that the average distance between the circular muscle fibers in the contracted organism was decreased in the anterior region compared with that in the elongated organism. Electron microscopy showed dense bodies on the muscle cells of P. naikaiensis, which indicates that those muscle cells have the appearance of vertebrate smooth muscle cells. Immunohistochemical analysis revealed that -tubulin-positive signals on the ciliary microtubules had close contact with the F-actin network, and that neurite bundles labelled with anti dSap47 antibody as a neuronal marker run along the anterior-posterior body axis. These results indicate that the well-organized cytoskeletal elements and their neural control systems are preserved in P. naikaiensis, and that their mechanisms involved in those regulation systems are similar to those vertebrate systems. Further studies are needed to clarify the physiological mechanisms underlying the muscular and ciliary movements in P. naikaiensis. en-copyright= kn-copyright= en-aut-name=IkedaRisa en-aut-sei=Ikeda en-aut-mei=Risa kn-aut-name=池田理佐 kn-aut-sei=池田 kn-aut-mei=理佐 aut-affil-num=1 ORCID= en-aut-name=FujiwaraChiho en-aut-sei=Fujiwara en-aut-mei=Chiho kn-aut-name=藤原稚穂 kn-aut-sei=藤原 kn-aut-mei=稚穂 aut-affil-num=2 ORCID= en-aut-name=HamadaMayuko en-aut-sei=Hamada en-aut-mei=Mayuko kn-aut-name=濱田麻友子 kn-aut-sei=濱田 kn-aut-mei=麻友子 aut-affil-num=3 ORCID= en-aut-name=SakamotoTatsuya en-aut-sei=Sakamoto en-aut-mei=Tatsuya kn-aut-name=坂本竜哉 kn-aut-sei=坂本 kn-aut-mei=竜哉 aut-affil-num=4 ORCID= en-aut-name=SaitoNoboru en-aut-sei=Saito en-aut-mei=Noboru kn-aut-name=齋藤昇 kn-aut-sei=齋藤 kn-aut-mei=昇 aut-affil-num=5 ORCID= en-aut-name=AndoMotonori en-aut-sei=Ando en-aut-mei=Motonori kn-aut-name=安藤元紀 kn-aut-sei=安藤 kn-aut-mei=元紀 aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科 affil-num=2 en-affil=Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科 affil-num=3 en-affil=Ushimado Marine Institute, Faculty of Science, Okayama University kn-affil=岡山大学・理学部附属臨海実験所 affil-num=4 en-affil=Ushimado Marine Institute, Faculty of Science, Okayama University kn-affil=岡山大学・理学部附属臨海実験所 affil-num=5 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil=岡山大学大学院環境生命科学研究科 affil-num=6 en-affil=Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=機能性ペプチドKP24が顎下腺組織成長に及ぼす影響の検討 kn-title=Functional peptide KP24 enhances submandibular gland tissue growth in vitro en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaAtsushi en-aut-sei=Ikeda en-aut-mei=Atsushi kn-aut-name=池田篤司 kn-aut-sei=池田 kn-aut-mei=篤司 aut-affil-num=1 ORCID= affil-num=1 en-affil=Okayama University kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=135 end-page=150 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20171230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Meaning of their Existence in Multicultural Business Environments and their Workplace for Former Taiwanese Students kn-title=台湾人元留学生の職場における自己の存在意義と職場の意味 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　本研究の目的は、近年増加傾向にある日本留学を経て日本企業に就職した台湾人元留学生を対象とし、職場における自己の存在意義と自分の職場の意味をどのように捉えているかを質的な分析を通して解明することである。就労開始後10 年以内の台湾人元大学院留学生9 名を対象に半構造化インタビューを実施し、KJ 法を援用し分析を行った結果、自己の存在意義計29 件、職場の意味計31 件が抽出された。この結果から、本調査対象者は、多文化就労場面における元留学生である自己の存在意義を見出せるケースと見出せないケースが拮抗していること、また、自分の職場を概ね肯定的に捉えているものの、同時に二律背反的な見方が一個人の中に併存することが示された。 en-copyright= kn-copyright= en-aut-name=MoriyaTomomi en-aut-sei=Moriya en-aut-mei=Tomomi kn-aut-name=守谷智美 kn-aut-sei=守谷 kn-aut-mei=智美 aut-affil-num=1 ORCID= en-aut-name=WadaKaoruko en-aut-sei=Wada en-aut-mei=Kaoruko kn-aut-name=和田薫子 kn-aut-sei=和田 kn-aut-mei=薫子 aut-affil-num=2 ORCID= en-aut-name=IkedaSeiko en-aut-sei=Ikeda en-aut-mei=Seiko kn-aut-name=池田聖子 kn-aut-sei=池田 kn-aut-mei=聖子 aut-affil-num=3 ORCID= en-aut-name=KagamiTomiyo en-aut-sei=Kagami en-aut-mei=Tomiyo kn-aut-name=加賀美常美代 kn-aut-sei=加賀美 kn-aut-mei=常美代 aut-affil-num=4 ORCID= affil-num=1 en-affil=Institute for Education and Student Services, Okayama University kn-affil=岡山大学全学教育・ 学生支援機構 affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= affil-num=4 en-affil= kn-affil= en-keyword=台湾人 kn-keyword=台湾人 en-keyword=元留学生 kn-keyword=元留学生 en-keyword=職場 kn-keyword=職場 en-keyword=存在意義 kn-keyword=存在意義 en-keyword=多文化就労 kn-keyword=多文化就労 END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=3 article-no= start-page=167 end-page=169 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20171201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 2016 Incentive Award of the Okayama Medical Association in Neuroscience (2016 Niimi Prize) kn-title=平成28年度岡山医学会賞 脳神経研究奨励賞（新見賞） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaChikako en-aut-sei=Ikeda en-aut-mei=Chikako kn-aut-name=池田智香子 kn-aut-sei=池田 kn-aut-mei=智香子 aut-affil-num=1 ORCID= affil-num=1 en-affil= Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　精神神経病態学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170929 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ポリエチレングリコールと陽イオン交換クロマトグラフィを用いた血漿中apoE-rich HDLの迅速で精密な測定法の確立：apoE-rich HDL測定の臨床的有用性に関するパイロット研究 kn-title=A rapid and precise method for measuring plasma apoE-rich HDL using polyethylene glycol and cation-exchange chromatography: a pilot study on the clinical significance of apoE-rich HDL measurements. en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaToru en-aut-sei=Ikeda en-aut-mei=Toru kn-aut-name=池田亮 kn-aut-sei=池田 kn-aut-mei=亮 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil=岡山大学大学院保健学研究科 END start-ver=1.4 cd-journal=joma no-vol=165 cd-vols= no-issue= article-no= start-page=43 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170728 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An essay on a relation of the waterwheel and the water bowl in the Okayama Korakuen Garden kn-title=岡山後楽園の水車と延養亭前手水鉢の関係試論 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　日本三名園の一つに数えられている岡山後楽園には水車が回っている。他に水車のある日本庭園があるかどうか，あまり例を聞かない。何の為に水車があるのか？　筆者はその水車に歴史的，心理的な光でなく，科学的な光を当ててみようとした。水車・底樋・手水鉢の三つの部品を組み合わせた日本初の新しい暑気払いの為の装置ではなかったのか，との発見をしたように思うので，ここで議論の材料として提出したい。詳細な内容については別途機会を得て提出する。 en-copyright= kn-copyright= en-aut-name=SahashiKen en-aut-sei=Sahashi en-aut-mei=Ken kn-aut-name=佐橋謙 kn-aut-sei=佐橋 kn-aut-mei=謙 aut-affil-num=1 ORCID= affil-num=1 en-affil=Okayama University Graduate School of Education kn-affil=岡山大学大学院教育学研究科 en-keyword=岡山後楽園 kn-keyword=岡山後楽園 en-keyword=池田家文庫 kn-keyword=池田家文庫 en-keyword=水車 kn-keyword=水車 en-keyword=底樋 kn-keyword=底樋 en-keyword=手水鉢 kn-keyword=手水鉢 en-keyword=U字管 kn-keyword=U字管 END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue=5 article-no= start-page=e67 end-page=e69 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201305 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A novel familial prion disease causing pan-autonomic-sensory neuropathy and cognitive impairment en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MatsuzonoKosuke en-aut-sei=Matsuzono en-aut-mei=Kosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaYoshio en-aut-sei=Ikeda en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=LiuWentao en-aut-sei=Liu en-aut-mei=Wentao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KurataTomoko en-aut-sei=Kurata en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=DeguchiShoko en-aut-sei=Deguchi en-aut-mei=Shoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=DeguchiKentaro en-aut-sei=Deguchi en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil=Department of Neurology, Okayama University Graduate School of Medicine and Dentistry kn-affil= affil-num=3 en-affil= kn-affil= affil-num=4 en-affil=Department of Neurology, Okayama University Graduate School of Medicine and Dentistry kn-affil= affil-num=5 en-affil= kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama University Graduate School of Medicine and Dentistry kn-affil= affil-num=7 en-affil=Department of Neurology, Okayama University Graduate School of Medicine and Dentistry kn-affil= en-keyword=Prion disease kn-keyword=Prion disease en-keyword=Novelgene mutation kn-keyword=Novelgene mutation en-keyword=2bp deletion in codon 178 kn-keyword=2bp deletion in codon 178 en-keyword=stopcodon at codon 195 kn-keyword=stopcodon at codon 195 en-keyword=Sensoryneuropathy kn-keyword=Sensoryneuropathy en-keyword=HSAN kn-keyword=HSAN en-keyword=Pan-autonomicfailure kn-keyword=Pan-autonomicfailure en-keyword=Familial case kn-keyword=Familial case END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=26 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Structure and function of tegmentum vasculosum in avian cochlea kn-title=鳥類内耳tegmentum vasculosum の構造と機能 en-subtitle= kn-subtitle= en-abstract= kn-abstract= In spite of the importance of endocochlear DC potential (EP) and the K+-rich endolymph for the avian cochlea, the structure and function of the tegmentum vasculosum (TV) has not yet been fully elucidated, compared with those of the stria vascularis in the mammalian cochlea. In this study, we examined structural analysis of the epithelial cells, gene expressions of Na+-K+-ATPase (Atp1A1) and Kir4.1 (Kcnj10), and protein localizations of Na+-K+-ATPase and Kir4.1, in the TV. Tight junctional structures were observed between epithelial dark cells and light cells in the TV. Both Atp1a1 and Kcnj10 genes were detected in the TV. In addition, immunopositive signals for both Na+-K+-ATPase and Kir4.1 were recognized in the TV. These results indicate that Na+-K+-ATPase and Kir4.1 play roles in maintaining the EP and high K+ concentration of the endolymph. Further studies are needed to clarify the physiological functions of the TV. This is the first report which demonstrates that gene and protein expression data contribute to the avian inner ear homeostasis. en-copyright= kn-copyright= en-aut-name=IkedaRisa en-aut-sei=Ikeda en-aut-mei=Risa kn-aut-name=池田理佐 kn-aut-sei=池田 kn-aut-mei=理佐 aut-affil-num=1 ORCID= en-aut-name=OtonoTsuyoshi en-aut-sei=Otono en-aut-mei=Tsuyoshi kn-aut-name=乙野剛史 kn-aut-sei=乙野 kn-aut-mei=剛史 aut-affil-num=2 ORCID= en-aut-name=IkedaNaoya en-aut-sei=Ikeda en-aut-mei=Naoya kn-aut-name=池田直矢 kn-aut-sei=池田 kn-aut-mei=直矢 aut-affil-num=3 ORCID= en-aut-name=SaitoNoboru en-aut-sei=Saito en-aut-mei=Noboru kn-aut-name=齋藤昇 kn-aut-sei=齋藤 kn-aut-mei=昇 aut-affil-num=4 ORCID= en-aut-name=AndoMotonori en-aut-sei=Ando en-aut-mei=Motonori kn-aut-name=安藤元紀 kn-aut-sei=安藤 kn-aut-mei=元紀 aut-affil-num=5 ORCID= affil-num=1 en-affil=Laboratory of Cell Physiology, Department of Science Education, Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科・理科教育講座・細胞生理学研究室 affil-num=2 en-affil=Laboratory of Cell Physiology, Department of Science Education, Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科・理科教育講座・細胞生理学研究室 affil-num=3 en-affil=Laboratory of Cell Physiology, Department of Science Education, Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科・理科教育講座・細胞生理学研究室 affil-num=4 en-affil=Laboratory of Animal Physiology and Pharmacology, Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University kn-affil=岡山大学大学院環境生命科学研究科・動物機能開発学講座・動物生理学研究室 affil-num=5 en-affil=Laboratory of Cell Physiology, Department of Science Education, Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科・理科教育講座・細胞生理学研究室 END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=1 article-no= start-page=17 end-page=22 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Sexual function before and after a tension-free vaginal mesh procedure for pelvic organ prolapse kn-title=骨盤臓器脱に対するTVM 手術前後の性機能に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract= We prospectively assessed sexual function before and after a tension-free vaginal mesh ( TVM) procedure for pelvic organ prolapse ( POP) . From April 2007 to March 2009, a total of 42 patients, who reported having an active sex life preoperatively underwent TVM for POP. Female sexual function was evaluated with the self-reporting, multiple-domain Female Sexual Function Index (FSFI) . We administered the FSFI to all of the patients before and at 3, 6, and 12 months after surgery. The mean age at surgery was 61.3±7.1 years. Before the TVM surgery, the FSFI score was very low ( 12.5±9.0) . The total FSFI score was improved significantly at 12 months after surgery ( 17.4±7.7) . The Arousal, Lubrication and Orgasm domains were significantly improved at 12 months after surgery. POP appears to have a significant negative impact on female sexual function. Our findings indicate that TVM for POP improved sexual function in a group of Japanese women with POP. en-copyright= kn-copyright= en-aut-name=MatsumotoYuko en-aut-sei=Matsumoto en-aut-mei=Yuko kn-aut-name=松本裕子 kn-aut-sei=松本 kn-aut-mei=裕子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Urology, Okayama University Graduate School of Medicne, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 en-keyword=骨盤臓器脱 (pelvic organ prolapse) kn-keyword=骨盤臓器脱 (pelvic organ prolapse) en-keyword=TVM (tension-free vaginal mesh) kn-keyword=TVM (tension-free vaginal mesh) en-keyword=女性泌尿器科 (female urology) kn-keyword=女性泌尿器科 (female urology) en-keyword=性機能 (sexual function) kn-keyword=性機能 (sexual function) END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=29 end-page=37 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160725 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Development of a Scale to Assess Opener Skills in Friendships（ University Student Edition） kn-title=友人を開示者としたオープナー・スキル尺度（大学生版）の開発 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HoriuchiTakashi en-aut-sei=Horiuchi en-aut-mei=Takashi kn-aut-name=堀内孝 kn-aut-sei=堀内 kn-aut-mei=孝 aut-affil-num=1 ORCID= en-aut-name=YamasakiNaoko en-aut-sei=Yamasaki en-aut-mei=Naoko kn-aut-name=山﨑直子 kn-aut-sei=山﨑 kn-aut-mei=直子 aut-affil-num=2 ORCID= en-aut-name=IkedaKeiko en-aut-sei=Ikeda en-aut-mei=Keiko kn-aut-name=池田恵子 kn-aut-sei=池田 kn-aut-mei=恵子 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学文学部 affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue= article-no= start-page=(21) end-page=(35) dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20161125 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On Unknown Publishing Ordinances of Osaka in the Edo Period : Known from two documents; “The Proclamations of Many Years Ago” and “The Notebook of Osaka and Okayama Proclamations” kn-title=『せん年より御ふれふみ』『大坂岡山御触留』で補われる江戸時代大阪出版法令について ―附、岡山大学附属図書館池田家文庫蔵『宝暦三癸酉八月ヨリ大坂岡山御触留』 所収大阪触達番号一覧― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YamamotoHideki en-aut-sei=Yamamoto en-aut-mei=Hideki kn-aut-name=山本秀樹 kn-aut-sei=山本 kn-aut-mei=秀樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院社会文化科学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=皮質下諸核の神経細胞性及びアストロサイト性のタウ病理の出現と嗜銀顆粒病の進行との関連性 kn-title=The Relationship Between Development of Neuronal and Astrocytic Tau Pathologies in Subcortical Nuclei and Progression of Argyrophilic Grain Disease en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaChikako en-aut-sei=Ikeda en-aut-mei=Chikako kn-aut-name=池田智香子 kn-aut-sei=池田 kn-aut-mei=智香子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=3 article-no= start-page=201 end-page=205 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20161201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ectopic sebaceous glands in the esophagus that became evident over a three-year span kn-title=3 年間の内視鏡所見の変化を観察できた食道異所性皮脂腺の1 例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= A 43-year-old Japanese woman was diagnosed with ectopic sebaceous glands in the esophagus by esophagogastroduodenoscopy and biopsy. At the age of 46, typical ectopic sebaceous glands were recognized in the upper esophagus, whereas yellowish white granules were faintly observed in the lower esophagus. Esophagogastroduodenoscopy examinations were repeated when she was 47 and again at 50 years old, and the lesions in the lower esophagus had become more evident over the ensuing 3 years. Esophageal ectopic sebaceous glands are relatively infrequent, and there have been few case reports describing the progression of the endoscopic features. We also report the clinical and endoscopic features of the five similar cases with pathologically proven ectopic sebaceous glands in the esophagus. en-copyright= kn-copyright= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name=岩室雅也 kn-aut-sei=岩室 kn-aut-mei=雅也 aut-affil-num=1 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=2 ORCID= en-aut-name=HaradaKeita en-aut-sei=Harada en-aut-mei=Keita kn-aut-name=原田馨太 kn-aut-sei=原田 kn-aut-mei=馨太 aut-affil-num=3 ORCID= en-aut-name=KanzakiHiromitsu en-aut-sei=Kanzaki en-aut-mei=Hiromitsu kn-aut-name=神崎洋光 kn-aut-sei=神崎 kn-aut-mei=洋光 aut-affil-num=4 ORCID= en-aut-name=HoriKeisuke en-aut-sei=Hori en-aut-mei=Keisuke kn-aut-name=堀圭介 kn-aut-sei=堀 kn-aut-mei=圭介 aut-affil-num=5 ORCID= en-aut-name=KitaMasahide en-aut-sei=Kita en-aut-mei=Masahide kn-aut-name=喜多雅英 kn-aut-sei=喜多 kn-aut-mei=雅英 aut-affil-num=6 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name=川野誠司 kn-aut-sei=川野 kn-aut-mei=誠司 aut-affil-num=7 ORCID= en-aut-name=KawaharaYoshiro en-aut-sei=Kawahara en-aut-mei=Yoshiro kn-aut-name=河原祥朗 kn-aut-sei=河原 kn-aut-mei=祥朗 aut-affil-num=8 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name=田中健大 kn-aut-sei=田中 kn-aut-mei=健大 aut-affil-num=9 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name=山本和秀 kn-aut-sei=山本 kn-aut-mei=和秀 aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=3 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=7 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=8 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=9 en-affil=Department of Pathology, Okayama University Hospital kn-affil=岡山大学病院　病理診断科 affil-num=10 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 en-keyword=食道異所性脂腺（ectopic sebaceous glands in the esophagus） kn-keyword=食道異所性脂腺（ectopic sebaceous glands in the esophagus） en-keyword=粘膜下腫瘍（submucosal tumor） kn-keyword=粘膜下腫瘍（submucosal tumor） en-keyword=食道黄色腫（esophageal xanthoma） kn-keyword=食道黄色腫（esophageal xanthoma） END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=癌関連遺伝子の同定のための計算手法の確立 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaMasashi en-aut-sei=Ikeda en-aut-mei=Masashi kn-aut-name=池田雅志 kn-aut-sei=池田 kn-aut-mei=雅志 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=1 article-no= start-page=1 end-page=12 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201602 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Entecavir Reduces Hepatocarcinogenesis in Chronic Hepatitis B Patients en-subtitle= kn-subtitle= en-abstract= kn-abstract=Chronic hepatitis B (CHB) leads to cirrhosis and hepatocellular carcinoma (HCC). With a cohort of 1,206 CHB patients who visited Okayama University Hospital and related hospitals in 2011 and 2012, we compared the incidence rates of HCC among the patients grouped by age, hepatitis B virus (HBV) DNA, hepatitis B e antigen (HBeAg), and treatment. HCCs were observed in 115 patients with the median observation period of 1,687 days. Among the HCC patients aged ≥ 35 years, HBV DNA ≥ 4 log copies/mL and positive HBeAg at diagnosis (n=184), the HCC incidence rate was 8.4% at 5 years in the entecavir (ETV)-treated patients, 21.8% in the lamivudine (LVD)-treated patients, and 26.4% among the patients not treated with drugs. The cumulative HCC incidence was significantly reduced in the ETV-treated patients compared to those treated with LVD or not treated (p=0.013). Among the patients aged ≥ 35 years with HBV DNA ≥ 4 log copies/mL and negative HBeAg (n=237), the cumulative HCC incidence was 14.6% in 5 years in ETV group and 13.9% among those not treated with a drug (p>0.05). Only small numbers of HCCs occurred in other patients. In CHB patients aged≥35 years with HBV DNA ≥4 log copies/mL and positive HBeAg, ETV treatment is recommended for the suppression of HCC development. en-copyright= kn-copyright= en-aut-name=YasunakaTetsuya en-aut-sei=Yasunaka en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WadaNozomu en-aut-sei=Wada en-aut-mei=Nozomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MorimotoYuki en-aut-sei=Morimoto en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujiokaShin-ichi en-aut-sei=Fujioka en-aut-mei=Shin-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ToshimoriJunichi en-aut-sei=Toshimori en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KobashiHaruhiko en-aut-sei=Kobashi en-aut-mei=Haruhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KariyamaKazuya en-aut-sei=Kariyama en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MorimotoYoichi en-aut-sei=Morimoto en-aut-mei=Yoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TakayamaHiroki en-aut-sei=Takayama en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=SenoTomonori en-aut-sei=Seno en-aut-mei=Tomonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=TakaguchiKoichi en-aut-sei=Takaguchi en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=MoriyaAkio en-aut-sei=Moriya en-aut-mei=Akio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=MiyatakeHirokazu en-aut-sei=Miyatake en-aut-mei=Hirokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=OkamotoRyoichi en-aut-sei=Okamoto en-aut-mei=Ryoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=YabushitaKazuhisa en-aut-sei=Yabushita en-aut-mei=Kazuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= affil-num=1 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Internal Medicine, Okayama Saiseikai General hospital affil-num=6 en-affil= kn-affil=Department of Gastroenterology, Okayama Red Cross Hospital affil-num=7 en-affil= kn-affil=Department of Gastroenterology, Okayama Red Cross Hospital affil-num=8 en-affil= kn-affil=Department of Liver Disease Center, Okayama City Hospital affil-num=9 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Kurashiki Central Hospital affil-num=10 en-affil= kn-affil=Department of Gastroenterology, Tsuyama Central Hospital affil-num=11 en-affil= kn-affil=Department of Hepatology, Kagawa Prefectural Central Hospital affil-num=12 en-affil= kn-affil=Department of Hepatology, Kagawa Prefectural Central Hospital affil-num=13 en-affil= kn-affil=Department of Medicine, Mitoyo Central Hospital affil-num=14 en-affil= kn-affil=Department of Internal Medicine, Hiroshima City Hospital affil-num=15 en-affil= kn-affil=Department of Internal Medicine, Hiroshima City Hospital affil-num=16 en-affil= kn-affil=Department of Internal Medicine, Fukuyama City Hospital affil-num=17 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=18 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=entecavir kn-keyword=entecavir en-keyword=hepatitis B virus kn-keyword=hepatitis B virus en-keyword=lamivudine kn-keyword=lamivudine en-keyword=hepatocellular carcinoma kn-keyword=hepatocellular carcinoma END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=21721 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160217 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis en-subtitle= kn-subtitle= en-abstract= kn-abstract=　Although obesity is undoubtedly major risk for non-alcoholic steatohepatitis (NASH), the presence of lean NASH patients with normal body mass index has been recognized. Here, we report that the insufficiency of phosphatidylethanolamine N-methyltransferase (PEMT) is a risk for the lean NASH. The Pemt−/− mice fed high fat-high sucrose (HFHS) diet were protected from diet-induced obesity and diabetes, while they demonstrated prominent steatohepatitis and developed multiple liver tumors. Pemt exerted inhibitory effects on p53-driven transcription by forming the complex with clathrin heavy chain and p53, and Pemt−/− mice fed HFHS diet demonstrated prominent apoptosis of hepatocytes. Furthermore, hypermethylation and suppressed mRNA expression of F-box protein 31 and hepatocyte nuclear factor 4α resulted in the prominent activation of cyclin D1. PEMT mRNA expression in liver tissues of NASH patients was significantly lower than those with simple steatosis and we postulated the distinct clinical entity of lean NASH with insufficiency of PEMT activities. en-copyright= kn-copyright= en-aut-name=NakatsukaAtsuko en-aut-sei=Nakatsuka en-aut-mei=Atsuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsuyamaMakoto en-aut-sei=Matsuyama en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamaguchiSatoshi en-aut-sei=Yamaguchi en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KatayamaAkihiro en-aut-sei=Katayama en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=EguchiJun en-aut-sei=Eguchi en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MurakamiKazutoshi en-aut-sei=Murakami en-aut-mei=Kazutoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TeshigawaraSanae en-aut-sei=Teshigawara en-aut-mei=Sanae kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OgawaDaisuke en-aut-sei=Ogawa en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=WadaNozomu en-aut-sei=Wada en-aut-mei=Nozomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YasunakaTetsuya en-aut-sei=Yasunaka en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=WatanabeEijiro en-aut-sei=Watanabe en-aut-mei=Eijiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Shigei Medical Research Institute affil-num=3 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Diabetic Nephropathy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=11 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=12 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=13 en-affil= kn-affil=Dainippon Sumitomo Pharma affil-num=14 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=16920 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=2015 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Gpnmb is classified as a type 1 membrane protein and its soluble form is secreted by ADAM10-mediated cleavage. Gpnmb mRNA was found in the Kupffer cells and white adipose tissues (WATs) and its upregulation in obesity was recently found. Here, we generated aP2 promoter-driven Gpnmb transgenic (Tg) mice and the overexpression of Gpnmb ameliorated the fat accumulation and fibrosis of the liver in diet-induced obesity model. Soluble form of Gpnmb in sera was elevated in Gpnmb Tg mice and Gpnmb concentrated in hepatic macrophages and stellate cells interacted with calnexin, which resulted in the reduction of oxidative stress. In the patients with non-alcoholic steatohepatitis, serum soluble GPNMB concentrations were higher compared with the patients with simple steatosis. The GPNMB is a promising biomarker and therapeutic target for the development and progression of NAFLD in obesity. en-copyright= kn-copyright= en-aut-name=KatayamaAkihiro en-aut-sei=Katayama en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakatsukaAtsuko en-aut-sei=Nakatsuka en-aut-mei=Atsuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=EguchiJun en-aut-sei=Eguchi en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MurakamiKazutoshi en-aut-sei=Murakami en-aut-mei=Kazutoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TeshigawaraSanae en-aut-sei=Teshigawara en-aut-mei=Sanae kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KanzakiMotoko en-aut-sei=Kanzaki en-aut-mei=Motoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NunoueTomokazu en-aut-sei=Nunoue en-aut-mei=Tomokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HidaKazuyuki en-aut-sei=Hida en-aut-mei=Kazuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=WadaNozomu en-aut-sei=Wada en-aut-mei=Nozomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YasunakaTetsuya en-aut-sei=Yasunaka en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KiyonariHiroshi en-aut-sei=Kiyonari en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= affil-num=1 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Diabetes and Metabolism, National Hospital Organization Okayama Medical center affil-num=9 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=11 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=12 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=13 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=14 en-affil= kn-affil=Animal Resource Development Unit affil-num=15 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=16 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=4 article-no= start-page=237 end-page=244 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201508 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effectiveness of Extending Treatment Duration in Therapy with Pegylated Interferon and Ribavirin for Genotype 2 Hepatitis C Virus Infection en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effectiveness of extending treatment duration as response guided therapy was previously reported for chronic hepatitis C (CHC) genotype 1, but is still controversial for genotype 2. The present study is a retrospective cohort study to investigate the effectiveness of extending treatment duration in therapy with pegylated interferon and ribavirin for patients with CHC genotype 2 by focusing on the timing at which patients obtained undetectable HCV RNA. A total of 306 patients who obtained undetectable HCV RNA by week 24 of treatment and completed 24 weeks of treatment were enrolled. Rapid virological response (RVR) to standard therapy was achieved by 122 patients (51ｵ), and 89ｵ of them obtained sustained virological response (SVR), while 69ｵ of non-RVR patients achieved SVR. Non-RVR patients with undetectable HCV RNA at week 8, and insufficient adherence＜80ｵ pegylated interferon and ribavirin during the first 24 weeks, significantly improved their SVR rate by extended therapy. Among patients receiving extended therapy, drug adherences did not differ between SVR and non-SVR patients, indicating that extending treatment duration might compensate for insufficient antiviral effects due to insufficient drug adherences. This finding might be useful in creating a guideline for extending treatment duration for patients with CHC genotype 2. en-copyright= kn-copyright= en-aut-name=NanbaShintarou en-aut-sei=Nanba en-aut-mei=Shintarou kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiokaShin-ichi en-aut-sei=Fujioka en-aut-mei=Shin-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ArakiYasuyuki en-aut-sei=Araki en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakaguchiKouichi en-aut-sei=Takaguchi en-aut-mei=Kouichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HashimotoNoriaki en-aut-sei=Hashimoto en-aut-mei=Noriaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SekiHiroyuki en-aut-sei=Seki en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=2 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=3 en-affil= kn-affil=Department of Internal Medicine, Okayama Saiseikai General Hospital affil-num=4 en-affil= kn-affil=Department of Internal Medicine, Hiroshima City Hospital affil-num=5 en-affil= kn-affil=Department of Internal Medicine, Kagawa Prefectural Central Hospital affil-num=6 en-affil= kn-affil=Department of Internal Medicine, Mihara Red Cross Hospital affil-num=7 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=8 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=9 en-affil= kn-affil=Health Service Center, Okayama University affil-num=10 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University en-keyword=hepatitis C virus kn-keyword=hepatitis C virus en-keyword=interferon kn-keyword=interferon en-keyword=genotype 2 kn-keyword=genotype 2 en-keyword=response-guided therapy kn-keyword=response-guided therapy END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=4 article-no= start-page=219 end-page=226 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201508 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Local Recurrence and Complications after Percutaneous Radiofrequency Ablation of Hepatocellular Carcinoma : A Retrospective Cohort Study Focused on Tumor Location en-subtitle= kn-subtitle= en-abstract= kn-abstract=We conducted a retrospective cohort study to investigate the predisposing factors for local recurrence and complications after percutaneous radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC). HCC patients (n＝397) consecutively treated with RFA (256 males, 141 females, median age 69 years) were enrolled. In these patients, 1,455 nodules (median size 17mm) were ablated. Predisposing factors for overall recurrence and local recurrence in the context of tumor location and complications were examined. Local recurrence was observed for 113 of the 1,455 nodules. The 1-, 3- and 5-year local recurrence rates were 2.2ｵ, 7.4ｵ and 9.5ｵ, respectively. A multivariate Cox proportional hazard analysis revealed that large tumor size (＞2cm), tumor location (adjacent to the major portal branch or hepatic vein), and small ablated margin (＜3mm) were independent predisposing factors for local recurrence after RFA (HR＝1.70-2.81). Tumor location (adjacent to the major portal branch, hepatic vein, or diaphragm) was also revealed as a risk factor for liver damage due to RFA. HCC adjacent to the major portal vein or hepatic vein was associated with a higher risk for local recurrence and for complications;therefore, special precautions are necessary when applying RFA to HCC near vessels even when the tumors are located at an easy-to-puncture site. en-copyright= kn-copyright= en-aut-name=ToshimoriJunichi en-aut-sei=Toshimori en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakamuraShinichiro en-aut-sei=Nakamura en-aut-mei=Shinichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=WadaNozomu en-aut-sei=Wada en-aut-mei=Nozomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MorimotoYuki en-aut-sei=Morimoto en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakeuchiYasuto en-aut-sei=Takeuchi en-aut-mei=Yasuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YasunakaTetsuya en-aut-sei=Yasunaka en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KuwakiKenji en-aut-sei=Kuwaki en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OhnishiHideki en-aut-sei=Ohnishi en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=ShirahaHidenori en-aut-sei=Shiraha en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=11 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=12 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=13 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=hepatocellular carcinoma kn-keyword=hepatocellular carcinoma en-keyword=radiofrequency ablation kn-keyword=radiofrequency ablation en-keyword=ablated margin kn-keyword=ablated margin en-keyword=tumor location kn-keyword=tumor location END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=2 article-no= start-page=123 end-page=126 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150803 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of laparoscopic and endoscopic cooperative surgery for sigmoidovesical fistula kn-title=腹腔鏡内視鏡合同手術（Laparoscopy and Endoscopy Cooperative Surgery；LECS） を施行したＳ状結腸膀胱瘻の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We performed laparoscopic and endoscopic cooperative surgery (LECS) for partial colectomy with partial cystectomy in an 80-year-old woman with sigmoidovesical fistula secondary to sigmoid diverticulitis. LECS was designed for local resection of the stomach for gastric submucosal tumors using the endoscopic submucosal dissection (ESD) technique. While conventional open abdominal surgery is very invasive, LECS has enabled surgeons to perform minimally invasive surgery. Although there have been no reported cases in which the bladder was laparoscopically resected after sigmoidovesical fistula division, we were able to safely resect the fistula and preserve the urethral opening by performing laparoscopic and cystoscopic cooperative surgery. There are no previously reported cases in which LECS was performed for partial sigmoidectomy and partial cystectomy ; therefore, we report this as a valuable case, with a review of the literature. We hope that further studies involving more patients will lead to the establishment of this procedure. en-copyright= kn-copyright= en-aut-name=KatoHiroshi en-aut-sei=Kato en-aut-mei=Hiroshi kn-aut-name=加藤大 kn-aut-sei=加藤 kn-aut-mei=大 aut-affil-num=1 ORCID= en-aut-name=OishiMasahiro en-aut-sei=Oishi en-aut-mei=Masahiro kn-aut-name=大石正博 kn-aut-sei=大石 kn-aut-mei=正博 aut-affil-num=2 ORCID= en-aut-name=KoderaMasahito en-aut-sei=Kodera en-aut-mei=Masahito kn-aut-name=小寺正人 kn-aut-sei=小寺 kn-aut-mei=正人 aut-affil-num=3 ORCID= en-aut-name=YamamuraMasao en-aut-sei=Yamamura en-aut-mei=Masao kn-aut-name=山村方夫 kn-aut-sei=山村 kn-aut-mei=方夫 aut-affil-num=4 ORCID= en-aut-name=IkedaHideaki en-aut-sei=Ikeda en-aut-mei=Hideaki kn-aut-name=池田秀明 kn-aut-sei=池田 kn-aut-mei=秀明 aut-affil-num=5 ORCID= en-aut-name=MizunoKenji en-aut-sei=Mizuno en-aut-mei=Kenji kn-aut-name=水野憲治 kn-aut-sei=水野 kn-aut-mei=憲治 aut-affil-num=6 ORCID= en-aut-name=TaniYuma en-aut-sei=Tani en-aut-mei=Yuma kn-aut-name=谷悠真 kn-aut-sei=谷 kn-aut-mei=悠真 aut-affil-num=7 ORCID= en-aut-name=YamashitaYutaka en-aut-sei=Yamashita en-aut-mei=Yutaka kn-aut-name=山下裕 kn-aut-sei=山下 kn-aut-mei=裕 aut-affil-num=8 ORCID= en-aut-name=HayataShunji en-aut-sei=Hayata en-aut-mei=Shunji kn-aut-name=早田俊司 kn-aut-sei=早田 kn-aut-mei=俊司 aut-affil-num=9 ORCID= en-aut-name=KurashigeTakushi en-aut-sei=Kurashige en-aut-mei=Takushi kn-aut-name=倉繁拓志 kn-aut-sei=倉繁 kn-aut-mei=拓志 aut-affil-num=10 ORCID= en-aut-name=NishiyamaYasuhiro en-aut-sei=Nishiyama en-aut-mei=Yasuhiro kn-aut-name=西山康弘 kn-aut-sei=西山 kn-aut-mei=康弘 aut-affil-num=11 ORCID= en-aut-name=NishikawaDaisuke en-aut-sei=Nishikawa en-aut-mei=Daisuke kn-aut-name=西川大祐 kn-aut-sei=西川 kn-aut-mei=大祐 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=鳥取市立病院 affil-num=2 en-affil= kn-affil=鳥取市立病院 affil-num=3 en-affil= kn-affil=鳥取市立病院 affil-num=4 en-affil= kn-affil=鳥取市立病院 affil-num=5 en-affil= kn-affil=鳥取市立病院 affil-num=6 en-affil= kn-affil=鳥取市立病院 affil-num=7 en-affil= kn-affil=鳥取市立病院 affil-num=8 en-affil= kn-affil=鳥取市立病院 affil-num=9 en-affil= kn-affil=鳥取市立病院 affil-num=10 en-affil= kn-affil=鳥取市立病院 affil-num=11 en-affil= kn-affil=鳥取市立病院 affil-num=12 en-affil= kn-affil=鳥取市立病院 en-keyword=結腸膀胱瘻（sigmoidovesical fistula） kn-keyword=結腸膀胱瘻（sigmoidovesical fistula） en-keyword=腹腔鏡内視鏡合同手術（laparoscopic and endoscopic cooperative surgery（LECS）） kn-keyword=腹腔鏡内視鏡合同手術（laparoscopic and endoscopic cooperative surgery（LECS）） END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=3 article-no= start-page=137 end-page=144 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201506 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Aberrant Expression of Keratin 7 in Hepatocytes as a Predictive Marker of Rapid Progression to Hepatic Failure in Asymptomatic Primary Biliary Cirrhosis en-subtitle= kn-subtitle= en-abstract= kn-abstract=A predictive marker of the rapid progression to hepatic failure is desired for patients with asymptomatic primary biliary cirrhosis (aPBC). We performed a systematic cohort analysis of 101 patients diagnosed as having aPBC and the rapid progression to liver failure in some, by focusing on cholestasis. Cholestasis was assessed by aberrant keratin7 (K-7) expressions in the patientsʼ hepatocytes. Intralobular expressions of K-7 were found in 9 of the 101 patients. The grades of K-7 expression were significantly associated with the levels of alanine aminotransferase, alkaline phosphatase, and total bilirubin at the time of diagnosis, but not with bile duct loss or cholestasis. Stepwise logistic regression analysis revealed that high grades of K-7 expression correlated positively with high levels of total bilirubin. During the follow-up period, 8 patients developed jaundice, and the mean period until the development of jaundice was 5.2 years. The proportional hazards models for the risk of developing jaundice identified a high grade of aberrant K-7 expression in hepatocytes as the only significant risk factor. Aberrant K-7 expression in hepatocytes can be used as an additional marker to predict rapid progression to liver failure in patients with aPBC at the time of diagnosis. en-copyright= kn-copyright= en-aut-name=SekiHiroyuki en-aut-sei=Seki en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NanbaShintaro en-aut-sei=Nanba en-aut-mei=Shintaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoritouYuki en-aut-sei=Moritou en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakeuchiYasuto en-aut-sei=Takeuchi en-aut-mei=Yasuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YasunakaTetsuya en-aut-sei=Yasunaka en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OnishiHideki en-aut-sei=Onishi en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MiyakeYasuhiro en-aut-sei=Miyake en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NakamuraMinoru en-aut-sei=Nakamura en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=2 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=3 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=4 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=5 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=6 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=7 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=8 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=9 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=10 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=11 en-affil= kn-affil=Health Service Center, Okayama University affil-num=12 en-affil= kn-affil=Clinical Research Center, National Hospital Organization Nagasaki Medical Center affil-num=13 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, en-keyword=primary biliary cirrhosis kn-keyword=primary biliary cirrhosis en-keyword=keratin 7 kn-keyword=keratin 7 en-keyword=hepatic failure kn-keyword=hepatic failure END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=1 article-no= start-page=25 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Laparoscopic total colectomy with lymph node dissection for familial adenomatous polyposis with multiple colorectal cancers kn-title=家族性大腸腺腫症（FAP）に合併した同時性５多発大腸癌に対してリンパ節郭清を伴う腹腔鏡下大腸全摘術を施行した１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 49-year-old Japanese man visited our hospital with chief complaints of difficulty with and bleeding during defecation. After a detailed examination, he was diagnosed with familial adenomatous polyposis (FAP) with multiple (five) colorectal cancers. The tumors were located in the right-sided, left-sided, and sigmoid colon, and the lower rectum. Regional lymph node involvement was observed, but no metastasis to other organs was detected. We, therefore, performed a laparoscopic total colectomy with superior mesenteric artery (SMA) and inferior mesenteric artery (IMA) lymph node dissection. We were able to perform minimally invasive and cosmetically acceptable surgery using laparoscopy instead of highly-invasive open abdominal surgery. Our search of the literature revealed no reported cases of laparoscopic total colectomy with lymph node dissection for FAP with multiple colorectal cancers, making the present case the first to be reported in the literature. en-copyright= kn-copyright= en-aut-name=KatoHiroshi en-aut-sei=Kato en-aut-mei=Hiroshi kn-aut-name=加藤大 kn-aut-sei=加藤 kn-aut-mei=大 aut-affil-num=1 ORCID= en-aut-name=OishiMasahiro en-aut-sei=Oishi en-aut-mei=Masahiro kn-aut-name=大石正博 kn-aut-sei=大石 kn-aut-mei=正博 aut-affil-num=2 ORCID= en-aut-name=KoderaMasahito en-aut-sei=Kodera en-aut-mei=Masahito kn-aut-name=小寺正人 kn-aut-sei=小寺 kn-aut-mei=正人 aut-affil-num=3 ORCID= en-aut-name=YamamuraMasao en-aut-sei=Yamamura en-aut-mei=Masao kn-aut-name=山村方夫 kn-aut-sei=山村 kn-aut-mei=方夫 aut-affil-num=4 ORCID= en-aut-name=IkedaHideaki en-aut-sei=Ikeda en-aut-mei=Hideaki kn-aut-name=池田秀明 kn-aut-sei=池田 kn-aut-mei=秀明 aut-affil-num=5 ORCID= en-aut-name=MizunoKenji en-aut-sei=Mizuno en-aut-mei=Kenji kn-aut-name=水野憲治 kn-aut-sei=水野 kn-aut-mei=憲治 aut-affil-num=6 ORCID= en-aut-name=YamashitaYutaka en-aut-sei=Yamashita en-aut-mei=Yutaka kn-aut-name=山下裕 kn-aut-sei=山下 kn-aut-mei=裕 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=鳥取市立病院　外科 affil-num=2 en-affil= kn-affil=鳥取市立病院　外科 affil-num=3 en-affil= kn-affil=鳥取市立病院　外科 affil-num=4 en-affil= kn-affil=鳥取市立病院　外科 affil-num=5 en-affil= kn-affil=鳥取市立病院　外科 affil-num=6 en-affil= kn-affil=鳥取市立病院　外科 affil-num=7 en-affil= kn-affil=鳥取市立病院　外科 en-keyword=家族性大腸腺腫症（FAP）（familial adenomatous polyposis） kn-keyword=家族性大腸腺腫症（FAP）（familial adenomatous polyposis） en-keyword=同時性多発大腸癌（synchronous colorectal cancer） kn-keyword=同時性多発大腸癌（synchronous colorectal cancer） en-keyword=大腸全摘術（colorectal surgery） kn-keyword=大腸全摘術（colorectal surgery） en-keyword=腹腔鏡下手術（laparoscopic surgery） kn-keyword=腹腔鏡下手術（laparoscopic surgery） END start-ver=1.4 cd-journal=joma no-vol=158 cd-vols= no-issue= article-no= start-page=115 end-page=118 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The field for KEMARI play in the Okayama Korakuen in the Edo era was found. kn-title=「御鞠場」がある池田家文庫絵図の発見（短報） en-subtitle= kn-subtitle= en-abstract= kn-abstract=　岡山大学図書館が管理する「池田家文庫」の絵図を調べるうち，今までその存在が曖昧で あった蹴鞠場の位置を明確に示す絵図を発見した。その絵図そのものは，すでに後楽園の歴 史の解説書などにも使用されているものであったが，なぜか「御鞠場」に誰も注目していな かった。池田家文庫では絵図は原則として「Ｔ７」という項目に分類されており，その中に は後楽園の敷地内全体の建物配置が分かる情報を含む絵図も何枚かあることは良く知られて いたが，「Ｔ７」以外の分類項目の中からも，同様の情報が得られる絵図があるかも知れな いとの期待のもとに，検索範囲を広げた結果，「Ｔ６」の中に「御鞠場」と記された建物が 存在する絵図があった。また，その絵図の成立推定年は池田家文庫では未詳とされているが， 早くて1786 年，遅くても1815 年という結果が得られたので報告する。 en-copyright= kn-copyright= en-aut-name=SahashiKen en-aut-sei=Sahashi en-aut-mei=Ken kn-aut-name=佐橋謙 kn-aut-sei=佐橋 kn-aut-mei=謙 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=岡山後楽園 kn-keyword=岡山後楽園 en-keyword=池田家文庫 kn-keyword=池田家文庫 en-keyword=蹴鞠場 kn-keyword=蹴鞠場 END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=11 article-no= start-page=1172 end-page=1182 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=201011 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Laparoscopic findings of reddish markings predict hepatocellular carcinoma in patients with hepatitis B virus-related liver disease en-subtitle= kn-subtitle= en-abstract= kn-abstract=For patients with chronic hepatitis due to hepatitis B virus (HBV), factors predicting hepatocellular carcinoma (HCC) other than high levels of HBV-DNA and alanine aminotransferase (ALT) are needed to prevent HCC development, as many patients with chronic HBV infection fulfill these conditions. The purpose of this study was to clarify factors predictive of HCC development for those patients. The study was a systematic cohort analysis of 303 consecutive patients with hepatitis B e-antigen, receiving laparoscopic examination for assessment of liver disease. Laparoscopic, histological, and clinical characteristics were investigated as related to HCC development. HCC occurred in 27 patients during a mean follow-up of 8.0 +/- A 5.0 years, at the age of 37-72 years. Significant associations with HCC development were shown for liver cirrhosis, histological activity grade, reddish markings, and older age. Multivariate analysis revealed that HCC development was strongly associated with older age and male gender (P = 0.002 and P = 0.043, respectively). HCC occurred more frequently in patients of age a parts per thousand yen30 years even with early stage than in patients of age < 30 years (P = 0.031). Severe reddish markings, a laparoscopic finding of widespread parenchymal destruction, were highly associated with HCC development in patients of age a parts per thousand yen30 years at diagnosis (odds ratio = 1.67, P = 0.034), while histological activity grade and ALT level were not (P = 0.075 and P = 0.69, respectively). HCC development is associated with older age, male gender, and liver cirrhosis. Reddish markings, rather than histological activity or ALT level, can be useful to predict HCC for HBV patients of age a parts per thousand yen30 years. en-copyright= kn-copyright= en-aut-name=ShojiBon en-aut-sei=Shoji en-aut-mei=Bon kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiokaShin-ichi en-aut-sei=Fujioka en-aut-mei=Shin-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KobashiHaruhiko en-aut-sei=Kobashi en-aut-mei=Haruhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YasunakaTetsuya en-aut-sei=Yasunaka en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyakeYasuhiro en-aut-sei=Miyake en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShirahaHidenori en-aut-sei=Shiraha en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=2 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=3 en-affil= kn-affil=Okayama Saiseikai Gen Hosp, Dept Internal Med affil-num=4 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=5 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=6 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=7 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=8 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=9 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=10 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=11 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci en-keyword=Hepatitis B virus kn-keyword=Hepatitis B virus en-keyword=Hepatocellular carcinoma kn-keyword=Hepatocellular carcinoma en-keyword=Laparoscopy kn-keyword=Laparoscopy END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=7 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140701 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=L-Carnitine Prevents Progression of Non-Alcoholic Steatohepatitis in a Mouse Model with Upregulation of Mitochondrial Pathway en-subtitle= kn-subtitle= en-abstract= kn-abstract=Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease characterized by lobular inflammation, hepatocellular ballooning, and fibrosis with an inherent risk for progression to cirrhosis and hepatocellular carcinoma (HCC). Mitochondrial dysfunction appears to play a role in the progression from simple steatosis to NASH. L-carnitine (L-b-hydroxy-g-N-trimethylaminobutyric acid), an essential nutrient that converts fat into energy in mitochondria, has been shown to ameliorate liver damage. The aim of the present study was to explore the preventive and therapeutic effect of L-carnitine in NASH model mice. Eight-week-old male STAM mice, a NASH-cirrhosis-hepatocarcinogenic model, were divided into 3 experimental groups and fed as follows: 1) high-fat diet (HFD) (control group); 2) HFD mixed with 0.28% L-carnitine (L-carnitine group); and 3) HFD mixed with 0.01% alpha-tocopherol (alpha-tocopherol group). After 4 or 8 weeks, mice were sacrificed. Blood samples and livers were collected, and hepatic tumors were counted and measured. Livers were subjected to histological study, immunohistochemical staining of 4-hydroxynonenal and ferritin, determination of 8-OHdG levels, mRNA and protein expressions for multiple genes, and metabolomic analysis. The intestinal microbiome was also analyzed. L-carnitine increased hepatic expression of genes related to long-chain fatty acid transport, mitochondrial beta-oxidation, and antioxidant enzymes following suppression of hepatic oxidative stress markers and inflammatory cytokines in NASH, and mice treated with L-carnitine developed fewer liver tumors. Although alpha-tocopherol resulted in NASH improvement in the same manner as L-carnitine, it increased periodontitis-related microbiotic changes and hepatic iron transport-related gene expression and led to less effective for anti-hepatocarcinogenesis. Conclusion: L-carnitine prevents progression of non-alcoholic steatohepatitis in a mouse model by upregulating the mitochondrial beta-oxidation and redox system. en-copyright= kn-copyright= en-aut-name=IshikawaHisashi en-aut-sei=Ishikawa en-aut-mei=Hisashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TsuzakiRyuichiro en-aut-sei=Tsuzaki en-aut-mei=Ryuichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YasunakaTetsuya en-aut-sei=Yasunaka en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KoikeKazuko en-aut-sei=Koike en-aut-mei=Kazuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShimomuraYasuyuki en-aut-sei=Shimomura en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SekiHiroyuki en-aut-sei=Seki en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MatsushitaHiroshi en-aut-sei=Matsushita en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MiyakeYasuhiro en-aut-sei=Miyake en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=ShirahaHidenori en-aut-sei=Shiraha en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=2 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=3 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=4 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=5 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=6 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=7 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=8 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=9 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=10 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=11 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=12 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=13 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue= article-no= start-page=1 end-page=4 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Improvement of dye-mediated dehydrogenase activity of pyranose oxidase by site-directed mutagenesis kn-title=部位特異的変異によるピラノース酸化酵素の色素依存性脱水素酵素活性の向上 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　Pyranose oxidase (EC 1.1.3.10 ; PROD) catalyzes the oxidation of aldopyranoses at the position C‒2 to yield the corresponding 2‒keto-aldoses and H2O2 , using oxygen as an electron acceptor. The enzyme shows broad substrate specificity as well as reactivity for 1,5‒anhydro‒d‒glucitol (1,5‒AG), which is known as a clinical glycemic marker. It is considered that the reactivity of PROD for 1,5‒AG is useful in the development of an amperometric-type biosensor, which is a convenient diagnostic device for selfmonitoring blood glucose (SMBG). However, the levels of dissolved oxygen in blood affect biosensor systems that are equipped with an artificial electron mediator. In the present study, we attempted to develop an O2‒insensitive oxidase that would improve the dye-mediated dehydrogenase activity. We performed site-directed mutagenesis on PROD isolated from basidiomycetous fungus No. 52, which generated 11 mutants. The amino acid substitution Q421A exhibited a significant decrease (8.8% of wild type) in its oxidase activity, whereas it maintained its dehydrogenase activity (67% of wild type). In this study, we characterized PROD mutants from basidiomycetous fungus No. 52, which showed improved dye-mediated dehydrogenase activity. en-copyright= kn-copyright= en-aut-name=ArakiToshio en-aut-sei=Araki en-aut-mei=Toshio kn-aut-name=荒木俊雄 kn-aut-sei=荒木 kn-aut-mei=俊雄 aut-affil-num=1 ORCID= en-aut-name=NakatsukaTomoko en-aut-sei=Nakatsuka en-aut-mei=Tomoko kn-aut-name=中柄朋子 kn-aut-sei=中柄 kn-aut-mei=朋子 aut-affil-num=2 ORCID= en-aut-name=TamuraTakashi en-aut-sei=Tamura en-aut-mei=Takashi kn-aut-name=田村隆 kn-aut-sei=田村 kn-aut-mei=隆 aut-affil-num=3 ORCID= en-aut-name=InagakiKenji en-aut-sei=Inagaki en-aut-mei=Kenji kn-aut-name=稲垣賢二 kn-aut-sei=稲垣 kn-aut-mei=賢二 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=池田食研株式会社 affil-num=2 en-affil= kn-affil=池田食研株式会社 affil-num=3 en-affil= kn-affil=岡山大学農学部 affil-num=4 en-affil= kn-affil=岡山大学農学部 en-keyword=pyranose oxidase kn-keyword=pyranose oxidase en-keyword=1,5-anhydro-d-glucitol kn-keyword=1,5-anhydro-d-glucitol en-keyword=biosensor kn-keyword=biosensor en-keyword=site-directed mutagenesis kn-keyword=site-directed mutagenesis en-keyword=SMBG kn-keyword=SMBG END start-ver=1.4 cd-journal=joma no-vol=48 cd-vols= no-issue=3 article-no= start-page=405 end-page=412 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201303 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The impact of patatin-like phospholipase domain-containing protein 3 polymorphism on hepatocellular carcinoma prognosis en-subtitle= kn-subtitle= en-abstract= kn-abstract=The single nucleotide polymorphism (SNP) rs738409 in patatin-like phospholipase domain-containing protein 3 (PNPLA3) is associated with hepatic fat accumulation and disease progression in patients with non-alcoholic fatty liver disease and alcoholic liver disease (ALD). This study was conducted to determine whether PNPLA3 rs738409 SNPs affect development and prognosis of hepatocellular carcinoma (HCC) in patients with various liver diseases. We enrolled 638 consecutive Japanese patients newly diagnosed with HCC between 2001 and 2010: 72 patients with hepatitis B virus (HBV), 462 with hepatitis C virus (HCV), and 104 with non-B non-C (NBNC). NBNC patients exhibited large tumors of advanced TNM stages at HCC diagnosis, and had significantly poorer prognosis than HBV or HCV patients (P < 0.001 and < 0.001, respectively; log-rank test). The G/G genotype of PNPLA3 rs738409 SNP had significantly higher distribution in NBNC patients (P < 0.001) and was significantly associated with higher body mass index (BMI) and an increased aspartate aminotransferase to platelet ratio index. No significant differences were observed in survival with differences in PNPLA3 SNP genotypes among the patients, although ALD patients with the G/G genotype of PNPLA3 SNP and low BMI had significantly poorer survival than those with high BMI (P = 0.028). The G/G genotype of PNPLA3 rs738409 SNP was more frequently distributed, and associated with BMI and fibrosis among NBNC-HCC patients but not among HBV or HCV patients. These genotypes might affect HCC prognosis in ALD patients, but not in HBV, HCV, or NAFLD patients. en-copyright= kn-copyright= en-aut-name=TakeuchiYasuto en-aut-sei=Takeuchi en-aut-mei=Yasuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MoritouYuki en-aut-sei=Moritou en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HagiharaHiroaki en-aut-sei=Hagihara en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YasunakaTetsuya en-aut-sei=Yasunaka en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KuwakiKenji en-aut-sei=Kuwaki en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MiyakeYasuhiro en-aut-sei=Miyake en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OhnishiHideki en-aut-sei=Ohnishi en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NakamuraShinichiro en-aut-sei=Nakamura en-aut-mei=Shinichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=ShirahaHidenori en-aut-sei=Shiraha en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=2 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=3 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=4 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=5 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=6 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=7 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=8 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=9 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=10 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=11 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=12 en-affil= kn-affil=Okayama Univ, Hlth & Environm Ctr affil-num=13 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=14 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol en-keyword=Hepatocellular carcinoma kn-keyword=Hepatocellular carcinoma en-keyword=PNPLA3 SNP kn-keyword=PNPLA3 SNP en-keyword=Survival kn-keyword=Survival END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=2 article-no= start-page=544 end-page=548 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Necessity for Reassessment of Patients with Serogroup 2 Hepatitis C Virus (HCV) and Undetectable Serum HCV RNA en-subtitle= kn-subtitle= en-abstract= kn-abstract=We encountered a patient positive for anti-hepatitis C virus (HCV) whose serum HCV RNA was undetectable with the Roche AmpliPrep/Cobas TaqMan HCV assay (CAP/CTM) version 1 but showed a high viral load with the Abbott RealTime HCV assay (ART). Discrepancies in the detectability of serum HCV RNA were investigated among 891 consecutive patients who were positive for anti-HCV. Specific nucleotide variations causing the undetectability of HCV RNA were determined and confirmed by synthesizing RNA coding those variations. Serum samples with the discrepancies were also reassessed by CAP/CTM version 2. Among the 891 anti-HCV-positive patients, 4 patients had serum HCV RNA levels that were undetectable by CAP/CTM version 1 despite having levels of > 5 log IU/ml that were detected by ART. All four patients had HCV genotype 2a and high titers of anti-HCV. Sequencing of the HCV 5' noncoding regions revealed 2 common variations, A at nucleotide (nt) 145 and T at nt 151. Synthesized RNAs of the HCV 5' noncoding region with standard (NCR145G151C) and variant nucleotides at nt 145 and nt 151 were quantified with CAP/CTM. RNAs of NCR145G151C and NCR145G151T were quantifiable with CAP/CTM version 1, while those of NCR145A151T and NCR145A151C went undetected. The substitution from G to A at nt 145 specifically conferred this undetectability, while this undetectability was reverted in synthesized HCV RNA with correction of this variation. Reassessment of these samples by CAP/CTM version 2 resulted in similar levels of HCV RNA being detected by ART. We conclude that HCV patients with undetectable HCV RNA by CAP/CTM version 1 should be reassessed for viral quantification. en-copyright= kn-copyright= en-aut-name=MoritouYuki en-aut-sei=Moritou en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakeuchiYasuto en-aut-sei=Takeuchi en-aut-mei=Yasuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SekiHiroyuki en-aut-sei=Seki en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NanbaShintaro en-aut-sei=Nanba en-aut-mei=Shintaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=2 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=3 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=4 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=5 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=6 en-affil= kn-affil=Okayama Univ, Hlth Serv Ctr affil-num=7 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci END start-ver=1.4 cd-journal=joma no-vol=157 cd-vols= no-issue= article-no= start-page=(21) end-page=(27) dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20141127 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Consideration of the Ichinomiya system based on Bizen Kibitsunomiya kn-title=備前吉備津宮からみた一宮制 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　備前一宮とされる吉備津宮に関連する「備前国一宮社法」「備前国総社家社僧中神前御祈念之事等注文」「備前一宮御神事絵巻」は、室町時 代の年紀を有し、中世史料と考えられてきた。しかし、人名、地名、および「国主」という用語に即して関連史料を探索してみると、近世初 期に成立した史料と考えられる。それでも史料の作成者が、康永や文明など中世の年号を付したのは、中世松田氏が近世池田氏の前身だとい う近世初期の歴史認識の現れと考察した。 en-copyright= kn-copyright= en-aut-name=SaitoNatsuki en-aut-sei=Saito en-aut-mei=Natsuki kn-aut-name=斎藤夏来 kn-aut-sei=斎藤 kn-aut-mei=夏来 aut-affil-num=1 ORCID= en-aut-name=TabuchiHikaru en-aut-sei=Tabuchi en-aut-mei=Hikaru kn-aut-name=田淵光 kn-aut-sei=田淵 kn-aut-mei=光 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院教育学研究科　社会・言語教育学系 affil-num=2 en-affil= kn-affil=クラブン株式会社 en-keyword=備前吉備津宮 kn-keyword=備前吉備津宮 en-keyword=備前国一宮社法 kn-keyword=備前国一宮社法 en-keyword=備前国総社家社僧中神前御祈念之事等注文 kn-keyword=備前国総社家社僧中神前御祈念之事等注文 en-keyword=備前一宮御神事絵巻 kn-keyword=備前一宮御神事絵巻 en-keyword=国主 kn-keyword=国主 en-keyword=松田氏 kn-keyword=松田氏 END start-ver=1.4 cd-journal=joma no-vol=157 cd-vols= no-issue= article-no= start-page=43 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20141127 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Air Temperature at the Heat Shelter Settled by the Lord Mitsumasa Ikeda in Early Edo Era Near the Urban Area of Okayama. kn-title=池田光政公の御涼所の気温について en-subtitle= kn-subtitle= en-abstract= kn-abstract=　ある記録（有斐録）によると，江戸初期の備前藩主池田光政公は，「御涼所」を現在の岡 山市北区中原のあたりに定め，そこで暑さを凌いでいたそうである。 　本論は，実際に夏期好晴日に岡山城近くと，中原での気温を測定し，それが二カ所でどの ように違うか違わないかを調べた結果を示したものである。夏の好晴日だと10 分間程度の 短い間では５℃，一時間程度の長い間の平均値でも２℃程度，御涼所の方が低温であること があることがわかった。つまり当時でも人が多かったであろう城下町より，大幅に低温であ っただろうことが推定される。 en-copyright= kn-copyright= en-aut-name=SahashiKen en-aut-sei=Sahashi en-aut-mei=Ken kn-aut-name=佐橋謙 kn-aut-sei=佐橋 kn-aut-mei=謙 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院教育学研究科 en-keyword=江戸時代 kn-keyword=江戸時代 en-keyword=池田光政公御涼所 kn-keyword=池田光政公御涼所 en-keyword=気温 kn-keyword=気温 END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=3 article-no= start-page=223 end-page=226 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20141201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of microscopic low-grade appendiceal mucinous neoplasm complicated with appendicitis resected by reduced-port laparoscopic surgery kn-title=Reduced Port Surgeryで切除した高度炎症を伴う虫垂中に発見された潜在性虫垂粘液嚢胞腺腫の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Appendicitis is a benign disease for which surgical treatment is widely provided. The complication of neoplastic lesions may be discovered only after resection. However, in some cases, specimens are not submitted to histopathological examination in Japan because of an extreme deficiency of pathologists. We report our experience with one patient who experienced the complication of latent low-grade appendiceal mucinous neoplasm (LAMN) after surgery for appendicitis. Our patient was an 85-year-old woman. Conservative treatment failed to relieve fever and lower abdominal pain and it was decided to treat her surgically. Abdominal computed tomography (CT) showed appendicitis with severe inflammation and suspected adhesion. We decided to explore the abdominal cavity using a reduced-port laparoscopic approach. We found no mucous debouchment or clear tumors in the specimen. Histopathological findings indicated the coexistence of appendicitis and LAMN. At one year and a half after surgery, there was no evidence of the development of pseudomyxoma peritonei. In appendectomy, it is thought that careful perioperative treatment and a postoperative pathological search are important when there are no preoperative findings suggesting a neoplastic lesion. en-copyright= kn-copyright= en-aut-name=SuzukiHiromitsu en-aut-sei=Suzuki en-aut-mei=Hiromitsu kn-aut-name=鈴木宏光 kn-aut-sei=鈴木 kn-aut-mei=宏光 aut-affil-num=1 ORCID= en-aut-name=KimuraKouji en-aut-sei=Kimura en-aut-mei=Kouji kn-aut-name=木村紘爾 kn-aut-sei=木村 kn-aut-mei=紘爾 aut-affil-num=2 ORCID= en-aut-name=KinoshitaSigeki en-aut-sei=Kinoshita en-aut-mei=Sigeki kn-aut-name=木下茂喜 kn-aut-sei=木下 kn-aut-mei=茂喜 aut-affil-num=3 ORCID= en-aut-name=OkanoKazuo en-aut-sei=Okano en-aut-mei=Kazuo kn-aut-name=岡野和雄 kn-aut-sei=岡野 kn-aut-mei=和雄 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=倉敷市立児島市民病院　外科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　呼吸器・乳腺内分泌外科学 affil-num=3 en-affil= kn-affil=倉敷市立児島市民病院　外科 affil-num=4 en-affil= kn-affil=倉敷市立児島市民病院　外科 en-keyword=虫垂炎（appendicitis） kn-keyword=虫垂炎（appendicitis） en-keyword=減孔式腹腔鏡手術（reduced-port laparoscopic surgery） kn-keyword=減孔式腹腔鏡手術（reduced-port laparoscopic surgery） en-keyword=虫垂粘液嚢胞腺腫（low-grade appendiceal mucinous neoplasm (LAMN)） kn-keyword=虫垂粘液嚢胞腺腫（low-grade appendiceal mucinous neoplasm (LAMN)） en-keyword=腹膜偽粘液腫（pseudomyxoma peritonei） kn-keyword=腹膜偽粘液腫（pseudomyxoma peritonei） en-keyword=腹腔鏡下虫垂切除術（laparoscopic appendectomy） kn-keyword=腹腔鏡下虫垂切除術（laparoscopic appendectomy） END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=5 article-no= start-page=291 end-page=302 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201410 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Hepatitis C Virus-specific T-cell Response Correlates with Hepatitis Activity and Donor IL28B Genotype Early after Liver Transplantation en-subtitle= kn-subtitle= en-abstract= kn-abstract=It is not known how the immune system targets hepatitis C virus (HCV)-infected HLA-mismatched hepatocytes under immune-suppressed conditions after orthotopic liver transplantation (OLT). In addition, the relationship between the HCV-specific immune response and IL28B variants as predictors of HCV clearance has not been well-characterized. We determined the IL28B polymorphisms for 57 post-OLT HCV carriers, and we assessed the HCV-specific immune responses by measuring the peripheral blood mononuclear cell-derived HCV-specific interferon-gamma (IFN-γ) response using an enzyme-linked immunospot assay. At 1-3 years after OLT, patients with no active hepatitis showed higher total spots on the immunospot assay. At＞3 years after OLT, patients with resolved HCV showed higher levels of core, NS3, NS5A, and total spots compared to the chronic hepatitis patients. The IL28B major genotype in the donors correlated with higher spot counts for NS5A and NS5B proteins at 1-3 years after OLT. In the post-OLT setting, the HCV-specific immune response could be strongly induced in patients with no active hepatitis with an IL28B major donor or sustained virological response. Strong immune responses in the patients with no active hepatitis could only be maintained for 3 years and diminished later. It may be beneficial to administer IFN treatment starting 3 years after OLT, to induce the maximum immunological effect. en-copyright= kn-copyright= en-aut-name=TsuzakiRyuichiro en-aut-sei=Tsuzaki en-aut-mei=Ryuichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YagiTakahito en-aut-sei=Yagi en-aut-mei=Takahito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KoikeKazuko en-aut-sei=Koike en-aut-mei=Kazuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShirahaHidenori en-aut-sei=Shiraha en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MiyakeYasuhiro en-aut-sei=Miyake en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SadamoriHiroshi en-aut-sei=Sadamori en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=ShinouraSusumu en-aut-sei=Shinoura en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=UmedaYuzo en-aut-sei=Umeda en-aut-mei=Yuzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YoshidaRyuichi en-aut-sei=Yoshida en-aut-mei=Ryuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=NobuokaDaisuke en-aut-sei=Nobuoka en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=UtsumiMasashi en-aut-sei=Utsumi en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=NakayamaEiichi en-aut-sei=Nakayama en-aut-mei=Eiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= affil-num=1 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Gastroenterological Surgery Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Health Service Center, Okayama University affil-num=7 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Gastroenterological Surgery Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of Gastroenterological Surgery Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=11 en-affil= kn-affil=Department of Gastroenterological Surgery Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=12 en-affil= kn-affil=Department of Gastroenterological Surgery Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=13 en-affil= kn-affil=Department of Gastroenterological Surgery Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=14 en-affil= kn-affil=Department of Gastroenterological Surgery Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=15 en-affil= kn-affil=Kawasaki University of Medical Welfare affil-num=16 en-affil= kn-affil=Department of Gastroenterological Surgery Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=17 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=interferon gamma kn-keyword=interferon gamma en-keyword=ELISPOT assay kn-keyword=ELISPOT assay en-keyword=single nucleotide polymorphisms kn-keyword=single nucleotide polymorphisms en-keyword=dendritic cell kn-keyword=dendritic cell en-keyword=CD4 T cell kn-keyword=CD4 T cell END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=5 article-no= start-page=263 end-page=268 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201410 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Nursing Support Increases the Efficacy of Interferon Therapy in Patients with Chronic Hepatitis C en-subtitle= kn-subtitle= en-abstract= kn-abstract=Nursing support might help patients with chronic hepatitis C (CHC) remain in good mental and physical condition during interferon (IFN) therapy. However, the effects of nursing support have not been studied adequately in this context. This case-control study evaluated the effects of nursing support during IFN therapy. Twenty-four CHC patients who received pegylated IFN and ribavirin were enrolled. Nurses advised patients on the maintenance of their mental and physical condition at weekly visits, based on the results of written questionnaires. An additional 24 patients who received IFN therapy without nursing support and who were matched for age, sex, platelet count, viral serogroup and IFN regimen were selected with propensity score matching as controls. The patients with nursing support during IFN therapy achieved higher sustained virological responses (79%) than those without nursing support (58%). Adherence to the IFN and ribavirin regimens at 24 weeks of therapy were slightly higher in the patients with nursing support than those without it, but these differences were not statistically significant. Adherence to ribavirin after 24 weeks of therapy was significantly higher in those with nursing support than those without it (93% and 66%, p＝0.045). These results suggested that nursing support services could contribute to the virological responses of CHC patients by promoting drug-regimen adherence. en-copyright= kn-copyright= en-aut-name=NambaShihoko en-aut-sei=Namba en-aut-mei=Shihoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyakeKayoko en-aut-sei=Miyake en-aut-mei=Kayoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HazamaTomoko en-aut-sei=Hazama en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HitobeYu en-aut-sei=Hitobe en-aut-mei=Yu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamasakiNoriko en-aut-sei=Yamasaki en-aut-mei=Noriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShirahaHidenori en-aut-sei=Shiraha en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=Department of Nursing, Okayama University Hospital affil-num=2 en-affil= kn-affil=Department of Nursing, Okayama University Hospital affil-num=3 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Nursing, Okayama University Hospital affil-num=5 en-affil= kn-affil=Department of Nursing, Okayama University Hospital affil-num=6 en-affil= kn-affil=Department of Nursing, Okayama University Hospital affil-num=7 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Health Service Center, Okayama University affil-num=11 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=chronic hepatitis C kn-keyword=chronic hepatitis C en-keyword=nursing support kn-keyword=nursing support en-keyword=interferon therapy kn-keyword=interferon therapy END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue=2 article-no= start-page=337 end-page=343 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Assessment of health-related quality of life and how it predicts the outcome of pegylated interferon and ribavirin therapy for chronic hepatitis C en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background and Aim: Chronic infection with hepatitis C virus (HCV) decreases health-related quality of life (HRQOL). The present study was planned to investigate the impact of HRQOL of patients with chronic hepatitis C (CHC) on the outcomes of therapy with pegylated interferon and ribavirin (RBV), in addition to IL28B polymorphisms. Methods: The present study enrolled 228 CHC patients and assessed their HRQOLs prospectively with the 36-item short-form health survey. Results: The patients with CHC have lower physical HRQOL status than the general population (P = 0.037, the Z-test). The patients with advanced liver diseases exhibited further decreases in HRQOL (P = 0.036, Spearman's rank correlation coefficient). The score of total HRQOL was significantly lower in the group with sustained virological response (SVR) to the therapy with pegylated interferon and RBV than the non-SVR group (P = 0.031, the Mann-Whitney U-test), with significantly lower scores of mental component and its comprising subscales in the SVR group. Stepwise multivariate logistic regression analysis showed that low HRQOL score <= 400 points was significantly associated with SVR (odds ratio = 2.4, P = 0.013), independently from high platelet counts, low HCV RNA, favorable single-nucleotide polymorphism type of IL28B, and HCV serotype 2. The patients with low HRQOL score will have significantly less decrease in HRQOL score by 4 weeks of the treatment than those with high HRQOL score at baseline (P = 0.0045). Conclusion: HRQOL is one of the significant predictor of the outcomes of therapy with pegylated interferon and RBV independently from IL28B polymorphism. en-copyright= kn-copyright= en-aut-name=MatsushitaHiroshi en-aut-sei=Matsushita en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SekiHiroyuki en-aut-sei=Seki en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NanbaShintaro en-aut-sei=Nanba en-aut-mei=Shintaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakeuchiYasuto en-aut-sei=Takeuchi en-aut-mei=Yasuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MoritouYuki en-aut-sei=Moritou en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YasunakaTetsuya en-aut-sei=Yasunaka en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OnishiHideki en-aut-sei=Onishi en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MiyakeYasuhiro en-aut-sei=Miyake en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=2 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=3 en-affil= kn-affil=Okayama Univ, Hlth Serv Ctr affil-num=4 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=5 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=6 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=7 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=8 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=9 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=10 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=11 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=12 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci affil-num=13 en-affil= kn-affil=Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci en-keyword=HCV kn-keyword=HCV en-keyword=interferon kn-keyword=interferon en-keyword=QOL kn-keyword=QOL END start-ver=1.4 cd-journal=joma no-vol=86 cd-vols= no-issue=2 article-no= start-page=122 end-page=128 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=2012 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Serum Levels of Soluble Adhesion Molecules as Prognostic Factors for Acute Liver Failure en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background/Aims: In patients with septic shock, the degree of liver dysfunction is correlated with serum levels of soluble intercellular adhesion molecule (sICAM)-1. We aimed to assess the usefulness of serum levels of soluble adhesion molecules as prognostic factors for acute liver failure (ALF). Methods: Serum levels of soluble platelet endothelial cell adhesion molecule (sPECAM)-1, sICAM-3, soluble endothelial (sE) selectin, sICAM-1, soluble platelet selectin, and soluble vascular cell adhesion molecule-1 on admission were measured in 37 ALF patients and 34 healthy controls. Results: Twenty-two ALF patients (59%) reached to fatal outcomes. Serum levels of sPECAM-1, sICAM-3, sE-selectin and sICAM-1 were higher in ALF patients than healthy controls. In 37 ALF patients, by the multivariate logistic regression analysis, ratio of direct to total bilirubin (per 0.1 increase; OR 0.11, 95% CI 0.01-0.99), serum sPECAM-1 level (per 100 ng/ml increase; OR 4.37, 95% CI 1.23-15.5) and serum sICAM-1 level (per 100 ng/ml increase; OR 0.49, 95% CI 0.27-0.89) were associated with fatal outcomes. Using receiver operating characteristics curve, each area under the curve of serum sPECAM-1 and sICMA-1 levels as prognostic factors was 0.71 and 0.74, respectively. Conclusion: Serum sPECAM-1 and sICAM-1 levels may be useful for predicting the prognosis of ALF. en-copyright= kn-copyright= en-aut-name=OhnishiAtsuyuki en-aut-sei=Ohnishi en-aut-mei=Atsuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyakeYasuhiro en-aut-sei=Miyake en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsushitaHiroshi en-aut-sei=Matsushita en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MatsumotoKazuyuki en-aut-sei=Matsumoto en-aut-mei=Kazuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YasunakaTetsuya en-aut-sei=Yasunaka en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KoikeKazuko en-aut-sei=Koike en-aut-mei=Kazuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ShirahaHidenori en-aut-sei=Shiraha en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=2 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=3 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=4 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=5 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=6 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=7 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=8 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=9 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=10 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=11 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol en-keyword=Acute liver failure kn-keyword=Acute liver failure en-keyword=Intercellular adhesion molecule-1 kn-keyword=Intercellular adhesion molecule-1 en-keyword=Liver transplantation kn-keyword=Liver transplantation en-keyword=Platelet endothelial cell adhesion molecule-1 kn-keyword=Platelet endothelial cell adhesion molecule-1 en-keyword=Prognosis kn-keyword=Prognosis END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=4 article-no= start-page=243 end-page=247 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Prevalence and Outcomes of Acute Hepatitis B in Okayama, Japan, 2006-2010 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Hepatitis B virus (HBV) is one of the major viruses causing acute hepatitis. Recently, the incidence of acute hepatitis with genotype A has been increasing in Japan. The aim of this study was to investigate acute hepatitis B (AHB) in Okayama prefecture, with special attention to HBV genotype A. AHB patients who visited one of 12 general hospitals in Okayama prefecture between 2006 and 2010 were retrospectively analyzed. Over the course of the study period, 128 patients were diagnosed with AHB. Sexual transmission was supposed in the majority of patients (78 patients, 61%), including 59 (76%) having sex with heterosexual partners. The genotypes of HBV were assessed in 90 patients (70%), of whom 27 patients were infected with genotype A, 5 with genotype B, and 58 with genotype C. The prevalence of genotype A was significantly higher among male patients (28.7%), aged 20-29 (35.6%, p＜0.01), among men who had sex with men (100%, p＜0.005), and among patients having sex with unspecified partners (44.8%, p＜0.005). Genotype A was not a significant factor associated with delayed HBsAg disappearance. Caution should be exercised with regard to sexually transmissible diseases in order to slow the pandemic spread of AHB due to genotype A. en-copyright= kn-copyright= en-aut-name=WadaNozomu en-aut-sei=Wada en-aut-mei=Nozomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YasunakaTetsuya en-aut-sei=Yasunaka en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NishinaSohji en-aut-sei=Nishina en-aut-mei=Sohji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KorenagaMasaaki en-aut-sei=Korenaga en-aut-mei=Masaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HinoKeisuke en-aut-sei=Hino en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=FujiokaShin-ichi en-aut-sei=Fujioka en-aut-mei=Shin-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OsawaToshiya en-aut-sei=Osawa en-aut-mei=Toshiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ItoshimaTatsuya en-aut-sei=Itoshima en-aut-mei=Tatsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KawanakaMiwa en-aut-sei=Kawanaka en-aut-mei=Miwa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YamadaGotaro en-aut-sei=Yamada en-aut-mei=Gotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=KariyamaKazuya en-aut-sei=Kariyama en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=TakayamaHiroki en-aut-sei=Takayama en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KubotaJunichi en-aut-sei=Kubota en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=MorimotoYoichi en-aut-sei=Morimoto en-aut-mei=Yoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=YamashitaHaruhiko en-aut-sei=Yamashita en-aut-mei=Haruhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=TaniokaHiroaki en-aut-sei=Tanioka en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=NegoroYuji en-aut-sei=Negoro en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=ToshimoriJunichi en-aut-sei=Toshimori en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=KobashiHaruhiko en-aut-sei=Kobashi en-aut-mei=Haruhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=HiranoAtsushi en-aut-sei=Hirano en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= en-aut-name=ItanoYasuo en-aut-sei=Itano en-aut-mei=Yasuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=23 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=24 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=25 ORCID= affil-num=1 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Hepatology and Pancreatology, Kawasaki Medical University affil-num=5 en-affil= kn-affil=Department of Hepatology and Pancreatology, Kawasaki Medical University affil-num=6 en-affil= kn-affil=Department of Hepatology and Pancreatology, Kawasaki Medical University affil-num=7 en-affil= kn-affil=Department of Internal Medicine, Okayama Saiseikai General Hospital affil-num=8 en-affil= kn-affil=Department of Internal Medicine, Okayama Saiseikai General Hospital affil-num=9 en-affil= kn-affil=Department of Internal Medicine, Okayama Saiseikai General Hospital affil-num=10 en-affil= kn-affil=Department of Internal Medicine, Center for Liver Diseases, Kawasaki Hospital, Kawasaki Medical School affil-num=11 en-affil= kn-affil=Department of Internal Medicine, Center for Liver Diseases, Kawasaki Hospital, Kawasaki Medical School affil-num=12 en-affil= kn-affil=Department of Liver Disease Center, Okayama City Hospital affil-num=13 en-affil= kn-affil=Department of Gastroenterology, Tsuyama Central Hospital affil-num=14 en-affil= kn-affil=Department of Gastroenterology, Tsuyama Central Hospital affil-num=15 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Kurashiki Central Hospital affil-num=16 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=17 en-affil= kn-affil=Department of Gastroenterology, National Hospital Organization Okayama Medical Center affil-num=18 en-affil= kn-affil=Department of Internal Medicine, Okayama Rousai Hospital affil-num=19 en-affil= kn-affil=Department of Gastroenterology, Okayama Red Cross Hospital affil-num=20 en-affil= kn-affil=Department of Gastroenterology, Okayama Red Cross Hospital affil-num=21 en-affil= kn-affil=Department of Gastroenterology, Okayama Red Cross Hospital affil-num=22 en-affil= kn-affil=Department of Internal Medicine, National Hospital Organization Minami-Okayama Medical Center affil-num=23 en-affil= kn-affil=Department of Internal Medicine, Okayama Kyoritsu General Hospital affil-num=24 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=25 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=acute hepatitis kn-keyword=acute hepatitis en-keyword=hepatitis B virus kn-keyword=hepatitis B virus END start-ver=1.4 cd-journal=joma no-vol=156 cd-vols= no-issue= article-no= start-page=7 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140728 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical application of the Rey-Osterrieth Complex Figure Test for children with developmental disorders kn-title=発達障害をともなう子どもへのRey-Osterrieth 複雑図形検査の臨床応用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　本研究では，10 名の読みや書きなどの学習面に困難を抱える発達障害をともなう子ども にWechsler式知能検査およびRey-Osterrieth複雑図形検査（ROCF）を実施し，認知特性の 実態把握の過程におけるROCFの有用性を検討した。ROCFの記録には被検者の描画過程 をデータ化してパソコンに取り込むことのできるタッチペン （Inkling™） を用い，成績評価 には，描画の質的評価も含むBoston Qualitative Scoring System （BQSS） を用いた。 Wechsler式知能検査における知覚統合や知覚推理の下位検査の得点が良好であっても， ROCFにおいて構成力や描画過程に困難が少なからず認められ，これらは学習面における困 難の背景にある病態を反映したものと考えられた。また，本検査成績を検討する上で， BQSSの概要得点の1 つである組織構成，概要得点に含まれていないクラスター要素や細部 要素の配置の評価の重要性についても論じた。 en-copyright= kn-copyright= en-aut-name=SanadaSatoshi en-aut-sei=Sanada en-aut-mei=Satoshi kn-aut-name=眞田敏 kn-aut-sei=眞田 kn-aut-mei=敏 aut-affil-num=1 ORCID= en-aut-name=IkedaAoi en-aut-sei=Ikeda en-aut-mei=Aoi kn-aut-name=池田葵 kn-aut-sei=池田 kn-aut-mei=葵 aut-affil-num=2 ORCID= en-aut-name=Higa DiezMidory en-aut-sei=Higa Diez en-aut-mei=Midory kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KadoYoko en-aut-sei=Kado en-aut-mei=Yoko kn-aut-name=加戸陽子 kn-aut-sei=加戸 kn-aut-mei=陽子 aut-affil-num=4 ORCID= en-aut-name=OginoTatsuya en-aut-sei=Ogino en-aut-mei=Tatsuya kn-aut-name=荻野竜也 kn-aut-sei=荻野 kn-aut-mei=竜也 aut-affil-num=5 ORCID= en-aut-name=NakanoKousuke en-aut-sei=Nakano en-aut-mei=Kousuke kn-aut-name=中野広輔 kn-aut-sei=中野 kn-aut-mei=広輔 aut-affil-num=6 ORCID= en-aut-name=YamaneDaiki en-aut-sei=Yamane en-aut-mei=Daiki kn-aut-name=山根大輝 kn-aut-sei=山根 kn-aut-mei=大輝 aut-affil-num=7 ORCID= en-aut-name=YokouchiRie en-aut-sei=Yokouchi en-aut-mei=Rie kn-aut-name=横内理絵 kn-aut-sei=横内 kn-aut-mei=理絵 aut-affil-num=8 ORCID= en-aut-name=NounoShin en-aut-sei=Nouno en-aut-mei=Shin kn-aut-name=濃野信 kn-aut-sei=濃野 kn-aut-mei=信 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院教育学研究科発達支援学系 affil-num=2 en-affil= kn-affil=岡山大学大学院教育学研究科発達支援学系 affil-num=3 en-affil= kn-affil=岡山大学大学院自然科学研究科 affil-num=4 en-affil= kn-affil=関西大学文学部総合人文学科 affil-num=5 en-affil= kn-affil=中国学園大学子ども学部子ども学科 affil-num=6 en-affil= kn-affil=松山赤十字病院小児科 affil-num=7 en-affil= kn-affil=岡山大学大学院教育学研究科発達支援学系 affil-num=8 en-affil= kn-affil=岡山大学大学院教育学研究科発達支援学系 affil-num=9 en-affil= kn-affil=医療法人のうの小児科医院 en-keyword=Rey-Osterrieth複雑図形検査（ROCF） kn-keyword=Rey-Osterrieth複雑図形検査（ROCF） en-keyword=Boston Qualitative Scoring System (BQSS) kn-keyword=Boston Qualitative Scoring System (BQSS) en-keyword=Inkling™ kn-keyword=Inkling™ en-keyword=神経心理学的検査 kn-keyword=神経心理学的検査 en-keyword=発達障害 kn-keyword=発達障害 END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue=1 article-no= start-page=116 end-page=121 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=201101 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Serum levels of platelet-derived growth factor-BB and vascular endothelial growth factor as prognostic factors for patients with fulminant hepatic failure en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background and Aims: In animal models for acute liver injury, the administration of some angiogenic factors such as vascular endothelial growth factor (VEGF) and granulocyte-colony stimulating factor (G-CSF) are shown to reduce liver injury and improve liver proliferative capacity. The aim of the present study was to assess the role of angiogenic factors in fulminant hepatic failure (FHF). Methods: Serum levels of nine angiogenic factors (angiopoietin-2, follistatin, G-CSF, hepatocyte growth factor [HGF], interleukin-8, leptin, platelet-derived growth factor [PDGF]-BB, platelet endothelial cell adhesion molecule-1 and VEGF) were measured using the Bio-Plex Protein Array System in 30 patients, 17 of whom were diagnosed with FHF, 13 with acute hepatitis (AH), and 20 controls. Results: Serum levels of PDGF-BB and VEGF were lower in FHF patients than AH patients and controls (PDGF-BB; 2050 +/- 1572 pg/mL vs 4521 +/- 2419 pg/mL vs 8506 +/- 5500 pg/mL, VEGF; 39 +/- 38 pg/mL vs 144 +/- 122 pg/mL vs 205 +/- 121 pg/mL). By using univariate logistic regression models, serum levels of PDGF-BB and VEGF were associated with poor outcomes. Serum PDGF-BB levels were strongly correlated with serum VEGF levels (r = 0.70). Furthermore, serum PDGF-BB levels were significantly correlated with platelet counts (r = 0.79), PT activity (r = 0.37) and D.Bil/T.Bil ratio (r = 0.50), while serum VEGF levels were significantly correlated with platelet counts (r = 0.68) and PT activity (r = 0.38). Conclusions: We consider that serum levels of PDGF-BB and VEGF are worth investigating as biomarkers for predicting outcomes of FHF patients. en-copyright= kn-copyright= en-aut-name=TakayamaHiroki en-aut-sei=Takayama en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyakeYasuhiro en-aut-sei=Miyake en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ShirahaHidenori en-aut-sei=Shiraha en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KobashiHaruhiko en-aut-sei=Kobashi en-aut-mei=Haruhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=2 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=3 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=4 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=5 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=6 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=7 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=8 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol en-keyword=fulminant hepatic failure kn-keyword=fulminant hepatic failure en-keyword=hepatocyte growth factor kn-keyword=hepatocyte growth factor en-keyword=platelet-derived growth factor-BB kn-keyword=platelet-derived growth factor-BB en-keyword=prognostic factor kn-keyword=prognostic factor en-keyword=vascular endothelial growth factor kn-keyword=vascular endothelial growth factor END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=159 end-page=163 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Drug interaction (30. combination with therapeutic drugs for chronic pain) kn-title=薬物相互作用 (30―慢性疼痛治療薬の相互作用） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OgawaAtsushi en-aut-sei=Ogawa en-aut-mei=Atsushi kn-aut-name=小川敦 kn-aut-sei=小川 kn-aut-mei=敦 aut-affil-num=1 ORCID= en-aut-name=KitamuraYoshihisa en-aut-sei=Kitamura en-aut-mei=Yoshihisa kn-aut-name=北村佳久 kn-aut-sei=北村 kn-aut-mei=佳久 aut-affil-num=2 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name=千堂年昭 kn-aut-sei=千堂 kn-aut-mei=年昭 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=2 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=3 en-affil= kn-affil=岡山大学病院　薬剤部 END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=137 end-page=141 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of asymptomatic right-sided adult Bochdalek hernia presented incidentally with rectal tumor kn-title=直腸腫瘍を契機に発見された無症状の成人右側Bochdalek孔ヘルニアの１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　We encountered a patient with an adult Bochdalek hernia discovered asymptomatically. A 77-year-old Japanese woman visited a local clinic with chief complaints of melena and difficulty in defecation. Based on the results of the detailed examination in our hospital, she was diagnosed with a rectal gastrointestinal stromal tumor (GIST) with a concurrent asymptomatic adult right-sided Bochdalek hernia. Because the tumor was large, laparoscopic abdominoperineal rectal amputation was performed after systemic imatinib therapy. During the surgery, we found a right diaphragmatic defect more than 13cm in long dia., through which the right hepatic lobe, colon, and greater omentum had prolapsed into the right thoracic cavity. No visceral adhesions were noted. No hernia sac was observed. Adult Bochdalek hernia is a relatively rare condition, and only three (incidentally discovered) cases of asymptomatic Bochdalek hernia, including the present case, have been reported in Japan. Here we provide a case report for the patient, who was followed-up without hernia surgery, plus a review of the literature. en-copyright= kn-copyright= en-aut-name=KatoHiroshi en-aut-sei=Kato en-aut-mei=Hiroshi kn-aut-name=加藤大 kn-aut-sei=加藤 kn-aut-mei=大 aut-affil-num=1 ORCID= en-aut-name=OishiMasahiro en-aut-sei=Oishi en-aut-mei=Masahiro kn-aut-name=大石正博 kn-aut-sei=大石 kn-aut-mei=正博 aut-affil-num=2 ORCID= en-aut-name=KoderaMasahito en-aut-sei=Kodera en-aut-mei=Masahito kn-aut-name=小寺正人 kn-aut-sei=小寺 kn-aut-mei=正人 aut-affil-num=3 ORCID= en-aut-name=YamamuraMasao en-aut-sei=Yamamura en-aut-mei=Masao kn-aut-name=山村方夫 kn-aut-sei=山村 kn-aut-mei=方夫 aut-affil-num=4 ORCID= en-aut-name=IkedaHideaki en-aut-sei=Ikeda en-aut-mei=Hideaki kn-aut-name=池田秀明 kn-aut-sei=池田 kn-aut-mei=秀明 aut-affil-num=5 ORCID= en-aut-name=MizunoKenji en-aut-sei=Mizuno en-aut-mei=Kenji kn-aut-name=水野憲治 kn-aut-sei=水野 kn-aut-mei=憲治 aut-affil-num=6 ORCID= en-aut-name=YamashitaYutaka en-aut-sei=Yamashita en-aut-mei=Yutaka kn-aut-name=山下裕 kn-aut-sei=山下 kn-aut-mei=裕 aut-affil-num=7 ORCID= en-aut-name=SuzukiKazunori en-aut-sei=Suzuki en-aut-mei=Kazunori kn-aut-name=鈴木一則 kn-aut-sei=鈴木 kn-aut-mei=一則 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=鳥取市立病院　外科 affil-num=2 en-affil= kn-affil=鳥取市立病院　外科 affil-num=3 en-affil= kn-affil=鳥取市立病院　外科 affil-num=4 en-affil= kn-affil=鳥取市立病院　外科 affil-num=5 en-affil= kn-affil=鳥取市立病院　外科 affil-num=6 en-affil= kn-affil=鳥取市立病院　外科 affil-num=7 en-affil= kn-affil=鳥取市立病院　外科 affil-num=8 en-affil= kn-affil=鳥取生協病院　外科 en-keyword=成人Bochdalek孔ヘルニア（adult Bochdalek hernia） kn-keyword=成人Bochdalek孔ヘルニア（adult Bochdalek hernia） en-keyword=腹腔鏡下手術（laparoscopic surgery） kn-keyword=腹腔鏡下手術（laparoscopic surgery） END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=109 end-page=115 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Comprehensive treatment for gender identity disorder kn-title=性同一性障害に対する包括的治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NambaYuzaburo en-aut-sei=Namba en-aut-mei=Yuzaburo kn-aut-name=難波祐三郎 kn-aut-sei=難波 kn-aut-mei=祐三郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　ジェンダーセンター en-keyword=性同一性障害 kn-keyword=性同一性障害 en-keyword=包括的治療 kn-keyword=包括的治療 en-keyword=性別適合手術 kn-keyword=性別適合手術 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=水中探査用マンタロボットの推進制御に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaMasaaki en-aut-sei=Ikeda en-aut-mei=Masaaki kn-aut-name=池田将晃 kn-aut-sei=池田 kn-aut-mei=将晃 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺気腫 と 肺気腫合併喘息マウスモデルに対するロイコトリエン受容体拮抗剤の効果 kn-title=Effect of a Cysteinyl Leukotriene Receptor Antagonist on Experimental Emphysema and Asthma Combined with Emphysema en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaGenyo en-aut-sei=Ikeda en-aut-mei=Genyo kn-aut-name=池田元洋 kn-aut-sei=池田 kn-aut-mei=元洋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue=1 article-no= start-page=13 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case study on the rainfall distribution over the Japan Islands associated with the approach of Ty0423 in late October (Comparison with that for Ty0418) kn-title=2004年10月後半の台風23号に伴う日本列島での広域の降水（台風18号と比較して） en-subtitle= kn-subtitle= en-abstract= kn-abstract=Rainfall distribution in the Japan Islands associated with the approach of Typhoon No.23 around 20 October 2004 (referred to Ty0423, hereafter) showed considerably different features from those in late summer of this year. The present study examined the detailed rainfall features around the Japan Islands brought by Ty0423 and the atmospheric processes based on the operational observation data by the Japan Meteorological Agency (JMA), comparing with those in association with Ty0418 around 7 September 2004. During the stage when Ty0423 was approaching or landing on the western part of the Japan Islands, the areal mean precipitation from Kyushu to Kanto District attained much larger than that for Ty0418, with wider extension of the area with the large amount of precipitation. It is interesting that, although the intense rainfall was observed only at the upstream side of the mountain range from Kyushu to Honshu District for Ty0418 except for the area near its center, strong rainfall with 10~30 mm/h persisted in wider regions from the western to the eastern part of the Japan Islands, resulting in the considerably large total rainfall for Ty0423. As for the case for Ty0423, the surface front with stable frontal surface was located just to the east of the Ty0423 center just before its landing at the Japan Islands. Thus, the huge moisture inflow mainly in the eastern region from the typhoon center seems to be redistributed widely over the Japan Islands area associated with the large-scale convergence around the stable frontal surface. In late October, the colder air associated with the high pressure system in the eastern Siberia can cover the northern part of the Japan Sea area as the seasonal march. Such basic field might be favorable for sustaining the synoptic-scale front just around the southern coast of the Japan Islands, even when the strong southerly wind invades associated with the typhoon approach there. en-copyright= kn-copyright= en-aut-name=SatakeAi en-aut-sei=Satake en-aut-mei=Ai kn-aut-name=佐竹愛 kn-aut-sei=佐竹 kn-aut-mei=愛 aut-affil-num=1 ORCID= en-aut-name=KatoKuranoshin en-aut-sei=Kato en-aut-mei=Kuranoshin kn-aut-name=加藤内藏進 kn-aut-sei=加藤 kn-aut-mei=内藏進 aut-affil-num=2 ORCID= en-aut-name=MoriYoshinori en-aut-sei=Mori en-aut-mei=Yoshinori kn-aut-name=盛宣誠 kn-aut-sei=盛 kn-aut-mei=宣誠 aut-affil-num=3 ORCID= en-aut-name=GodaYasuhiro en-aut-sei=Goda en-aut-mei=Yasuhiro kn-aut-name=合田泰弘 kn-aut-sei=合田 kn-aut-mei=泰弘 aut-affil-num=4 ORCID= en-aut-name=IkedaShoichiro en-aut-sei=Ikeda en-aut-mei=Shoichiro kn-aut-name=池田祥一郎 kn-aut-sei=池田 kn-aut-mei=祥一郎 aut-affil-num=5 ORCID= en-aut-name=TsukamotoOsamu en-aut-sei=Tsukamoto en-aut-mei=Osamu kn-aut-name=塚本修 kn-aut-sei=塚本 kn-aut-mei=修 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil=岡山大学大学院教育学研究科 affil-num=3 en-affil= kn-affil= affil-num=4 en-affil= kn-affil= affil-num=5 en-affil= kn-affil=岡山大学大学院自然科学研究科 affil-num=6 en-affil= kn-affil=岡山大学大学院自然科学研究科 en-keyword=Ty0423 kn-keyword=Ty0423 en-keyword=Ty0418 kn-keyword=Ty0418 en-keyword=rainfall in Japan associated with a typhoon in mid-autumn kn-keyword=rainfall in Japan associated with a typhoon in mid-autumn en-keyword=effects of a typhoon on the synoptic climatology in Japan in October kn-keyword=effects of a typhoon on the synoptic climatology in Japan in October END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=1 article-no= start-page=17 end-page=22 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Impact of Comorbid Hepatic Steatosis on Treatment of Chronic Hepatitis C in Japanese Patients and the Relationship with Genetic Polymorphism of IL28B, PNPLA3 and LDL Receptor en-subtitle= kn-subtitle= en-abstract= kn-abstract=The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. Whether this holds true for Japanese patients, however, remains unresolved. The present study prospectively enrolled 226 Japanese patients with CHC, and investigated the impact of hepatic steatosis and its related SNPs, including rs8099917 of IL28B, rs738409 of PNPLA3, and rs14158 of LDL receptor, on outcomes of peg-interferon and ribavirin therapy. In multivariate logistic regression analysis, significant factors affecting the severity of hepatic steatosis were high body mass index and the minor alleles of IL28B SNP (p＝0.020 and 0.039, respectively). The risk alleles of PNPLA3 SNP also showed weak association (p＝0.059). Severe steatosis and the minor alleles of IL28B SNP were significantly associated with null or partial virological response in patients with HCV genotype 1, as were female gender, and low LDL cholesterol (p＝0.049, and ＜0.001, respectively). The SNP genotype of PNPLA3 and LDL receptor did not have a significant impact on therapeutic outcomes. With respect to the SNP sites examined, the SNP of PNPLA3 has a weak association with severe hepatic steatosis, but not with the outcome of interferon therapy. en-copyright= kn-copyright= en-aut-name=MoritouYuki en-aut-sei=Moritou en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=BabaNobuyuki en-aut-sei=Baba en-aut-mei=Nobuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakaguchiKouichi en-aut-sei=Takaguchi en-aut-mei=Kouichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SenohTomonori en-aut-sei=Senoh en-aut-mei=Tomonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NaganoTakuya en-aut-sei=Nagano en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakeuchiYasuto en-aut-sei=Takeuchi en-aut-mei=Yasuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YasunakaTetsuya en-aut-sei=Yasunaka en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OhnishiHideki en-aut-sei=Ohnishi en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MiyakeYasuhiro en-aut-sei=Miyake en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Health Service Center, Okayama University affil-num=4 en-affil= kn-affil=Department of Internal Medicine, Kagawa Prefectural Central Hospital affil-num=5 en-affil= kn-affil=Department of Internal Medicine, Kagawa Prefectural Central Hospital affil-num=6 en-affil= kn-affil=Department of Internal Medicine, Kagawa Prefectural Central Hospital affil-num=7 en-affil= kn-affil=Department of Internal Medicine, Kagawa Prefectural Central Hospital affil-num=8 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=11 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=12 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=13 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=14 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=hepatic steatosis kn-keyword=hepatic steatosis en-keyword=genetic polymorphism kn-keyword=genetic polymorphism en-keyword=interferon kn-keyword=interferon en-keyword=HCV kn-keyword=HCV END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=421 end-page=426 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=201204 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract=Radiofrequency ablation (RFA) is a standard therapy for the treatment of hepatocellular carcinoma (HCC) with 3 or fewer tumors of up to 3 cm (early-stage HCC); when RFA is unsuccessful or unfeasible, transcatheter arterial chemoembolization (TACE) has often been performed. However, little information about the outcome of TACE for early-stage HCC has been reported and it is hard to decide whether to perform additional treatment following TACE in these difficult conditions. The aim of this study was to determine the risk factors for local or intrahepatic distant recurrence after TACE in early-stage HCC. Among 1,560 newly diagnosed HCC patients who were admitted to Okayama University Hospital, 43 patients with early-stage HCC who received only TACE in at least one nodule were enrolled in this study. We analyzed the risk factors for local and distant recurrence by the Cox proportional hazard model. The local recurrence rates and intrahepatic distant recurrence rates at 3 months, 6 months, and 1 year were 18.6, 33.4, and 61.8%, and 2.8, 2.8, and 10.2%, respectively. Among 12 parameters examined as possible risk factors for recurrence, heterogeneous Lipiodol uptake (risk ratio 3.38; 95% confidence interval 1.14-10.60) and high serum des-gamma-carboxy prothrombin (DCP) (2.58; 1.03-7.14) were significantly correlated with local recurrence, and the presence of multiple tumors (10.64; 1.76-93.75) was significantly correlated with intrahepatic distant recurrence. Heterogeneous Lipiodol uptake, high serum DCP, and multiple tumors are risk factors for recurrence in patients with early-stage HCC who have undergone palliative TACE. en-copyright= kn-copyright= en-aut-name=KinugasaHideaki en-aut-sei=Kinugasa en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakeuchiYasuto en-aut-sei=Takeuchi en-aut-mei=Yasuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YasunakaTetsuya en-aut-sei=Yasunaka en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OnishiHideki en-aut-sei=Onishi en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakamuraShin-ichiro en-aut-sei=Nakamura en-aut-mei=Shin-ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShirahaHidenori en-aut-sei=Shiraha en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KuwakiKenji en-aut-sei=Kuwaki en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HagiharaHiroaki en-aut-sei=Hagihara en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MiyakeYasuhiro en-aut-sei=Miyake en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=2 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=3 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=4 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=5 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=6 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=7 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=8 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=9 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=10 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=11 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=12 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=13 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol en-keyword=Hepatocellular carcinoma kn-keyword=Hepatocellular carcinoma en-keyword=Small HCC kn-keyword=Small HCC en-keyword=TACE kn-keyword=TACE en-keyword=Early-stage HCC kn-keyword=Early-stage HCC END start-ver=1.4 cd-journal=joma no-vol=44 cd-vols= no-issue=9 article-no= start-page=1000 end-page=1006 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=200909 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Mortality rate of patients with asymptomatic primary biliary cirrhosis diagnosed at age 55 years or older is similar to that of the general population en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recent routine testing for liver function and anti-mitochondrial antibodies has increased the number of newly diagnosed patients with primary biliary cirrhosis (PBC). This study investigated the prognosis of asymptomatic PBC patients, focusing on age difference, to clarify its effect on the prognosis of PBC patients. The study was a systematic cohort analysis of 308 consecutive patients diagnosed with asymptomatic PBC. We compared prognosis between the elderly (55 years or older at the time of diagnosis) and the young patients (< 55 years). The mortality rate of the patients was also compared with that of an age- and gender-matched general population. The elderly patients showed a higher aspartate aminotransferase-to-platelet ratio, and lower alanine aminotransferase level than the young patients (P < 0.01 and P = 0.03, respectively). The two groups showed similar values for alkaline phosphatase and immunoglobulin M. Death in the young patients was more likely to be due to liver failure (71%), while the elderly were likely to die from other causes before the occurrence of liver failure (88%; P < 0.01), especially from malignancies (35%). The mortality rate of the elderly patients was not different from that of the age- and gender-matched general population (standardized mortality ratio, 1.1; 95% confidence interval, 0.6-1.7), although this rate was significantly higher than that of the young patients (P = 0.044). PBC often presents as more advanced disease in elderly patients than in the young. However, the mortality rate of the elderly patients is not different from that of an age- and gender-matched general population. en-copyright= kn-copyright= en-aut-name=KubotaJunichi en-aut-sei=Kubota en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TeradaRyo en-aut-sei=Terada en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KobashiHaruhiko en-aut-sei=Kobashi en-aut-mei=Haruhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujiokaShin-ichi en-aut-sei=Fujioka en-aut-mei=Shin-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkamotoRyoichi en-aut-sei=Okamoto en-aut-mei=Ryoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=BabaShinsuke en-aut-sei=Baba en-aut-mei=Shinsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MorimotoYouichi en-aut-sei=Morimoto en-aut-mei=Youichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=AndoMasaharu en-aut-sei=Ando en-aut-mei=Masaharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MakinoYasuhiro en-aut-sei=Makino en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TaniguchiHideaki en-aut-sei=Taniguchi en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YasunakaTetsuya en-aut-sei=Yasunaka en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=MiyakeYasuhiro en-aut-sei=Miyake en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=2 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=3 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=4 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=5 en-affil= kn-affil=Okayama Saiseikai Gen Hosp, Dept Internal Med affil-num=6 en-affil= kn-affil=Hiroshima City Hosp, Dept Internal Med affil-num=7 en-affil= kn-affil=Kagawa Prefectural Cent Hosp, Dept Internal Med affil-num=8 en-affil= kn-affil=Fukuyama City Hosp, Dept Internal Med affil-num=9 en-affil= kn-affil=Mitoyo Gen Hosp, Dept Internal Med affil-num=10 en-affil= kn-affil=Natl Hosp Org Iwakuni Clin Ctr, Dept Gastroenterol affil-num=11 en-affil= kn-affil=Sumitomo Besshi Hosp, Dept Internal Med affil-num=12 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=13 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=14 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=15 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol en-keyword=Primary biliary cirrhosis kn-keyword=Primary biliary cirrhosis en-keyword=Age difference kn-keyword=Age difference en-keyword=Mortality rate kn-keyword=Mortality rate END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=3 article-no= start-page=257 end-page=258 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Guidelines for treatment of bacterial meningitis kn-title=細菌性髄膜炎の治療ガイドライン en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaYoshio en-aut-sei=Ikeda en-aut-mei=Yoshio kn-aut-name=池田佳生 kn-aut-sei=池田 kn-aut-mei=佳生 aut-affil-num=1 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name=阿部康二 kn-aut-sei=阿部 kn-aut-mei=康二 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=群馬大学大学院医学系研究科　脳神経内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経内科学 END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=3 article-no= start-page=217 end-page=220 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Th2 cytokines increase kallikrein 7 expression and function in patients with atopic dermatitis kn-title=Th２サイトカインはアトピー性皮膚炎患者における カリクレイン７の発現と機能を増強する en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MorizaneShin en-aut-sei=Morizane en-aut-mei=Shin kn-aut-name=森実真 kn-aut-sei=森実 kn-aut-mei=真 aut-affil-num=1 ORCID= en-aut-name=YamasakiKenshi en-aut-sei=Yamasaki en-aut-mei=Kenshi kn-aut-name=山崎研志 kn-aut-sei=山崎 kn-aut-mei=研志 aut-affil-num=2 ORCID= en-aut-name=KajitaAi en-aut-sei=Kajita en-aut-mei=Ai kn-aut-name=梶田藍 kn-aut-sei=梶田 kn-aut-mei=藍 aut-affil-num=3 ORCID= en-aut-name=IkedaKazuko en-aut-sei=Ikeda en-aut-mei=Kazuko kn-aut-name=池田佳寿子 kn-aut-sei=池田 kn-aut-mei=佳寿子 aut-affil-num=4 ORCID= en-aut-name=ZhanMaosheng en-aut-sei=Zhan en-aut-mei=Maosheng kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AoyamaYumi en-aut-sei=Aoyama en-aut-mei=Yumi kn-aut-name=青山裕美 kn-aut-sei=青山 kn-aut-mei=裕美 aut-affil-num=6 ORCID= en-aut-name=Richard L Gallo en-aut-sei=Richard L Gallo en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IwatsukiKeiji en-aut-sei=Iwatsuki en-aut-mei=Keiji kn-aut-name=岩月啓氏 kn-aut-sei=岩月 kn-aut-mei=啓氏 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　皮膚科学 affil-num=2 en-affil= kn-affil=東北大学大学院医学系研究科　皮膚科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　皮膚科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　皮膚科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　皮膚科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　皮膚科学 affil-num=7 en-affil= kn-affil=米国カリフォルニア大学サンディエゴ校医学部　皮膚科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　皮膚科学 en-keyword=アトピー性皮膚炎 kn-keyword=アトピー性皮膚炎 en-keyword=Th２サイトカイン kn-keyword=Th２サイトカイン en-keyword=カリクレイン kn-keyword=カリクレイン en-keyword=表皮角化細胞 kn-keyword=表皮角化細胞 END start-ver=1.4 cd-journal=joma no-vol=43 cd-vols= no-issue=10 article-no= start-page=1078 end-page=1092 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Serum oxidative-anti-oxidative stress balance is dysregulated in patients with hepatitis C virus-related hepatocellular carcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract=Aim Oxidative stress is associated with progression of chronic liver disease (CLD). This association is best established in chronic hepatitis C. However, the anti-oxidative state is not well characterized. The objective of the present study was to investigate the balance of oxidative and anti-oxidative stress in CLD patients. Methods We recruited a study population of 208 patients, including healthy volunteers (HV; n = 15), patients with hepatitis B virus (HBV)-related CLD without or with hepatocellular carcinoma (HBV-non-HCC, n = 25, and HBV-HCC, n = 50, respectively), and patients with hepatitis C virus (HCV)-related CLD without or with HCC (HCV-non-HCC, n = 49, and HCV-HCC, n = 69, respectively). Serum levels of reactive oxygen metabolites (ROM) and anti-oxidative markers (OXY-adsorbent test; OXY) were determined, and the balance of these values was used as the oxidative index. Correlations among ROM, OXY, oxidative index and clinical characteristics were investigated. Results Patients with CLD exhibited elevated ROM and oxidative index compared to HV. Among patients with CLD, HCV positive status correlated with increased ROM. In CLD, HCV-HCC patients exhibited the highest ROM levels. Among HCV-related CLD patients, lower OXY correlated with HCC positive status, but was recovered by eradication of HCC. In HCV-HCC, lower OXY correlated with high PT-INR. Conclusion HCV positive CLD patients displayed higher oxidative stress and HCV-HCC patients displayed lower anti-oxidative state. Anti-oxidative state depression was associated with liver reservoir-related data in HCV-HCC and could be reversed with HCC eradication. en-copyright= kn-copyright= en-aut-name=NishimuraMamoru en-aut-sei=Nishimura en-aut-mei=Mamoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TamakiNaofumi en-aut-sei=Tamaki en-aut-mei=Naofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MaruyamaTakayuki en-aut-sei=Maruyama en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OnishiHideki en-aut-sei=Onishi en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KobayashiSayo en-aut-sei=Kobayashi en-aut-mei=Sayo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YasunakaTetsuya en-aut-sei=Yasunaka en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KoikeKazuko en-aut-sei=Koike en-aut-mei=Kazuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HagiharaHiroaki en-aut-sei=Hagihara en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KuwakiKenji en-aut-sei=Kuwaki en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NakamuraShinichiro en-aut-sei=Nakamura en-aut-mei=Shinichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=TomofujiTakaaki en-aut-sei=Tomofuji en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=MoritaManabu en-aut-sei=Morita en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= affil-num=1 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Preventive Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School affil-num=4 en-affil= kn-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=11 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=12 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=13 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=14 en-affil= kn-affil=Health Service Center, Okayama University affil-num=15 en-affil= kn-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=16 en-affil= kn-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=17 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=anti-oxidant kn-keyword=anti-oxidant en-keyword=chronic hepatitis C kn-keyword=chronic hepatitis C en-keyword=hepatocellular carcinoma kn-keyword=hepatocellular carcinoma en-keyword=oxidative stress kn-keyword=oxidative stress END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue= article-no= start-page=33 end-page=41 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20061028 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=2006中学校数学｢数量関係｣の学力診断調査の結果と概要 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=黒崎東洋郎 kn-aut-sei=黒崎 kn-aut-mei=東洋郎 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高橋敏雄 kn-aut-sei=高橋 kn-aut-mei=敏雄 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=洲脇史朗 kn-aut-sei=洲脇 kn-aut-mei=史朗 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=秋山真 kn-aut-sei=秋山 kn-aut-mei=真 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=木村善生 kn-aut-sei=木村 kn-aut-mei=善生 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=宇津見雅英 kn-aut-sei=宇津見 kn-aut-mei=雅英 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平野圭一 kn-aut-sei=平野 kn-aut-mei=圭一 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=池田智裕 kn-aut-sei=池田 kn-aut-mei=智裕 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡部初江 kn-aut-sei=岡部 kn-aut-mei=初江 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学教育学部 affil-num=2 en-affil= kn-affil=岡山大学教育学部 affil-num=3 en-affil= kn-affil=岡山理科大学 affil-num=4 en-affil= kn-affil=岡山市立東山中学校 affil-num=5 en-affil= kn-affil=岡山大学教育学部附属中学校 affil-num=6 en-affil= kn-affil=瀬戸内市立邑久中学校 affil-num=7 en-affil= kn-affil=岡山市立竜操中学校 affil-num=8 en-affil= kn-affil=岡山市立岡北中学校 affil-num=9 en-affil= kn-affil=岡山県教育センター・教育情報センター END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue= article-no= start-page=27 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20061028 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=2006 中学校数学「数量関係」の学力診断調査 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=黒崎東洋郎 kn-aut-sei=黒崎 kn-aut-mei=東洋郎 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高橋敏雄 kn-aut-sei=高橋 kn-aut-mei=敏雄 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=洲脇史朗 kn-aut-sei=洲脇 kn-aut-mei=史朗 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=秋山真 kn-aut-sei=秋山 kn-aut-mei=真 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=木村善生 kn-aut-sei=木村 kn-aut-mei=善生 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=宇津見雅英 kn-aut-sei=宇津見 kn-aut-mei=雅英 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平野圭一 kn-aut-sei=平野 kn-aut-mei=圭一 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=池田智裕 kn-aut-sei=池田 kn-aut-mei=智裕 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡部初江 kn-aut-sei=岡部 kn-aut-mei=初江 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学教育学部 affil-num=2 en-affil= kn-affil=岡山大学教育学部 affil-num=3 en-affil= kn-affil=岡山理科大学 affil-num=4 en-affil= kn-affil=岡山市立東山中学校 affil-num=5 en-affil= kn-affil=岡山大学教育学部附属中学校 affil-num=6 en-affil= kn-affil=瀬戸内市立邑久中学校 affil-num=7 en-affil= kn-affil=岡山市立竜操中学校 affil-num=8 en-affil= kn-affil=岡山市立岡北中学校 affil-num=9 en-affil= kn-affil=岡山県教育センター・教育情報センター END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=2 article-no= start-page=153 end-page=157 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Guidelines for management of severe sepsis and septic shock kn-title=敗血症ガイドライン en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NishieHiroyuki en-aut-sei=Nishie en-aut-mei=Hiroyuki kn-aut-name=西江宏行 kn-aut-sei=西江 kn-aut-mei=宏行 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院 麻酔科蘇生科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=マウスのCD49f陽性顎下腺細胞を用いた唾液腺再生に関与する因子の探求 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaAtsushi en-aut-sei=Ikeda en-aut-mei=Atsushi kn-aut-name=池田淳史 kn-aut-sei=池田 kn-aut-mei=淳史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=12 article-no= start-page=1187 end-page=1195 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=201212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clinical utility of serum fucosylated hemopexin in Japanese patients with hepatocellular carcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract=Aim: Hepatocellular carcinoma (HCC) is a common clinical problem all over the world. Fucosylated hemopexin (Fuc-Hpx) is a newly reported glycoprotein for the diagnosis of HCC, however, its clinical implications are unclear. The aim of this study was to elucidate the clinical utility of Fuc-Hpx in Japanese patients with HCC. Methods: The sera from 331 HCC patients, 45 with liver cirrhosis (LC), 85 with chronic hepatitis (CH) and 22 healthy people were examined for the expression of Fuc-Hpx; the level was compared with clinical parameters as well as hemopexin (Hpx) expression. The expressions of Fuc-Hpx in 12 HCC tissues and corresponding adjacent non-cancerous liver tissues were also examined. Results: No correlation was observed between Hpx and Fuc-Hpx level. The median Fuc-Hpx levels in healthy people and CH, LC and HCC patients were 3.8, 3.7, 6.1 and 7.6 AU/mL, respectively (CH vs LC, P = 0.002; CH vs HCC, P < 0.001; LC vs HCC, P = 0.02). Multivariate analysis revealed that low albumin, low prothrombin time and the presence of HCC were significantly correlated with high Fuc-Hpx (P = 0.013, =0.001 and <0.001, respectively). Among the HCC patients, albumin was correlated with high Fuc-Hpx; however, none of the tumor factors, such as tumor size, tumor number and tumor stage, was correlated with Fuc-Hpx level. The expression of Fuc-Hpx in cancer tissue was not different from that in non-cancerous tissue. Conclusion: Fuc-Hpx is a valuable biomarker for HCC but it might be a marker for hypercarcinogenic liver rather than a marker for tumor-bearing liver. en-copyright= kn-copyright= en-aut-name=KobayashiSayo en-aut-sei=Kobayashi en-aut-mei=Sayo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KinugasaHideaki en-aut-sei=Kinugasa en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakeuchiYasuto en-aut-sei=Takeuchi en-aut-mei=Yasuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TomodaTakeshi en-aut-sei=Tomoda en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyaharaKoji en-aut-sei=Miyahara en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HagiharaHiroaki en-aut-sei=Hagihara en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KuwakiKenji en-aut-sei=Kuwaki en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OnishiHideki en-aut-sei=Onishi en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NakamuraShinichiro en-aut-sei=Nakamura en-aut-mei=Shinichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MiyakeYasuhiro en-aut-sei=Miyake en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=ShirahaHidenori en-aut-sei=Shiraha en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol affil-num=2 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Hepatol affil-num=3 en-affil= kn-affil= affil-num=4 en-affil= kn-affil= affil-num=5 en-affil= kn-affil= affil-num=6 en-affil= kn-affil= affil-num=7 en-affil= kn-affil= affil-num=8 en-affil= kn-affil= affil-num=9 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Hepatol affil-num=10 en-affil= kn-affil= affil-num=11 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Hepatol affil-num=12 en-affil= kn-affil= affil-num=13 en-affil= kn-affil= affil-num=14 en-affil= kn-affil= affil-num=15 en-affil= kn-affil= en-keyword=biomarker kn-keyword=biomarker en-keyword=fucosylated hemopexin kn-keyword=fucosylated hemopexin en-keyword=glycosylation kn-keyword=glycosylation en-keyword=hepatocellular carcinoma kn-keyword=hepatocellular carcinoma en-keyword=hypercarcinogenicity kn-keyword=hypercarcinogenicity END start-ver=1.4 cd-journal=joma no-vol=430 cd-vols= no-issue=2 article-no= start-page=592 end-page=597 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130111 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=PML tumor suppressor protein is required for HCV production en-subtitle= kn-subtitle= en-abstract= kn-abstract=PML tumor suppressor protein, which forms discrete nuclear structures termed PML-nuclear bodies, has been associated with several cellular functions, including cell proliferation, apoptosis and antiviral defense. Recently, it was reported that the HCV core protein colocalizes with PML in PML-NBs and abrogates the PML function through interaction with PML. However, role(s) of PML in HCV life cycle is unknown. To test whether or not PML affects HCV life cycle, we examined the level of secreted HCV core and the infectivity of HCV in the culture supernatants as well as the level of HCV RNA in HuH-7-derived RSc cells, in which HCV-JFH1 can infect and efficiently replicate, stably expressing short hairpin RNA targeted to PML. In this context, the level of secreted HCV core and the infectivity in the supernatants from PML knockdown cells was remarkably reduced, whereas the level of HCV RNA in the PML knockdown cells was not significantly affected in spite of very effective knockdown of PML. In fact, we showed that PML is unrelated to HCV RNA replication using the subgenomic HCV-JFH1 replicon RNA, JRN/3-5B. Furthermore, the infectivity of HCV-like particle in the culture supernatants was significantly reduced in PML knockdown JRN/3-5B cells expressing core to NS2 coding region of HCV-JFH1 genome using the trans-packaging system. Finally, we also demonstrated that INI1 and DDX5, the PML-related proteins, are involved in HCV production. Taken together, these findings suggest that PML is required for HCV production. en-copyright= kn-copyright= en-aut-name=KurokiMisao en-aut-sei=Kuroki en-aut-mei=Misao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AriumiYasuo en-aut-sei=Ariumi en-aut-mei=Yasuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HijikataMakoto en-aut-sei=Hijikata en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IkedaMasanori en-aut-sei=Ikeda en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=DansakoHiromichi en-aut-sei=Dansako en-aut-mei=Hiromichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=WakitaTakaji en-aut-sei=Wakita en-aut-mei=Takaji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShimotohnoKunitada en-aut-sei=Shimotohno en-aut-mei=Kunitada kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KatoNobuyuki en-aut-sei=Kato en-aut-mei=Nobuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Dept Tumor Virol, Sch Med Dent & Pharmaceut Sci affil-num=2 en-affil= kn-affil=Okayama Univ, Dept Tumor Virol, Sch Med Dent & Pharmaceut Sci affil-num=3 en-affil= kn-affil=Kyoto Univ, Dept Viral Oncol, Inst Virus Res affil-num=4 en-affil= kn-affil=Okayama Univ, Dept Tumor Virol, Sch Med Dent & Pharmaceut Sci affil-num=5 en-affil= kn-affil=Okayama Univ, Dept Tumor Virol, Sch Med Dent & Pharmaceut Sci affil-num=6 en-affil= kn-affil=Natl Inst Infect Dis, Dept Virol 2 affil-num=7 en-affil= kn-affil=Natl Ctr Global Hlth & Med, Res Ctr Hepatitis & Immunol affil-num=8 en-affil= kn-affil=Okayama Univ, Dept Tumor Virol, Sch Med Dent & Pharmaceut Sci en-keyword=Hepatitis C virus kn-keyword=Hepatitis C virus en-keyword=PML kn-keyword=PML en-keyword=INI1 kn-keyword=INI1 en-keyword=DDX5 kn-keyword=DDX5 en-keyword=Tumor suppressor kn-keyword=Tumor suppressor en-keyword=Lipid droplet kn-keyword=Lipid droplet END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue=8 article-no= start-page=1107 end-page=1114 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20101116 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=In vivo imaging of autophagy in a mouse stroke model en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recent studies have suggested that autophagy is involved in a neural death pathway following cerebral ischemia. In vivo detection of autophagy could be important for evaluating ischemic neural cell damage for human stroke patients. Using novel green fluorescent protein (GFP)-fused microtubule-associated protein 1 light chain 3 (LC3) transgenic (Tg) mice, in vivo imaging of autophagy was performed at 1, 3 and 6 d after 60 min transient middle cerebral artery occlusion (tMCAO). Ex vivo imaging of autophagy, testing of the autophagy inhibitor 3-methyladenine (3-MA), estern blot analysis, immunohistochemistry, terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling (TUNEL) and fluorescent analyses were performed on brain sections following tMCAO. In vivo fluorescent signals were detected above the ischemic hemisphere through the skull bone at 1, 3 and 6 d after tMCAO, with a peak at 1 d. Similar results were obtained with ex vivo fluorescence imaging. western blot analysis revealed maximum LC3-I and LC3-II expression at 1 d after tMCAO and fluorescence immunohistochemistry demonstrated that GFP-LC3-positive cells were primarily neuronal, not astroglial or microglial, cells. The number of GFP-LC3/TUNEL double-positive cells was greater in the peri-ischemic area than in the core. These results provided evidence of in vivo autophagy detection, with a peak at 1 d, in a live animal model following cerebral ischemia. This novel technique could be valuable for monitoring autophagic processes in vivo in live stroke patients, as well as for clarifying the detailed role of autophagy in the ischemic brain, as well as in other neurological diseases. en-copyright= kn-copyright= en-aut-name=TianFengFeng en-aut-sei=Tian en-aut-mei=FengFeng kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=DeguchiKentaro en-aut-sei=Deguchi en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MorimotoNobutoshi en-aut-sei=Morimoto en-aut-mei=Nobutoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ZhangXuemei en-aut-sei=Zhang en-aut-mei=Xuemei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=LiuNing en-aut-sei=Liu en-aut-mei=Ning kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=IkedaYoshio en-aut-sei=Ikeda en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MatsuuraTohru en-aut-sei=Matsuura en-aut-mei=Tohru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=2 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=3 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=4 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=5 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=6 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=7 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=8 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=9 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=10 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=11 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci en-keyword=autophagy kn-keyword=autophagy en-keyword=apoptosis kn-keyword=apoptosis en-keyword=GFP-LC3 Tg mice kn-keyword=GFP-LC3 Tg mice en-keyword=in vivo imaging kn-keyword=in vivo imaging en-keyword=tMCAO kn-keyword=tMCAO END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=1 article-no= start-page=35 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An epidemiologically rare case of Vibrio vulnificus infection that occurred in October in an inland city of Japan kn-title=内陸地津山で発症した季節外れのVibrio vulnificus感染症 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 68-year-old man with alcohol addiction, who lived in the suburbs of Tsuyama, an inland city located in northeast Okayama prefecture, was transported to the emergency unit of the Tsuyama Central Hospital in a state of cardiopulmonary arrest (CPA). Despite rigorous systemic investigation and treatment, the patient died 2 hours after arrival. After his death, Vibrio vulnificus was isolated from his blood culture. 　Vibrio vulnificus causes fatal infection in humans, usually only in areas located close to the sea where appropriate temperature and suitable salt concentration for its growth are available. Therefore, its occurrence is epidemiologically restricted ; in Japan, the western coastal areas, especially in summers, are reported to be the high-risk regions. This is a rare case because it occurred in a city approximately 50 kilometers from both the Sea of Japan and the Pacific coast of Okayama, and at the end of October in 2011. Economic development and distribution systems have made it possible to transport various food products from coastal areas or abroad to any place in a short time, such that these infections can potentially develop in areas other than expected. We should be aware of the increasing risk of Vibrio vulnificus infection during any season and at any place, especially in patients with abnormal liver function. en-copyright= kn-copyright= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name=萩谷英大 kn-aut-sei=萩谷 kn-aut-mei=英大 aut-affil-num=1 ORCID= en-aut-name=ShiotaSumiko en-aut-sei=Shiota en-aut-mei=Sumiko kn-aut-name=塩田澄子 kn-aut-sei=塩田 kn-aut-mei=澄子 aut-affil-num=2 ORCID= en-aut-name=MiyoshiShin-ichi en-aut-sei=Miyoshi en-aut-mei=Shin-ichi kn-aut-name=三好伸一 kn-aut-sei=三好 kn-aut-mei=伸一 aut-affil-num=3 ORCID= en-aut-name=KuroeYasutoshi en-aut-sei=Kuroe en-aut-mei=Yasutoshi kn-aut-name=黒江泰利 kn-aut-sei=黒江 kn-aut-mei=泰利 aut-affil-num=4 ORCID= en-aut-name=NojimaHiroyoshi en-aut-sei=Nojima en-aut-mei=Hiroyoshi kn-aut-name=野島宏悦 kn-aut-sei=野島 kn-aut-mei=宏悦 aut-affil-num=5 ORCID= en-aut-name=OtaniShinkichi en-aut-sei=Otani en-aut-mei=Shinkichi kn-aut-name=大谷晋吉 kn-aut-sei=大谷 kn-aut-mei=晋吉 aut-affil-num=6 ORCID= en-aut-name=SugiyamaJunichi en-aut-sei=Sugiyama en-aut-mei=Junichi kn-aut-name=杉山淳一 kn-aut-sei=杉山 kn-aut-mei=淳一 aut-affil-num=7 ORCID= en-aut-name=NaitoHiromichi en-aut-sei=Naito en-aut-mei=Hiromichi kn-aut-name=内藤宏道 kn-aut-sei=内藤 kn-aut-mei=宏道 aut-affil-num=8 ORCID= en-aut-name=KawanishiSusumu en-aut-sei=Kawanishi en-aut-mei=Susumu kn-aut-name=川西進 kn-aut-sei=川西 kn-aut-mei=進 aut-affil-num=9 ORCID= en-aut-name=HagiokaShingo en-aut-sei=Hagioka en-aut-mei=Shingo kn-aut-name=萩岡信吾 kn-aut-sei=萩岡 kn-aut-mei=信吾 aut-affil-num=10 ORCID= en-aut-name=MorimotoNaoki en-aut-sei=Morimoto en-aut-mei=Naoki kn-aut-name=森本直樹 kn-aut-sei=森本 kn-aut-mei=直樹 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=2 en-affil= kn-affil=就実大学薬学部　病原微生物学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　衛生微生物化学 affil-num=4 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=5 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=6 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=7 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=8 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=9 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=10 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=11 en-affil= kn-affil=津山中央病院　救命救急センター en-keyword=Vibrio vulnificus kn-keyword=Vibrio vulnificus END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110311 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=津島岡大道跡 20　―第32次調査―　（教育学部剣道場新営工事に伴う発掘調査） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=池田晋 kn-aut-sei=池田 kn-aut-mei=晋 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=能城修一 kn-aut-sei=能城 kn-aut-mei=修一 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=2009 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Bulletin of Archaelogical Research Center Okayama University 2009 kn-title=岡山大学埋蔵文化財調査研究センター紀要2009 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=池田晋 kn-aut-sei=池田 kn-aut-mei=晋 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岩崎志保 kn-aut-sei=岩崎 kn-aut-mei=志保 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=野崎貴博 kn-aut-sei=野崎 kn-aut-mei=貴博 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=光本順 kn-aut-sei=光本 kn-aut-mei=順 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤雄一郎 kn-aut-sei=工藤 kn-aut-mei=雄一郎 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山本悦世 kn-aut-sei=山本 kn-aut-mei=悦世 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil= affil-num=6 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=1 article-no= start-page=59 end-page=62 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Gastric aberrant pancreas with acute pancreatitis treated with surgery kn-title=膵炎を伴った胃異所性膵の1切除例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We experienced a case of gastric aberrant pancreas with acute pancreatitis. The patient was a 42-year-old man. He was referred to our hospital because of epigastric pain. A CT scan and endoscopic examination revealed a gastric submucosal tumor with inflammation. His serum amylase level was high at 222 IU/l. Endoscopic ultrasonography revealed a hypoechoic mass lesion, 3 cm in diameter, at the body of his stomach. Endoscopic ultrasoundscopy-guided fine needle aspiration was performed. Pathological examination showed pancreatic tissue. So, he underwent partial gastrectomy due to gastric aberrant pancreas with pancreatitis. There are very few cases of gastric aberrant pancreas with pancreatitis on record. en-copyright= kn-copyright= en-aut-name=ShinouraSusumu en-aut-sei=Shinoura en-aut-mei=Susumu kn-aut-name=篠浦先 kn-aut-sei=篠浦 kn-aut-mei=先 aut-affil-num=1 ORCID= en-aut-name=YagiTakahito en-aut-sei=Yagi en-aut-mei=Takahito kn-aut-name=八木孝仁 kn-aut-sei=八木 kn-aut-mei=孝仁 aut-affil-num=2 ORCID= en-aut-name=SadamoriHiroshi en-aut-sei=Sadamori en-aut-mei=Hiroshi kn-aut-name=貞森裕 kn-aut-sei=貞森 kn-aut-mei=裕 aut-affil-num=3 ORCID= en-aut-name=MatsudaHiroaki en-aut-sei=Matsuda en-aut-mei=Hiroaki kn-aut-name=松田浩明 kn-aut-sei=松田 kn-aut-mei=浩明 aut-affil-num=4 ORCID= en-aut-name=UmedaYuzo en-aut-sei=Umeda en-aut-mei=Yuzo kn-aut-name=楳田祐三 kn-aut-sei=楳田 kn-aut-mei=祐三 aut-affil-num=5 ORCID= en-aut-name=YoshidaRyuichi en-aut-sei=Yoshida en-aut-mei=Ryuichi kn-aut-name=吉田龍一 kn-aut-sei=吉田 kn-aut-mei=龍一 aut-affil-num=6 ORCID= en-aut-name=SatohDaisuke en-aut-sei=Satoh en-aut-mei=Daisuke kn-aut-name=佐藤太佑 kn-aut-sei=佐藤 kn-aut-mei=太佑 aut-affil-num=7 ORCID= en-aut-name=UtsumiMasashi en-aut-sei=Utsumi en-aut-mei=Masashi kn-aut-name=内海方嗣 kn-aut-sei=内海 kn-aut-mei=方嗣 aut-affil-num=8 ORCID= en-aut-name=YokomichiNaosuke en-aut-sei=Yokomichi en-aut-mei=Naosuke kn-aut-name=横道直佑 kn-aut-sei=横道 kn-aut-mei=直佑 aut-affil-num=9 ORCID= en-aut-name=KuiseTakashi en-aut-sei=Kuise en-aut-mei=Takashi kn-aut-name=杭瀬崇 kn-aut-sei=杭瀬 kn-aut-mei=崇 aut-affil-num=10 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 en-keyword=異所性膵 (ectopic pancreas) kn-keyword=異所性膵 (ectopic pancreas) en-keyword=迷入膵 (aberrant pancreas) kn-keyword=迷入膵 (aberrant pancreas) en-keyword=粘膜下腫瘍 (submucosal tumor) kn-keyword=粘膜下腫瘍 (submucosal tumor) en-keyword=急性膵炎 (acute pancreatitis) kn-keyword=急性膵炎 (acute pancreatitis) en-keyword=胃 (stomach) kn-keyword=胃 (stomach) END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue=338 article-no= start-page=269 end-page=295 dt-received= dt-revised= dt-accepted= dt-pub-year=1918 dt-pub=19180331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=天然營養兒ニ襲來スル一種特有ノ神經症状ヲ具備スル所ノ一新疾患ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=池田嘉一郎 kn-aut-sei=池田 kn-aut-mei=嘉一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=大連醫院小兒科 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=371 article-no= start-page=646 end-page=666 dt-received= dt-revised= dt-accepted= dt-pub-year=1920 dt-pub=19201231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=所謂人乳中毒症及ビ乳兒脚氣ノ異同問題ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=(一)所謂人乳中毒症ニ於ケル精紳症状ハ、輕症ナルモノニ於テハ、一過性ノ興奮性充進竝ニ嗜眠状態ヲ呈スルニ過ギザルモ、重症ナルモノニ於テハ、更ニ進ミテ意識溷濁乃至無慾状顔貌ヲ呈シ、周圍ノ事情ニ對スル識別力ヲ失ヒ笑ハズ泣カズ、眼付曇ヨリシ、時トシテ舞踏病樣不隨意運動乃至不明ノ言ラ發ス、カク特異ナル精紳症状ヲ呈スルハ神經申樞ニ何等カノ病變ノ存スルモノト考ヘザルベカラズ、余ハカカル患者ニ遭遇スル毎ニ勉メテ腰椎穿刺ヲ行ヒ腦脊髓液ノ性状ヲ檢シタルニ、ソノ外觀、比重、糖反應、蛋白量、蜘蛛網状物形成ノ有無等ノ關係ハ、多クハ健康者ノモノト差異ヲ認ムルコト能ハザリシモ、「グロブリン」反應及ビ細胞數ニ於テ輕微ノ變化ノ存スルヲ認メタリ、即チ「グロブリン」反應中、ノンネーアツペルト氏反應竝ニパンヂー氏反應ハ多クハ陰性(時トシテ弱陽性ナルコトアリ)ナルモ野口氏反應ハ毎常弱陽性ヲ示セリ、而シテ淋巴球ノ數ハ通常ナルカ或ハ僅ニ増加セリ、即チ輕度ノ漿液性腦膜炎ノ腦脊髓液ニ相類似ス、カカル腦脊髓液ノ變化ハ唐澤博士ノ報告セル軟腦膜ニ於ケル解剖的變化ト相符合ス。(二)臨牀上ニ於ケル所謂人乳中毒症ト乳兒脚氣トノ主要ナル區別點ハ、伊東博士ニ依レバ血行器症状竝ニ精神症状ノ有無ニ存ス、然レドモ血行器症状ハ兩疾患ヲ鑑別スルニ向ツテ爾カク重要ナル資料トナスヲ得ズ、蓋シ血行器症状ハ乳兒脚氣ニ於ケル必要ナル症状ノ一ツナルモ而モ之ヲ伴ハザルモノ稀ナラズ、又所謂人乳中毒症ニ於テモ血行器症状ハ必ラズ缺如スベキモノニアラザルガ故ナリ、況ンヤ症例(三)ニ於ケルガ如ク、所謂人乳中毒症ニ於テ其ノ經渦中ニ突然衝心症状ヲ表ハシタル事實アルエ於テオヤ。精神症状ノ有無ニ至リテハ、吾人ハ兩疾患ニ於ケル最モ顯著ナル差異タルヲ是認セザルベカラズ、然レドモ大人脚氣ニ於テ稀ニ精神症状ヲ伴フコトアルコト竝ニ余ノ實驗例ノ如ク幼兒脚氣ニ於テ躁暴狂状乃至昏迷ヲ呈シ、而モ軟腦膜ノ病理解剖的所見ニ於テ所謂人乳中毒症ト殆ド同樣ナル病變ヲ呈セルコトアル事實ヨリ推考スル時ハ、乳兒脚氣ニアリテモ亦精神症状ノ表ハルルコトアリテ可ナル理ナリ。(三)所謂人乳中毒症ト母體脚氣トハ甚ダ密接ナル關係ヲ有スルハ余ノ統計的觀察ニ依リテ明カナリ、余ノ症例(四)及ピ(五)ハ正シクコノ事實ヲ立證セルモスト云フヲ得ベシ、即チ余ノ症例ハ哺乳ノ時期ヲ異ニスルモ、脚氣ヲ有スル同一母體ノ乳汁ヲ哺乳シタルニ依リテ、第四子ハ乳兒脚氣ヲ惹起シ、第五子ハ所謂人乳中毒症ヲ惹起セルモノトス、カカル事實ハ、所謂人乳中毒症ハ其ノ本態ニ於テ乳兒脚氣症ト同一ナルモノニアラズヤトノ疑念ヲ益々吾人ニ抱カシム。(四)以上ノ事實ヲ綜合スル時ハ、所謂人乳中毒症ハ其ノ本態ニ於テ乳兒脚氣ト同一上ニ立ツベキ疾患ニシテ、詳言セバ乳兒脚氣ノ一異型ト見做スベキモノナリト信ズ、余思ヘラク、乳兒脚氣ハ脚氣毒素ガ母體ノ乳汁ヲ介シテ小兒ニ移行スルニ依リテ起ル一種ノ中毒症ニ外ナラズ、而シテ臨牀上ニ於テ一方ニハ專ラ心臓機能ヲ障碍スル衝心型アリ又他方ニ血行器症状ヲ件ハズシテ専ラ末梢神經ヲ侵ス所ノ麻痺型ナルモノアリ、コレ等ノ事實ヨリ考フル時ハ脚氣毒素ガ主トシテ心臓ヲ侵ス時ハ衝心型トナリテ表ハレ、主トシテ末梢神經ヲ侵ス時ハ麻痺型トナリテ表ハレ、專ラ腦膜ヲ侵ス時ハ所謂人乳中毒症ノ型トナリテ表ハルルモノニアラザルカ、カカル關係ハカノ麻疹ノ例ニ於テ之ヲ見ル、即チ症状ノ劇烈ナルモノニ於テハ、多クハ肺炎ヲ合併シコレト同時ニ心臓衰弱ヲ招來スルモ、時トシテハ主トシテ中樞神經系統ニ障碍ヲ及ボシ、既ニ前驅期或ハ發疹期ノ初メニ於テ意識溷濁ヲ來シ遂ニ無慾状態ニ陷ルコトアリ、又恢復期ニ於テ稀ニ腦膜ヲ侵シ漿液性腦膜炎ヲ惹起スルモノアリ、是レ麻疹毒ハ時ニ主トシテ中樞神經系統ヲ侵スコトアルヲ意味スルモノニシテ、以上述ベタル余ノ乳兒脚氣ニ於ケル説明ト相符合スル點アルヲ以テ茲ニ之ヲ引用シタルニ過ギズ、カク觀察シ來ル時ハ精神症状ノ有無ハ敢テ問題トナスニ足ラザルナリ、余ハ所謂人乳中毒症ヲ乳兒脚氣腦型トナシ乳兒脚氣中ニ包括スルニ賛スル者ナリ。 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=池田嘉一郎 kn-aut-sei=池田 kn-aut-mei=嘉一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=大連醫院小兒科 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=365 article-no= start-page=317 end-page=321 dt-received= dt-revised= dt-accepted= dt-pub-year=1920 dt-pub=19200630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=間質性肺炎ニ因スル小兒氣胸ノ一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=本症例ハ瓣状ノ氣胸ニシテ、而モ兩側肋膜腔内ニハ些少ノ滲出液ヲモ容レザル眞ノ氣胸例ナリトス、而シテ本症例ニ於テ氣胸ヲ起シタル原因ヲ尋ヌルニ、本患者ハ臨牀上ビルケー氏反應陰性ニシテ、且病理解剖上何處ニモ結核性病竈ヲ證明セザリシヲ以テ見レバ、結核ニ原因シタルモノニアラザルヲ知ル、而シテ病理解剖上兩肺ニ於ケル肺氣腫、氣管枝擴張、慢性間質性肺炎等ノ存スル點ヨリ見レバ、患兒ハ發病一箇月前ニ毛細氣管枝炎ヲ患ヒ、其ノ際全治ニ至ラズシテ間質性肺炎ヲ續發シ、次デ代償性ニ肺氣腫乃至氣管枝擴張ヲ惹起シ、コレガアル機會ニ肋膜腔内ニ破壞シタルモノト想像スルヲ至當ナリト信ズ。 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=池田嘉一郎 kn-aut-sei=池田 kn-aut-mei=嘉一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=大連醫院小兒科 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=362 article-no= start-page=91 end-page=110 dt-received= dt-revised= dt-accepted= dt-pub-year=1920 dt-pub=19200331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ueber die eitrigen Blasenkatarrh im Kindesalter, hervorgerufen durch einen Kapselbacillus kn-title=「カプセルバチルス」ニ因スル小兒化膿性膀胱炎ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=池田嘉一郎 kn-aut-sei=池田 kn-aut-mei=嘉一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=大連醫院小兒科 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=375 article-no= start-page=287 end-page=342 dt-received= dt-revised= dt-accepted= dt-pub-year=1921 dt-pub=19210430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=膽汁酸鹽類ニ關スル研究竝ニ肝臟ノ生理ニ關スル知見補遺 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=池田嘉一郎 kn-aut-sei=池田 kn-aut-mei=嘉一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=大連醫院小兒科 END start-ver=1.4 cd-journal=joma no-vol=37 cd-vols= no-issue=428 article-no= start-page=900 end-page=928 dt-received= dt-revised= dt-accepted= dt-pub-year=1925 dt-pub=19250930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Zur pathologischen Histologie des Plexus chorioideus bei verschiedenen Erkrankungen kn-title=諸種疾患ニ於ケル脉絡叢ノ病理學的所見（承前） en-subtitle= kn-subtitle= en-abstract= kn-abstract=Die histopathologischen Veränderungen des Plexus chorioidei sind nur bei den Geisteskrankheiten einigermassen genauer studiert worden, während sie bei anderen Erkrankungen nur verhälthismässig wenig in der Literatur zu finden sind. Ich habe es deshalb unternommen, die feineren Veränderungen des Plexus chorioideus bei den verschiedensten Krankheiten eingehender zu untersuchen. Die Gesamtzahl der von mir untersuchten Fälle beträgt 188, die sich auf die folgenden 15 Krankheiten verteilen: Meningitiden 49 Fälle (d. h. tuberkulöse Meningitis 26, Encephalitis lethargica und sogenannte Meningitis 6, eitrige 10 und epidemische 7.), Spirochätosis ikterohämorrhagica (Morbus Weili) 18 Fälle, Hirntumor 5 Fälle, Dysenterie 9 Fälle, Typhus abdominalis 8 Fälle, Ekiri (eine der Kinderdysenterie verwandte Erkrankung) 4 Fälle, Lyssa 2 Fälle, Septicopyämie 3 Fälle, chronische myeloide Leukämie 2 Fälle, Pneumonie 7 Fälle, Lungentuberkulose 7 Fälle, Syphilis 5 Fälle und andere. Die Ergebnisse meiner Untersuchungen will ich im nachfolgenden kurz zusammenfassen. Leptomeningitis tuberculosa. Unter 26 Fällen desselben fand ich bei 23 Fällen tuberkulöse Herde in dem Flexus. Dabei spielten tuberkulöse Granulationsentzündungen die Hauptrolle, während die Bildung typischer Tuberkeln mehr in den Hintergrund trat. Typische Tuberkelbildung fand sich nur in 7 Fällen. Bei erstgenannten Fällen waren besonders zahlreiche Infiltrationszellen in den zottenfreien Teilen vorhanden, wenn sie auch in dem Zottenstroma nicht fehlten. Die Zottenstroma sind ödematös locker. Die Plexusepithelien waren meist gequollen und degeneritert, in manchen Fällen sogar desquamiert. In den zellig infiltrierten tuberkulösen Herden waren neben vereinzelten Plasmazellen und gewöhnlichen Lymphocyten auch gewisse Mengen der verschiedenartigen Makrophagen (im Sinne Metschnikoffs) vorhanden. Diese Makrophagen haben einen grossen Zelleib, dessen Gestalt rund, oval oder unregelmässig und dessen Protoplasma oft homogenisiert oder vacuolisiert ist. Die Zellen sind oft zwei- oder mehrkernig. Im Verhälthis zu dem grossen, blasigen Zelleibe ist der Kern retativ klein und häufig in der Peripherie gelegen. Die Form des Kernes ist verschieden, meist einfach rund oft oval. Diese Makrophagen enthalten oft rote Blutkörperchen, Reste von letzteren, ferner mehrere Leucocyten, Plasmazellen oder die in Zerfall begriffenen Zellen unbekannter Herkunft in ihrem Zelleibe. Manchmal enthalten mononukleäre Makrophagen keine körnigen bezw. zelligen Einschlüsse, sondern nur rundliche, etwas transparente Gebilden, die vielleicht durch Verflüssigung früher aufgenommener Zellen entstanden sind. Die Makrophagen finden sich nun nicht nur bei tuberkulöser Meningitis, sondern auch bei anderen Erkrankungen, so z. B. bei eitriger Meningitis, epidemischer Meningitis sowie bei Morbus Weili, Lyssa, Septicepyämie u. s. w. Aber sie zeigen verschiedene Beschaffenheiten je nach den Umständen. So Z. B. bei eiterigen Meningitiden sind ihre Kerne relativ gross und blass und findet sich im Zentrum des Zelleibs. Bei Morbus Welli erscheinen sie als grosse, den plasmazellen ähnliche Zellen, während sie bei Lyssa und Septicopyämie sich als grosse epitheloide Zellen präsentieren. Die Makrophagen zeigen bei tuberkulöser und eitriger Meningitis lebhafte phagozytöse Wirkung, während sie bei Lyssa und Septicopyämie dieselbe nur in geringem Masse ausführen. Bei Morbus Weili zeigten die Zottenstroma in vielen Fällen eine mehr oder weniger auffallende oedematöse Lockerung sowie zellige Infiltratinsherde von sehr verschiedener Stärke und Verteilung. Unter den Infiltrationszellen überwogen kleine und grosse Lymphozyten, denen auch zahlreiche Plasmazellen und Leukozyten beigemischt waren. Daneben waren grösere oder kleinere Blutungen fast stets zu konstatieren. Manchmal traten Blutungen und zellige Infiltration gleichzeitig auf. Soweit ich feststellen konnte, waren die entzündlichen Erscheinungen im Plexus chorioideus urn so hochgradiger, je früher der Tod eintrat, und zwar am hochgradigsten war die Entzüdung in den Fällen, die in 6-9 Tagen nach Krankheitsbeginn mit dem Tode ausgingen. Die Entzündungserscheinungen des Plexus Chorioideus steigern sich in der ersten Krankheitswoche allmählich in die Höhe und erreicht mit den erwähnten 6-9 Tagen in den höchsten Punkt, um dann allmählich wieder nachzulassen. So kann man bei denjenigen Fällen, welche um etwa 20 Krankheitstage gestorben sind, zellige Infiltration oder Blutungen nicht mehr im Plexus finden. In den 7 untersuchten Fallen von Meningitis cerebrospinalis epidemica war der Plexus chorioiclues ebenfalls von Entzündungen ergriffen. Das Zottenstroma ist mit zahlreiehen Eiterzellen, ausserdem aber auch mit mononucleaeren Zellen und Lymphocyten infiltriert. Haufen von abgestossenen Plexusepitbelien und Verkalkung sind häufig in dem Zottenstromi zu beobachten. In 10 Fällen von Meningitis purulenta war ebenfalls ausgedehnte, hochgradige eitrige Infiltration zu beobachten, zu der auch Lymphocyten und Plasmazellen sich mischten, also eine der epidemischen Meningitis ähnliche Veränderuog, jedoch hier in einen stärkerem Grade. Dementsprechend wurden die Blutungen hier in alien Fällen gefunden, während sie bei epidemischer Meningitis nur in 25% der Fälle. Abgestossene Epithelien und Makrophagen waren reichlich zu beobachten, ebenso Oedem des Zottenstromas und Verkalkung. Bei Encephalitis lethargica und sog. Meningitis fand ich stellenweise zellige Infiltrationsherde besonders im zottenfreien Teile. Auch grosse mononucleaere Zellen wurden zuweilen in solchen Herden beobachtet. Bei Lyssa zeigt der Plexus deutlich sichtbare entzündliche Erscheinuogen und Blutungen. Zu den Infiltrationszellen gesellen sich mässig zahlreich grosse, nur selten phagocytierende epitheloide Zellen. Das Oedem im Stroma ist sehr deutlich. Die Plexusepithelien sind aufgequollen, degeneriert und häufig abgestossen. Bei Septicopyämie finden sich ähnliche Veränderungen wie bei Lyssa, und zwar man trifft hier zuweilen auch eitrige Infiltrationen. Bei Typhus abdominalis, Dysenterie, Ekiri, Syphilis (angeborenen und erworbenen) und Pneumonie zeigte der Plexus chorioideus gewisse Veränderungen, die darin bestanden, dass das Bindegewebe sowohl des perivasculären Gewebes als auch des Zottenstromas zellreich wurde, was als das Zeichen von Entzündung anzufassen war. Die infiltrierten Zellen sind teils mononucleäre Zellen teils blasige Epitheloidzellen, teils Rundzellen, zu denen auch spärliche Leucozyten sich gesellten. Ausserdem waren abgestossene Plexusepithelien und wolkige Massen zwischen den Zotten in mässigem Grade vorbanden. Blutungen wurden beobachtet in 60% von Typhus abdominalis, 55% von Dysenterie, 57% von Pneumonia. Die Verkalkung war im Zottenstroma der Syphilisfälle am deutlichsten zu sehen. Bei Lungentuberculose zeigte der Plexus chorioideus keinerlei Veränderungen. In den Hirntumorfällen waren sehr deutliche Lockerung des Bindegewebes stärkere Blutfüllung der Gefasse, Quellung und spärliche Abstossung der Epithelien, sowie Auftreten von Riesenepithelien zu beobachten. Nur in 2 unter 5 Fällen waren ausserdem noch schwache Rundzelleninfiltration und geringe Blutungen zu finden. In den ehronisehen myeloiden Leucämiefällen konnte man ausser leucämischen Infiltrationen im Bindegewebe des Stromas deutliche Blutfullung in allen Gefässen der Zotten und bindegewebigen Grundplatten constatieren. Übrigens war das Stroma sehr locker gefügt und es gaben selten auch Abstossung der Plexusepithelien. en-copyright= kn-copyright= en-aut-name=IkedaMasao en-aut-sei=Ikeda en-aut-mei=Masao kn-aut-name=池田正夫 kn-aut-sei=池田 kn-aut-mei=正夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=九州帝國大學醫學部病理學教室 END start-ver=1.4 cd-journal=joma no-vol=37 cd-vols= no-issue=427 article-no= start-page=789 end-page=817 dt-received= dt-revised= dt-accepted= dt-pub-year=1925 dt-pub=19250831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=諸種疾患ニ於ケル脉絡叢ノ病理學的所見 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=池田正夫 kn-aut-sei=池田 kn-aut-mei=正夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=九州帝國大學醫學部病理學教室 END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue=447 article-no= start-page=446 end-page=454 dt-received= dt-revised= dt-accepted= dt-pub-year=1927 dt-pub=19270430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=神經系統ノ「インドフェニールオキシダーゼ」反應知見補遺 kn-title=Beiträge zur Kenntnis der Indophenoloxydasereaktion des Nervensystems en-subtitle= kn-subtitle= en-abstract= kn-abstract=動物體ノ「オキシダーゼ」反應ニ就イテハEhrlich氏以來多數ノ人々ニ依リ種々ノ方法ヲ以テ檢査セラレタリシガ神經系統ノ「オキシダーゼ」反應ニ關シテハEhrlich氏ハ腦ニ於テAbelous及ビBiarnès氏ハ腦ニ於テVernon氏ハ腦延髓及ビ小腦ニ於テIndopbenolblausyntheseヲ觀察シ只漠然ト其ノ陽性ナルカ陰性ナルカヲ述べ微細ナル點ニハ更ニ言及セズ. 又多クノ學者Slozon, Rosell, Kliopfer,藤原,池田其ノ他ハ神經系統ニハ「オキシダーゼ」ノ存在ヲ否定セリ. 然ルニGäff氏ハ神經組織ニ「オキシダーゼ」反應陽性ナル部分アルコトヲ主張シ殊ニ神經節細胞ニハ非常ニ多數ノ「オキシダーゼ」顆粒アルコトヲ證明セリ.然レドモ其ノ「オキシダーゼ」顆粒ノ微細ナル分布状態ニ關シテハ論及スルトコロナカリキ,勝沼博士ハ1915年v. Gierke氏法ヲ模倣シテ神經系統ノ「オキシダーゼ」反應ヲ精細ニ檢査シテ「オキシダーゼ」顆粒ノ分市状態ヲ詳細ニ記載セラレタリ. 1916年Düring氏ハ病理解屍體ノ新鮮ナル材料ヲ用ヒテ中樞神經節細胞ノ「オキシダーゼ」反應竝ニ其ノ意義ニ就イテ研究セリ. 1922年Kappers氏ハ魚類ノ腦ヲ用ヒテ其ノ神經節細胞ノ「オキシダーゼ」反應ヲ檢査セリ. 予モ亦本間題ニ就イテ上坂教授指導ノ下ニ詳細ナル檢査ヲ行ヘリ. 使用セル動物ハ家兎, 犬, 鼠ニシテv. Gierke氏法ヲ模倣シテ0.025%ノα-NaphtholトDimethylparaphenylendiaminトノ食鹽水溶液ヲ用ヒタリ. 檢査ノ結果次ノ如キ結論ヲ得タリ. 予ノ行ヘル檢査ノ成績ハ大體ニ於テ勝沼博士ノソレト大同小異ナリ. 中樞神經ノ灰白質ニ於テハ最初一般ニ瀰漫性ニ青染シヤガテ神經節細胞ニー致シテ著明ナル青色顆粒表ハル. 神經細胞核ハ本反應一般ニ陰性ニシテ微細ナル「インドフェノール」顆粒ヲ以テ充タサレタル細胞體ヨリ明カニ區別スル事ヲ得. 但シ小腦プルキンエ氏細胞,脊髓神經節細胞ハ例外ニシテ核小體ニ「オキシダーゼ」顆粒テ認メ得ルコトアリ. 尚ホ又脊髓前角ニ存スル運動神經細胞ハ其ノ核小體ハ多クノ場合極メテ微細ナル青色顆粒ヲ以テ充タサレタルヲ見タリ. 神經細胞ノ細胞體竝ニ其ノ樹枝状突起ハ微細ナル極メテ多數ノ「オキシグーゼ」顆粒ニテ充タサル之ニ反シ神經突起ニハ極メテ少數ノ青色顆粒存ス. 而モ一度青染セル切片ヲ室温中ニ放置スルニ神經突起ニ存スル青色顆粒ハ樹枝状突起ニ存スルモノヨリハ速ニ消失ス. 運動核ト知覺核トニヨリテハ「オキシグーゼ」反應ニハ差異ナキモノノ如シ, 然レドモ下橄欖ニ於テハ他ノ神經核ニ比シ其ノ「オキシダーゼ」顆粒ハ形稍大ニシテ其ノ數少キモノノ如シ. 中樞神經灰白質ハ全然「オキシダーゼ」反應陰性ナリ. 脊髓神經節ニ在リテハ同一種ノ細胞ト雖モ同樣ノ「オキシダーゼ」反應ヲ呈スルコトナク其ノ度極メテ種々ナリ. 強ク陽性ニ表ハルルモノハ多數ノ青色顆粒ヲ以テ其ノ細胞ヲ充タサルルニ反シ陽性ノ度弱キモノハ只核ノ周圍ニノミ極少數ノ「オキシグーゼ」顆粒存スルノミナリ. 斯ク種々ノ程度ニ染マリタル細胞ハ何等ノ配列ノ順序ナク不規則ニ混在ス. 中樞部ニ存在スル神經終末ハ三叉神經知覺繊維ニ就イテ檢スルニ「オキシダーゼ」反應陰性ナルモノノ如シ. 軸索ハ其ノ中樞神經細胞ヲ出テ極メテ僅カノ經過竝ニ末梢部終末ヲ除クノ外凡テ本反應陰性ナリ. Piamaterハ微ニ本反應陽性ナレドモ, 夫レガ神經繊維ト交叉シテ夫レヲ中樞部ト末梢部トニ區分スル部分ニアリテハ「オキシダーゼ」反應ハ全ク陰性ナルモノノ如シ. en-copyright= kn-copyright= en-aut-name=KumagaiKuranosuke en-aut-sei=Kumagai en-aut-mei=Kuranosuke kn-aut-name=熊谷藏之允 kn-aut-sei=熊谷 kn-aut-mei=藏之允 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=anatomischen Institut der Universität Okayama END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=3 article-no= start-page=187 end-page=192 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=原発性肺高血圧症の進行メカニズムの解明と治療薬の開発 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小川愛子 kn-aut-sei=小川 kn-aut-mei=愛子 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中村一文 kn-aut-sei=中村 kn-aut-mei=一文 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松原広己 kn-aut-sei=松原 kn-aut-mei=広己 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤尾栄起 kn-aut-sei=藤尾 kn-aut-mei=栄起 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=池田哲也 kn-aut-sei=池田 kn-aut-mei=哲也 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=宮地克維 kn-aut-sei=宮地 kn-aut-mei=克維 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三浦大志 kn-aut-sei=三浦 kn-aut-mei=大志 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三浦綾 kn-aut-sei=三浦 kn-aut-mei=綾 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=永瀬聡 kn-aut-sei=永瀬 kn-aut-mei=聡 aut-affil-num=9 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=草野研吾 kn-aut-sei=草野 kn-aut-mei=研吾 aut-affil-num=10 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=伊達洋至 kn-aut-sei=伊達 kn-aut-mei=洋至 aut-affil-num=11 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大江透 kn-aut-sei=大江 kn-aut-mei=透 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=University of California, San Diego, Division of Pulmonary and Critical Care Medicine affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科循環器内科 affil-num=3 en-affil= kn-affil=国立病院機構岡山医療センター循環器科 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科循環器内科 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科循環器内科 affil-num=6 en-affil= kn-affil=国立病院機構岡山医療センター循環器科 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科循環器内科 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科循環器内科 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科循環器内科 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科循環器内科 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科腫瘍・胸部外科 affil-num=12 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科循環器内科 en-keyword=原発性肺高血圧症 kn-keyword=原発性肺高血圧症 en-keyword=平滑筋細胞 kn-keyword=平滑筋細胞 en-keyword=prednisolone kn-keyword=prednisolone en-keyword=細胞周期 kn-keyword=細胞周期 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=3 article-no= start-page=227 end-page=230 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Treatment and care of intractable neurological diseases kn-title=神経内科領域の難治性疾患診療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaYoshio en-aut-sei=Ikeda en-aut-mei=Yoshio kn-aut-name=池田佳生 kn-aut-sei=池田 kn-aut-mei=佳生 aut-affil-num=1 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name=阿部康二 kn-aut-sei=阿部 kn-aut-mei=康二 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経内科学 en-keyword=神経難病 kn-keyword=神経難病 en-keyword=アルツハイマー病 kn-keyword=アルツハイマー病 en-keyword=パーキンソン病関連疾患 kn-keyword=パーキンソン病関連疾患 en-keyword=脊髄小脳変性症・多系統萎縮症 kn-keyword=脊髄小脳変性症・多系統萎縮症 en-keyword=筋萎縮性側索硬化症 kn-keyword=筋萎縮性側索硬化症 END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090319 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=津島岡大遺跡 19　―第30次調査―　（岡山大インキュベータ新営） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=池田晋 kn-aut-sei=池田 kn-aut-mei=晋 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=野崎貴博 kn-aut-sei=野崎 kn-aut-mei=貴博 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=宇田津徹朗 kn-aut-sei=宇田津 kn-aut-mei=徹朗 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=409 cd-vols= no-issue=4 article-no= start-page=663 end-page=668 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110617 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Plural assay systems derived from different cell lines and hepatitis C virus strains are required for the objective evaluation of anti-hepatitis C virus reagents en-subtitle= kn-subtitle= en-abstract= kn-abstract=Persistent hepatitis C virus (HCV) infection causes chronic liver diseases and is a global health problem. HuH-7 hepatoma-derived cells are widely used as the only cell-based HCV replication system for HCV research, including drug assays. Recently, using different hepatoma Li23-derived cells, we developed an HCV drug assay system (ORL8), in which the genome-length HCV RNA (O strain of genotype 1b) encoding renilla luciferase replicates efficiently. In this study, using the HuH-7-derived OR6 assay system that we developed previously and the ORL8 assay system, we evaluated 26 anti-HCV reagents, which other groups had reported as anti-HCV candidates using HuH-7-derived assay systems other than ORB. The results revealed that more than half of the reagents showed different anti-HCV activities from those in the previous studies, and that anti-HCV activities evaluated by the ORB and ORL8 assays were also frequently different. In further evaluation using the HuH-7-derived AH1R assay system, which was developed using the AH1 strain of genotype 1b, several reagents showed different anti-HCV activities in comparison with those evaluated by the OR6 and ORL8 assays. These results suggest that the different activities of anti-HCV reagents are caused by the differences in cell lines or HCV strains used for the development of assay systems. Therefore, we conclude that plural HCV assay systems developed using different cell lines or HCV strains are required for the objective evaluation of anti-HCV reagents. en-copyright= kn-copyright= en-aut-name=UedaYouki en-aut-sei=Ueda en-aut-mei=Youki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MoriKyoko en-aut-sei=Mori en-aut-mei=Kyoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AriumiYasuo en-aut-sei=Ariumi en-aut-mei=Yasuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IkedaMasanori en-aut-sei=Ikeda en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KatoNobuyuki en-aut-sei=Kato en-aut-mei=Nobuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences en-keyword=HCV kn-keyword=HCV en-keyword=HCV RNA replication system kn-keyword=HCV RNA replication system en-keyword=Li23 cells kn-keyword=Li23 cells en-keyword=Reporter assay for anti-HCV reagents kn-keyword=Reporter assay for anti-HCV reagents END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue=6 article-no= start-page=99 end-page=107 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Surface-Based Registrationを利用した 3次元CBCTimageの重ね合わせとその応用例(2) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=池田美和 kn-aut-sei=池田 kn-aut-mei=美和 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高木雅人 kn-aut-sei=高木 kn-aut-mei=雅人 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高山愛子 kn-aut-sei=高山 kn-aut-mei=愛子 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=佛坂斉祉 kn-aut-sei=佛坂 kn-aut-mei=斉祉 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三島克章 kn-aut-sei=三島 kn-aut-mei=克章 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田井規能 kn-aut-sei=田井 kn-aut-mei=規能 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=たい矯正歯科（岡山市） affil-num=2 en-affil= kn-affil=たい矯正歯科（岡山市） affil-num=3 en-affil= kn-affil=たい矯正歯科（岡山市） affil-num=4 en-affil= kn-affil=長崎大学大学院医菌薬稔合研究科歯科矯正学分野 affil-num=5 en-affil= kn-affil=山口大学大学院医学系研究科歯科口腔外科学分野 affil-num=6 en-affil= kn-affil=たい矯正歯科(岡山市) END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=2 article-no= start-page=129 end-page=132 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Laparoscopic surgery for mesenteric Castleman's disease kn-title=腹腔鏡下に摘出しえた上行結腸間膜発生のCastleman病の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report herein a case of mesenteric Castleman's disease which was confirmed on pathology. A 60-year-old man was admitted to our hospital complaining of abdominal pain. On the physical examination, there was no palpable mass. Computed tomography findings and magnetic resonance imaging revealed a well circumscribed, lobulated round mass on the right side of the superior mesenteric vein. Laparoscopic surgery for the mesenteric tumor was carried out to obtain a definite diagnosis and treatment. In the operative field, the mass was located on the ascending colic mesentery and measured about 3 cm in size. It was solid and surrounded by a thin fibrous capsule. The histological diagnosis of the mesenteric tumor was hyaline vascular type Castleman's disease. The postoperative course of the patient was uneventful, and he was discharged on the 10th postoperative day. en-copyright= kn-copyright= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=1 ORCID= en-aut-name=OtsukaShinya en-aut-sei=Otsuka en-aut-mei=Shinya kn-aut-name=大塚真哉 kn-aut-sei=大塚 kn-aut-mei=真哉 aut-affil-num=2 ORCID= en-aut-name=TomodaJun en-aut-sei=Tomoda en-aut-mei=Jun kn-aut-name=友田純 kn-aut-sei=友田 kn-aut-mei=純 aut-affil-num=3 ORCID= en-aut-name=FujiwaraKeishi en-aut-sei=Fujiwara en-aut-mei=Keishi kn-aut-name=藤原敬士 kn-aut-sei=藤原 kn-aut-mei=敬士 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　内科 affil-num=4 en-affil= kn-affil=光生病院　内科 en-keyword=結腸間膜 (mesocolon) kn-keyword=結腸間膜 (mesocolon) en-keyword=Castleman病 (Castleman's disease) kn-keyword=Castleman病 (Castleman's disease) en-keyword=腹腔鏡手術 (laparoscopic surgery) kn-keyword=腹腔鏡手術 (laparoscopic surgery) END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=2 article-no= start-page=119 end-page=127 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The study of "physicians' explanations" in medical malpractice lawsuits kn-title=医療訴訟における「医師の説明」に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this study, a subset of medical malpractice lawsuits that are preventable was evaluated using qualitative data. The objective of this study is to help reduce the number of avoidable medical malpractice lawsuits. This qualitative study could pave the way to future quantitative studies. The analysis of the qualitative data revealed that in the vast majority of medical malpractice lawsuits filed by patients and their families there were ① an occurrence of unexpected bad outcomes, ② inadequate explanation by the patient's physician, and ③ involvement of an instigator who encouraged the lawsuit. That is, the failure of a physician to provide an adequate explanation to a patient or the inappropriate conduct of a physician after unexpected bad results, with or without an instigator's involvement, is the main reason patients file medical malpractice lawsuits. The physician providing an adequate explanation to patients after unexpected bad results (adequate post-event explanation) is the pivotal determinative factor in preventing avoidable medical malpractice lawsuits. en-copyright= kn-copyright= en-aut-name=FukumotoYoshiyuki en-aut-sei=Fukumoto en-aut-mei=Yoshiyuki kn-aut-name=福本良之 kn-aut-sei=福本 kn-aut-mei=良之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 en-keyword=医療訴訟 (medical malpractice lawsuits) kn-keyword=医療訴訟 (medical malpractice lawsuits) en-keyword=医師の説明 (physicians' explanation) kn-keyword=医師の説明 (physicians' explanation) en-keyword=インフォームド・コンセント (informed consent) kn-keyword=インフォームド・コンセント (informed consent) en-keyword=説明義務 (accountability) kn-keyword=説明義務 (accountability) en-keyword=関与者 (instigator) kn-keyword=関与者 (instigator) END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=エストロゲンレセプターはmicrotubule-associated protein tau (MAPT)の発現に関与しており、選択的エストロゲンレセプター阻害剤であるフルベストラントは，MAPT発現を低下、乳癌細胞におけるタキサン系抗癌剤への感受性を増加させる kn-title=The estrogen receptor influences microtubule-associated protein tau (MAPT) expression and the selective estrogen receptor inhibitor fulvestrant downregulates MAPT and increases the sensitivity to taxane in breast cancer cells en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaHirokuni en-aut-sei=Ikeda en-aut-mei=Hirokuni kn-aut-name=池田宏国 kn-aut-sei=池田 kn-aut-mei=宏国 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=日本の家庭における乳児の寝具と寝床内気候 kn-title=Infant’s bed climate and bedding in the Japanese home setting en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaRie en-aut-sei=Ikeda en-aut-mei=Rie kn-aut-name=池田理恵 kn-aut-sei=池田 kn-aut-mei=理恵 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=1 article-no= start-page=33 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Investigation of laparoscopic therapy in 56 cases of duodenal ulcer perforation kn-title=十二指腸潰瘍穿孔に対する治療法の適応についての検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Although conservative therapy has been acceptable as the first-line therapy for duodenal ulcer (DU) perforations, surgical therapies are known to have certain advantages. We investigated the indications for laparoscopic (LS) or open surgery (OS) or conservative therapy (CoT) among 56 DU perforation cases over 5 years. Methods: 31 LSs, 22 OSs and 5 CoTs were analyzed for patient's physical and surgical factors and clinical course. Results: Mean age was 51.6. Male/female ratio was 49/9. Survival ratio was 98%. Although the hospital stay (10.9 vs 19.5 days) and analgesic administrations (1.9 vs 4.6 days) were significantly shorter in LS than OS, almost all OS patients were in serious condition as evidenced by longer waiting time before treatment, stronger pain, bigger hole of perforation, more ascites accumulation and higher morbidity of complications. Two cases of multisurgery were experienced in both LS and OS groups due to leakage of seam, abscess formation, relapsed ulcer or idiopathic intestinal perforation. LS is a therapy more widely usable and more beneficial than the other two. Conclusion: LS, a minimally invasive surgery for DU perforation, should be considered as a first-line standard therapy because of significant advantages such as shorter hospital stay. OS or CoT may be selected when appropriate. en-copyright= kn-copyright= en-aut-name=IshidoNobuhiro en-aut-sei=Ishido en-aut-mei=Nobuhiro kn-aut-name=石堂展宏 kn-aut-sei=石堂 kn-aut-mei=展宏 aut-affil-num=1 ORCID= en-aut-name=TamuraRyuji en-aut-sei=Tamura en-aut-mei=Ryuji kn-aut-name=田村竜二 kn-aut-sei=田村 kn-aut-mei=竜二 aut-affil-num=2 ORCID= en-aut-name=OkamotoTakahiro en-aut-sei=Okamoto en-aut-mei=Takahiro kn-aut-name=岡本貴大 kn-aut-sei=岡本 kn-aut-mei=貴大 aut-affil-num=3 ORCID= en-aut-name=KadowakiYoshihiko en-aut-sei=Kadowaki en-aut-mei=Yoshihiko kn-aut-name=門脇嘉彦 kn-aut-sei=門脇 kn-aut-mei=嘉彦 aut-affil-num=4 ORCID= en-aut-name=MoriTakashi en-aut-sei=Mori en-aut-mei=Takashi kn-aut-name=森隆 kn-aut-sei=森 kn-aut-mei=隆 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=神戸赤十字病院　外科 affil-num=2 en-affil= kn-affil=神戸赤十字病院　外科 affil-num=3 en-affil= kn-affil=神戸赤十字病院　外科 affil-num=4 en-affil= kn-affil=神戸赤十字病院　外科 affil-num=5 en-affil= kn-affil=神戸赤十字病院　外科 en-keyword=十二指腸潰瘍穿孔 (duodenal ulcer perforation) kn-keyword=十二指腸潰瘍穿孔 (duodenal ulcer perforation) en-keyword=腹腔鏡手術 (laparoscopic surgery) kn-keyword=腹腔鏡手術 (laparoscopic surgery) en-keyword=保存療法 (conservative therapy) kn-keyword=保存療法 (conservative therapy) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=85 end-page=105 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Pathogenesis of Hypoplastic Anemia (Panmyelopathia.) Part 3: Experimental studies of the developmental mechanism of anemia kn-title=再生不良性貧血（汎骨髓病症）の本態に関する研究 第三編 貧血の発生機転に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Having performed various experiments about rabbits of experimental anemia, in order to clarify causes of anemia, by injection of anemia-producing substance, obtained results as follows: 1) As to spleen-extirpated rabbit, it has incurred anemia by injection of serum. 2) The same would take place in case of liver-disturbed rabbit, due to serum injection. 3) No anemia was observed with the same injection, when the reticuloendothelial system was blocked with Indian ink. 4) Injecting the serum at a, nutricia femoris, and investigating the blood picture at v, nutricia femoris discovered a marked decrease both in the number of erythrocytes as well as leucocytes 2 hours later. 5) The serum iron value has proved a rise at the maximum anemic stage, in the successive injection. 6) The myelogram of the rabbit in case of successive injection, indicated a picture of maturation-arrest. 7) By all these facts stated above, it might be said, as for the factor to renderrabbit anemic, blood cell-arrest within bone marrow could be considered on one side, while the disturbance in the parenchym of the bone marrow might be imagined on the other. en-copyright= kn-copyright= en-aut-name=IkedaTakashi en-aut-sei=Ikeda en-aut-mei=Takashi kn-aut-name=池田隆 kn-aut-sei=池田 kn-aut-mei=隆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=65 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Pathogenesis of Hypoplastic Anemia (Panmyelopathia.) Part 2: The existence of anemia producing substances in urine, cerebrospinal fluid, and extracts of organs kn-title=再生不良性貧血（汎骨髓病症）の本態に関する研究 第二編 尿，髄液，諸臓器中の催貧血性物質 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author studied experimentally with the urine, cerebrospinal fluid, and extracts of bone marrow, spleen and the liver and obtained the results as follows;　1) In the urine, there is certain anemia-producing substance which is soluble in alcohol as well as ether, and exists in acid fraction.　2) In the cerebrospinal fluid, some anemia-producing substance could be discovered.　3) The bone marrow, the spleen and the liver have certain anemia-producing substance in their extracts. en-copyright= kn-copyright= en-aut-name=IkedaTakashi en-aut-sei=Ikeda en-aut-mei=Takashi kn-aut-name=池田隆 kn-aut-sei=池田 kn-aut-mei=隆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=43 end-page=63 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Pathogenesis of Hypoplastic Anemia (Panmyelopathia.) Part 1: Anemia-producing substance in the serum of patients kn-title=再生不良性貧血（汎骨髓病症）の本態に関する研究 第一編 血清中の催貧血性物質 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) If inject serum of this disease in rabbits, in every cases where injected once, as well as 7-times-continued case, haemoglobin, erylhrocytes, as well as platelet indicate a marked decrease. 2) No anemia-producing substance will be seen in serum either of healthy person or of posthemorrhagic anemic patient. 3) Those anemia producing substances found in the patient of this disease proved soluble both for alcohol as well as ether. 4) These substances exist in acid fraction. 5) These substances have the thermostable character for the 30 minutes heating of 100°C. en-copyright= kn-copyright= en-aut-name=IkedaTakashi en-aut-sei=Ikeda en-aut-mei=Takashi kn-aut-name=池田隆 kn-aut-sei=池田 kn-aut-mei=隆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=3 article-no= start-page=833 end-page=854 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Infectious Spectrum of Hepatitis Virus Isolated in Okayama Prefecture kn-title=岡山県下に発生した流行性肝炎特に病原体に関する研究 分離病毒の感染スペクトルに就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this report, the problem of infectious spectrum of hepatitis virus was studied by observing the establishment of infection and passage in various kinds of animals. The virus isolated from the hepatitis patients in Okayama Prefecture was used throughout this work, and the establishment of infection and passage was judged by the pathological appearances, of tissues. particularly of liver as the center, of inoculated animals. The results were as follows: 1) In mouse, embryonated egg and young hamster, the infection and passage of hepatitis virus were established. 2) In rat, guinea-pig, young dog and young cat, the establishment of infection could not be proved with certainty. 3) Among the used strains of virus, some difference was observed, which was probably originated from the difference of conditions at the isolation and passage of them. It was not conceivable, however, that remarkable difference of pathogenicity was present among them. 4) Putting together the aspects of infection, pathological figures and general natures of virus from the results of animal tests, the virus used in the present work is very simillar to the one reported by Havens, Maccallum and Wildführ. en-copyright= kn-copyright= en-aut-name=IkedaAkira en-aut-sei=Ikeda en-aut-mei=Akira kn-aut-name=池田明 kn-aut-sei=池田 kn-aut-mei=明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=12-1 article-no= start-page=7891 end-page=7895 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591120 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Electrocardiographic Study on Coronary Perfusion for Direct Vision Aortic Surgery Part II. Coronary Perfusion Combined with Extracorporeal Circulation kn-title=大動脈起始部直視下手術における冠灌流の心電図学的研究 第2編 体外循環使用下冠灌流における心電図学的考察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Both retrograde perfusion via the coronary sinus and direct perfusion of the coronary artery during extracorporeal circulation were studied. Following results were obtained. 1) Coronary perfusion associated with extracorporeal circulation under normothermic condition is far better than with hypothermia in maintainance of cardiac physiology. All the experiments are successfully performed in the case of direct perfusion in this series. 2) It is important to keep perfusion pressure at optimal level during perfusion, which is 35 mmHg. in retrograde and 120 mmHg. in direct perfusion, respectively. Perfusion rate should be controlled within these optimal pressure in each case. 3) Blood flow to mycardium is well maintained in direct perfusion than in retrograde perfusion. Maximum circulatory cessation over 50 minutes is secured in the former method compared to less than 20 minutes in the latter. However, direct perfusion is technically difficult in practice and some divice is needed to facilitate its clinical application. It is preferable to choose one of both methods after direct inspection of valvular lesions following preliminary retrograde perfusion. en-copyright= kn-copyright= en-aut-name=IkedaJushin en-aut-sei=Ikeda en-aut-mei=Jushin kn-aut-name=池田寿真 kn-aut-sei=池田 kn-aut-mei=寿真 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第2外科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=12-1 article-no= start-page=7879 end-page=7890 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591120 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Electrocardiographic Study on Coronary Perfusion for Direct Vision Aortic Surgery Part I. Coronary Perfusion Under Selective Brain Cooling kn-title=大動脈起始部直視下手術における冠灌流の心電図学的研究 第1編 選択的脳灌流冷却法下冠灌流における心電図学的考察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Both retrograde perfusion via the coronary sinus and direct perfusion of the coronary artery during circulatory occlusion under selective brain cooling were studied and evaluated from the electrocardiographic standpoint. The following results were obtained. 1) Hypothermia is not applicable for this type of experiment because irritability of myocardium is increased by hypothermia resulting ventricular fibrillation. 2) Direct perfusion is more physiologic than retrograde perfusion and circulatory cessation is maintained over 50 minutes without deleterious effect to myocardium compared to only 15 minutes available in the latter method. 3) Perfusion pressure not exceeding 35 mm Hg. in retrograde perfusion and below 120 mm Hg. in direct perfusion are optimal to obviate mycardial damage which is manifested as ST-T deviation in electrecardiogram. It is safe to keep temperature of perfusion blood between 36 and 37°C. Blood containing over 7.2 gl/dl Hb is applicable for perfusion if oxygenation is satisfactorily attained. en-copyright= kn-copyright= en-aut-name=IkedaJushin en-aut-sei=Ikeda en-aut-mei=Jushin kn-aut-name=池田寿真 kn-aut-sei=池田 kn-aut-mei=寿真 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第2外科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=11-1 article-no= start-page=7111 end-page=7125 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591020 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Histological Studies on Experimental Hepatitis with Ectromelia Virus Part 2 Studies on the Histological Chang of Various Organ Tissues by the Change of Inoculated Region kn-title=Ectromelia Virusに依る実験的肝炎の組織学的研究 第2篇 接種部位を変えた場合の体内諸種臓器組織の組織学的変化に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=The pathohistological changes of mice organ tissues were observed on the inoculation of ectromelia virus in the various changes of inoculated method and region. And the results were as follows. 1. The acute course was observed on the intraperitoneal inoculation, but it was subacute on the peroral and pernasal inoculation or the inoculation into the foot-sole. 2. The pathological changes of liver and spleen were diffuse on the intraperitoneal and peroral inoculation and it was local on the pernasal and subcutaneous inoculation or the in oculation into the foot-sole. 3. The change of intestine was the most remarkable on the peroral inoculation and the change of lung was the most remarkable on the pernasal inoculation. 4. The changes of organ tissues, other than those organs, were common to both of the occasions. 5. The presence of diffuse change in the organ was related to the density of invaded virus into organ and it was thought that the ectromelia virus was diluted by the systemic circulation. 6. The changes of liver and spleen were diffuse like epidemic hepatitis in human on the peroral administration and it was thought that bone of them showed a common infectious course. en-copyright= kn-copyright= en-aut-name=IkedaTamotsu en-aut-sei=Ikeda en-aut-mei=Tamotsu kn-aut-name=池田保 kn-aut-sei=池田 kn-aut-mei=保 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=11-1 article-no= start-page=7095 end-page=7109 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591020 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Histological Studies on Experimental Hepatitis with Ectromelia Virus Part 1 Studies on the Histological Changes of Various Organ Tissues by the Inoculation of Various Virus Dosis kn-title=Ectromelia Virusに依る実験的肝炎の組織学的研究 第1篇 接種Virus量を変えた場合の諸種臓器組織の組織学的変化に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=The changes of various organ tissues were hirtologically observed per day on the intraperitoneal inoculation of ectromelia virus to mouse. And the results were as follows. 1. The changes of various organ tissures found at first was the findings accompanied by the functional and organic changes of blood vessel, the changes of lymph vessel system, reticuloendothelial cell system and connective tissue system, and was the remarkable appearance of perilobular tissue reaction including the wandering cells, and then the change extended to the parenchymal tissue and the various organ tissues became showing the special pathologic picture respectively. 2. The living period of animal was contracted with the increase of inoculated virus dosis. And there was quantitative difference, but no qualitative difference on the histological change at that time, and the convalescent process was not found at all and the infiltration of round cell was also very few in the cases with the exceedingly short living period. 3. The histological change was especially remarkable in the liver, spleen and bone marrow, and it was hemorrhagic alveolitis in the lung and the pathologic picture of nephronephritis in the kiduey. 4. The changes at the maximum stadium of the cases inoculatied the extremely high dosis of ectromelia virus were similar to those of the histological pictures of various organs in fulminant hepatitis of human and the changes at the maximum stadium of the cases inoculated the relatively high dosis of ectromelia virus were similar to those of the histological pictures of various organs at the maximum stadium of acute hepatitis in human. And the histological pictures of liver at the period from the inoculation to the maximum stadium and those of the animals being relieved of death were also similar to those, examined by the liver biopsy, at the period from the beginning to the maximum stadium and at the convalescent stndium in human hepatitis. 5. The pathologic pictures of mice with the inoculation of ectromelia virus were very similar to those of epidemic hepatitis in human and it was thought that both of them were based on the interlobular reaction. en-copyright= kn-copyright= en-aut-name=IkedaTamotsu en-aut-sei=Ikeda en-aut-mei=Tamotsu kn-aut-name=池田保 kn-aut-sei=池田 kn-aut-mei=保 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=7-1 article-no= start-page=3783 end-page=3798 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Physiological and Bacteriological Traits of Tubercle Baccilli in the Excised Pulmonary Focus Part 2. The virulency of tubercel bacilli in the excised pulmonary focus kn-title=切除肺病巣内結核菌の生物学的，細菌学的性状に関する研究 第2編 切除肺病巣内結核菌と毒力について en-subtitle= kn-subtitle= en-abstract= kn-abstract=By inoculating into the tail vein of mice 40 samples of culture positive bacilli obtained from different kinds of the excised pulmonary foci and by the estimation culture of the viscera of these test animals, the author studied the virulency of the tubercle bacilli, and also carried out observations on the relationship between the color reaction and the ability of cord formation. 1. Tubercle bacilli in the excised pulmonary focus generally tend to show a less potent virulency that that of H(37)Rv, human F strain, and ones isolated from human sputum. 2. However, the tubercle bacilli from the cavity expelling becilli up to the time of operation show the virulency almost as potent as the tubercle bacilli isolated from sputum. The longer the time after the cessation of bacillus expulsion the weakeer the virulency tends to be. In the caseous focus the virulency of bacilli tends to be less potent than in the case of the cavity. In addition, the softer the contents of the focus the weaker is the bacilli. 3. Tubercle bacilli in sll kinds of foci show no fixed relationship between the virulency on one hand and the size of focus, the kind and amount of drug administered befoer operation, and collapse therapy or no collapse theapy on the other hand. 4. Of various stainings, neutral red reaction in the case of extremely strong or extremely weak stain coincides well with the degree of virulency in the animal experiment, but in the case staining in an intermediate degree, although coinciding well with the potency of virulency, it does not necessarily agree with the results of animal experiment. It seems that this method is fairly useful for a rough estimatiou of the virulency of tubercle bacilli but it is not adequate enough for a precise analysis. Furthemore, P-K reduction test will yield the degree of virulency to a certain extent for the virulent strain, but for the determination of the degree of virulency in human infected bacilli, irrespective of the potency observed in animal experiment, no maked discoloration can be observed by this thst and it seems to possess no great significance. 5. No fixed relationship between the resistance against SM and PAS and the virulency toward mice, but in the case of INAH-resistant strain that acquired the resistance of over 10 γ, a weakening tendency can be recognized in their virulency. Such a tendancy has also been observed in the N-R reduction test. In addition, no decrease in the coloration can be recongized by the N-R reaction in SM-highly-resistant strain. 6. The cases showing the colony formation even after a long period of culture carried over 8 weeks amount to 12.7 per cent, but the number of colonies is small in all cases, snggesting a fall in the power of subsistence. However, the virulency is not necessarily diminished. Judging from the fact that with an exeption of the bacilli in the cavity expelling bacilli np to the operation, the potencyof the virulency and the power of subsistence in the majority of badillido not coincide with one another and that the virulency grows less potent along with the encapsulation and hardeniog of the foci, it is not difficult to understand that most of tubercle bacilli found in foci undergo physiological and bacteriological changes to a greaert extent than those tubercle bacilli usually found in the sputum of patient. Furthermore, in two caseous foci whose diamater is under 0.5 cm and whose contents are caseously hardened, the bacilli, though weak in viruleucy, have beeu found to be positive to the estimation culture. It is not reasonably impossible to say that such characteristic trait of tubercle bacilli may recover the virulency, and from such a reasoning there remains a problem to be solved before deciding definitively that the bacilli proving to be smear-positive and culture-negative are all dead. en-copyright= kn-copyright= en-aut-name=IkedaHiroshi en-aut-sei=Ikeda en-aut-mei=Hiroshi kn-aut-name=池田宏 kn-aut-sei=池田 kn-aut-mei=宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部内科学教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=7-1 article-no= start-page=3765 end-page=3781 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Physiological and Bacteriological Traits of Tubercle Baccilli in the Excised Pulmonary Focus Part 1. Various traits and resistance of tubercle bacilli in the excised pulmonary focus kn-title=切除肺病巣内結核菌の生物学的，細菌学的性状に関する研究 第1編 切除肺病巣内結核菌の諸性状と耐性について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Out of 207 cases of pulmonary resection, the author studied tubercle bacilli in 314 foci by smear, culture and estimation of resistance with the purpose to find out the characteristic traits of these bacilli, and obtained the following results. Smear positive ones occupy 94.2 per cent while culture positive only 45.2 per cent, and smear positive, culture negative ones occupy 49.7 per cent. The smear positive rate by various methods of staining is poorest in the case of Ziehl-Neelsen method and highest in the fluorescent method. There can be found no difference in the culture result whether cultured in an untreated 1% ogawa medim, 4% sodinm hydrocide-treated medium or untreated-3% ogawa medium. It seems that the question whether or not the tubercle bacilli in the focus are culture positive does not depend so much on the kind of chemotherapy, the dose of drug administered or duration of the treatment, but it rather depends on the character of the focus, and the effect of the chemotherapy affects indirectly ans secondarily, and that after the closing of focus and the hardening of contents with lapse of time smear positive-culture negative cases will increase in number. In the case given chemotherapy and collapse treatment prior to the resection, no fixed relationship can be observed in the cavity but in the case of the caseous cavity accompanied by penumothorax many culture positive ones can be recognized. In the case whose bacillib in the focus proved to be culture negative the majority of them show the normal value of the blood sedimentation before operation, and in these showing the value over 21 mm most of the bacilli in the cavity prove to be culture positive. The acquiring of resistance by the bacilli in the focus is dependent on the character of the focus rather than the dose of drugs or the duration of the treatment. In the open focus treated with a large dose of drug for a long period of time the resistance of bacilli in the focus is high, while the resistance of the bacilli in the encapsulated focus is generally low. However, even in the same kind of foci the resistance of bacilli tends to be higher in the foci whose contents are softer, and the same thing can be said of bacilli in different kinds of foci. Even in the cavity which stopped expelling bacilli soon after the start of chemotherapy, when the chmotherapy is continued for a long time afterward, generally there is no rising tendency in the resistance of bacilli in the focus. As for the degree of resistance acquired by bacilli against various drugs, the majority acquire a higher resistance against SM, and the resistance against PAS is on the whole low, while that ahainst INAH is approxiamtely similar to that against SM. en-copyright= kn-copyright= en-aut-name=IkedaHiroshi en-aut-sei=Ikeda en-aut-mei=Hiroshi kn-aut-name=池田宏 kn-aut-sei=池田 kn-aut-mei=宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部内科学教室 END start-ver=1.4 cd-journal=joma no-vol=101 cd-vols= no-issue=3-4 article-no= start-page=285 end-page=293 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198904 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of cellular oncogenes in human bone and soft tissue tumors kn-title=ヒト骨・軟部腫瘍組織における癌遺伝子の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The amplification and rearrangement of five cellular oncogenes (c-myc, c-K-ras, c-fos, c-raf-1, and N-myc) were studied by Southern hybridization in fourteen human bone and soft tissue tumors obtained at surgery. Amplification of c-myc was detected in the two of four osteosarcomas and one of two malignant fibrous histiocytomas. The c-myc genes in these tissues were amplified 4- to 8-fold in comparision with the placenta DNA. One of these osteosarcomas had 16- to 32-fold amplification of c-raf-1 gene without rearrangement. The clinical course of osteosarcoma and malignant fibrous histiocytoma with the amplified c-myc or c-raf-1 gene showed a rapid malignant progress with lung or bone metastasis. There appears to be a correlation between clinical prognosis and oncogene amplification. en-copyright= kn-copyright= en-aut-name=SumiiHiroshi en-aut-sei=Sumii en-aut-mei=Hiroshi kn-aut-name=住居広士 kn-aut-sei=住居 kn-aut-mei=広士 aut-affil-num=1 ORCID= en-aut-name=InoueHajime en-aut-sei=Inoue en-aut-mei=Hajime kn-aut-name=井上一 kn-aut-sei=井上 kn-aut-mei=一 aut-affil-num=2 ORCID= en-aut-name=ItoShiro en-aut-sei=Ito en-aut-mei=Shiro kn-aut-name=伊藤士郎 kn-aut-sei=伊藤 kn-aut-mei=士郎 aut-affil-num=3 ORCID= en-aut-name=TanabeGozo en-aut-sei=Tanabe en-aut-mei=Gozo kn-aut-name=田辺剛造 kn-aut-sei=田辺 kn-aut-mei=剛造 aut-affil-num=4 ORCID= en-aut-name=TakechiHideo en-aut-sei=Takechi en-aut-mei=Hideo kn-aut-name=武智秀夫 kn-aut-sei=武智 kn-aut-mei=秀夫 aut-affil-num=5 ORCID= en-aut-name=IkedaShogo en-aut-sei=Ikeda en-aut-mei=Shogo kn-aut-name=池田正五 kn-aut-sei=池田 kn-aut-mei=正五 aut-affil-num=6 ORCID= en-aut-name=OdaTakuzo en-aut-sei=Oda en-aut-mei=Takuzo kn-aut-name=小田琢三 kn-aut-sei=小田 kn-aut-mei=琢三 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部整形外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部整形外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部整形外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部整形外科学教室 affil-num=5 en-affil= kn-affil=吉備高原医療リハビリテーションセンター affil-num=6 en-affil= kn-affil=岡山大学医学部癌源研究施設生化学部門 affil-num=7 en-affil= kn-affil=岡山大学医学部癌源研究施設生化学部門 en-keyword=Oncogene kn-keyword=Oncogene en-keyword=Gene amplification kn-keyword=Gene amplification en-keyword=c-myc kn-keyword=c-myc en-keyword=c-raf-1 kn-keyword=c-raf-1 en-keyword=Osteosarcoma kn-keyword=Osteosarcoma en-keyword=MFH kn-keyword=MFH END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=9-10 article-no= start-page=1175 end-page=1185 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199010 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An experimental study of hepatic blood flow and oxygen metabolism with the portal vein transiently blocked kn-title=一時的門脈遮断時における肝血流と酸素代謝に関する実験的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Though numerous studies of systemic hemodynamics concerned with transient blockade of the portal vein exist, few studies have been performed specifically to assess blood flow and oxygen metabolism in the liver under such conditions. We blocked the portal vein in adult mongrel dogs and measured systemic hemodynamics, hepatic blood flow, total oxygen delivery to the liver, and the oxygen consumption and extraction ratio in order to evaluate the effect of a blockade of the portal vein on hepatic oxygen metabolism. In addition, a portal vein bypass was established and its effect on the liver was evaluated in comparison to a simple blockade of the portal vein. The results suggested that arterial blood pressure and cardiac output declined severely upon simple blockade of the portal vein, and a decrease in total hepatic blood flow which could be avoided by establishing a portal vein bypass was also observed. Simple blockade of the portal vein maximally accelerated the oxygen extraction ratio, though oxygen consumption by the liver significantly decreased due to insufficient oxygen supply caused by the decrease in blood flow in the hepatic artery. With a portal vein bypass, however, blood flow in the hepatic artery did not fall, oxygen consumption was maintained at a constant level, and a moderate rise in the oxygen extraction ratio was observed. These results indicate that establishing a portal vein bypass may be useful to protect the liver. en-copyright= kn-copyright= en-aut-name=IkedaToshio en-aut-sei=Ikeda en-aut-mei=Toshio kn-aut-name=池田敏夫 kn-aut-sei=池田 kn-aut-mei=敏夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=門脈遮断 kn-keyword=門脈遮断 en-keyword=肝血流 kn-keyword=肝血流 en-keyword=酸素代謝 kn-keyword=酸素代謝 en-keyword=バイパス kn-keyword=バイパス END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=5-6 article-no= start-page=663 end-page=678 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199006 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental study of optimal fat/glucose ratio for total parenteral nutrition in rats kn-title=TPN下における糖,脂肪乳剤の至適配合比の検討 ―RI燃焼率，臓器内分布，生化学的検査,窒素出納よりの検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=The optimal fat/glucose ratio for TPN was determined, using oxidation and distribution of (14)C labeled fat emulsion and glucose. Animals were divided into five groups according to percentage of energy supplied as fat i·e. 0%, 20%, 40%, 60% and 80%, respectively. (14)C-labeled fat emulsion and glucose were injected during TPN and the rate of oxidation to (14)CO(2) as well as (14)C distribution in various organs were measured. Oxidation of (14)C-glucose was constant in all groups and that of (14)C-labeled fat emulsion was inversely related to the amount of glucose administered simultaneously. (14)C-distribution in adipose tissue was correlated to the amount of glucose infused. As oxidation of glucose was significantly higher than that of fat, the higher the fat content of non-protein calorie, the less oxidation was observed. The groups given 60% and 80% energy composed of fat, showed less nitrogen retention and glycogen content in liver and muscle. These two groups exhibited high blood levels of free fatty acid, cholesterol and phospholipids. These findings suggest that the optimal blending ratio of fat would be around 20-40% of the non-protein calories. en-copyright= kn-copyright= en-aut-name=IkedaAkihiko en-aut-sei=Ikeda en-aut-mei=Akihiko kn-aut-name=池田昭彦 kn-aut-sei=池田 kn-aut-mei=昭彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=(14)C標識化ブドウ糖 kn-keyword=(14)C標識化ブドウ糖 en-keyword=(14)C標識化脂肪乳剤 kn-keyword=(14)C標識化脂肪乳剤 en-keyword=脂肪代謝 kn-keyword=脂肪代謝 END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=3 article-no= start-page=219 end-page=223 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20101201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Radiotherapy for choroidal hemangioma kn-title=脈絡膜血管腫に対する放射線治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract=PURPOSE: Circumscribed choroidal hemangioma is an uncommon, benign vascular tumor that typically appears in the posterior pole of the eye. Visual acuity loss typically results from its exudation, followed by serous retinal detachment. The purpose of the study was to evaluate the efficacy and the safety of external beam irradiation in treating circumscribed choroidal hemangioma. METHODS: We treated 4 eyes of 4 patients with circumscribed choroidal hemangioma with external beam irradiation at Okayama University Hospital from 2002 to 2009. A total absorbed dose of 20 Gy (beam energy, 4, 10 MV) was applied to each of the 4 patients. Each patient received a single 2-Gy daily fraction for five consecutive days in a week, for two consecutive weeks. RESULTS: In all cases, the retinal detachment showed complete resolution within 8 to 48 days after treatment. A decrease in tumor thickness was observed in all cases except one in which the follow-up period was rather short (3.7 months). The visual acuity improved in all 4 eyes. No eyes showed deterioration of visual acuity. During follow-up periods of 3.7 months to 58.5 months, there were no signs of radiation-induced cataract, retinopathy or optic neuropathy. en-copyright= kn-copyright= en-aut-name=HaradaSosuke en-aut-sei=Harada en-aut-mei=Sosuke kn-aut-name=原田聡介 kn-aut-sei=原田 kn-aut-mei=聡介 aut-affil-num=1 ORCID= en-aut-name=TakemotoMitsuhiro en-aut-sei=Takemoto en-aut-mei=Mitsuhiro kn-aut-name=武本充広 kn-aut-sei=武本 kn-aut-mei=充広 aut-affil-num=2 ORCID= en-aut-name=YoshioKoutarou en-aut-sei=Yoshio en-aut-mei=Koutarou kn-aut-name=吉尾浩太郎 kn-aut-sei=吉尾 kn-aut-mei=浩太郎 aut-affil-num=3 ORCID= en-aut-name=KojimaKatsuhide en-aut-sei=Kojima en-aut-mei=Katsuhide kn-aut-name=児島克英 kn-aut-sei=児島 kn-aut-mei=克英 aut-affil-num=4 ORCID= en-aut-name=KatayamaNorihisa en-aut-sei=Katayama en-aut-mei=Norihisa kn-aut-name=片山敬久 kn-aut-sei=片山 kn-aut-mei=敬久 aut-affil-num=5 ORCID= en-aut-name=KatsuiKuniaki en-aut-sei=Katsui en-aut-mei=Kuniaki kn-aut-name=勝井邦彰 kn-aut-sei=勝井 kn-aut-mei=邦彰 aut-affil-num=6 ORCID= en-aut-name=KurodaMasahiro en-aut-sei=Kuroda en-aut-mei=Masahiro kn-aut-name=黒田昌宏 kn-aut-sei=黒田 kn-aut-mei=昌宏 aut-affil-num=7 ORCID= en-aut-name=MatsuoToshihiko en-aut-sei=Matsuo en-aut-mei=Toshihiko kn-aut-name=松尾俊彦 kn-aut-sei=松尾 kn-aut-mei=俊彦 aut-affil-num=8 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name=金澤右 kn-aut-sei=金澤 kn-aut-mei=右 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　放射線科 affil-num=2 en-affil= kn-affil=岡山大学病院　放射線科 affil-num=3 en-affil= kn-affil=岡山大学病院　放射線科 affil-num=4 en-affil= kn-affil=岡山大学病院　放射線科 affil-num=5 en-affil= kn-affil=岡山大学病院　放射線科 affil-num=6 en-affil= kn-affil=岡山大学病院　放射線科 affil-num=7 en-affil= kn-affil=岡山大学大学院保健学研究科　放射線技術科学分野 affil-num=8 en-affil= kn-affil=岡山大学病院　眼科 affil-num=9 en-affil= kn-affil=岡山大学病院　放射線科 en-keyword=放射線治療 (radiation therapy) kn-keyword=放射線治療 (radiation therapy) en-keyword=照射 (irradiation) kn-keyword=照射 (irradiation) en-keyword=脈絡膜 (choroid) kn-keyword=脈絡膜 (choroid) en-keyword=眼腫瘍 (ocular tumor) kn-keyword=眼腫瘍 (ocular tumor) en-keyword=血管腫 (hemangioma) kn-keyword=血管腫 (hemangioma) END start-ver=1.4 cd-journal=joma no-vol=2008 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100226 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Bulletin of Archaelogical Research Center Okayama University 2008 kn-title=岡山大学埋蔵文化財調査研究センター紀要2008 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岩﨑志保 kn-aut-sei=岩﨑 kn-aut-mei=志保 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=池田晋 kn-aut-sei=池田 kn-aut-mei=晋 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=野崎貴博 kn-aut-sei=野崎 kn-aut-mei=貴博 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山本悦世 kn-aut-sei=山本 kn-aut-mei=悦世 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=4 article-no= start-page=171 end-page=178 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=200308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Differential responses of serum gamma-glutamyltransferase to alcohol intake in Japanese males. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We studied the association of gamma-glutamyltransferase (GGT) and other serum markers of liver injury with daily alcohol consumption in a healthy population of 1,043 Japanese males. A positive correlation between daily alcohol consumption and biochemical markers, such as log GGT (r = 0.432), log AST (r = 0.244) or log LAP (r = 0.246), was seen in all drinkers. However, there was a negative correlation, such as log GGT (r = -0.434), log AST (r = -0.424) or log LAP (r = -0.430), in heavy drinkers who consumed more than 70 g ethanol a day. On the other hand, a positive correlation, such as log GGT (r = 0.426), log AST (r = 0.247) or log LAP (r = 0.216) was found in moderate drinkers who consumed less than 70 g ethanol a day. Interestingly, there was a tendency toward negative association between alcohol consumption and the Tokyo University ALDH2 Phenotype Screening Test (TAST) score in the heavy drinkers, and there was a tendency toward positive association between GGT and TAST score in this group. Our results suggest that there are 2 groups of drinkers, those with elevated GGT (good responders) and those with normal GGT (poor responders) despite heavy drinking.

en-copyright= kn-copyright= en-aut-name=MatsukaYoko en-aut-sei=Matsuka en-aut-mei=Yoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WangDa-Hong en-aut-sei=Wang en-aut-mei=Da-Hong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuganumaNarufumi en-aut-sei=Suganuma en-aut-mei=Narufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ImaiKaori en-aut-sei=Imai en-aut-mei=Kaori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KiraShohei en-aut-sei=Kira en-aut-mei=Shohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama Univresity affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University en-keyword=gamma-glutamyltransferase(GGT) kn-keyword=gamma-glutamyltransferase(GGT) en-keyword=daily alcohol consumption kn-keyword=daily alcohol consumption en-keyword=good responder and poor responder kn-keyword=good responder and poor responder END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue=6 article-no= start-page=265 end-page=273 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=200012 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Epidemiological studies of coincidental outbreaks of enterohemorrhagic Escherichia coli O157:H7 infection and infectious gastroenteritis in Niimi City. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A sharp rise in the number of patients with infectious gastroenteritis was observed in the 25th week of year 1996 in the Takahashi-Ashin district by researchers with the Infectious Disease Surveillance Program for tuberculosis and other infectious diseases in the Okayama Prefecture. This sharp rise occurred coincidentally with an outbreak of enterohemorrhagic Escherichia coli O157:H7 (EHEC O157) infection in Niimi City of the Takahashi-Ashin district. However, this phenomenon of coincidental outbreaks was not observed during the outbreak of EHEC O157 infection in Oku Cho. By reviewing outpatients' charts in a sentinel hospital in Niimi City for the Infectious Disease Surveillance Program, it was noted that patients with acute gastrointestinal infection visiting the hospital during the increased incidence of infectious gastroenteritis may have been included as misclassified cases of EHEC O157 infection. On the other hand, the exponential probability plotting of symptomatic patients with EHEC O157 infection in Niimi City revealed a breaking point which suggested a dual exposure to contaminated food or an overlap with other acute gastrointestinal infections. The latter possibility was discounted, because stool culture-positive patients with EHEC O157 infection also exhibited a similar breaking point, and furthermore, the coincidental increase in infectious gastroenteritis in the same area was attributable to the EHEC O157 infection. The present study demonstrates the association between the sharp rise in gastroenteritis and the outbreak of EHEC O157 in the Takahashi-Ashin district. A careful analysis of the cases of infectious gastroenteritis by the Infectious Disease Surveillance Program would have predicted the outbreak of EHEC O157.

en-copyright= kn-copyright= en-aut-name=TsumagariKenji en-aut-sei=Tsumagari en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamamotoHideki en-aut-sei=Yamamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuganumaNarufumi en-aut-sei=Suganuma en-aut-mei=Narufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KatoMasahiko en-aut-sei=Kato en-aut-mei=Masahiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ImaiKaori en-aut-sei=Imai en-aut-mei=Kaori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KiraShohei en-aut-sei=Kira en-aut-mei=Shohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Fukui Medical School affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=University of Occupational and Environmental Health affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University en-keyword=enterohemorrhangic Escherichia coli O157 infection kn-keyword=enterohemorrhangic Escherichia coli O157 infection en-keyword=infectious gastroenteritis kn-keyword=infectious gastroenteritis en-keyword=Niimi City kn-keyword=Niimi City en-keyword=epidemiological studies kn-keyword=epidemiological studies en-keyword=surveillance kn-keyword=surveillance END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=5 article-no= start-page=269 end-page=276 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=200111 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Serum total cholesterol of new students enrolled at Okayama University: trend during 1989-1998. en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OguraToshio en-aut-sei=Ogura en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsuuraKazuharu en-aut-sei=Matsuura en-aut-mei=Kazuharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuzukiHisao en-aut-sei=Suzuki en-aut-mei=Hisao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KishidaMasayuki en-aut-sei=Kishida en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TsukamotoChiaki en-aut-sei=Tsukamoto en-aut-mei=Chiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ImaiAyumi en-aut-sei=Imai en-aut-mei=Ayumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TobeKazuo en-aut-sei=Tobe en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Health and Medical Center affil-num=2 en-affil= kn-affil=Health and Medical Center affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Health and Medical Center affil-num=5 en-affil= kn-affil=Health and Medical Center affil-num=6 en-affil= kn-affil=Health and Medical Center affil-num=7 en-affil= kn-affil=Health and Medical Center affil-num=8 en-affil= kn-affil=Health and Medical Center END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue=3 article-no= start-page=127 end-page=138 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198606 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Distribution of electrophoretically separated serum high density lipoprotein subfraction levels among healthy students and its alteration in patients with liver diseases. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

In an attempt to evaluate high density lipoprotein (HDL) subfraction levels in liver diseases, HDL was separated by a precipitation method with dextran sulfate-Mg2+ from sera of 289 healthy adults and 50 patients with liver diseases. The HDL was subdivided into HDL2e and HDL3e by Utermann's polyacrylamide gel electrophoresis with lauric acid. Ultracentrifugally separated HDL2 and HDL3 roughly corresponded to HDL2e and HDL3e, respectively. Male and female groups had different distributions of HDL2e/HDL3e ratios. Among healthy males, 121 cases had ratios less than 1.0 (mean +/- SD = 0.72 +/- 0.39, n = 150), while among healthy females, the ratios were generally larger than those of males and varied widely from 0.2 to 6.6 (mean +/- SD = 1.77 +/- 1.05, n = 139). Low levels of HDL-cholesterol were found in patients with liver diseases, except those with mild alcoholic liver injury and intrahepatic cholestasis. Apparent decreases in HDL3e, but not in HDL2e, were found in all cases with liver diseases investigated, even in those who did not show decreases in the total HDL level, when male and female patients were analyzed separately. The analysis of HDL subfractions by the present method is simple and useful for the study on altered lipid metabolism in liver diseases.

en-copyright= kn-copyright= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University en-keyword=HDL2 kn-keyword=HDL2 en-keyword= HDL3 kn-keyword= HDL3 en-keyword=HDL-cholesterol kn-keyword=HDL-cholesterol en-keyword=electrophoresis kn-keyword=electrophoresis en-keyword=liver disease kn-keyword=liver disease END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=1 article-no= start-page=31 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Seroepidemiologic Studies of Hepatitis C Virus Infection in a Population of Okayama Prefecture Screened for Liver Disease en-subtitle= kn-subtitle= en-abstract= kn-abstract=

To better understand the spread of hepatitis C virus (HCV) infection, we studied the association of HCV infection with similarly transmissible hepatitis B virus (HBV) infection and with hepatitis A virus (HAV) infection, which is supposed to be related to a nosocomial transmission of HCV. This was done by studying the presence or absence of antibodies to these viruses, as well as hepatitis B surface antigen, in a population of 1,398 inhabitants with abnormal liver function tests or history of liver disease and/or blood transfusion. This group was drawn from a group of 7,905 examinees screened for liver disease in 26 districts of Okayama prefecture, Japan. The prevalence of antibody-positive cases increased with age for those viruses. Small but significantly increased odds ratios were obtained among anti-HCV antibodies (HCVAb), anti-hepatitis B core antibodies (HBcAb) and anti-hepatitis A antibodies (HAVAb). After adjusting odds ratios by logistic regression analysis, a significant association was present only between HCVAb and HBcAb. The distribution of age-adjusted prevalences (AAP) of HCVAb in 26 districts was significantly wider than those of HBcAb or HAVAb. The district-based AAP of HCVAb, but not of HBcAb and HAVAb, correlated significantly with the district-based prevalence of infectious hepatitis having a tendency of chronicity reported in 1953-1955. Adjusted odds ratios calculated by logistic regression analysis of the virus markers showed that HCVAb was significantly associated with a past history of blood transfusion. Thus, the spread of HCV infection is speculated to have been triggered by blood transfusion, particularly from paid donors initially, followed by transmission by nosocomial or close person-to-person contact.

en-copyright= kn-copyright= en-aut-name=UesugiSeiichiro en-aut-sei=Uesugi en-aut-mei=Seiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=RimalNirmal en-aut-sei=Rimal en-aut-mei=Nirmal kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KariyaTetsu en-aut-sei=Kariya en-aut-mei=Tetsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SuganumaNarufumi en-aut-sei=Suganuma en-aut-mei=Narufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamamotoHideki en-aut-sei=Yamamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KiraShohei en-aut-sei=Kira en-aut-mei=Shohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama Health Foundation affil-num=6 en-affil= kn-affil=Okayama Health Foundation affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University en-keyword=hepatitis A kn-keyword=hepatitis A en-keyword=hepatitis B kn-keyword=hepatitis B en-keyword=hepatitis C kn-keyword=hepatitis C en-keyword=seroepidemiology kn-keyword=seroepidemiology en-keyword=route of infection kn-keyword=route of infection en-keyword=blood exposure kn-keyword=blood exposure END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=3 article-no= start-page=133 end-page=140 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Urinary excretion of type I collagen cross-linked N-telopeptides, bone mass and related lifestyle in middle-aged women. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The relationship between past and present lifestyle and urinary excretion of type I collagen cross-linked N-telopeptides (NTx) was studied in 61 Japanese females aged 34-59, with a view toward using NTx excretion rates as a predictor of future osteoporosis. Bone mineral density (BMD) of the lumbar spine, the speed of sound (SOS) and broadband ultrasound attenuation (BUA) of the os calcis, urinary NTx, serum osteocalcin (BGP) and bone-specific alkaline phosphatase (BAP) were measured. Stiffness index (stiffness) was calculated from SOS and BUA. The subjects were asked whether they took regular exercise in their childhood and teen years (in elementary, junior-high, senior-high school and college), the past (20-40 years of age) and present adulthood. Regular calcium intake, smoking habits, alcohol and other beverage consumption and milk consumption were also covered in the questionnaire. The mean NTx values of premenopausal and postmenopausal group were 22.2 and 56.0 nM bone collagen equivalents (BCE)/mM urinary creatinine (Cr), respectively. The group which did not exercise regularly between the ages of 20 and 40 had a higher mean NTx value (40.9 nMBCE/mMCr) than the group which did exercise regularly (22.7 nMBCE/mMCr). In multiple regression analyses, age, stiffness and exercise in past adulthood could explain 43.5% of the NTx variance. For prevention of bone metabolic increases around menopause, habitual exercise in early adulthood seems to be effective.

en-copyright= kn-copyright= en-aut-name=MasatomiChie en-aut-sei=Masatomi en-aut-mei=Chie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ImaiKaori en-aut-sei=Imai en-aut-mei=Kaori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WangDa-Hong en-aut-sei=Wang en-aut-mei=Da-Hong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakataShinji en-aut-sei=Takata en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KiraShohei en-aut-sei=Kira en-aut-mei=Shohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Ibara City Hospital affil-num=6 en-affil= kn-affil=Okayama Saiseikai General Hospital affil-num=7 en-affil= kn-affil=Okayama University en-keyword=N-telopeptides kn-keyword=N-telopeptides en-keyword=bone turnover kn-keyword=bone turnover en-keyword=osteoporosis kn-keyword=osteoporosis en-keyword=menopause kn-keyword=menopause en-keyword=lifestyle kn-keyword=lifestyle END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=3 article-no= start-page=149 end-page=154 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199806 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Serum alpha-fetoprotein levels in healthy Japanese adults. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

With advances in lectin affinity electrophoresis of alpha-fetoprotein (AFP), the detection of significant changes in serum AFP at low levels in cirrhotics has become important for early detection of hepatocellular carcinoma. Serum AFP levels of 616 healthy individuals without abnormal liver function tests or virus markers of hepatitis B and C were determined by enzyme immunoassay with IMx-AFP Dainapack using automated IMx apparatus set at twice the ordinary sensitivity and compared with those of 241 individuals with abnormal liver function tests and/or positive hepatitis virus markers. The coefficient of variation in this assay was less than 10% at AFP levels as low as 0.2 ng/ml with a lower detection limit of 0.1 ng/ml. The AFP level of healthy population showed a Gaussian distribution curve after logarithmic transformation with a median and 2.5-97.5 percentile reference range of 2.2 (0.6-5.6) ng/ml. There was no significant difference in the AFP level between males and females. Individuals with abnormal liver function tests alone showed no significant increase in serum AFP unless they were associated with positive hepatitis virus markers.

en-copyright= kn-copyright= en-aut-name=MatsuiHiroaki en-aut-sei=Matsui en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=RimalNirmal en-aut-sei=Rimal en-aut-mei=Nirmal kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KamakuraKozue en-aut-sei=Kamakura en-aut-mei=Kozue kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UesugiSeiichiro en-aut-sei=Uesugi en-aut-mei=Seiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamamotoHideki en-aut-sei=Yamamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Okayama Universitry affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama Univeristy affil-num=4 en-affil= kn-affil=Okayama Uniiversity affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University en-keyword=?-fetoprotein kn-keyword=?-fetoprotein en-keyword=enzyme immunoassay kn-keyword=enzyme immunoassay en-keyword=healthy japanese adults kn-keyword=healthy japanese adults en-keyword=serum level kn-keyword=serum level en-keyword=reference values kn-keyword=reference values END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=3 article-no= start-page=143 end-page=148 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199806 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Wider Distribution of Salivary-Type Isoamylase Activity as Compared with Pancreatic-Type Isoamylase Activity in Serum: A Study on Young Female Adults en-subtitle= kn-subtitle= en-abstract= kn-abstract=The clinical implications of a wider distribution of salivary type (S-type) isoamylase activity, as compared with that of pancreatic type (P-type) isoamylase activity in the serum of young female adults of 18-23 years old was studied. A high correlation existed between the S-type isoamylase levels in the initial determination and those in the second determination one year after on the same subjects, indicating that the wider distribution of S-type isoamylase level reflects an individual variation. The serum level of S-type isoamylase was highly correlated with the S-type isoamylase activity in saliva. Among the additional factors studied, a weak positive correlation was present between energy intake and the total and S-type isoamylase activities in serum. However, there was no negative correlation between the S-type isoamylase level and body mass index (BMI), which was reported for young male adults. en-copyright= kn-copyright= en-aut-name=NishimuraMasako en-aut-sei=Nishimura en-aut-mei=Masako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Public Health, Okayama University Medical School affil-num=2 en-affil= kn-affil=Department of Public Health, Okayama University Medical School affil-num=3 en-affil= kn-affil=Department of Public Health, Okayama University Medical School en-keyword=isoamylase kn-keyword=isoamylase en-keyword=serum kn-keyword=serum en-keyword=saliva kn-keyword=saliva en-keyword=young female kn-keyword=young female en-keyword=energy intake kn-keyword=energy intake END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=3 article-no= start-page=161 end-page=167 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199806 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Risk analysis of the exposure to GB virus C/hepatitis G virus among populations of intravenous drug users, commercial sex workers and male outpatients at STD clinic in Chiang Mai, Thailand: a cross-sectional case-control study. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

An exposure to GB virus C/hepatitis G virus (GBV-C/HGV) was studied among populations at risk for blood and sexual exposure to analyze risk factor of the transmission of the virus. Blood samples were drawn from 98 intravenous drug users (IVDU), 100 female high-class commercial sex workers (CSW) and 50 male outpatients (MOP) at a sexually transmitted diseases (STD) clinic in Chiang Mai, Thailand. These blood samples were analyzed for GBV-C/HGV RNA; antibodies against second envelope protein of GBV-C/HGV (anti-E2); anti-hepatitis C virus antibody (HCV-Ab); hepatitis B core antibody (HBcAb); and antibodies against human immunodeficiency virus (HIV-Ab). Prevalences of GBV-C/HGV RNA, anti-E2, HCV-Ab, HBcAb and HIV-Ab were 27.6%, 16.3%, 84.7%, 76.5% and 45.0% in IVDU; 0%, 21.5%, 2.0%, 72.0% and 11.0% in CSW; 6.0%, 13.6%, 0%, 64.0% and 14.0% in MOP. While the prevalence of GBV-C/HGV RNA was higher in IVDU than in CSW and MOP, comparable prevalences of anti-E2 among the three populations were found. Intravenous drug injection showed association with GBV-C/HGV RNA, while history of STD associated with anti-E2. In conclusion, intravenous drug injection and STD were found to be risk factors for the previous exposure to GBV-C/HGV, but STD did not increase the risk of the GBV-C/HGV viraemia.

en-copyright= kn-copyright= en-aut-name=SuganumaNarufumi en-aut-sei=Suganuma en-aut-mei=Narufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=WangDa-hong en-aut-sei=Wang en-aut-mei=Da-hong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamamotoHideki en-aut-sei=Yamamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=PhornphukutkulKannika en-aut-sei=Phornphukutkul en-aut-mei=Kannika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=PeerakomeSupatra en-aut-sei=Peerakome en-aut-mei=Supatra kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SitvacharanumKriegsak en-aut-sei=Sitvacharanum en-aut-mei=Kriegsak kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=JittiwutlkarnJaroon en-aut-sei=Jittiwutlkarn en-aut-mei=Jaroon kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama Univeristy affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=chiang Mai University affil-num=7 en-affil= kn-affil=Chiang Mai University affil-num=8 en-affil= kn-affil=Chiang Mai STD Clinic affil-num=9 en-affil= kn-affil=Nothern Drug Dependence Treatment Center en-keyword=GB virus C/hepatitis G virus kn-keyword=GB virus C/hepatitis G virus en-keyword=anti-E2 anti-body kn-keyword=anti-E2 anti-body en-keyword=sexualty transmitted disease kn-keyword=sexualty transmitted disease en-keyword=human immunodeficiency virus kn-keyword=human immunodeficiency virus en-keyword=hepatitis C virus kn-keyword=hepatitis C virus END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=2 article-no= start-page=149 end-page=154 dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=198104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Complete in vitro replication of SV40 DNA and chromatin in saponin-treated permeable cells. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Effect of nicomol on high density lipoprotein (HDL) subfractions, HDL2e and HDL3e, separated by electrophoresis.

en-copyright= kn-copyright= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NagashimaHideo en-aut-sei=Nagashima en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=WatanabeMakoto en-aut-sei=Watanabe en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Kagawa University affil-num=4 en-affil= kn-affil=Okayama Saiseikai General Hospital en-keyword=HDL2 kn-keyword=HDL2 en-keyword= HDL3 kn-keyword= HDL3 en-keyword=HDL cholesterol kn-keyword=HDL cholesterol en-keyword=electrophoresis kn-keyword=electrophoresis en-keyword=Nicomol kn-keyword=Nicomol en-keyword= nicotinic acid derivative. kn-keyword= nicotinic acid derivative. END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue=5 article-no= start-page=293 end-page=299 dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=198011 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Interrelated changes in gamma-glutamyltransferase activity and HDL-cholesterol level in the sera of patients with alcoholic liver injury. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

<p>The levels of HDL-cholesterol and gamma-glutamyltransferase in the sera of 17 patients with alcoholic liver injury were followed after abstinence and compared with those of 11 patients with acute non-alcoholic hepatitis. The activity of gamma-glutamyltransferase decreased in all cases irrespective of the type of liver injuries. The level of HDL-cholesterol also decreased in 11 of 17 cases with alcoholic liver injury. The other alcoholics, in whom HDL-cholesterol level increased or showed no definite change after withdrawal of alcohol, had severe and advanced liver injuries. In non-alcoholic hepatitis, the HDL-cholesterol level increased as normal liver functions were restored except for one case with cholestatic features. It was concluded that alcohol intake can increase HDL-cholesterol level even in the presence of a concomitantly induced hepatic lesion.</p>

en-copyright= kn-copyright= en-aut-name=IdeTakero en-aut-sei=Ide en-aut-mei=Takero kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WatanabeMakoto en-aut-sei=Watanabe en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IzumiMasaki en-aut-sei=Izumi en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SokabeTeruko en-aut-sei=Sokabe en-aut-mei=Teruko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KonoHiroshi en-aut-sei=Kono en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamamotoYoshio en-aut-sei=Yamamoto en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Kagawa University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Yamamoto-Naika-Hospital en-keyword=alcoholic liver injury kn-keyword=alcoholic liver injury en-keyword=HDL-cholesterol kn-keyword=HDL-cholesterol en-keyword= ?-glutamy1-transferase. kn-keyword= ?-glutamy1-transferase. END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=シンバスタチンによる特発性肺動脈性肺高血圧患者の肺動脈平滑筋細胞における血小板由来増殖因子のシグナル伝達に対する抑制効果 kn-title=Inhibitory Effects of Simvastatin on Platelet-derived Growth Factor Signaling in Pulmonary Artery Smooth Muscle Cells From Patients With Idiopathic Pulmonary Arterial Hypertension en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaTetsuya en-aut-sei=Ikeda en-aut-mei=Tetsuya kn-aut-name=池田哲也 kn-aut-sei=池田 kn-aut-mei=哲也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue= article-no= start-page=22 end-page=25 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=200612 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A zoo and animals and a person kn-title=動物園と動物たち､そして人 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AkasakoRyoichi en-aut-sei=Akasako en-aut-mei=Ryoichi kn-aut-name=赤迫良一 kn-aut-sei=赤迫 kn-aut-mei=良一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=(株)池田動物園 END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=1 article-no= start-page=67 end-page=71 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Japanese guideline for management of cervical spondylotis myelopathy kn-title=頚椎症性脊髄症の診療ガイドライン en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TanakaMasato en-aut-sei=Tanaka en-aut-mei=Masato kn-aut-name=田中雅人 kn-aut-sei=田中 kn-aut-mei=雅人 aut-affil-num=1 ORCID= en-aut-name=SugimotoYoshihisa en-aut-sei=Sugimoto en-aut-mei=Yoshihisa kn-aut-name=杉本佳久 kn-aut-sei=杉本 kn-aut-mei=佳久 aut-affil-num=2 ORCID= en-aut-name=MisawaHaruo en-aut-sei=Misawa en-aut-mei=Haruo kn-aut-name=三澤治夫 kn-aut-sei=三澤 kn-aut-mei=治夫 aut-affil-num=3 ORCID= en-aut-name=TakahataTomohiro en-aut-sei=Takahata en-aut-mei=Tomohiro kn-aut-name=高畑智宏 kn-aut-sei=高畑 kn-aut-mei=智宏 aut-affil-num=4 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name=尾﨑敏文 kn-aut-sei=尾﨑 kn-aut-mei=敏文 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学 END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=1 article-no= start-page=9 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication kn-title=DNA 損傷センサーATMキナーゼとChk2はＣ型肝炎ウイルスのRNA複製に必要である en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AriumiYasuo en-aut-sei=Ariumi en-aut-mei=Yasuo kn-aut-name=有海康雄 kn-aut-sei=有海 kn-aut-mei=康雄 aut-affil-num=1 ORCID= en-aut-name=KurokiMisao en-aut-sei=Kuroki en-aut-mei=Misao kn-aut-name=黒木美沙緒 kn-aut-sei=黒木 kn-aut-mei=美沙緒 aut-affil-num=2 ORCID= en-aut-name=DansakoHiromichi en-aut-sei=Dansako en-aut-mei=Hiromichi kn-aut-name=團迫浩方 kn-aut-sei=團迫 kn-aut-mei=浩方 aut-affil-num=3 ORCID= en-aut-name=AbeKenichi en-aut-sei=Abe en-aut-mei=Kenichi kn-aut-name=阿部健一 kn-aut-sei=阿部 kn-aut-mei=健一 aut-affil-num=4 ORCID= en-aut-name=IkedaMasanori en-aut-sei=Ikeda en-aut-mei=Masanori kn-aut-name=池田正徳 kn-aut-sei=池田 kn-aut-mei=正徳 aut-affil-num=5 ORCID= en-aut-name=WakitaTakaji en-aut-sei=Wakita en-aut-mei=Takaji kn-aut-name=脇田隆字 kn-aut-sei=脇田 kn-aut-mei=隆字 aut-affil-num=6 ORCID= en-aut-name=KatoNobuyuki en-aut-sei=Kato en-aut-mei=Nobuyuki kn-aut-name=加藤宣之 kn-aut-sei=加藤 kn-aut-mei=宣之 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍ウイルス学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍ウイルス学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍ウイルス学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍ウイルス学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍ウイルス学 affil-num=6 en-affil= kn-affil=国立感染症研究所　ウイルス第二部 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍ウイルス学 en-keyword=HCV kn-keyword=HCV en-keyword=ATM kn-keyword=ATM en-keyword=Chk2 kn-keyword=Chk2 en-keyword=宿主因子 kn-keyword=宿主因子 en-keyword=DNA 損傷センサー kn-keyword=DNA 損傷センサー END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=5-6 article-no= start-page=795 end-page=835 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Morphology and Classification of Oncogenic Viruses kn-title=腫瘍ウイルスの形態と分類 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Morphologic characteristics of most of known oncogenic viruses, some of which were investigated by us, were described in relation to their oncogenicity and their localizations in tumor tissues. Oncogenic viruses were classified into six groups: type A, B, C, D, E and F. Viruses pertaining to type A were presumably not mature virus particles. Some of them could, however, be immature form or incomplete form of oncogenic virus particles. Viruses belonging to type B, C, D, E, and F were represented by mammary tumor virus of mice, leukemia viruses of mice and chickens, polyoma virus, Shope fibroma virus and Lucke renal adenocarcinoma virus, respectively. They were different in size and shape, and in the mode of development. It was presumed that type B and C viruses were members of the Myxovisus group and type D viruses belonged to Adenovirus and the Papova virus group. It was also believed that type E and F viruses had in general the feature of the Pox virus group and Herpes virus group, respectively. en-copyright= kn-copyright= en-aut-name=HirakiKiyoshi en-aut-sei=Hiraki en-aut-mei=Kiyoshi kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=2 ORCID= en-aut-name=IrinoShozo en-aut-sei=Irino en-aut-mei=Shozo kn-aut-name=入野昭三 kn-aut-sei=入野 kn-aut-mei=昭三 aut-affil-num=3 ORCID= en-aut-name=MiyoshiIsao en-aut-sei=Miyoshi en-aut-mei=Isao kn-aut-name=三好勇夫 kn-aut-sei=三好 kn-aut-mei=勇夫 aut-affil-num=4 ORCID= en-aut-name=SezakiTatsuo en-aut-sei=Sezaki en-aut-mei=Tatsuo kn-aut-name=瀬崎達雄 kn-aut-sei=瀬崎 kn-aut-mei=達雄 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=SuzukiShinya en-aut-sei=Suzuki en-aut-mei=Shinya kn-aut-name=鈴木信也 kn-aut-sei=鈴木 kn-aut-mei=信也 aut-affil-num=7 ORCID= en-aut-name=OhsatoYoshimori en-aut-sei=Ohsato en-aut-mei=Yoshimori kn-aut-name=大里尚司 kn-aut-sei=大里 kn-aut-mei=尚司 aut-affil-num=8 ORCID= en-aut-name=NagamoriTeiichiro en-aut-sei=Nagamori en-aut-mei=Teiichiro kn-aut-name=永森俤一郎 kn-aut-sei=永森 kn-aut-mei=俤一郎 aut-affil-num=9 ORCID= en-aut-name=MoriyaJunichiro en-aut-sei=Moriya en-aut-mei=Junichiro kn-aut-name=守屋純一郎 kn-aut-sei=守屋 kn-aut-mei=純一郎 aut-affil-num=10 ORCID= en-aut-name=MugurumaMasahito en-aut-sei=Muguruma en-aut-mei=Masahito kn-aut-name=六車昌士 kn-aut-sei=六車 kn-aut-mei=昌士 aut-affil-num=11 ORCID= en-aut-name=TakasugiKiyoshi en-aut-sei=Takasugi en-aut-mei=Kiyoshi kn-aut-name=高杉潔 kn-aut-sei=高杉 kn-aut-mei=潔 aut-affil-num=12 ORCID= en-aut-name=DabasakiHiroshi en-aut-sei=Dabasaki en-aut-mei=Hiroshi kn-aut-name=駄場崎浩 kn-aut-sei=駄場崎 kn-aut-mei=浩 aut-affil-num=13 ORCID= en-aut-name=IkedaKazuhiko en-aut-sei=Ikeda en-aut-mei=Kazuhiko kn-aut-name=池田一彦 kn-aut-sei=池田 kn-aut-mei=一彦 aut-affil-num=14 ORCID= affil-num=1 en-affil= kn-affil=岡山大学平木内科 affil-num=2 en-affil= kn-affil=岡山大学平木内科 affil-num=3 en-affil= kn-affil=岡山大学平木内科 affil-num=4 en-affil= kn-affil=岡山大学平木内科 affil-num=5 en-affil= kn-affil=岡山大学平木内科 affil-num=6 en-affil= kn-affil=岡山大学平木内科 affil-num=7 en-affil= kn-affil=岡山大学平木内科 affil-num=8 en-affil= kn-affil=岡山大学平木内科 affil-num=9 en-affil= kn-affil=岡山大学平木内科 affil-num=10 en-affil= kn-affil=岡山大学平木内科 affil-num=11 en-affil= kn-affil=岡山大学平木内科 affil-num=12 en-affil= kn-affil=岡山大学平木内科 affil-num=13 en-affil= kn-affil=岡山大学平木内科 affil-num=14 en-affil= kn-affil=岡山大学平木内科 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=1-3 article-no= start-page=41 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19640330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case report of Epilepsia partialis continua kn-title=持続性部分性てんかんの一症例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We reported a case of epilepsia partialis continua. Movements consist of almost continuous rhythmic jerking which is limited to the right lower limb. Angioma arteriovenosum was seen in the left parietal region on the angiogram of left carotid artery. The clonic jerk of this case was much improved on the anticonvulsants. en-copyright= kn-copyright= en-aut-name=HiramatsuTadashi en-aut-sei=Hiramatsu en-aut-mei=Tadashi kn-aut-name=平松直 kn-aut-sei=平松 kn-aut-mei=直 aut-affil-num=1 ORCID= en-aut-name=YokoyamaShigeo en-aut-sei=Yokoyama en-aut-mei=Shigeo kn-aut-name=横山茂生 kn-aut-sei=横山 kn-aut-mei=茂生 aut-affil-num=2 ORCID= en-aut-name=IkedaHisao en-aut-sei=Ikeda en-aut-mei=Hisao kn-aut-name=池田久男 kn-aut-sei=池田 kn-aut-mei=久男 aut-affil-num=3 ORCID= en-aut-name=YamamotoMasatomo en-aut-sei=Yamamoto en-aut-mei=Masatomo kn-aut-name=山本昌知 kn-aut-sei=山本 kn-aut-mei=昌知 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=9-10 article-no= start-page=431 end-page=434 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19701030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Urinary trichloroethanol and trichloroacetic acid excretion in workers exposed to various concentration of trlchloroethylene in an automobile parts factory (Part 1. Studies on trichloroethylene poisoning) kn-title=三塩化エチレン気中濃度と暴露後の尿中，三塩化エタノール，三塩化酢酸の排泄量との関係 第1報 三塩化工チレン中毒の研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to know the relationship between concentration of trichloroethylne and the amount of urinary trichloroethanol or trichloroacetic acid, average concentration of trichloroethylene inhaled by the workers in an automobile parts factory was measured by Kitagawa detector tube at 20-minute's interval. And urinary trichloroethanol and trichloroacetic acid were determined by Ikeda's oxidation method of chromium trioxide and our direct colorimetric method. The results were as follows. 1. Straight relationship between trichloroethylene concentration in the air and trichloroethanol or trichloroacetic acid in the urine was recognized by Ikeda's method. 2. Urinary trichloroethanol and trichloroacetic acid concentrations in workers exposed to trichloroethylene were determined by both our direct colorimetric method and Ikeda's oxidation method of chromium trioxide. Correlation between urinary trichloroethanol and trichloroacetic acid determined by Ikeda's method and our direct colorimetric method was observed. 泄されるのであろうと言つている.1946年,Forssman,Ahlmark(2)3))はトリクレン蒸気中で働く労働者の訴えと,その尿中三塩化酢酸濃度との関係を見い出し,その75mg/lがトリクレン中毒の警戒すべき限界であると報告した.これに対して,1950年,Frant,Westeadorp(4))は,環境に気中のトリクレン濃度100ppmのもとで働く場合,その尿中には200mg/l濃度の三塩化酢酸を含むと述べられている.現在までは,三塩化酢酸の許容濃度はFrantの成績より75mg/lであるとしている.又,トリクレンの尿中代謝産物には三塩化エタノールのグルクロン酸抱合物もあり,soucek and Vlachova(5))等は1964年に,三塩化エタノールは,三塩化酢酸より排泄量が多く,しかも,排泄速度がはやい事を報告している.著者は実際の作業場で,三塩化エタノール,三塩化酢酸の関係を調べ,気中濃度との関係を求めた.又,三酸化エタノールの定量を池田氏の方法に比べて,簡便な定量を見いだした.そして作業者の尿を用いて,著者等の方法と池田氏の方法との相関を調べた.その成績をここに報告する. en-copyright= kn-copyright= en-aut-name=TakatsukaYoshiko en-aut-sei=Takatsuka en-aut-mei=Yoshiko kn-aut-name=高塚住子 kn-aut-sei=高塚 kn-aut-mei=住子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=81 cd-vols= no-issue=1-2 article-no= start-page=85 end-page=90 dt-received= dt-revised= dt-accepted= dt-pub-year=1969 dt-pub=19690228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Two Cases of Laurence-Moon-Biedl Syndrome -Special Reference to Mental Symptoms- kn-title=Laurence-Moon―Biedl症候群の2例-精神症状を中心に en-subtitle= kn-subtitle= en-abstract= kn-abstract=Two cases of Laurence-Moon-Biedl syndrome were reported with marked mental symptoms. Case 1 had mental defficiency, obesity, polydactylia and Retinitis pigmentosa, and was recognized periodic mental symptoms (repeated alternatively increased psychomotor activity and decreased psychomotor activity). Case 2 had mental defficiency, obesity, polydactylia and Retinitis pigmentosa, and was recognized constant mental symptoms (lacking in spontaneity, mutism, negativism and so on). The mental symptoms of Laurence-Moon-Biedl syndrome seems to be classified as two groups. That is, the first group has constant mental symptoms and the second group has periodic mental symptoms. Our Case 1 belongs to the second group and Case 2 belongs to the first group. en-copyright= kn-copyright= en-aut-name=IkedaHisao en-aut-sei=Ikeda en-aut-mei=Hisao kn-aut-name=池田久男 kn-aut-sei=池田 kn-aut-mei=久男 aut-affil-num=1 ORCID= en-aut-name=HiramatsuIzumi en-aut-sei=Hiramatsu en-aut-mei=Izumi kn-aut-name=平松泉 kn-aut-sei=平松 kn-aut-mei=泉 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=86 cd-vols= no-issue=3-4 article-no= start-page=157 end-page=162 dt-received= dt-revised= dt-accepted= dt-pub-year=1974 dt-pub=19740430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An Autopsy Case of Acoustic Neurinoma with Huge Cysts Showing an Intermittent Clinical Course kn-title=間歇性経過と巨大なcystsで特徴づけられた聴神経腫の1剖検例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A case of acoustic neurinoma with huge cysts was reported clinico-pathologically. A male developed at the age of 30, the left-sided hearing difficulty. At the age of 48, he noted the staggered gait which after a while almost entirely cleared up. At the age of 54, he was again unable to walk because of ataxia. Neurological symptoms at the admission to hospital were almost agreed with those in acoustic neurinoma. The symptoms showed complete remission partly because of medication, but they became worse rapidly again, The patient died from bronchial pneumonia at the age of 60. Autopsy disclosed a tumor with huge cysts at the left cerebello-pontine angle which was diagnosed neurinoma microscopically. The most unusual clinical point lies on the course. It lasted thirty long years and moreover displayed an intermittent course showing remission and exacerbation. Another point of interest is the huge cysts found in the tumor at autopsy. The authors discussed the cases manifestating atypical clinical course and tumors with huge cysts in the literature. en-copyright= kn-copyright= en-aut-name=KurodaShigetoshi en-aut-sei=Kuroda en-aut-mei=Shigetoshi kn-aut-name=黒田重利 kn-aut-sei=黒田 kn-aut-mei=重利 aut-affil-num=1 ORCID= en-aut-name=TateishiJun en-aut-sei=Tateishi en-aut-mei=Jun kn-aut-name=立石潤 kn-aut-sei=立石 kn-aut-mei=潤 aut-affil-num=2 ORCID= en-aut-name=ChudaMasaki en-aut-sei=Chuda en-aut-mei=Masaki kn-aut-name=忠田正樹 kn-aut-sei=忠田 kn-aut-mei=正樹 aut-affil-num=3 ORCID= en-aut-name=IkedaHisao en-aut-sei=Ikeda en-aut-mei=Hisao kn-aut-name=池田久男 kn-aut-sei=池田 kn-aut-mei=久男 aut-affil-num=4 ORCID= en-aut-name=MorisadaAkira en-aut-sei=Morisada en-aut-mei=Akira kn-aut-name=森定諦 kn-aut-sei=森定 kn-aut-mei=諦 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=5 en-affil= kn-affil=倉敷神経科病院 END start-ver=1.4 cd-journal=joma no-vol=81 cd-vols= no-issue=1-2 article-no= start-page=71 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=1969 dt-pub=19690228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of atypical psychosis characterized by periodic stupor, with marked epileptic factors kn-title=著明なてんかん性要因を示し，挿間性昏迷状態をくりかえした非定型精神病の1例 en-subtitle= kn-subtitle= en-abstract=A 16-year old girl. It is said that there was a psychotic case in the relatives on the paternal side of the patient. Her hereditary history remains obscure, but her own history is uneventful. A review was made of this case who had episodes of stuporous state six times, and episodes of delutional-hallucinatory state twice since the age of 13. Clinical and EEG observations were carried out from Nov. 1965 to Aug. 1966, and from March 1967 to July 1967 when she was admitted to our clinic. The results are breifly summarized as follows. The stuporous state which presented mutism and akinesia as the principal symptom was difficult to differentiate from the stupor observable in schizophrenia, and it developed in a day or two at the onset, which lasted for about two weeks and then was alleviated. During this period of episodes she showed no noteworthy symptom of disturbed consciousness and she could recall what had happened to her precisely. Her EEG revealed that paroxysmal abnormal waves characterized by spike wave were inhibited during the stuporous state, but in the stage of remission paroxysmal abnormal waves appeared spontaneously and were activated easily by hyperventilation. This stuporous state could be alleviated transiently by the administration of amytal sodium, and also with a large dose of valium it was improved. On the contrary, anti-epileptic agents had no effect at all on the stuporous state. From the characteristic features of the psychotic state, this case could be construed as a type of atypical psychosis, but paroxysmal abnomality on EEG was similar to that of epilepsy, and so this was the case that had clearly shown to stand on the boundary line between atypical psychosis and epilepsy. Therefore, it seemed that epileptic factors of atypical psychosis should be dicided only after long, continuous observations of the case. Some discussion was made on physiological mechanism inducing a stuporous state. Namely, the mechanism that induced a stuporous state seemed to have a close relation to the excitation of system which tried to inhibit the abnormal EEG, and this system was provably the reticular formation system of the midbrain. kn-abstract=症例は13才女子.患者の7親等にあたる父系に精神病者があつたというが遺伝歴の詳細は不明.既往歴に特記すべきものはない.本症例に招来した前後7回の昏迷状態と,その他幻覚妄想の表面化した,昏迷状態と異なる状態像をあわせ観察し,発病より入院に至る経過,及び前後2回の入院の経過を詳述した.昏迷状態はつよい無動無言を主兆とする分裂病性昏迷と区別のつかないもので,始まりは急で1日を境にして訪れ,2週間前後続き寛解をみる.この間認むべき意識障害はなく,患者は些細な出来事迄すべてを想起できる.前後18回の脳波による継時的観察を行なつた結果,昏迷状態下では,棘波を中心とする発作性異常波は抑制され,寛解期にはこれが出現しやすい傾向を認めた.昏迷状態はAmytal sodiumで,一時的ではあるが劇的に改善され, Valiumの大量内服でも臨床像を改善できた.しかし抗てんかん剤は,むしろ昏迷状態には奏効しなかつた.本症は精神病像からは非定型精神病群の1型としてみられるが,発作波の消長からは,てんかんにみられる所見と同一の傾向を有し,両者を結ぶ1点を鮮やかに示した1例であつた.非定型精神病のてんかん性要因はかかる症例の継時的観察から決定されるべきものであると考えた.その他昏迷状態の出現と,発作波の消長に関し,若干の生理学的推論を試み,考察を加えた. en-copyright= kn-copyright= en-aut-name=HosokawaK. en-aut-sei=Hosokawa en-aut-mei=K. kn-aut-name=細川清 kn-aut-sei=細川 kn-aut-mei=清 aut-affil-num=1 ORCID= en-aut-name=NishimuraS. en-aut-sei=Nishimura en-aut-mei=S. kn-aut-name=西村幸子 kn-aut-sei=西村 kn-aut-mei=幸子 aut-affil-num=2 ORCID= en-aut-name=IkedaH. en-aut-sei=Ikeda en-aut-mei=H. kn-aut-name=池田久男 kn-aut-sei=池田 kn-aut-mei=久男 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学神経精神医学教室 affil-num=2 en-affil= kn-affil=岡山大学神経精神医学教室 affil-num=3 en-affil= kn-affil=岡山大学神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=83 cd-vols= no-issue=9-10 article-no= start-page=311 end-page=317 dt-received= dt-revised= dt-accepted= dt-pub-year=1971 dt-pub=19711030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Five Cases of Low Cerebrospinal Fluid Pressure Syndrome kn-title=低髄液圧症候群の5症例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A report of clinical observation was made on the five cases of low cerebrospinal fluid pressure syndrome that we encountered recently. The age of these patients ranged from 27 to 40 years all being female. As for the causative factors of this condition, the puncture of lumbar spinal fluid appeared to be the cause in one case, the trauma of the head in one, but there could be found not any noteworthy cause for the rest of the cases. The subjective symptomes common to all were headache, nausea and vomiting, and the headache was of the nature to be aggravated on assuming the upright posture. Examinations revealed the low pressure of cerebrospinal fluid was the characteristic feature of this syndrome the maximum of which being 60 mmH(2)O. Otherwise, aside from an increase in the cell counts there could be observed no other noticeable abnormality. As for objective and neurological symptomes no other than bilateral extensor plantar responces and stiffness of the neck could be detected. The administration of hypotonic glucose solution into the vein and physiological saline solution into the subarachnoidal space proved to improve their symptomes and the prognosis was favorable in all. en-copyright= kn-copyright= en-aut-name=IkedaHisao en-aut-sei=Ikeda en-aut-mei=Hisao kn-aut-name=池田久男 kn-aut-sei=池田 kn-aut-mei=久男 aut-affil-num=1 ORCID= en-aut-name=HigashiHirofumi en-aut-sei=Higashi en-aut-mei=Hirofumi kn-aut-name=東博文 kn-aut-sei=東 kn-aut-mei=博文 aut-affil-num=2 ORCID= en-aut-name=EbaraTakashi en-aut-sei=Ebara en-aut-mei=Takashi kn-aut-name=江原嵩 kn-aut-sei=江原 kn-aut-mei=嵩 aut-affil-num=3 ORCID= en-aut-name=KuboShinsuke en-aut-sei=Kubo en-aut-mei=Shinsuke kn-aut-name=久保信介 kn-aut-sei=久保 kn-aut-mei=信介 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学神経精神科 affil-num=2 en-affil= kn-affil=岡山大学神経精神科 affil-num=3 en-affil= kn-affil=岡山大学神経精神科 affil-num=4 en-affil= kn-affil=岡山大学神経精神科 END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=7-8 article-no= start-page=903 end-page=911 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=19770830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Optic neuritis : Studies on the epidemiology and the cerebrospinal fluid kn-title=視神経炎に関する神経学的観察―その疫学と髄液所見― en-subtitle= kn-subtitle= en-abstract=A follow-up study on 60 previously healthy patients with nomosymptomatic optic neuritis, retrobulbar neuritis and idiopathic optic atrophy is reported. 73 per cent of the cases with insidious onset and slow progression were male, and 70 per cent of the cases who was troubled repeatedly on vision were female. In many cases, fever, common cold and overwork had precipitated the optic neuritis. During the following period, 6 patients (15.4 % of cases with acute onset) suffered from the other neurological manifestations, and a half of them (7.7 % ) were diagnosed as multiple sclerosis. Patients, who was diagnosed as retrobulbar neuritis by ophthalmoscopic examination and, who was disturbed on vision bilaterally but unsimultaneously, and repeatedly have an affinity to multiple sclerosis. At the beginning of the disease, a mononuclear pleocytosis was noted in 20.5 per cent of the patients, and elevated total protein level in 35.9 per cent. Polyacrylamide gel disc electrophoresis of the lumbar CSF proteins from 39 patients and the measurement of IgG by single radial immunodiffusion from 10 patients, were carried out. It was characteristic that the electropherogram showed the increase of pre-albumin, fast α(2)-globulin + transferrin and γ-globulin, and the decrease of albumin. These results are similar to those in multiple sclerosis. IgG and IgG % is increased in cases of retrobulbar neuritis, although total protein content is high level in optic neuritis, and then, cases who was disturbed on vision unilaterally or bilaterally but unsimultaneously showed the high level of γ-globulin. Two of 3 patients who subsequently developed to multiple sclerosis, had the CSF findings indistinguishable from those in multiple sclerosis. In one patient, CSF protein level was normal but γ-globulin was increased selectively. Another patient showed the CSF findings with slightly elevated protein level, pleocytosis and increase of IgG and IgG % . kn-abstract=原因不明のmonosymptomaticな視神経炎および視神経萎縮の60例に対し,アンケートによる初診後の経過を調べ,初診時の髄液検査(39例)の結果と合せ検討した.1)症例の発症年令は,思春期前および初老期後は著しく少なく,性別は男女同数だが,経過別にみると,緩徐発症慢性経過は男性に,急激発症反復は女性に多い.2)発症誘因に,発熱・感冒・過労などがあり, MSに類似する.3)後に神経症状を呈したのは6例で,急激発症例の15.4 % にあたる.うちMSへ移行したのは3例7.7 % である.球後視神経炎のみに限ると, 18例中3例16.7 % である.4)眼底所見,罹患側,臨床経過などを分析すると,各々,球後視神経炎,両側非同時性,急激発症反復型がMSへの指向を示す.5) 髄液では,軽度細胞数増多,軽度蛋白量増加を示す.蛋白分画ではalbuminの減少,fast α(2)-globulin＋transferrinの増加,γ-globulinの増加の他pre-albuminの増加がうかがえた.6)眼底所見別にみると,蛋白量は視神経炎で高値であるのに対し,IgG,IgG % は球後視神経炎で増加を示す.罹患側別にみると,片側性および両側非同時性においてγ-globulinの増加を認む.経過別にみると反復型およびMS移行群で,蛋白量, γ-globulinの増加を示す,又MS移行の3例中2例で,初回発作時にMS的髄液所見(γ-globulinの選択的増加, IgG, IgG % の増加)を示した. en-copyright= kn-copyright= en-aut-name=HayabaraToshiyuki en-aut-sei=Hayabara en-aut-mei=Toshiyuki kn-aut-name=早原敏之 kn-aut-sei=早原 kn-aut-mei=敏之 aut-affil-num=1 ORCID= en-aut-name=YabukiSeiso en-aut-sei=Yabuki en-aut-mei=Seiso kn-aut-name=矢吹聖三 kn-aut-sei=矢吹 kn-aut-mei=聖三 aut-affil-num=2 ORCID= en-aut-name=FukuiHideaki en-aut-sei=Fukui en-aut-mei=Hideaki kn-aut-name=福井秀明 kn-aut-sei=福井 kn-aut-mei=秀明 aut-affil-num=3 ORCID= en-aut-name=ChudaMasaki en-aut-sei=Chuda en-aut-mei=Masaki kn-aut-name=忠田正樹 kn-aut-sei=忠田 kn-aut-mei=正樹 aut-affil-num=4 ORCID= en-aut-name=NambaReiko en-aut-sei=Namba en-aut-mei=Reiko kn-aut-name=難波玲子 kn-aut-sei=難波 kn-aut-mei=玲子 aut-affil-num=5 ORCID= en-aut-name=IkedaHisao en-aut-sei=Ikeda en-aut-mei=Hisao kn-aut-name=池田久男 kn-aut-sei=池田 kn-aut-mei=久男 aut-affil-num=6 ORCID= en-aut-name=OtsukiSaburo en-aut-sei=Otsuki en-aut-mei=Saburo kn-aut-name=大月三郎 kn-aut-sei=大月 kn-aut-mei=三郎 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=国立岡山療養所・神経内科 affil-num=2 en-affil= kn-affil=高知県立中央病院・神経科 affil-num=3 en-affil= kn-affil=岡山大学・神経精神医学教室 affil-num=4 en-affil= kn-affil=岡山大学・神経精神医学教室 affil-num=5 en-affil= kn-affil=国立岡山療養所・神経内科 affil-num=6 en-affil= kn-affil=岡山大学・神経精神医学教室 affil-num=7 en-affil= kn-affil=岡山大学・神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=3-4 article-no= start-page=407 end-page=417 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=19770430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Endemic survey on Concinnum ten (Yamaguti, 1939) Travassos, 1944 among some wild animals kn-title=タヌキ,テン,アナグマ,イタチの膵管に寄生を認めたConcinnum ten (Yamaguti, 1939) Travassos, 1944について en-subtitle= kn-subtitle= en-abstract= kn-abstract=An investigation on the helminths of wild animals (Martes melampus, Meles meles, Mustela sivirica, Myocastor coypus, Nyctereutes procyonoides and Vulpes vulpes) caught in the systems of the Chugoku mountains of Hiroshima and Okayama prefectures was done from December in 1970 to October in 1974. The worms, genus Concinnum, were found from the pancreatic duct of Nyctereutes procyonoides, Martes melampus, Meles meles and Mustela sivirica. The parasitic rate of Concinnum in Martes melampus is 100 % (the average number of parasites is about 3000), in Nyctereutes procyonoides 23.8% (40), in Mustela sibirica 20% (225) and in Meles meles 50% (9). The parasites were fixed with Schaudin's solution while compressed between slide glasses, stained with carmine solution and observed with the light microscope. All of the worms were identified with Concinnum ten (Yamaguti, 1939) Travassos, 1944 according to the measurement. The present paper is the first report showing that Concinnum ten was found from Meles meles and Mustela sibirica, and that these animals are also the natural final hosts of Concinnum ten. en-copyright= kn-copyright= en-aut-name=SaitoTetsuro en-aut-sei=Saito en-aut-mei=Tetsuro kn-aut-name=斉藤哲郎 kn-aut-sei=斉藤 kn-aut-mei=哲郎 aut-affil-num=1 ORCID= en-aut-name=TomitaSeiichiro en-aut-sei=Tomita en-aut-mei=Seiichiro kn-aut-name=富田精一郎 kn-aut-sei=富田 kn-aut-mei=精一郎 aut-affil-num=2 ORCID= en-aut-name=IkedaSyuji en-aut-sei=Ikeda en-aut-mei=Syuji kn-aut-name=池田周二 kn-aut-sei=池田 kn-aut-mei=周二 aut-affil-num=3 ORCID= en-aut-name=SakumotoDaigoro en-aut-sei=Sakumoto en-aut-mei=Daigoro kn-aut-name=作本台五郎 kn-aut-sei=作本 kn-aut-mei=台五郎 aut-affil-num=4 ORCID= en-aut-name=TonguYasumasa en-aut-sei=Tongu en-aut-mei=Yasumasa kn-aut-name=頓宮廉正 kn-aut-sei=頓宮 kn-aut-mei=廉正 aut-affil-num=5 ORCID= en-aut-name=SuguriSetsuo en-aut-sei=Suguri en-aut-mei=Setsuo kn-aut-name=村主節雄 kn-aut-sei=村主 kn-aut-mei=節雄 aut-affil-num=6 ORCID= en-aut-name=ItanoKazuo en-aut-sei=Itano en-aut-mei=Kazuo kn-aut-name=板野一男 kn-aut-sei=板野 kn-aut-mei=一男 aut-affil-num=7 ORCID= en-aut-name=InatomiSeiiti en-aut-sei=Inatomi en-aut-mei=Seiiti kn-aut-name=稲臣成一 kn-aut-sei=稲臣 kn-aut-mei=成一 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部寄生虫学教室 END start-ver=1.4 cd-journal=joma no-vol=91 cd-vols= no-issue=9-10 article-no= start-page=1317 end-page=1332 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=19791030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental study of safety limits in differential hypothermia Part 2. Metabolic effects on normal rabbit brains kn-title=Differential Hypothermia処置の安全限界に関する実験的研究 第2編 家兎正常脳の代謝への影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Differential hypothermia (D.H.) treatment was performed on normal rabbit brains and the associated changes in cerebral metabolism were observed in series. Under generalized body hypothermia (rectal temperature; 23℃), a portion of normal brain was maintained at normothermia (37±1℃) by heating with microwave irradiation (2.45GHz). Brain tissues were sampled as follows; before treatment, at the beginning, 3, 6 and 10 hours later, and finally 12 and 36 hours after completion of the 10 hour-treatment. Five rabbits were studied in each group to be 35 as a total sum. In each rabbit, two samples; one from the normothermic portion and one from the hypothermic portion, were obtained. By using enzymatic analysis, six glycolytic metabolites (glucose, glucose-6-phosphate, fructose-1,6-diphosphate, dihydroxyacetone phosphate, pyruvate, lactate) and three adenine nucleotides (ATP, ADP, AMP) were investigated quantitatively. From these results, the ratio of lactate and pyruvate (L/P ratio) and energy charge potential (ECP) were calculated. Before the treatment, the L/P ratio was 26.4 and ECP was 0.921. Up to 6 hours after the beginning, the metabolic status in the normothermic portion was relatively higher than the hypothermic portion. Namely, L/P ratio and ECP in the normothermic portion reached 27.6 and 0.953 respectively. On the completion of the 10 hour-treatment, however, glucose decreased considerably. While G6P increased markedly associated with a L/P ratio of 47.5. Similarly ATP was decreased, while ADP and AMP were increased, therefore ECP decreased to 0.873. These data indicated tissue hypoxia. On the other hand, 36 hours after the treatment, the L/P ratio recovered completely to 18.7, ECP also recovered to 0.901. These results indicated that metabolism in the normothermic portion was smooth up to 6 hours duration of treatrent, although it was constantly higher than the hypothermic portion. On the completion of the 10 hour-treatment, increase of glycolysis by tissue hypoxia and failure of energy metabolism were observed. However, these changes were considered still reversible because the results obtained after the treatment indicated reasonable recovery. Therefore it was suggested that 10 hour-differential hypothermia treatment on the normal rabbit brains was safe from a viewpoint of glycolytic and energy metabolism. en-copyright= kn-copyright= en-aut-name=IkedaKomei en-aut-sei=Ikeda en-aut-mei=Komei kn-aut-name=池田幸明 kn-aut-sei=池田 kn-aut-mei=幸明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学脳神経外科学教室 en-keyword=differential hypothermia kn-keyword=differential hypothermia en-keyword=normal brain kn-keyword=normal brain en-keyword=glucose kn-keyword=glucose en-keyword=adenine nucleotides kn-keyword=adenine nucleotides en-keyword=metabolic changes kn-keyword=metabolic changes END start-ver=1.4 cd-journal=joma no-vol=91 cd-vols= no-issue=9-10 article-no= start-page=1301 end-page=1316 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=19791030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental study of safety limits in differential hypothermia Part 1. Heating of brain by microwave irradiation kn-title=Differential Hypothermia処置の安全限界に関する実験的研究 第1編Microwave照射による脳加温に関して en-subtitle= kn-subtitle= en-abstract= kn-abstract=Differential hypothermia (D.H.) treatment (preservation of brain tumor at normothermia during generalized body hypothermia) for the treatment of human brain tumors requires the tumor to be heated throughly and maintained for the necessary time. The normal portion of brain has to be protected during and after the treatment. Microwave (MW) seemed the most suitable heating method, so its effects on the normal brain of dogs were studied. During MW irradiation, the thermistor-probe showed higher temperatures erroneously. When the probe was covered by aluminium foil, the measurement error was less than 0.2℃ as long as the probe was in the brain. This method sufficiently heated the brain under generalized hypothermia down to 2 cm in depth from the surface. The highest temperature was recorded between 0.5 cm and 1 cm in depth and was easily controlled by the output of MW. On the other hand, aluminium foil blocked MW irradiation completely, therefore the irradiation field possibly protected the normal portion. To study the safety limits of heating by MW irradiation, two groups of rabbits maintained at different temperatures (37℃ and 40℃) were prepared. Following D.H. treatment for 5 hours in each group, the rabbit brains were examined histologically. The results showed minimal brain damage by MW irradiation in the 37℃ group. In the 40℃ group, heat necrosis was constantly observed as well as stagnation of vessels and perivascular cuffing of round cells. From these findings, it was concluded that MW was useful as a heating method during D.H. treatment. The safety limit of heating was up to normothermia. en-copyright= kn-copyright= en-aut-name=IkedaKomei en-aut-sei=Ikeda en-aut-mei=Komei kn-aut-name=池田幸明 kn-aut-sei=池田 kn-aut-mei=幸明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学脳神経外科学教室 en-keyword=differential hypothermia kn-keyword=differential hypothermia en-keyword=microwave irradiation kn-keyword=microwave irradiation en-keyword=normal brain kn-keyword=normal brain en-keyword=histopathology kn-keyword=histopathology END start-ver=1.4 cd-journal=joma no-vol=92 cd-vols= no-issue=1-2 article-no= start-page=85 end-page=92 dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=19800228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A survey of inpatient alcoholics in Okayama Prefecture kn-title=岡山県におけるアルコール症入院患者の実態 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A survey of inpatient alcoholics in Okayama Prefecture was carried out on September 1, 1977. Questionnaires for each alcoholic were sent to the psychiatrists of 23 psychiatric hospitals and wards (the total number of psychiatric beds was 4591). Psychiatrists from 21 hospitals (93.9% of the total beds) supplied data. There were 4198 psychiatric inpatients, of whom 230 (5.5%) were alcoholics. Of these alcoholics, 14 were women (6.1% of all alcoholics). Marked differences were found among the hospitals concerning the number of inpatient alcoholics. The number of senile alcoholics over 60 was high (49 persons, 21.4%) and many inpatient alcoholics (102 persons, 44.3%) continued admission for more than one year. The hospital bills of 110 alcoholics (47.8%) were paid by Seikatsuhogo (financial support by the Welfare Office) and obligatory admissions were only 3 (1.3%) of the total alcoholics. 83 of the guardians (36.1%) were spouses and 20 (8.7%) were mayors or village heads. 30.4% of them remained divorced. Thus, inpatient alcoholics had handicaps in family and economical backgrounds, and it is necessary to carry on treatment sufficiently supported by social work. en-copyright= kn-copyright= en-aut-name=SuwakiH en-aut-sei=Suwaki en-aut-mei=H kn-aut-name=洲脇寛 kn-aut-sei=洲脇 kn-aut-mei=寛 aut-affil-num=1 ORCID= en-aut-name=HoriiS en-aut-sei=Horii en-aut-mei=S kn-aut-name=堀井茂男 kn-aut-sei=堀井 kn-aut-mei=茂男 aut-affil-num=2 ORCID= en-aut-name=IkedaH en-aut-sei=Ikeda en-aut-mei=H kn-aut-name=池田久男 kn-aut-sei=池田 kn-aut-mei=久男 aut-affil-num=3 ORCID= en-aut-name=OtsukiS en-aut-sei=Otsuki en-aut-mei=S kn-aut-name=大月三郎 kn-aut-sei=大月 kn-aut-mei=三郎 aut-affil-num=4 ORCID= en-aut-name=NishiiY en-aut-sei=Nishii en-aut-mei=Y kn-aut-name=西井保行 kn-aut-sei=西井 kn-aut-mei=保行 aut-affil-num=5 ORCID= en-aut-name=TakahashiS en-aut-sei=Takahashi en-aut-mei=S kn-aut-name=高橋茂 kn-aut-sei=高橋 kn-aut-mei=茂 aut-affil-num=6 ORCID= en-aut-name=FujimotoA en-aut-sei=Fujimoto en-aut-mei=A kn-aut-name=藤本明 kn-aut-sei=藤本 kn-aut-mei=明 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=高知医科大学神経精神医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=3 en-affil= kn-affil=高知医科大学神経精神医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=5 en-affil= kn-affil=高知医科大学神経精神医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部神経精神医学教室 en-keyword=アルコール症 kn-keyword=アルコール症 en-keyword=実態調査 kn-keyword=実態調査 en-keyword=岡山県 kn-keyword=岡山県 en-keyword=精神病院 kn-keyword=精神病院 END start-ver=1.4 cd-journal=joma no-vol=94 cd-vols= no-issue=7-8 article-no= start-page=721 end-page=727 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of stepwise extraction of nonhistone proteins and H1 histone on template activity of chromatin and on digestion of chromatin by micrococcal nuclease kn-title=非ヒストン蛋白質およびH1ヒストン除去のクロマチンの鋳型活性とヌクレアーゼ消化性への影響 en-subtitle= kn-subtitle= en-abstract=Changes in the structure and function of Ehrlich ascites tumor cell chromatin induced by extracting with 0.15 to 0.6 M NaCl were analyzed. H1 histone was selectively extracted from chromatin by treating with 0.6 M NaCl. The higher the salt concentration that was applied to the chromatin, the larger the amount of proteins that was extracted, and the higher the template activity and micrococcal nuclease sensitivity that were attained. The chromatin reconstituted from H1 histone and H1-depleted chromatin showed reduced template activity and reduced nuclease sensitivity. The size of nuclease-digested DNA fragments (nucleosome monomer) were identical regardless of the depletion of H1 histone and some non-histone proteins. kn-abstract=真核細胞のクロマチンは,DNA,ヒストン,非ヒストン蛋白質の複合体であり,その基本構造は,4種のヒストン(H2A,H2B,H3,H4)の各2分子が会合した8量体(ヒストンコア)にDNAが約1.75回巻きついたヌクレオソームコアが連結DNAで数珠玉状に連なったヌクレオソーム構造の繰り返しであることが知られている(1)).またH1ヒストンはヌクレオソーム間の連結DNAに,クロマチンを折りたたむようについていると考えられている(2,3)).非ヒストン蛋白質の分子種は数百にも及び,生物種や細胞分化の過程で特異的な変化を示すことからDNAやRNA合成の調節の主役をなすと考えられている(4～6)).ヒストンと非ヒストン蛋白質を選択的に核またはクロマチンから除去することによるクロマチンの形態変化の電顕観察(7)),転写鋳型活性への影響(5,6,8,9)),micrococcal nuclease消化への影響(10～12))を研究することにより,ヒストン,非ヒストン蛋白質の機能の研究がされている.特にH1ヒストン除去によるクロマチンの構造と機能の変化の研究がよく行なわれている.これらの研究でH1除去の転写活性に与える影響については,促進的に働くとする報告(6,9))とH1除去では影響なくクロマチンにH1を添加することにより転写活性を抑制できるとする報告(8))とがある.またH1除去のmicrococcal nucleaseによるクロマチンDNAの消化に与える影響についても,消化DNA断片の大きさに変化があるという報告(10))とDNA断片の大きさに変化はなく,単にヌクレアーゼ感受性が高まるだけであるとする報告(11,12))とがある.本研究は,塩(NaCl)処理によりクロマチンからH1ヒストン,非ヒストン蛋白質を除去し,それによるクロマチン構造と機能の変化を転写鋳型活性とmicrococcal nuclease消化性の面から研究した. en-copyright= kn-copyright= en-aut-name=IrisawaMinoru en-aut-sei=Irisawa en-aut-mei=Minoru kn-aut-name=入澤實 kn-aut-sei=入澤 kn-aut-mei=實 aut-affil-num=1 ORCID= en-aut-name=IkedaShogo en-aut-sei=Ikeda en-aut-mei=Shogo kn-aut-name=池田正五 kn-aut-sei=池田 kn-aut-mei=正五 aut-affil-num=2 ORCID= en-aut-name=OdaTakuzo en-aut-sei=Oda en-aut-mei=Takuzo kn-aut-name=小田琢三 kn-aut-sei=小田 kn-aut-mei=琢三 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部癌源研究施設生化学部 affil-num=2 en-affil= kn-affil=岡山大学医学部癌源研究施設生化学部 affil-num=3 en-affil= kn-affil=岡山大学医学部癌源研究施設生化学部 en-keyword=クロマチン kn-keyword=クロマチン en-keyword=RNAポリメラーゼ kn-keyword=RNAポリメラーゼ en-keyword=ヌクレアーゼ kn-keyword=ヌクレアーゼ END start-ver=1.4 cd-journal=joma no-vol=93 cd-vols= no-issue=1-2 article-no= start-page=143 end-page=152 dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=19810228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The data processing system in the central division of surgery kn-title=中央手術部における管理情報の処理 en-subtitle= kn-subtitle= en-abstract=In order to apply computer technology to analysing information obtained from operating rooms, a special code system for processing data was established. The installation of this system should be easy for nurses and clerks to use. We decided on the codes for diseases and operations by consulting the "International Classification of Diseases" and the "Operation Name Classification of Japanese Governmental Health Insurance Fund". Using this system, we analysed 3879 cases of surgery performed at our hospital during the year 1978. This code system could be applied practically to data processing for management of the central division of surgery. Only a small number of codes covered most of the cases treated by surgical operations. kn-abstract=中央手術部における過去のデータを詳細に分析し,その結果をふまえて合理的な手術部の運営方法に改めるべきであると考えた.そこで昭和53年度の全手術患者3,879例について,手術明細表に記載されている事項をコンピュータに入力し,必要に応じて種々のデータが引き出せるようなシステムを試作した.今までこのような解析ができなかった理由は,病名および手術名があまりに多岐にわたっていてコード化することが困難であったからである.今回改訂発表されたInternational Classification of Diseasesの日本語版は,あらゆる病名を網羅していて使いやすく実用的であることが確認できた.またわが国の社会保険診療報酬規定の甲表区分番号による術名コードも,普遍性と実用性の面ですぐれていることが実証できた. en-copyright= kn-copyright= en-aut-name=ArataTakiji en-aut-sei=Arata en-aut-mei=Takiji kn-aut-name=新太喜治 kn-aut-sei=新 kn-aut-mei=太喜治 aut-affil-num=1 ORCID= en-aut-name=WatanabeYasuhiro en-aut-sei=Watanabe en-aut-mei=Yasuhiro kn-aut-name=渡辺泰宏 kn-aut-sei=渡辺 kn-aut-mei=泰宏 aut-affil-num=2 ORCID= en-aut-name=MurakamiTaiji en-aut-sei=Murakami en-aut-mei=Taiji kn-aut-name=村上泰治 kn-aut-sei=村上 kn-aut-mei=泰治 aut-affil-num=3 ORCID= en-aut-name=MaedaNaotoshi en-aut-sei=Maeda en-aut-mei=Naotoshi kn-aut-name=前田直俊 kn-aut-sei=前田 kn-aut-mei=直俊 aut-affil-num=4 ORCID= en-aut-name=IkedaYuji en-aut-sei=Ikeda en-aut-mei=Yuji kn-aut-name=池田祐治 kn-aut-sei=池田 kn-aut-mei=祐治 aut-affil-num=5 ORCID= en-aut-name=TomitaToshio en-aut-sei=Tomita en-aut-mei=Toshio kn-aut-name=冨田校郎 kn-aut-sei=冨田 kn-aut-mei=校郎 aut-affil-num=6 ORCID= en-aut-name=MitsuokaToshito en-aut-sei=Mitsuoka en-aut-mei=Toshito kn-aut-name=光岡利人 kn-aut-sei=光岡 kn-aut-mei=利人 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院中央手術部 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院中央手術部 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院中央手術部 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院中央手術部 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院中央手術部 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院中央手術部 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院中央手術部 en-keyword=手術室 kn-keyword=手術室 en-keyword=情報処理 kn-keyword=情報処理 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=宿主免疫系を介するテロメラーゼに特異的なウイルス療法に関する新しい血管新生阻害効果 kn-title=A Novel Antiangiogenic Effect for Telomerase-Specific Virotherapy through Host Immune System en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaYoshihiro en-aut-sei=Ikeda en-aut-mei=Yoshihiro kn-aut-name=池田義博 kn-aut-sei=池田 kn-aut-mei=義博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=97 cd-vols= no-issue=5-6 article-no= start-page=419 end-page=428 dt-received= dt-revised= dt-accepted= dt-pub-year=1985 dt-pub=19850630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Molecular cloning of the SV40 small t antigen gene and purification of the antigen kn-title=SV40小型腫瘍抗原遺伝子のクローン化と抗原の精製 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The simian virus 40 (SV40) DNA fragment encoding small t antigen was cloned with expression vector pUC8 for the purification of small t-antigen. Small t antigen produced in Escherichia coli was a hybrid protein of 22,000 daltons which comprised about 6% of the total protein. Hybrid small t antigen maintained antigenic activity which was examined by Western-blotting and enzyme-linked immunoassay. Hybrid small t antigen was extracted from E. coli with urea and purified from a small t-antigen band in SDS-polyacrylamide gel. The purified antigen maintained antigenic activity. en-copyright= kn-copyright= en-aut-name=IkedaShogo en-aut-sei=Ikeda en-aut-mei=Shogo kn-aut-name=池田正五 kn-aut-sei=池田 kn-aut-mei=正五 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部癌源研究施設生化学部門 en-keyword=SV40 t 抗原 kn-keyword=SV40 t 抗原 en-keyword=遺伝子のクローン化 kn-keyword=遺伝子のクローン化 en-keyword=発現ベクター kn-keyword=発現ベクター en-keyword=ウエスタン・ブロッティング kn-keyword=ウエスタン・ブロッティング END start-ver=1.4 cd-journal=joma no-vol=99 cd-vols= no-issue=9-10 article-no= start-page=1071 end-page=1081 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=19871031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Chronic effects of the Ca(++) channel blocker verapamil on monoamine release and metabolism in discrete rat brain regions: Comparison with the effects of methamphetamine and reserpine kn-title=カルシウムチャンネル阻害剤verapamilの中枢モノアミン伝達物質の放出ならびに代謝に及ぼす作用 : methamphetamineおよびreserpineとの比較 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effects of chronic treatment with verapamil(VP) on monoamine release and metabolism in rat brain in vivo were compared with the effects of methamphetamine(MAP) and reserpine(RES). These drugs were administered to rats in drinking water for two weeks. The contents of monoamines (DA and 5HT) and their major metabolites(DOPAC, HVA and 5HIAA) in eight discrete brain regions were measured by HPLC-ECD. After treatment with VP, DA levels decreased in the nucleus accumbens(N.ACC) and the suprachiasmatic nucleus(SCN), but no significant changes were demonstrated in the metabolites(DOPAC, HVA). 5HT levels decreased in the N.ACC, SCN and amygdara(AMY), and 5HIAA levels decreased in the raphe dorsalis(RD). GABA contents were increased in the N.ACC. After treatment with MAP, DA levels decreased in the N.ACC, striatum(STR) and ventro-medial hypothalamic regions(VMH). No significant change was shown in the metabolites. 5HT contents decreased in the N.ACC, STR, AMY, VMH and RD. 5HIAA contents decreased significantly in the RD. After treatment with RES, DA levels decreased in the N.ACC, STR and SCN. HVA contents decreased in the N.ACC and SCN, though they increased in the LH and SN. 5HT levels decreased in the N.ACC, SCN, AMY and RD. High 5HIAA concentrations were found in the N.ACC, STR, LH and VMH. DA, DOPAC and HVA levels were reduced more in several regions by co-administration of VP and MAP than by MAP treatment alone. DA was lowered more in the RD and HVA was lowered more in several regions by co-administration of VP and RES than by RES treatment alone. The well known locomotor hyperactivity induced by MAP was enhanced by VP. The present study suggests that there are at least two classes of voltage-gated calcium channels in the central nervous system related to the release of monioamines, one sensitive to VP and other not. In addition, chronic VP treatment may have an inhibitory effect on the release and synthesis of monoamines. en-copyright= kn-copyright= en-aut-name=IkedaMasaaki en-aut-sei=Ikeda en-aut-mei=Masaaki kn-aut-name=池田正明 kn-aut-sei=池田 kn-aut-mei=正明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳代謝研究施設病態生化学部門 en-keyword=Verapamil kn-keyword=Verapamil en-keyword=Ca(2+)-channel kn-keyword=Ca(2+)-channel en-keyword=Methamphetamine kn-keyword=Methamphetamine en-keyword=Reserpine kn-keyword=Reserpine en-keyword=Monoamine release kn-keyword=Monoamine release END start-ver=1.4 cd-journal=joma no-vol=99 cd-vols= no-issue=9-10 article-no= start-page=1063 end-page=1069 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=19871031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on a human malignant thymoma Part 2. Heterotransplantation of a human malignant thymoma (epithelial type) cell line into hamsters kn-title=ヒト悪性胸腺腫に関する研究　第2編　ヒト上皮型悪性胸腺腫細胞株(MT-TY株)のハムスターへの異種移植 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A continuous cell line, which was designated as MT-TY, was established from an explant culture of human malignant thymoma (epithelial type) in our laboratory. In the present study, for the purpose of making an animal model of human malignant thymoma, MT-TY cells were transplanted into antilymphocyte serum-treated newborn hamsters. The MT-TY line was serially transplanted for 7 passages. When 1.2-11.0×10(6) cells were inoculated intraperitoneally, all of the 22 experimental animals developed invasive tumors. Of the 22 hamsters, ascites and pulmonary metastases were found in 16 and 4 hamsters, respectively. Histological characteristics of the tumors in hamsters were similar to those of epithelial type of human malignant thymoma. This animal model would be useful for various studies of human malignant thymoma. en-copyright= kn-copyright= en-aut-name=IkedaHiromasa en-aut-sei=Ikeda en-aut-mei=Hiromasa kn-aut-name=池田裕政 kn-aut-sei=池田 kn-aut-mei=裕政 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=human malignant thymoma cell line kn-keyword=human malignant thymoma cell line en-keyword=heterotransplantation kn-keyword=heterotransplantation END start-ver=1.4 cd-journal=joma no-vol=99 cd-vols= no-issue=9-10 article-no= start-page=1053 end-page=1061 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=19871031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on a human malignant thymoma Part 1. Establishment and characterization of a human malignant thymoma (epithelial type) cell line kn-title=ヒト悪性胸腺腫に関する研究　第1編　ヒト上皮型悪性胸腺腫細胞株(MT-TY株)の培養樹立とその性状 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A permanent cell line, MT-TY, has been successfully established in continuous culture from a metastatic lymph node of a patient with malignant thymoma (epithelial type). Most of the MT-TY cells grew in suspension with formation of cell clumps. The doubling time of the cells was 36 hours and the modal chromosome number was 68. The MT-TY line is considered to have originated from donor's thymoma cells on the basis of cytogenetic, morphological and chromosomal features. en-copyright= kn-copyright= en-aut-name=IkedaHiromasa en-aut-sei=Ikeda en-aut-mei=Hiromasa kn-aut-name=池田裕政 kn-aut-sei=池田 kn-aut-mei=裕政 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科教室 en-keyword=human malignant thymoma kn-keyword=human malignant thymoma en-keyword=epithelial type kn-keyword=epithelial type en-keyword=tissue culture kn-keyword=tissue culture END start-ver=1.4 cd-journal=joma no-vol=99 cd-vols= no-issue=5-6 article-no= start-page=681 end-page=690 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=19870630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Inhibition of anaphylactic histamine release from rat peritoneal mast cells by disodium cromoglycate, 6, 7-dihydro-6, 8, 8, 10-tetramethyl-8H-pyrano-[3, 2-G] chromon-2-carboxylic acid (EAA) and tranilast kn-title=ラット腹腔肥満細胞からのアナフィラキシー性histamine遊離に対するdisodium cromoglycate, 6, 7-dihydro-6, 8, 8, 10-tetramethyl-8H-pyrano[3, 2-G]chromon-2-carboxylic acid(EAA)およびtranilastの抑制効果 -細胞外Ca(2+)の影響および交叉タキフィラキシーの成立- en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the modes of the inhibitory action of DSCG, EAA and tranilast on histamine release, the effects of these drugs were studied on anaphylactic histamine release from rat peritoneal mast cells passively sensitized with mouse anti-ovalbumin serum. DSCG had a potent and dose-dependent inhibitory effect on the release in ordinary Hanks' medium, whereas its activity was far weaker in the absence of Ca(2+). No marked differences were observed in the inhibitory activities of EAA and tranilast, irrespective of the presence or absence of extracellular Ca(2+). The inhibitory effects of the three drugs declined with prolongation of time of drug treatment before antigen challenge (development of tachyphylaxis). Once mast cells were made tachyphylactic to one of the three drugs, such cells showed markedly decreased responses to the other drugs (development of cross-tachyphylaxis). These results suggest that some common processes are involved in the mechanism of inhibition of histamine release by these drugs. It is possible that these drugs bind to the same specific sites on the surface of mast cells. en-copyright= kn-copyright= en-aut-name=IkedaShigeki en-aut-sei=Ikeda en-aut-mei=Shigeki kn-aut-name=池田滋樹 kn-aut-sei=池田 kn-aut-mei=滋樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部薬理学教室 en-keyword=histamine遊離 kn-keyword=histamine遊離 en-keyword=肥満細胞 kn-keyword=肥満細胞 en-keyword=抗アレルギー薬 kn-keyword=抗アレルギー薬 en-keyword=カルシウムイオン kn-keyword=カルシウムイオン en-keyword=タキフィラキシー kn-keyword=タキフィラキシー END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=1 end-page=19 dt-received= dt-revised= dt-accepted= dt-pub-year=1949 dt-pub=194912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=放射能泉に関する研究-9〜19- en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大島良雄 kn-aut-sei=大島 kn-aut-mei=良雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=1 article-no= start-page=85 end-page=90 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Nursing students' images of the elderly before and after a two-week nursing practice kn-title=看護学生の老人施設実習前後の老人イメージ en-subtitle= kn-subtitle= en-abstract=This study investigated how nursing students perceived the elderly living in a nursing home for the elderly. Testing was done both before and after they experienced a two-week nursing practice at the nursing home. Three findings were obtained. (1) The students regarded the elderly not only as more humorous and vital but also less experienced, peaceful, and realistic before than after experiencing the practice. (2) Over a third of the students named humorous/not humorous as an item for which they experienced a marked change in image of the elderly. (3) The students generally regarded the elderly as being experienced, warm, bored, weak, and lonely. The findings indicate that the nursing practice provided the students with an opportunity to form better and realistic images of the elderly. kn-abstract=2週間の特別養護老人ホームの実習前及び実習後の学生の老人イメージを20項目の尺度を用いて調査した｡その結果,以下のことが明らかになった｡ 1. 実習後のイメージの平均得点は,｢ユーモアのない｣から｢ユーモアのある｣へ,｢生気のない｣から｢生気のある｣へと好ましい方向へ上昇し,一方｢経験に富む｣,｢穏やかな｣,｢現実的な｣は好ましくない方向へ変化した｡ 2. 3分の1以上の学生が実習後に特にイメージが変化した項目として｢ユーモアのない/ユーモアのある｣の項目をあげた｡ 3. 老人像は全体として｢暇な｣,｢弱い｣,｢孤独な｣という否定的な老人イメージと｢経験に富む｣,｢暖かい｣という肯定的イメージで捉えられており,このイメージは実習前後で共通していた｡実習前後では全体として老人像に大きな変化はなかったものの,実習によって,より活動的な老人イメージを抱き,より現実的に老人をとらえていることが明らかになり,A園での老人看護学実習は教育上意義のある実習であると評価した｡ en-copyright= kn-copyright= en-aut-name=WatanabeKumi en-aut-sei=Watanabe en-aut-mei=Kumi kn-aut-name=渡辺久美 kn-aut-sei=渡辺 kn-aut-mei=久美 aut-affil-num=1 ORCID= en-aut-name=KondoMasuko en-aut-sei=Kondo en-aut-mei=Masuko kn-aut-name=近藤益子 kn-aut-sei=近藤 kn-aut-mei=益子 aut-affil-num=2 ORCID= en-aut-name=OhtaNiwa en-aut-sei=Ohta en-aut-mei=Niwa kn-aut-name=太田にわ kn-aut-sei=太田 kn-aut-mei=にわ aut-affil-num=3 ORCID= en-aut-name=IkedaToshiko en-aut-sei=Ikeda en-aut-mei=Toshiko kn-aut-name=池田敏子 kn-aut-sei=池田 kn-aut-mei=敏子 aut-affil-num=4 ORCID= en-aut-name=MaedaMakiko en-aut-sei=Maeda en-aut-mei=Makiko kn-aut-name=前田真紀子 kn-aut-sei=前田 kn-aut-mei=真紀子 aut-affil-num=5 ORCID= en-aut-name=OhtaTakeo en-aut-sei=Ohta en-aut-mei=Takeo kn-aut-name=太田武夫 kn-aut-sei=太田 kn-aut-mei=武夫 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=4 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=5 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=6 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 en-keyword=老人 (elderly) kn-keyword=老人 (elderly) en-keyword=イメージ (images) kn-keyword=イメージ (images) en-keyword=看護学生 (nursing students) kn-keyword=看護学生 (nursing students) en-keyword=看護実習 (nursing practice) kn-keyword=看護実習 (nursing practice) en-keyword=看護教育 (nursing education) kn-keyword=看護教育 (nursing education) END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=1 article-no= start-page=33 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The relation of Ikigai (the meaning of one's life) to one's behavioral pattern and belief, researched through the elderly persons at their discharge from hospital kn-title=老人の退院時における生きがいと生活行動および生活信条との関連 en-subtitle= kn-subtitle= en-abstract=There have been few researches about Ikigai of the elderly at the time of leaving the hospital and about the ways of their home nursing care. The purpose of this study is to clarify the relation of Ikigai to one's behavioral pattern and belief. In three national university hospitals and a general hospital in Chugoku region and Shikoku region, ninety-two patients above the age of 70, ready to discharge, were interviewed and given a questionnaire. The questions were about their body condition, behavioral pattern, and belief, and their Ikigai. More than eighty percent of them seem to lead a life worth living at the time of leaving the hospital. The behavioral pattern scores on the "working as a volunteer" and "growing plants" are on a high level of Ikigai. The belief scores on the "enjoy every day" is also on a high level of Ikigai. In this paper the result of this interview is reported and a better nursing care for them is discussed. kn-abstract=退院を控えた老人が,どの程度生きがいを持って退院していくのか,老人自身のどのような生き方が生きがいに影響しているのかについて知るため,それまでの健康状態や,生活信条,生活行動について,退院許可の出た70歳以上の患者92名を対象として,独自の調査用紙に基づき面接調査を行った｡生きが いとこれまでの健康度,生活信条,生活行動の関連性を,分散分析及びt検定により解析した｡生きがいの平均得点が高かった生活行動は｢ボランティア｣で,続いて｢植物｣であった。生きがいの平均得点が高かった生活信条は｢その日を楽しく生きる｣と回答した人が,回答しなかった人との間に有意差があり,老人の退院時の生きがいの得点が高い傾向を示すことが明らかとなった｡ en-copyright= kn-copyright= en-aut-name=WatanabeKumi en-aut-sei=Watanabe en-aut-mei=Kumi kn-aut-name=渡辺久美 kn-aut-sei=渡辺 kn-aut-mei=久美 aut-affil-num=1 ORCID= en-aut-name=NakanishiYoshiko en-aut-sei=Nakanishi en-aut-mei=Yoshiko kn-aut-name=中西代志子 kn-aut-sei=中西 kn-aut-mei=代志子 aut-affil-num=2 ORCID= en-aut-name=IkedaToshiko en-aut-sei=Ikeda en-aut-mei=Toshiko kn-aut-name=池田敏子 kn-aut-sei=池田 kn-aut-mei=敏子 aut-affil-num=3 ORCID= en-aut-name=TakataSetuko en-aut-sei=Takata en-aut-mei=Setuko kn-aut-name=高田節子 kn-aut-sei=高田 kn-aut-mei=節子 aut-affil-num=4 ORCID= en-aut-name=KondoMasuko en-aut-sei=Kondo en-aut-mei=Masuko kn-aut-name=近藤益子 kn-aut-sei=近藤 kn-aut-mei=益子 aut-affil-num=5 ORCID= en-aut-name=OhtaNiwa en-aut-sei=Ohta en-aut-mei=Niwa kn-aut-name=太田にわ kn-aut-sei=太田 kn-aut-mei=にわ aut-affil-num=6 ORCID= en-aut-name=InoshitaHikari en-aut-sei=Inoshita en-aut-mei=Hikari kn-aut-name=猪下光 kn-aut-sei=猪下 kn-aut-mei=光 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=4 en-affil= kn-affil=広島県立保健福祉短期大学 affil-num=5 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=6 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=7 en-affil= kn-affil=香川医科大学医学部看護学科 en-keyword=老人 (the elderly) kn-keyword=老人 (the elderly) en-keyword=生きがい (Ikigai) kn-keyword=生きがい (Ikigai) en-keyword=生活信条 (belief) kn-keyword=生活信条 (belief) en-keyword=生活行動 (behavioral pattern) kn-keyword=生活行動 (behavioral pattern) END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=1 article-no= start-page=23 end-page=31 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Present status of home health nursing in a Japanese hospital-based home health care agency kn-title=在宅看護における訪問看護内容の検討 ―病院を基盤とする訪問看護ステーションの事例調査― en-subtitle= kn-subtitle= en-abstract=We investigated the present status of home health nursing in a Japanese hospital-based home health care agency, to clarify present problems in home health nursing and to assess the roles of home health nurses. Based on our results, ADL of care recipients who lived alone were clearly independent compared with care recipients who lived with family care-givers. The level of ADL of both care recipients who lived with their spouses and those who lived with more than 2 family members were not different. It indicates that aged family care-givers assume great responsibility. In cases of bedridden recipients,daily life care was performed at a high rate, but mental care or teaching care was performed at a low rate. Home health nurses should focus on primary preventive care, mental care for recipients and care-givers, and teaching care or management of a care plan. kn-abstract=病院を基盤とした在宅看護提供機関における在宅看護の現状を調査し,在宅看護の現在の問題点を明らかにするとともに,在宅看護に携わる看護婦の役割について検討した｡本調査の結果,一人暮らしの患者は,家族に介護者のいる患者に比べ明らかにADLが高い場合も訪問看護を受けていることが分かった｡また,高齢者夫婦二人暮らしの患者と2世代以上家族の患者のADLに差はなく,このことは,高齢の介護者に相当の負担がかかっていると言える｡訪問看護内容としては, 日常生活自立度の低い患者への日常生活援助の実施率は高く,精神的支援や指導的看護技術の実施率は低かった｡在宅看護に携わる看護婦は, 日常生活援助に追われがちであるが,一次予防に焦点を当てたケア,患者や介護者の精神的支援,指導,ケアマネジメントを行うことは緊急の課題である｡ en-copyright= kn-copyright= en-aut-name=SatoYoshie en-aut-sei=Sato en-aut-mei=Yoshie kn-aut-name=佐藤美恵 kn-aut-sei=佐藤 kn-aut-mei=美恵 aut-affil-num=1 ORCID= en-aut-name=TakahashiKayo en-aut-sei=Takahashi en-aut-mei=Kayo kn-aut-name=高橋香代 kn-aut-sei=高橋 kn-aut-mei=香代 aut-affil-num=2 ORCID= en-aut-name=IkedaToshiko en-aut-sei=Ikeda en-aut-mei=Toshiko kn-aut-name=池田敏子 kn-aut-sei=池田 kn-aut-mei=敏子 aut-affil-num=3 ORCID= en-aut-name=MatsuedaMutsumi en-aut-sei=Matsueda en-aut-mei=Mutsumi kn-aut-name=松枝睦美 kn-aut-sei=松枝 kn-aut-mei=睦美 aut-affil-num=4 ORCID= en-aut-name=YanagawaKanou en-aut-sei=Yanagawa en-aut-mei=Kanou kn-aut-name=柳川協 kn-aut-sei=柳川 kn-aut-mei=協 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=2 en-affil= kn-affil=岡山大学教育学部 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=4 en-affil= kn-affil=岡山大学大学院教育学研究科 affil-num=5 en-affil= kn-affil=岡山大学教育学部 en-keyword=訪問看護 (home health nursing) kn-keyword=訪問看護 (home health nursing) en-keyword=看護内容 (nursing care) kn-keyword=看護内容 (nursing care) en-keyword=看護婦 (nurse) kn-keyword=看護婦 (nurse) END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=2 article-no= start-page=147 end-page=155 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of adult nursing practices using self-assessment form - analysis in 3rd and 5th weeks of practice - kn-title=学生の自己評価による成人看護実習の達成度 ―3週後･5週後の自己評価結果の分析― en-subtitle= kn-subtitle= en-abstract=The purpose of this study was to evaluate the adult nursing practices using a self-assessment form. Seventy-four third-grade nursing students assessed 11 items in the 3rd and 5th weeks of practice. The scores of all assessment items in the 5th week were significantly higher than these in the 3rd week. The lowest scoreing item at both 3rd and 5th weeks was understanding of the utility of social resources. The students assigned patients with malignant diseases reported higher scores on 3 assessment items. These findings suggest that students should share their experiences and learn about social resources during clinical practice. kn-abstract=この研究目的は,実習目標の達成度に対する学生の自己評価を明らかにすることである｡調査対象は短大の看護学科3年生74名である｡調査は自記式の調査票により成人看護実習の3週後と終了時の5週後に行った｡この自己評価は実習目標11項目について5件法で行った｡その結果,患者理解,患者指導,自己の内面の気づきなど目標は,3週後より5週間の実習によってより評価が高くなった｡最も自己評価が低いのは社会資源の活用の理解であった｡悪性の患者を受け持った学生の方は良性の患者の受け持ち学生より,人間としての態度や死生観などに関して5週後有意に高値であった｡今後の課題は,限られた実習期間内で,学生個々の経験をどのように共有させるかや患者の福祉について理解を深めることである｡ en-copyright= kn-copyright= en-aut-name=OhtaNiwa en-aut-sei=Ohta en-aut-mei=Niwa kn-aut-name=太田にわ kn-aut-sei=太田 kn-aut-mei=にわ aut-affil-num=1 ORCID= en-aut-name=IkedaToshiko en-aut-sei=Ikeda en-aut-mei=Toshiko kn-aut-name=池田敏子 kn-aut-sei=池田 kn-aut-mei=敏子 aut-affil-num=2 ORCID= en-aut-name=OhiNobuko en-aut-sei=Ohi en-aut-mei=Nobuko kn-aut-name=大井伸子 kn-aut-sei=大井 kn-aut-mei=伸子 aut-affil-num=3 ORCID= en-aut-name=KageyamaJingo en-aut-sei=Kageyama en-aut-mei=Jingo kn-aut-name=景山甚郷 kn-aut-sei=景山 kn-aut-mei=甚郷 aut-affil-num=4 ORCID= en-aut-name=KanaoNaomi en-aut-sei=Kanao en-aut-mei=Naomi kn-aut-name=金尾直美 kn-aut-sei=金尾 kn-aut-mei=直美 aut-affil-num=5 ORCID= en-aut-name=KobayashiYu en-aut-sei=Kobayashi en-aut-mei=Yu kn-aut-name=小林有 kn-aut-sei=小林 kn-aut-mei=有 aut-affil-num=6 ORCID= en-aut-name=HayashiYuko en-aut-sei=Hayashi en-aut-mei=Yuko kn-aut-name=林優子 kn-aut-sei=林 kn-aut-mei=優子 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=4 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=5 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=6 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=7 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 en-keyword=実習目標 (goal in practice) kn-keyword=実習目標 (goal in practice) en-keyword=自己評価 (self-assessment) kn-keyword=自己評価 (self-assessment) en-keyword=成人看護実習 (adult nursing practice) kn-keyword=成人看護実習 (adult nursing practice) en-keyword=看護学生 (nursing student) kn-keyword=看護学生 (nursing student) en-keyword=実習期間 (period of practice) kn-keyword=実習期間 (period of practice) END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=2 article-no= start-page=65 end-page=74 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990226 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Development of an aptitude scale for nursing students kn-title=看護学生の適性に関する尺度開発の試み ―信頼性･妥当性の検証― en-subtitle= kn-subtitle= en-abstract=Efforts to ensure the necessary aptitude for health care professionals as well as knowledge and skills taught to nursing students are important to provide proper health services and care. A questionnaire containing 22 items was developed to evaluate teaching effectiveness. These items were obtained from previous studies and our findings in nursing practice and teaching. Stability reliability of this method was estimated using test/retest. The correlation coefficient for individual items ranged from 0.36 to 0.71. Only 2 of the 22 items showed correlation values below 0.40. Internal reliability of the 5 subscales was determined using the Cronbach's alpha coefficient 0.83. The values ranged from 0.56 to 0.80. Five components extracted by factor analysis were identified as follows : and . kn-abstract=看護教育では,看護者として必要な知識,技術のみならず看護するのにふさわしい態度や姿勢等を育成することを重視している｡このような看護者にふさわしい態度形成を援助する教育の成果を評価するために看護学生の適性に関する尺度開発を試みた｡尺度に用いる項目は,看護者にふさわしい態度や性格特性及び適性等に関する過去の文献調査と筆者等の臨床看護及び看護教育の経験とで検討し決定した｡最終的に絞り込んだ項目は,22項目であった｡この項目の信頼性･妥当性を検証するために,医療技術短大の看護学生206人を対象に質問紙調査を実施した｡信頼性については,76人を対象に再検査を実施し安定性を検討した｡その結果,相関係数の一番低い項目は｢研究心｣｢自制心｣で,0.36であった｡残りの項目は,相関係数0.40以上で,一番高い項目は｢冷静｣の0.71であった｡内的整合性を示すCronbach's α信頼性係数は,全項目では0.83であった｡因子分析の結果得られた5因子に基づく下位尺度のCronbach's α信頼性係数は,最も高いものは<リーダーシップ>0.80であり,最も低いものは<精神的成熟>0.56であった｡構成概念の妥当性を検討するために因子分析をおこなった結果,5因子が抽出された｡それぞれを<リ ーダーシップ><社会性><探求心><精神的成熟><忍耐>と命名し,下位尺度とした｡ en-copyright= kn-copyright= en-aut-name=IkedaToshiko en-aut-sei=Ikeda en-aut-mei=Toshiko kn-aut-name=池田敏子 kn-aut-sei=池田 kn-aut-mei=敏子 aut-affil-num=1 ORCID= en-aut-name=KondohIsao en-aut-sei=Kondoh en-aut-mei=Isao kn-aut-name=近藤勲 kn-aut-sei=近藤 kn-aut-mei=勲 aut-affil-num=2 ORCID= en-aut-name=TanakaKoji en-aut-sei=Tanaka en-aut-mei=Koji kn-aut-name=田中宏二 kn-aut-sei=田中 kn-aut-mei=宏二 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 affil-num=2 en-affil= kn-affil=岡山大学教育学部 affil-num=3 en-affil= kn-affil=岡山大学教育学部 en-keyword=看護学生 (nursing students) kn-keyword=看護学生 (nursing students) en-keyword=看護教育 (nursing education) kn-keyword=看護教育 (nursing education) en-keyword=看護 (nursing) kn-keyword=看護 (nursing) en-keyword=適性 (aptitude) kn-keyword=適性 (aptitude) en-keyword=尺度 (scale) kn-keyword=尺度 (scale) END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue=1 article-no= start-page=15 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20011225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Detection of metacercariae of Spelotrema capellae in crabs from Sanyo District, Japan kn-title=山陽地方のカニにおける吸虫Spelotrema capellaeのメタセルカリアの感染状況 en-subtitle= kn-subtitle= en-abstract=The detection of metacercariae of Spelotrema capellae was investigated in crabs that inhabited the river mouth in the Sanyo District, Japan. The metacercaria was detected in crabs from 4 areas of the Hiroshima Prefecture and from 1 area of the Okayama Prefecture. From 2 areas in the Hiroshima Prefecture, the crab, Hemigrapsus penicillatus, showed the high prevalence of metacercariae. This crab could be a source of infection by Spelotrema capellae in domestic cats in these areas. kn-abstract=吸虫Spelotrema capellaeの飼い猫への感染源を調べるために,広島県福山市を中心とした瀬戸内沿岸の河口域に生息するカニにおけるメタセルカリアの感染状況を調査した｡調査地のうち広島児内の4ヵ所と岡山県内の1ヵ所のケフサイソガニHemigrapsus PenicillatusからS. capellaeのメタセルカリアが検出された｡特に,過去に症例報告のあった猫の行動圏内にある福山市の2ヵ所のケフサイソガニからは高率に検出された｡したがってこれらの地方においては飼い猫へのS. capellaeの感染源は河口産のケフサイソガニであることが強く示唆された｡ en-copyright= kn-copyright= en-aut-name=SaitoTetsuro en-aut-sei=Saito en-aut-mei=Tetsuro kn-aut-name=斎藤哲郎 kn-aut-sei=斎藤 kn-aut-mei=哲郎 aut-affil-num=1 ORCID= en-aut-name=KuyaMitsuo en-aut-sei=Kuya en-aut-mei=Mitsuo kn-aut-name=久家光雄 kn-aut-sei=久家 kn-aut-mei=光雄 aut-affil-num=2 ORCID= en-aut-name=HashiguchiMasahiro en-aut-sei=Hashiguchi en-aut-mei=Masahiro kn-aut-name=橋口正大 kn-aut-sei=橋口 kn-aut-mei=正大 aut-affil-num=3 ORCID= en-aut-name=IkedaFumio en-aut-sei=Ikeda en-aut-mei=Fumio kn-aut-name=池田文雄 kn-aut-sei=池田 kn-aut-mei=文雄 aut-affil-num=4 ORCID= en-aut-name=YamaguchiHiroyuki en-aut-sei=Yamaguchi en-aut-mei=Hiroyuki kn-aut-name=山口裕之 kn-aut-sei=山口 kn-aut-mei=裕之 aut-affil-num=5 ORCID= en-aut-name=YoshidaKunie en-aut-sei=Yoshida en-aut-mei=Kunie kn-aut-name=吉田邦恵 kn-aut-sei=吉田 kn-aut-mei=邦恵 aut-affil-num=6 ORCID= en-aut-name=TonguYasumasa en-aut-sei=Tongu en-aut-mei=Yasumasa kn-aut-name=頓宮廉正 kn-aut-sei=頓宮 kn-aut-mei=廉正 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=斎藤獣医科病院 affil-num=2 en-affil= kn-affil=広島県立教育センター affil-num=3 en-affil= kn-affil=福山市市民病院 affil-num=4 en-affil= kn-affil=池田獣医科 affil-num=5 en-affil= kn-affil=山口動物病院 affil-num=6 en-affil= kn-affil=吉田動物クリニック affil-num=7 en-affil= kn-affil=岡山大学法学部 en-keyword=Spelotrema capellae kn-keyword=Spelotrema capellae en-keyword=ケフサイソガニ (crab) kn-keyword=ケフサイソガニ (crab) en-keyword=Hemigrapsus penicillatus kn-keyword=Hemigrapsus penicillatus en-keyword=メタセルカリア (metacercaria) kn-keyword=メタセルカリア (metacercaria) en-keyword=山陽地方 (Sanyo District) kn-keyword=山陽地方 (Sanyo District) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=1 article-no= start-page=57 end-page=66 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20051225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Age dependent changes of menstrual pain of the women kn-title=リプロダクティブステージからみた月経痛の実態 en-subtitle= kn-subtitle= en-abstract=PURPOSE: Menstruation and menstrual pain of the women at various reproductive stages were investigated. METHOD: Changes in menstruation and menstrual pain of women at various reproductive stages were investigated by self-reporting questionnaires. Subjects were 193 healthy women of 18~52 years old with regular menstrual cycles. According to their age the subjects were classified into four groups; teens, 20~24 years old, 25~34 years old, and older than 35 years old. RESULTS: The average age of total subjects was 26.3±8.8, and 27.5% of the women have had gave birth. As the age advances, menstrual pain tends to be reduced and the uses of pain-killer as well as disturbances of daily life during menstruation were decreased. Also, menstrual cycles become more regular and the amount of menstrual bleeding and blood clots were decreased. Taken together, our findings suggest that age of the patients, in addition to sexual maturation and psychosocial aspects, should be taken into account for the appropriate care of women with dysmenorrhea. kn-abstract=18～52歳の月経周期のある健康な女性193名を10代,20～24歳,25～34歳,35歳以上の4つのリプロダクティブステージに分類し,月経及び月経痛に関する実態調査を実施した｡結果①規則的な月経周期の割合は,リプロダクティブステージが進むにつれ増加し,経血量は減少傾向を示した｡②月経痛はリプロダクティブステージの進行と共に軽減し,鎮痛剤使用頻度,日常生活への影響が少なくなる傾向を認めた｡③各リブログクティブステージの特徴は,10代では月経痛の頻度や日常労作への影響が最も多く,血塊の出現率が最も高率であった｡20～24歳は10代と類似していたが,鎮痛剤使用頻度は最も高率であった｡25～34歳では最も安定した性成熟状態を示し,月経痛は｢時々あり｣が最も高率であったが,血塊の出現率が高かった｡35歳以上では月経痛のない人が最も高率であり,生活への支障が最も少なかったが,｢1日3回以上｣の鎮痛剤使用は他のリプロダクティブステージと変わらなかった｡以上の結果に加えてリプロダクティブステージにおける月経周期や経血量の特徴を考えあわせると,身体的な性成熟機能と心理社会的側面を考慮し,各リプ ロダクティブステージに適した月経痛への対応が必要であると考える｡ en-copyright= kn-copyright= en-aut-name=IkedaTomoko en-aut-sei=Ikeda en-aut-mei=Tomoko kn-aut-name=池田智子 kn-aut-sei=池田 kn-aut-mei=智子 aut-affil-num=1 ORCID= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=2 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 en-keyword=月経 (Menstruation) kn-keyword=月経 (Menstruation) en-keyword=月経痛 (Menstrual pain) kn-keyword=月経痛 (Menstrual pain) en-keyword=リプロダクティブステージ (Reproductive stage) kn-keyword=リプロダクティブステージ (Reproductive stage) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=72 end-page=77 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy and quality of life in patients with bronchial asthma kn-title=温泉療法と気管支喘息患者のQOL en-subtitle= kn-subtitle= en-abstract=Bronchial asthma is in qeneral a disease with good prognosis and can be controlled with usual antiasthmatic drugs. However, there are some patients whose asthma attacks can be controlled only with use of qlucocorticoids. In these patients, adverse side effects of many kinds of drugs containing bronchodilators and qlucocorticoids, and exercise-induced asthma attacks are often observed. Thus, the patients have to keep limitation of exercise during treatment of their asthma attacks, leading to decrease psychical activity. Complex spa therapy for bronchial asthma consists of swimming training in a hot spring pool (exercise), inhalation of iodine salt solution and fango therapy. Spa therapy has two kinds of actions : direct action to airways and indirect action to other organs except airways. The direct action of spa therapy improves subjective and objective symptoms, and ventilatory function, and suppress bronchial hyperresponsiveness. In contrast, improvemment of suppressed function of adrenocortical glands, of mental activity, and of autonomic nerve system is observed as indirect action of spa therapy. These actions play an important role for improvement of QOL of patients with bronchial asthma. kn-abstract=気管支喘息のなかでも,ステロイド依存性重症難治性喘息では,気管支拡張薬その他の抗喘息薬のみでは発作のコントロ-ルが極めて困難であり,したがって副腎皮質ホルモンの長期投与を余儀なくされる｡そして,投与薬剤,特に気管支拡張薬の心臓刺激作用や副腎皮質ホルモンの副作用,さらには運動誘発喘息がひき起こされやすいなどの理由により,体動制限が加えられることが多い｡このことが,また精神活動の低下へとつながる｡したがって,重症難治性喘息患者のQuality of life (QOL)を高めるためには,薬剤の副作用をできるだけ低くするための投与薬剤の減量をはかるとともに,十分な運動のもとに治療を行い全身状態の改善,それにともなう精神活動の活性化をはかる必要がある｡かかる観点からすれば,温泉療法は最も理想的な治療法であり,その直接作用(気道への作用:気道浄化作用,気道粘膜正常化作用)により,白,他覚症状の改善,換気機能の改善,気道過敏性の低下などが観察される｡また,間接作用(気道以外への作用)により,全身状態の改善,自律神経系の安定化作用,副腎皮質機能の改善作用などが見られる｡すなわち,重症難治性喘息に対する温泉療法では,十分な運動のもとに,精神活動の活性化をともなった喘息症状の改善がはかられるため,患者のQOLをより一層高めることができると判断される｡ en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保﨑泰弘 kn-aut-sei=保﨑 kn-aut-mei=泰弘 aut-affil-num=5 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=6 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name=池田敏 kn-aut-sei=池田 kn-aut-mei=敏 aut-affil-num=9 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部公衆衛生学 affil-num=10 en-affil= kn-affil=岡山大学医学部公衆衛生学 en-keyword=温泉療法 (spa therapy) kn-keyword=温泉療法 (spa therapy) en-keyword=重症難治性喘息 (lntractable asthma) kn-keyword=重症難治性喘息 (lntractable asthma) en-keyword=運動 (exercise) kn-keyword=運動 (exercise) en-keyword=精神活動 (phychical activity) kn-keyword=精神活動 (phychical activity) en-keyword=QOL kn-keyword=QOL END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=30 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息患者の血清コーチゾール値について. 副腎皮質ホルモン投与および年齢との関連 kn-title=Serum cortisol levels in patients with bronchial asthma. Relationship to glucocorticoid therapy and patient age. en-subtitle= kn-subtitle= en-abstract=気管支喘息94例を対象に,副腎皮質ホルモン投与および年齢との関連のもとに,血清コーチゾール値の変動を観察した｡まず副腎皮質ホルモンの投与量および投与期間により以下の3群に分けて検討した｡グループA :副腎皮質ホルモン,プレドニソロンに換算して1日5mg以上を2年間以上にわたり使用している症例,グループB:プレドニソロン1日5mg以下で2年間以内の使用症例, グループC:副腎皮質ホルモンを全く使用していない症例｡その結果,グループAの血清コーチゾ-ル値(2.4±1.2mcg/㎗)は,グループB (6.8±3.7mcg/㎗)(p 0.01)やC(12.6±3.9mcg/㎗)(p 0.001)に比べ有意に低い値であった｡2､グループCでは,70才以上の症例の血清コーチゾ-ル値は,0-39才の症例(p 0.0l),40-49才の症例(p 0.05),そして,50-59才の症例(p 0.02)に比べ有意に低い値であった｡これらの結果は,血清コーチゾール値は,副腎 皮質ホルモンの投与量や投与期間以外にも､加齢による影響を受ける可能性を示唆している｡ kn-abstract=Serum cortisol levels were examined in 94 patients with bronchial asthma in relation to dose of glucocorticoids and age. 1. The level of serum cortisol was significantly lower in group A patients, treated with glucocorticoids (prednisolone of 5mg/day or more) for more than 2 years, (2.4±1.2mcg/㎗) than in group B, treated with glucocorticoids (prednisolone of 5mg or less) for less than 2 years, (6.8±3.7mcg/㎗) (p<0.001) and in group C, treated without glucocorticoids, (12.6±3.9mcg/㎗) (p<0.001). The serum cortisol level was also significantly lower in group B than in group C (p<0.001). 2. The level of serum cortisol was significantly lower in patients over the age of 70 compared to that in those aged between 0 and 39 years (p<0.01) and those between 40 and 49 (p<0.05), and those between 50 and 59 (p<0.02). The level was also lower in patients between 60 and 69 compared to that in those between 0 and 39, however, this was not significant. These results demonstrate that the level of serum cortisol decreases by long-term glucocorticoid regimen and with aging. en-copyright= kn-copyright= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保﨑泰弘 kn-aut-sei=保﨑 kn-aut-mei=泰弘 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name=池田敏 kn-aut-sei=池田 kn-aut-mei=敏 aut-affil-num=9 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部公衆衛生学 affil-num=10 en-affil= kn-affil=岡山大学医学部公衆衛生学 en-keyword=serum cortisol level (血清コーチゾール) kn-keyword=serum cortisol level (血清コーチゾール) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) en-keyword=clinical asthma type (臨床病型) kn-keyword=clinical asthma type (臨床病型) en-keyword=glucocorticoids (副腎皮質ホルモン) kn-keyword=glucocorticoids (副腎皮質ホルモン) en-keyword=aging (加齢) kn-keyword=aging (加齢) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=21 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=老年者気管支喘息の各臨床病型における換気機能の特徴 kn-title=Characteristics of ventilatory function in clinical types of bronchial asthma in the elderly en-subtitle= kn-subtitle= en-abstract=気管支喘息55例(老年症例-65才以上-25例,若年症例-59才以下-30例)における換気機能の特徴について,各臨床病型別に検討を加えた｡1.まず対象症例の臨床病型の病態的特徴を,気管支肺胞洗浄(BAL)液中の細胞成分で検討 すると,Ⅱの細気管支閉塞型の症例では,好中球の増加が,またIa-2やIbの過分泌型の症例では好酸球の増加が特徴的であった｡2.% FVC,FEVL(1.0%),% PEFRなどの換気パラメーターは,Ⅱ型において他の病型に比べ低値を示す傾向は見られたが,各病型間に有意差は見られなかった｡3.% MMF,% V(50),% V(25)などのどちらかと言えば小ないし細気管支領域の換気障害を示す換気パラメーターの値は,老年および若年症例ともⅡ型(細気管支閉塞型)において最も低い値が示された｡そして,若年症例では,Ⅱ型の症例においてこれからの換気パラメーターの値は,Ia-1型(単純性気管支攣縮型)に比べ有意に低い値を示した｡しかし,老年症例ではⅡ型におけるこれらの換気パラメータ-の値は,他の臨床病型との問に有意の差は見られなかった｡ kn-abstract=Ventilatory function was examined in 55 patients with asthma (25 older patients over the age of 60 and 30 younger patients under the age of 59) in relation to four clinical types classified by clinical symptoms and signs. 1. Regarding cellular composition of bronchoalveolar lavage (BAL) fluid, number of BAL neutrophils was significantly increased in type II, bronchiolar obstruction type, of older and younger patients compared to that in type la-1 and type la-2 of same patients. In contrast, BAL eosinophilia was observed in type la-2 of both older and younger patients and in type Ib of younger patients. 2. The values of % FVC, FEV(1.0%) and % PEFR were not significantly different among four clinical types of asthma and between older and younger patients, although the values of these ventilatory parameters in type II asthma showed a tendency to be lower compared to other clinical types. 3. The values of % MMF, % V(50), and % V(25), showing ventilatory dysfunction of small airways, were lowest in type II asthma of both older and younger patients among four clinical types. A significant difference in these ventilatory parameters of type II asthma compared to type la-1 asthma was observed in younger patients, but not in older patients. These results show that ventilatory dysfunction of small airways is related to clinical asthma types in younger patients, and to aging rather than asthma types in older patients. en-copyright= kn-copyright= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保﨑泰弘 kn-aut-sei=保﨑 kn-aut-mei=泰弘 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name=池田敏 kn-aut-sei=池田 kn-aut-mei=敏 aut-affil-num=9 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部公衆衛生学 affil-num=10 en-affil= kn-affil=岡山大学医学部公衆衛生学 en-keyword=Ventilatory function (換気機能) kn-keyword=Ventilatory function (換気機能) en-keyword=Clinical asthma type (臨床病型) kn-keyword=Clinical asthma type (臨床病型) en-keyword=BAL cells (BAL細胞) kn-keyword=BAL cells (BAL細胞) en-keyword=aging (加齢) kn-keyword=aging (加齢) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=1 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ダニ喘息における気道遊走細胞からのヒスタミン遊離の加齢による減少 kn-title=Decrease in histamine release from bronchoalveolarcells with aging in patients with atopic asthma sensitive to house dust mite en-subtitle= kn-subtitle= en-abstract=ダニ喘息14例を対象に,ハウスダストエキスによる気道遊走細胞からのヒスタミン遊離と加齢との関連について検討を加えた｡1.気管支肺胞洗浄液(BALF)中の総細胞数は,20-39才の症例群(6.25×10(6)) に比べ,40才以 上の症例群(9.1×10(6)) でやや多い傾向が見られたが,推計学的には有意差は見られなかった｡2.BALF中好酸球数は,20-39才と40才以上の症例群間に差は見られなかった｡3.BALF中好塩基性細胞数は,40才以上の症例群(0.39±0.24×10(2)/mℓ)に比べ,20-39才の症例群(1.85±1.03×10(2)/mℓ)において有意に多い傾向が見られた(P<0.001)｡4.ハウスダストエキスによるBALF中細胞からのヒスタミン遊離は,40才以上の症例群(0%) に比べ20-39才の症例群(38.1±24.8%)において有意に高い結果が得られた(P<0.001)。これらの結果より,ダニ喘息(アトピー型喘息)における気道遊走細胞からのヒスタミン遊離は,加齢とともに減少することが示唆された｡ kn-abstract=Histamine release from bronchoalveolar cells induced by house dust mite (HDm) was compared in patients with atopic asthma sensitive to HDm in relation to age. 1. Total cell number in bronchoalveolar lavage (BAL) fluid was larger in patients over the age of 40 years (9.10×10(6)) than in those aged between 20 and 39 years (6.25×10(6)), however, this was not significant. 2. Number of BAL eosinophils was not significantly different between the two age groups. 3. Number of BAL basophilic cells was significantly higher in younger patients (20-39 years) (1.85±1.03×10(2)/mℓ) than in older patients (40+ years) (0.39±0.24×10(2)/mℓ) (p<0.001). 4. Histamine release from BAL cells induced by HDm was significantly higher in younger patients (38.1±24.8%) than in older patients (0%) (p<0.001). These results suggest that histamine release from BAL cells in patients with HDm allergy decreases with aging. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保﨑泰弘 kn-aut-sei=保﨑 kn-aut-mei=泰弘 aut-affil-num=5 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=6 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name=池田敏 kn-aut-sei=池田 kn-aut-mei=敏 aut-affil-num=9 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部公衆衛生学 affil-num=10 en-affil= kn-affil=岡山大学医学部公衆衛生学 en-keyword=Bronchial asthma kn-keyword=Bronchial asthma en-keyword=House dust allergy kn-keyword=House dust allergy en-keyword=Histamine release kn-keyword=Histamine release en-keyword=Bronchoalveolar cells kn-keyword=Bronchoalveolar cells END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=1 article-no= start-page=63 end-page=72 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On Measures of Improving Teaching Skills toward the Goal of Linking Acquisition and Exploration through Application. kn-title=習得と探求を活用でつなぐ算数授業改善の方策 en-subtitle= kn-subtitle= en-abstract=The teaching guideline has been revised in 2008 from the current emphasis on the power of living under relaxed school curriculum toward a new goal of which 'acquisition,' 'application,' 'exploration' are some of the key words symbolic of the overall redirection. In line with the new policy teaching skills in mathematics education have been under consideration to fulfill the purpose of improved acquisition and exploration by cultivating the power of application. Under the current relaxed curriculum instruction content has been reduced by 30 percent, and teaching hours 14 percent. This has occasioned a widespread criticism of lowered performance on the part of students. The scholastic aptitude test conducted in 2007 and 2008 on national scale has revealed their weakness in the ability of applying what they have learned. Thus the improvement of application power has emerged as an urgent problem to be tackled. In consequence the present paper tries to make clear the relative position of application ability in the scheme of acquisition, application, and exploration; on the basis of this we move on to discuss what we can do toward improving learners' application power in mathematics class. kn-abstract=｢ゆとりの中で生きる力｣の育成を重視した学習指導要領が改訂され､｢習得｣｢活用｣｢探究｣を強調した新学習指導要領が2008年に告示された｡教育課程の国際的通用性が強調され､算数教育においても､習得と探究を活用でつなぐ授業改善が求められている｡ゆとり教育では､指導内容が30%､指導時数が14%縮減されたため､学力低下論議が過熱化してきている｡昨年度及び本年度とも実施された全国学力調査において､活用力には課題があると報告された｡このため､算数科においては活用力の育成が算数の授業改善の喫緊の課題としてクローズアップされている｡そこで､｢習得｣｢活用｣｢探究｣教育における｢活用｣の位置づけ明確にするとともに､算数科で活用力を育成するためにどんな授業改善をすべきか､その方策を検討する｡ en-copyright= kn-copyright= en-aut-name=KurosakiToyoo en-aut-sei=Kurosaki en-aut-mei=Toyoo kn-aut-name=黒﨑東洋郎 kn-aut-sei=黒﨑 kn-aut-mei=東洋郎 aut-affil-num=1 ORCID= en-aut-name=SatoManabu en-aut-sei=Sato en-aut-mei=Manabu kn-aut-name=佐藤学 kn-aut-sei=佐藤 kn-aut-mei=学 aut-affil-num=2 ORCID= en-aut-name=YamanoSadatoshi en-aut-sei=Yamano en-aut-mei=Sadatoshi kn-aut-name=山野定寿 kn-aut-sei=山野 kn-aut-mei=定寿 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=大阪教育大学附属池田小学校 affil-num=3 en-affil= kn-affil=岡山大学 en-keyword=習得 (Acquisition) kn-keyword=習得 (Acquisition) en-keyword=活用 (Application) kn-keyword=活用 (Application) en-keyword=探究 (Exploration) kn-keyword=探究 (Exploration) en-keyword=読解力 (Reading Literacy) kn-keyword=読解力 (Reading Literacy) en-keyword=言語活動の充実 (Solid of Language Activity) kn-keyword=言語活動の充実 (Solid of Language Activity) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=79 end-page=84 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ⅱ型喘息(細気管支閉塞型)と気管支肺胞洗浄液の好中球数 kn-title=Type Ⅱ (bronchiolar obstruction) asthma and number of neutrophils in bronchoalveolar lavage (BAL) fluid en-subtitle= kn-subtitle= en-abstract=気管支喘息は,その臨床症状より,Ia型(Ia-1およびIa-2),Ib型およびⅡ型の3つの病型に分けることができる(臨床分類)｡また,同時に臨床所見および検査により分類することができる(スコアー分類)｡いずれの分類においても,BAL液中の好中球の著増および高度な% V25値の低下がⅡ細気管支閉塞型の特徴的所見である｡しかしながら,BAL液中の好中球の増加をともなわないⅡ型喘息が存在することが明らかにされている｡これらの症例では,BAL液 中好中球増加をともなう症例に比べ平均年齢が高い｡しかし,FEVl.0% 値､BAL液中リンパ球頻度や血清IgG値などは､好中球増加をともなう症例ほどの低下傾向は見られない｡これらの結果はBAL液中好中球増加をともなうⅡ型z喘息の発症機序には､液性および細胞性免疫能の低下が､また､BAL液中好中球増加をともなわないⅡ型喘息では､加齢がある程度関連していることを示 している。 kn-abstract=Bronchial asthma is classified into three types ; type Ia (Ia-1 and Ia-2), type Ib, and type Ⅱ, by clinical symptoms (clinical diagnosis). Asthma is also classified by clinical findings and examinations (score diagnosis). Both classification systems show that markedly increased proportion of BAL neutrophils and marked decrease in % V25 value are characteristic of type Ⅱ, bronchiolar　obstruction, asthma. However, there are some type Ⅱ asthma patients without BAL neutrophilia. In these patients, age is higher compared to those with BAL enutrophlia. Decrease in FEV1.0% value and decrease in the proportion of BAL lympocytes and serum IgG level, are not so remarkable as decrease in those with BAL neutrophilia. It has been suggested that type Ⅱ asthma with BAL neutrophilia correlates with suppression of humoral and cellular immunity, and same type of astma without BAL neutrophilia is in part caused by aging. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=4 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=5 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=6 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=7 ORCID= en-aut-name=TakeuchiKazuaki en-aut-sei=Takeuchi en-aut-mei=Kazuaki kn-aut-name=竹内一昭 kn-aut-sei=竹内 kn-aut-mei=一昭 aut-affil-num=8 ORCID= en-aut-name=NawaYuichiro en-aut-sei=Nawa en-aut-mei=Yuichiro kn-aut-name=名和由一郎 kn-aut-sei=名和 kn-aut-mei=由一郎 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name=池田敏 kn-aut-sei=池田 kn-aut-mei=敏 aut-affil-num=12 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=12 en-affil= kn-affil=岡山大学医学部公衆衛生学 affil-num=13 en-affil= kn-affil=岡山大学医学部公衆衛生学 en-keyword=Asthma classification (喘息分類) kn-keyword=Asthma classification (喘息分類) en-keyword=BAL lymphocytes (BALリンパ球) kn-keyword=BAL lymphocytes (BALリンパ球) en-keyword=BAL neutrophils (BAL好中球) kn-keyword=BAL neutrophils (BAL好中球) en-keyword=% V25 value kn-keyword=% V25 value en-keyword=Ⅱ型喘息 kn-keyword=Ⅱ型喘息 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=63 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=サーモグラフィーによる体表面温度の測定 kn-title=Evaluation of Body Surface Temperature by Thermography en-subtitle= kn-subtitle= en-abstract=健常人並びに糖尿病患者を対象にして下肢の体表面温度を測定した｡測定にはサーモグラフィーを用い,得られた画像の数値化にはコンピュータを用いた画像処理システムを利用した｡健常人を用いた実験では,20℃の水を用いた冷水負荷を5分間行うことにより,冷水負荷後,下肢の体表面温度は時間とともに上昇して30分後に良好な回復を得ることができた｡画像処理により28℃以上の体表面温度を呈した下肢の面積を負荷前と比較したところ,回復率は,2名の健常人についてみるとそれぞれ83%,88%であった｡27℃で画像処理を行った場合には回復率は93%となり過大評価される可能性があった｡また,29℃で画像処理を行ったところに,逆に,64%となり過少評価される可能性があり,28℃が最も良い条件であった｡この様な条件下で,糖尿病患者7名について同様に測定を行ったところ,1名は健常人と同じく99%の良好な回復率を呈した｡しかし,他の1名は56%であり,残りの,5名は6%以下であった｡この様に,糖尿病患者では,下肢の体表面温度の冷水負荷後の回復率に顕著な差を認めた｡この差は,糖尿病患者における,末梢循環障害の程度を反映しているものと考えられた｡この様にコンピュータを用いた画像処理システムの応用によりサーモグラフィーの画像は数値化することが出来,測定結果はより客観的に据えることが可能となった｡画像処理されたサーモグラフィーは下肢の循環障害を持つ患者の末梢血流量の評価に有用な測定方法であると考えられた。 kn-abstract=Body Surface Temperature was observed by thermography. The surface temperature of a healthy person's lower limbs, after being cooled in a water bath, increased in parallel with time. Patients with Diabetes Mellitus had different patterns in the rate of increase of the surface temperature. After cold loading, one patient had a 99% recovery ratio of surface temperature, the same level as healthy volunteers (83%, and 88%), as calculated by a picture processing program with the computerized thermotracer. However, the recovery ratio of other patients was poorer, ranging from 56% to under 6% recovery. This measurement of elevation of body temperature is useful for the estimation of peripheral blood flow in patients with lower limbcirculation failure. en-copyright= kn-copyright= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=1 ORCID= en-aut-name=NawaYuichiro en-aut-sei=Nawa en-aut-mei=Yuichiro kn-aut-name=名和由一郎 kn-aut-sei=名和 kn-aut-mei=由一郎 aut-affil-num=2 ORCID= en-aut-name=TakeuchiKazuaki en-aut-sei=Takeuchi en-aut-mei=Kazuaki kn-aut-name=竹内一昭 kn-aut-sei=竹内 kn-aut-mei=一昭 aut-affil-num=3 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=4 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=5 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=6 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=7 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name=池田敏 kn-aut-sei=池田 kn-aut-mei=敏 aut-affil-num=12 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=12 en-affil= kn-affil=岡山大学医学部公衆衛生学 affil-num=13 en-affil= kn-affil=岡山大学医学部公衆衛生学 en-keyword=Thermography (サーモグラフィー) kn-keyword=Thermography (サーモグラフィー) en-keyword=Diabetes Mellitus (糖尿病) kn-keyword=Diabetes Mellitus (糖尿病) en-keyword=Peripheral Circulation (末梢循環) kn-keyword=Peripheral Circulation (末梢循環) en-keyword=Cold Loading (冷水負荷) kn-keyword=Cold Loading (冷水負荷) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=71 end-page=79 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Application of hot spring pool training in　outpatients with chronic diseases and its clinical evaluation kn-title=通院患者の温泉プール利用状況とその臨床的評価 en-subtitle= kn-subtitle= en-abstract=For three months from April to June in 1996, 2109(30.8%) of 6848 outpatients (the total number) had swimming and walking traning in a hot spring pool. Of the 213 patients (the actual number), the numbers of female patients (72.3%), of patients over the age of 50 (80.3%), and of those coming inside Tottori prefecture (88.3%) were larger in analysis by the consultation cards for rehabillitation. The results of questionnaire from the patients performed from December 1996 to January 1997 demonstrated that patients with chronic respiratory disease had pool training 1 to 2 times a week (50.0%) and for longer term (more than 3 years, 52.9%), and patients with chronic pain disease had the training 3 to 5 times a week (38.0%) and for shoter term (less than 3 years, 61.9%). It was suggested from the results that tha training in a hot spring pool improved subjective and objective symptoms of each disease, and, furthermore, brought about improvement of general condition, psychological relaxation, and a change of feeling. kn-abstract=1996年4月より6月までの3ヵ月間に,三朝分院内の温泉プールで水泳ないし歩行訓練を受けた内科外来患者は延べ2109例(実数213例)で,外来患者総数(延べ6848例)に対する利用率は30.8%であった｡これらの対象症例について,リハビリテーション受診カードにより,性別,年令別,疾患別の検討を行った｡その結果,性別では女性が多く(72.3%),年齢別では50才以上の患者が多い(80.3%)傾向が見られた｡また,地域別検討では,鳥取県内からの患 者が多い(88.3%)傾向であった。さらに,1996年12月より1997年1月へかけて,アンケート調査を行い(集計数;64例)継続期間,利用回数,効果を感じた期間,効果のあった症状などについて疾患別に比較検討した｡その結果,慢性閉塞性肺疾患を主とした呼吸器疾患では,週に1～2回の利用回数(50.0%)で長期間(3年以上:52.9%)続けている患者が多い傾向であった｡また慢性関節リウマチ,腰痛などの慢性疼痛性疾患では,訓練期間は比較的短期間であっ たが（3年以下:52.9%),利用回数は週に3～5回(38.0%)と多い傾向が見られた。温泉プール訓練では,疾患本来の症状改善に加えて,全身状態の改善,精神的リラックス,気分転換などを感じていることが示唆された｡ en-copyright= kn-copyright= en-aut-name=NishimuraNobuko en-aut-sei=Nishimura en-aut-mei=Nobuko kn-aut-name=西村伸子 kn-aut-sei=西村 kn-aut-mei=伸子 aut-affil-num=1 ORCID= en-aut-name=KasuiHayako en-aut-sei=Kasui en-aut-mei=Hayako kn-aut-name=賀須井捷子 kn-aut-sei=賀須井 kn-aut-mei=捷子 aut-affil-num=2 ORCID= en-aut-name=YoshioKeiko en-aut-sei=Yoshio en-aut-mei=Keiko kn-aut-name=吉尾慶子 kn-aut-sei=吉尾 kn-aut-mei=慶子 aut-affil-num=3 ORCID= en-aut-name=NakamuraAkemi en-aut-sei=Nakamura en-aut-mei=Akemi kn-aut-name=中村あけみ kn-aut-sei=中村 kn-aut-mei=あけみ aut-affil-num=4 ORCID= en-aut-name=IkedaAkiko en-aut-sei=Ikeda en-aut-mei=Akiko kn-aut-name=池田昭子 kn-aut-sei=池田 kn-aut-mei=昭子 aut-affil-num=5 ORCID= en-aut-name=FukuiYumi en-aut-sei=Fukui en-aut-mei=Yumi kn-aut-name=福井由美 kn-aut-sei=福井 kn-aut-mei=由美 aut-affil-num=6 ORCID= en-aut-name=IgaMayumi en-aut-sei=Iga en-aut-mei=Mayumi kn-aut-name=伊賀真由美 kn-aut-sei=伊賀 kn-aut-mei=真由美 aut-affil-num=7 ORCID= en-aut-name=KurodaAkiko en-aut-sei=Kuroda en-aut-mei=Akiko kn-aut-name=黒田昭子 kn-aut-sei=黒田 kn-aut-mei=昭子 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 en-keyword=温水プール水泳訓練 (swimming training in a hot spring pool) kn-keyword=温水プール水泳訓練 (swimming training in a hot spring pool) en-keyword=呼吸器疾患 (respiratory disease) kn-keyword=呼吸器疾患 (respiratory disease) en-keyword=慢性疼痛性疾患 (chronic pain disease) kn-keyword=慢性疼痛性疾患 (chronic pain disease) END start-ver=1.4 cd-journal=joma no-vol=121 cd-vols= no-issue=1 article-no= start-page=25 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A surgical case of small intestinal anisakiasis with symptoms of ileus kn-title=イレウス症状で発症した小腸アニサキス症の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report a surgical case of intestinal anisakiasis in which we identified a complete larva. A 48-year-old man complaining of epigastralgia after eating roasted mackerel was admitted to the hospital with a diagnosis of ileus with peritonitis. Abdominal CT showed dilatation and partial thickening of the small intestine. An emergency operation was carried out. On laparotomy, severe stricture of the jejunum was revealed. The affected intestine was resected. A larva whose head was invading the mucosa was found in the resected portion of the jejunum, and we diagnosed the case as intestinal anisakiasis. en-copyright= kn-copyright= en-aut-name=FujiiSayaka en-aut-sei=Fujii en-aut-mei=Sayaka kn-aut-name=藤井清香 kn-aut-sei=藤井 kn-aut-mei=清香 aut-affil-num=1 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=2 ORCID= en-aut-name=HamanoRyousuke en-aut-sei=Hamano en-aut-mei=Ryousuke kn-aut-name=濱野亮輔 kn-aut-sei=濱野 kn-aut-mei=亮輔 aut-affil-num=3 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=徳永尚之 kn-aut-sei=徳永 kn-aut-mei=尚之 aut-affil-num=4 ORCID= en-aut-name=TsunemitsuYousuke en-aut-sei=Tsunemitsu en-aut-mei=Yousuke kn-aut-name=常光洋輔 kn-aut-sei=常光 kn-aut-mei=洋輔 aut-affil-num=5 ORCID= en-aut-name=OotsukaShinya en-aut-sei=Ootsuka en-aut-mei=Shinya kn-aut-name=大塚眞哉 kn-aut-sei=大塚 kn-aut-mei=眞哉 aut-affil-num=6 ORCID= en-aut-name=MiyoshiKazuya en-aut-sei=Miyoshi en-aut-mei=Kazuya kn-aut-name=三好和也 kn-aut-sei=三好 kn-aut-mei=和也 aut-affil-num=7 ORCID= en-aut-name=TakahashiMasahiko en-aut-sei=Takahashi en-aut-mei=Masahiko kn-aut-name=高橋正彦 kn-aut-sei=高橋 kn-aut-mei=正彦 aut-affil-num=8 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=稲垣優 kn-aut-sei=稲垣 kn-aut-mei=優 aut-affil-num=9 ORCID= en-aut-name=OosakiToshihide en-aut-sei=Oosaki en-aut-mei=Toshihide kn-aut-name=大崎俊英 kn-aut-sei=大崎 kn-aut-mei=俊英 aut-affil-num=10 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=4 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=5 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=6 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=7 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=8 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=9 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=10 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=11 en-affil= kn-affil=国立病院機構福山医療センター　外科 en-keyword=小腸アニサキス症 （small intestinal anisakiasis） kn-keyword=小腸アニサキス症 （small intestinal anisakiasis） en-keyword=イレウス （ileus） kn-keyword=イレウス （ileus） END start-ver=1.4 cd-journal=joma no-vol=28 cd-vols= no-issue= article-no= start-page=17 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=200612 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Toward Understanding of Regional Climate in East Asia around the Last Glacial Maximum with Attention to the Seasonal Cycle and Daily Meteorological Systems kn-title=東アジアの季節サイクルや日々の気象に注目した最終氷期頃の気候環境の理解へ向けて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Regional climate system in East Asia shows the characteristic seasonal cycle affected by the Asian monsoon with various types of its sub-systems. The seasonal cycle there is also related greatly to behaviors of the frontal zones which are the boundaries of these sub-systems. Since the variation of global-scale environment such as the global warming influences on each monsoon sub-system in rather different manner, it is necessary to understand the joint effects of these subsystems, in order to predict the regional climate change in East Asia in the global warming. In such research, it would be also useful to examine the features in the ice age, as an opposite extreme situation against the global warming. Thus the present paper will discuss some viewpoints in investigating the regional climate in the Last Glacial Maximum with attention to the seasonal cycle and daily meteorological systems. en-copyright= kn-copyright= en-aut-name=KatoKuranoshin en-aut-sei=Kato en-aut-mei=Kuranoshin kn-aut-name=加藤内藏進 kn-aut-sei=加藤 kn-aut-mei=内藏進 aut-affil-num=1 ORCID= en-aut-name=IkedaShoichiro en-aut-sei=Ikeda en-aut-mei=Shoichiro kn-aut-name=池田祥一郎 kn-aut-sei=池田 kn-aut-mei=祥一郎 aut-affil-num=2 ORCID= en-aut-name=AbeKana en-aut-sei=Abe en-aut-mei=Kana kn-aut-name=阿部加奈 kn-aut-sei=阿部 kn-aut-mei=加奈 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学教育学部理科教室 affil-num=2 en-affil= kn-affil=岡山大学大学院自然科学研究科先端基礎科学専攻 affil-num=3 en-affil= kn-affil=岡山大学教育学部理科教室 en-keyword=Climate in East Asia kn-keyword=Climate in East Asia en-keyword=Seasonal cycle kn-keyword=Seasonal cycle en-keyword=Frontal zone kn-keyword=Frontal zone en-keyword=Last Glacial Maximum kn-keyword=Last Glacial Maximum END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=6 article-no= start-page=655 end-page=664 dt-received= dt-revised= dt-accepted= dt-pub-year=1966 dt-pub=19660630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=腫瘍ウイルスの電顕的研究 第2編 C3H系マウスに自然発生した乳癌のウイルス粒子に関する電子顕微鏡的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Spontaneous mammary carcinoma of C3H mice was studied by electron microscopy. Cancer cells showed prominent nucleoli and increased nucleocytoplasmic ratio, containing a few mitochondria, vacuoles, and endoplasmic reticulum in the cytoplam. There were inclusion bodies in some of cancer cells. Mature virus particles were seen in the lumina of the milk ducts, intercellular space and intracytoplasmic vacuoles. They were round in shape and composed of an eccentrically-located, electron-dense nucleoid containd in a triple-layered shell ranging 100 to 120 mμ in diameter. It was demonstrated that the outermost layer of the shell consists of numerons 100 Å spines. This finding is closely consistent with the negative contrast figure of the mature virus particles. A new interpretation of type A particles was also presented. en-copyright= kn-copyright= en-aut-name=IkedaKazuhiko en-aut-sei=Ikeda en-aut-mei=Kazuhiko kn-aut-name=池田一彦 kn-aut-sei=池田 kn-aut-mei=一彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=1-2 article-no= start-page=165 end-page=176 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Magnetic resonance image database system and its clinical applications kn-title=MR 画像データベースシステムの開発とその臨床応用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A magnetic resonance (MR) image detabase system has been developed. The purpose of this paper is to present this system and its application. It consists of an image processing system and database system to handle data of clinical cases and a medical knowledge base. Using the image processing system and the database system with stored data of clinical cases, the MR image data of cases can be retrieved by diagnosis as well as ID number, patient's name, etc., and MR images can be processed. By using the database system with the medical knowledge base, differential diagnoses can be offered. en-copyright= kn-copyright= en-aut-name=NoriyasuToshiaki en-aut-sei=Noriyasu en-aut-mei=Toshiaki kn-aut-name=則安俊昭 kn-aut-sei=則安 kn-aut-mei=俊昭 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 en-keyword=MRI kn-keyword=MRI en-keyword=database kn-keyword=database en-keyword=medical image kn-keyword=medical image en-keyword=knowledge base kn-keyword=knowledge base en-keyword=PACS kn-keyword=PACS END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=11-12 article-no= start-page=1253 end-page=1265 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effect of new elemental diet including enriched branched chain amino acids and MCT on massive resection of small bowel in rat kn-title=脂肪（MCT）および高濃度分枝鎖アミノ酸を含有した成分栄養剤の侵襲下における効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effects of a new enteral diet (ED-9) that was mainly composed of BCAA enriched amino acids, MCT and maltose were examined. Rats were subjected to small bowel resection and were administered two different formula for 7 days. The animals were divided into the following four groups : Sham operation and ED-9 (Group A), sham operation and control diet (Elental) (Group B), small bowel resection and ED-9 (Group C), and small bowel resection and control diet (Group D). Body weight loss after operation was similar in both ED-9 and control diet groups. Nitrogen balance and uninary 3 Methy1-histidine excretion demonstrated that ED-9 tended to improve protein preservation. Rats given ED-9 showed elevated ketone bodies and plasma BCAA level but these levels were not extraordinarily high. In conclusion, the formula of enteral nutrition (ED-9) was as effective as Elental on postoperative nutrition in rats. en-copyright= kn-copyright= en-aut-name=SuehiroKazunaga en-aut-sei=Suehiro en-aut-mei=Kazunaga kn-aut-name=末廣和長 kn-aut-sei=末廣 kn-aut-mei=和長 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=成分栄養剤 kn-keyword=成分栄養剤 en-keyword=手術侵襲 kn-keyword=手術侵襲 en-keyword=MCT kn-keyword=MCT END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=11-12 article-no= start-page=1193 end-page=1205 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical significance of body surface mapping for a diagnosis of left ventricular hypertrophy : Special reference to a differential diagnosis between hypertrophic cardiomyopathy and hypertension-induced left ventricular hypertrophy kn-title=体表面電位図による心肥大の病態の推定と鑑別診断―特に肥大型心筋症と高血圧性肥大心の鑑別診断を中心に― en-subtitle= kn-subtitle= en-abstract= kn-abstract=The present study was conducted to clarify electrophysiological characteristics of left ventricular hypertrophy (LVH) and to discriminate hypertrophic cardiomyopathy (HCM) from hypertension-induced LVH with body surface mapping. QRS area map, QRST area map and VAT map of body surface mapping were recorded on 37 patients with HCM, 37 with essential hypertension (EH) and 21 with aortic regurgitation (AR) using Yamada's method. HCM, EH and AR showed similar patterns of QRS area map. However, the maximum points of QRST area map located at the midsternal line (E5) in HCM, and positioned on the left midclavicular line (G4) in EH and AR. The minimum point of the QRST area map appeared at the left midclavicular line (G3) where the maximum point of the QRS area map was located. These findings indicate that the QRST area map would enable to differentiate HCM from EH and AR. With the VAT map, AR showed closed isochrone lines on the left precordium, which indicated delayed ventricular activation in this region. Statistical analysis revealed that the value of the maximum point of the QRST area (Max. QRST) and the sum of values of the positive QRST area (∑ positive QRST area) differentiates HCM from EH. When the Max. QRST was 0.6μVs or less and the ∑ positive QRST area was 14μVs or less, the diagnostic accuracy of HCM could be made more than 70%. These findings suggested that the diagnostic criteria derived from the QRST area map is of use to distinguish HCM from hypertension-induced LVH. en-copyright= kn-copyright= en-aut-name=MatsubaraKatashi en-aut-sei=Matsubara en-aut-mei=Katashi kn-aut-name=松原堅 kn-aut-sei=松原 kn-aut-mei=堅 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部循環器内科学教室 en-keyword=Hypertrophic cardiomyopaty kn-keyword=Hypertrophic cardiomyopaty en-keyword=Hypertensive left ventricular hypertrophy kn-keyword=Hypertensive left ventricular hypertrophy en-keyword=Body surface mapping kn-keyword=Body surface mapping END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=4 article-no= start-page=373 end-page=386 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical study on idiopathic thrombocytopenic purpura (ITP) Part 2. Analysis of the treatment of ITP and the value of colchicine therapy for the steroid resistant ITP kn-title=特発性血小板減少性紫斑病 (ITP)に関する臨床的研究 第2編 ITP の治療効果の解析とステロイド難反応性ITPに対するコルヒチン療法の意義について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clinical effects of steroid and colchicine therapy in 49 patients with ITP especially the refractory cases were evaluated in comparison with splenectomy and danazol therapy. There were 27(55%) steroid resistant patients who could not maintain platelet counts of 5×10(4)/μl with prednisolone doses of less than 10mg/day. Among the 16 steroid resistant patients treated with colchicine, there were 3 patients with complete remission and 3 others who had good to excellent response, that is, 6(37.5%) improved overall. This therapy was more effective than splenectomy (33.3%) and danazol (25%). Colchicine was did not effective in patients who did not respond to prednisolone, but was useful when patients showed at least a transient rise of the platelet count with prednisolone. In many cases, a response to colchicine was seen after a month, and in the patients who failed to show a rise in the platelet count after 2 months of colchicine therapy, no benefit was seen even when the therapy was continued. Colchicine is advantageous in the treatment of the steroid resistant ITP over the immunosuppressive agents or high-dose γ-globulin that are expensive and produce only a transient rise in the platelet count. en-copyright= kn-copyright= en-aut-name=TsurumiNaokazu en-aut-sei=Tsurumi en-aut-mei=Naokazu kn-aut-name=鶴見尚和 kn-aut-sei=鶴見 kn-aut-mei=尚和 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=steroid resistant ITP kn-keyword=steroid resistant ITP en-keyword=colchicine kn-keyword=colchicine en-keyword=danazol kn-keyword=danazol en-keyword=splenectomy kn-keyword=splenectomy END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=1-2 article-no= start-page=23 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Medico-legal aspects of traumatic injures-Rrport of 13 autopsy cases- kn-title=損傷の法医学的考察―司法解剖13例について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this paper we present 13 autopsy cases on interest in medico-legal traumatology. The cases are as follows : 1)two cases of incomplete cardiac rupture dur to thoracic trauma, 2)rupture of herniated large intestine due to abdominal trauma, 3)large incised wounds on the side of the neck by a small kitchen knife, 4)a homicidal case with similar wounds that accompanied self-inflicted wounds, 5)a homicidal case accompanied by multiple stab wounds on the chest, 6)an accidental death skewered by a slender metallic stick, 7)special fatal shotgun injuries, 8)a homicidal case accompanid by various burns by an electric hair-dryer, iron and ciga-rettes, 9)two murder cases by a metallic baseball bat, 10)a suicidal case due to a fall from a high place, and 11)a severely disrupted victim of a road traffic accident. en-copyright= kn-copyright= en-aut-name=NanikawaRyo en-aut-sei=Nanikawa en-aut-mei=Ryo kn-aut-name=何川凉 kn-aut-sei=何川 kn-aut-mei=凉 aut-affil-num=1 ORCID= en-aut-name=HashimotoYoshiaki en-aut-sei=Hashimoto en-aut-mei=Yoshiaki kn-aut-name=橋本良明 kn-aut-sei=橋本 kn-aut-mei=良明 aut-affil-num=2 ORCID= en-aut-name=MoriyaFumio en-aut-sei=Moriya en-aut-mei=Fumio kn-aut-name=守屋文夫 kn-aut-sei=守屋 kn-aut-mei=文夫 aut-affil-num=3 ORCID= en-aut-name=MiyaishiSatoru en-aut-sei=Miyaishi en-aut-mei=Satoru kn-aut-name=宮石智 kn-aut-sei=宮石 kn-aut-mei=智 aut-affil-num=4 ORCID= en-aut-name=NakaiMiyoko en-aut-sei=Nakai en-aut-mei=Miyoko kn-aut-name=中井三代子 kn-aut-sei=中井 kn-aut-mei=三代子 aut-affil-num=5 ORCID= en-aut-name=YangXu en-aut-sei=Yang en-aut-mei=Xu kn-aut-name=徐揚 kn-aut-sei=徐 kn-aut-mei=揚 aut-affil-num=6 ORCID= en-aut-name=GuoChun Gang en-aut-sei=Guo en-aut-mei=Chun Gang kn-aut-name=郭春鋼 kn-aut-sei=郭 kn-aut-mei=春鋼 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部法医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部法医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部法医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部法医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部法医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部法医学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部法医学教室 en-keyword=Criminal injuries kn-keyword=Criminal injuries en-keyword=Injuries and utensils kn-keyword=Injuries and utensils en-keyword=Traumatic injuries kn-keyword=Traumatic injuries en-keyword=Medico-legal traumatology kn-keyword=Medico-legal traumatology END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=1-2 article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of non-specific multiple ulcers of the small intestine -Review of the Japanese Literature- kn-title=腸閉塞を初発症状とする非特異性多発性小腸潰瘍の一例―本邦報告95例の検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Non-specific multiple ulcers of the small intestine is one of the new disease entities, differing from Crohn's disease and simple ulcers of the small intestine. The clinical course of this disease ia still poorly understood, and the factors which inflence the progression or healing of these lesions remain unknown. We reviewed 95 cases of non-specific multiple ulcers of the small intestine in the Japanese literature. Non-specific multiple ulcers were seen primarily in young adults, although our patient was a 73 year-old female. The main symptoms of this disease included occult blood in the stool, anemia, hypoproteinemia, abdominal pain and ileus. Our case was accompanied by ileus at the onset without anemia and hypoproteinemia. Almost all of the patients have a clinical course of long duration. Macroscopic examinations in this disease are characterized by multipe shallow ulcers (UL-I-II) developing crosswise or obliquely on the intestinal mucosa and several areas of stenosis. No cases of perforation, fisula fornation, obstruction or abscess were noted. The recurrence rate was 26.3%. en-copyright= kn-copyright= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=1 ORCID= en-aut-name=YunokiSho en-aut-sei=Yunoki en-aut-mei=Sho kn-aut-name=柚木昌 kn-aut-sei=柚木 kn-aut-mei=昌 aut-affil-num=2 ORCID= en-aut-name=HiguchiYasuhiko en-aut-sei=Higuchi en-aut-mei=Yasuhiko kn-aut-name=樋口康彦 kn-aut-sei=樋口 kn-aut-mei=康彦 aut-affil-num=3 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=4 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=5 ORCID= en-aut-name=HorieYasushi en-aut-sei=Horie en-aut-mei=Yasushi kn-aut-name=堀江靖 kn-aut-sei=堀江 kn-aut-mei=靖 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=ひぐち病院 affil-num=2 en-affil= kn-affil=ひぐち病院 affil-num=3 en-affil= kn-affil=ひぐち病院 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院病理部 en-keyword=非特異性多発性小腸潰瘍 kn-keyword=非特異性多発性小腸潰瘍 en-keyword=腸閉塞 kn-keyword=腸閉塞 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=4 article-no= start-page=293 end-page=303 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The level of lipid peroxide and the effect of human superoxide dismutase on cardiac ischemia/reperfusion injury kn-title=心筋虚血・再灌流障害における過酸化脂質の動態と h-SOD 投与効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the role of free radicals and the efficacy of human superoxide dismutase (h-SOD) on cardiac ischemia/reperfusion injury, adult mongrel dogs were placed on a cardiopulmonary bypass (CPB). Aorta was cross clamped for 120 minutes and crystalloid cardioplegic solution was administered into the aortic root every 30 minutes. Sixteen dogs were divided into the control group and non cross clamped group (XCL(-)group). They were placed on total CPB for 130 minutes without an aortic cross clamp. The control group showed higher thiobarbituric acid reactive substance (TBARS) release from heart in early reperfusion phase (P<0.05), and suppressed recovery of cardiac index (CI) and max dp/dt at 60 minutes after reperfusion (P<0.01 and P<0.05, respectively) than XCL (-) group. Eight dogs were administered saline and 32 dogs were administered saline and h-SOD into the aortic root just before reperfusion. Dogs, administered h-SOD, were devided into four groups by the dese of h-SOD, group I : 1mg/kg, group II : 3mg/kg, group III : 10mg/kg, and group IV : 20mg/kg. Between control and saline groups, no significant difference was found. Groups I and II showed suppressed TBARS release from the heart in the early reperfusion phase than the control group (P<0.01 and P<0.05, respectively). Groups II and III showed higher recovery of CI at 60 minutes after reperfusion than the control group (P<0.01 and P<0.05, respectively). In conclusion, significantly higher TBARS was released from the heart and recovery of cardiac function was suppressed in cardiac ischemia/reperfusion injury. The h-SOD administtation was effective to protect the heart from cardiac ischemia/reperfusion injury. en-copyright= kn-copyright= en-aut-name=IkedaEiji en-aut-sei=Ikeda en-aut-mei=Eiji kn-aut-name=池田英二 kn-aut-sei=池田 kn-aut-mei=英二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=体外循環 kn-keyword=体外循環 en-keyword=心筋保護 kn-keyword=心筋保護 en-keyword=再灌流障害 kn-keyword=再灌流障害 en-keyword=TBA kn-keyword=TBA en-keyword=h-SOD kn-keyword=h-SOD END start-ver=1.4 cd-journal=joma no-vol=2007 cd-vols= no-issue= article-no= start-page=1 end-page=88 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20081218 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Bulletin of Archaelogical Research Center Okayama University 2007 kn-title=岡山大学埋蔵文化財調査研究センター紀要2007 en-subtitle= kn-subtitle= en-abstract= kn-abstract=第１章　津島岡大遺跡の調査研究　　　 第２章　鹿田遺跡の調査研究　　　 第３章　構内遺跡の調査研究　　　 第４章　調査資料の整理・研究および公開・活用　　　 第５章　2007年度における調査・研究のまとめ　　　 付　編 en-copyright= kn-copyright= en-aut-name=NozakiTakahiro en-aut-sei=Nozaki en-aut-mei=Takahiro kn-aut-name=野崎貴博 kn-aut-sei=野崎 kn-aut-mei=貴博 aut-affil-num=1 ORCID= en-aut-name=MitsumotoJun en-aut-sei=Mitsumoto en-aut-mei=Jun kn-aut-name=光本順 kn-aut-sei=光本 kn-aut-mei=順 aut-affil-num=2 ORCID= en-aut-name=IwasakiShiho en-aut-sei=Iwasaki en-aut-mei=Shiho kn-aut-name=岩﨑志保 kn-aut-sei=岩﨑 kn-aut-mei=志保 aut-affil-num=3 ORCID= en-aut-name=YamamotoEtsuyo en-aut-sei=Yamamoto en-aut-mei=Etsuyo kn-aut-name=山本悦世 kn-aut-sei=山本 kn-aut-mei=悦世 aut-affil-num=4 ORCID= en-aut-name=IkedaSusumu en-aut-sei=Ikeda en-aut-mei=Susumu kn-aut-name=池田晋 kn-aut-sei=池田 kn-aut-mei=晋 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=9-10 article-no= start-page=1081 end-page=1088 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinicopathological studies on pm-colorectal carcinoma kn-title=大腸 pm 癌の臨床病理学的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=During the 13 years from 1978 to 1990, 50 cases of colorectal cancer, infiltrating to the proper muscle layer, were experienced, and were evaluated on the basis of clinicopathological findings. Pm colorectal carcinoma were classified into two groups (pm1,pm2) according to the depth of invasion into the proper muscle layer. Most of the pm colorectal carcinomas were located in the rectum (64%). According to macroscopic classification, the ulcerative type occurred more often (84%) than the elevated type (16%). As the carcinoma invaded deeper into the proper muscle layer, the incidence of lymphatic vessel invasion tended to become higher. Lymphnode metastasis from the ulcerative type cancer (26.2%) was less frequent than that of the elevated type (62.5%). Lymphnode metastasis from the elevated type cancer was confined to the n2 lymphnode. On the other hand, lymphnode metastasis from the ulcerative type had invaded to the n3 lymphnode. These findings indicated that R3 operation is needed for pm colorectal cancer of both the elevated and the ulcerative type, although nerve preserving operation or selective lateral lymphnode dissection is reasonable for pm rectal cancer. en-copyright= kn-copyright= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=1 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=2 ORCID= en-aut-name=MatsubaraNagahide en-aut-sei=Matsubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=3 ORCID= en-aut-name=ShiikiShigeo en-aut-sei=Shiiki en-aut-mei=Shigeo kn-aut-name=椎木滋雄 kn-aut-sei=椎木 kn-aut-mei=滋雄 aut-affil-num=4 ORCID= en-aut-name=HamadaFumihiro en-aut-sei=Hamada en-aut-mei=Fumihiro kn-aut-name=浜田史洋 kn-aut-sei=浜田 kn-aut-mei=史洋 aut-affil-num=5 ORCID= en-aut-name=GouchiAkira en-aut-sei=Gouchi en-aut-mei=Akira kn-aut-name=合地明 kn-aut-sei=合地 kn-aut-mei=明 aut-affil-num=6 ORCID= en-aut-name=KamikawaYasuaki en-aut-sei=Kamikawa en-aut-mei=Yasuaki kn-aut-name=上川康明 kn-aut-sei=上川 kn-aut-mei=康明 aut-affil-num=7 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=8 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=9 ORCID= en-aut-name=MizobuchiKoichi en-aut-sei=Mizobuchi en-aut-mei=Koichi kn-aut-name=溝淵光一 kn-aut-sei=溝淵 kn-aut-mei=光一 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=9 en-affil= kn-affil=中電病院 affil-num=10 en-affil= kn-affil=香川労災病院病理部 en-keyword=大腸 pm 癌 kn-keyword=大腸 pm 癌 en-keyword=リンパ節転移 kn-keyword=リンパ節転移 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=9-10 article-no= start-page=1075 end-page=1079 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical analysis of colorectal cancer with invasion to the adjacent organs kn-title=大腸癌他臓器浸潤症例の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The clinicopathologic features of 39 cases of colorectal cancer with invasion to the adjacent organs (si,ai) were studied. Twenty seven were cases with combined resection of involved organs. Twenty two and 17 cases were located in colon and rectum, respectively. The D region was mostly involved, followed by, the C and T region. Five cases had invasion to the gastrointestinal tract, 2 cases had invasion to the liver, gall bladder or pancreas. Twenty one cases had urogenital organ invasion and 11 cases had invasion to sacrum and other organs. The survival rate of cases with combined resection of the involved organs was significantly high compared with non-resection. Also, the survival rate of curative resection was significantly high compared with non-curative resection. Aggressive resection of involved organs seems to be important for good prognosis. en-copyright= kn-copyright= en-aut-name=ShiikiShigeo en-aut-sei=Shiiki en-aut-mei=Shigeo kn-aut-name=椎木滋雄 kn-aut-sei=椎木 kn-aut-mei=滋雄 aut-affil-num=1 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=2 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=3 ORCID= en-aut-name=HamadaFumihiro en-aut-sei=Hamada en-aut-mei=Fumihiro kn-aut-name=浜田史洋 kn-aut-sei=浜田 kn-aut-mei=史洋 aut-affil-num=4 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=5 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=大腸菌 kn-keyword=大腸菌 en-keyword=他臓器浸潤 kn-keyword=他臓器浸潤 en-keyword=他臓器合併切除 kn-keyword=他臓器合併切除 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=11-12 article-no= start-page=1145 end-page=1158 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Histopathological study on the lesions of the cerebral cortex and the subcortical white matter in Neuro-Behçet's disease kn-title=Neuro-Behçet 病における大脳皮質,皮質下白質の病変 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Foci of tissue sponginess and necrosis in the cerebral cortex and the subcortical white matter were studied histopathologically in three cases of Neuro-Behçet's disease. The following results were obtained: Lesions in the cerebral cortex and the subcortical white matter were less severe than those in the brain stem. Though recent and older foci coexisted, glial scar foci were rare. Necrotic foci in the cerebral cortex and the subcortical white matter were vascular in origin. Foci were more numerous in the cerebral cortex than in the subcortical white matter. Foci were relatively numerous in the temporal lobe, especially in the hippocampus (Case 2), and were not so numerous in the frontal lobe. Mental symptoms such as hypospontaneity, blunted affect, euphoria, distrubance of immediate and recent memory, forced laughing and crying and bradyphrenia are attributable to brain stem lesions, but some cases of Neuro-Behçet's disease with numerous necrotic foci in the hippocampus and adjacent structures are believed to have hippocampal amnesia superimosed on brain stem symptoms. en-copyright= kn-copyright= en-aut-name=OhbayashiMasakazu en-aut-sei=Ohbayashi en-aut-mei=Masakazu kn-aut-name=大林正和 kn-aut-sei=大林 kn-aut-mei=正和 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=Neuro-Behçet's disease kn-keyword=Neuro-Behçet's disease en-keyword=microspongy state of the cerebral cortex kn-keyword=microspongy state of the cerebral cortex en-keyword=subcortical white matter change kn-keyword=subcortical white matter change END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=11-12 article-no= start-page=1127 end-page=1134 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effect of human superoxide dismutase on reperfusion injury in clinical cases kn-title=h-SOD による心筋虚血後再灌流障害抑制効果についての臨床的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In valve replacement surgery, human superoxide dismutase (h-SOD) was administered just before reperfusion, and the effect of h-SOD on reperfusion injury was studied. Release of cardiac enzymes (CPK-MB and HBD), increase of left ventricular volume, and recovery rate of cardiac function were measured. The release of the enzymes during 60 minutes after reperfusion in the group receiving h-SOD (3mg/kg) was less than that of the control (without h-SOD)group (p<0.01). Myocardial edema (volume increase) was also reduced by h-SOD (1mg/kg or 3mg/kg : p<0.01). Recovery of cardiac function after reperfusion of the h-SOD group was better than that of the control group. In conclusion, h-SOD can protect the myocardium from reperfusion injury and accelerate the rate of recovery of cardiac function after global ischemia. en-copyright= kn-copyright= en-aut-name=TakataKouji en-aut-sei=Takata en-aut-mei=Kouji kn-aut-name=高田耕二 kn-aut-sei=高田 kn-aut-mei=耕二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=再灌流障害 kn-keyword=再灌流障害 en-keyword=h-SOD kn-keyword=h-SOD en-keyword=心筋浮腫 kn-keyword=心筋浮腫 en-keyword=心筋保護 kn-keyword=心筋保護 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=11-12 article-no= start-page=1059 end-page=1068 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of myocardial damage and cardiac residual capacity by Tl-201 myocardial scintigraphy in valvular heart diseases kn-title=Tl-201心筋シンチグラフィーを用いた心臓弁膜症における心筋性状及び心予備能の評価 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study was performed to clarify whether the extent-score (Ex-Score) calculated by Tl-201 myocardial scintigraphy is a reliable indicator of the severity of myocardial damage and cardiac residual capacity in valvular heart diseases. The subjects consisted of 38 patients (10 with aortic regurgitation (AR), 4 with aortic stenosis (AS), 13 with mitral regurgitation (MR) and 11 with mitral stenosis (MS)). Ex-Score were significantly correlated with the severity of myocardial damage found in biopsied specimens obtained intraoperatively (correlation efficiency to Ex-Score with cell diameter in AR, % fibrosis in AR, cell diameter in AS, electron microscopic score in MR and % fibrosis in MS was 0.873, 0.734, 0.970, 0.913 and 0.659, respectively). Ex-Score were also correlated with cardiac residual capacity determined by radioisotope angiography (correlation efficiency to Ex-Score with % ⊿ ejection fraction in AR, % ⊿ end-systolic volume in MR, % ⊿ end-diastolic volume in MS was -0.764, 0.790 and -0.763, respectively). These results suggest that the severity of myocardial damage and cardiac residual capacity can be estimated by Tl-201 myocardial scintigraphy (Ex-Score) in valvular heart diseases. en-copyright= kn-copyright= en-aut-name=IndoShunju en-aut-sei=Indo en-aut-mei=Shunju kn-aut-name=因藤春秋 kn-aut-sei=因藤 kn-aut-mei=春秋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=Tl-201心筋シンチグラフィー kn-keyword=Tl-201心筋シンチグラフィー en-keyword=Extent Score kn-keyword=Extent Score en-keyword=心筋間線維量 kn-keyword=心筋間線維量 en-keyword=心筋細胞横径 kn-keyword=心筋細胞横径 en-keyword=電顕スコア kn-keyword=電顕スコア END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=9-10 article-no= start-page=931 end-page=941 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Thermographic findings as a prognostic indicator for breast cancer : Correlation between temperature increase and angioarchitecture kn-title=乳癌サーモグラフｨ所見と予後の検討;サーモグラフｨにおける温度上昇と血管構築の変化 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The thermographic findings of 191 patients with Satges I-III breast cancer were retrospectively evaluated to determine the prognostic indicators of disease-free survival in both the whole study population and in each histological stage. The angioarchitecture of 75 breast cancer specimens was subsequently examined morphometrically using an immunohistochemical method, and was then compared with the extent of increase in the temperature at the tumor site. The extent of increase in the temperature was more closely related to the prognosis than was the thermal pattern. In stage II cancer (n=57), patients with lesions that showed a temperature increase > 1.5℃ had a poorer prognosis than the patients with hypothermic regions. (p<0.05). The range of skin temperature elevation at the tumor site correlated with the vascular changes in the skin above the tumor rather than with changes within or around the tumor in all of the patients. The increase in temperature above a tumor was concluded to be useful for assessing the prognosis and the grade of malignancy of breast cancer. The skin blood flow was also suggested to have the closest relationship with thermographic findings and the extent of the increase in blood flow to be a prognostic indicator for breast cancer. en-copyright= kn-copyright= en-aut-name=MurakamiMasakazu en-aut-sei=Murakami en-aut-mei=Masakazu kn-aut-name=村上正和 kn-aut-sei=村上 kn-aut-mei=正和 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=Thermography kn-keyword=Thermography en-keyword=Breast cancer kn-keyword=Breast cancer en-keyword=Prognostic factor kn-keyword=Prognostic factor en-keyword=Malignant grade kn-keyword=Malignant grade en-keyword=Angioarchitecture kn-keyword=Angioarchitecture END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=117 end-page=127 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on pulmonary granuloma formation by Propionibacterium acnes in sarcoidosis Part 1. Interleukin-2 production and receptor expression of alveolar lymphocytes stimulated by Propionibacterium acnes in sarcoidosis kn-title=サルコイドーシスの肺肉芽腫形成に対する Propionibacterium acens の関与に関する研究　第1編　サルコイドーシス肺胞リンパ球のPropionibacterium acens に対する Interleukin-2 産生及び Interleukin-2　受容体発現のついて en-subtitle= kn-subtitle= en-abstract= kn-abstract=We previously reported that alveolar lymophocytes in patients with active sarcoidosis are sensitized Propionibacterium acnes (P. acnes) which may play a significant role in the induction of alveolitis in these patients. We further investigated the production of Interleukin-2 (IL-2), and the responsiveness to IL-2 of alveolar lymphocytes obtained from sarcoidosis patients and stimulated by P. acnes in vitro. In 21 untreated sarcoidosis patients, 7 treated patients and 13 control subjects, the mean IL-2 activity of fluid released from cultured alveoloar lymphocytes was 9.8±15.7 (M±SD), 1.9±4.7 and 0.2±0.8 u/ml respectively. The IL-2 activity of lymphocytes from untreated patients was significantly higher than that of control subjects (p<0.02). Neither perioheral lymphocytes in sarcoidosis patients nor in controls produced IL-2 stimulated by P. acnes. The responsiveness of alveloar lymphocytes to recombinant IL-2 was evaluated by 3H-thymidine uptake in the presence and absence of P. acnes. Lymphocytes stimulated by P. acnes showed a significantly increased uptake (3,766±3,929 dpm) compred to ustimulated lymphocytes (1,123±968 dpm) obtained from 11 untreated sarcoidosis patients (p<0.02). On the other hand, the responsiveness of lymphocytes obtained from 6 control subjects was low regardless of stimulation by P. acnes. There was a significant correlation (p<0.05) between the P. acnes-induced production of IL-2 by alveolar lymphocytes and the blastogenesis of alveloar lymphocytes in untreated sarcoidosis patietnes. Our findings indicate that P. acnes stimulated IL-2 production and IL-2 receptor induction in alveolar lymphocytes from patients with active sarcoidosis. This study supported our hypothesis that P. acnes could be an antigen causing sarcoidosis. en-copyright= kn-copyright= en-aut-name=MoriYoshihiro en-aut-sei=Mori en-aut-mei=Yoshihiro kn-aut-name=森由弘 kn-aut-sei=森 kn-aut-mei=由弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=sarcoidosis kn-keyword=sarcoidosis en-keyword=Propionibacterium acens kn-keyword=Propionibacterium acens en-keyword=Interleukin-2 kn-keyword=Interleukin-2 en-keyword=Interleukin-2 receptor kn-keyword=Interleukin-2 receptor en-keyword=alveolar lymphocyte kn-keyword=alveolar lymphocyte END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=841 end-page=857 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental study on the hepatic effects of sevoflurane anesthesia kn-title=セボフルレン麻酔の肝に及ぼす影響に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The hepatic effects of sevoflurane administered under different inspiratory oxygen concentrations were examined. Male rats pretreated with phenobarbital for 5 days and fasted for 24 hours were anesthetized with 2.4% sevoflurane administered under different oxygen concentrations (10%, 14%, 21% or 100%). The rats administered sevoflurane under 21% oxygen were used as the control. The amount of microsomal protein, the content and activity of hepatic microsomal enzymes, and the amount of enzymes released from the liver cells (GPT, OCT) of each group of rats were measured for 7 days after these procedures. The content of cytochrome P-450 and the activity of aminopyrine demethylation and aniline dehydration were decreased significantly to about 58%, 43% and 40% that of the control, respectively. Furthermore the plasma level of GPT and OCT was elevated to 1,107±620 IU/L and 422±270 IU/L respectively soon after sevoflurane anesthesia only in the group of rats administered sevoflurane under a 10% oxygen concentration. In this study, severe damage to the liver of the rats was observed after sevoflurane anesthesia under 10% oxygen following enzyme induction and fasting. en-copyright= kn-copyright= en-aut-name=OkadaNaoki en-aut-sei=Okada en-aut-mei=Naoki kn-aut-name=岡田尚起 kn-aut-sei=岡田 kn-aut-mei=尚起 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部麻酔・蘇生学教室 en-keyword=セボフルレン麻酔 kn-keyword=セボフルレン麻酔 en-keyword=吸入酸素濃度 kn-keyword=吸入酸素濃度 en-keyword=チトクローム　P-450 kn-keyword=チトクローム　P-450 en-keyword=肝障害 kn-keyword=肝障害 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=51 end-page=56 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinicopathological studies in patients with colorectal cancers without lymphnode metastasis kn-title=リンパ節転移を認めない大腸癌の臨床病理学的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The clinicopathologic findines and the prognosis of 154 patients without regional lymph nodes metastasis or distant metastasis (n(-)group) were compared with those in 134 patients with regional lymph nodes metastasis and without distant netastasis (n(+)group). The mean age of the n(-) group was significantly younger than that of the n(+) group (p<0.05) and there was no significant sexual preponderance. The proportion of the cases without lymphatic vessel invasion in the n(-) group was significantly higher than in the n(+) group (p<0.01). The proportion of the cases without venous invasion was significantly higher in the n(-) group than in the n(-) group (p<0.05). There was no difference in cumulative surval rate of patients in then(-) group than in the n(+) group (p<0.05). There was no difference in cumulative survial rate of patients in the n(-) group in respect to the background factors such as sex, tumor site, and venous invasion. However, the survial rate of patients whose cancer invasion was limited within the mucosa (m), submucosa (sm) and musclar propria (pm) was significantly better than that of patients who had subserosal or subadventitial penetration (ss(al)), serosal or adeventitial penetration (s(a2)) and cancer invasion adjacent organs (si(ai))(p<0.05). The survial rate of patients with lymphatic vessel invasion was significantly higher than that of patients without lymphatic vessel invasion (p<0.05). That the poor prognostic factors in n(-) colorectal cancer patients are cancer penetration to/beyond ss(al), or positive lymphatic vessal invasion. en-copyright= kn-copyright= en-aut-name=ShiikiShigeo en-aut-sei=Shiiki en-aut-mei=Shigeo kn-aut-name=椎木滋雄 kn-aut-sei=椎木 kn-aut-mei=滋雄 aut-affil-num=1 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=2 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=3 ORCID= en-aut-name=HamadaHiroshi en-aut-sei=Hamada en-aut-mei=Hiroshi kn-aut-name=浜田史洋 kn-aut-sei=浜田 kn-aut-mei=史洋 aut-affil-num=4 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=5 ORCID= en-aut-name=OiritaKunzo en-aut-sei=Oirita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=大腸癌 kn-keyword=大腸癌 en-keyword=リンパ節転移 kn-keyword=リンパ節転移 en-keyword=n(0) kn-keyword=n(0) END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=631 end-page=639 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on early lung cancer detected by mass acreening using annual chest radiograph Part 2. Radiographic features of early lung cancer kn-title=検診発見による早期肺癌の関する研究　第2編　早期X腺所見の関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the radiographic features of early lung cancer, the author investigated annual chest radiographs of 234 patients with lung cancer detected by mass screening. Abnormality could be detected on the previous radiographs in 79% of the patients when reviewed retrospec-tively. The causes for failing to detect the tumor on the previous examination were as follows : 1) It was too small or too faint to detect. 2) It overlapapped with other organs such as vessels or ribs or coexisted with the preceding pulmonary lesions. 3) In some instances, only a linear (non-tumorous) shadow was initially present on chest radiograph. These results indicate that systematic and careful reading of chest radiograph and compara-tive reading with the previous films are necessary, and that it is important to learn the causes for failing to detect the tumor shadow. en-copyright= kn-copyright= en-aut-name=MoriKosuke en-aut-sei=Mori en-aut-mei=Kosuke kn-aut-name=森公介 kn-aut-sei=森 kn-aut-mei=公介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Mass screening kn-keyword=Mass screening en-keyword=Lung cancer kn-keyword=Lung cancer en-keyword=Early chest x-ray findings kn-keyword=Early chest x-ray findings END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=721 end-page=733 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the mechanism and treatment of intractable asthma Part 1. Effects of a specific thromboxane A(2) synthetase inhibitor in lymphocyte and neutrophil functions in intractable asthmatics kn-title=難治性喘息の病態と治療に関する研究　第1編　難治性喘息患者のリンパ球および好中球機能に及ぼす選択的 Thromboxane A(2) 合成酵素阻害剤の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify whether thromboxane A(2) (TXA(2)) is involved in type III and IV allergy, so-called "cell-mediated allergy", the effects of a specific TXA(2) synthetase inhibitor, sodium ozagrel (OKY-046) on peripheral blood mononuclear cells and neutrophils in adult intractable asthmatics were studied. Lymphocyte blastogenesis and interleukin-2 (IL-2) production from peripheral blood mononuclear cells stimulated by PHA and Candida antigen in intractable asthmatics was significantly suppressed dose-dependently by OKY-046. The neutrophil chemotactic factor (NCF) and eosinophil chemotactic factor (ECF) from peripheral blood nomonuclear cells stimulated by Candida antigen in intractable asthmatics tended to be suppressed by OKY-046. Furthermore, leukotriene C(4) (LTC(4)) and superoxide (O(2)(-)) production from peripheral blood neutrophils in intractable asthmatics was significantly suppressed dose-dependently by OKY-046. These findings suggest that TXA(2) plays an important role in the development of intractable asthma and OKY-046, which has a suppressive effect on type IV allergy caused by lymphocyte activation and on mediator release from neutrophils, might be a useful drug in the treatment of intractalbe asthmatics. en-copyright= kn-copyright= en-aut-name=KanehiroArihiko en-aut-sei=Kanehiro en-aut-mei=Arihiko kn-aut-name=金廣有彦 kn-aut-sei=金廣 kn-aut-mei=有彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Intractable asthma kn-keyword=Intractable asthma en-keyword=cell-mediated allergy kn-keyword=cell-mediated allergy en-keyword=thromboxane A(2) kn-keyword=thromboxane A(2) en-keyword=thromboxane A(2) synthetase inhibitor (OKY-046) kn-keyword=thromboxane A(2) synthetase inhibitor (OKY-046) END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=621 end-page=629 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on early lung cancer detected by mass acreening using annual chest radiograph Part 1. Clinical features of early pulmonary adenocarcinoma kn-title=検診発見による早期肺癌の関する研究　第1編　早期腺癌の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=One-hundred-twelve patients with pulmonary adenocarcinoma 2cm or less in diameter on chest rediograph were found by mass screening between 1981 and 1989. Of these patients, 92 underwent surgical resection of the tumor. To detect early pulmonary adenocarcinoma more efficiently by mass screening using annual chest rediographs, clinical and radiographic features of the 92 patients were examined and the following results were obtained. 1) Twenty-nin patients with a tumor 1.5cm or less in diameter on the resected specimen were all in pathological atage I and the five-year survial rate was 100%. 2) In 63 patients with a tumor between 1.6cm and 2.0cm in diameter, the five-year survival rate was 83.5%. Of those, 6(13%) patients had advanced lung cancer, all of which could be detected on the previous chest radiograph by retrospective analysis. These results indicate that efforts to detect tumors 1.5cm or less in diametor are important to improving the efficiency of mass screening. For this purpose, it is necessary to obtain a chest radiograph of good quality and learn to identify the radiographic features of early pulmonary adenocarcinoma. en-copyright= kn-copyright= en-aut-name=MoriKosuke en-aut-sei=Mori en-aut-mei=Kosuke kn-aut-name=森公介 kn-aut-sei=森 kn-aut-mei=公介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Mass screening kn-keyword=Mass screening en-keyword=Early lung cancer kn-keyword=Early lung cancer en-keyword=Adeno carcinoma kn-keyword=Adeno carcinoma END