start-ver=1.4 cd-journal=joma no-vol=143 cd-vols= no-issue=4 article-no= start-page=393 end-page=404 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Awareness about the Establishment of Clinical Evidence among Community Pharmacists: A Large-scale Survey among Members of the Okayama Pharmaceutical Association kn-title=保険薬局薬剤師におけるエビデンス創出に対する意識：岡山県薬剤師会会員に対する大規模実態調査 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Community pharmacists in Japan participate in many important clinical cases involving drug therapies. This involvement should be researched and widely publicized to promote evidence-based medicine (EBM). However, the awareness level about the establishment of clinical evidence among community pharmacists remains unknown. Therefore, this large-scale questionnaire survey was conducted among members of the Okayama Pharmaceutical Association to clarify the awareness about the establishment of clinical evidence among community pharmacists to determine the major factors affecting their awareness. Questionnaires requiring open-ended responses were developed in Google Forms. Finally, 366 valid answers were obtained and statistically analyzed based on three aspects: academic conference presentation, research article publication, and research conduct. More than 50% of the participants agreed that they must engage in the establishment of clinical evidence. However, they were unwilling to engage in it by themselves. Additionally, the awareness about the establishment of clinical evidence among participants aged <40 years, who underwent a 6-year course, and with presentation experience was greater than that among participants aged ?40 years, who underwent a 4-year course and without presentation experience. Thus, age, course duration, and presentation experience are important factors influencing awareness about the establishment of clinical evidence. Further, >70% of the participants did not have enough time to engage in the establishment of clinical evidence, suggesting that reducing workload and ensuring adequate time are necessary for such engagements. Our novel findings may increase the establishment of clinical evidence by community pharmacists, improve community pharmacists’ social standing, and promote EBM in Japan. en-copyright= kn-copyright= en-aut-name=MatsumotoJun en-aut-sei=Matsumoto en-aut-mei=Jun kn-aut-name=松本准 kn-aut-sei=松本 kn-aut-mei=准 aut-affil-num=1 ORCID= en-aut-name=ItanoMadoka en-aut-sei=Itano en-aut-mei=Madoka kn-aut-name=板野円香 kn-aut-sei=板野 kn-aut-mei=円香 aut-affil-num=2 ORCID= en-aut-name=IwataNaohiro en-aut-sei=Iwata en-aut-mei=Naohiro kn-aut-name=岩田直大 kn-aut-sei=岩田 kn-aut-mei=直大 aut-affil-num=3 ORCID= en-aut-name=OroMasafumi en-aut-sei=Oro en-aut-mei=Masafumi kn-aut-name=大呂真史 kn-aut-sei=大呂 kn-aut-mei=真史 aut-affil-num=4 ORCID= en-aut-name=KitakazeChikako en-aut-sei=Kitakaze en-aut-mei=Chikako kn-aut-name=北風智佳子 kn-aut-sei=北風 kn-aut-mei=智佳子 aut-affil-num=5 ORCID= en-aut-name=HirotaAyuko en-aut-sei=Hirota en-aut-mei=Ayuko kn-aut-name=廣田あゆ子 kn-aut-sei=廣田 kn-aut-mei=あゆ子 aut-affil-num=6 ORCID= en-aut-name=MakinoKatsuhiko en-aut-sei=Makino en-aut-mei=Katsuhiko kn-aut-name=槇野克彦 kn-aut-sei=槇野 kn-aut-mei=克彦 aut-affil-num=7 ORCID= en-aut-name=TatenoTomoyuki en-aut-sei=Tateno en-aut-mei=Tomoyuki kn-aut-name=立野朋志 kn-aut-sei=立野 kn-aut-mei=朋志 aut-affil-num=8 ORCID= en-aut-name=TeraiRyohei en-aut-sei=Terai en-aut-mei=Ryohei kn-aut-name=寺井竜平 kn-aut-sei=寺井 kn-aut-mei=竜平 aut-affil-num=9 ORCID= en-aut-name=KenmotsuHideo en-aut-sei=Kenmotsu en-aut-mei=Hideo kn-aut-name=監物英男 kn-aut-sei=監物 kn-aut-mei=英男 aut-affil-num=10 ORCID= en-aut-name=DateMotohide en-aut-sei=Date en-aut-mei=Motohide kn-aut-name=伊達元英 kn-aut-sei=伊達 kn-aut-mei=元英 aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Personalized Medicine and Preventive Healthcare Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学学術研究院医歯薬学域 affil-num=2 en-affil=Okayama Pharmaceutical Association kn-affil=岡山県薬剤師会 affil-num=3 en-affil=Okayama Pharmaceutical Association kn-affil=岡山県薬剤師会 affil-num=4 en-affil=Okayama Pharmaceutical Association kn-affil=岡山県薬剤師会 affil-num=5 en-affil=Okayama Pharmaceutical Association kn-affil=岡山県薬剤師会 affil-num=6 en-affil=Okayama Pharmaceutical Association kn-affil=岡山県薬剤師会 affil-num=7 en-affil=Okayama Pharmaceutical Association kn-affil=岡山県薬剤師会 affil-num=8 en-affil=Okayama Pharmaceutical Association kn-affil=岡山県薬剤師会 affil-num=9 en-affil=Okayama Pharmaceutical Association kn-affil=岡山県薬剤師会 affil-num=10 en-affil=Okayama Pharmaceutical Association kn-affil=岡山県薬剤師会 affil-num=11 en-affil=Okayama Pharmaceutical Association kn-affil=岡山県薬剤師会 en-keyword=community pharmacists kn-keyword=community pharmacists en-keyword=questionnaire survey kn-keyword=questionnaire survey en-keyword=research kn-keyword=research en-keyword=academic conference presentation kn-keyword=academic conference presentation en-keyword=article publication kn-keyword=article publication END start-ver=1.4 cd-journal=joma no-vol=140 cd-vols= no-issue=5 article-no= start-page=657 end-page=661 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ゲノム医療におけるデータサイエンティストの役割と育成 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The development of specialized training programs for medical personnel, particularly nurses, clinical laboratory technicians, and pharmacists, is considered critical for the promotion of genomic medicine throughout Japan. Specifically, medical personnel skilled at analyzing and understanding high-throughput genomic data are in high demand. In this symposium, we will introduce the basic knowledge and skills necessary for processing genomic data. en-copyright= kn-copyright= en-aut-name=TomidaShuta en-aut-sei=Tomida en-aut-mei=Shuta kn-aut-name=冨田秀太 kn-aut-sei=冨田 kn-aut-mei=秀太 aut-affil-num=1 ORCID= en-aut-name=MoritaMizuki en-aut-sei=Morita en-aut-mei=Mizuki kn-aut-name=森田瑞樹 kn-aut-sei=森田 kn-aut-mei=瑞樹 aut-affil-num=2 ORCID= en-aut-name=YamashitaNoriyuki en-aut-sei=Yamashita en-aut-mei=Noriyuki kn-aut-name=山下範之 kn-aut-sei=山下 kn-aut-mei=範之 aut-affil-num=3 ORCID= en-aut-name=HirasawaAkira en-aut-sei=Hirasawa en-aut-mei=Akira kn-aut-name=平沢晃 kn-aut-sei=平沢 kn-aut-mei=晃 aut-affil-num=4 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name=豊岡伸一 kn-aut-sei=豊岡 kn-aut-mei=伸一 aut-affil-num=5 ORCID= affil-num=1 en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=2 en-affil=Department of Biorepository Research and Networking, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科クリニカルバイオバンクネットワーキング事業化研究講座 affil-num=3 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=岡山大学病院新医療研究開発センター affil-num=4 en-affil=Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科臨床遺伝子診療科 affil-num=5 en-affil=Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科呼吸器・乳腺内分泌外科 en-keyword=genomic medicine kn-keyword=genomic medicine en-keyword=tumor mutation burden kn-keyword=tumor mutation burden en-keyword=biomedical data science kn-keyword=biomedical data science en-keyword=bioinformatics kn-keyword=bioinformatics END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue=11 article-no= start-page=2103 end-page=2107 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20081101 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Royal jelly ameliorates insulin resistance in fructose-drinking rats en-subtitle= kn-subtitle= en-abstract= kn-abstract=Royal jelly (RJ) is known to contain excellent nutrition and a variety of biological activities. The present study was designed to investigate the effects of RJ on insulin resistance (hyperinsulinemia) in fructose-drinking rats (FDR; insulin resistance animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin and triglyceride, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), and systolic blood pressure, but not blood glucose levels, when compared with control rats. RJ (100, 300mg/kg, p.o.) treatment for 8 weeks significantly decreased the plasma levels of insulin and triglyceride, HOMA-R, without affecting blood glucose or total cholesterol levels and tended to lower systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, RJ treatment resulted in a significant reduction in sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase the calcitonin gene-related peptide (CGRP) nervemediated vasodilator response to PNS, compared with those in untreated FDR. However, RJ treatment did not significantly affect norepinephrine-induced vasoconstriction or CGRP-induced vasodilation. These results suggest that RJ could be an effective functional food to prevent insulin resistance associated with the development of hypertension. en-copyright= kn-copyright= en-aut-name=ZamamiYoshito en-aut-sei=Zamami en-aut-mei=Yoshito kn-aut-name=座間味義人 kn-aut-sei=座間味 kn-aut-mei=義人 aut-affil-num=1 ORCID= en-aut-name=TakatoriShingo en-aut-sei=Takatori en-aut-mei=Shingo kn-aut-name=高取真吾 kn-aut-sei=高取 kn-aut-mei=真吾 aut-affil-num=2 ORCID= en-aut-name=GodaMitsuhiro en-aut-sei=Goda en-aut-mei=Mitsuhiro kn-aut-name=合田光寛 kn-aut-sei=合田 kn-aut-mei=光寛 aut-affil-num=3 ORCID= en-aut-name=KoyamaToshihiro en-aut-sei=Koyama en-aut-mei=Toshihiro kn-aut-name=小山敏広 kn-aut-sei=小山 kn-aut-mei=敏広 aut-affil-num=4 ORCID= en-aut-name=IwataniYukiko en-aut-sei=Iwatani en-aut-mei=Yukiko kn-aut-name=岩谷有希子 kn-aut-sei=岩谷 kn-aut-mei=有希子 aut-affil-num=5 ORCID= en-aut-name=JinXin en-aut-sei=Jin en-aut-mei=Xin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=Takada-DoiShima en-aut-sei=Takada-Doi en-aut-mei=Shima kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KawasakiHiromu en-aut-sei=Kawasaki en-aut-mei=Hiromu kn-aut-name=川ｱ博己 kn-aut-sei=川ｱ kn-aut-mei=博己 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=2 en-affil= kn-affil=日本新薬創薬研究所 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=7 en-affil= kn-affil=山田養蜂場本社研究開発部 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 en-keyword=royal jelly kn-keyword=royal jelly en-keyword=fructose-drinking rat kn-keyword=fructose-drinking rat en-keyword=insulin resistance kn-keyword=insulin resistance en-keyword=periarterial nerve function kn-keyword=periarterial nerve function END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=12 article-no= start-page=2065 end-page=2073 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20071201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of propolis on insulin resistance in fructose-drinking rats kn-title=フルクトース負荷インスリン抵抗性モデル(ラット)におけるPropolisによるインスリン抵抗性改善作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Propolis, a honeybee product, contains a variety of biologically active substances. The present study was designed to investigate the effects of propolis on insulin resistance induced by fructose-drinking rats (FDR; type 2 diabetic animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), body weight, and systolic blood pressure but not blood glucose levels, when compared with control rats. Brazilian propolis extract (100 and 300mg/kg, p. o.) treatment for 8 weeks significantly decreased the plasma level of insulin, HOMA-R, and body weight, increased plasma triglyceride levels without affecting blood glucose and total cholesterol levels, and tended to decrease systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, propolis treatment resulted in a significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS; 8Hz) and tended to increase the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with those in untreated FDR. However, propolis treatment did not significantly affect norepinephrine-induced vasoconstriction and CGRP-induced vasodilation. These results suggest that propolis could be an effective functional food to prevent the development of insulin resistance. en-copyright= kn-copyright= en-aut-name=ZamamiYoshito en-aut-sei=Zamami en-aut-mei=Yoshito kn-aut-name=座間味義人 kn-aut-sei=座間味 kn-aut-mei=義人 aut-affil-num=1 ORCID= en-aut-name=TakatoriShingo en-aut-sei=Takatori en-aut-mei=Shingo kn-aut-name=高取真吾 kn-aut-sei=高取 kn-aut-mei=真吾 aut-affil-num=2 ORCID= en-aut-name=KoayamaToshihiro en-aut-sei=Koayama en-aut-mei=Toshihiro kn-aut-name=小山敏広 kn-aut-sei=小山 kn-aut-mei=敏広 aut-affil-num=3 ORCID= en-aut-name=GodaMitsuhiro en-aut-sei=Goda en-aut-mei=Mitsuhiro kn-aut-name=合田光寛 kn-aut-sei=合田 kn-aut-mei=光寛 aut-affil-num=4 ORCID= en-aut-name=IwataniYukiko en-aut-sei=Iwatani en-aut-mei=Yukiko kn-aut-name=岩谷有希子 kn-aut-sei=岩谷 kn-aut-mei=有希子 aut-affil-num=5 ORCID= en-aut-name=DoiShima en-aut-sei=Doi en-aut-mei=Shima kn-aut-name=土井志真 kn-aut-sei=土井 kn-aut-mei=志真 aut-affil-num=6 ORCID= en-aut-name=KawasakiHiromu en-aut-sei=Kawasaki en-aut-mei=Hiromu kn-aut-name=川ｱ博己 kn-aut-sei=川ｱ kn-aut-mei=博己 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=2 en-affil= kn-affil=日本新薬創薬研究所 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=6 en-affil= kn-affil=山田養蜂場本社研究開発部 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 en-keyword=propolis kn-keyword=propolis en-keyword=fructose-drinking rat kn-keyword=fructose-drinking rat en-keyword=insulin resistance kn-keyword=insulin resistance en-keyword=periarterial nerve function kn-keyword=periarterial nerve function END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=3 article-no= start-page=419 end-page=424 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080301 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of postprandial hyperglycemia and hyperinsulinemia on vascular responsiveness kn-title=食後高血糖が血管反応性に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recent clinical studies demonstrated that transient postprandial hyperglycemia and hyperinsulinemia may contribute to the development of hypertension. Therefore, we investigated influence of acute hyperglycemia and/or hyperinsulinemia induced by glucose or insulin infusion on neuronal and humoral control of vascular tone in rats. Euglycemic male Wistar rats were pithed under anesthesia and arterial blood pressure was measured. Changes in vascular responses to spinal cord stimulation (SCS) and intravenous bolus injections of noradrenaline, angiotensin II, calcitonin generelated peptide (CGRP), acetylcholine and sodium nitroprusside (SNP) were studied by infusing various concentration of glucose or insulin. Continuous glucose infusion, which increased both blood glucose and serum insulin levels, significantly augmented adrenergic nerve-mediated pressor responses to SCS without affecting injection of pressor responses to noradrenaline or angiotensin II. In pithed rats with artificially increased blood pressure and blockade of autonomic outflow, glucose infusion attenuated CGRPergic nerve-depressor responses to SCS without affecting depressor responses to injection of CGRP, acetylcholine or SNP. In pithed rats treated with octreotide, which increased blood glucose without increasing serum insulin levels, glucose infusion caused only significant augmentation of adrenergic nervemediated pressor responses. Combined infusion of insulin and glucose, which resulted in increased serum insulin levels with euglycemic, significantly augmented adrenergic nerve-mediated pressor responses and attenuated CGRPergic nerve-mediated depressor responses. The present results suggest that acute hyperglycemia and hyperinsulinemia increases adrenergic nerve-mediated vasoconstriction, which is partly associated with the blunted CGRPergic nerve function, and that plasma insulin concentration associated with hyperglycemia may be responsible for alteration of neuronal vascular regulation. en-copyright= kn-copyright= en-aut-name=ZamamiYoshito en-aut-sei=Zamami en-aut-mei=Yoshito kn-aut-name=座間味義人 kn-aut-sei=座間味 kn-aut-mei=義人 aut-affil-num=1 ORCID= en-aut-name=TakatoriShingo en-aut-sei=Takatori en-aut-mei=Shingo kn-aut-name=高取真吾 kn-aut-sei=高取 kn-aut-mei=真吾 aut-affil-num=2 ORCID= en-aut-name=IwataniYukiko en-aut-sei=Iwatani en-aut-mei=Yukiko kn-aut-name=岩谷有希子 kn-aut-sei=岩谷 kn-aut-mei=有希子 aut-affil-num=3 ORCID= en-aut-name=YamawakiKosuke en-aut-sei=Yamawaki en-aut-mei=Kosuke kn-aut-name=山脇康佑 kn-aut-sei=山脇 kn-aut-mei=康佑 aut-affil-num=4 ORCID= en-aut-name=MiyashitaSatoko en-aut-sei=Miyashita en-aut-mei=Satoko kn-aut-name=宮下智子 kn-aut-sei=宮下 kn-aut-mei=智子 aut-affil-num=5 ORCID= en-aut-name=YabumaeNana en-aut-sei=Yabumae en-aut-mei=Nana kn-aut-name=藪前奈々 kn-aut-sei=藪前 kn-aut-mei=奈々 aut-affil-num=6 ORCID= en-aut-name=TakayamaFusako en-aut-sei=Takayama en-aut-mei=Fusako kn-aut-name=高山房子 kn-aut-sei=高山 kn-aut-mei=房子 aut-affil-num=7 ORCID= en-aut-name=MioMitsunobu en-aut-sei=Mio en-aut-mei=Mitsunobu kn-aut-name=見尾光庸 kn-aut-sei=見尾 kn-aut-mei=光庸 aut-affil-num=8 ORCID= en-aut-name=KawasakiHiromu en-aut-sei=Kawasaki en-aut-mei=Hiromu kn-aut-name=川ｱ博己 kn-aut-sei=川ｱ kn-aut-mei=博己 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=2 en-affil= kn-affil=日本新薬(株)創薬研究所 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=8 en-affil= kn-affil=就実大学薬学部薬効解析学分野 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 en-keyword=hyperglycemia kn-keyword=hyperglycemia en-keyword=hyperinsulinemia kn-keyword=hyperinsulinemia en-keyword=Calcitonin gene-related peptide nerve kn-keyword=Calcitonin gene-related peptide nerve END start-ver=1.4 cd-journal=joma no-vol=130 cd-vols= no-issue=6 article-no= start-page=833 end-page=840 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ameliorative effect of propolis on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats kn-title=Propolis 長期投与による Otsuka Long-Evans Tokushima Fatty (OLETF) ラットの インスリン抵抗性改善作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Propolis is known to have abundant bioactive constituents and a variety of biological activities. To investigate the effect of Brazilian propolis on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a non-insulin-dependent type 2 diabetic model, were treated for 4 weeks with propolis (100 and 300 mg/kg, p.o.) or vehicle (control). Propolis treatment significantly decreased the plasma levels of insulin and insulin resistance index (Homeostasis Model Assessment-Insulin Resistance; HOM-IR), without affecting blood glucose levels and tended to lower systolic blood pressure compared with the control. In isolated and perfused mesenteric vascular beds of OLETF rats, propolis treatment resulted in significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS compared with in vehicle-treated OLETF rats. However, propolis treatment did not significantly affect the vasoconstrictor and vasodilator response to noradrenaline, CGRP, acetylcholine, and sodium nitroprusside. These results suggest that propolis could be an effective and functional food to prevent development of insulin resistance. en-copyright= kn-copyright= en-aut-name=ZamamiYoshito en-aut-sei=Zamami en-aut-mei=Yoshito kn-aut-name=座間味義人 kn-aut-sei=座間味 kn-aut-mei=義人 aut-affil-num=1 ORCID= en-aut-name=FujiwaraHiroki en-aut-sei=Fujiwara en-aut-mei=Hiroki kn-aut-name=藤原弘喜 kn-aut-sei=藤原 kn-aut-mei=弘喜 aut-affil-num=2 ORCID= en-aut-name=HosodaMiho en-aut-sei=Hosoda en-aut-mei=Miho kn-aut-name=細田美穂 kn-aut-sei=細田 kn-aut-mei=美穂 aut-affil-num=3 ORCID= en-aut-name=HinoHayato en-aut-sei=Hino en-aut-mei=Hayato kn-aut-name=日野隼人 kn-aut-sei=日野 kn-aut-mei=隼人 aut-affil-num=4 ORCID= en-aut-name=HiraiKazuhiro en-aut-sei=Hirai en-aut-mei=Kazuhiro kn-aut-name=平井和浩 kn-aut-sei=平井 kn-aut-mei=和浩 aut-affil-num=5 ORCID= en-aut-name=OkamotoKazuaki en-aut-sei=Okamoto en-aut-mei=Kazuaki kn-aut-name=岡本和明 kn-aut-sei=岡本 kn-aut-mei=和明 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=金? kn-aut-sei=金 kn-aut-mei=? aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高取真吾 kn-aut-sei=高取 kn-aut-mei=真吾 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高木志真 kn-aut-sei=高木 kn-aut-mei=志真 aut-affil-num=9 ORCID= en-aut-name=KawasakiHiromu en-aut-sei=Kawasaki en-aut-mei=Hiromu kn-aut-name=川ｱ博己 kn-aut-sei=川ｱ kn-aut-mei=博己 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=8 en-affil= kn-affil=日本新薬株式会社創薬研究所 affil-num=9 en-affil= kn-affil=山田養蜂場本社研究開発部 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 en-keyword=propolis kn-keyword=propolis en-keyword=insulin resistance kn-keyword=insulin resistance en-keyword=Otsuka Long-Evans Tokushima Fatty rat kn-keyword=Otsuka Long-Evans Tokushima Fatty rat en-keyword=periarterial nerve function kn-keyword=periarterial nerve function en-keyword=mesenteric vascular bed kn-keyword=mesenteric vascular bed END