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neutrophil-to-lymphocyte ratio as an indicator of tumor immune status in non-small cell lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IWATAKazuma en-aut-sei=IWATA en-aut-mei=Kazuma kn-aut-name=岩田一馬 kn-aut-sei=岩田 kn-aut-mei=一馬 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ALK融合遺伝子陽性非小細胞肺癌に対するgilteritinibの有効性についての検討 kn-title=Efficacy of gilteritinib in comparison with alectinib for the treatment of ALK-rearranged non-small cell lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ANDOChihiro en-aut-sei=ANDO en-aut-mei=Chihiro kn-aut-name=安東千裕 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no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=CDK4/6シグナル伝達は、EGFR変異型非小細胞肺がんにおける上皮成長因子受容体チロシンキナーゼ阻害剤の効果を減弱させる kn-title=CDK4/6 signaling attenuates the effect of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HARANaofumi en-aut-sei=HARA en-aut-mei=Naofumi kn-aut-name=原尚史 kn-aut-sei=原 kn-aut-mei=尚史 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=PD-1阻害は、Egfr変異陽性肺癌においてAd-SGE-REICにより誘導されるCD8+T細胞依存性抗腫瘍免疫を増強する kn-title=PD-1 blockade augments CD8+ T cell dependent antitumor immunity triggered by Ad-SGE-REIC in Egfr-mutant lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NAKASUKATakamasa en-aut-sei=NAKASUKA en-aut-mei=Takamasa kn-aut-name=中須賀崇匡 kn-aut-sei=中須賀 kn-aut-mei=崇匡 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=集学的治療が行われた局所進行肺癌患者における末梢血好中球/リンパ球比（NLR)の予後的意義について kn-title=Prognostic Signi?cance of Neutrophil-to-Lymphocyte Ratio in Locally Advanced Non-small-cell Lung Cancer Treated with Trimodality Therapy en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TSUDAKAShimpei en-aut-sei=TSUDAKA en-aut-mei=Shimpei kn-aut-name=津慎平 kn-aut-sei=津 kn-aut-mei=慎平 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=低転移性サブクローン由来のエキソソームwnt7aは、murine 4t1乳がんの高度転移性サブクローンの肺転移を促進する kn-title=Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=LICHUNNING en-aut-sei=LI en-aut-mei=CHUNNING kn-aut-name=李春寧 kn-aut-sei=李 kn-aut-mei=春寧 aut-affil-num=1 ORCID= affil-num=1 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no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=OCT4A /SPP1C遺伝子共発現の早期肺腺癌における予後予測マーカーとしての意義 kn-title=Prognostic value of OCT4A and SPP1C transcript variant co-expression in early-stage lung adenocarcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KoshimuneSeijiro en-aut-sei=Koshimune en-aut-mei=Seijiro kn-aut-name=越宗靖二郎 kn-aut-sei=越宗 kn-aut-mei=靖二郎 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=YES1の活性化はHER2遺伝子増幅を有する乳がんおよび肺がんにおいてネラチニブ耐性を誘導する kn-title=YES1 activation 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dt-online= en-article= kn-article= en-subject= kn-subject= en-title=クリゾチニブ耐性ROS1融合遺伝子陽性肺癌に対するカボザンチニブとゲフィチニブの併用療法による効果 kn-title=Combined effect of cabozantinib and gefitinib in crizotinib-resistant lung tumors harboring ROS1 fusions en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KatoYuka en-aut-sei=Kato en-aut-mei=Yuka kn-aut-name=加藤有加 kn-aut-sei=加藤 kn-aut-mei=有加 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20181227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=線量体積因子は非小細胞肺癌に対する導入同時併用化学放射線療法おける術後の放射線肺臓炎を予測する kn-title=Dose-Volume Parameters Predict Radiation Pneumonitis after Surgery with Induction Concurrent Chemoradiotherapy for Non-small Cell Lung Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OgataTakeshi en-aut-sei=Ogata en-aut-mei=Takeshi kn-aut-name=尾形毅 kn-aut-sei=尾形 kn-aut-mei=毅 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ErbB抑制因子であるLRIG1のEGFR変異型非小細胞肺癌における腫瘍抑制効果 kn-title=Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TorigoeHidejiro en-aut-sei=Torigoe en-aut-mei=Hidejiro kn-aut-name=鳥越英次郎 kn-aut-sei=鳥越 kn-aut-mei=英次郎 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=EGFR遺伝子変異を有する進行非小細胞肺癌患者におけるInterleukin-6のgefitinibの治療効果における影響 kn-title=Potential influence of interleukin-6 on the therapeutic effect of gefitinib in patients with advanced non-small cell lung cancer harbouring EGFR mutations en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TamuraTomoki en-aut-sei=Tamura en-aut-mei=Tomoki kn-aut-name=田村朋季 kn-aut-sei=田村 kn-aut-mei=朋季 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170929 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=上皮間葉移行の特性を示すEGFR-TKI耐性非小細胞肺癌はmicroRNA200c/LIN28B系に依存する kn-title=Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SatoHiroki en-aut-sei=Sato en-aut-mei=Hiroki kn-aut-name=佐藤博紀 kn-aut-sei=佐藤 kn-aut-mei=博紀 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170929 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=vivoモデルでのEGFR T790M陽性肺癌においてアファチニブ, セツキシマブ, ベバシズマブの3剤併用療法は深い寛解をもたらす kn-title=Triplet therapy with afatinib, cetuximab and bevacizumab induces deep remission in lung cancer cells harboring EGFR T790M in vivo en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KudoKenichiro en-aut-sei=Kudo en-aut-mei=Kenichiro kn-aut-name=工藤健一郎 kn-aut-sei=工藤 kn-aut-mei=健一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170929 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=上皮成長因子受容体活性型変異及び融合遺伝子活性型変異を有する肺癌細胞におけるEGCGの効果 kn-title=Effects of (-)-epigallocatechin-3-gallate on　EGFR- or fusion gene-driven lung cancer cells en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HondaYoshihiro en-aut-sei=Honda en-aut-mei=Yoshihiro kn-aut-name=本多宣裕 kn-aut-sei=本多 kn-aut-mei=宣裕 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非小細胞肺癌細胞は代替受容体チロシンキナーゼの活性化によってALK阻害剤アレクチニブに耐性を獲得する kn-title=Non?Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IsozakiHideko en-aut-sei=Isozaki en-aut-mei=Hideko kn-aut-name=磯崎英子 kn-aut-sei=磯崎 kn-aut-mei=英子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=HER2肺癌におけるHER2を標的としたアファチニブの抗腫瘍効果 kn-title=Antitumor effect of afatinib, as a human epidermal growth factor receptor 2-targeted therapy, in lung cancers harboring HER2 oncogene alterations en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SuzawaKen en-aut-sei=Suzawa en-aut-mei=Ken kn-aut-name=諏澤憲 kn-aut-sei=諏澤 kn-aut-mei=憲 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺癌の進行に関与するmiR-19a標的遺伝子の同定 kn-title=Uncovering Direct Targets of MiR-19a Involved in Lung Cancer Progression en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YamamotoKumiko en-aut-sei=Yamamoto en-aut-mei=Kumiko kn-aut-name=山本久美子 kn-aut-sei=山本 kn-aut-mei=久美子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ゲフィチニブ耐性非小細胞肺癌におけるSrcを介したERK再活性化 kn-title=Src mediates ERK reactivation in gefitinib resistance in non-small cell lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OchiNobuaki en-aut-sei=Ochi en-aut-mei=Nobuaki kn-aut-name=越智宣昭 kn-aut-sei=越智 kn-aut-mei=宣昭 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=活性型上皮成長因子受容体肺癌モデルにおけるAZD1480の効果 kn-title=Effect of AZD1480 in an epidermal growth factor receptor-driven lung cancer model en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MurakamiToshi en-aut-sei=Murakami en-aut-mei=Toshi kn-aut-name=村上斗司 kn-aut-sei=村上 kn-aut-mei=斗司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=EGFR遺伝子変異陽性肺癌において低用量ゲフィチニブはT790M遺伝子変異出現前に早期獲得耐性を惹起する kn-title=Lower gefitinib dose led to earlier resistance acquisition before emergence of T790M mutation in epidermal growth factor receptor-mutated lung cancer model en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HayakawaHiromi en-aut-sei=Hayakawa en-aut-mei=Hiromi kn-aut-name=早川宏美 kn-aut-sei=早川 kn-aut-mei=宏美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=血清遊離DNAにおけるmicroRNA-34b/cのメチル化の度合いは悪性胸膜中皮腫と関連する kn-title=The degree of microRNA-34b/c methylation in serum-circulating DNA is associated with malignant pleural mesothelioma en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MuraokaTakayuki en-aut-sei=Muraoka en-aut-mei=Takayuki kn-aut-name=村岡孝幸 kn-aut-sei=村岡 kn-aut-mei=孝幸 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非小細胞肺癌細胞株における上皮性増殖因子受容体を標的としたモルフォリノ･オリゴマを用いたアンチセンス治療の効果 kn-title=The effect of epidermal growth factor receptor antisense morpholino oligomer on non-small cell lung cancer cell line en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WashioKazuhiro en-aut-sei=Washio en-aut-mei=Kazuhiro kn-aut-name=鷲尾一浩 kn-aut-sei=鷲尾 kn-aut-mei=一浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=PTEN欠失肺癌細胞株におけるPARP阻害剤とシスプラチンの相乗効果 kn-title=Synergistic Effect of Olaparib with Combination of Cisplatin on PTEN-Deficient Lung Cancer Cells en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MinamiDaisuke en-aut-sei=Minami en-aut-mei=Daisuke kn-aut-name=南大輔 kn-aut-sei=南 kn-aut-mei=大輔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=アファチニブは活性型上皮成長因子受容体肺癌モデルにおいてゲフィチニブよりも生存を延長する kn-title=Afatinib Prolongs Survival Compared with Gefitinib in an Epidermal Growth Factor Receptor-Driven Lung Cancer Model en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NinomiyaTakashi en-aut-sei=Ninomiya en-aut-mei=Takashi kn-aut-name=二宮崇 kn-aut-sei=二宮 kn-aut-mei=崇 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=バンテタニブはPTENを欠損したEGFR変異を有する肺癌細胞に有効である kn-title=Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakedaHiromasa en-aut-sei=Takeda en-aut-mei=Hiromasa kn-aut-name=武田洋正 kn-aut-sei=武田 kn-aut-mei=洋正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=小細胞肺癌におけるmicroRNA-34b/cのメチル化とその役割 kn-title=Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TanakaNorimitsu en-aut-sei=Tanaka en-aut-mei=Norimitsu kn-aut-name=田中則光 kn-aut-sei=田中 kn-aut-mei=則光 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非小細胞肺癌に対する導入化学放射線療法における予後因子としての癌幹細胞関連マーカー kn-title=Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SienKazuhiko en-aut-sei=Sien en-aut-mei=Kazuhiko kn-aut-name=枝園和彦 kn-aut-sei=枝園 kn-aut-mei=和彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=JAK2関連経路が、上皮成長因子受容体活性型変異を有する肺癌細胞においてエルロチニブ獲得耐性を誘導する kn-title=JAK2-related pathway induces acquired erlotinib resistance in lung cancer cells harboring an epidermal growth factor receptor-activating mutation en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HaradaDaijirou en-aut-sei=Harada en-aut-mei=Daijirou kn-aut-name=原田大二郎 kn-aut-sei=原田 kn-aut-mei=大二郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=CD133やCD87を発現している肺小細胞癌の細胞亜集団は化学療法に対して抵抗性を示す kn-title=Subpopulation of small-cell lung cancer cells expressing CD133 and CD87 show resistance to chemotherapy en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KuboToshio en-aut-sei=Kubo en-aut-mei=Toshio kn-aut-name=久保寿夫 kn-aut-sei=久保 kn-aut-mei=寿夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非小細胞肺癌に対する新規HSP90阻害薬NVP-AUY922の抗腫瘍効果の検討 kn-title=Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=UenoTsuyoshi en-aut-sei=Ueno en-aut-mei=Tsuyoshi kn-aut-name=上野剛 kn-aut-sei=上野 kn-aut-mei=剛 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=血清シアル化糖蛋白KL-6上昇はゲフィチニブで治療された非小細胞肺癌患者の予後不良因子である kn-title=Elevated serum level of sialylated glycoprotein KL-6 predicts a poor prognosis in patients with non-small cell lung cancer treated with gefitinib en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HujiwaraYoshirou en-aut-sei=Hujiwara en-aut-mei=Yoshirou kn-aut-name=藤原義朗 kn-aut-sei=藤原 kn-aut-mei=義朗 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120927 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺癌細胞におけるEGFRチロシンキナーゼ阻害薬の耐性はmicroRNA-7発現プラスミドのリポソームを用いた導入により克服される kn-title=Liposomal Delivery of MicroRNA-7-Expressing Plasmid Overcomes Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor-Resistance in Lung Cancer Cells en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=RaiKanmei en-aut-sei=Rai en-aut-mei=Kanmei kn-aut-name=頼冠名 kn-aut-sei=頼 kn-aut-mei=冠名 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺癌に対するラジオ波焼灼療法が呼吸機能に及ぼす影響 kn-title=Influence of Radiofrequency Ablation of Lung Cancer on Pulmonary Function en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TadaAkihiro en-aut-sei=Tada en-aut-mei=Akihiro kn-aut-name=多田明博 kn-aut-sei=多田 kn-aut-mei=明博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=3 article-no= start-page=375 end-page=381 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=19920620 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=2D-Time of Flight MR Angiography in Intrathoracic Masses kn-title=胸部腫瘤性病変における2D-Time of Flight MR Angiography en-subtitle= kn-subtitle= en-abstract=MR Angiography of the thorax was performed in 5 healthy volunteers and 15 patients with intrathoracic masses. 2D-MRA was obtained sequentially by means of a fast low angle shot(FLASH)technique(TR=20msec.TE=8msec, Flip angle=30within a 6-second period of breath holding. MRA for great vessels was successfully completed in all volunteers and all patients. The relation between tumor and vasculature can be visualized so definitely that MRA may be thought to be a promising complement to MR imaging in the evaluation of intrathoracic masses. kn-abstract=正常ボランティア5例, 胸部腫瘤性病変の患者15例に対してMR Angiographyを施行した.MRAは, 6秒の息、止めでFLASH法(TR=20msec, TE=8msec, Flip angle=30°)を用いて撮像した像から作成した.全ての症例で胸部大動脈, 上大静脈, 下大静脈, 肺動脈及び肺静脈根部など太い血管の明瞭なMRA像が得られ, 腫瘤とそれら大血管系との関係が把握しやすく胸部腫瘤性病変の評価に有用と考えられた. en-copyright= kn-copyright= en-aut-name=MitaniMasahiko en-aut-sei=Mitani en-aut-mei=Masahiko kn-aut-name=三谷政彦 kn-aut-sei=三谷 kn-aut-mei=政彦 aut-affil-num=1 ORCID= en-aut-name=TogamiIzumi en-aut-sei=Togami en-aut-mei=Izumi kn-aut-name=戸上泉 kn-aut-sei=戸上 kn-aut-mei=泉 aut-affil-num=2 ORCID= en-aut-name=KitagawaTakahiro en-aut-sei=Kitagawa en-aut-mei=Takahiro kn-aut-name=北川尚広 kn-aut-sei=北川 kn-aut-mei=尚広 aut-affil-num=3 ORCID= en-aut-name=KatohKatsuya en-aut-sei=Katoh en-aut-mei=Katsuya kn-aut-name=加藤勝也 kn-aut-sei=加藤 kn-aut-mei=勝也 aut-affil-num=4 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name=金澤右 kn-aut-sei=金澤 kn-aut-mei=右 aut-affil-num=5 ORCID= en-aut-name=JojaIkuo en-aut-sei=Joja en-aut-mei=Ikuo kn-aut-name=上都郁夫 kn-aut-sei=上都 kn-aut-mei=郁夫 aut-affil-num=6 ORCID= en-aut-name=HirakiYoshio en-aut-sei=Hiraki en-aut-mei=Yoshio kn-aut-name=平木祥夫 kn-aut-sei=平木 kn-aut-mei=祥夫 aut-affil-num=7 ORCID= en-aut-name=AndoAkio en-aut-sei=Ando en-aut-mei=Akio kn-aut-name=安藤陽夫 kn-aut-sei=安藤 kn-aut-mei=陽夫 aut-affil-num=8 ORCID= en-aut-name=ShimizuNobuyoshi en-aut-sei=Shimizu en-aut-mei=Nobuyoshi kn-aut-name=清水信義 kn-aut-sei=清水 kn-aut-mei=信義 aut-affil-num=9 ORCID= en-aut-name=TeramotoShigeru en-aut-sei=Teramoto en-aut-mei=Shigeru kn-aut-name=寺本滋 kn-aut-sei=寺本 kn-aut-mei=滋 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=岡山大学 affil-num=6 en-affil= kn-affil=岡山大学 affil-num=7 en-affil= kn-affil=岡山大学 affil-num=8 en-affil= kn-affil=岡山大学 affil-num=9 en-affil= kn-affil=岡山大学 affil-num=10 en-affil= kn-affil=岡山大学 en-keyword=MRA kn-keyword=MRA en-keyword=2D-Time of Flight method kn-keyword=2D-Time of Flight method en-keyword=Intrathoracic masses kn-keyword=Intrathoracic masses en-keyword=Lung cancer kn-keyword=Lung cancer END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ペメトレキセド耐性肺非小細胞癌細胞株の樹立 kn-title=Establishment of pemetrexed-resistant non-small cell lung cancer cell lines en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=張丹 kn-aut-sei=張 kn-aut-mei=丹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=テムシロリムスによるｍTOR阻害が非小細胞肺癌の胸膜播種担癌マウスの生存延長効果をもたらす kn-title=Inhibition of mTOR by temsirolimus contributes to prolonged survival of mice with pleural dissemination of non-small-cell lung cancer cells en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OharaToshiaki en-aut-sei=Ohara en-aut-mei=Toshiaki kn-aut-name=大原利章 kn-aut-sei=大原 kn-aut-mei=利章 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20101231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=対立遺伝子高頻度欠失領域15q23に位置する癌抑制遺伝子候補SIN3A遺伝子の非小細胞肺癌での発現低下 kn-title=Decreased expression of the SIN3A gene, a candidate tumor suppressor located at the prevalent allelic loss region 15q23 in non-small cell lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SuzukiHiromitsu en-aut-sei=Suzuki en-aut-mei=Hiromitsu kn-aut-name=鈴木宏光 kn-aut-sei=鈴木 kn-aut-mei=宏光 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=日本人非小細胞肺癌患者におけるEGFRシグナル伝達路の広範囲にわたる分析 kn-title=Comprehensive analysis of EGFR signaling pathways in Japanese patients with non-small cell lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HosokawaShinobu en-aut-sei=Hosokawa en-aut-mei=Shinobu kn-aut-name=細川忍 kn-aut-sei=細川 kn-aut-mei=忍 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺癌自然退縮および再発とNY-ESO-1免疫応答 kn-title=Correlation of high and decreased NY-ESO-1 immunity to spontaneous regression and subsequent recurrence in a lung cancer patient en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IsobeMidori en-aut-sei=Isobe en-aut-mei=Midori kn-aut-name=磯辺みどり kn-aut-sei=磯辺 kn-aut-mei=みどり aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=GFR チロシンキナーゼインヒビター未使用肺癌におけるMET 遺伝子増幅またはEGFR 変異によるMET の活性化 kn-title=MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KuboTakafumi en-aut-sei=Kubo en-aut-mei=Takafumi kn-aut-name=久保孝文 kn-aut-sei=久保 kn-aut-mei=孝文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20091231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=EGFR遺伝子変異やゲフィチ二ブ治療をすべき非小細胞肺癌患者を予測する因子としての喫煙量の有用性 kn-title=Usefulness of cumulative smoking dose for identifying the EGFR mutation and patients with non-small?cell lung cancer for gefitinib treatment en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=JidaMasaru en-aut-sei=Jida en-aut-mei=Masaru kn-aut-name=治田賢 kn-aut-sei=治田 kn-aut-mei=賢 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=局所進展型非小細胞肺癌におけるシスプラチンベースの放射線化学療法治療後の生存期間にHER2遺伝子および蛋白発現レベルが及ぼす影響の検討 kn-title=Impact of HER2 Gene and Protein Status on the Treatment Outcome of Cisplatin-Based Chemoradiotherapy for Locally Advanced Non-small Cell Lung Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KuyamaSyoichi en-aut-sei=Kuyama en-aut-mei=Syoichi kn-aut-name=久山彰一 kn-aut-sei=久山 kn-aut-mei=彰一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ゲフィチニブに長期間暴露したヒト非小細胞肺癌株における上皮成長因子受容体（EGFR）遺伝子のT790M変異の出現 kn-title=Emergence of Epidermal Growth Factor Receptor T790M Mutation during Chronic Exposure to Gefitinib in a Non-Small Cell Lung Cancer Cell Line en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OginoAtsuko en-aut-sei=Ogino en-aut-mei=Atsuko kn-aut-name=荻野敦子 kn-aut-sei=荻野 kn-aut-mei=敦子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ヒト小細胞肺癌細胞においてSTI571投与はurokinase-type plasminogen activator、interleukin-8 及びearly growth response-1を誘導する kn-title=Induction of urokinase-type plasminogen activator, interleukin-8 and early growth response-1 by STI571 through activating mitogen activated protein kinase in human small cell lung cancer cells en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YoshidaChikamasa en-aut-sei=Yoshida en-aut-mei=Chikamasa kn-aut-name=吉田親正 kn-aut-sei=吉田 kn-aut-mei=親正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非小細胞肺癌に対するビスフォスフォネート製剤（YM529）の抗腫瘍効果の検討 kn-title=Anti-tumor effect of bisphosphonate (YM529) on non-small cell lung cancer cell lines en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KoshimuneRyuichiro en-aut-sei=Koshimune en-aut-mei=Ryuichiro kn-aut-name=越宗龍一郎 kn-aut-sei=越宗 kn-aut-mei=龍一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ERCC1蛋白発現は非小細胞肺癌でのシスプラチンを含む術前導入化学療法の効果を予測する kn-title=ERCC1 protein expression predicts the response of cisplatin-based neoadjuvant chemotherapy in non-small-cell lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FujiiTetsuya en-aut-sei=Fujii en-aut-mei=Tetsuya kn-aut-name=藤井徹也 kn-aut-sei=藤井 kn-aut-mei=徹也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=分子的側面より検討した肺がん細胞の進展・転移モデル kn-title=Clonal and Parallel Evolution of Primary Lung Cancers and Their Metastases Revealed by Molecular Dissection of Cancer Cells en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakahashiKenji en-aut-sei=Takahashi en-aut-mei=Kenji kn-aut-name=橋健司 kn-aut-sei=橋 kn-aut-mei=健司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=変異型EGFR発現細胞株への活性化EGFR下流シグナル導入によるgefitinib耐性化 kn-title=Activation of downstream EGFR signaling provides gefitinib-resistance in cells carrying EGFR mutation en-subtitle= kn-subtitle= en-abstract= kn-abstract=Patients with pulmonary adenocarcinoma carrying the epidermal growth factor receptor (EGFR) mutation tend to display dramatic clinical response to treatment with the EGFR tyrosine kinase inhibitor gefitinib. Unfortunately, in many cases the cancer cells eventually acquire resistance, and this limits the duration of efficacy. To gain insight into these acquired resistance mechanisms, we first prepared HEK293T cell line stably transfected with either wild-type (WT) or mutant (L858R) EGFR, and then expressed oncogenic K-Ras12V mutant in the latter transfectant. Although 293T cells expressing wild-type EGFR did not show any growth inhibition by gefitinib treatment similarly to the non-transfected cells, the cells expressing the EGFR-L858R were exquisitely sensitive. Consistently, phospho-Akt levels were decreased in response to gefitinib in cells expressing EGFR-L858R but not in cells with EGFR-WT. In contrast, 293T cells expressing both EGFR-L858R and oncogenic K-Ras were able to proliferate even in the presence of high concentration of gefitinib probably by inducing Erk1/2 activation. We also expressed K-Ras12V in the gefitinib-sensitive pulmonary adenocarcinoma cell line PC-9, which harbors an in-frame deletion in the EGFR gene. The activated K-Ras inhibited the effects of gefitinib treatment on cell growth, cell death induction and levels of phospho-Akt, as well as phospho-Erk. These data indicate that activated Ras could substitute most of the upstream EGFR signal, and are consistent with the hypothesis that mutational activation of targets immediately downstream from the EGFR could induce the secondary resistance to gefitinib in patients with lung cancer carrying EGFR mutation. en-copyright= kn-copyright= en-aut-name=UchidaAkiko en-aut-sei=Uchida en-aut-mei=Akiko kn-aut-name=内田亜希子 kn-aut-sei=内田 kn-aut-mei=亜希子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=TYROSINE KINASE INHIBITOR kn-keyword=TYROSINE KINASE INHIBITOR en-keyword=PREVIOUSLY TREATED PATIENTS kn-keyword=PREVIOUSLY TREATED PATIENTS en-keyword=LUNG-CANCER kn-keyword=LUNG-CANCER en-keyword=INCREASES SENSITIVITY kn-keyword=INCREASES SENSITIVITY en-keyword=ACQUIRED-RESISTANCE kn-keyword=ACQUIRED-RESISTANCE en-keyword=GENE-MUTATIONS kn-keyword=GENE-MUTATIONS en-keyword=IN-VIVO kn-keyword=IN-VIVO en-keyword=ERLOTINIB kn-keyword=ERLOTINIB en-keyword=PATHWAYS kn-keyword=PATHWAYS en-keyword=IRESSA kn-keyword=IRESSA END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ゲフィチニブを投与した日本人非小細胞肺癌におけるヒト上皮成長因子受容体遺伝子異常と臨床効果の検討 kn-title=The Impact of Epidermal Growth Factor Receptor Gene Status on Gefitinib-Treated Japanese Patients with Non-Small-Cell Lung Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract=We investigated the relationships between genetic factors and clinical outcome in Japanese non-small-cell lung cancer (NSCLC) patients treated with gefitinib. Ninety-eight NSCLC patients who had been treated with gefitinib, were screened for mutations in epidermal growth factor receptor (EGFR) exons 18-21, KRAS exon2, and polymorphisms including the CA simple sequence repeat in intron1 (CA-SSR1) and single nucleotide polymorphisms in the promoter region (-216G/T and -191C/A), using a PCR-based assay and direct sequencing. The EGFR copy number status was also evaluated using a fluorescence in situ hybridization assay. EGFR and KRAS mutations were found in 38 (38.8%) and 8 (8.2%) of the 98 patients, respectively. A high EGFR copy number status was identified in 31 (41.3%) of the 75 assessable patients. Drug-sensitive EGFR mutations limited to exon19 deletions and L858R were independent predictive factors of a stronger sensitivity to gefitinib (p = 0.0002), the overall survival (OS) (p = 0.0036), and prolonged progression-free survival (PFS) (p < 0.0001). The EGFR copy number status was not related to a sensitivity to gefitinib and prolonged OS and PFS. Regarding polymorphisms, patients with a short CA-SSR1 showed a prolonged OS as compared with those with a long length in patients with a drug-sensitive EGFR mutation, although this difference was not significant (p = 0.13). Thus, drug-sensitive EGFR mutations predict a favorable clinical outcome and a high EGFR copy number may not be related to clinical benefits in gefitinib-treated Japanese patients with NSCLC. Our findings also suggest that the CA-SSR1 length may influence the clinical outcome in patients with a drug-sensitive EGFR mutation. en-copyright= kn-copyright= en-aut-name=IchiharaShuji en-aut-sei=Ichihara en-aut-mei=Shuji kn-aut-name=市原周治 kn-aut-sei=市原 kn-aut-mei=周治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=NSCLC kn-keyword=NSCLC en-keyword=EGFR kn-keyword=EGFR en-keyword=gefitinib kn-keyword=gefitinib en-keyword=mutation kn-keyword=mutation en-keyword=amplification kn-keyword=amplification en-keyword=polymorphism kn-keyword=polymorphism END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=進行肺癌における胸水中EGFR遺伝子変異検索の有用性とゲフィチニブ臨床効果予測因子の検討 kn-title=Usefulness of EGFR mutation screening in pleural fluid to predict the clinical outcome of gefitinib treated patients with lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract=The importance of epidermal growth factor receptor (EGFR) gene mutation has been recognized in nonsmall cell lung cancer (NSCLC), requiring the standardization of mutation screening system including the kind of samples. Here, we examined the EGFR mutation status in 61 pleural fluid samples from NSCLC cases using direct sequencing, nonenriched PCR, mutant-enriched PCR and peptide nucleic acid-locked nucleic acid (PNA-LNA) PCR clamp assay. The mutant-enriched PCR assay detected 16 mutant cases. Among them, the nonenriched PCR assay failed to detect 3 mutant cases. Regarding the discrepancy between mutant-enriched PCR and PNA-LNA PCR clamp assays, 3 cases of exon19-deletions were detected only by mutant-enriched PCR assay and no difference at the L858R mutation. There was no difference in results between direct sequencing and nonenriched PCR assay. We also correlated the EGFR mutation with clinical outcome of gefitinib-treated 29 cases. EGFR mutations were present in 10 cases, revealing 7 partial response and 3 no change (NC). In EGFR wild-type cases, 10 revealed NC and 9 progressive disease. The responders were significantly more frequent among the EGFR mutant cases than among the wild-type (p < 0.0001). Overall survival (p = 0.0092) and progression-free survival (p = 0.018) were significantly longer among the EGFR mutant cases than among the wild-type. In summary, we evaluated the utility of EGFR mutation screening in pleural fluid using 4 assays that showed some discrepancies arising from the designs of the assays. As clinical importance, the EGFR mutation status in pleural fluid can be a biomarker for the favorable outcome of gefitinib-treated NSCLC cases. en-copyright= kn-copyright= en-aut-name=SoJun-ichi en-aut-sei=So en-aut-mei=Jun-ichi kn-aut-name=宗淳一 kn-aut-sei=宗 kn-aut-mei=淳一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=EGFR kn-keyword=EGFR en-keyword=lung cancer kn-keyword=lung cancer en-keyword=pleural fluid kn-keyword=pleural fluid en-keyword=mutant-enriched PCR kn-keyword=mutant-enriched PCR en-keyword=gefitinib kn-keyword=gefitinib END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20061231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非小細胞肺癌におけるマイナークローンとしてのヒト上皮成長因子受容体T790M変異の意義 kn-title=Presence of Epidermal Growth Factor Receptor Gene T790M Mutation as a Minor Clone in Non-Small Cell Lung Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=InukaiMichio en-aut-sei=Inukai en-aut-mei=Michio kn-aut-name=犬飼道雄 kn-aut-sei=犬飼 kn-aut-mei=道雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非小細胞性肺癌におけるXAGE-1の発現及び肺癌患者における抗体反応 kn-title=XAGE-1 Expression in Non-Small Cell Lung Cancer and Antibody Response in Patients en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川和彦 kn-aut-sei=中川 kn-aut-mei=和彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ヒストン脱アセチル化阻害剤FR901228はヒト肺癌細胞においてテロメラーゼ特異的制限増殖アデノウイルスOBP-301の抗腫瘍効果を増強する kn-title=Histone deacetylase inhibitor FR901228 enhances the antitumor effect of telomerase-specific replication-selective adenoviral agent OBP-301 in human lung cancer cells en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeTakanori en-aut-sei=Watanabe en-aut-mei=Takanori kn-aut-name=渡邉貴紀 kn-aut-sei=渡邉 kn-aut-mei=貴紀 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺癌検診における近年の成績向上：異なる2つの時期における検診結果の比較から kn-title=Recent Improvement in Lung Cancer Screening: A Comparison of the Results Carried Out in Two Different Time Periods en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KitajimaTakuji en-aut-sei=Kitajima en-aut-mei=Takuji kn-aut-name=喜多嶋拓士 kn-aut-sei=喜多嶋 kn-aut-mei=拓士 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Mutant-enriched PCR法による肺癌のEGFR遺伝子変異の検出 kn-title=Detection of EGFR Gene Mutation in Lung Cancer by Mutant-enriched PCR Assay en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AsanoHiroaki en-aut-sei=Asano en-aut-mei=Hiroaki kn-aut-name=浅野博昭 kn-aut-sei=浅野 kn-aut-mei=博昭 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非小細胞肺癌におけるEGFR遺伝子変異と臨床病理学的因子の関係 kn-title=The Relationship between Epidermal Growth Factor Receptor Mutations and Clinicopathologic Features in Non-Small Cell Lung Cancers en-subtitle= kn-subtitle= en-abstract= kn-abstract=PURPOSE: Recent studies reported that clinical responsiveness to gefitinib was associated with somatic mutation of epidermal growth factor receptor (EGFR) gene in non-small cell lung cancers (NSCLC). Here, we investigated the relationship between EGFR mutation and clinicopathologic features. EXPERIMENTAL DESIGN: EGFR mutational status of 120 NSCLCs was determined mainly in EGFR exons 18 to 21 by direct sequence and correlated with clinicopathologic parameters. RESULTS: EGFR mutations were present in 38 cases (32%) and the majority of mutations were in-frame deletions of exon 19 (19 cases) and a missense mutation in exon 21 (18 cases). EGFR mutations were frequently associated with adenocarcinoma (P < 0.0001), never smoker (P < 0.0001), and female gender (P = 0.0001). Of interest, increasing smoke exposure was inversely related to the rate of EGFR mutation (P < 0.0001). Multivariate analysis showed that smoking and histology were independent variables. Furthermore, gender difference was observed for the mutational location (P = 0.01) dominance of exon 19 for males and exon 21 for females. Twenty-one cases were treated with gefitinib and found that EGFR mutation was significantly related to gefitinib responsiveness (P = 0.002). In addition, median survival times of patients with and without EGFR mutations treated with gefitinib were 25.1 and 14.0 months, respectively. Patients with EGFR mutations had approximately 2-fold survival advantage; however, the difference was not significant. CONCLUSIONS: We show that EGFR mutations were significantly related to histology and smoke exposure and were a strong predictive factor for gefitinib responsiveness in NSCLC. en-copyright= kn-copyright= en-aut-name=TokumoMasaki en-aut-sei=Tokumo en-aut-mei=Masaki kn-aut-name=ｺ毛誠樹 kn-aut-sei=ｺ毛 kn-aut-mei=誠樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非小細胞肺癌組織に腫瘍特異的に認められたHells/SMARCA6遺伝子のスプライシング異常に関する研究 kn-title=TUMOR-SPECIFIC EXON CREATION OF THE HELLS/SMARCA6 GENE IN NON-SMALL CELL LUNG CANCERS en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YanoMasaaki en-aut-sei=Yano en-aut-mei=Masaaki kn-aut-name=矢野匡亮 kn-aut-sei=矢野 kn-aut-mei=匡亮 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=進行非小細胞肺癌患者におけるドセタキセル及びイリノテカン併用療法の臨床第I相試験 kn-title=Phase I study of docetaxel and irinotecan in patients with advanced non-small-cell lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NogamiNaoyuki en-aut-sei=Nogami en-aut-mei=Naoyuki kn-aut-name=野上尚之 kn-aut-sei=野上 kn-aut-mei=尚之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=進行非小細胞肺癌症例に対するイリノテカンとパクリタキセルの薬物動態解析を伴う第I相試験 kn-title=A phase I study and pharmacokinetics of irinotecan (CPT-11) and paclitaxel in patients with advanced non-small cell lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HottaKatsuyuki en-aut-sei=Hotta en-aut-mei=Katsuyuki kn-aut-name=堀田勝幸 kn-aut-sei=堀田 kn-aut-mei=勝幸 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非小細胞肺癌におけるEGFR,リン酸化Akt,そしてHIF-1αの相互関係 kn-title=Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1α in non-small cell lung cancers en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HiramiYuji en-aut-sei=Hirami en-aut-mei=Yuji kn-aut-name=平見有二 kn-aut-sei=平見 kn-aut-mei=有二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=血清DNAにおけるプロモーター領域のメチル化検出は肺癌の早期発見に有用である kn-title=Identification of Epigenetic Aberrant Promoter Methylation in Serum DNA Is Useful for Early Detection of Lung Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FujiwaraKeiichi en-aut-sei=Fujiwara en-aut-mei=Keiichi kn-aut-name=藤原慶一 kn-aut-sei=藤原 kn-aut-mei=慶一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20041231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺癌,乳癌,悪性胸膜中皮腫におけるp57KIP2遺伝子のメチル化に関する研究 kn-title=Aberrant methylation of p57KIP2 gene in lung and breast cancers and malignant mesotheliomas en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KobatakeTakaya en-aut-sei=Kobatake en-aut-mei=Takaya kn-aut-name=小畠誉也 kn-aut-sei=小畠 kn-aut-mei=誉也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非小細胞肺癌におけるNY-ESO-1発現の臨床病理学的検討 kn-title=The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KonishiJuichiro en-aut-sei=Konishi en-aut-mei=Juichiro kn-aut-name=小西寿一郎 kn-aut-sei=小西 kn-aut-mei=寿一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=7-Ethyl-10-hydroxy-camptothecin耐性肺小細胞癌株の樹立 kn-title=Establishment of a 7-Ethyl-10-hydroxy-camptothecin-resistant Small Cell Lung Cancer Cell Line en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ChikamoriMasakazu en-aut-sei=Chikamori en-aut-mei=Masakazu kn-aut-name=近森正和 kn-aut-sei=近森 kn-aut-mei=正和 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支鏡検査による肺癌診断率向上の試み kn-title=Evaluation of various cytological examinations by bronchoscopy in diagnosis of peripheral lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦家正志 kn-aut-sei=瓦家 kn-aut-mei=正志 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20041231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非小細胞性肺癌における遺伝子のメチル化と臨床病理学的検討 kn-title=DNA methylation of multiple genes and clinicopathological relationship of non-small cell lung cancers en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HanabataTetsuro en-aut-sei=Hanabata en-aut-mei=Tetsuro kn-aut-name=花畑哲郎 kn-aut-sei=花畑 kn-aut-mei=哲郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=自家血清を用いた肺がん細胞cDNAライブラリーの免疫学的スクリーニング:主抗原としてのXAGE-1bの同定とその免疫原性 kn-title=IMMUNOSCREENING OF A cDNA LIBRARY FROM A LUNG CANCER CELL LINE USING AUTOLOGOUS PATIENT SERUM: IDENTIFICATION OF XAGE-1b AS A DOMINANT ANTIGEN AND ITS IMMUNOGENICITY IN LUNG ADENOCARCINOMA en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=EldibAli Mohamed Ali en-aut-sei=Eldib en-aut-mei=Ali Mohamed Ali kn-aut-name=エルディブアリ モハメド アリ kn-aut-sei=エルディブ kn-aut-mei=アリ モハメド アリ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20021231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Poor-Riskの切除不能非小細胞肺癌患者に対する低容量Cisplatin連日投与と胸部照射の同時併用療法 kn-title=Daily Low-Dose Cisplatin and Concurrent Thoracic Irradiation for Poor-Risk Patients with Unresectable Non-Small-Cell Lung Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田一郎 kn-aut-sei=田 kn-aut-mei=一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=種々の耐性機構を示すアドリアマイシン耐性ヒト肺小細胞癌株の樹立 kn-title=Establishment of an Adriamycin-Resistant Subline of Human Small Cell Lung Cancer Showing Multifactorial Mechanisms of Resistance en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KiuraKatsuyuki en-aut-sei=Kiura en-aut-mei=Katsuyuki kn-aut-name=木浦勝行 kn-aut-sei=木浦 kn-aut-mei=勝行 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=RT-PCR法による肺小細胞癌患者の末梢血中の腫瘍細胞の検出 kn-title=Detection of Occult Tumor Cells in Peripheral Blood from Patients with Small Cell Lung Cancer by Reverse Transcriptase-Polymerase Chain Reaction en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=別所昭宏 kn-aut-sei=別所 kn-aut-mei=昭宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=アポトーシス抵抗性自己肺癌細胞株に対する細胞傷害性T細胞の誘導 kn-title=Generation of cytotoxic T lymphocytes against autologous lung cancer cells resistant to apoptosis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HirakiAkio en-aut-sei=Hiraki en-aut-mei=Akio kn-aut-name=平木章夫 kn-aut-sei=平木 kn-aut-mei=章夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=びまん性間質性陰影を伴う肺癌患者の肺局所リンパ球における Interleukin-2 Receptor α mRNA 発現の検討 kn-title=Overexpression of Interleukin-2 Receptor α mRNA in Pulmonary Lymphocytes of Lung Cancer Patients Associated wth Interstitial Pulmonary Shadow en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ShinagawaKatsuji en-aut-sei=Shinagawa en-aut-mei=Katsuji kn-aut-name=品川克至 kn-aut-sei=品川 kn-aut-mei=克至 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20021231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=核蛋白質hnRNP B1にてモニタリングをおこなうエピガロカテキンガーレートによる肺癌の化学予防 kn-title=Lung cancer prevention with (-)-epigallocatechin gallate using monitoring by heterogeneous nuclear ribonucleoprotein B1 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤本伸一 kn-aut-sei=藤本 kn-aut-mei=伸一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19931231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺小細胞癌におけるMDR1遺伝子発現の検討;予後因子としてのMDR1 kn-title=MDRl Gene Expression and Treatment Outcome in Small Cell Lung Cancer ; MDR1 Gene Expression as an Independent Prognostic Factor en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田端雅弘 kn-aut-sei=田端 kn-aut-mei=雅弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=19920331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺癌化学療法における基礎的研究 第1編エトポシド耐性ヒト肺小細胞癌細胞株の樹立とその性状) 第2編新しいアンスラサイクリン系薬剤 ME2303, KRN8602, SM5887 のヒト肺癌細胞株における抗腫瘍効果の検討) kn-title=第1編 Establishment and Characterzation of an Etoposide-resistant Human Small Cell Lung Cancer Cell Line 第2編 Comparison of Antitumor Activity of New Anthracycline Analogues, ME2303, KRN8602, and SM5887 Using Human Lung Cancer Cell Lines en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=瀧川奈義夫 kn-aut-sei=瀧川 kn-aut-mei=奈義夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非小細胞肺癌におけるテロメレース活性とBcl-2蛋白の発現 kn-title=Telomerase Activity and Bcl-2 Expression in Non-Small Cell Lung Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大村泰之 kn-aut-sei=大村 kn-aut-mei=泰之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=進行非小細胞肺癌における予後因子:血清NSE値の上昇は予後不良であることを示す kn-title=Prognostic Factors in Advanced Non-small Cell Lung Cancer: Elevated Serum Levels of Neuron Specific Enolase Indicate Poor Prognosis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=前田忠士 kn-aut-sei=前田 kn-aut-mei=忠士 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=化学療法前後に樹立された肺非小細胞癌細胞株の特徴 kn-title=Characterization of non-small-cell lung cancer cell lines established before and after chemotherapy en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=川井治之 kn-aut-sei=川井 kn-aut-mei=治之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺癌細胞株におけるシスプラチンまたはビノレルビン併用時のドセタキセルの抗腫瘍効果 kn-title=Effect of Docetaxel with Cisplatin or Vinorelbine on Lung Cancer Cell Lines en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=青江啓介 kn-aut-sei=青江 kn-aut-mei=啓介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19931231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺小細胞癌における神経細胞接着因子の発現とその臨床像の関連: 金コロイドを用いた免疫組織学的方法による組織の神経細胞接着因子の半定量的検出 kn-title=Neural Cell Adhesion Molecule Expression and Clinical Features in Small Cell Lung Cancer : A Semi-Quantitative Immunohistochemical Approach Using an Immunogold-Silver Staining Method en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=畝川芳彦 kn-aut-sei=畝川 kn-aut-mei=芳彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=シスプラチン耐性ヒト肺小細胞癌細胞株はビンカアルカロイドに親株よりも高い感受性を示した kn-title=Cisplatin-Resistant Human Small Cell Lung Cancer Cell Line Shows Collateral Sensitivity to Vinca Alkaloids en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=森智典 kn-aut-sei=森 kn-aut-mei=智典 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=アドリアマイシン耐性肺小細胞癌細胞株に対する葉酸代謝拮抗剤の殺細胞効果 kn-title=Growth Inhibitory Effects of Antifolates against an Adriamycin- Resistant Human Small Cell Lung Cancer Cell Line en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松尾圭祐 kn-aut-sei=松尾 kn-aut-mei=圭祐 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ヒト肺癌細胞系列を用いた薬剤感受性パネルの樹立 kn-title=Establishment of a Drug-Sensitivity Panel Using Human Lung Cancer Cell Lines en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松下昭夫 kn-aut-sei=松下 kn-aut-mei=昭夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=進行肺非小細胞癌に対するVindesine,Ifosfamide,Cisplatin併用療法とVindesine,Cisplatin併用療法の第V相無作為化比較試験:長期追跡結果と予後因子解析に関しての検討 kn-title=A Phase V Randomized Trial Comparing Vindesine and Cisplatin with or without Ifosfamide in Patients with Advanced Non-Small-Cell Lung Cancer: Long-Term Follow-up Results and Analysis of Prognostic Factors en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小谷剛士 kn-aut-sei=小谷 kn-aut-mei=剛士 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=シスプラチン耐性ヒト小細胞肺癌細胞株におけるトポイソメラーゼI阻害剤,7-エチル-10-ヒドロキシカンプトテシンと放射線の相乗効果の検討 kn-title=Synergistic effects of topoisomerase I inhibitor, 7-ethyl-10-hydroxycamptothecin, and irradiation in a cisplatin-resistant human small-cell lung cancer cell line en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小原弘之 kn-aut-sei=小原 kn-aut-mei=弘之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=p16で誘導されるアポトーシスにcaspase-3によるRbのcleavageが関与する kn-title=Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KatsudaKoh en-aut-sei=Katsuda en-aut-mei=Koh kn-aut-name=勝田浩 kn-aut-sei=勝田 kn-aut-mei=浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺小細胞癌におけるCD34 抗原発現の検討 kn-title=Small Cell Lung Cancer can Express CD34 Antigen en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山根弘路 kn-aut-sei=山根 kn-aut-mei=弘路 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19931231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=びまん性肺疾患におけるHTLV-Iの関与に関する研究 第1編新規合成プライマーを用いたポリメラーゼ連鎖反応によるHTLV-I pX遺伝子の検出) 第2編びまん性間質性胸部陰影を伴う呼吸器疾患と肺癌におけるヒトTリンパ球好性ウイルスI型のpX遺伝子の検出) kn-title=1. Detection of HTLV-I pX Gene by Polymerase Chain Reaction Using Newly Designed Primers 2. Detection of the pX Gene of Human T-Lymphotropic Virus Type I in Respiratory Diseases with Diffuse Interstitial Pulmonary Shadows and Lung Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=今城健二 kn-aut-sei=今城 kn-aut-mei=健二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺癌細胞株におけるHLA-A2結合性MAGE-3ペプチド発現の検討 kn-title=Variable expression on lung cancer cell lines of HLA-A'2-binding MAGE-3 peptide recognized by cytotoxic T lymphocytes en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高木敏行 kn-aut-sei=高木 kn-aut-mei=敏行 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺小細胞癌における変異p53蛋白の免疫組織学的検討:治療成績との関連性について kn-title=Immunohistochemical detection of mutant p53 protein in small-cell lung cancer: relationship to treatment outcome en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=玄馬顕一 kn-aut-sei=玄馬 kn-aut-mei=顕一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺小細胞癌における抗癌剤耐性に関する研究 第1編 アドリアマイシン耐性ヒト肺小細胞癌細胞株の樹立とその性状) 第2編 アドリアマイシン耐性ヒト肺小細胞癌細胞株の in vitro における交叉耐性の検討) kn-title=第1編 Establishment and characterization of an adriamycin-resistant subline of human small cell lung cancer cells 第2編 In vitro chemosensitivity and radiosensitivity of an adriamycin resistant subline of human small cell lung cancer cells en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=宮本宏明 kn-aut-sei=宮本 kn-aut-mei=宏明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=切除不能肺非小細胞癌患者における変異p53蛋白､P糖蛋白､Glutathione S-transferase-πの予後因子としての有用性の検討 kn-title=Prognostic Significance of Mutant p53 Protein, P-glycoprotein and Glutathione S-transferase-π in Patients with Unresectable Non-small Cell Lung Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MiyatakeKazuyo en-aut-sei=Miyatake en-aut-mei=Kazuyo kn-aut-name=宮武和代 kn-aut-sei=宮武 kn-aut-mei=和代 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=19940630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Chemothrapy of small cell lung cancer : Comparative phase U study of CAV-PVP hybrid regimen and CAV-PVP sequential regimen in patients with small cell lung cancer(SCLC) kn-title=肺小細胞癌の化学療法に関する研究―肺小細胞癌に対する CAV-PVP hybrid 療法と CAV-PVP sequential 療法の無作為化比較試験― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KameiHaruhito en-aut-sei=Kamei en-aut-mei=Haruhito kn-aut-name=亀井治人 kn-aut-sei=亀井 kn-aut-mei=治人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非小細胞肺癌肺内転移の予後的検討 kn-title=Intrapulmonary metastasis of non-small cell lung cancer. A prognostic assessment en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=奥村武弘 kn-aut-sei=奥村 kn-aut-mei=武弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ヒト肺小細胞癌の細胞株に対する微小管阻害剤の効果の検討 kn-title=In Vitro Evaluation of Antimicrotubule Agents in Human Small-Cell Lung Cancer Cell Lines en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=井久保卯 kn-aut-sei=井久保 kn-aut-mei=卯 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=p53野生型およびp53変異型非小細胞肺癌細胞株におけるIFN-α/TNF-αによるアポトーシス誘導効果とc-myc発現に関する検討 kn-title=Combination of Tumor Necrosis Factor Alpha and Interferon Alpha Induces Apoptotic Cell Death through a c-myc-Dependent Pathway in p53 Mutant H226br Non-Small-Cell Lung Cancer Cell Line en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YasuokaYasuo en-aut-sei=Yasuoka en-aut-mei=Yasuo kn-aut-name=安岡康夫 kn-aut-sei=安岡 kn-aut-mei=康夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Tumor Necrosis Factor Alpha kn-keyword=Tumor Necrosis Factor Alpha en-keyword=Interferon Alpha kn-keyword=Interferon Alpha en-keyword=p53 Mutant H226br Non-Small-Cell Lung Cancer Cell Line kn-keyword=p53 Mutant H226br Non-Small-Cell Lung Cancer Cell Line END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Non-small cell lung cancerにおけるp53の細胞増殖と化学放射感受性(chemoradio- sensitivity)に及ぼす生体内での影響) kn-title=In vivo influence of p53 status on proliferation and chemoradio- sensitivity in non-small cell lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Jose' AntonioPerdomo kn-aut-sei=Jose' Antonio kn-aut-mei=Perdomo aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END