| ID | 30954 |
| JaLCDOI | |
| フルテキストURL | |
| 著者 |
Nakanishi, Akira
Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Abe, Tadashi
Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Watanabe, Masami
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
publons
researchmap
Takei, Kohji
Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
publons
researchmap
Yamada, Hiroshi
Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
publons
researchmap
|
| 抄録 | Testicular Sertoli cells highly express dynamin 2 and amphiphysin 1. Here we demonstrate that dynamin 2 is implicated in phosphatidylserine (PS)-dependent phagocytosis in Sertoli cells. Immunofluorescence and dual-live imaging revealed that dynamin 2 and amphiphysin 1 accumulate simultaneously at ruffles. These proteins are specifically bound in vitro. Over-expression of dominant negative dynamin 2 (K44A) inhibits liposome-uptake and leads to the mis-localization of amphiphysin 1. Thus, the cooperative function of dynamin 2 and amphiphysin 1 in PS-dependent phagocytosis is strongly suggested. |
| キーワード | dynamin
amphiphysin
phagocytosis
testis
|
| Amo Type | Original Article
|
| 出版物タイトル |
Acta Medica Okayama
|
| 発行日 | 2008-12
|
| 巻 | 62巻
|
| 号 | 6号
|
| 出版者 | Okayama University Medical School
|
| 開始ページ | 385
|
| 終了ページ | 391
|
| ISSN | 0386-300X
|
| NCID | AA00508441
|
| 資料タイプ |
学術雑誌論文
|
| 言語 |
英語
|
| 論文のバージョン | publisher
|
| 査読 |
有り
|
| Web of Science KeyUT |
