start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=241001 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Metamorphic pressure-temperature conditions of garnet granulite from the Eastern Iratsu body in the Sambagawa belt, SW Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=Several coarse-grained mafic bodies with evidence for eclogite-facies metamorphism are present in the Besshi area of the Sambagawa subduction-type metamorphic belt, SW Japan. Among them the granulite-bearing Eastern Iratsu metagabbro body involves an unresolved problem of whether it originated in the hanging-wall or footwall side of the subduction zone. The key to settle this problem is its relationship with the adjacent Western Iratsu metabasaltic body, which includes thick marble layer and certainly has the footwall ocean-floor origin. Several previous studies consider that the Western and Eastern Iratsu bodies were originally coherent in the footwall side and formed the shallower and deeper parts of a thick oceanic crust, respectively. The validity of this hypothesis may be assessed by deriving pressure-temperature history of the Eastern Iratsu body, or especially the pressure (depth) condition of the granulite-facies metamorphism before the eclogite-facies overprinting because, if the pressure was relatively high, the oceanic crust assumed in the above hypothesis might be too thick to tectonically achieve the present-day adjacence of the two bodies on the geological map. This study petrologically analyzes a garnet-bearing granulite from the Eastern Iratsu body and newly reports stable coexistence of garnet and orthopyroxene in the sample. By utilizing a garnet-orthopyroxene geothermobarometer, the minimum P-T conditions of the granulite-facies stage was estimated to be 0.8 GPa (? 27 km in depth) and 780 °C. If the Western and Eastern Iratsu bodies were assumed to have formed a coherent oceanic crust before their subduction, the original thickness of it was >27 km and this demands unusually strong ductile shortening (<1/9) or unrealistically large vertical displacement on intraplate faulting, suggesting invalidity of the assumption. The Western and Eastern Iratsu bodies, therefore, are originally bounded by subduction-boundary fault and the obtained pressure of 0.8 GPa can be interpreted to represent that of the hanging-wall lower continental crust in the subduction zone, where the Eastern Iratsu body originated. After the granulite-facies metamorphism, the Western Iratsu body, which was located near the footwall surface, initiated subduction and was subsequently juxtaposed with the above-located Eastern Iratsu body at the corresponding depth (? 27 km or greater) along the subduction boundary. en-copyright= kn-copyright= en-aut-name=NAKAMURADaisuke en-aut-sei=NAKAMURA en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AOYAMutsuki en-aut-sei=AOYA en-aut-mei=Mutsuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OKAMURATomoki en-aut-sei=OKAMURA en-aut-mei=Tomoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Technology, Industrial and Social Sciences, Tokushima University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=Sambagawa belt kn-keyword=Sambagawa belt en-keyword=Iratsu body kn-keyword=Iratsu body en-keyword=Metagabbro kn-keyword=Metagabbro en-keyword=Granulite kn-keyword=Granulite en-keyword=Hanging wall kn-keyword=Hanging wall END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=一細胞解析を応用した軟骨細胞分化を制御する転写因子の遡及的な再発見法　 kn-title=Retrospective re-discovery of the transcription factor that controls chondrocyte differentiation by single cell RNA-sequencing en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=DO Thuy Hang en-aut-sei=DO Thuy Hang en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=4 article-no= start-page=373 end-page=383 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Central and Enteric Neuroprotective Effects by Eucommia ulmoides Extracts on Neurodegeneration in Rotenone-induced Parkinsonian Mouse en-subtitle= kn-subtitle= en-abstract= kn-abstract=Parkinson’s disease (PD) is a progressive neurodegenerative disease of both the central and peripheral / enteric nervous systems. Oxidative stress and neuroinflammation are associated with the pathogenesis of PD, suggesting that anti-oxidative and anti-inflammatory compounds could be neuroprotective agents for PD. Eucommia ulmoides (EU) is a traditional herbal medicine which exerts neuroprotective effects by anti-inflammatory and anti-oxidative properties. Our previous study showed that treatment with chlorogenic acid, a component of EU, protected against neurodegeneration in the central and enteric nervous systems in a PD model. In this study, we examined the effects of EU extract (EUE) administration on dopaminergic neurodegeneration, glial response and α-synuclein expression in the substantia nigra pars compacta (SNpc), and intestinal enteric neurodegeneration in low-dose rotenone-induced PD model mice. Daily oral administration of EUE ameliorated dopaminergic neurodegeneration and α-synuclein accumulation in the SNpc. EUE treatment inhibited rotenone- induced decreases in the number of total astrocytes and in those expressing the antioxidant molecule metallothionein. EUE also prevented rotenone-induced microglial activation. Furthermore, EUE treatment exerted protective effects against intestinal neuronal loss in the PD model. These results suggest that EU exerts neuroprotective effects in the central and enteric nervous systems of rotenone-induced parkinsonism mice, in part by glial modification. en-copyright= kn-copyright= en-aut-name=ImafukuFuminori en-aut-sei=Imafuku en-aut-mei=Fuminori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyazakiIkuko en-aut-sei=Miyazaki en-aut-mei=Ikuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SunJin en-aut-sei=Sun en-aut-mei=Jin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KamimaiSunao en-aut-sei=Kamimai en-aut-mei=Sunao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ShimizuTakashi en-aut-sei=Shimizu en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ToyotaToshiaki en-aut-sei=Toyota en-aut-mei=Toshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkamotoYusei en-aut-sei=Okamoto en-aut-mei=Yusei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IsookaNami en-aut-sei=Isooka en-aut-mei=Nami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KikuokaRyo en-aut-sei=Kikuoka en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KitamuraYoshihisa en-aut-sei=Kitamura en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AsanumaMasato en-aut-sei=Asanuma en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Medical Neurobiology, Okayama University Medical School kn-affil= affil-num=5 en-affil=Department of Medical Neurobiology, Okayama University Medical School kn-affil= affil-num=6 en-affil=Department of Medical Neurobiology, Okayama University Medical School kn-affil= affil-num=7 en-affil=Department of Medical Neurobiology, Okayama University Medical School kn-affil= affil-num=8 en-affil=Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Pharmacy, Okayama University Hospital kn-affil= affil-num=11 en-affil=Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Eucommia ulmoides kn-keyword=Eucommia ulmoides en-keyword=dopamine neuron kn-keyword=dopamine neuron en-keyword=enteric neuron kn-keyword=enteric neuron en-keyword=glia kn-keyword=glia en-keyword=Parkinson’s disease kn-keyword=Parkinson’s disease END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue=1 article-no= start-page=208 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Tryptophan and Kynurenine Enhances the Stemness and Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro and In Vivo en-subtitle= kn-subtitle= en-abstract= kn-abstract=Aging tissues present a progressive decline in homeostasis and regenerative capacities, which has been associated with degenerative changes in tissue-specific stem cells and stem cell niches. We hypothesized that amino acids could regulate the stem cell phenotype and differentiation ability of human bone marrow-derived mesenchymal stromal cells (hBMSCs). Thus, we performed a screening of 22 standard amino acids and found that D-tryptophan (10 mu M) increased the number of cells positive for the early stem cell marker SSEA-4, and the gene expression levels of OCT-4, NANOG, and SOX-2 in hBMSCs. Comparison between D- and L-tryptophan isomers showed that the latter presents a stronger effect in inducing the mRNA levels of Oct-4 and Nanog, and in increasing the osteogenic differentiation of hBMSCs. On the other hand, L-tryptophan suppressed adipogenesis. The migration and colony-forming ability of hBMSCs were also enhanced by L-tryptophan treatment. In vivo experiments delivering L-tryptophan (50 mg/kg/day) by intraperitoneal injections for three weeks confirmed that L-tryptophan significantly increased the percentage of cells positive for SSEA-4, mRNA levels of Nanog and Oct-4, and the migration and colony-forming ability of mouse BMSCs. L-kynurenine, a major metabolite of L-tryptophan, also induced similar effects of L-tryptophan in enhancing stemness and osteogenic differentiation of BMSCs in vitro and in vivo, possibly indicating the involvement of the kynurenine pathway as the downstream signaling of L-tryptophan. Finally, since BMSCs migrate to the wound healing site to promote bone healing, surgical defects of 1 mm in diameter were created in mouse femur to evaluate bone formation after two weeks of L-tryptophan or L-kynurenine injection. Both L-tryptophan and L-kynurenine accelerated bone healing compared to the PBS-injected control group. In summary, L-tryptophan enhanced the stemness and osteoblastic differentiation of BMSCs and may be used as an essential factor to maintain the stem cell properties and accelerate bone healing and/or prevent bone loss. en-copyright= kn-copyright= en-aut-name=PhamHai Thanh en-aut-sei=Pham en-aut-mei=Hai Thanh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OnoMitsuaki en-aut-sei=Ono en-aut-mei=Mitsuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HaraEmilio Satoshi en-aut-sei=Hara en-aut-mei=Emilio Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NguyenHa Thi Thu en-aut-sei=Nguyen en-aut-mei=Ha Thi Thu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=DangAnh Tuan en-aut-sei=Dang en-aut-mei=Anh Tuan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=DoHang Thuy en-aut-sei=Do en-aut-mei=Hang Thuy kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KomoriTaishi en-aut-sei=Komori en-aut-mei=Taishi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TosaIkue en-aut-sei=Tosa en-aut-mei=Ikue kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=Hazehara-KunitomoYuri en-aut-sei=Hazehara-Kunitomo en-aut-mei=Yuri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YoshiokaYuya en-aut-sei=Yoshioka en-aut-mei=Yuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=OidaYasutaka en-aut-sei=Oida en-aut-mei=Yasutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=AkiyamaKentaro en-aut-sei=Akiyama en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KubokiTakuo en-aut-sei=Kuboki en-aut-mei=Takuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Biomaterials, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=13 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=amino acid kn-keyword=amino acid en-keyword=mesenchymal stromal cells kn-keyword=mesenchymal stromal cells en-keyword=stemness kn-keyword=stemness en-keyword=tryptophan kn-keyword=tryptophan en-keyword=kynurenine kn-keyword=kynurenine en-keyword=osteogenesis kn-keyword=osteogenesis en-keyword=adipogenesis kn-keyword=adipogenesis en-keyword=screening kn-keyword=screening en-keyword=injury/fracture healing kn-keyword=injury/fracture healing en-keyword=anabolics kn-keyword=anabolics END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue= article-no= start-page=251 end-page=253 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20201008 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A novel modified hanging maneuver in laparoscopic left hemihepatectomy en-subtitle= kn-subtitle= en-abstract= kn-abstract=Introduction
The liver hanging maneuver is an essential technique for controlling bleeding in hepatectomy, however it is often difficult in laparoscopic major hepatectomy. The present study describes a novel modified hanging maneuver in laparoscopic left hemihepatectomy.
Presentation of case
A 29-year-old female underwent laparoscopic left hemihepatectomy for mucinous cystic neoplasm. After mobilizing the left lobe, the liver parenchyma was dissected along the demarcation line. For the hanging technique, the upper edge of the hanging tape was placed on the lateral side of the left hepatic vein, and fixed with the Falciform ligament. The lower edge of the tape was extracted outside the abdomen. Accordingly the hanging tape can be controlled extraperitoneally during the liver parenchyma dissection.
Discussion
This technique includes several advantages including no need of assistance using forceps, easy control of the hanging tape extraperitoneally, outflow control, better exposure of surgical field, and helpful guide of the liver dissection line toward the root of the left hepatic vein. Conclusion
Our novel modified hanging maneuver is easy and reproducible to use in laparoscopic left hemihepatectomy. Moreover, this technique can be applied to other laparoscopic hepatectomy. en-copyright= kn-copyright= en-aut-name=TakagiKosei en-aut-sei=Takagi en-aut-mei=Kosei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UmedaYuzo en-aut-sei=Umeda en-aut-mei=Yuzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KuiseTakashi en-aut-sei=Kuise en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YoshidaRyuichi en-aut-sei=Yoshida en-aut-mei=Ryuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YoshidaKazuhiro en-aut-sei=Yoshida en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YasuiKazuya en-aut-sei=Yasui en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TaniYuma en-aut-sei=Tani en-aut-mei=Yuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YagiTakahito en-aut-sei=Yagi en-aut-mei=Takahito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=Hanging maneuver kn-keyword=Hanging maneuver en-keyword=Laparoscopic kn-keyword=Laparoscopic en-keyword=Liver resection kn-keyword=Liver resection END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue=1 article-no= start-page=17102 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20201013 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron loss. Muse cells are endogenous reparative pluripotent-like stem cells distributed in various tissues. They can selectively home to damaged sites after intravenous injection by sensing sphingosine-1-phosphate produced by damaged cells, then exert pleiotropic effects, including tissue protection and spontaneous differentiation into tissue-constituent cells. In G93A-transgenic ALS mice, intravenous injection of 5.0x10(4) cells revealed successful homing of human-Muse cells to the lumbar spinal cords, mainly at the pia-mater and underneath white matter, and exhibited glia-like morphology and GFAP expression. In contrast, such homing or differentiation were not recognized in human mesenchymal stem cells but were instead distributed mainly in the lung. Relative to the vehicle groups, the Muse group significantly improved scores in the rotarod, hanging-wire and muscle strength of lower limbs, recovered the number of motor neurons, and alleviated denervation and myofiber atrophy in lower limb muscles. These results suggest that Muse cells homed in a lesion site-dependent manner and protected the spinal cord against motor neuron death. Muse cells might also be a promising cell source for the treatment of ALS patients. en-copyright= kn-copyright= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KushidaYoshihiro en-aut-sei=Kushida en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WakaoShohei en-aut-sei=Wakao en-aut-mei=Shohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NomuraEmi en-aut-sei=Nomura en-aut-mei=Emi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OmoteYoshio en-aut-sei=Omote en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=DezawaMari en-aut-sei=Dezawa en-aut-mei=Mari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine kn-affil= affil-num=3 en-affil=Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine kn-affil= affil-num=4 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine kn-affil= affil-num=11 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Mesenchymal stem cells kn-keyword=Mesenchymal stem cells en-keyword=Neurological disorders kn-keyword=Neurological disorders END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=2 article-no= start-page=87 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=2020 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Propagation and Floral Induction of Transplant for Forcing Long-term Production of Seasonal Flowering Strawberries in Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=In Japan, over 95% of the acreage is covered with plastic to force June-bearing (seasonal flowering, SF) strawberry cultivars to produce fruit from late fall to early summer. During the late 1960s, a forcing technique was developed that advanced flower bud initiation to late summer and prevented the transplants from becoming dormant during winter. This new forcing technique involved nitrogen starvation of nursery plants to induce floral initiation. Until about 1980, strawberry growers in Japan used runner plants produced in waiting beds, but most transplants are now produced in plastic pots under rain shelters to avoid soil-borne diseases. Recently, the use of tray plants produced from hanging runner cuttings has become popular. To induce early floral initiation, the following artificial low temperature (LT) treatments have been established: (1) “Yarei”, a combination of a short day with solar radiation and LT under darkness in cooling facilities (Yarei-ko); (2) “Kaburei”, continuous dark-LT with refrigeration facilities including industrial warehouses; and (3) “Kanketsu-reizo”, intermittent LT storage. An overview of the technologies applied to plant propagation and the control of floral initiation of Japanese SF cultivars is provided in this review. en-copyright= kn-copyright= en-aut-name=YoshidaYuichi en-aut-sei=Yoshida en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishimotoToshi en-aut-sei=Nishimoto en-aut-mei=Toshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Nara Prefecture Agricultural Research and Development Center kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=進化的計算手法を用いた流出モデルの同定とルールカーブの最適化に基づく現在および将来の気候条件下における貯水池管理の改良 kn-title=Reservoir Management Improvement under Current and Future Climate Conditions Based on Evolutionary Computation Technique Application for Calibrating Hydrological Model and Optimizing Rule Curves en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Nguyen Thi Thuy Hang kn-aut-sei=Nguyen Thi Thuy Hang kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil=岡山大学大学院環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=5 article-no= start-page=389 end-page=392 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Case of 24-week Fetus Delivered from Mother on Life Support with Brain-death from Suicide Attempt: Ethical Issues Associated with Severe Complications en-subtitle= kn-subtitle= en-abstract= kn-abstract=Advances in critical care medicine have made it possible to sustain vital organ systems in brain-dead patients. One clinical scenario besides donor organ retrieval in which a benefit may be gained from continuing life support is pregnancy. A pregnant woman in her late 30?s at 23 weeks gestation exhibiting worsening depression was referred to the Department of Psychiatry. One day after admission she attempted suicide by hanging and suffered a cardiopulmonary arrest. A fetal heart beat and fetal motion was confirmed immediately after resuscitation. Three days after admission, an emergency Cesarean section (CS) was performed because of her unstable hemodynamic situation. The baby was born and the mother died after delivery. The baby presented neurological complications. Such a case should be managed collaboratively among professional experts in several medical teams. Consensus and recommendations for the management of similar scenarios may also be adjusted. en-copyright= kn-copyright= en-aut-name=NishimuraTakeshi en-aut-sei=Nishimura en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KohamaKeisuke en-aut-sei=Kohama en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OsakoTakaaki en-aut-sei=Osako en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamadaTaihei en-aut-sei=Yamada en-aut-mei=Taihei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanakaHiroyuki en-aut-sei=Tanaka en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakaoAtsunori en-aut-sei=Nakao en-aut-mei=Atsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KotaniJoji en-aut-sei=Kotani en-aut-mei=Joji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Emergency, Disaster and Critical Care Medicine, Hyogo College of Medicine kn-affil= affil-num=2 en-affil=Senri Critical Care Medical Center kn-affil= affil-num=3 en-affil=Department of Emergency, Disaster and Critical Care Medicine, Hyogo College of Medicine kn-affil= affil-num=4 en-affil=Department of Emergency, Disaster and Critical Care Medicine, Hyogo College of Medicine kn-affil= affil-num=5 en-affil=Department of Obstetrics and Gynecology, Hyogo College of Medicine kn-affil= affil-num=6 en-affil=Department of Emergency, Disaster and Critical Care Medicine, Hyogo College of Medicine kn-affil= affil-num=7 en-affil=Department of Emergency, Disaster and Critical Care Medicine, Hyogo College of Medicine kn-affil= en-keyword=brain-dead mother kn-keyword=brain-dead mother en-keyword=suicide kn-keyword=suicide en-keyword=somatic support kn-keyword=somatic support END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=5 article-no= start-page=1034 end-page=1052 dt-received= dt-revised= dt-accepted= dt-pub-year=1929 dt-pub=19290531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?eber die Beziehung zwischen Hormon und Vitamin Experimentelle Studien ?ber den Einfluss des Insulin auf Vitamin-B-mangel im Lichte der aktiven immunisatorischen Agglutininbildung bei Kaninchen (I. Mitteilung) kn-title=免疫凝集素産生ヲ指標トセル「ヴイタミン」缺乏症ニ對スル内分泌臟器製劑ノ影響ニ關スル實驗的研究 第1報 家兎「ヴイタミン」B缺乏症ニ對スル「インスリン」注射ノ影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Es ergab sich folgendes: 1) Bei den Vitamin-B-mangel-Tieren wird durch die Verleibung des Insulins den weit gr?sseren Agglutinintiter ausgel?st als bei Kontrolltieren, 2) W?hrend bei gesunden Tieren wirkt es hemmend auf die Agglutininbildung. Dies Resultat will uns sagen, dass das Insulin eine spezisch ffi?rdernde Wirkung der Agglutininbildung bei Vitamin-B-mangel-Tieren aus?bt, und woraus k?nnte man sagendass das Hormon und Vitamin, speziell Insulin und Vitamin, einen engen Zusammen, hang bez?glich in ihren biologischen Eigenschaften haben. en-copyright= kn-copyright= en-aut-name=SuguroManabu en-aut-sei=Suguro en-aut-mei=Manabu kn-aut-name=勝呂學 kn-aut-sei=勝呂 kn-aut-mei=學 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=1 article-no= start-page=13 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of vandetanib on lung adenocarcinoma cells harboring epidermal growth factor receptor T790M mutation in vivo kn-title=生体内におけるEGFR T790M遺伝子変異を持つ肺腺癌細胞に対するバンデタニブの効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IchiharaEiki en-aut-sei=Ichihara en-aut-mei=Eiki kn-aut-name=市原英基 kn-aut-sei=市原 kn-aut-mei=英基 aut-affil-num=1 ORCID= en-aut-name=OhashiKadoaki en-aut-sei=Ohashi en-aut-mei=Kadoaki kn-aut-name=大橋圭明 kn-aut-sei=大橋 kn-aut-mei=圭明 aut-affil-num=2 ORCID= en-aut-name=TakigawaNagio en-aut-sei=Takigawa en-aut-mei=Nagio kn-aut-name=瀧川奈義夫 kn-aut-sei=瀧川 kn-aut-mei=奈義夫 aut-affil-num=3 ORCID= en-aut-name=OsawaMasahiro en-aut-sei=Osawa en-aut-mei=Masahiro kn-aut-name=大澤昌宏 kn-aut-sei=大澤 kn-aut-mei=昌宏 aut-affil-num=4 ORCID= en-aut-name=OginoAtsuko en-aut-sei=Ogino en-aut-mei=Atsuko kn-aut-name=荻野敦子 kn-aut-sei=荻野 kn-aut-mei=敦子 aut-affil-num=5 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name=谷本光音 kn-aut-sei=谷本 kn-aut-mei=光音 aut-affil-num=6 ORCID= en-aut-name=KiuraKatsuyuki en-aut-sei=Kiura en-aut-mei=Katsuyuki kn-aut-name=木浦勝行 kn-aut-sei=木浦 kn-aut-mei=勝行 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学 en-keyword=バンデタニブ kn-keyword=バンデタニブ en-keyword=VEGFR kn-keyword=VEGFR en-keyword=EGFR kn-keyword=EGFR en-keyword=T790M遺伝子変異 kn-keyword=T790M遺伝子変異 en-keyword=肺腺癌 kn-keyword=肺腺癌 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=7-2 article-no= start-page=4205 end-page=4221 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590710 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Mercury Poisoning Part 3. Study on the excretion of radioactive isotope Hg(203) Cl(2) and the effect of Ca-EDTA administration kn-title=水銀中毒に関する研究 第3編 放射性同位元素Hg(203) Cl(2)の排泄並びにCa-EDTA投与の影響に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=After administering radio-isotope Hg(203) Cl(2) into guinea pigs the author estimated the quantity of radio-isotope mercury excreted inthe urine and feces. At the same time the author studied the effect of Ca-EDTA administration on the excretion of Hg(203) Cl(2) and also the mercury distribution in the principal organs of the aminals, and arrived at the following conclusions. 1. During the period one to four days after the Hg(203) Cl(2)-adminstration the quantity of mercury excreted in the urine increases markedly, and thereafter it tends to decrease rather abruptly. On the other hang, the amount of mercury excreted in feces is greatest during the period from the third to fifth day after the administration, and it tends to decrease somewhat slowly thereafter. The amount of mercury rexcreted in the urine is as much as twice or 2.7 times that excreted in the feces. 2. One week after the administration of Hg(203) Cl(2) a considerably large amount fo it is still adsorbed in the kidneys, but it is detected only in a small amount in the organs such as the liver and caecum, and likewise the quantity detected in other organs is extremely small. 3. The administration of Ca-EDTA tends to increase markedly the amount of Hg(203) Cl(2) excreted in the urine. 4. However, no markedly increasing effect of the Ca-EDTA administration can be recognized on the excretion of Hg(203) Cl(2) in the feces. 5. The amount of Hg(203) Cl(2) adsorbed in the principal organs tends to decrease slightly in the kidneys and liver after the adminstration of Ca-EDTA. en-copyright= kn-copyright= en-aut-name=KobayashiKyozo en-aut-sei=Kobayashi en-aut-mei=Kyozo kn-aut-name=小林喬三 kn-aut-sei=小林 kn-aut-mei=喬三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=11-12 article-no= start-page=1323 end-page=1332 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199012 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the treatment for intractable asthma Part 2. Evaluation of the pharmacological action of various Kampo Medicines on lymphocyte and neutrophil functions in intractable asthmatics kn-title=難治性喘息の治療に関する研究 第2編 重症難治性喘息におけるリンパ球および好中球に及ぼす各種漢方薬の薬理作用に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The pharmacological action of Sho-saiko-to and Hange-koboku-to, components of Saiboku-to, as well as that of Sho-seiryu-to were compared with that of Saiboku-to and examined in intractable asthmatics with respect to both lymphocyte functions, including interleukin 2 (IL-2) production and IL-2 receptor expression in peripheral blood lymphocytes stimulated by Candida, and on neutrophil functions, including leukotriene C(4) (LTC(4)) and superoxide (O(2)(-)) production by peripheral blood neutrophils. The results revealed, first, that, Sho-saiko-to, Hange-koboku-to, and Sho-seiryu-to did not have significant suppressive effects on IL-2 production and IL-2 receptor expression by Candia, though Saiboku-to caused significant suppression of these same parameters. Second, after 2 or 3 months oral administration to intractable asthmatics Saiboku-to (TJ-96) suppressed LTC(4) production by peripheral blood neutrophils in response to Candida and Ca-ionophore. Third, in vitro, Saiboku-to caused dose-dependent suppression of both LTC(4) and O(2)(-) production by peripheral blood neutrophils. Sho-saiko-to and Sho-seiryu-to also had suppressive effects on both LTC(4) and O(2)(-) production, with Sho-saiko-to causing the strongest suppression among these drugs. These results indicate that Saiboku-to might be useful in the treatment of intractable asthma due to its suppressive effect on type IV allergy caused by lymphocyte activation by Candida. Moreover, its inhibitory effect of LTC(4) and O(2)(-) production by neutrophils prevents prolonged broncho-constriction and irreversible changes in small airways. en-copyright= kn-copyright= en-aut-name=EdaRyosuke en-aut-sei=Eda en-aut-mei=Ryosuke kn-aut-name=江田良輔 kn-aut-sei=江田 kn-aut-mei=良輔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=難治性喘息 kn-keyword=難治性喘息 en-keyword=柴朴湯 kn-keyword=柴朴湯 en-keyword=漢方薬 kn-keyword=漢方薬 en-keyword=リンパ球 kn-keyword=リンパ球 en-keyword=好中球 kn-keyword=好中球 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=1 article-no= start-page=207 end-page=221 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199001 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=On Real Hypersurfaces of a Comples Space Form en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KiU-Hang en-aut-sei=Ki en-aut-mei=U-Hang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SuhYoung Jin en-aut-sei=Suh en-aut-mei=Young Jin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Kyungpook University affil-num=2 en-affil= kn-affil=Andong University END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue=1 article-no= start-page=233 end-page=240 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Real Hypersurfaces in Pn(C) with Constant Principal Curvatures en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KiU-Hang en-aut-sei=Ki en-aut-mei=U-Hang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakagiRyoichi en-aut-sei=Takagi en-aut-mei=Ryoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Kyungpook University affil-num=2 en-affil= kn-affil=Chiba University END start-ver=1.4 cd-journal=joma no-vol=48 cd-vols= no-issue=2 article-no= start-page=101 end-page=108 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Collagen Framework of the Volar Plate of Human Proximal Interphalangeal Joint en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The functional roles of the three-dimensional fibrillar ultrastructure of the proximal interphalangeal joint volar plates of human fingers were studied by light microscopy and scanning electron microscopy. The results revealed that the volar plate consists of three layers of fibers. The first layer forms an intracavity wall with two parts, the proximal "membranous portion", and the distal "meniscoid protrusion" that is separated from the middle phalangeal base by a "recess". The second layer contains the "check ligament", which lies parallel to the fibers of the tendon, anchors tightly into the middle phalangeal base, and protects the joint from hyperextension. The third layer connects to the fibers from the accessory ligament and ligamentous tendon sheath of the A3 pulley, perpendicularly crosses the fibers of the tendon, becomes the periosteum of the middle phalangeal base, and functions as a hanging support for the volar plate and as a gliding floor for the flexor tendon.

en-copyright= kn-copyright= en-aut-name=WatanabeHiroyoshi en-aut-sei=Watanabe en-aut-mei=Hiroyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HashizumeHiroyuki en-aut-sei=Hashizume en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InoueHajime en-aut-sei=Inoue en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OguraTakashi en-aut-sei=Ogura en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama Univeristy affil-num=4 en-affil= kn-affil=Okayama University en-keyword=human finger kn-keyword=human finger en-keyword=proximal interphalangeal joint kn-keyword=proximal interphalangeal joint en-keyword=volar plate kn-keyword=volar plate en-keyword=collagen framework kn-keyword=collagen framework END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=21 end-page=25 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199909 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=DEVELOPMENT OF "Luftain -Tg" AS A MICROISOLATION CAGE SYSTEM kn-title=ルフテンTgの開発 en-subtitle= kn-subtitle= en-abstract=Tgマウスの飼育に適し､かつ､飼育作業性の良いラックの開発を行った｡バスタブ型ケージを吊り式とし､天井／吊りレール／背面側塞ぎ板により上方3方を閉鎖しケージからの排気出口は上前面のケージ鍔上のみとした｡ケージ-の上後方からの直接給気とケージからの排気の流れは架台前面をエアカーテンで制御し､架台後方より排気することによりケージ内外の汚染の伝播を防止する機構になっており､コンピューター･シミュレーション及び気流可視化試験によりその効果が確認できた｡ kn-abstract=Developed "Luftain Tg" to include cage and luck for the breeding, nowadays an experiment increases as exchanging it digest gene set, and breeding, experiment of Transgenic mouse (following Tg mouse) increases. Doesn't exit the front of luck to outside as giving and doing a mind directly to cage inside, as a ceremony as hanging bathtub type cage-we controlled with a curtain and developed a system to defend from an expansion of cage inside and outside contamination. Again, for flowing of these air computer simulation even though were able to confirm it. en-copyright= kn-copyright= en-aut-name=SaitohM. en-aut-sei=Saitoh en-aut-mei=M. kn-aut-name=斎藤正信 kn-aut-sei=斎藤 kn-aut-mei=正信 aut-affil-num=1 ORCID= en-aut-name=OhshiroM. en-aut-sei=Ohshiro en-aut-mei=M. kn-aut-name=大城匡豊 kn-aut-sei=大城 kn-aut-mei=匡豊 aut-affil-num=2 ORCID= en-aut-name=ShiraganeK. en-aut-sei=Shiragane en-aut-mei=K. kn-aut-name=銀一之 kn-aut-sei=銀 kn-aut-mei=一之 aut-affil-num=3 ORCID= en-aut-name=HashizumeT. en-aut-sei=Hashizume en-aut-mei=T. kn-aut-name=橋詰俊雄 kn-aut-sei=橋詰 kn-aut-mei=俊雄 aut-affil-num=4 ORCID= en-aut-name=KurabayashiYuzuru en-aut-sei=Kurabayashi en-aut-mei=Yuzuru kn-aut-name=倉林譲 kn-aut-sei=倉林 kn-aut-mei=譲 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=大氣社 affil-num=2 en-affil= kn-affil=大氣社 affil-num=3 en-affil= kn-affil=白銀工業 affil-num=4 en-affil= kn-affil=白銀工業 affil-num=5 en-affil= kn-affil=岡山大学医学部附属動物実験施設 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=2-2 article-no= start-page=841 end-page=848 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Studies on Fat Embolism in the Organs at the Time of Wound Report 2 The Study on Fat Embolism in the Organs of the Animals at the Time of Wound kn-title=受傷時における臓器組織中遊離脂肪の意義 第U編 動物実験による受傷時におけの臓器組織中遊離脂肪の意義 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author made an experimental study with guinea-pigs and detected fat embolism in the lung in the same way as the report 1. The author obtained the following results. 1) It is confirmed that the occurrence of the fat embolism in the lung were the strongest in the case of injury on bones. There was proved the fat embolism in the lung also in the case of vertebral fracture. In the case of injury on soft part tissues by incised wounds, punctured wounds, cut wounds and contused wounds, there was proved an equal slight fat embolism in the lung. 2) There was slightly high degree of fat embolism in the lung in the case of injury on head rather than in the case of injury on breast, abdomen, and hands and feet. 3) There was confirmed the high degree of fat embolism in the lung in the case when the bodies have been left for about several minutes or several hours before death after wounded than those of sudden death, and showed a decline of fat embolism in the case when the bodies have been left for about 10 hours after wounded. 4) There was proved a remarkable fat embolism in the lung in the all cases of being run over and killed, and also proved a slight fat embolism in the case of death from burns. It is thought that these detections have a deep significance as a sign of vital reaction. 5) There was nothing in the cases of death from hanging, strangulation, strangulation by the hand and death of intoxication (carbon monoxide, potassium cyanide, arsenious acid and luminal). 6) The fat embolism that have been appeared in the lung showed no change by post-mortem operations such as being run over and killed, hanging and strangulation. 7) There was not proved the fat embolism in the lung by the decomposition of dead bodies, and the substance that would be dyed red by Sudan V. en-copyright= kn-copyright= en-aut-name=KusakaHironao en-aut-sei=Kusaka en-aut-mei=Hironao kn-aut-name=草加宏直 kn-aut-sei=草加 kn-aut-mei=宏直 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部法医学教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=7 article-no= start-page=2591 end-page=2598 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Anemia in Anchylosot. miasis by means of Bone Marrow Tissue Culture Part 3. Influences of an Addition of the Serum of Hook Worm Dogs on Bone Marrow Tissue Culture kn-title=骨髄組織培養による鉤虫症貧血の本態に関する研究 第3編 鉤虫犬血清添加が同種骨髄組織培養に及ぼす影響 附 全編の総括 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By adding a drop of the serum of dogs with ancylostomiasis in the medium of bone marrow tissue culture of normal dogs, the author has examined its influences on the growth rate, white blood cell function (wandering velocity, phagocytosis of carbon particles and vital staining of neutral red) in hanging drop culture and increasing rate of the red blood cell count and hemoglobin content in fluid culture. 1) As for the growth rate, it was slightly increased in the later atage of tissue culture. 2) Function of the neutrophils was not impedented on wandering velocity, phagocytosis of carbon particles and vital staining of neutral red, but rather slightly accerelated in the early stage of tissue culture. 3) According to the above mentioned results, the author has presumed that some stimulative substances for the bone marrow activity and neutrophils function are contained in the serum of hook wormdog. 4) Wandering velocity of the eosinophils was slightly increased, so that the author has resumed that it had occured from the stimulation of hook worm toxin possessing positive taxis for the eosinophils. 5) Increasing rate of the red blood cell count was not suffered from by adding the serum of hook worm dog on fluid culture, but that of hemoglobin content was slightly declined, which did not come from the restrain of hook worm toxin for the formation of hemoglobin, but from iron deficiency in the serum. en-copyright= kn-copyright= en-aut-name=YumotoMasaru en-aut-sei=Yumoto en-aut-mei=Masaru kn-aut-name=柚本賢 kn-aut-sei=柚本 kn-aut-mei=賢 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=7 article-no= start-page=2569 end-page=2579 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Anemia in Anchylostomiasis by means of Bone Marrow Tissue Culture Part 1. Bone Marrow Tissue Culture of Patients of Anchylostomiasis kn-title=骨髄組織培養による鉤虫症貧血の本態に関する研究 第1編 鉤虫症患者骨髄組織培養に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=By means of bone marrow tissue culture devised in author's laboratory, the author has investigated the hematopoietic activity and white blood cell function (wandering velocity, phagocytosis of carbon particles and vital staining) in the bone marrow of 16 cases of patients of anchylostomiasis, which were classified into 3 groups according to the level of anemia. 1) Relative growth rate in hanging-drop culture was hardly lowered in most cases, but in a group of severe anemia with a slight decrease of the white blood cell count in peripheral blood, it being slightly lowered. 2) Wandering velocity of the neutrophils was hardly decreased in most cases, but in a group of severe anemia with a slight decrease of the whitebolod cell count, it being slightly decreased. 3) Phagocytosis of carbon particles of the neutrophils was hardly declined in a group of slight anemia, but along with a development of anemia in peripheral blood, it being fairly declined, especially in a group of severe anemia with a slight decrease of the white blood cell count. 4) As for the vital staining of neutral red, it was little altered in most cases, but in cases of severe anemia with a slight decrease of the white blood cell count, the neutrophils were stained relatively in the early stage and high degree, and discolored comparatively earlier than those of the control one. 5) Wandering velocity of the eosiuophils in the bone marrow was markedly accelerated in most cases with eosinophilia in peripheral blood, sometimes being more than 2 times those of the control one. 6) Increasing rate of the red blood cell count and hemoglobin content in fluid culture were slightly decreased, especially in groups of moderate and severe anemia. 7) According to the above-mentioned results, the author has confirmed that the hematopoietic activity and blood cell function in the bone marrow of anchylostomiasis were scarecely deteriorated and the development of anemia should be regarded as the results of blood cell arrest in the sinusoid of the bone marrow and deficiency of an iron supply to the hematopoietic tissues due to the disturbance of iron mobilization, and moreover the development of hypoplastic anemia in anchylostomiasis should be considered as a secondary occurrence following a long durated severe anemia. en-copyright= kn-copyright= en-aut-name=YumotoMasaru en-aut-sei=Yumoto en-aut-mei=Masaru kn-aut-name=柚本賢 kn-aut-sei=柚本 kn-aut-mei=賢 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=1 article-no= start-page=49 end-page=61 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Bone Marrow of the Rabbit in Acute Bleeding Anemia way of Bone Marrow Tissue Culture Part 1. A Study on the Effect of Acute Bleeding Anemia on the Growth Area of Femur Bone-Marrow Culture of Rabbits kn-title=骨髄体外組織培養による急性瀉血家兎骨髄の態度に関する研究 第1編 急牲瀉血が家兎大腿骨々髄の増生面積に及ぼす影響に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author investigated from various angles behaviours of bone marrow of rabbits in acute bleeding anemia by bone marrow tissue culture. After acute bleeding of 20 cc./kg. of each rabbit, the recovery mechanism in the bone marrow has been compared with that of the normal rabbits by measuring the relative growth rate and the index of cellular density of the bone marrow in hanging drop culture at intervals of 1, 3, 5, 8, 12 and 24 hours as well as 2, 3, 5, 7, 10, 14 and 28 days after bleeding. It has been found that the growth area begins to decrease inmmediately after bleeding and shows the minimum value 5 hours after bleeding, but 12 hours afterwards it starts increasing and relative growth rate 24 hours after bleeding has increased 1.80 times that of the control; 2 days later 2.03 times; 3 days afterwards 2.29 times; 5 days later 2.37 times; and the maximum of accerelation of bone marrow mechanism has been found around 3-5 days after bleeding. The growth rate, which thus reaches the maximum 5 days after bleeding, begins to decrease thereafter and becomes nearly equal with that of the normal rabbits around 10-14 days afterwards. en-copyright= kn-copyright= en-aut-name=NumamotoTetsuro en-aut-sei=Numamoto en-aut-mei=Tetsuro kn-aut-name=沼本徹郎 kn-aut-sei=沼本 kn-aut-mei=徹郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=8-10 article-no= start-page=1609 end-page=1613 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of High Hydrostatic Pressure on Smooth Muscle Part T. On the longitudinal muscle of frog intestine kn-title=平滑筋に及ぼす高水圧の影響 其の一 蛙腸管縦走筋について en-subtitle= kn-subtitle= en-abstract= kn-abstract=When high hydrostatic pressure (50 to 500 kg/?) was applied to isolated longitudinal muscle strip (10 to 15 mm long, 2 to 3 mm wide) of frog intestine hanging in Ringer's solution, following changes of its length and rhythmical movement were observed. 1) Under high hydrostatic pressure up to 100 kg/? the rhythmical movement of the strip is accelerated in frequency and tonus effectively, depending on neurogenic nature, and at 300 to 500 kg/? it weakens or disappears. 2) When the pressure of about 300 to 500 kg/? is applied to the muscle strip, it lengthens quickly at first and then conversely shortens gradually after a certain limit of extension, and again the strip contracts rapidly but temporarily and then relaxes slowly. 3) These lengthening and subsequent shortening of the strip under high hydrostatic pressure of 300-500 kg/? seem to to of myogenic nature and not of neurogenic nature. en-copyright= kn-copyright= en-aut-name=MikiHukuziro en-aut-sei=Miki en-aut-mei=Hukuziro kn-aut-name=三木福治郎 kn-aut-sei=三木 kn-aut-mei=福治郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一生理学教室 END