Pathophysiology and Therapeutic Needs in Nonobstructive Hypertrophic Cardiomyopathy

Desai, Milind Y.; Maurizi, Niccolo; Biagini, Elena; Charron, Philippe; Fernandes, Fabio; González-López, Esther; van Haelst, Paul L.; Haugaa, Kristina Hermann; Kramer, Christopher M.; Meder, Benjamin; Michels, Michelle; Owens, Anjali; Yuasa, Shinsuke; Elliott, Perry

doi:10.1016/j.jchf.2025.102658

Permalink : https://ousar.lib.okayama-u.ac.jp/69401

フルテキストURL	fulltext.pdf 6.22 MB
著者	Desai, Milind Y. HCM Center, Department of Cardiovascular Medicine, Cleveland Clinic Maurizi, Niccolo Cardiomyopathy Unit, Careggi University Hospital Biagini, Elena Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna Charron, Philippe European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) Fernandes, Fabio InCor, Faculdade de Medicina da Universidade de São Paulo González-López, Esther Puerta de Hierro Majadahonda University Hospital, Health Research Institute of the Puerta de Hierro Majadahonda-Segovia de Arana University Hospital (IDIPHISA) van Haelst, Paul L. Cardiovascular Division, Department of Medicine, University of Virginia Health Haugaa, Kristina Hermann Cardiovascular Division, Department of Medicine, University of Virginia Health Kramer, Christopher M. Cardiovascular Division, Department of Medicine, University of Virginia Health Meder, Benjamin Department of Internal Medicine III, Institute for Cardiomyopathies, University of Heidelberg Michels, Michelle European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) Owens, Anjali Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Yuasa, Shinsuke Department of Cardiovascular Medicine, Academic Field, Dentistry and Pharmaceutical Sciences, Okayama University Elliott, Perry UCL Institute of Cardiovascular Science and St Bartholomew’s Hospital
抄録	Hypertrophic cardiomyopathy (HCM) affects individuals worldwide with an estimated prevalence of over 1 in 500 individuals. Nonobstructive HCM accounts for approximately 30% to 70% of cases, is extremely heterogeneous, and is associated with a notable degree of morbidity, including daily life limitations, ventricular tachyarrhythmias, progression to heart failure, and atrial fibrillation. No approved pharmaceutical therapies target the pathophysiology of nonobstructive HCM, although several clinical trials are underway. This narrative review provides a comprehensive overview of nonobstructive HCM, focusing on epidemiology, natural history, genetics, pathophysiology, clinical manifestations, diagnosis, burden of disease, and current treatments and ongoing clinical trials.
キーワード	heart failure hypertrophic cardiomyopathy nonobstructive
発行日	2025-11
出版物タイトル	JACC: Heart Failure
巻	13巻
号	11号
出版者	Elsevier BV
開始ページ	102658
ISSN	2213-1779
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 The Authors.
論文のバージョン	publisher
PubMed ID	40997544
DOI	10.1016/j.jchf.2025.102658
Web of Science KeyUT	001582063900001
関連URL	isVersionOf https://doi.org/10.1016/j.jchf.2025.102658
ライセンス	http://creativecommons.org/licenses/by-nc-nd/4.0/
助成情報	( Bristol Myers Squibb )